## Mon Mar 17 22:43:20 2025 ## emapper-2.1.9 ## /home/zhangkaihang/.conda/envs/eggnog-mapper/bin/emapper.py -i /home/zhangkaihang/metadata_analysis/metawrap/paddysoil/4paddy/bin4gtdbtk/YYD2_bin.24.fa -m mmseqs --itype genome -o YYD2_bin.24 --output_dir /home/zhangkaihang/metadata_analysis/eggnog-mapper/paddysoil/4paddy/YYD2_bin.24 --cpu 8 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs YYD2_k127_104691_19 338966.Ppro_1664 3.609e-08 62.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,43BTG@68525|delta/epsilon subdivisions,2X74B@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA polymerase III, delta' holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C YYD2_k127_104691_9 880073.Calab_1952 8.555e-60 218.0 COG1774@1|root,COG1774@2|Bacteria,2NPEB@2323|unclassified Bacteria 2|Bacteria S PSP1 C-terminal conserved region yaaT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - - - - - - - - - - PSP1 YYD2_k127_104691_2 994573.T472_0209805 1.057e-154 510.0 COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,36E2T@31979|Clostridiaceae 186801|Clostridia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind YYD2_k127_104691_7 1304880.JAGB01000002_gene2401 4.548e-69 243.0 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia 186801|Clostridia L hydrolase, TatD family tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase YYD2_k127_104691_11 1397527.Q670_11265 1.903e-49 186.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XIZA@135619|Oceanospirillales 135619|Oceanospirillales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD YYD2_k127_104691_6 1540257.JQMW01000009_gene3300 5.339e-75 263.0 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,36EAK@31979|Clostridiaceae 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 YYD2_k127_104691_12 251229.Chro_2803 1.374e-47 175.0 COG1846@1|root,COG1846@2|Bacteria,1G6XI@1117|Cyanobacteria 1117|Cyanobacteria K MarR family transcriptional - - - ko:K15973 - - - - ko00000,ko03000 - - - MarR YYD2_k127_104691_8 1379698.RBG1_1C00001G1232 9.753e-69 237.0 COG1403@1|root,COG1403@2|Bacteria,2NPJD@2323|unclassified Bacteria 2|Bacteria L HNH endonuclease mcrA - - - - - - - - - - - HNH,HNH_4,HNH_5 YYD2_k127_104691_14 1237149.C900_00291 4.911e-43 161.0 2CHCP@1|root,32S5R@2|Bacteria,4NS9G@976|Bacteroidetes,47RF4@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 YYD2_k127_104691_0 1379698.RBG1_1C00001G1265 3.798e-200 635.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_104691_20 1288963.ADIS_1789 2.423e-07 63.0 2C5G3@1|root,2Z8TT@2|Bacteria,4P166@976|Bacteroidetes,47TW0@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_104691_4 251221.35212389 3.564e-84 284.0 COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria 1117|Cyanobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin YYD2_k127_104691_3 1379698.RBG1_1C00001G0378 1.39e-121 400.0 COG0150@1|root,COG0150@2|Bacteria,2NNUJ@2323|unclassified Bacteria 2|Bacteria F AIR synthase related protein, N-terminal domain purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1844,iECSF_1327.ECSF_2340 AIRS,AIRS_C YYD2_k127_104691_1 1321778.HMPREF1982_04157 1.999e-167 542.0 COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,267NF@186813|unclassified Clostridiales 186801|Clostridia G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N YYD2_k127_104691_5 1379698.RBG1_1C00001G0380 1.426e-76 276.0 COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria 2|Bacteria M Carbon-nitrogen hydrolase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase YYD2_k127_104691_17 1250005.PHEL85_1929 2.352e-19 104.0 COG3292@1|root,COG3292@2|Bacteria,4NDWE@976|Bacteroidetes,1HY9S@117743|Flavobacteriia,3VW0M@52959|Polaribacter 976|Bacteroidetes T periplasmic ligand-binding sensor domain - - - - - - - - - - - - Reg_prop YYD2_k127_104691_18 1379698.RBG1_1C00001G0382 2.209e-14 84.0 COG5653@1|root,COG5653@2|Bacteria 2|Bacteria M Protein involved in cellulose biosynthesis - - - - - - - - - - - - Acetyltransf_6 YYD2_k127_104691_15 1321778.HMPREF1982_03794 6.167e-28 126.0 COG0438@1|root,COG0438@2|Bacteria,1TSNT@1239|Firmicutes,248MH@186801|Clostridia 186801|Clostridia M Group 1 family - - - - - - - - - - - - Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 YYD2_k127_104691_13 1379698.RBG1_1C00001G0384 4.563e-44 176.0 COG0438@1|root,COG0438@2|Bacteria,2NPP9@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 YYD2_k127_104691_10 1379698.RBG1_1C00001G0386 4.707e-55 204.0 COG1216@1|root,COG1216@2|Bacteria,2NP9Z@2323|unclassified Bacteria 2|Bacteria GM Glycosyltransferase like family 2 wbbL - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2 YYD2_k127_104691_16 880073.Calab_0041 1.783e-23 112.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase YYD2_k127_104986_11 272559.BF9343_1478 5.47e-36 138.0 COG1004@1|root,COG1004@2|Bacteria,4NE00@976|Bacteroidetes,2FMZ9@200643|Bacteroidia,4AQ1P@815|Bacteroidaceae 976|Bacteroidetes C UDP binding domain - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N YYD2_k127_104986_7 1121413.JMKT01000015_gene262 1.691e-74 269.0 COG2244@1|root,COG2244@2|Bacteria,1QZC3@1224|Proteobacteria,42U79@68525|delta/epsilon subdivisions,2WQ6Z@28221|Deltaproteobacteria,2MFJW@213115|Desulfovibrionales 28221|Deltaproteobacteria S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt YYD2_k127_104986_8 871968.DESME_14465 4.347e-62 231.0 COG0438@1|root,COG0438@2|Bacteria,1V0G0@1239|Firmicutes,25BFP@186801|Clostridia 186801|Clostridia M Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 YYD2_k127_104986_14 118173.KB235914_gene3853 4.471e-24 112.0 COG2755@1|root,COG2755@2|Bacteria,1G31T@1117|Cyanobacteria,1H8QX@1150|Oscillatoriales 1117|Cyanobacteria E PFAM GDSL-like Lipase Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 YYD2_k127_104986_21 1158294.JOMI01000001_gene1652 8.39e-10 68.0 COG0110@1|root,COG0110@2|Bacteria,4NMYG@976|Bacteroidetes,2FPFF@200643|Bacteroidia 976|Bacteroidetes K Bacterial transferase hexapeptide repeat protein maa - 2.3.1.18,2.3.1.79 ko:K00633,ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac YYD2_k127_104986_12 1307759.JOMJ01000004_gene2503 2.544e-33 146.0 COG3307@1|root,COG3307@2|Bacteria,1QTKA@1224|Proteobacteria,42VD4@68525|delta/epsilon subdivisions,2WRBR@28221|Deltaproteobacteria,2MAIC@213115|Desulfovibrionales 28221|Deltaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C YYD2_k127_104986_3 1094980.Mpsy_2511 2.286e-108 361.0 COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,2NAQ2@224756|Methanomicrobia 224756|Methanomicrobia M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase YYD2_k127_104986_22 1519464.HY22_13055 1.238e-06 59.0 COG0265@1|root,COG0366@1|root,COG0265@2|Bacteria,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - Alpha-amylase YYD2_k127_104986_5 1121439.dsat_1282 9.29e-83 287.0 COG1215@1|root,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,439Z2@68525|delta/epsilon subdivisions,2X1YW@28221|Deltaproteobacteria,2M834@213115|Desulfovibrionales 28221|Deltaproteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 YYD2_k127_104986_13 1121459.AQXE01000003_gene1159 1.785e-27 122.0 COG1269@1|root,COG1269@2|Bacteria,1RF6T@1224|Proteobacteria,42RED@68525|delta/epsilon subdivisions,2WNV7@28221|Deltaproteobacteria,2MC3C@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM EpsI family protein - - - - - - - - - - - - DUF3485 YYD2_k127_104986_9 1121439.dsat_1302 2.298e-50 189.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,42R3N@68525|delta/epsilon subdivisions,2WMY8@28221|Deltaproteobacteria,2MAPG@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM eight transmembrane protein EpsH epsH - - - - - - - - - - - Exosortase_EpsH YYD2_k127_104986_4 880073.Calab_2000 1.727e-104 350.0 COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria 2|Bacteria GM NAD(P)H-binding wbpP - 5.1.3.2,5.1.3.7 ko:K01784,ko:K02473 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R00418,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd YYD2_k127_104986_17 1237149.C900_01254 1.006e-18 93.0 COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria,4NF1M@976|Bacteroidetes 976|Bacteroidetes O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8,Peptidase_S8_N YYD2_k127_104986_6 690850.Desaf_2134 5.623e-77 274.0 COG5653@1|root,COG5653@2|Bacteria,1Q8ZI@1224|Proteobacteria,431YG@68525|delta/epsilon subdivisions,2WWCM@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 YYD2_k127_104986_10 768671.ThimaDRAFT_1955 7.998e-48 184.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - DUF4915,Glycos_transf_2,TPR_1 YYD2_k127_104986_23 204669.Acid345_4648 1.066e-05 59.0 COG0745@1|root,COG0745@2|Bacteria,3Y8XM@57723|Acidobacteria 57723|Acidobacteria T Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,Response_reg YYD2_k127_104986_15 1089550.ATTH01000001_gene1005 2.946e-23 117.0 COG1404@1|root,COG3591@1|root,COG4932@1|root,COG1404@2|Bacteria,COG3591@2|Bacteria,COG4932@2|Bacteria,4NG2K@976|Bacteroidetes,1FJTD@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EO Trypsin-like serine protease - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - P_proprotein,Trypsin_2 YYD2_k127_104986_18 1033743.CAES01000085_gene2958 2.456e-18 101.0 COG1404@1|root,COG2730@1|root,COG1404@2|Bacteria,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process celA7 - 3.2.1.4,3.2.1.78 ko:K01179,ko:K01218 ko00051,ko00500,ko01100,ko02024,map00051,map00500,map01100,map02024 - R01332,R06200,R11307,R11308 RC00467 ko00000,ko00001,ko01000 - GH26,GH5,GH9 - CBM_3,CBM_35,F5_F8_type_C,Glyco_hydro_26,Glyco_hydro_44,Peptidase_S8,SLH,fn3 YYD2_k127_104986_19 1144275.COCOR_06342 7.377e-15 89.0 COG4932@1|root,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,438GF@68525|delta/epsilon subdivisions,2X3RA@28221|Deltaproteobacteria,2YWWZ@29|Myxococcales 28221|Deltaproteobacteria M Bacterial Ig-like domain (group 1) - - - - - - - - - - - - Big_1,LTD YYD2_k127_104986_2 682795.AciX8_4212 5.453e-117 386.0 COG0309@1|root,COG0309@2|Bacteria,3Y3UH@57723|Acidobacteria,2JK96@204432|Acidobacteriia 204432|Acidobacteriia O AIR synthase related protein, C-terminal domain - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C YYD2_k127_104986_0 517418.Ctha_1826 1.984e-170 541.0 COG0409@1|root,COG0409@2|Bacteria,1FD8B@1090|Chlorobi 1090|Chlorobi O hydrogenase expression formation protein HypD - - - ko:K04654 - - - - ko00000 - - - HypD YYD2_k127_104986_16 517418.Ctha_1825 4.438e-22 101.0 COG0298@1|root,COG0298@2|Bacteria,1FE7S@1090|Chlorobi 1090|Chlorobi O PFAM hydrogenase expression formation protein (HUPF HYPC) - - - ko:K04653 - - - - ko00000 - - - HupF_HypC YYD2_k127_104986_1 269799.Gmet_0119 1.092e-168 548.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,43S2B@69541|Desulfuromonadales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - iAF987.Gmet_0119 Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF YYD2_k127_1076709_4 1191523.MROS_1516 3.172e-79 269.0 COG0348@1|root,COG0348@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding ccoG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_18,Fer4_5,FixG_C YYD2_k127_1076709_6 929556.Solca_1393 1.771e-55 202.0 COG2010@1|root,COG2010@2|Bacteria,4NFMJ@976|Bacteroidetes,1IRZW@117747|Sphingobacteriia 976|Bacteroidetes C PFAM Cytochrome c, class I ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N YYD2_k127_1076709_0 391596.PBAL39_17989 0.0 1134.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,1IP6D@117747|Sphingobacteriia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO YYD2_k127_1076709_7 1191523.MROS_1512 8.461e-13 70.0 COG3197@1|root,COG3197@2|Bacteria 2|Bacteria P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS YYD2_k127_1076709_2 945713.IALB_0720 6.178e-238 760.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria 2|Bacteria P mercury ion transmembrane transporter activity fixI GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase YYD2_k127_1076709_1 1304874.JAFY01000001_gene2572 4.753e-289 899.0 COG1217@1|root,COG1217@2|Bacteria,3T9TF@508458|Synergistetes 508458|Synergistetes T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 YYD2_k127_1076709_3 1379698.RBG1_1C00001G0553 3.323e-132 428.0 COG1493@1|root,COG1493@2|Bacteria,2NP5B@2323|unclassified Bacteria 2|Bacteria T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N YYD2_k127_1076709_5 1379698.RBG1_1C00001G0706 5.315e-74 270.0 COG0760@1|root,COG0760@2|Bacteria,2NR9Y@2323|unclassified Bacteria 2|Bacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3,TPR_7 YYD2_k127_1085737_0 1379698.RBG1_1C00001G0581 2.827e-58 229.0 COG2911@1|root,COG2911@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - - - - - - - - - - - ASH,Cohesin,FlgD_ig,Peptidase_S74 YYD2_k127_1107448_2 221027.JO40_05860 4.555e-51 185.0 COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes 203691|Spirochaetes N Flagellar hook protein flgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C YYD2_k127_1107448_6 555088.DealDRAFT_2634 6.54e-17 86.0 2E35U@1|root,32Y5R@2|Bacteria,1VEH9@1239|Firmicutes,24R2S@186801|Clostridia,42K51@68298|Syntrophomonadaceae 186801|Clostridia N Pfam:DUF3766 flg - - - - - - - - - - - Flagellar_put YYD2_k127_1107448_5 573370.DMR_13740 8.969e-36 144.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,42U4T@68525|delta/epsilon subdivisions,2WQ5B@28221|Deltaproteobacteria,2MBHG@213115|Desulfovibrionales 28221|Deltaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig YYD2_k127_1107448_8 926692.AZYG01000007_gene1314 6.942e-06 59.0 COG3144@1|root,COG3144@2|Bacteria,1VAP1@1239|Firmicutes,24UIZ@186801|Clostridia 186801|Clostridia N PFAM flagellar hook-length control - - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook YYD2_k127_1107448_7 765869.BDW_12585 4.39e-07 60.0 COG3334@1|root,COG3334@2|Bacteria,1PT17@1224|Proteobacteria,437BU@68525|delta/epsilon subdivisions,2MTDP@213481|Bdellovibrionales,2X2H9@28221|Deltaproteobacteria 213481|Bdellovibrionales S PFAM MgtE intracellular - - - - - - - - - - - - - YYD2_k127_1107448_0 234267.Acid_4539 3.227e-297 929.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,3Y6VT@57723|Acidobacteria 57723|Acidobacteria C Malic enzyme, NAD binding domain - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic YYD2_k127_1107448_1 684719.HIMB114_00007680 8.857e-55 200.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,4BQAI@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid YYD2_k127_1107448_3 880073.Calab_1320 5.787e-45 186.0 COG0739@1|root,COG0739@2|Bacteria,2NR6F@2323|unclassified Bacteria 2|Bacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 YYD2_k127_1107448_4 439235.Dalk_3953 1.997e-44 181.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase nifM - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 YYD2_k127_1125812_1 880073.Calab_3144 2.474e-112 372.0 COG0171@1|root,COG0171@2|Bacteria 2|Bacteria H NAD+ synthase (glutamine-hydrolyzing) activity nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase YYD2_k127_1125812_10 498211.CJA_0020 2.445e-07 64.0 COG2931@1|root,COG4733@1|root,COG5306@1|root,COG2931@2|Bacteria,COG4733@2|Bacteria,COG5306@2|Bacteria,1PPUE@1224|Proteobacteria,1RQKW@1236|Gammaproteobacteria,1FHX1@10|Cellvibrio 1236|Gammaproteobacteria Q Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - CBM_6,HemolysinCabind,Laminin_G_3 YYD2_k127_1125812_9 1089550.ATTH01000001_gene1005 2.246e-09 71.0 COG1404@1|root,COG3591@1|root,COG4932@1|root,COG1404@2|Bacteria,COG3591@2|Bacteria,COG4932@2|Bacteria,4NG2K@976|Bacteroidetes,1FJTD@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EO Trypsin-like serine protease - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - P_proprotein,Trypsin_2 YYD2_k127_1125812_7 316067.Geob_2964 2.546e-45 178.0 COG0438@1|root,COG0438@2|Bacteria,1RJ6C@1224|Proteobacteria,42VPV@68525|delta/epsilon subdivisions,2WR9Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 YYD2_k127_1125812_5 1121439.dsat_1283 3.942e-55 209.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T1S@68525|delta/epsilon subdivisions,2WPVE@28221|Deltaproteobacteria,2MG45@213115|Desulfovibrionales 28221|Deltaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 YYD2_k127_1125812_8 396588.Tgr7_2371 1.491e-36 158.0 COG5653@1|root,COG5653@2|Bacteria,1N7WR@1224|Proteobacteria 1224|Proteobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 YYD2_k127_1125812_6 1123508.JH636440_gene2192 1.165e-49 191.0 COG0726@1|root,COG0726@2|Bacteria,2J0S7@203682|Planctomycetes 203682|Planctomycetes G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 YYD2_k127_1125812_4 1307759.JOMJ01000004_gene2493 2.055e-64 236.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T55@68525|delta/epsilon subdivisions,2WPW2@28221|Deltaproteobacteria,2MG3X@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 YYD2_k127_1125812_3 1123508.JH636443_gene4707 8.779e-84 292.0 COG0438@1|root,COG0438@2|Bacteria,2IZ69@203682|Planctomycetes 203682|Planctomycetes M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 YYD2_k127_1125812_2 941449.dsx2_1185 3.719e-107 362.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WMGG@28221|Deltaproteobacteria,2MATU@213115|Desulfovibrionales 28221|Deltaproteobacteria H coenzyme F390 - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - - YYD2_k127_1125812_0 667014.Thein_1210 2.58e-128 419.0 COG1004@1|root,COG1004@2|Bacteria,2GGQN@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N YYD2_k127_1144651_3 1121930.AQXG01000008_gene165 2.275e-88 302.0 COG0820@1|root,COG0820@2|Bacteria,4NFH5@976|Bacteroidetes,1IQMY@117747|Sphingobacteriia 976|Bacteroidetes J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM YYD2_k127_1144651_6 1121355.KB903379_gene745 6.674e-06 50.0 COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae 201174|Actinobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N YYD2_k127_1144651_4 745411.B3C1_17017 9.131e-75 267.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1J4GR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J SAM-dependent methyltransferases rlmI GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM YYD2_k127_1144651_2 880073.Calab_1608 3.002e-95 321.0 COG0437@1|root,COG0437@2|Bacteria,2NPJ0@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S dicluster domain - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_11,Fer4_4,Fer4_7 YYD2_k127_1144651_0 1191523.MROS_1571 5.09e-140 457.0 COG5557@1|root,COG5557@2|Bacteria 2|Bacteria C Polysulphide reductase, NrfD hybB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - iAPECO1_1312.APECO1_3427,iE2348C_1286.E2348C_3282,iECABU_c1320.ECABU_c34010,iECOK1_1307.ECOK1_3414,iECS88_1305.ECS88_3377,iUMN146_1321.UM146_01380,iUTI89_1310.UTI89_C3417 NrfD YYD2_k127_1144651_1 1379698.RBG1_1C00001G0775 9.471e-130 425.0 COG0484@1|root,COG0484@2|Bacteria,2NQUM@2323|unclassified Bacteria 2|Bacteria O Class III cytochrome C family - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - - - - - - - - - - Cytochrom_CIII,Cytochrom_c3_2 YYD2_k127_1144651_5 1123288.SOV_1c09840 1.046e-06 53.0 COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,4H4R5@909932|Negativicutes 909932|Negativicutes S domain protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 YYD2_k127_1154725_0 1379698.RBG1_1C00001G1819 6.684e-162 541.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1154725_1 1379698.RBG1_1C00001G1819 1.488e-50 194.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1207423_10 1379698.RBG1_1C00001G0125 8.25e-22 101.0 2EGJW@1|root,3110Q@2|Bacteria,2NS2A@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1207423_9 1379698.RBG1_1C00001G0126 8.829e-25 110.0 2C451@1|root,2ZRAU@2|Bacteria,2NS2X@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1207423_6 1216932.CM240_0088 4.267e-31 141.0 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,36DTA@31979|Clostridiaceae 186801|Clostridia E PFAM Extracellular ligand-binding receptor braC - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 YYD2_k127_1207423_1 1379698.RBG1_1C00001G0129 2.664e-56 201.0 COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria 2|Bacteria S Bifunctional nuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K03617,ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR YYD2_k127_1207423_3 1379698.RBG1_1C00001G0130 2.233e-40 154.0 COG0359@1|root,COG0359@2|Bacteria,2NPX4@2323|unclassified Bacteria 2|Bacteria J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N YYD2_k127_1207423_7 1379698.RBG1_1C00001G0131 1.916e-27 113.0 COG0238@1|root,COG0238@2|Bacteria,2NPTU@2323|unclassified Bacteria 2|Bacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 YYD2_k127_1207423_5 1379698.RBG1_1C00001G0132 2.589e-31 129.0 COG0629@1|root,COG0629@2|Bacteria,2NPP5@2323|unclassified Bacteria 2|Bacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB YYD2_k127_1207423_11 1379698.RBG1_1C00001G0133 1.138e-18 93.0 COG0360@1|root,COG0360@2|Bacteria,2NQ1Q@2323|unclassified Bacteria 2|Bacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 YYD2_k127_1207423_4 1313265.JNIE01000006_gene128 4.349e-40 158.0 COG0193@1|root,COG0193@2|Bacteria,2G42F@200783|Aquificae 200783|Aquificae J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro YYD2_k127_1207423_2 210007.SMU_1230c 1.307e-45 169.0 COG4333@1|root,COG4333@2|Bacteria,1VEFV@1239|Firmicutes,4HPB9@91061|Bacilli 91061|Bacilli S Protein conserved in bacteria - - - - - - - - - - - - DUF1643 YYD2_k127_1207423_8 926560.KE387023_gene2348 1.652e-26 118.0 COG0454@1|root,COG0456@2|Bacteria,1WMUE@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 YYD2_k127_1207423_0 880073.Calab_2857 1.101e-102 352.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - DUF2808,Peptidase_S46 YYD2_k127_1215115_12 557598.LHK_03146 1.614e-23 111.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,2KPZT@206351|Neisseriales 206351|Neisseriales LU DNA recombination-mediator protein A dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A YYD2_k127_1215115_16 388413.ALPR1_12685 1.352e-05 56.0 COG0457@1|root,COG0457@2|Bacteria,4PBMY@976|Bacteroidetes,47W2P@768503|Cytophagia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 YYD2_k127_1215115_11 1249480.B649_09540 1.837e-27 119.0 COG1858@1|root,COG1858@2|Bacteria 2|Bacteria C electron transfer activity - - - - - - - - - - - - CCP_MauG,Cytochrom_C,Cytochrom_D1,DHOR,Lactonase,RicinB_lectin_2 YYD2_k127_1215115_8 1009370.ALO_18817 4.78e-83 287.0 COG2103@1|root,COG2103@2|Bacteria,1TPSF@1239|Firmicutes,4H28B@909932|Negativicutes 909932|Negativicutes G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 YYD2_k127_1215115_15 439235.Dalk_0193 1.131e-11 66.0 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,42VWR@68525|delta/epsilon subdivisions,2WS4U@28221|Deltaproteobacteria,2MKU4@213118|Desulfobacterales 28221|Deltaproteobacteria P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 YYD2_k127_1215115_2 1120985.AUMI01000011_gene435 1.035e-135 441.0 COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4H26T@909932|Negativicutes 909932|Negativicutes E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 YYD2_k127_1215115_6 1123274.KB899430_gene1691 1.872e-92 312.0 COG0111@1|root,COG0111@2|Bacteria,2JA4I@203691|Spirochaetes 203691|Spirochaetes C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C YYD2_k127_1215115_3 880073.Calab_3201 6.74e-132 432.0 COG4198@1|root,COG4198@2|Bacteria,2NNV0@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1015) gdh - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - DUF1015 YYD2_k127_1215115_0 1379698.RBG1_1C00001G0614 1.193e-201 650.0 COG1505@1|root,COG1505@2|Bacteria,2NNUB@2323|unclassified Bacteria 2|Bacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N YYD2_k127_1215115_10 379066.GAU_3070 2.461e-31 128.0 COG5531@1|root,COG5531@2|Bacteria,1ZTZP@142182|Gemmatimonadetes 142182|Gemmatimonadetes B SWI complex, BAF60b domains - - - - - - - - - - - - SWIB YYD2_k127_1215115_9 880073.Calab_1657 1.434e-82 288.0 COG1408@1|root,COG1408@2|Bacteria,2NRFJ@2323|unclassified Bacteria 2|Bacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos YYD2_k127_1215115_1 1210884.HG799462_gene8232 3.86e-177 569.0 COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes 203682|Planctomycetes E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 YYD2_k127_1215115_5 1480694.DC28_08795 5.451e-102 341.0 COG1351@1|root,COG1351@2|Bacteria,2J68R@203691|Spirochaetes 203691|Spirochaetes F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 YYD2_k127_1215115_7 1379698.RBG1_1C00001G1194 3.876e-88 334.0 COG2911@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - 3.2.1.91 ko:K14194,ko:K19668 ko00500,ko01100,ko02020,ko05150,map00500,map01100,map02020,map05150 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CHU_C,DUF11,FlgD_ig,PKD,SdrD_B YYD2_k127_1215115_4 1379698.RBG1_1C00001G1819 3.492e-103 367.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1215115_13 404589.Anae109_4369 1.467e-21 97.0 COG1193@1|root,COG1193@2|Bacteria,1NCS6@1224|Proteobacteria,42VGJ@68525|delta/epsilon subdivisions,2WRA6@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Smr protein MutS2 - - - - - - - - - - - - Smr YYD2_k127_1215115_14 697284.ERIC2_c30240 1.571e-14 80.0 COG1164@1|root,COG1164@2|Bacteria,1TQ5W@1239|Firmicutes,4HAN9@91061|Bacilli,26S6W@186822|Paenibacillaceae 91061|Bacilli E oligoendopeptidase pepF2 - - - - - - - - - - - Peptidase_M3,Peptidase_M3_N YYD2_k127_1244238_2 1379698.RBG1_1C00001G1039 8.029e-65 231.0 COG0317@1|root,COG0317@2|Bacteria,2NNM0@2323|unclassified Bacteria 2|Bacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS YYD2_k127_1244238_3 1379698.RBG1_1C00001G1038 5.206e-59 218.0 COG0859@1|root,COG0859@2|Bacteria,2NPXQ@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 YYD2_k127_1244238_1 1379698.RBG1_1C00001G1037 5.887e-78 268.0 COG0463@1|root,COG0463@2|Bacteria,2NPA5@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferase family 2 kdtX - - ko:K12984 - - - - ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2 - Glycos_transf_2 YYD2_k127_1244238_5 1191523.MROS_2493 1.079e-27 126.0 COG0859@1|root,COG0859@2|Bacteria 2|Bacteria M ADP-heptose-lipopolysaccharide heptosyltransferase activity rfaF - - - - - - - - - - - Glyco_transf_9 YYD2_k127_1244238_4 768671.ThimaDRAFT_3128 3.757e-40 163.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RZRG@1236|Gammaproteobacteria,1WVXI@135613|Chromatiales 135613|Chromatiales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 YYD2_k127_1244238_0 945713.IALB_0362 3.977e-167 545.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter msbA - - ko:K02021,ko:K06147,ko:K06148,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran YYD2_k127_1267402_1 1379698.RBG1_1C00001G1751 1.177e-47 190.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2NP4I@2323|unclassified Bacteria 2|Bacteria U Metallo-beta-lactamase superfamily comEC - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B YYD2_k127_1267402_0 1379698.RBG1_1C00001G1752 4.213e-55 206.0 COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria 2|Bacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN YYD2_k127_1304127_22 526227.Mesil_2957 1.524e-29 124.0 COG0156@1|root,COG0156@2|Bacteria,1WIXA@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide - GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_1304127_4 929556.Solca_4459 5.199e-146 475.0 COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1IP7S@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_1304127_33 886293.Sinac_1596 1.106e-07 56.0 COG0236@1|root,COG0236@2|Bacteria,2J1MP@203682|Planctomycetes 203682|Planctomycetes IQ acyl carrier protein - - - - - - - - - - - - PP-binding YYD2_k127_1304127_1 237368.SCABRO_03415 3.674e-176 569.0 COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes 203682|Planctomycetes I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C YYD2_k127_1304127_31 1047013.AQSP01000059_gene2096 4.605e-10 66.0 COG0736@1|root,COG0736@2|Bacteria,2NPTD@2323|unclassified Bacteria 2|Bacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7,4.2.1.136 ko:K00997,ko:K17758 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS,Carb_kinase YYD2_k127_1304127_5 857293.CAAU_0042 3.405e-139 449.0 COG0451@1|root,COG0451@2|Bacteria,1TSUN@1239|Firmicutes,2485S@186801|Clostridia,36FJ8@31979|Clostridiaceae 186801|Clostridia M RmlD substrate binding domain - - - - - - - - - - - - Epimerase YYD2_k127_1304127_30 517418.Ctha_1876 1.955e-14 81.0 COG4577@1|root,COG4577@2|Bacteria,1FFCZ@1090|Chlorobi 1090|Chlorobi CQ BMC - - - - - - - - - - - - BMC YYD2_k127_1304127_11 525897.Dbac_2942 2.227e-67 256.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_1304127_35 1379281.AVAG01000075_gene1515 2.374e-05 57.0 COG3307@1|root,COG3307@2|Bacteria,1NGAP@1224|Proteobacteria,42XF9@68525|delta/epsilon subdivisions 1224|Proteobacteria M O-Antigen ligase - - - ko:K02847 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 - - Wzy_C YYD2_k127_1304127_12 340177.Cag_1137 3.573e-67 237.0 COG1194@1|root,COG1194@2|Bacteria,1FD5V@1090|Chlorobi 1090|Chlorobi L HhH-GPD family - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD YYD2_k127_1304127_36 1134474.O59_001444 0.0001551 51.0 COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,1FGY3@10|Cellvibrio 1236|Gammaproteobacteria KLT Sulfatase-modifying factor enzyme 1 ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - FGE-sulfatase,PEGA,Pkinase YYD2_k127_1304127_19 579138.Zymop_0446 1.004e-38 147.0 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,2VG5E@28211|Alphaproteobacteria,2K4TA@204457|Sphingomonadales 204457|Sphingomonadales H PFAM 6-pyruvoyl tetrahydropterin synthase and - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS YYD2_k127_1304127_16 1237149.C900_03709 7.216e-42 165.0 COG0602@1|root,COG0602@2|Bacteria,4NESC@976|Bacteroidetes,47MB1@768503|Cytophagia 976|Bacteroidetes H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14,Radical_SAM YYD2_k127_1304127_7 1125863.JAFN01000001_gene2317 3.66e-87 299.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_3075 QueC YYD2_k127_1304127_20 1026882.MAMP_02098 3.945e-38 147.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1RNXM@1236|Gammaproteobacteria,461HI@72273|Thiotrichales 72273|Thiotrichales S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF,QueF_N YYD2_k127_1304127_24 926560.KE387023_gene3760 5.808e-27 115.0 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - CHRD,Malectin YYD2_k127_1304127_10 316274.Haur_0493 1.873e-71 256.0 COG1902@1|root,COG1902@2|Bacteria,2G7MP@200795|Chloroflexi,3760K@32061|Chloroflexia 32061|Chloroflexia C PFAM NADH flavin oxidoreductase NADH oxidase - - 1.5.8.1,1.5.8.2 ko:K00317 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R01588,R02511 RC00185,RC00556,RC00557,RC00732 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 YYD2_k127_1304127_8 1123376.AUIU01000014_gene581 4.045e-85 290.0 COG2084@1|root,COG2084@2|Bacteria,3J0R5@40117|Nitrospirae 40117|Nitrospirae I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 YYD2_k127_1304127_0 1121920.AUAU01000012_gene2677 5.797e-182 586.0 COG0281@1|root,COG0281@2|Bacteria,3Y43V@57723|Acidobacteria 57723|Acidobacteria C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic YYD2_k127_1304127_3 42256.RradSPS_1129 3.564e-153 496.0 COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4CPEU@84995|Rubrobacteria 84995|Rubrobacteria G alpha beta alpha domain I - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV YYD2_k127_1304127_18 1379698.RBG1_1C00001G0561 1.883e-40 159.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02490 ko02020,ko02024,map02020,map02024 M00485 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c,HisKA_2,PAS_3,PAS_9,Response_reg,SpoIIE YYD2_k127_1304127_27 1280698.AUJS01000044_gene3380 1.091e-19 93.0 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,27VS6@189330|Dorea 186801|Clostridia L Uncharacterised protein family UPF0102 - - - ko:K07460 - - - - ko00000 - - - UPF0102 YYD2_k127_1304127_14 331113.SNE_A07610 1.761e-57 207.0 COG0164@1|root,COG0164@2|Bacteria,2JFYJ@204428|Chlamydiae 204428|Chlamydiae L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII YYD2_k127_1304127_26 888055.HMPREF9015_01781 2.749e-24 111.0 COG0742@1|root,COG0742@2|Bacteria,378KW@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 YYD2_k127_1304127_17 679201.HMPREF9334_01805 1.054e-41 156.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4H4PC@909932|Negativicutes 909932|Negativicutes J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 YYD2_k127_1304127_9 1379698.RBG1_1C00001G0950 3.809e-74 258.0 COG0336@1|root,COG0336@2|Bacteria,2NP5G@2323|unclassified Bacteria 2|Bacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 - - - tRNA_m1G_MT YYD2_k127_1304127_21 767817.Desgi_2744 8.539e-30 124.0 COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,2623V@186807|Peptococcaceae 186801|Clostridia J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM YYD2_k127_1304127_23 880073.Calab_2052 8.672e-28 114.0 COG1837@1|root,COG1837@2|Bacteria,2NPUP@2323|unclassified Bacteria 2|Bacteria S Belongs to the UPF0109 family ylqC - - ko:K06960 - - - - ko00000 - - - KH_4 YYD2_k127_1304127_25 1174504.AJTN02000173_gene3971 5.767e-26 111.0 COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,1ZGXP@1386|Bacillus 91061|Bacilli J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 YYD2_k127_1304127_2 880073.Calab_2050 4.968e-158 509.0 COG0541@1|root,COG0541@2|Bacteria,2NNT9@2323|unclassified Bacteria 2|Bacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB YYD2_k127_1304127_15 945713.IALB_2977 1.357e-56 207.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity dap2 - - - - - - - - - - - PD40,Peptidase_S9 YYD2_k127_1304127_34 1089545.KB913037_gene8972 5.592e-06 57.0 COG3794@1|root,COG3794@2|Bacteria,2H73G@201174|Actinobacteria,4E2Z7@85010|Pseudonocardiales 201174|Actinobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 YYD2_k127_1304127_28 1379698.RBG1_1C00001G0827 3.885e-16 88.0 COG3794@1|root,COG3794@2|Bacteria,2NRPQ@2323|unclassified Bacteria 2|Bacteria C blue (type 1) copper - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase_3,Cupredoxin_1 YYD2_k127_1304127_13 760568.Desku_0277 4.946e-59 209.0 arCOG10401@1|root,2ZA7Y@2|Bacteria,1V3TD@1239|Firmicutes,24I7A@186801|Clostridia,261TJ@186807|Peptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - YYD2_k127_1304127_6 1379698.RBG1_1C00001G0069 3.191e-123 430.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NRP6@2323|unclassified Bacteria 2|Bacteria O Subtilase family - - - ko:K13276 - - - - ko00000,ko01000,ko01002,ko03110 - - - CHU_C,FlgD_ig,PKD,Peptidase_S8 YYD2_k127_1312862_0 909663.KI867151_gene2966 0.0 1122.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1NT36@1224|Proteobacteria,42ZEC@68525|delta/epsilon subdivisions,2WU3Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 YYD2_k127_1312862_1 909663.KI867151_gene2965 4.94e-264 824.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MR61@213462|Syntrophobacterales 28221|Deltaproteobacteria C NADH ubiquinone oxidoreductase, NADH-binding - - 1.12.1.3,1.6.5.3 ko:K00124,ko:K00335,ko:K18331 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB YYD2_k127_1312862_24 909663.KI867151_gene2964 2.728e-57 203.0 COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,43DNM@68525|delta/epsilon subdivisions,2X6M5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K05586 ko00190,ko01100,map00190,map01100 - R11945 RC00061 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx YYD2_k127_1312862_37 909663.KI867151_gene2963 2.056e-08 62.0 COG2204@1|root,COG2204@2|Bacteria,1Q5EK@1224|Proteobacteria,433QZ@68525|delta/epsilon subdivisions,2WXYI@28221|Deltaproteobacteria 2|Bacteria T cheY-homologous receiver domain - - 2.1.1.80,3.1.1.61,3.1.3.3 ko:K03413,ko:K07315,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021 - - - HATPase_c,HDOD,HD_5,Response_reg YYD2_k127_1312862_21 42256.RradSPS_2733 7.173e-69 248.0 COG1600@1|root,COG1600@2|Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16,HEAT,HEAT_2 YYD2_k127_1312862_30 1292035.H476_3569 8.845e-36 151.0 COG3227@1|root,COG4886@1|root,COG3227@2|Bacteria,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia,25TYN@186804|Peptostreptococcaceae 186801|Clostridia E Leucine Rich repeats (2 copies) - - - - - - - - - - - - DUF3888,FIVAR,LRR_4 YYD2_k127_1312862_23 673860.AciM339_0561 7.452e-62 220.0 COG0036@1|root,arCOG05046@2157|Archaea,2XVS8@28890|Euryarchaeota,3F2JZ@33867|unclassified Euryarchaeota 28890|Euryarchaeota G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim YYD2_k127_1312862_11 1382306.JNIM01000001_gene766 5.062e-120 406.0 COG0166@1|root,COG0166@2|Bacteria,2G67J@200795|Chloroflexi 200795|Chloroflexi G Belongs to the GPI family pgi - 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,TAL_FSA YYD2_k127_1312862_2 309799.DICTH_1910 3.374e-208 665.0 COG0021@1|root,COG0021@2|Bacteria 2|Bacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N YYD2_k127_1312862_12 330214.NIDE2204 1.155e-115 381.0 COG1023@1|root,COG1023@2|Bacteria 2|Bacteria G D-gluconate metabolic process gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 YYD2_k127_1312862_4 1128421.JAGA01000002_gene1842 2.038e-168 543.0 COG0364@1|root,COG0364@2|Bacteria,2NNUR@2323|unclassified Bacteria 2|Bacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N YYD2_k127_1312862_29 1191523.MROS_0019 7.294e-42 156.0 COG0393@1|root,COG0393@2|Bacteria 2|Bacteria S Putative heavy-metal-binding ybjQ - - - - - - - - - - - YbjQ_1 YYD2_k127_1312862_28 1183438.GKIL_4241 1.205e-42 166.0 COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria 1117|Cyanobacteria G 6-phosphogluconolactonase pgl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso YYD2_k127_1312862_22 1183438.GKIL_2876 1.388e-64 232.0 COG0837@1|root,COG0837@2|Bacteria,1G1TJ@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase YYD2_k127_1312862_35 525904.Tter_1225 9.633e-17 89.0 COG1564@1|root,COG1564@2|Bacteria,2NPUG@2323|unclassified Bacteria 2|Bacteria H Thiamin pyrophosphokinase, vitamin B1 binding domain thiN - 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 - R00619 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TPK_B1_binding,TPK_catalytic YYD2_k127_1312862_14 1121957.ATVL01000014_gene1459 9.551e-107 376.0 COG5563@1|root,COG5563@2|Bacteria,4PHUI@976|Bacteroidetes,47VHU@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_1312862_38 1121935.AQXX01000066_gene2370 0.0002091 55.0 COG3488@1|root,COG3488@2|Bacteria 2|Bacteria C Di-haem oxidoreductase, putative peroxidase - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - DHOR,Glyco_hydro_16 YYD2_k127_1312862_16 1278073.MYSTI_07405 4.516e-88 297.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42ZGK@68525|delta/epsilon subdivisions,2WUTG@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_1312862_18 1123261.AXDW01000005_gene2667 4.204e-78 269.0 COG1682@1|root,COG1682@2|Bacteria,1QXTH@1224|Proteobacteria,1SPS5@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM ABC-2 type transporter - - - - - - - - - - - - ABC2_membrane YYD2_k127_1312862_34 641491.DND132_0528 1.964e-18 98.0 COG2197@1|root,COG2203@1|root,COG2197@2|Bacteria,COG2203@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,PAS_4,PAS_9 YYD2_k127_1312862_36 1267211.KI669560_gene478 1.901e-15 89.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,4NFC3@976|Bacteroidetes,1IW1P@117747|Sphingobacteriia 976|Bacteroidetes T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg YYD2_k127_1312862_33 684949.ATTJ01000002_gene106 6.871e-21 98.0 2ECKJ@1|root,33KDJ@2|Bacteria,1WMG2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus - - - - - - - - - - - - - - DinB_2 YYD2_k127_1312862_5 1191523.MROS_0749 2.947e-165 529.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM YYD2_k127_1312862_25 83219.PM02_10960 5.377e-57 224.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2TTUP@28211|Alphaproteobacteria,3ZVFM@60136|Sulfitobacter 28211|Alphaproteobacteria F Belongs to the 5'-nucleotidase family MA20_07595 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006213,GO:0006259,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007155,GO:0007159,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009164,GO:0009166,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019362,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0022610,GO:0031974,GO:0031981,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046135,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0072524,GO:0072527,GO:0072529,GO:0090304,GO:0098609,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5,3.6.1.45 ko:K01081,ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,LysM,Metallophos YYD2_k127_1312862_32 880073.Calab_0921 2.531e-23 117.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF4157,FctA,Peptidase_M43 YYD2_k127_1312862_27 429009.Adeg_1290 2.977e-43 160.0 COG4401@1|root,COG4401@2|Bacteria,1VAID@1239|Firmicutes,24N1H@186801|Clostridia,42H1D@68295|Thermoanaerobacterales 186801|Clostridia E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis aroH - 5.4.99.5 ko:K06208 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_1 YYD2_k127_1312862_6 706587.Desti_1323 3.455e-130 424.0 COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria,2MRCR@213462|Syntrophobacterales 28221|Deltaproteobacteria H PFAM DAHP synthetase I aroG-2 - 2.5.1.54,5.4.99.5 ko:K03856,ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 YYD2_k127_1312862_31 1121382.JQKG01000005_gene3253 4.85e-33 139.0 COG0287@1|root,COG0287@2|Bacteria,1WII2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDH YYD2_k127_1312862_9 1121920.AUAU01000007_gene487 1.753e-123 407.0 COG0436@1|root,COG0436@2|Bacteria,3Y2IZ@57723|Acidobacteria 57723|Acidobacteria E PFAM aminotransferase, class I - - - - - - - - - - - - Aminotran_1_2 YYD2_k127_1312862_19 358681.BBR47_51240 7.981e-76 263.0 COG0454@1|root,COG0456@2|Bacteria,1V40T@1239|Firmicutes,4HI2H@91061|Bacilli,26YNM@186822|Paenibacillaceae 91061|Bacilli K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 YYD2_k127_1312862_26 1191523.MROS_1636 4.908e-51 193.0 COG1295@1|root,COG1295@2|Bacteria 2|Bacteria S lipopolysaccharide transmembrane transporter activity rbn - - ko:K03303,ko:K07058 - - - - ko00000,ko02000 2.A.14 - - Virul_fac_BrkB YYD2_k127_1312862_39 1168289.AJKI01000007_gene130 0.0006108 48.0 2DNS2@1|root,32YVY@2|Bacteria,4PHI7@976|Bacteroidetes,2G1E5@200643|Bacteroidia,3XKYI@558415|Marinilabiliaceae 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_1312862_3 378806.STAUR_7818 6.42e-201 640.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2YUAB@29|Myxococcales 28221|Deltaproteobacteria S ABC transporter yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn YYD2_k127_1312862_15 204669.Acid345_4043 3.093e-89 313.0 COG1680@1|root,COG1680@2|Bacteria,3Y7SG@57723|Acidobacteria,2JMWV@204432|Acidobacteriia 204432|Acidobacteriia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase YYD2_k127_1312862_20 313606.M23134_01115 4.819e-71 252.0 COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,4NHRI@976|Bacteroidetes,47KP6@768503|Cytophagia 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 YYD2_k127_1312862_8 215803.DB30_5113 4.983e-124 416.0 COG0793@1|root,COG0793@2|Bacteria,1RGID@1224|Proteobacteria,4382G@68525|delta/epsilon subdivisions,2X3CI@28221|Deltaproteobacteria,2YVET@29|Myxococcales 28221|Deltaproteobacteria M tail specific protease - - - - - - - - - - - - Peptidase_S41 YYD2_k127_1312862_10 304371.MCP_1300 7.348e-123 400.0 COG1131@1|root,arCOG00194@2157|Archaea,2XVFB@28890|Euryarchaeota,2NARP@224756|Methanomicrobia 224756|Methanomicrobia E ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran YYD2_k127_1312862_13 1196323.ALKF01000149_gene1456 2.528e-107 366.0 COG1277@1|root,COG1277@2|Bacteria,1UP3Z@1239|Firmicutes,4IUZZ@91061|Bacilli,276YX@186822|Paenibacillaceae 2|Bacteria S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - - YYD2_k127_1312862_7 243231.GSU1164 3.623e-125 411.0 COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,42NT4@68525|delta/epsilon subdivisions,2WJFM@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_1312862_17 1379698.RBG1_1C00001G1667 2.145e-79 272.0 COG0577@1|root,COG0577@2|Bacteria,2NQPT@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_1321499_0 1267535.KB906767_gene5535 6.608e-59 223.0 COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria 57723|Acidobacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA,GAF_3,SpoIIE YYD2_k127_1336334_11 105559.Nwat_2888 4.193e-84 291.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales 135613|Chromatiales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD YYD2_k127_1336334_23 1379698.RBG1_1C00001G1847 1.332e-20 98.0 COG2825@1|root,COG2825@2|Bacteria,2NQ6C@2323|unclassified Bacteria 2|Bacteria M Outer membrane protein (OmpH-like) ompH - - ko:K06142 - - - - ko00000 - - - OmpH YYD2_k127_1336334_3 1379698.RBG1_1C00001G1846 1.834e-189 621.0 COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria 2|Bacteria M Surface antigen bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD2_k127_1336334_22 641491.DND132_1464 8.817e-22 98.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,42SGM@68525|delta/epsilon subdivisions,2WQ3I@28221|Deltaproteobacteria,2MCRH@213115|Desulfovibrionales 28221|Deltaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p YYD2_k127_1336334_1 1379698.RBG1_1C00001G1551 1.199e-289 904.0 COG0556@1|root,COG0556@2|Bacteria,2NNPM@2323|unclassified Bacteria 2|Bacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006950,GO:0008150,GO:0009314,GO:0009380,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0032991,GO:0035821,GO:0042802,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB YYD2_k127_1336334_26 745014.OMB55_00009050 0.0002332 50.0 COG1286@1|root,COG1286@2|Bacteria 2|Bacteria S toxin biosynthetic process cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V YYD2_k127_1336334_13 1379698.RBG1_1C00001G1834 2.334e-71 249.0 COG1028@1|root,COG1028@2|Bacteria,2NQVI@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.3.1.104 ko:K10780 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 YYD2_k127_1336334_18 555079.Toce_0610 5.625e-50 186.0 COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia,42FUN@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB YYD2_k127_1336334_8 1379698.RBG1_1C00001G0523 7.364e-101 344.0 COG0508@1|root,COG0508@2|Bacteria,2NNZ8@2323|unclassified Bacteria 2|Bacteria C e3 binding domain sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.168,2.3.1.61 ko:K00658,ko:K09699 ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00036 R02570,R02571,R02662,R03174,R04097,R08549,R10998 RC00004,RC02727,RC02833,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2766,iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding YYD2_k127_1336334_4 1379698.RBG1_1C00001G1873 3.991e-133 434.0 COG0379@1|root,COG0379@2|Bacteria,2NP47@2323|unclassified Bacteria 2|Bacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA YYD2_k127_1336334_7 1382315.JPOI01000001_gene1340 3.764e-108 362.0 COG0492@1|root,COG0492@2|Bacteria,1TRPN@1239|Firmicutes,4H9V7@91061|Bacilli,1WEJX@129337|Geobacillus 91061|Bacilli C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase yumC - 1.18.1.2,1.19.1.1 ko:K21567 - - - - ko00000,ko01000 - - iYO844.BSU32110 Pyr_redox_2 YYD2_k127_1336334_21 926569.ANT_29600 1.003e-42 162.0 COG0695@1|root,COG1225@1|root,COG0695@2|Bacteria,COG1225@2|Bacteria,2G6XD@200795|Chloroflexi 200795|Chloroflexi O Redoxin - - - - - - - - - - - - AhpC-TSA YYD2_k127_1336334_24 760568.Desku_0069 1.101e-10 64.0 COG1592@1|root,COG1592@2|Bacteria,1VB12@1239|Firmicutes,24JQ6@186801|Clostridia,262FT@186807|Peptococcaceae 186801|Clostridia C PFAM Rubredoxin-type Fe(Cys)4 protein - - - - - - - - - - - - - YYD2_k127_1336334_25 1121918.ARWE01000001_gene1253 0.0001163 51.0 COG1633@1|root,COG1633@2|Bacteria,1NEYR@1224|Proteobacteria,42VA3@68525|delta/epsilon subdivisions,2WS93@28221|Deltaproteobacteria,43SR0@69541|Desulfuromonadales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD2_k127_1336334_5 1379698.RBG1_1C00001G0761 4.437e-125 416.0 COG0008@1|root,COG0008@2|Bacteria,2NNMZ@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c YYD2_k127_1336334_2 1379698.RBG1_1C00001G0509 5.948e-246 780.0 COG1042@1|root,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria 2|Bacteria C synthetase (ADP forming), alpha - - 6.2.1.13 ko:K01905,ko:K09181,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig YYD2_k127_1336334_0 1379698.RBG1_1C00001G0186 0.0 1213.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N YYD2_k127_1336334_19 237368.SCABRO_03012 1.026e-47 181.0 2ANS9@1|root,31DS7@2|Bacteria,2IZX5@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD2_k127_1336334_16 247490.KSU1_B0648 7.72e-58 211.0 28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD2_k127_1336334_20 330214.NIDE2490 2.86e-44 169.0 29ZH8@1|root,30MGZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1336334_9 1379698.RBG1_1C00001G0119 6.868e-91 314.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_1336334_15 756272.Plabr_3384 6.58e-61 220.0 2ANS9@1|root,31DS7@2|Bacteria,2IZX5@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD2_k127_1336334_14 756272.Plabr_3383 3.073e-61 224.0 28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD2_k127_1336334_17 1379698.RBG1_1C00001G0118 2.117e-53 196.0 29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1336334_6 344747.PM8797T_23691 5.77e-110 369.0 28MEN@1|root,2ZASA@2|Bacteria,2IZ1H@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD2_k127_1336334_12 1379698.RBG1_1C00001G0116 7.175e-74 255.0 2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_1336334_10 1379698.RBG1_1C00001G0117 8.054e-90 306.0 28MYQ@1|root,2ZB5K@2|Bacteria,2NPC8@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_136361_2 153948.NAL212_0962 3.839e-12 81.0 COG2304@1|root,COG2304@2|Bacteria,1PE8B@1224|Proteobacteria,2WC99@28216|Betaproteobacteria,374H0@32003|Nitrosomonadales 28216|Betaproteobacteria S C-type lectin (CTL) or carbohydrate-recognition domain (CRD) - - - - - - - - - - - - VPEP YYD2_k127_136361_1 247490.KSU1_C0730 2.213e-12 81.0 COG2234@1|root,COG3291@1|root,COG3420@1|root,COG4409@1|root,COG5184@1|root,COG5276@1|root,COG2234@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4409@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity iap GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 ko:K01179,ko:K03929,ko:K09612,ko:K12287,ko:K19701,ko:K19702 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko02044 - CE10,GH5,GH9 - Beta_helix,Peptidase_M28 YYD2_k127_136361_0 84531.JMTZ01000001_gene2271 1.711e-15 92.0 COG3291@1|root,COG3420@1|root,COG4935@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4935@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - 3.4.11.10,3.4.21.50,3.4.24.25,3.4.24.3 ko:K01337,ko:K01387,ko:K05994,ko:K08604,ko:K14645,ko:K20276 ko02024,ko05110,ko05111,map02024,map05110,map05111 - - - ko00000,ko00001,ko01000,ko01002,ko02042,ko03110 - - - Inhibitor_I9,LVIVD,PKD,P_proprotein,Peptidase_M14,Peptidase_S8 YYD2_k127_1366157_3 1379698.RBG1_1C00001G0733 6.026e-87 317.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1366157_8 880073.Calab_3408 5.497e-17 88.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - Cytochrome_C554,DUF11,SLH YYD2_k127_1366157_4 880073.Calab_0603 1.482e-72 262.0 COG0438@1|root,COG0438@2|Bacteria,2NQ20@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferases group 1 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 YYD2_k127_1366157_0 880073.Calab_1670 3.548e-157 509.0 COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine csdA - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 YYD2_k127_1366157_1 1453500.AT05_06665 1.294e-132 431.0 COG0381@1|root,COG0381@2|Bacteria,4NGBD@976|Bacteroidetes,1HXDA@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - 5.1.3.23 ko:K13019 ko00520,map00520 - R09600 RC00290 ko00000,ko00001,ko01000,ko01005 - - - Epimerase_2 YYD2_k127_1366157_6 709991.Odosp_3064 2.131e-32 134.0 COG1704@1|root,COG1704@2|Bacteria,4NMD3@976|Bacteroidetes,2FNPV@200643|Bacteroidia,22XSI@171551|Porphyromonadaceae 976|Bacteroidetes S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA YYD2_k127_1366157_5 700598.Niako_5140 5.48e-37 151.0 COG1512@1|root,COG1512@2|Bacteria,4NF4P@976|Bacteroidetes,1IQMF@117747|Sphingobacteriia 976|Bacteroidetes S COG1512 Beta-propeller domains of methanol dehydrogenase type - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase YYD2_k127_1366157_7 1346791.M529_07510 4.069e-21 105.0 COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2U5XG@28211|Alphaproteobacteria,2K470@204457|Sphingomonadales 204457|Sphingomonadales S membrane - - - ko:K08988 - - - - ko00000 - - - TPM_phosphatase YYD2_k127_1366157_2 290397.Adeh_0511 9.955e-102 342.0 COG0475@1|root,COG0475@2|Bacteria,1RA3J@1224|Proteobacteria,43EWJ@68525|delta/epsilon subdivisions,2WTW1@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger YYD2_k127_1371094_13 56110.Oscil6304_4880 4.317e-09 61.0 COG5185@1|root,COG5185@2|Bacteria,1GQBC@1117|Cyanobacteria,1HGAS@1150|Oscillatoriales 1117|Cyanobacteria D Phage-related minor tail protein - - - - - - - - - - - - - YYD2_k127_1371094_3 1379698.RBG1_1C00001G1319 1.345e-74 256.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 YYD2_k127_1371094_1 1379698.RBG1_1C00001G0356 3.374e-132 459.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,2NS3S@2323|unclassified Bacteria 2|Bacteria EG Protein of unknown function (DUF2723) - - - ko:K16928 - M00582 - - ko00000,ko00002,ko02000 3.A.1.33 - - DUF2723,QueT YYD2_k127_1371094_10 518766.Rmar_0030 1.692e-21 99.0 COG0781@1|root,COG0781@2|Bacteria,4NDVR@976|Bacteroidetes,1FJJ7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB YYD2_k127_1371094_4 1123325.JHUV01000002_gene125 1.703e-62 218.0 COG0054@1|root,COG0054@2|Bacteria,2G3YV@200783|Aquificae 200783|Aquificae H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase YYD2_k127_1371094_0 945713.IALB_2105 1.816e-164 527.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria 2|Bacteria H GTP cyclohydrolase II activity ribBA - 3.5.4.25,4.1.99.12 ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 YYD2_k127_1371094_8 1123371.ATXH01000004_gene1796 5.995e-51 188.0 COG0307@1|root,COG0307@2|Bacteria,2GGV7@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H Lumazine binding domain - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding YYD2_k127_1371094_2 574087.Acear_1431 1.77e-95 324.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,3WAED@53433|Halanaerobiales 186801|Clostridia H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 YYD2_k127_1371094_12 443143.GM18_3684 2.817e-15 80.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WMEF@28221|Deltaproteobacteria,43TIX@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_1371094_9 1379698.RBG1_1C00001G1425 1.295e-48 183.0 COG1039@1|root,COG1039@2|Bacteria,2NPUQ@2323|unclassified Bacteria 2|Bacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03471 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DUF3378,RNase_HII YYD2_k127_1371094_6 1379698.RBG1_1C00001G1427 3.624e-60 214.0 COG0231@1|root,COG0231@2|Bacteria,2NPID@2323|unclassified Bacteria 2|Bacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C YYD2_k127_1371094_5 1379698.RBG1_1C00001G1199 1.226e-60 233.0 COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria 2|Bacteria T Signal transduction histidine kinase, nitrogen specific, NtrB - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_9 YYD2_k127_1371094_7 56780.SYN_00575 2.335e-59 214.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2MQEJ@213462|Syntrophobacterales 28221|Deltaproteobacteria M Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 YYD2_k127_1371094_11 796942.HMPREF9623_00728 1.013e-17 87.0 COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia 186801|Clostridia J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA YYD2_k127_1437051_0 1379698.RBG1_1C00001G0540 1.485e-08 70.0 COG1520@1|root,COG1520@2|Bacteria,2NQ51@2323|unclassified Bacteria 2|Bacteria O NHL repeat containing protein - - - - - - - - - - - - PQQ_2,SBBP YYD2_k127_1468706_1 1279009.ADICEAN_02760 7.464e-26 112.0 COG2318@1|root,COG2318@2|Bacteria,4NRAP@976|Bacteroidetes,47NZT@768503|Cytophagia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 YYD2_k127_1468706_0 1173264.KI913949_gene709 3.281e-49 183.0 COG0235@1|root,COG0235@2|Bacteria,1G2EA@1117|Cyanobacteria,1H8JN@1150|Oscillatoriales 1117|Cyanobacteria E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) mtnB - 4.2.1.109 ko:K08964 ko00270,ko01100,map00270,map01100 M00034 R07392 RC01939 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II YYD2_k127_1468706_2 530564.Psta_3140 0.0008996 43.0 COG1791@1|root,COG1791@2|Bacteria,2J2NB@203682|Planctomycetes 203682|Planctomycetes H Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway mtnD - 1.13.11.53,1.13.11.54 ko:K08967 ko00270,ko01100,map00270,map01100 M00034 R07363,R07364 RC01866,RC02018,RC02118 ko00000,ko00001,ko00002,ko01000 - - - ARD YYD2_k127_1483487_1 1379698.RBG1_1C00001G0287 2.767e-149 490.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 YYD2_k127_1483487_5 1379698.RBG1_1C00001G0286 6.504e-51 207.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria 1379698.RBG1_1C00001G0286|- KLT protein kinase activity - - - - - - - - - - - - - YYD2_k127_1483487_2 1379698.RBG1_1C00001G0175 4.762e-131 446.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,2NRE7@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02022,ko:K16922,ko:K20345 ko02024,map02024 - - - ko00000,ko00001,ko01002,ko02000 3.A.1.112,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,PqqD YYD2_k127_1483487_3 1379698.RBG1_1C00001G1223 8.759e-122 401.0 COG0665@1|root,COG0665@2|Bacteria,2NP0X@2323|unclassified Bacteria 2|Bacteria E FAD dependent oxidoreductase - - 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO YYD2_k127_1483487_7 397948.Cmaq_1150 4.802e-07 60.0 COG1073@1|root,arCOG01649@2157|Archaea 2157|Archaea E COG1073 Hydrolases of the alpha beta superfamily - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 YYD2_k127_1483487_0 1379698.RBG1_1C00001G1211 1.772e-188 599.0 COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria 2|Bacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iSB619.SA_RS05225 GATase_6,GATase_7,Pribosyltran YYD2_k127_1483487_4 398767.Glov_3125 1.42e-118 397.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M YYD2_k127_1501101_12 1282361.ABAC402_09290 2.629e-05 55.0 29XIV@1|root,30J9U@2|Bacteria,1NN8G@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - YYD2_k127_1501101_14 880073.Calab_0316 0.0006641 50.0 2DSWV@1|root,33HR1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1501101_3 1191523.MROS_0297 5.374e-59 216.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria 2|Bacteria M undecaprenyl-phosphate glucose phosphotransferase activity wcaJ GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046402,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.187,2.7.8.40 ko:K05946,ko:K21303 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - GT26 - Bac_transf,CoA_binding_3 YYD2_k127_1501101_11 1392490.JHZX01000001_gene163 4.204e-12 77.0 COG2067@1|root,COG2067@2|Bacteria,4NHNC@976|Bacteroidetes,1HZFD@117743|Flavobacteriia 976|Bacteroidetes I penicillin-binding protein porQ - - - - - - - - - - - PorP_SprF YYD2_k127_1501101_2 1379698.RBG1_1C00001G0405 3.456e-62 224.0 COG4784@1|root,COG4784@2|Bacteria,2NS4E@2323|unclassified Bacteria 2|Bacteria S Peptidase family M48 MA20_40030 - - - - - - - - - - - LysM,Peptidase_M48 YYD2_k127_1501101_0 1123376.AUIU01000014_gene636 1.141e-167 554.0 COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae 40117|Nitrospirae G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glyco_hydro_57 YYD2_k127_1501101_10 945713.IALB_0805 9.534e-15 83.0 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization CP_0079 - - ko:K15368 - - - - ko00000 - - - TPR_16,TPR_21,TPR_6 YYD2_k127_1501101_7 1121396.KB893001_gene3951 3.676e-20 104.0 COG2067@1|root,COG2067@2|Bacteria,1NHG3@1224|Proteobacteria 1224|Proteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X YYD2_k127_1501101_4 1379698.RBG1_1C00001G1172 7.833e-53 191.0 COG0503@1|root,COG0503@2|Bacteria,2NPGX@2323|unclassified Bacteria 2|Bacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - PRTase_2,Pribosyltran,TRSP YYD2_k127_1501101_8 518766.Rmar_1812 2.394e-19 91.0 COG1254@1|root,COG1254@2|Bacteria,4NVB4@976|Bacteroidetes,1FJMR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Acylphosphatase acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase YYD2_k127_1501101_6 1379698.RBG1_1C00001G1174 3.206e-41 157.0 COG1611@1|root,COG1611@2|Bacteria,2NPJB@2323|unclassified Bacteria 2|Bacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DNA_processg_A,Lysine_decarbox YYD2_k127_1501101_1 648996.Theam_1712 6.005e-63 228.0 COG0496@1|root,COG0496@2|Bacteria,2G3WU@200783|Aquificae 200783|Aquificae S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE YYD2_k127_1501101_5 1379698.RBG1_1C00001G1176 6.78e-49 184.0 COG1216@1|root,COG1216@2|Bacteria,2NS4X@2323|unclassified Bacteria 2|Bacteria S Glycosyl transferase family 2 XK27_08075 - - - - - - - - - - - DUF2062,Glycos_transf_2,GtrA,Lip_A_acyltrans YYD2_k127_1501101_13 59538.XP_005979423.1 0.0004857 43.0 COG0277@1|root,KOG1231@2759|Eukaryota,38FXH@33154|Opisthokonta,3BEEV@33208|Metazoa,3CRTP@33213|Bilateria,4801S@7711|Chordata,492UT@7742|Vertebrata,3JDRF@40674|Mammalia,4J43Y@91561|Cetartiodactyla 33208|Metazoa C dehydrogenase - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4,Fer4_8 YYD2_k127_1534674_14 1379698.RBG1_1C00001G1420 6.268e-35 153.0 COG0457@1|root,COG0457@2|Bacteria 1379698.RBG1_1C00001G1420|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - YYD2_k127_1534674_18 398720.MED217_10482 4.47e-07 62.0 28JUF@1|root,2Z9JH@2|Bacteria,4NHS3@976|Bacteroidetes,1HYHH@117743|Flavobacteriia,2XJ92@283735|Leeuwenhoekiella 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_1534674_13 1379698.RBG1_1C00001G0287 1.656e-39 168.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 YYD2_k127_1534674_6 1379698.RBG1_1C00001G1238 9.66e-95 335.0 COG5000@1|root,COG5000@2|Bacteria,2NQEP@2323|unclassified Bacteria 2|Bacteria T COGs COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,dCache_1 YYD2_k127_1534674_3 936053.I1C0K4 2.757e-134 441.0 COG0372@1|root,KOG2617@2759|Eukaryota,38CK5@33154|Opisthokonta,3NU5Z@4751|Fungi,1GSDT@112252|Fungi incertae sedis 4751|Fungi C Citrate synthase, C-terminal domain CIT1 GO:0003674,GO:0003824,GO:0004108,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005975,GO:0006081,GO:0006082,GO:0006084,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006139,GO:0006163,GO:0006195,GO:0006520,GO:0006536,GO:0006537,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009060,GO:0009064,GO:0009084,GO:0009109,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0015980,GO:0016053,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0032787,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0036440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046356,GO:0046394,GO:0046434,GO:0046483,GO:0046487,GO:0046700,GO:0046912,GO:0051186,GO:0051187,GO:0055086,GO:0055114,GO:0070013,GO:0071704,GO:0072350,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt YYD2_k127_1534674_7 338963.Pcar_2765 2.097e-90 314.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,43SAR@69541|Desulfuromonadales 28221|Deltaproteobacteria C FAD linked oxidases, C-terminal domain larD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - iAF987.Gmet_3245 FAD-oxidase_C,FAD_binding_4 YYD2_k127_1534674_16 880073.Calab_0928 5.542e-24 105.0 COG2331@1|root,COG2331@2|Bacteria,2NQ36@2323|unclassified Bacteria 2|Bacteria S Putative regulatory protein fmdB - - - - - - - - - - - Zn-ribbon_8 YYD2_k127_1534674_1 945713.IALB_1601 3.953e-200 638.0 COG0659@1|root,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - iSbBS512_1146.SbBS512_E1370 STAS,Sulfate_transp YYD2_k127_1534674_15 1121406.JAEX01000005_gene2987 7.509e-34 135.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2WRJJ@28221|Deltaproteobacteria,2MCMH@213115|Desulfovibrionales 28221|Deltaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB YYD2_k127_1534674_11 580340.Tlie_1484 7.997e-46 168.0 COG1993@1|root,COG1993@2|Bacteria,3TCBR@508458|Synergistetes 508458|Synergistetes S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 YYD2_k127_1534674_0 945713.IALB_1079 6.689e-245 767.0 COG1866@1|root,COG1866@2|Bacteria 2|Bacteria H phosphoenolpyruvate carboxykinase (ATP) activity pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP YYD2_k127_1534674_2 945713.IALB_1080 1.994e-155 500.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_1534674_5 373903.Hore_10200 5.167e-103 345.0 COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,3WABQ@53433|Halanaerobiales 186801|Clostridia C PFAM Phosphate acetyl butaryl transferase pta GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB YYD2_k127_1534674_4 880073.Calab_1379 9.071e-134 435.0 COG1186@1|root,COG1186@2|Bacteria,2NNU3@2323|unclassified Bacteria 2|Bacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 YYD2_k127_1534674_8 1379698.RBG1_1C00001G1027 1.906e-59 213.0 COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria 2|Bacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B YYD2_k127_1534674_12 635013.TherJR_1575 6.245e-43 168.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,26325@186807|Peptococcaceae 186801|Clostridia E histidinol phosphate phosphatase - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP YYD2_k127_1534674_9 351160.RCIX1098 5.37e-52 190.0 COG2094@1|root,arCOG04295@2157|Archaea,2Y0AE@28890|Euryarchaeota,2NB07@224756|Methanomicrobia 224756|Methanomicrobia L alkylbase DNA N-glycosylase activity mpg - 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco YYD2_k127_1534674_10 247490.KSU1_B0618 1.617e-48 180.0 COG1994@1|root,COG1994@2|Bacteria 2|Bacteria S metallopeptidase activity MA20_27160 - - ko:K06402 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M50 YYD2_k127_1590664_1 1173028.ANKO01000057_gene6232 1.026e-45 171.0 COG0664@1|root,COG0664@2|Bacteria,1G3SU@1117|Cyanobacteria,1H8VY@1150|Oscillatoriales 1117|Cyanobacteria K Cyclic nucleotide-binding domain - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding YYD2_k127_1590664_5 204669.Acid345_3258 7.357e-11 65.0 COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria,2JJXU@204432|Acidobacteriia 204432|Acidobacteriia S PFAM Iron sulphur-containing domain, CDGSH-type - - - - - - - - - - - - zf-CDGSH YYD2_k127_1590664_4 1313304.CALK_2567 9.978e-16 77.0 COG0230@1|root,COG0230@2|Bacteria 2|Bacteria J Ribosomal protein L34 rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 YYD2_k127_1590664_6 1125863.JAFN01000001_gene2688 1.065e-05 52.0 COG0594@1|root,COG0594@2|Bacteria 2|Bacteria J ribonuclease P activity rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P YYD2_k127_1590664_3 1121937.AUHJ01000008_gene2082 6.205e-22 98.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,4689Z@72275|Alteromonadaceae 1236|Gammaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K08998 - - - - ko00000 - - - Haemolytic YYD2_k127_1590664_0 194439.CT0006 1.809e-58 224.0 COG0706@1|root,COG0706@2|Bacteria,1FDGH@1090|Chlorobi 1090|Chlorobi U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas YYD2_k127_1590664_2 1304874.JAFY01000005_gene1178 4.011e-44 167.0 COG0486@1|root,COG0486@2|Bacteria,3TA4Z@508458|Synergistetes 508458|Synergistetes S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N YYD2_k127_1591308_0 1379698.RBG1_1C00001G0885 7.524e-60 213.0 COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria 2|Bacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338,ko:K08675 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002,ko03029 - - - AAA,LON_substr_bdg,Lon_C YYD2_k127_1591308_1 1380390.JIAT01000014_gene6288 6.639e-33 144.0 COG0028@1|root,COG0515@1|root,COG1470@1|root,COG2133@1|root,COG3291@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1470@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - Calx-beta,DUF4347,GSDH,Laminin_G_3,PA14,PKD YYD2_k127_1607288_1 635013.TherJR_1422 8.146e-11 73.0 COG3391@1|root,COG3391@2|Bacteria,1V2KS@1239|Firmicutes,24FSD@186801|Clostridia 186801|Clostridia S PFAM NHL repeat containing protein - - - - - - - - - - - - NHL YYD2_k127_1607288_2 667014.Thein_1798 5.089e-07 61.0 28WYN@1|root,2ZIXP@2|Bacteria,2GIB8@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 YYD2_k127_1607288_0 1379698.RBG1_1C00001G0830 3.333e-139 450.0 COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria 2|Bacteria J elongation factor G fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 YYD2_k127_1612940_2 521674.Plim_2153 2.751e-133 432.0 COG0191@1|root,COG0191@2|Bacteria,2IYZ9@203682|Planctomycetes 203682|Planctomycetes G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase YYD2_k127_1612940_0 344747.PM8797T_17839 0.0 1157.0 COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes 203682|Planctomycetes C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C YYD2_k127_1612940_5 1297581.H919_10843 2.878e-52 196.0 COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,4HAV8@91061|Bacilli,21W08@150247|Anoxybacillus 91061|Bacilli I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.29 - iYO844.BSU00460 GHMP_kinases_C,GHMP_kinases_N YYD2_k127_1612940_8 1379698.RBG1_1C00001G0639 6.076e-28 116.0 COG2088@1|root,COG2088@2|Bacteria,2NQ05@2323|unclassified Bacteria 2|Bacteria D SpoVG spoVG - - ko:K06412 - - - - ko00000 - - - SpoVG YYD2_k127_1612940_9 1399774.JDWH01000007_gene1591 0.0004185 47.0 2EFWG@1|root,339NR@2|Bacteria,1NIWH@1224|Proteobacteria,1SHRN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_1612940_3 517418.Ctha_2284 1.338e-117 386.0 COG0462@1|root,COG0462@2|Bacteria,1FD7M@1090|Chlorobi 1090|Chlorobi F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N YYD2_k127_1612940_6 1379698.RBG1_1C00001G0172 1.122e-46 177.0 COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria 2|Bacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C YYD2_k127_1612940_4 1379698.RBG1_1C00001G1816 2.661e-90 323.0 COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NR9R@2323|unclassified Bacteria 2|Bacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - DUF2723,PMT_2,TPR_8 YYD2_k127_1612940_1 1163617.SCD_n00428 6.211e-188 599.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria 28216|Betaproteobacteria T Bacterial protein of unknown function (DUF853) yjgR - - ko:K06915 - - - - ko00000 - - - DUF853 YYD2_k127_1612940_7 517417.Cpar_1143 4.154e-46 171.0 2CG47@1|root,2ZAEC@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1640532_2 1144313.PMI10_01181 2.043e-72 247.0 COG0346@1|root,COG0346@2|Bacteria,4NNNG@976|Bacteroidetes,1I1XF@117743|Flavobacteriia,2NWAI@237|Flavobacterium 976|Bacteroidetes E Glyoxalase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase YYD2_k127_1640532_7 572547.Amico_1898 2.023e-29 123.0 COG4585@1|root,COG4936@1|root,COG4585@2|Bacteria,COG4936@2|Bacteria,3TAQ1@508458|Synergistetes 508458|Synergistetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,PAS_4 YYD2_k127_1640532_0 1379698.RBG1_1C00001G0616 4.116e-108 363.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - - - - - - - - - - F5_F8_type_C,Peptidase_M6 YYD2_k127_1640532_5 665959.HMPREF1013_04214 1.547e-46 173.0 COG2318@1|root,COG2318@2|Bacteria,1V6MV@1239|Firmicutes,4HH68@91061|Bacilli,1ZFX8@1386|Bacillus 91061|Bacilli S DinB superfamily - - - - - - - - - - - - DinB_2 YYD2_k127_1640532_11 1032480.MLP_33800 4.845e-16 91.0 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding - - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 YYD2_k127_1640532_9 1004149.AFOE01000028_gene1803 1.106e-26 126.0 COG1044@1|root,COG1044@2|Bacteria,4PNZT@976|Bacteroidetes,1IKCC@117743|Flavobacteriia 976|Bacteroidetes M chitinase - - - - - - - - - - - - - YYD2_k127_1640532_12 421531.IX38_00975 6.138e-10 72.0 COG5295@1|root,COG5295@2|Bacteria,4NHCC@976|Bacteroidetes,1I2VF@117743|Flavobacteriia,3ZUIF@59732|Chryseobacterium 976|Bacteroidetes UW Hep Hag repeat protein - - - - - - - - - - - - Collagen YYD2_k127_1640532_6 1379698.RBG1_1C00001G0272 4.262e-43 164.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - - - - - - - - - - - AHSA1,DUF2505 YYD2_k127_1640532_10 1449346.JQMO01000002_gene173 5.718e-18 89.0 COG1917@1|root,COG1917@2|Bacteria,2IQ74@201174|Actinobacteria 201174|Actinobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - YYD2_k127_1640532_3 498211.CJA_2994 3.279e-68 236.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1FFXM@10|Cellvibrio 1236|Gammaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind YYD2_k127_1640532_8 694427.Palpr_2946 2.688e-27 115.0 2BFHQ@1|root,329BH@2|Bacteria,4P73M@976|Bacteroidetes,2FZWT@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_1640532_4 1174504.AJTN02000214_gene2464 1.999e-48 181.0 COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,4HFXF@91061|Bacilli,1ZCU9@1386|Bacillus 91061|Bacilli S Belongs to the UPF0312 family - - - - - - - - - - - - YceI YYD2_k127_1640532_1 1379698.RBG1_1C00001G0830 1.857e-75 264.0 COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria 2|Bacteria J elongation factor G fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 YYD2_k127_1686947_10 1379698.RBG1_1C00001G1241 4.809e-35 141.0 COG0613@1|root,COG0613@2|Bacteria,2NPWD@2323|unclassified Bacteria 2|Bacteria S PHP domain protein - - - - - - - - - - - - PHP YYD2_k127_1686947_6 1379698.RBG1_1C00001G1051 1.6e-76 260.0 COG0377@1|root,COG0377@2|Bacteria,2NP84@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 YYD2_k127_1686947_9 1379698.RBG1_1C00001G1052 2.158e-37 146.0 COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa YYD2_k127_1686947_4 1379698.RBG1_1C00001G1053 9.409e-166 529.0 COG0649@1|root,COG0649@2|Bacteria,2NNWG@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa YYD2_k127_1686947_8 1379698.RBG1_1C00001G1054 2.303e-48 177.0 COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria 2|Bacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.6.5.3 ko:K00334,ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx YYD2_k127_1686947_3 1379698.RBG1_1C00001G1055 1.338e-168 540.0 COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB YYD2_k127_1686947_2 1379698.RBG1_1C00001G1056 7.736e-176 581.0 COG3383@1|root,COG3383@2|Bacteria,2NNQ6@2323|unclassified Bacteria 2|Bacteria C Molydopterin dinucleotide binding domain hcnA - 1.17.1.9,1.4.99.5,1.5.3.1 ko:K00123,ko:K00302,ko:K10814 ko00260,ko00460,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,map00260,map00460,map00630,map00680,map01100,map01110,map01120,map01200 - R00374,R00519,R00610,R05704 RC00060,RC00557,RC02796,RC02808 ko00000,ko00001,ko01000,ko02042 - - - Fer2_4 YYD2_k127_1686947_5 1379698.RBG1_1C00001G1057 2.635e-121 398.0 COG1005@1|root,COG1005@2|Bacteria,2NNTT@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh YYD2_k127_1686947_7 1379698.RBG1_1C00001G1875 8.872e-68 234.0 COG1143@1|root,COG1143@2|Bacteria,2NPQR@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 ko:K00337,ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iNJ661.Rv3153 Fer4 YYD2_k127_1686947_12 1379698.RBG1_1C00001G1058 7.83e-30 128.0 COG0839@1|root,COG0839@2|Bacteria,2NPUC@2323|unclassified Bacteria 2|Bacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 YYD2_k127_1686947_11 237368.SCABRO_02000 4.831e-31 124.0 COG0713@1|root,COG0713@2|Bacteria,2J0GU@203682|Planctomycetes 203682|Planctomycetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 YYD2_k127_1686947_0 1379698.RBG1_1C00001G1060 3.57e-241 761.0 COG1009@1|root,COG1009@2|Bacteria,2NNU6@2323|unclassified Bacteria 2|Bacteria CP NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N YYD2_k127_1686947_1 1379698.RBG1_1C00001G1061 2.158e-213 674.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M YYD2_k127_1686947_13 290397.Adeh_1557 3.488e-12 68.0 COG0695@1|root,COG0695@2|Bacteria,1P8SJ@1224|Proteobacteria,42XTX@68525|delta/epsilon subdivisions 1224|Proteobacteria O Glutaredoxin - - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin YYD2_k127_1719941_2 1131462.DCF50_p2891 1.224e-12 68.0 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,261W1@186807|Peptococcaceae 186801|Clostridia G PFAM Ribose galactose isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB YYD2_k127_1719941_0 204669.Acid345_0712 3.019e-128 417.0 COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 YYD2_k127_1719941_1 1382356.JQMP01000001_gene1206 1.507e-42 163.0 COG1268@1|root,COG1268@2|Bacteria,2GBUZ@200795|Chloroflexi,27YWE@189775|Thermomicrobia 189775|Thermomicrobia S BioY family - - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY YYD2_k127_1723521_2 1379698.RBG1_1C00001G0535 5.812e-66 235.0 COG0266@1|root,COG0266@2|Bacteria,2NPGY@2323|unclassified Bacteria 2|Bacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS YYD2_k127_1723521_0 1379698.RBG1_1C00001G0182 5.475e-75 263.0 COG0340@1|root,COG0340@2|Bacteria,2NPG2@2323|unclassified Bacteria 2|Bacteria H biotin acetyl-CoA-carboxylase ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 YYD2_k127_1723521_1 357808.RoseRS_0439 4.366e-71 246.0 COG0157@1|root,COG0157@2|Bacteria,2G6GJ@200795|Chloroflexi,375H1@32061|Chloroflexia 32061|Chloroflexia H Belongs to the NadC ModD family - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N YYD2_k127_1740949_0 768710.DesyoDRAFT_5269 2.407e-84 284.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,2600A@186807|Peptococcaceae 186801|Clostridia G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N YYD2_k127_1740949_1 1408312.JNJS01000006_gene771 1.078e-73 263.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,24A6D@186801|Clostridia 186801|Clostridia C Radical SAM domain protein - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM YYD2_k127_1757853_4 861299.J421_1405 4.982e-20 93.0 2A4E9@1|root,2ZJRI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1757853_6 1170562.Cal6303_4322 4.286e-07 57.0 2DNT7@1|root,32Z0Z@2|Bacteria,1G93V@1117|Cyanobacteria 1117|Cyanobacteria S Cysteine-rich CPXCG - - - - - - - - - - - - Cys_rich_CPXG YYD2_k127_1757853_2 1303518.CCALI_00586 2.708e-44 179.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - PMT_2 YYD2_k127_1757853_5 1121106.JQKB01000059_gene4749 4.886e-18 94.0 COG0454@1|root,COG0456@2|Bacteria,1R418@1224|Proteobacteria,2U1QH@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 YYD2_k127_1757853_3 429009.Adeg_1906 3.521e-20 99.0 COG1959@1|root,COG1959@2|Bacteria,1UT43@1239|Firmicutes,2518T@186801|Clostridia,42ID9@68295|Thermoanaerobacterales 186801|Clostridia K Transcriptional regulator - - - - - - - - - - - - Rrf2 YYD2_k127_1757853_1 1118058.CAGY01000008_gene1489 2.755e-104 351.0 COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4D45F@85005|Actinomycetales 201174|Actinobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0008150,GO:0040007 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA YYD2_k127_1757853_0 457570.Nther_0001 1.304e-114 382.0 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia 186801|Clostridia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N YYD2_k127_1802646_0 1379698.RBG1_1C00001G0584 0.0 1064.0 COG2373@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG3386@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.4.24.40 ko:K01406,ko:K14274,ko:K20276,ko:K21449 ko00040,ko01503,ko02024,map00040,map01503,map02024 - R02427 RC00713 ko00000,ko00001,ko01000,ko01002,ko02000 1.B.40.2 - - Calx-beta,DUF4347,He_PIG,Ice_nucleation,SGL YYD2_k127_1802646_1 1379698.RBG1_1C00001G0584 5.144e-82 297.0 COG2373@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG3386@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.4.24.40 ko:K01406,ko:K14274,ko:K20276,ko:K21449 ko00040,ko01503,ko02024,map00040,map01503,map02024 - R02427 RC00713 ko00000,ko00001,ko01000,ko01002,ko02000 1.B.40.2 - - Calx-beta,DUF4347,He_PIG,Ice_nucleation,SGL YYD2_k127_1843148_1 935948.KE386495_gene1661 3.583e-115 386.0 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,42F49@68295|Thermoanaerobacterales 186801|Clostridia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N YYD2_k127_1843148_0 1379698.RBG1_1C00001G0265 2.945e-124 407.0 COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria 2|Bacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 ko:K02338,ko:K03610 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03036,ko03400,ko04812 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 YYD2_k127_1896565_11 882.DVU_1461 1.556e-41 167.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2M7UJ@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH YYD2_k127_1896565_8 1408433.JHXV01000019_gene1919 4.269e-75 264.0 COG0181@1|root,COG0181@2|Bacteria,4NHH4@976|Bacteroidetes,1HXKZ@117743|Flavobacteriia,2PB12@246874|Cryomorphaceae 976|Bacteroidetes H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - HEM4,Porphobil_deam,Porphobil_deamC YYD2_k127_1896565_12 866895.HBHAL_3678 3.948e-21 102.0 COG1587@1|root,COG1587@2|Bacteria,1UHSJ@1239|Firmicutes,4HFY4@91061|Bacilli,3NE80@45667|Halobacillus 91061|Bacilli H Uroporphyrinogen-III synthase HemD hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 YYD2_k127_1896565_6 929556.Solca_2810 9.99e-114 375.0 COG0113@1|root,COG0113@2|Bacteria,4NFW6@976|Bacteroidetes,1INPZ@117747|Sphingobacteriia 976|Bacteroidetes H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD YYD2_k127_1896565_1 1229276.DI53_2263 2.302e-149 484.0 COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,1INWD@117747|Sphingobacteriia 976|Bacteroidetes H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 YYD2_k127_1896565_7 653733.Selin_2337 3.922e-83 288.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0016 URO-D YYD2_k127_1896565_3 404589.Anae109_1129 5.546e-127 421.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2WMB0@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN - - - - - - - - - - - HemN_C,Radical_SAM YYD2_k127_1896565_9 1232410.KI421415_gene3101 3.472e-69 249.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,43RXT@69541|Desulfuromonadales 28221|Deltaproteobacteria H Ferrochelatase hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase YYD2_k127_1896565_4 243231.GSU0012 9.741e-119 396.0 COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,43SUB@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase YYD2_k127_1896565_5 1382358.JHVN01000007_gene307 3.383e-114 379.0 COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,4HA9W@91061|Bacilli,21V54@150247|Anoxybacillus 1239|Firmicutes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N YYD2_k127_1896565_2 1379698.RBG1_1C00001G1075 2.758e-147 481.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 YYD2_k127_1896565_0 1379698.RBG1_1C00001G1076 0.0 1411.0 COG3696@1|root,COG3696@2|Bacteria,2NP07@2323|unclassified Bacteria 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran YYD2_k127_1896565_10 1210884.HG799463_gene9843 1.039e-65 227.0 COG3256@1|root,COG3256@2|Bacteria,2J2IF@203682|Planctomycetes 203682|Planctomycetes P Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 YYD2_k127_1921104_11 1280390.CBQR020000067_gene1407 4.321e-51 186.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,26QQJ@186822|Paenibacillaceae 91061|Bacilli F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS YYD2_k127_1921104_16 1379698.RBG1_1C00001G0825 1.419e-08 66.0 28P4Q@1|root,2ZBZV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1921104_15 1121930.AQXG01000003_gene2491 2.001e-12 78.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - PSCyt1 YYD2_k127_1921104_13 1288963.ADIS_3055 1.383e-14 83.0 COG2353@1|root,COG2353@2|Bacteria 2|Bacteria O YceI-like domain - - - - - - - - - - - - YceI YYD2_k127_1921104_14 880073.Calab_0883 4.622e-13 75.0 COG2922@1|root,COG2922@2|Bacteria 2|Bacteria S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 YYD2_k127_1921104_7 1196029.ALIM01000014_gene3236 1.365e-109 368.0 COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4HAK8@91061|Bacilli,1ZD3R@1386|Bacillus 91061|Bacilli H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein YYD2_k127_1921104_10 1379698.RBG1_1C00001G0976 2.337e-67 239.0 COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria 2|Bacteria L Uracil DNA glycosylase superfamily ung - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG YYD2_k127_1921104_4 56780.SYN_00640 1.41e-127 423.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MQ50@213462|Syntrophobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C YYD2_k127_1921104_9 1379698.RBG1_1C00001G0978 3.19e-69 243.0 COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE YYD2_k127_1921104_8 1379698.RBG1_1C00001G0979 5.716e-81 277.0 COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran YYD2_k127_1921104_3 796606.BMMGA3_00555 1.764e-134 443.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,1ZB8H@1386|Bacillus 91061|Bacilli O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI YYD2_k127_1921104_6 485918.Cpin_6918 4.673e-116 386.0 COG0343@1|root,COG0343@2|Bacteria,4NE15@976|Bacteroidetes,1INNJ@117747|Sphingobacteriia 976|Bacteroidetes J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT YYD2_k127_1921104_12 344747.PM8797T_06170 8.388e-42 162.0 COG0122@1|root,COG0122@2|Bacteria,2J036@203682|Planctomycetes 203682|Planctomycetes L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase - - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD YYD2_k127_1921104_0 1379698.RBG1_1C00001G0471 5.506e-219 689.0 COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria 2|Bacteria C Belongs to the aldehyde dehydrogenase family ycbD - 1.2.1.3 ko:K00128,ko:K22187 ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh YYD2_k127_1921104_1 880073.Calab_0633 1.163e-201 639.0 COG2403@1|root,COG2403@2|Bacteria,2NNTB@2323|unclassified Bacteria 2|Bacteria S cyclic 2,3-diphosphoglycerate synthetase activity cpgS - - ko:K05716 - - R03298 RC00900 ko00000,ko01000 - - - cobW YYD2_k127_1921104_5 1379698.RBG1_1C00001G0473 5.448e-118 389.0 COG0549@1|root,COG0549@2|Bacteria,2NNKM@2323|unclassified Bacteria 2|Bacteria E Amino acid kinase family arcC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_3652,iE2348C_1286.E2348C_0454,iECABU_c1320.ECABU_c31550,iECED1_1282.ECED1_0540,iECED1_1282.ECED1_3334,iECIAI39_1322.ECIAI39_3289,iECNA114_1301.ECNA114_2915,iECOK1_1307.ECOK1_3260,iECS88_1305.ECS88_3153,iECSF_1327.ECSF_2670,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iHN637.CLJU_RS13830,iJN746.PP_0999,iUMN146_1321.UM146_02150,iUTI89_1310.UTI89_C3259,ic_1306.c3452 AA_kinase YYD2_k127_1921104_2 1379698.RBG1_1C00001G0474 1.498e-149 486.0 COG0617@1|root,COG0617@2|Bacteria,2NPB4@2323|unclassified Bacteria 2|Bacteria J Poly A polymerase head domain cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 YYD2_k127_192950_8 1229780.BN381_130143 1.989e-11 65.0 2DREZ@1|root,33BFB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_192950_1 1123242.JH636435_gene2052 1.305e-119 400.0 COG0475@1|root,COG0475@2|Bacteria,2IZ8F@203682|Planctomycetes 203682|Planctomycetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger YYD2_k127_192950_3 240015.ACP_2713 2.172e-91 308.0 COG1291@1|root,COG1291@2|Bacteria,3Y3Y8@57723|Acidobacteria,2JI9S@204432|Acidobacteriia 204432|Acidobacteriia N MotA/TolQ/ExbB proton channel family - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB YYD2_k127_192950_6 909663.KI867150_gene569 1.32e-60 219.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,42S6Q@68525|delta/epsilon subdivisions,2WNX0@28221|Deltaproteobacteria,2MRWK@213462|Syntrophobacterales 28221|Deltaproteobacteria N Membrane MotB of proton-channel complex MotA/MotB - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA YYD2_k127_192950_0 373903.Hore_21200 1.46e-265 856.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,3WA6U@53433|Halanaerobiales 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF YYD2_k127_192950_7 379066.GAU_1615 1.548e-41 168.0 COG0438@1|root,COG0438@2|Bacteria,1ZSTJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 YYD2_k127_192950_5 694427.Palpr_0129 3.835e-66 237.0 COG1562@1|root,COG1562@2|Bacteria 2|Bacteria I ergosterol biosynthetic process - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY YYD2_k127_192950_2 1379698.RBG1_1C00001G0415 9.255e-112 376.0 COG5316@1|root,COG5316@2|Bacteria,2NPBR@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 YYD2_k127_192950_9 582744.Msip34_0836 5.595e-05 55.0 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VJNV@28216|Betaproteobacteria 28216|Betaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_16,TPR_2,TPR_8 YYD2_k127_192950_4 518766.Rmar_2052 9.567e-91 318.0 COG1198@1|root,COG1198@2|Bacteria,4NFHB@976|Bacteroidetes,1FJ34@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII YYD2_k127_1933472_9 1042163.BRLA_c013830 1.556e-64 229.0 COG1108@1|root,COG1108@2|Bacteria,1TPZB@1239|Firmicutes,4HBD7@91061|Bacilli,26QRV@186822|Paenibacillaceae 91061|Bacilli P ABC transporter mntC - - ko:K11709,ko:K19976 ko02010,map02010 M00319,M00792 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.15 - - ABC-3 YYD2_k127_1933472_2 1237149.C900_05808 8.846e-116 387.0 COG1108@1|root,COG1321@1|root,COG1108@2|Bacteria,COG1321@2|Bacteria,4NH3D@976|Bacteroidetes,47MU3@768503|Cytophagia 976|Bacteroidetes KP ABC 3 transport family mntC - - ko:K11708 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ABC-3,Fe_dep_repr_C YYD2_k127_1933472_4 153721.MYP_4042 8.851e-110 359.0 COG1121@1|root,COG1121@2|Bacteria,4NHZ9@976|Bacteroidetes,47KSI@768503|Cytophagia 976|Bacteroidetes P ATPases associated with a variety of cellular activities troB - 3.6.3.35 ko:K11710,ko:K19973 ko02010,map02010 M00319,M00792 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.15.15 - - ABC_tran YYD2_k127_1933472_5 649747.HMPREF0083_00441 1.608e-104 347.0 COG0803@1|root,COG0803@2|Bacteria,1TRKU@1239|Firmicutes,4HAKT@91061|Bacilli,26R1W@186822|Paenibacillaceae 91061|Bacilli P Belongs to the bacterial solute-binding protein 9 family troA - - ko:K11707 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ZnuA YYD2_k127_1933472_14 69014.TK0107 3.739e-19 93.0 COG1321@1|root,arCOG02100@2157|Archaea,2XZV0@28890|Euryarchaeota,245GN@183968|Thermococci 183968|Thermococci K Helix-turn-helix diphteria tox regulatory element - - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress YYD2_k127_1933472_7 1382304.JNIL01000001_gene1095 2.338e-90 311.0 COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,4H9WQ@91061|Bacilli,278YX@186823|Alicyclobacillaceae 91061|Bacilli E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 YYD2_k127_1933472_10 1379698.RBG1_1C00001G0220 4.024e-54 211.0 COG3292@1|root,COG3292@2|Bacteria,2NR5N@2323|unclassified Bacteria 2|Bacteria T Two component regulator propeller - - - ko:K19693 - - - - ko00000,ko03000 - - - HATPase_c,HTH_18,HisKA,Response_reg YYD2_k127_1933472_15 177439.DP1640 8.368e-06 57.0 COG4856@1|root,COG4856@2|Bacteria,1REEU@1224|Proteobacteria,42RY2@68525|delta/epsilon subdivisions,2WNZH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM YbbR family protein - - - - - - - - - - - - YbbR YYD2_k127_1933472_3 1379698.RBG1_1C00001G0218 1.107e-115 381.0 COG0533@1|root,COG0533@2|Bacteria,2NNXP@2323|unclassified Bacteria 2|Bacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Peptidase_M22 YYD2_k127_1933472_0 880073.Calab_2282 2.217e-170 565.0 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2NNKI@2323|unclassified Bacteria 2|Bacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - DUF2344,Radical_SAM YYD2_k127_1933472_6 1379698.RBG1_1C00001G0941 1.565e-96 333.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2NP36@2323|unclassified Bacteria 2|Bacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB YYD2_k127_1933472_13 574087.Acear_1434 1.383e-24 113.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WAHY@53433|Halanaerobiales 186801|Clostridia T Protein kinase domain prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase YYD2_k127_1933472_17 1122134.KB893650_gene53 6.991e-05 54.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XJPG@135619|Oceanospirillales 135619|Oceanospirillales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR YYD2_k127_1933472_11 234267.Acid_3432 6.899e-39 158.0 COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria 57723|Acidobacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA,GAF_3,SpoIIE YYD2_k127_1933472_12 316067.Geob_0486 1.058e-24 111.0 COG2703@1|root,COG2703@2|Bacteria,1RK9A@1224|Proteobacteria,42X8X@68525|delta/epsilon subdivisions,2WR9M@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM Hemerythrin HHE cation binding domain protein - - - ko:K07216 - - - - ko00000 - - - Hemerythrin YYD2_k127_1933472_8 1379698.RBG1_1C00001G1819 7.413e-87 319.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1933472_16 1132442.KB889752_gene2135 6.241e-05 52.0 COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4HIQ3@91061|Bacilli,1ZCW1@1386|Bacillus 91061|Bacilli CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c resA GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - - - - - - - - - - AhpC-TSA YYD2_k127_1933472_1 1379698.RBG1_1C00001G1888 5.668e-134 432.0 COG0468@1|root,COG0468@2|Bacteria,2NNYW@2323|unclassified Bacteria 2|Bacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA YYD2_k127_1956372_0 1379698.RBG1_1C00001G1395 2.195e-93 312.0 28IS3@1|root,2Z8R9@2|Bacteria 2|Bacteria S Psort location Cytoplasmic, score - - - - - - - - - - - - Phage_capsid YYD2_k127_1964620_12 1521187.JPIM01000118_gene814 1.835e-13 78.0 COG0607@1|root,COG0607@2|Bacteria 2|Bacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - Rhodanese YYD2_k127_1964620_7 1379698.RBG1_1C00001G0331 3.172e-64 232.0 COG2067@1|root,COG2067@2|Bacteria,2NPV7@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein porQ - - - - - - - - - - - PorP_SprF YYD2_k127_1964620_11 1379698.RBG1_1C00001G0332 9.624e-23 105.0 COG2980@1|root,COG2980@2|Bacteria,2NQ1I@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences lptE GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788 LptE YYD2_k127_1964620_5 1268072.PSAB_13070 2.428e-123 407.0 COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,4HAVY@91061|Bacilli,26RUZ@186822|Paenibacillaceae 91061|Bacilli Q Amidohydrolase family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 YYD2_k127_1964620_1 1379698.RBG1_1C00001G0334 2.364e-259 808.0 COG2987@1|root,COG2987@2|Bacteria,2NP09@2323|unclassified Bacteria 2|Bacteria E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016153,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_0688 Urocanase,Urocanase_C,Urocanase_N YYD2_k127_1964620_9 1459636.NTE_00759 7.118e-37 146.0 COG1027@1|root,COG1670@1|root,arCOG00842@2157|Archaea,arCOG01750@2157|Archaea,41S9C@651137|Thaumarchaeota 651137|Thaumarchaeota E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 YYD2_k127_1964620_10 247490.KSU1_D0285 1.07e-25 113.0 2CA4A@1|root,32RQK@2|Bacteria,2J0BM@203682|Planctomycetes 203682|Planctomycetes S Domain of unknown function (DUF4416) - - - - - - - - - - - - DUF4416 YYD2_k127_1964620_4 1379698.RBG1_1C00001G0341 3.397e-141 463.0 COG0766@1|root,COG0766@2|Bacteria,2NNUV@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase YYD2_k127_1964620_0 1379698.RBG1_1C00001G0340 6.934e-312 990.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2 YYD2_k127_1964620_2 690850.Desaf_0617 2.436e-229 737.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C YYD2_k127_1964620_8 945713.IALB_0759 3.688e-60 220.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - PorP_SprF YYD2_k127_1964620_3 1191523.MROS_0285 1.308e-153 524.0 2E09V@1|root,32VXB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_1964620_6 945713.IALB_0757 2.14e-73 264.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD2_k127_1997578_5 477974.Daud_0844 6.801e-23 108.0 COG1525@1|root,COG2169@1|root,COG1525@2|Bacteria,COG2169@2|Bacteria,1VASF@1239|Firmicutes,24G14@186801|Clostridia,261ZZ@186807|Peptococcaceae 186801|Clostridia L PFAM nuclease (SNase nucH - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - Ada_Zn_binding,SNase YYD2_k127_1997578_0 1379698.RBG1_1C00001G1230 4.336e-113 376.0 COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria 2|Bacteria J tRNA synthetases class I (W and Y) trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b YYD2_k127_1997578_2 1379698.RBG1_1C00001G1229 9.356e-52 192.0 COG1354@1|root,COG1354@2|Bacteria,2NPM8@2323|unclassified Bacteria 2|Bacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA YYD2_k127_1997578_3 1191523.MROS_2552 5.494e-48 182.0 COG1386@1|root,COG1386@2|Bacteria 2|Bacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB YYD2_k127_1997578_1 1209989.TepiRe1_1463 1.413e-61 220.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales 186801|Clostridia J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 YYD2_k127_1997578_9 714943.Mucpa_2768 3.667e-12 77.0 COG0823@1|root,COG1520@1|root,COG4447@1|root,COG5295@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria,COG4447@2|Bacteria,COG5295@2|Bacteria,4NRP7@976|Bacteroidetes,1IU78@117747|Sphingobacteriia 976|Bacteroidetes UW protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - BNR,PSII_BNR YYD2_k127_1997578_4 1266998.ATUJ01000001_gene2645 5.661e-24 111.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,2PUUC@265|Paracoccus 28211|Alphaproteobacteria D ATPases associated with a variety of cellular activities ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran YYD2_k127_1997578_8 269799.Gmet_1855 1e-16 91.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,43BBA@68525|delta/epsilon subdivisions,2X6QG@28221|Deltaproteobacteria,43T0S@69541|Desulfuromonadales 28221|Deltaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX YYD2_k127_1997578_7 1297742.A176_05290 1.973e-17 95.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,42N32@68525|delta/epsilon subdivisions,2WKBN@28221|Deltaproteobacteria,2YVR8@29|Myxococcales 28221|Deltaproteobacteria D Peptidase family M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23,SH3_3 YYD2_k127_1997578_6 1408473.JHXO01000001_gene2268 8e-23 107.0 COG0470@1|root,COG0470@2|Bacteria,4NEYF@976|Bacteroidetes,2FPCQ@200643|Bacteroidia 976|Bacteroidetes L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 YYD2_k127_2010400_2 411901.BACCAC_02037 1.085e-115 383.0 COG0404@1|root,COG0404@2|Bacteria,4NF7S@976|Bacteroidetes,2FPDM@200643|Bacteroidia,4AMEQ@815|Bacteroidaceae 976|Bacteroidetes H The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C YYD2_k127_2010400_8 1379698.RBG1_1C00001G0649 4.639e-52 193.0 COG2045@1|root,COG2045@2|Bacteria,2NPF1@2323|unclassified Bacteria 2|Bacteria H Belongs to the ComB family comB GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp YYD2_k127_2010400_14 1379698.RBG1_1C00001G0207 1.116e-37 162.0 COG0457@1|root,COG0457@2|Bacteria 1379698.RBG1_1C00001G0207|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - YYD2_k127_2010400_3 1379698.RBG1_1C00001G0208 3.336e-106 370.0 COG2304@1|root,COG2304@2|Bacteria,2NPT8@2323|unclassified Bacteria 2|Bacteria S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA YYD2_k127_2010400_0 1545701.LACWKB10_1322 2.737e-126 426.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HBVV@91061|Bacilli,3F3QI@33958|Lactobacillaceae 91061|Bacilli S ABC transporter, ATP-binding protein ydiF - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn YYD2_k127_2010400_21 237368.SCABRO_01366 3.752e-16 86.0 COG0655@1|root,COG0655@2|Bacteria,2J3H1@203682|Planctomycetes 203682|Planctomycetes S Flavodoxin-like fold - - - - - - - - - - - - FMN_red YYD2_k127_2010400_16 1396141.BATP01000007_gene5722 3.774e-34 139.0 COG0500@1|root,COG2226@2|Bacteria,46V7M@74201|Verrucomicrobia 74201|Verrucomicrobia Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_25 YYD2_k127_2010400_19 269799.Gmet_0377 8.03e-25 108.0 COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2WRGA@28221|Deltaproteobacteria,43VM9@69541|Desulfuromonadales 28221|Deltaproteobacteria J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 YYD2_k127_2010400_6 1379698.RBG1_1C00001G0691 3.262e-92 312.0 COG3872@1|root,COG3872@2|Bacteria,2NP59@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1385) prmC - - ko:K09153 - - - - ko00000 - - - DUF1385 YYD2_k127_2010400_1 1379698.RBG1_1C00001G0692 3.529e-126 413.0 COG0216@1|root,COG0216@2|Bacteria,2NNKY@2323|unclassified Bacteria 2|Bacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 YYD2_k127_2010400_22 1191523.MROS_1441 1.029e-15 89.0 2AMSR@1|root,31CP7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_2010400_9 580331.Thit_0125 6.585e-48 183.0 COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,42F18@68295|Thermoanaerobacterales 186801|Clostridia J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 YYD2_k127_2010400_7 459495.SPLC1_S011000 7.795e-63 222.0 COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,1H8MW@1150|Oscillatoriales 1117|Cyanobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD YYD2_k127_2010400_15 869213.JCM21142_72957 2.441e-37 146.0 2A42S@1|root,30SMP@2|Bacteria,4P40W@976|Bacteroidetes 976|Bacteroidetes S Nickel-containing superoxide dismutase - - - - - - - - - - - - Sod_Ni YYD2_k127_2010400_18 247490.KSU1_C0709 3.802e-29 124.0 COG1633@1|root,COG1633@2|Bacteria,2J3M5@203682|Planctomycetes 203682|Planctomycetes S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD2_k127_2010400_20 880073.Calab_2419 1.465e-22 110.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - Big_5 YYD2_k127_2010400_10 1499967.BAYZ01000074_gene2192 3.071e-46 178.0 COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria 2|Bacteria M Lipid A biosynthesis - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans YYD2_k127_2010400_13 1499967.BAYZ01000118_gene3248 1.327e-39 163.0 COG0845@1|root,COG0845@2|Bacteria,2NR8R@2323|unclassified Bacteria 2|Bacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K02005 - - - - ko00000 - - - HlyD_3,HlyD_D23 YYD2_k127_2010400_5 1336233.JAEH01000015_gene3232 5.628e-94 323.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1RMBY@1236|Gammaproteobacteria,2QAXR@267890|Shewanellaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_2010400_24 471870.BACINT_02916 1.53e-10 74.0 COG1538@1|root,COG1538@2|Bacteria,4NGXM@976|Bacteroidetes,2FMD9@200643|Bacteroidia,4AKU0@815|Bacteroidaceae 976|Bacteroidetes MU Psort location OuterMembrane, score - - - - - - - - - - - - OEP YYD2_k127_2010400_11 1121405.dsmv_0518 1.035e-45 179.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,2MIGM@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM lipopolysaccharide heptosyltransferase II - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 YYD2_k127_2010400_17 1379698.RBG1_1C00001G1508 4.805e-34 133.0 2E4KV@1|root,32ZFU@2|Bacteria,2NQ0D@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF3467) - - - - - - - - - - - - DUF3467 YYD2_k127_2010400_4 1379698.RBG1_1C00001G1507 1.266e-98 334.0 COG2870@1|root,COG2870@2|Bacteria,2NNUT@2323|unclassified Bacteria 2|Bacteria M pfkB family carbohydrate kinase rfaE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB YYD2_k127_2010400_12 667014.Thein_1023 3.611e-45 169.0 COG0388@1|root,COG0615@1|root,COG0388@2|Bacteria,COG0615@2|Bacteria,2GHDJ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria IM Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - - - - - - - - - - CN_hydrolase,CTP_transf_like YYD2_k127_2010400_23 1379270.AUXF01000006_gene31 1.384e-11 72.0 COG0457@1|root,COG0457@2|Bacteria,1ZTTU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 YYD2_k127_2084985_5 1379698.RBG1_1C00001G0965 1.48e-16 83.0 COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria 2|Bacteria E glutamine synthetase glnA2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N YYD2_k127_2084985_2 439235.Dalk_0201 5.655e-68 235.0 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42UR6@68525|delta/epsilon subdivisions,2WR1E@28221|Deltaproteobacteria,2MPYJ@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM Cytidine and deoxycytidylate deaminase zinc-binding region - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 YYD2_k127_2084985_4 1007105.PT7_1205 1.276e-36 151.0 COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,2VNMQ@28216|Betaproteobacteria,3T8Z8@506|Alcaligenaceae 28216|Betaproteobacteria F Phosphorylase superfamily - - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 YYD2_k127_2084985_6 203275.BFO_2676 9.714e-06 56.0 2FJRB@1|root,34BE7@2|Bacteria,4P5QR@976|Bacteroidetes,2FYTE@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_2084985_0 1379698.RBG1_1C00001G1759 1.69e-102 340.0 COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria 2|Bacteria O prohibitin homologues hflC - - - - - - - - - - - Band_7 YYD2_k127_2084985_1 289376.THEYE_A0592 2.527e-99 342.0 COG1030@1|root,COG1030@2|Bacteria,3J0WF@40117|Nitrospirae 40117|Nitrospirae O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD YYD2_k127_2084985_3 1379698.RBG1_1C00001G1761 1.365e-47 179.0 COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 YYD2_k127_2174719_3 1379698.RBG1_1C00001G1545 6.672e-81 276.0 COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria 2|Bacteria KT PglZ domain - - - - - - - - - - - - PglZ,Response_reg YYD2_k127_2174719_2 1379698.RBG1_1C00001G1544 1.838e-105 358.0 COG4191@1|root,COG4191@2|Bacteria,2NPC5@2323|unclassified Bacteria 2|Bacteria T Integral membrane sensor signal transduction histidine kinase vicK - 2.1.1.80,2.7.13.3,3.1.1.61 ko:K07709,ko:K13924 ko02020,ko02030,map02020,map02030 M00499,M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA YYD2_k127_2174719_0 224324.aq_298 7.128e-148 479.0 COG0172@1|root,COG0172@2|Bacteria,2G3RF@200783|Aquificae 200783|Aquificae J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b YYD2_k127_2174719_5 903818.KI912268_gene3171 6.186e-22 96.0 COG0227@1|root,COG0227@2|Bacteria,3Y5KC@57723|Acidobacteria 57723|Acidobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 YYD2_k127_2174719_1 1112274.KI911560_gene2244 1.644e-120 391.0 COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2VK6T@28216|Betaproteobacteria,2KP63@206350|Nitrosomonadales 206350|Nitrosomonadales G Major intrinsic protein - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP YYD2_k127_2174719_4 1379698.RBG1_1C00001G1345 1.936e-40 154.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria 2|Bacteria KT COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - GAF,GAF_2,HATPase_c_2,SSF,SpoIIE YYD2_k127_2187372_2 1379698.RBG1_1C00001G1550 1.545e-58 215.0 COG0285@1|root,COG0285@2|Bacteria,2NP60@2323|unclassified Bacteria 2|Bacteria H Belongs to the folylpolyglutamate synthase family folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0166,iSB619.SA_RS08370 Mur_ligase_C,Mur_ligase_M YYD2_k127_2187372_5 1379698.RBG1_1C00001G1550 7.932e-26 111.0 COG0285@1|root,COG0285@2|Bacteria,2NP60@2323|unclassified Bacteria 2|Bacteria H Belongs to the folylpolyglutamate synthase family folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0166,iSB619.SA_RS08370 Mur_ligase_C,Mur_ligase_M YYD2_k127_2187372_1 1379698.RBG1_1C00001G1549 6.745e-117 382.0 COG0777@1|root,COG0777@2|Bacteria,2NP40@2323|unclassified Bacteria 2|Bacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iJN678.accD,iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Carboxyl_trans YYD2_k127_2187372_4 1121335.Clst_2533 2.603e-27 118.0 COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,3WKHF@541000|Ruminococcaceae 186801|Clostridia K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 YYD2_k127_2187372_6 1321781.HMPREF1985_00642 3.233e-20 99.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4H47Z@909932|Negativicutes 909932|Negativicutes O Universal bacterial protein YeaZ yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 YYD2_k127_2187372_3 1410631.JHWZ01000001_gene964 4.234e-30 124.0 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,27MWC@186928|unclassified Lachnospiraceae 186801|Clostridia S Threonylcarbamoyl adenosine biosynthesis protein TsaE ydiB - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE YYD2_k127_2187372_0 1379698.RBG1_1C00001G1545 7.519e-180 577.0 COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria 2|Bacteria KT PglZ domain - - - - - - - - - - - - PglZ,Response_reg YYD2_k127_2202306_0 1379698.RBG1_1C00001G1080 4.984e-139 465.0 COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 YYD2_k127_2236829_6 1239962.C943_03877 5.503e-17 91.0 COG0823@1|root,COG0823@2|Bacteria,4NEPF@976|Bacteroidetes,47NVJ@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - CarbopepD_reg_2,CarboxypepD_reg,PD40 YYD2_k127_2236829_1 1379698.RBG1_1C00001G1066 4.669e-127 423.0 COG0260@1|root,COG0260@2|Bacteria,2NNKH@2323|unclassified Bacteria 2|Bacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N YYD2_k127_2236829_0 1536770.R50345_20750 3.454e-128 421.0 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4HA0H@91061|Bacilli,26QTH@186822|Paenibacillaceae 91061|Bacilli E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt YYD2_k127_2236829_4 396588.Tgr7_0663 2.665e-28 130.0 COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,1S3XV@1236|Gammaproteobacteria,1WVYJ@135613|Chromatiales 135613|Chromatiales T signal transduction protein - - - - - - - - - - - - HDOD YYD2_k127_2236829_5 1379698.RBG1_1C00001G1224 2.891e-25 124.0 COG0745@1|root,COG0745@2|Bacteria 1379698.RBG1_1C00001G1224|- T phosphorelay signal transduction system - - - - - - - - - - - - - YYD2_k127_2236829_2 1304880.JAGB01000001_gene243 6.331e-115 387.0 COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia 186801|Clostridia J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 YYD2_k127_2236829_3 945713.IALB_2321 3.641e-107 375.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process pepN1 - - - - - - - - - - - Peptidase_M1 YYD2_k127_2327951_3 1408813.AYMG01000001_gene3645 3.624e-10 63.0 COG0454@1|root,COG0456@2|Bacteria,4NQ7Z@976|Bacteroidetes,1ISWS@117747|Sphingobacteriia 976|Bacteroidetes K Acetyltransferase, gnat family - - - ko:K03829 - - - - ko00000,ko01000 - - - Acetyltransf_1 YYD2_k127_2327951_2 1379698.RBG1_1C00001G0105 2.265e-25 113.0 COG0597@1|root,COG0597@2|Bacteria,2NPU1@2323|unclassified Bacteria 2|Bacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 YYD2_k127_2327951_1 1379698.RBG1_1C00001G0104 3.147e-46 169.0 COG1734@1|root,COG1734@2|Bacteria,2NPX2@2323|unclassified Bacteria 2|Bacteria T Transcriptional regulator, TraR DksA family dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR YYD2_k127_2327951_0 1379698.RBG1_1C00001G0103 1.654e-274 871.0 COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria 2|Bacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 YYD2_k127_2339643_5 399795.CtesDRAFT_PD2168 5.892e-16 87.0 COG2067@1|root,COG2067@2|Bacteria,1RDE4@1224|Proteobacteria,2VVWG@28216|Betaproteobacteria 28216|Betaproteobacteria I long-chain fatty acid transport protein - - - - - - - - - - - - YfaZ YYD2_k127_2339643_3 1313172.YM304_31360 7.884e-90 305.0 COG0693@1|root,COG3119@1|root,COG0693@2|Bacteria,COG3119@2|Bacteria,2IA3D@201174|Actinobacteria 201174|Actinobacteria P Sulfatase - - - - - - - - - - - - Sulfatase YYD2_k127_2339643_4 1333998.M2A_0798 3.909e-71 259.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2U0BA@28211|Alphaproteobacteria,4BT4A@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_2 YYD2_k127_2339643_1 338966.Ppro_2179 8.607e-121 398.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,42P59@68525|delta/epsilon subdivisions,2WJUJ@28221|Deltaproteobacteria,43W2K@69541|Desulfuromonadales 28221|Deltaproteobacteria S Conserved hypothetical protein 698 - - - - - - - - - - - - Cons_hypoth698 YYD2_k127_2339643_0 1121104.AQXH01000003_gene311 4.67e-140 460.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,4NE2Y@976|Bacteroidetes,1IUW3@117747|Sphingobacteriia 976|Bacteroidetes P Rhodanese Homology Domain - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B,Rhodanese YYD2_k127_2339643_2 1231391.AMZF01000012_gene2675 2.083e-103 341.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,3T6UR@506|Alcaligenaceae 28216|Betaproteobacteria O C-terminal domain of 1-Cys peroxiredoxin lsfA - - - - - - - - - - - 1-cysPrx_C,AhpC-TSA YYD2_k127_235419_0 1379698.RBG1_1C00001G0971 1.122e-113 373.0 COG0152@1|root,COG0152@2|Bacteria,2NP0V@2323|unclassified Bacteria 2|Bacteria F SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 - - - SAICAR_synt YYD2_k127_235419_1 1385511.N783_07320 1.694e-110 369.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,2Y9WM@289201|Pontibacillus 91061|Bacilli F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS YYD2_k127_2355811_3 1444770.AF72_08550 2.199e-10 63.0 COG0475@1|root,COG0475@2|Bacteria,1RA3J@1224|Proteobacteria,1RWKQ@1236|Gammaproteobacteria,1X47M@135614|Xanthomonadales 135614|Xanthomonadales P Na h exchange protein - - - - - - - - - - - - Na_H_Exchanger YYD2_k127_2355811_1 891968.Anamo_1584 1.962e-199 627.0 COG0438@1|root,COG0438@2|Bacteria,3TAFG@508458|Synergistetes 508458|Synergistetes H PFAM glycosyl transferase group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 YYD2_k127_2355811_2 592015.HMPREF1705_00166 3.692e-66 232.0 COG0438@1|root,COG0438@2|Bacteria,3TC5G@508458|Synergistetes 508458|Synergistetes M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - YYD2_k127_2355811_0 891968.Anamo_1586 1.44e-244 776.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,3TA4P@508458|Synergistetes 508458|Synergistetes G PFAM glycosyl transferase family 20 - - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase YYD2_k127_235862_2 273068.TTE2389 1.44e-56 200.0 COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales 186801|Clostridia I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase YYD2_k127_235862_4 1237149.C900_01020 2.764e-20 97.0 COG4770@1|root,COG4770@2|Bacteria,4NQ86@976|Bacteroidetes,47QC5@768503|Cytophagia 976|Bacteroidetes I Acetyl propionyl-CoA carboxylase alpha subunit - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl YYD2_k127_235862_0 1168034.FH5T_18240 2.537e-178 575.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,2FMBN@200643|Bacteroidia 976|Bacteroidetes I Biotin carboxylase accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 YYD2_k127_235862_1 1379698.RBG1_1C00001G0988 9.42e-147 488.0 COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria 2|Bacteria C lyase activity - - 3.4.24.3 ko:K01387,ko:K03301 - - - - ko00000,ko01000,ko01002,ko02042 2.A.12 - - DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase YYD2_k127_235862_5 1173023.KE650771_gene4830 0.000238 52.0 COG1413@1|root,COG1413@2|Bacteria,1G511@1117|Cyanobacteria,1JJSP@1189|Stigonemataceae 1117|Cyanobacteria C HEAT repeat - - - - - - - - - - - - HEAT_2,HEAT_PBS YYD2_k127_235862_3 1379698.RBG1_1C00001G0990 3.269e-46 179.0 COG3359@1|root,COG3359@2|Bacteria,2NPCP@2323|unclassified Bacteria 2|Bacteria L RNase_H superfamily yprB - - ko:K07502 - - - - ko00000 - - - RNase_H_2 YYD2_k127_2362977_7 1144275.COCOR_06097 2.869e-31 127.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,2YU89@29|Myxococcales 28221|Deltaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8 YYD2_k127_2362977_4 1379698.RBG1_1C00001G0395 1.213e-88 304.0 COG0772@1|root,COG0772@2|Bacteria,2NP3P@2323|unclassified Bacteria 2|Bacteria D Belongs to the SEDS family ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 - FTSW_RODA_SPOVE YYD2_k127_2362977_5 1379698.RBG1_1C00001G0396 2.806e-80 290.0 COG0707@1|root,COG0707@2|Bacteria,2NP4Z@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 - R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - GT28 iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Glyco_tran_28_C,Glyco_transf_28 YYD2_k127_2362977_1 404380.Gbem_0492 1.599e-141 464.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M YYD2_k127_2362977_3 1379698.RBG1_1C00001G0399 2.598e-119 395.0 COG0849@1|root,COG0849@2|Bacteria,2NNU2@2323|unclassified Bacteria 2|Bacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA YYD2_k127_2362977_2 1379698.RBG1_1C00001G0400 6.081e-125 415.0 COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria 2|Bacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin YYD2_k127_2362977_8 1168034.FH5T_08145 7.264e-06 60.0 COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,2FQRG@200643|Bacteroidia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 YYD2_k127_2362977_0 1379698.RBG1_1C00001G1494 1.028e-147 481.0 COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria 2|Bacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 YYD2_k127_2362977_6 1047013.AQSP01000128_gene436 7.821e-37 141.0 COG0540@1|root,COG0540@2|Bacteria,2NNPZ@2323|unclassified Bacteria 2|Bacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU15490 OTCace,OTCace_N YYD2_k127_2385800_0 639282.DEFDS_1067 1.415e-193 610.0 COG1012@1|root,COG1012@2|Bacteria,2GEJJ@200930|Deferribacteres 200930|Deferribacteres C Aldehyde dehydrogenase family - - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh YYD2_k127_2385800_1 863365.XHC_4158 9.58e-39 148.0 COG1607@1|root,COG1607@2|Bacteria,1RHNU@1224|Proteobacteria,1S4SW@1236|Gammaproteobacteria,1XD3I@135614|Xanthomonadales 135614|Xanthomonadales I Thioesterase superfamily VL23_09840 - - - - - - - - - - - 4HBT YYD2_k127_2385800_2 983917.RGE_38700 6.337e-32 128.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase,Glyoxalase_2 YYD2_k127_2408517_0 1321778.HMPREF1982_00036 7.015e-114 369.0 COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,26881@186813|unclassified Clostridiales 186801|Clostridia EJ Psort location Cytoplasmic, score - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase YYD2_k127_2408517_2 118168.MC7420_3051 3.024e-29 126.0 COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales 1117|Cyanobacteria L Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 YYD2_k127_2408517_1 1121920.AUAU01000013_gene1722 1.066e-104 341.0 2CCI4@1|root,30BPJ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_2408517_3 1380394.JADL01000009_gene3346 9.343e-24 105.0 COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,2UCNX@28211|Alphaproteobacteria,2JXNC@204441|Rhodospirillales 204441|Rhodospirillales L GIY-YIG catalytic domain - - - - - - - - - - - - GIY-YIG YYD2_k127_2489636_4 1550091.JROE01000001_gene4032 1.553e-06 52.0 COG3591@1|root,COG3591@2|Bacteria,4NIMW@976|Bacteroidetes,1IQUI@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase S46 - - - - - - - - - - - - Peptidase_S46 YYD2_k127_2489636_2 642492.Clole_4234 9.9e-08 62.0 2F9S3@1|root,34222@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_2489636_3 459349.CLOAM1774 1.518e-06 60.0 2F9BU@1|root,341NU@2|Bacteria,2NR9C@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_2489636_1 648996.Theam_1519 1.943e-72 253.0 COG1694@1|root,COG3956@2|Bacteria,2G3T8@200783|Aquificae 200783|Aquificae S TIGRFAM MazG family protein mazG - - ko:K02499 - - - - ko00000,ko03036 - - - MazG YYD2_k127_2489636_0 1379698.RBG1_1C00001G0414 2.76e-227 714.0 COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria 2|Bacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iLJ478.TM1817 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 YYD2_k127_2492177_1 1379698.RBG1_1C00001G0098 1.359e-31 127.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - Response_reg YYD2_k127_2492177_0 945713.IALB_2869 6.515e-103 346.0 COG2262@1|root,COG2262@2|Bacteria 2|Bacteria O GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 YYD2_k127_2492177_2 1379698.RBG1_1C00001G0290 3.677e-28 129.0 COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 YYD2_k127_249740_0 326427.Cagg_0607 2.664e-102 347.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,2G64U@200795|Chloroflexi,374ZG@32061|Chloroflexia 32061|Chloroflexia P YidE YbjL duplication domain protein - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C YYD2_k127_249740_1 1163617.SCD_n02206 1.34e-69 243.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VJCP@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM SNARE associated Golgi protein dedA - - ko:K03975 - - - - ko00000 - - - SNARE_assoc YYD2_k127_249740_3 443144.GM21_1416 6.756e-06 54.0 COG1633@1|root,COG1633@2|Bacteria,1NG4N@1224|Proteobacteria,42W3T@68525|delta/epsilon subdivisions,2WSZ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD2_k127_249740_2 1379698.RBG1_1C00001G1529 1.446e-38 158.0 COG2304@1|root,COG2304@2|Bacteria,2NPUS@2323|unclassified Bacteria 2|Bacteria S IgA Peptidase M64 - - - - - - - - - - - - M64_N,Peptidase_M64 YYD2_k127_2498488_1 1379698.RBG1_1C00001G1725 8.262e-179 566.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran YYD2_k127_2498488_4 945713.IALB_0515 1.197e-64 227.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - AhpC-TSA YYD2_k127_2498488_0 251221.35214536 3.226e-192 623.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1G4UJ@1117|Cyanobacteria 1117|Cyanobacteria CO Disulphide bond corrector protein DsbC - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 YYD2_k127_2498488_2 686340.Metal_1682 1.206e-120 403.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RXW3@1236|Gammaproteobacteria,1XGS8@135618|Methylococcales 135618|Methylococcales E Sodium:solute symporter family - - - - - - - - - - - - SSF YYD2_k127_2498488_3 706587.Desti_1549 2.407e-68 240.0 COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,42UXR@68525|delta/epsilon subdivisions,2WQCT@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 YYD2_k127_2500501_3 1379698.RBG1_1C00001G0099 6.737e-53 206.0 COG1520@1|root,COG1520@2|Bacteria,2NQ51@2323|unclassified Bacteria 2|Bacteria O NHL repeat containing protein - - - - - - - - - - - - DUF5122,PQQ_2,SBBP YYD2_k127_2500501_1 880073.Calab_0988 1.247e-100 346.0 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2NPAA@2323|unclassified Bacteria 2|Bacteria S AMMECR1 - - - ko:K06990,ko:K09141 - - - - ko00000,ko04812 - - - AMMECR1,Memo YYD2_k127_2500501_8 745411.B3C1_04510 4.133e-19 91.0 COG5033@1|root,COG5033@2|Bacteria,1NBJM@1224|Proteobacteria,1SGE8@1236|Gammaproteobacteria 1236|Gammaproteobacteria K YEATS family - - - - - - - - - - - - YEATS YYD2_k127_2500501_2 1379698.RBG1_1C00001G0531 5.634e-65 234.0 COG0451@1|root,COG0451@2|Bacteria,2NPC7@2323|unclassified Bacteria 2|Bacteria GM NAD(P)H-binding JD73_00815 - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase YYD2_k127_2500501_0 1379698.RBG1_1C00001G0529 1.655e-104 353.0 COG0520@1|root,COG0520@2|Bacteria,2NP4B@2323|unclassified Bacteria 2|Bacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_5 YYD2_k127_2500501_7 452637.Oter_1617 4.101e-19 100.0 28IVM@1|root,2Z8U0@2|Bacteria,46S57@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - YYD2_k127_2500501_4 1173028.ANKO01000159_gene5219 1.316e-39 167.0 COG0642@1|root,COG2205@2|Bacteria,1G3AM@1117|Cyanobacteria,1HA0Y@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,cNMP_binding YYD2_k127_2500501_5 382464.ABSI01000006_gene764 2.84e-32 135.0 COG3794@1|root,COG3794@2|Bacteria,46SUG@74201|Verrucomicrobia,2IVQT@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Carboxypeptidase regulatory-like domain - - - - - - - - - - - - - YYD2_k127_2500501_6 1184267.A11Q_2332 2.065e-31 136.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2MUQI@213481|Bdellovibrionales,2WM7E@28221|Deltaproteobacteria 213481|Bdellovibrionales M PFAM NAD-dependent epimerase dehydratase dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - 3Beta_HSD,Epimerase YYD2_k127_2517901_0 1379698.RBG1_1C00001G0460 0.0 1300.0 COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria 2|Bacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon YYD2_k127_2517901_1 1124780.ANNU01000025_gene3419 5.296e-23 105.0 COG1331@1|root,COG1331@2|Bacteria,4PKPW@976|Bacteroidetes,47XYJ@768503|Cytophagia 976|Bacteroidetes O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7 YYD2_k127_2517901_2 517418.Ctha_0040 7.641e-22 102.0 COG0526@1|root,COG0526@2|Bacteria,1FE2F@1090|Chlorobi 1090|Chlorobi CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,Redoxin YYD2_k127_251857_1 518766.Rmar_2561 6.986e-75 267.0 COG1523@1|root,COG3291@1|root,COG1523@2|Bacteria,COG3291@2|Bacteria,4PKU5@976|Bacteroidetes,1FJYC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Pkd domain containing protein - - - - - - - - - - - - - YYD2_k127_251857_0 292415.Tbd_2287 9.314e-111 362.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VQQJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 YYD2_k127_251927_8 1336245.JAGO01000012_gene1854 6.534e-33 132.0 COG2885@1|root,COG2885@2|Bacteria,1RENP@1224|Proteobacteria,1S4IW@1236|Gammaproteobacteria,1XJ8G@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the ompA family oprF - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 YYD2_k127_251927_9 533247.CRD_01203 1.007e-26 112.0 COG0724@1|root,COG0724@2|Bacteria,1G7Q7@1117|Cyanobacteria,1HP3U@1161|Nostocales 1117|Cyanobacteria S RNA recognition motif - - - - - - - - - - - - RRM_1 YYD2_k127_251927_7 237368.SCABRO_01729 6.121e-42 164.0 COG0518@1|root,COG0518@2|Bacteria,2J0QU@203682|Planctomycetes 203682|Planctomycetes F Glutamine amidotransferase class-I - - - - - - - - - - - - GATase YYD2_k127_251927_3 643648.Slip_1551 2.182e-109 362.0 COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,42KBI@68298|Syntrophomonadaceae 186801|Clostridia H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth YYD2_k127_251927_4 998088.B565_2942 5.509e-87 301.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria,1Y3PQ@135624|Aeromonadales 135624|Aeromonadales E Belongs to the Orn Lys Arg decarboxylase class-II family - - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC YYD2_k127_251927_6 1150474.JQJI01000023_gene777 2.819e-42 159.0 COG1586@1|root,COG1586@2|Bacteria,2GCWX@200918|Thermotogae 200918|Thermotogae F Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc YYD2_k127_251927_5 404380.Gbem_2919 1.351e-52 191.0 COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1RCYA@1224|Proteobacteria,42QGN@68525|delta/epsilon subdivisions,2WIZH@28221|Deltaproteobacteria 28221|Deltaproteobacteria K transcriptional regulator - - - - - - - - - - - - Cupin_2,HTH_19,HTH_3 YYD2_k127_251927_2 330214.NIDE2727 5.306e-122 406.0 COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae 40117|Nitrospirae C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim YYD2_k127_251927_10 448385.sce1184 2.879e-05 58.0 COG1520@1|root,COG2931@1|root,COG4786@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,COG4786@2|Bacteria 2|Bacteria N Flagellar basal body rod flgK - 3.4.24.40 ko:K01406,ko:K02396,ko:K20276 ko01503,ko02024,ko02040,map01503,map02024,map02040 - - - ko00000,ko00001,ko01000,ko01002,ko02035 - - - DUF2950,Flg_bb_rod,Flg_bbr_C YYD2_k127_251927_1 1279017.AQYJ01000028_gene2405 1.187e-159 522.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,466B9@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 YYD2_k127_251927_0 761193.Runsl_1910 0.0 1064.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,47N7Y@768503|Cytophagia 976|Bacteroidetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 YYD2_k127_253405_0 1444309.JAQG01000116_gene3114 4.099e-67 235.0 COG1108@1|root,COG1108@2|Bacteria,1TPZB@1239|Firmicutes,4HBD7@91061|Bacilli,26QRV@186822|Paenibacillaceae 91061|Bacilli P ABC transporter mntC - - ko:K11709,ko:K19976 ko02010,map02010 M00319,M00792 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.15 - - ABC-3 YYD2_k127_253405_2 706587.Desti_4846 4.368e-23 111.0 2DRBJ@1|root,32UQT@2|Bacteria,1NZ28@1224|Proteobacteria,430B9@68525|delta/epsilon subdivisions,2WVZQ@28221|Deltaproteobacteria,2MRY8@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_253405_1 945713.IALB_0188 3.165e-25 120.0 COG1649@1|root,COG4733@1|root,COG1649@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity J - 3.2.1.11,3.2.1.18,3.2.1.35 ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K21449 ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142 M00076,M00077 R04018,R07824,R07825,R10905,R11309 RC00028,RC00077 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02000,ko02042 1.B.40.2 GH33,GH66 - DUF1983,DUF3672,Phage-tail_3 YYD2_k127_2659091_3 1122621.ATZA01000020_gene3999 3.923e-06 56.0 COG0438@1|root,COG0438@2|Bacteria,4NFPA@976|Bacteroidetes,1IPP6@117747|Sphingobacteriia 976|Bacteroidetes M N-acetyl-alpha-D-glucosaminyl L-malate synthase bshA - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 YYD2_k127_2659091_2 880073.Calab_3071 7.213e-25 123.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,DUF11,Flg_new,SLH YYD2_k127_2659091_1 485913.Krac_8040 4.702e-28 127.0 COG2114@1|root,COG2114@2|Bacteria 2|Bacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - DA1-like,GAF,Guanylate_cyc,HAMP,PAS_4,PAS_9,Response_reg,dCache_1 YYD2_k127_2659091_0 981383.AEWH01000056_gene1197 1.218e-44 165.0 COG0454@1|root,COG0454@2|Bacteria,1V4MU@1239|Firmicutes,4HHSQ@91061|Bacilli 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 YYD2_k127_2701530_0 1379698.RBG1_1C00001G0584 2.697e-231 739.0 COG2373@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG3386@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.4.24.40 ko:K01406,ko:K14274,ko:K20276,ko:K21449 ko00040,ko01503,ko02024,map00040,map01503,map02024 - R02427 RC00713 ko00000,ko00001,ko01000,ko01002,ko02000 1.B.40.2 - - Calx-beta,DUF4347,He_PIG,Ice_nucleation,SGL YYD2_k127_2701530_2 1379698.RBG1_1C00001G0583 3.592e-90 329.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - - - - - - - - - - ASH,Cohesin,FlgD_ig,Peptidase_S74 YYD2_k127_2701530_1 1379698.RBG1_1C00001G0582 7.726e-111 389.0 COG2911@1|root,COG2911@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - - - - - - - - - - - ASH,Cohesin,FlgD_ig,Peptidase_S74 YYD2_k127_2701530_3 1379698.RBG1_1C00001G0581 3.248e-51 207.0 COG2911@1|root,COG2911@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - - - - - - - - - - - ASH,Cohesin,FlgD_ig,Peptidase_S74 YYD2_k127_2707704_1 1123252.ATZF01000005_gene3936 1.447e-99 336.0 COG3424@1|root,COG3424@2|Bacteria,1TPUK@1239|Firmicutes,4HBHH@91061|Bacilli,27B3Q@186824|Thermoactinomycetaceae 91061|Bacilli Q Chalcone and stilbene synthases, N-terminal domain bcsA - - ko:K16167 - - - - ko00000,ko01008 - - - Chal_sti_synt_C,Chal_sti_synt_N YYD2_k127_2707704_3 1131462.DCF50_p2216 9.925e-28 116.0 COG1917@1|root,COG1917@2|Bacteria,1VDBA@1239|Firmicutes,24NXM@186801|Clostridia,262NC@186807|Peptococcaceae 186801|Clostridia S AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 YYD2_k127_2707704_2 1247726.MIM_c18140 2.377e-47 184.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,3T295@506|Alcaligenaceae 28216|Betaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport YYD2_k127_2707704_4 1089544.KB912942_gene490 8.603e-15 80.0 COG3324@1|root,COG3324@2|Bacteria,2IRUY@201174|Actinobacteria,4E63A@85010|Pseudonocardiales 201174|Actinobacteria S PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase YYD2_k127_2707704_0 1382356.JQMP01000001_gene1276 3.953e-124 407.0 COG0451@1|root,COG0451@2|Bacteria,2G5PB@200795|Chloroflexi 200795|Chloroflexi M Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - Epimerase YYD2_k127_2707704_5 1396141.BATP01000057_gene3074 0.0009857 51.0 COG0265@1|root,COG0265@2|Bacteria,46XAI@74201|Verrucomicrobia,2IUH0@203494|Verrucomicrobiae 203494|Verrucomicrobiae O Trypsin - - - - - - - - - - - - PDZ_2,Trypsin_2 YYD2_k127_271443_0 926550.CLDAP_17420 1.225e-153 496.0 COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi 200795|Chloroflexi O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH YYD2_k127_271443_8 517418.Ctha_1221 9.834e-40 165.0 2ECQK@1|root,336N8@2|Bacteria,1FEWY@1090|Chlorobi 1090|Chlorobi S Capsule assembly protein Wzi - - - - - - - - - - - - Caps_assemb_Wzi YYD2_k127_271443_4 1232410.KI421421_gene3366 6.991e-89 312.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,43UQ6@69541|Desulfuromonadales 28221|Deltaproteobacteria M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 YYD2_k127_271443_10 273068.TTE2137 1.01e-16 92.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,42FUW@68295|Thermoanaerobacterales 186801|Clostridia E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_271443_3 316067.Geob_3002 8.635e-109 385.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42M62@68525|delta/epsilon subdivisions,2WJ83@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Polysaccharide export protein - - - - - - - - - - - - Poly_export,SLBB YYD2_k127_271443_6 1379698.RBG1_1C00001G0660 2.672e-58 221.0 COG2067@1|root,COG2067@2|Bacteria,2NPN1@2323|unclassified Bacteria 2|Bacteria I Membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X YYD2_k127_271443_9 1379698.RBG1_1C00001G0661 5.955e-23 112.0 COG0627@1|root,COG0627@2|Bacteria,2NQQ3@2323|unclassified Bacteria 2|Bacteria S Putative esterase - - - - - - - - - - - - Esterase YYD2_k127_271443_7 555088.DealDRAFT_1412 8.9e-42 163.0 COG2120@1|root,COG2120@2|Bacteria,1TUFP@1239|Firmicutes,25PKR@186801|Clostridia,42KY4@68298|Syntrophomonadaceae 186801|Clostridia S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L YYD2_k127_271443_12 118168.MC7420_4440 2.787e-12 71.0 COG2827@1|root,COG2827@2|Bacteria,1G9KB@1117|Cyanobacteria,1HFTH@1150|Oscillatoriales 1117|Cyanobacteria L GIY-YIG catalytic domain - - - - - - - - - - - - GIY-YIG YYD2_k127_271443_2 1379698.RBG1_1C00001G0102 3.665e-109 359.0 COG0005@1|root,COG0005@2|Bacteria,2NP5F@2323|unclassified Bacteria 2|Bacteria F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 YYD2_k127_271443_11 292459.STH892 9.39e-16 86.0 COG1051@1|root,COG1051@2|Bacteria 2|Bacteria F GDP-mannose mannosyl hydrolase activity - - 3.6.1.13,3.6.1.55,3.6.1.67 ko:K01515,ko:K03574,ko:K08310,ko:K19965 ko00230,ko00790,map00230,map00790 M00126 R01054,R04638 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - NUDIX YYD2_k127_271443_1 1379698.RBG1_1C00001G0715 9.606e-116 384.0 COG0006@1|root,COG0006@2|Bacteria 2|Bacteria E proline dipeptidase activity - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 YYD2_k127_2744321_13 1121920.AUAU01000006_gene301 1.76e-12 69.0 2BYAB@1|root,32R2Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_2744321_3 1379698.RBG1_1C00001G1125 3.217e-91 307.0 COG1692@1|root,COG1692@2|Bacteria,2NNW9@2323|unclassified Bacteria 2|Bacteria S YmdB-like protein ymdB GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 - ko:K02029,ko:K02030,ko:K09769 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - YmdB YYD2_k127_2744321_2 1307761.L21SP2_1854 1.647e-104 348.0 COG0190@1|root,COG0190@2|Bacteria,2J5PR@203691|Spirochaetes 203691|Spirochaetes F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C YYD2_k127_2744321_14 1379698.RBG1_1C00001G1335 5.109e-07 64.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - - YYD2_k127_2744321_5 1379698.RBG1_1C00001G1334 9.02e-87 310.0 COG2067@1|root,COG2067@2|Bacteria,2NQKU@2323|unclassified Bacteria 2|Bacteria I Tetratricopeptide repeat - - - - - - - - - - - - TPR_2 YYD2_k127_2744321_4 1379698.RBG1_1C00001G1333 1.831e-88 317.0 COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2NP51@2323|unclassified Bacteria 2|Bacteria KT Sigma factor PP2C-like phosphatases pkn5 - 2.7.11.1,3.1.3.3 ko:K04757,ko:K07315 - - - - ko00000,ko01000,ko01001,ko03021 - - - AAA_16,GAF,HAMP,HATPase_c_2,Pkinase,SpoIIE,dCache_1 YYD2_k127_2744321_9 1379698.RBG1_1C00001G1332 1.594e-44 171.0 COG1366@1|root,COG1366@2|Bacteria,2NR50@2323|unclassified Bacteria 2|Bacteria T Anti-sigma factor antagonist - - - ko:K04749,ko:K06378 - - - - ko00000,ko03021 - - - STAS,STAS_2 YYD2_k127_2744321_8 1379698.RBG1_1C00001G1329 2.979e-49 196.0 COG2199@1|root,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria 2|Bacteria T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GAF_2,GGDEF,PAS_4,PAS_9,PocR,Response_reg YYD2_k127_2744321_12 247490.KSU1_C0424 1.75e-19 100.0 COG1596@1|root,COG1596@2|Bacteria,2J1I5@203682|Planctomycetes 203682|Planctomycetes M SLBB domain - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB YYD2_k127_2744321_15 46234.ANA_C12709 8.725e-05 54.0 COG0457@1|root,COG0457@2|Bacteria,1G649@1117|Cyanobacteria,1HM2D@1161|Nostocales 1117|Cyanobacteria S PFAM Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_2,TPR_8 YYD2_k127_2744321_10 1487921.DP68_03665 2.907e-40 160.0 COG0489@1|root,COG0489@2|Bacteria,1TS4R@1239|Firmicutes,24B0Z@186801|Clostridia,36DN2@31979|Clostridiaceae 186801|Clostridia D Capsular exopolysaccharide family - - - - - - - - - - - - AAA_31,ParA YYD2_k127_2744321_6 1499967.BAYZ01000028_gene1230 7.148e-69 243.0 COG0726@1|root,COG0726@2|Bacteria,2NPFG@2323|unclassified Bacteria 2|Bacteria G Domain of unknown function (DUF3473) - - - - - - - - - - - - DUF3473,Polysacc_deac_1 YYD2_k127_2744321_7 1379698.RBG1_1C00001G1136 1.393e-53 203.0 COG2956@1|root,COG2956@2|Bacteria 2|Bacteria G lipopolysaccharide metabolic process ciaB - - ko:K07502,ko:K08309,ko:K19804,ko:K21572 - - - - ko00000,ko01000,ko01011,ko02000 8.A.46.1,8.A.46.3 GH23 - SusD-like_3,SusD_RagB,TPR_16,TPR_6,TPR_8 YYD2_k127_2744321_0 518766.Rmar_1542 2.347e-223 721.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,1FJ5H@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V YYD2_k127_2744321_1 1379698.RBG1_1C00001G1139 1.937e-126 426.0 COG0323@1|root,COG0323@2|Bacteria,2NNP7@2323|unclassified Bacteria 2|Bacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C YYD2_k127_2744321_11 1158292.JPOE01000002_gene1761 4.76e-35 140.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1KJN5@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT YYD2_k127_27467_15 1379698.RBG1_1C00001G0115 5.293e-48 178.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_27467_19 330214.NIDE2490 5.755e-32 132.0 29ZH8@1|root,30MGZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_27467_14 247490.KSU1_B0648 4.354e-50 189.0 28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD2_k127_27467_17 671143.DAMO_0351 1.446e-42 165.0 2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_27467_11 880073.Calab_1920 1.655e-62 224.0 COG1801@1|root,COG1801@2|Bacteria,2NPDU@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 YYD2_k127_27467_7 1047013.AQSP01000052_gene2600 4.504e-87 297.0 COG4152@1|root,COG4152@2|Bacteria,2NQE2@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4162) natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 YYD2_k127_27467_10 1047013.AQSP01000052_gene2599 8.008e-63 233.0 COG1668@1|root,COG1668@2|Bacteria,2NPCQ@2323|unclassified Bacteria 2|Bacteria CP ABC-2 family transporter protein natB - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 YYD2_k127_27467_16 1229485.AMYV01000087_gene2831 5.052e-43 169.0 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,1RQBF@1236|Gammaproteobacteria,1J62W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S11 family pbpG GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 YYD2_k127_27467_0 1379698.RBG1_1C00001G1165 5.095e-307 961.0 COG0495@1|root,COG0495@2|Bacteria,2NNQH@2323|unclassified Bacteria 2|Bacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 YYD2_k127_27467_21 880073.Calab_3545 2.199e-27 123.0 COG0726@1|root,COG0726@2|Bacteria,2NPY1@2323|unclassified Bacteria 2|Bacteria G Polysaccharide deacetylase icaB - - - - - - - - - - - Glyco_transf_4,Polysacc_deac_1 YYD2_k127_27467_5 1379698.RBG1_1C00001G1161 2.184e-123 412.0 COG0612@1|root,COG0612@2|Bacteria,2NNW3@2323|unclassified Bacteria 2|Bacteria S Belongs to the peptidase M16 family pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD2_k127_27467_1 1379698.RBG1_1C00001G1160 5.755e-270 847.0 COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria 2|Bacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 YYD2_k127_27467_20 1499967.BAYZ01000080_gene915 1.459e-31 125.0 COG0184@1|root,COG0184@2|Bacteria,2NPTZ@2323|unclassified Bacteria 2|Bacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 YYD2_k127_27467_8 1379698.RBG1_1C00001G1158 9.803e-66 235.0 COG0196@1|root,COG0196@2|Bacteria,2NPCV@2323|unclassified Bacteria 2|Bacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K07011,ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase YYD2_k127_27467_12 1382306.JNIM01000001_gene2748 2.142e-57 211.0 COG0130@1|root,COG0130@2|Bacteria,2G6F4@200795|Chloroflexi 200795|Chloroflexi J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C,TruB_C_2,TruB_N YYD2_k127_27467_9 1379698.RBG1_1C00001G1156 8.375e-65 237.0 COG0618@1|root,COG0618@2|Bacteria,2NPK0@2323|unclassified Bacteria 2|Bacteria S DHH family nrnA GO:0008150,GO:0040007 2.7.7.72,3.1.13.3,3.1.3.7 ko:K00974,ko:K06881 ko00920,ko01100,ko01120,ko03013,map00920,map01100,map01120,map03013 - R00188,R00508,R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03400 - - - DHH,DHHA1 YYD2_k127_27467_24 717605.Theco_2056 8.44e-21 98.0 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,26YF0@186822|Paenibacillaceae 91061|Bacilli J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA YYD2_k127_27467_2 1379698.RBG1_1C00001G1153 4.047e-229 733.0 COG0532@1|root,COG0532@2|Bacteria,2NNRG@2323|unclassified Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N YYD2_k127_27467_4 1379698.RBG1_1C00001G1152 5.393e-142 466.0 COG0195@1|root,COG0195@2|Bacteria,2NNV1@2323|unclassified Bacteria 2|Bacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 YYD2_k127_27467_23 1379698.RBG1_1C00001G1151 1.903e-21 99.0 COG0779@1|root,COG0779@2|Bacteria,2NPVA@2323|unclassified Bacteria 2|Bacteria S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C YYD2_k127_27467_3 1379698.RBG1_1C00001G1150 4.686e-200 638.0 COG0442@1|root,COG0442@2|Bacteria,2NNNH@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iJN678.proS,iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit YYD2_k127_27467_22 926551.KB900739_gene62 5.255e-26 123.0 2EGT8@1|root,33AJC@2|Bacteria,4NY9U@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_27467_25 439235.Dalk_0558 1.98e-17 89.0 2EDE2@1|root,337AD@2|Bacteria,1NA2N@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - YYD2_k127_27467_18 404589.Anae109_0401 1.199e-33 133.0 COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,43765@68525|delta/epsilon subdivisions,2X24N@28221|Deltaproteobacteria,2YW4N@29|Myxococcales 28221|Deltaproteobacteria H pterin-4-alpha-carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a YYD2_k127_27467_13 1379698.RBG1_1C00001G0669 4.687e-56 205.0 COG3064@1|root,COG3064@2|Bacteria 2|Bacteria M translation initiation factor activity - - - ko:K03699 - - - - ko00000,ko02042 - - - Peptidase_M56 YYD2_k127_27467_6 1379698.RBG1_1C00001G0881 1.108e-118 403.0 COG0860@1|root,COG0860@2|Bacteria,2NQ79@2323|unclassified Bacteria 2|Bacteria M Ami_3 amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,GHL10,SpoIID YYD2_k127_2765537_0 1379698.RBG1_1C00001G1339 1.811e-111 370.0 COG1297@1|root,COG1297@2|Bacteria,2NP0C@2323|unclassified Bacteria 2|Bacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT YYD2_k127_2765537_5 1379698.RBG1_1C00001G0373 3.043e-35 145.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_5,Cadherin_3,Cleaved_Adhesin,FlgD_ig,HemolysinCabind,Kelch_1,Kelch_4,OmpA_membrane YYD2_k127_2765537_3 682795.AciX8_2612 7.2e-51 190.0 COG0767@1|root,COG0767@2|Bacteria,3Y43S@57723|Acidobacteria,2JI8E@204432|Acidobacteriia 204432|Acidobacteriia Q Belongs to the MlaE permease family - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE YYD2_k127_2765537_2 1162668.LFE_1729 1.863e-62 224.0 COG1127@1|root,COG1127@2|Bacteria,3J12B@40117|Nitrospirae 40117|Nitrospirae Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran YYD2_k127_2765537_4 289376.THEYE_A0330 2.296e-36 150.0 COG1463@1|root,COG1463@2|Bacteria,3J164@40117|Nitrospirae 40117|Nitrospirae Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD YYD2_k127_2765537_7 1172188.KB911822_gene926 5.105e-25 109.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase YYD2_k127_2765537_8 1121897.AUGO01000017_gene1098 4.834e-17 87.0 COG2350@1|root,COG2350@2|Bacteria,4NR5W@976|Bacteroidetes,1I5PD@117743|Flavobacteriia,2NU9F@237|Flavobacterium 976|Bacteroidetes S Protein conserved in bacteria - - - - - - - - - - - - - YYD2_k127_2765537_10 1121381.JNIV01000106_gene1932 4.637e-07 59.0 COG2318@1|root,COG2318@2|Bacteria,1WMWY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Protein of unknown function (DUF664) - - - - - - - - - - - - DUF664 YYD2_k127_2765537_11 1382359.JIAL01000001_gene1945 4.737e-06 57.0 COG4319@1|root,COG4319@2|Bacteria,3Y4YW@57723|Acidobacteria,2JJHI@204432|Acidobacteriia 204432|Acidobacteriia S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 YYD2_k127_2765537_6 118173.KB235914_gene3815 2.33e-32 133.0 COG0693@1|root,COG0693@2|Bacteria,1G2VP@1117|Cyanobacteria,1H8JH@1150|Oscillatoriales 1117|Cyanobacteria S PFAM DJ-1 PfpI family - - 3.5.1.124 ko:K03152,ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI,DUF2383 YYD2_k127_2765537_1 1379698.RBG1_1C00001G1107 3.2e-71 256.0 COG1207@1|root,COG1207@2|Bacteria,2NQ8F@2323|unclassified Bacteria 2|Bacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_4 YYD2_k127_2765537_9 589865.DaAHT2_1705 2.313e-09 58.0 COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria,2MKY0@213118|Desulfobacterales 28221|Deltaproteobacteria C Galactose-1-phosphate uridyl transferase, N-terminal domain galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - DUF4921,GalP_UDP_tr_C,GalP_UDP_transf YYD2_k127_278179_4 1379698.RBG1_1C00001G0632 4.341e-09 57.0 COG1366@1|root,COG1366@2|Bacteria,2NRCS@2323|unclassified Bacteria 2|Bacteria T STAS domain rsbV - - ko:K04749 - - - - ko00000,ko03021 - - - STAS,STAS_2 YYD2_k127_278179_2 1379698.RBG1_1C00001G0633 1.826e-32 131.0 COG2172@1|root,COG2172@2|Bacteria,2NQ1S@2323|unclassified Bacteria 2|Bacteria T Anti-sigma regulatory factor (Ser Thr protein kinase) - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2,SpoIIE YYD2_k127_278179_0 1379698.RBG1_1C00001G1345 1.608e-49 201.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria 2|Bacteria KT COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - GAF,GAF_2,HATPase_c_2,SSF,SpoIIE YYD2_k127_278179_1 1379698.RBG1_1C00001G0634 2.798e-46 174.0 COG1051@1|root,COG1051@2|Bacteria,2NPZ5@2323|unclassified Bacteria 2|Bacteria F NUDIX domain - - - - - - - - - - - - NUDIX,Nudix_N_2 YYD2_k127_278179_3 1089550.ATTH01000001_gene2205 9.64e-15 88.0 COG4775@1|root,COG4775@2|Bacteria,4P624@976|Bacteroidetes,1FIN0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Surface antigen - - - - - - - - - - - - Bac_surface_Ag YYD2_k127_2813606_25 880072.Desac_2546 4.593e-19 89.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,42MGE@68525|delta/epsilon subdivisions,2WJC2@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind YYD2_k127_2813606_13 246194.CHY_0977 2.183e-57 203.0 COG1898@1|root,COG1898@2|Bacteria 2|Bacteria M dTDP-4-dehydrorhamnose 3,5-epimerase activity rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom YYD2_k127_2813606_12 598659.NAMH_1708 1.817e-60 214.0 COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,42QUT@68525|delta/epsilon subdivisions,2YNVS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 YYD2_k127_2813606_7 891968.Anamo_1233 1.635e-95 332.0 COG2244@1|root,COG2244@2|Bacteria 2|Bacteria S polysaccharide biosynthetic process rfbE - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C YYD2_k127_2813606_11 335659.S23_56550 4.137e-79 281.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2U0YF@28211|Alphaproteobacteria,3JV8T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Glycosyl transferase 4-like domain - - 2.4.1.346,3.2.1.8 ko:K01181,ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 YYD2_k127_2813606_29 234621.RER_42900 1.216e-05 57.0 COG3307@1|root,COG3307@2|Bacteria,2IBTB@201174|Actinobacteria,4FXKT@85025|Nocardiaceae 201174|Actinobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C YYD2_k127_2813606_9 1347342.BN863_35050 2.88e-88 305.0 COG0438@1|root,COG0438@2|Bacteria,4NJDH@976|Bacteroidetes,1IIW0@117743|Flavobacteriia 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 YYD2_k127_2813606_5 251221.35211027 2.806e-125 412.0 COG0438@1|root,COG0438@2|Bacteria,1G8EM@1117|Cyanobacteria 2|Bacteria M Domain of unknown function (DUF1972) rgpA - - ko:K12996 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - DUF1972,Glyco_trans_1_4,Glycos_transf_1 YYD2_k127_2813606_26 319225.Plut_1888 2.624e-15 88.0 COG3206@1|root,COG3206@2|Bacteria 2|Bacteria M extracellular polysaccharide biosynthetic process - - 3.1.21.3 ko:K01153,ko:K05789,ko:K07011,ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01005,ko02000,ko02048 8.A.3.1 - - GNVR,Wzz YYD2_k127_2813606_1 1519464.HY22_06785 1.375e-275 866.0 COG3808@1|root,COG3808@2|Bacteria,1FD6P@1090|Chlorobi 1090|Chlorobi C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase YYD2_k127_2813606_16 797303.Natpe_2206 6.625e-56 215.0 COG0534@1|root,arCOG01731@2157|Archaea,2XU54@28890|Euryarchaeota,23SKQ@183963|Halobacteria 183963|Halobacteria V COG0534 Na -driven multidrug efflux pump - - - - - - - - - - - - MatE YYD2_k127_2813606_15 1379698.RBG1_1C00001G1558 5.73e-57 205.0 COG1974@1|root,COG1974@2|Bacteria,2NPJG@2323|unclassified Bacteria 2|Bacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 YYD2_k127_2813606_0 1379698.RBG1_1C00001G1048 1.851e-310 967.0 COG1205@1|root,COG1205@2|Bacteria,2NNKJ@2323|unclassified Bacteria 2|Bacteria L Domain of unknown function (DUF1998) yprA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C YYD2_k127_2813606_17 1379698.RBG1_1C00001G1047 3.043e-49 181.0 COG1913@1|root,COG1913@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 YYD2_k127_2813606_27 344747.PM8797T_28824 1.189e-12 70.0 2EPX9@1|root,33HHS@2|Bacteria,2J4DJ@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD2_k127_2813606_18 1321784.HMPREF1987_01353 1.124e-45 174.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia 186801|Clostridia F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC YYD2_k127_2813606_4 1121468.AUBR01000002_gene642 1.87e-142 462.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,42F24@68295|Thermoanaerobacterales 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme YYD2_k127_2813606_30 189753.AXAS01000023_gene826 5.37e-05 52.0 COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,3JRXS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Putative zinc-finger - - - - - - - - - - - - zf-HC2 YYD2_k127_2813606_21 1121422.AUMW01000024_gene240 4.134e-30 128.0 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily algU - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD2_k127_2813606_10 246194.CHY_0588 8.839e-83 292.0 COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,42F15@68295|Thermoanaerobacterales 186801|Clostridia P PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr YYD2_k127_2813606_14 948106.AWZT01000001_gene5337 2.232e-57 212.0 COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,2VTKP@28216|Betaproteobacteria,1K3AS@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM OsmC family protein osmC - - ko:K04063 - - - - ko00000 - - - OsmC YYD2_k127_2813606_2 1379698.RBG1_1C00001G1403 9.11e-156 504.0 COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria 2|Bacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_2,GSDH YYD2_k127_2813606_20 1122925.KB895377_gene1481 1.727e-31 136.0 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,4H9RF@91061|Bacilli,26T0W@186822|Paenibacillaceae 91061|Bacilli L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon YYD2_k127_2813606_3 350688.Clos_1187 1.602e-152 497.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,36DCC@31979|Clostridiaceae 186801|Clostridia E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic YYD2_k127_2813606_8 1499967.BAYZ01000177_gene5744 3.89e-92 328.0 COG1368@1|root,COG1368@2|Bacteria,2NRZV@2323|unclassified Bacteria 2|Bacteria M Sulfatase - - - - - - - - - - - - Sulfatase YYD2_k127_2813606_19 1480694.DC28_03280 7.944e-36 138.0 COG0393@1|root,COG0393@2|Bacteria 2|Bacteria S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 YYD2_k127_2813606_22 880073.Calab_0082 1.584e-29 125.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD2_k127_2813606_6 1121920.AUAU01000004_gene672 1.048e-105 354.0 COG3342@1|root,COG3342@2|Bacteria,3Y80E@57723|Acidobacteria 57723|Acidobacteria S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028 YYD2_k127_2813606_24 929562.Emtol_2945 2.634e-22 99.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,4NFZR@976|Bacteroidetes,47N0I@768503|Cytophagia 976|Bacteroidetes M PFAM peptidase M28 - - - - - - - - - - - - PD40,PDZ_2,Peptidase_M28 YYD2_k127_28319_7 1379698.RBG1_1C00001G0668 3.481e-33 143.0 COG2885@1|root,COG5276@1|root,COG2885@2|Bacteria,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - 3.4.24.40 ko:K01406,ko:K21449 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002,ko02000 1.B.40.2 - - DUF1566,Phenol_MetA_deg YYD2_k127_28319_5 204669.Acid345_2109 6.939e-49 190.0 COG5295@1|root,COG5295@2|Bacteria,3Y72W@57723|Acidobacteria,2JM9T@204432|Acidobacteriia 2|Bacteria UW Hep Hag repeat protein yeeJ - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF5122,Peptidase_S74,YadA_head,YadA_stalk YYD2_k127_28319_11 1379698.RBG1_1C00001G0282 4.977e-16 91.0 COG5276@1|root,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,LVIVD YYD2_k127_28319_12 1267534.KB906757_gene857 3.318e-15 87.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - DUF4347,Lactonase,Laminin_G_3,VCBS,VPEP YYD2_k127_28319_9 926569.ANT_31340 2.101e-29 126.0 COG0724@1|root,COG0724@2|Bacteria,2G74A@200795|Chloroflexi 200795|Chloroflexi S PFAM RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 YYD2_k127_28319_8 243090.RB10458 2.352e-30 123.0 COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes 203682|Planctomycetes S PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - - - - - - - - - - RRM_1 YYD2_k127_28319_15 1296415.JACC01000006_gene1419 7.573e-07 63.0 COG4206@1|root,COG4206@2|Bacteria,4NE1W@976|Bacteroidetes,1HXSU@117743|Flavobacteriia,2YHHH@290174|Aquimarina 976|Bacteroidetes H Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD2_k127_28319_4 926569.ANT_07880 5.255e-58 213.0 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination - - - ko:K03298 - - - - ko00000,ko02000 2.A.7.3 - - EamA YYD2_k127_28319_16 234267.Acid_7282 7.966e-07 61.0 2CEM8@1|root,344D4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_28319_10 1379698.RBG1_1C00001G0552 5.736e-17 87.0 COG1544@1|root,COG1544@2|Bacteria 2|Bacteria J regulation of translation hpf GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006446,GO:0006448,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808,ko:K05809 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE YYD2_k127_28319_0 1379698.RBG1_1C00001G0551 5.13e-153 497.0 COG1508@1|root,COG1508@2|Bacteria,2NNZA@2323|unclassified Bacteria 2|Bacteria K RNA polymerase sigma-54 factor rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD YYD2_k127_28319_2 1379698.RBG1_1C00001G0549 3.898e-103 340.0 COG1137@1|root,COG1137@2|Bacteria,2NNRT@2323|unclassified Bacteria 2|Bacteria S lipopolysaccharide transport protein B ATP-binding component of ABC superfamily lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K01990,ko:K06861 ko02010,map02010 M00254,M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1,3.A.1 - - ABC_tran,BCA_ABC_TP_C YYD2_k127_28319_17 667014.Thein_0899 5.983e-05 56.0 COG0457@1|root,COG0457@2|Bacteria,2GHED@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S ChAPs (Chs5p-Arf1p-binding proteins) - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 YYD2_k127_28319_1 933262.AXAM01000070_gene2280 1e-125 410.0 COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,43BNE@68525|delta/epsilon subdivisions,2WKIX@28221|Deltaproteobacteria,2MJ8D@213118|Desulfobacterales 28221|Deltaproteobacteria M NmrA-like family - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd YYD2_k127_28319_3 448385.sce4782 2.13e-73 254.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2WJEC@28221|Deltaproteobacteria,2Z2Y8@29|Myxococcales 28221|Deltaproteobacteria JM Nucleotidyl transferase - - - - - - - - - - - - CBS,NTP_transferase YYD2_k127_28319_6 1047013.AQSP01000134_gene1374 8.252e-45 175.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux YYD2_k127_2838737_6 330214.NIDE2676 3.25e-25 109.0 COG4095@1|root,COG4095@2|Bacteria,3J0UA@40117|Nitrospirae 40117|Nitrospirae S PQ loop repeat - - - ko:K15383 - - - - ko00000,ko02000 9.A.58.2 - - PQ-loop YYD2_k127_2838737_2 1379698.RBG1_1C00001G0462 6.016e-75 262.0 COG2067@1|root,COG2067@2|Bacteria,2NPVZ@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - YYD2_k127_2838737_7 1051985.l11_07360 5.434e-07 60.0 COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,2VXV9@28216|Betaproteobacteria,2KSB6@206351|Neisseriales 206351|Neisseriales C Heavy metal-associated domain protein - - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA YYD2_k127_2838737_5 1267211.KI669560_gene110 1.466e-33 134.0 COG0640@1|root,COG0640@2|Bacteria,4NQK3@976|Bacteroidetes,1ITK5@117747|Sphingobacteriia 976|Bacteroidetes K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 YYD2_k127_2838737_1 929556.Solca_3634 5.379e-86 291.0 COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,1IP66@117747|Sphingobacteriia 976|Bacteroidetes Q Methylase involved in ubiquinone menaquinone biosynthesis arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 YYD2_k127_2838737_0 357808.RoseRS_1917 8.99e-178 562.0 COG0798@1|root,COG0798@2|Bacteria,2G5ZH@200795|Chloroflexi,37708@32061|Chloroflexia 32061|Chloroflexia P Sodium Bile acid symporter family - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF YYD2_k127_2838737_3 743722.Sph21_0232 8.83e-43 160.0 COG0394@1|root,COG0394@2|Bacteria,4NNN6@976|Bacteroidetes,1IS9S@117747|Sphingobacteriia 976|Bacteroidetes T Low molecular weight phosphotyrosine protein phosphatase arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc YYD2_k127_2838737_4 573061.Clocel_3666 3.306e-34 136.0 COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,36DDQ@31979|Clostridiaceae 186801|Clostridia C PFAM Radical SAM domain protein - - - ko:K22226 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM YYD2_k127_2851433_12 1158146.KB907121_gene1092 0.0004421 53.0 COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,1S4SH@1236|Gammaproteobacteria,1WZF6@135613|Chromatiales 135613|Chromatiales MU Outer membrane efflux protein - - - - - - - - - - - - OEP YYD2_k127_2851433_11 1134510.O9A_00247 0.0001464 55.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,48TB8@772|Bartonellaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind YYD2_k127_2851433_9 1101191.KI912577_gene2342 1.139e-17 87.0 COG0784@1|root,COG3920@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG3920@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JQUH@119045|Methylobacteriaceae 28211|Alphaproteobacteria T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,dCache_1 YYD2_k127_2851433_2 1128421.JAGA01000002_gene1856 7.37e-121 410.0 COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria 2|Bacteria V ABC transporter MdlB - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran YYD2_k127_2851433_5 485918.Cpin_5496 1.081e-98 344.0 COG1132@1|root,COG1132@2|Bacteria,4NDY6@976|Bacteroidetes,1IPDM@117747|Sphingobacteriia 976|Bacteroidetes V ABC transporter mdlA - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran YYD2_k127_2851433_4 243231.GSU2357 5.145e-99 336.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel YYD2_k127_2851433_3 1047013.AQSP01000110_gene67 9.801e-117 385.0 COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria 2|Bacteria P CorA-like Mg2+ transporter protein corA GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA YYD2_k127_2851433_1 1094980.Mpsy_2655 1.985e-127 419.0 COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia 224756|Methanomicrobia P Citrate transporter - - - - - - - - - - - - CitMHS YYD2_k127_2851433_7 671143.DAMO_0437 6.617e-23 104.0 2EBKA@1|root,335KQ@2|Bacteria,2NRDT@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_2851433_0 195250.CM001776_gene1952 9.169e-143 463.0 COG2223@1|root,COG2223@2|Bacteria 2|Bacteria P nitrite transmembrane transporter activity - - - - - - - - - - - - MFS_1 YYD2_k127_2851433_10 755731.Clo1100_1900 3.266e-05 55.0 COG3325@1|root,COG3325@2|Bacteria,1UPJ7@1239|Firmicutes,24D95@186801|Clostridia,36EAZ@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 18 family - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - 1-cysPrx_C,AhpC-TSA,Dockerin_1,Glyco_hydro_18 YYD2_k127_2851433_8 1191523.MROS_0520 1.58e-21 113.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - Porin_2 YYD2_k127_2851433_6 926562.Oweho_1851 7.266e-49 203.0 COG3420@1|root,COG3420@2|Bacteria,4PPAE@976|Bacteroidetes,1IKH4@117743|Flavobacteriia,2PBVP@246874|Cryomorphaceae 2|Bacteria P alginic acid biosynthetic process - - - - - - - - - - - - Beta_helix YYD2_k127_2852087_0 1379698.RBG1_1C00001G1395 1.733e-69 244.0 28IS3@1|root,2Z8R9@2|Bacteria 2|Bacteria S Psort location Cytoplasmic, score - - - - - - - - - - - - Phage_capsid YYD2_k127_2869413_0 1173028.ANKO01000057_gene6232 2.216e-49 187.0 COG0664@1|root,COG0664@2|Bacteria,1G3SU@1117|Cyanobacteria,1H8VY@1150|Oscillatoriales 1117|Cyanobacteria K Cyclic nucleotide-binding domain - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding YYD2_k127_2869413_2 880073.Calab_0041 1.053e-24 119.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase YYD2_k127_2869413_1 1379698.RBG1_1C00001G0098 9.912e-32 128.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - Response_reg YYD2_k127_2869413_3 1122217.KB899566_gene499 0.0001318 46.0 COG0486@1|root,COG0486@2|Bacteria,1TQA8@1239|Firmicutes,4H28K@909932|Negativicutes 909932|Negativicutes S maturation GTPase HydF hydF - - - - - - - - - - - MMR_HSR1 YYD2_k127_2870232_0 387631.Asulf_00513 1.536e-35 143.0 COG0346@1|root,arCOG02706@2157|Archaea,2XY0R@28890|Euryarchaeota,2469B@183980|Archaeoglobi 183980|Archaeoglobi E Glyoxalase-like domain - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 YYD2_k127_2870232_1 443254.Marpi_1856 3.311e-21 95.0 COG1884@1|root,COG1884@2|Bacteria,2GBZM@200918|Thermotogae 200918|Thermotogae I PFAM Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase YYD2_k127_2949928_25 1379698.RBG1_1C00001G0462 7.843e-12 67.0 COG2067@1|root,COG2067@2|Bacteria,2NPVZ@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - YYD2_k127_2949928_22 330214.NIDE2676 1.132e-25 110.0 COG4095@1|root,COG4095@2|Bacteria,3J0UA@40117|Nitrospirae 40117|Nitrospirae S PQ loop repeat - - - ko:K15383 - - - - ko00000,ko02000 9.A.58.2 - - PQ-loop YYD2_k127_2949928_2 323261.Noc_1458 4.504e-166 528.0 COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria,1SYTE@1236|Gammaproteobacteria,1X0JZ@135613|Chromatiales 135613|Chromatiales U beta Propeller - - - - - - - - - - - - PD40 YYD2_k127_2949928_12 1379698.RBG1_1C00001G0346 2.297e-91 310.0 COG0341@1|root,COG0341@2|Bacteria,2NP4P@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG YYD2_k127_2949928_11 880073.Calab_0027 1.811e-98 342.0 COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG YYD2_k127_2949928_6 237368.SCABRO_03474 8.257e-114 400.0 COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes 203682|Planctomycetes S PFAM Peptidase M16 inactive domain - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C YYD2_k127_2949928_7 479434.Sthe_2452 7.554e-104 351.0 COG0530@1|root,COG0530@2|Bacteria 2|Bacteria P calcium, potassium:sodium antiporter activity - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex YYD2_k127_2949928_17 665571.STHERM_c07970 5.178e-40 160.0 COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system ptsN_1 - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - CBS,HTH_17,PTS_EIIA_2 YYD2_k127_2949928_16 1379698.RBG1_1C00001G0360 2.158e-44 169.0 COG2928@1|root,COG2928@2|Bacteria,2NR55@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 YYD2_k127_2949928_8 1121468.AUBR01000050_gene2028 1.343e-102 351.0 COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia,42FCA@68295|Thermoanaerobacterales 186801|Clostridia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M YYD2_k127_2949928_3 880073.Calab_2684 1.005e-161 523.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM2 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M YYD2_k127_2949928_1 246194.CHY_1417 3.378e-167 548.0 COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia,42FX8@68295|Thermoanaerobacterales 186801|Clostridia C NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus ndhF - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N YYD2_k127_2949928_20 671143.DAMO_2707 7.774e-30 123.0 COG0713@1|root,COG0713@2|Bacteria,2NQ6R@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 YYD2_k127_2949928_23 867845.KI911784_gene1875 1.953e-25 112.0 COG0839@1|root,COG0839@2|Bacteria,2G777@200795|Chloroflexi,375K1@32061|Chloroflexia 32061|Chloroflexia C Belongs to the complex I subunit 6 family - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 YYD2_k127_2949928_24 1121403.AUCV01000012_gene4037 2e-25 113.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42SZV@68525|delta/epsilon subdivisions,2WP8T@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338,ko:K05580 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_4,Fer4_7 YYD2_k127_2949928_10 880072.Desac_1204 2.334e-100 340.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MQ5S@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh YYD2_k127_2949928_5 1123511.KB905842_gene1665 1.235e-131 429.0 COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,4H2Z2@909932|Negativicutes 909932|Negativicutes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa YYD2_k127_2949928_21 1131269.AQVV01000025_gene2341 8.606e-27 115.0 COG0852@1|root,COG0852@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa YYD2_k127_2949928_15 1279009.ADICEAN_01551 3.126e-62 219.0 COG0377@1|root,COG0377@2|Bacteria,4NFKT@976|Bacteroidetes,47JYD@768503|Cytophagia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 YYD2_k127_2949928_19 986075.CathTA2_2804 8.765e-38 145.0 COG0838@1|root,COG0838@2|Bacteria,1V6P3@1239|Firmicutes,4HIFX@91061|Bacilli 91061|Bacilli C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 YYD2_k127_2949928_18 1121403.AUCV01000039_gene4348 1.255e-39 151.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria,2MKP9@213118|Desulfobacterales 28221|Deltaproteobacteria J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP YYD2_k127_2949928_27 679197.HMPREF9336_01244 2.372e-09 63.0 COG2259@1|root,COG2259@2|Bacteria,2HC2E@201174|Actinobacteria 201174|Actinobacteria S DoxX - - 1.8.5.2 ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxX YYD2_k127_2949928_14 237368.SCABRO_00983 2.014e-68 246.0 COG2206@1|root,COG2206@2|Bacteria,2J3D3@203682|Planctomycetes 203682|Planctomycetes T signal transduction HD GYP protein - - - - - - - - - - - - HD,HD_5 YYD2_k127_2949928_4 1379698.RBG1_1C00001G1660 2.221e-133 435.0 COG4867@1|root,COG4867@2|Bacteria,2NQZ8@2323|unclassified Bacteria 2|Bacteria S von Willebrand factor (vWF) type A domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA_2 YYD2_k127_2949928_0 1379698.RBG1_1C00001G1661 4.765e-179 573.0 COG1239@1|root,COG1239@2|Bacteria,2NQQG@2323|unclassified Bacteria 2|Bacteria H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX chlI - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - iNJ661.Rv0958 Mg_chelatase,Sigma54_activat YYD2_k127_2949928_26 575605.ACQN01000026_gene849 1.104e-11 68.0 COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,4HKJJ@91061|Bacilli,3F7JX@33958|Lactobacillaceae 91061|Bacilli J S4 domain protein yabO - - - - - - - - - - - S4 YYD2_k127_2949928_9 1379698.RBG1_1C00001G0705 5.499e-101 345.0 COG0760@1|root,COG0760@2|Bacteria,2NPFB@2323|unclassified Bacteria 2|Bacteria O PPIC-type PPIASE domain surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N_3 YYD2_k127_2980223_2 929556.Solca_2812 0.0007259 45.0 COG0373@1|root,COG0373@2|Bacteria,4NFTY@976|Bacteroidetes,1IQ3B@117747|Sphingobacteriia 976|Bacteroidetes H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH YYD2_k127_2980223_0 349741.Amuc_1222 4.239e-206 660.0 COG1297@1|root,COG1297@2|Bacteria,46TNW@74201|Verrucomicrobia,2IV9P@203494|Verrucomicrobiae 203494|Verrucomicrobiae S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT YYD2_k127_2980223_1 1122939.ATUD01000002_gene1305 1.16e-41 160.0 COG3000@1|root,COG3000@2|Bacteria,2ISSM@201174|Actinobacteria,4CQ11@84995|Rubrobacteria 84995|Rubrobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase YYD2_k127_2989619_2 684949.ATTJ01000001_gene623 8.282e-09 57.0 COG3424@1|root,COG3424@2|Bacteria,1WKVP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q PFAM Chalcone and stilbene synthases, N-terminal domain - - - ko:K16167 - - - - ko00000,ko01008 - - - Chal_sti_synt_C,Chal_sti_synt_N YYD2_k127_2989619_0 391615.ABSJ01000005_gene583 2.428e-63 227.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1J4DJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P YYD2_k127_2989619_1 1216007.AOPM01000058_gene1893 2.936e-10 66.0 COG3011@1|root,COG3011@2|Bacteria,1N08P@1224|Proteobacteria,1S8S3@1236|Gammaproteobacteria,2Q2JB@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF393 YYD2_k127_2989619_3 202954.BBNK01000005_gene1707 5.534e-06 57.0 COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S5A7@1236|Gammaproteobacteria,3NT4J@468|Moraxellaceae 1236|Gammaproteobacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C YYD2_k127_3053625_1 1379698.RBG1_1C00001G1633 1.438e-208 657.0 COG0423@1|root,COG0423@2|Bacteria,2NNN9@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSB619.SA_RS07880 HGTP_anticodon,tRNA-synt_2b YYD2_k127_3053625_5 373903.Hore_12480 6.487e-17 91.0 COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,3WAT7@53433|Halanaerobiales 186801|Clostridia L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N YYD2_k127_3053625_0 187272.Mlg_2286 1.127e-246 784.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C YYD2_k127_3053625_3 273068.TTE0628 5.347e-51 189.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,42GDM@68295|Thermoanaerobacterales 186801|Clostridia D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 YYD2_k127_3053625_2 760142.Hipma_1670 7.772e-144 467.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2M6Y2@213113|Desulfurellales 28221|Deltaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt YYD2_k127_3053625_4 272558.10174800 3.502e-22 106.0 COG2162@1|root,COG2162@2|Bacteria,1VA4Y@1239|Firmicutes,4HKYP@91061|Bacilli,1ZGW6@1386|Bacillus 91061|Bacilli Q N-acetyltransferase - - - - - - - - - - - - Acetyltransf_2 YYD2_k127_3134081_0 1168034.FH5T_18240 1.128e-145 472.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,2FMBN@200643|Bacteroidia 976|Bacteroidetes I Biotin carboxylase accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 YYD2_k127_3134081_1 1128421.JAGA01000002_gene1141 1.531e-74 260.0 COG1024@1|root,COG1024@2|Bacteria,2NR3A@2323|unclassified Bacteria 2|Bacteria I Enoyl-CoA hydratase/isomerase atuE - 4.2.1.18,4.2.1.57 ko:K13766,ko:K13779 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R02085,R03493 RC00941,RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 YYD2_k127_3134081_2 1382306.JNIM01000001_gene2570 8.948e-62 215.0 COG4799@1|root,COG4799@2|Bacteria,2G61R@200795|Chloroflexi 200795|Chloroflexi I PFAM carboxyl transferase - - 2.1.3.15,6.4.1.3,6.4.1.4 ko:K01969,ko:K15052 ko00280,ko00720,ko01100,ko01200,map00280,map00720,map01100,map01200 M00036,M00376 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans YYD2_k127_3136663_2 935948.KE386494_gene517 6.938e-28 115.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran YYD2_k127_3136663_0 926550.CLDAP_23690 3.028e-32 130.0 COG1765@1|root,COG1765@2|Bacteria,2G6Y1@200795|Chloroflexi 200795|Chloroflexi O PFAM OsmC family protein - - - ko:K07397 - - - - ko00000 - - - OsmC YYD2_k127_3136663_1 768706.Desor_5062 3.06e-32 129.0 COG3439@1|root,COG3439@2|Bacteria,1VA5R@1239|Firmicutes,24NQI@186801|Clostridia 186801|Clostridia S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 YYD2_k127_3136663_3 309799.DICTH_1607 7.276e-11 64.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 YYD2_k127_313800_2 579137.Metvu_0562 1.43e-28 130.0 COG5410@1|root,arCOG09550@2157|Archaea,2XW1V@28890|Euryarchaeota,23QCA@183939|Methanococci 183939|Methanococci S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C YYD2_k127_313800_3 880073.Calab_0041 7.528e-25 122.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase YYD2_k127_313800_4 401053.AciPR4_3151 3.163e-13 83.0 COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria,2JHKF@204432|Acidobacteriia 204432|Acidobacteriia C Putative adhesin - - - - - - - - - - - - DUF4097 YYD2_k127_313800_1 643648.Slip_1776 2.08e-36 154.0 COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,42KAI@68298|Syntrophomonadaceae 186801|Clostridia T HDOD domain - - - - - - - - - - - - HDOD,Response_reg YYD2_k127_313800_5 1122917.KB899660_gene1435 0.0007031 47.0 COG0457@1|root,COG3359@1|root,COG0457@2|Bacteria,COG3359@2|Bacteria,1TQQU@1239|Firmicutes,4HDMU@91061|Bacilli,26TUQ@186822|Paenibacillaceae 91061|Bacilli L RNase_H superfamily yprB - - ko:K07502 - - - - ko00000 - - - RNase_H_2 YYD2_k127_3142977_6 573370.DMR_17720 1.128e-23 101.0 COG3585@1|root,COG3585@2|Bacteria,1P6UA@1224|Proteobacteria,432HS@68525|delta/epsilon subdivisions,2WXFT@28221|Deltaproteobacteria,2MFR4@213115|Desulfovibrionales 28221|Deltaproteobacteria H TOBE domain - - - - - - - - - - - - TOBE YYD2_k127_3142977_2 945713.IALB_1750 3.059e-119 415.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD2_k127_3142977_3 1303518.CCALI_00380 1.077e-99 341.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF YYD2_k127_3142977_4 1336803.PHEL49_2600 4.064e-34 136.0 COG0782@1|root,COG0782@2|Bacteria,4NNH6@976|Bacteroidetes,1I18I@117743|Flavobacteriia,3VW7V@52959|Polaribacter 976|Bacteroidetes K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N YYD2_k127_3142977_0 1379698.RBG1_1C00001G1698 4.987e-129 420.0 COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria 2|Bacteria E Pyridoxal-phosphate dependent enzyme cysK - 2.5.1.47,4.2.1.22 ko:K01697,ko:K01738 ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00035,M00338 R00891,R00897,R01290,R03601,R04859,R04942 RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP YYD2_k127_3142977_1 1379698.RBG1_1C00001G1697 1.438e-128 422.0 COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria 2|Bacteria E Cys/Met metabolism PLP-dependent enzyme metC GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 ko:K01739,ko:K01758,ko:K01760,ko:K01761 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP YYD2_k127_3142977_5 1101191.KI912577_gene2022 8.282e-33 129.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2U249@28211|Alphaproteobacteria,1JUUW@119045|Methylobacteriaceae 28211|Alphaproteobacteria O peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N,Rhodanese YYD2_k127_3149496_4 326427.Cagg_2140 1.708e-80 278.0 COG0524@1|root,COG0524@2|Bacteria,2GAA6@200795|Chloroflexi,376QU@32061|Chloroflexia 32061|Chloroflexia G PFAM PfkB domain protein - - - - - - - - - - - - PfkB YYD2_k127_3149496_1 211165.AJLN01000100_gene4293 3.537e-190 604.0 arCOG06766@1|root,2Z87F@2|Bacteria,1G1NX@1117|Cyanobacteria,1JKSG@1189|Stigonemataceae 1117|Cyanobacteria - - - - - - - - - - - - - - - YYD2_k127_3149496_14 384765.SIAM614_20910 5.303e-37 142.0 COG0073@1|root,COG0073@2|Bacteria,1RGU7@1224|Proteobacteria,2U9AH@28211|Alphaproteobacteria 28211|Alphaproteobacteria J COG0073 EMAP domain csaA - - ko:K06878 - - - - ko00000 - - - tRNA_bind YYD2_k127_3149496_15 1265505.ATUG01000002_gene974 1.4e-29 127.0 COG1102@1|root,COG1102@2|Bacteria,1RCTZ@1224|Proteobacteria,42R0B@68525|delta/epsilon subdivisions,2WMVD@28221|Deltaproteobacteria,2MJH5@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 YYD2_k127_3149496_8 1007103.AFHW01000001_gene4886 4.609e-57 208.0 COG2227@1|root,COG2227@2|Bacteria,1VAV7@1239|Firmicutes,4HPRU@91061|Bacilli,277FW@186822|Paenibacillaceae 91061|Bacilli H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 YYD2_k127_3149496_10 1379698.RBG1_1C00001G1857 2.623e-55 207.0 COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ YYD2_k127_3149496_2 1379698.RBG1_1C00001G1858 2.746e-108 365.0 COG0795@1|root,COG0795@2|Bacteria,2NP9S@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ family protein lptF GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K07091,ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - iECED1_1282.ECED1_5114,iUMNK88_1353.UMNK88_5207 YjgP_YjgQ YYD2_k127_3149496_7 1191523.MROS_0556 1.557e-58 216.0 COG3481@1|root,COG3481@2|Bacteria 2|Bacteria D metal-dependent phosphohydrolase, HD sub domain yhaM - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,tRNA_anti-codon YYD2_k127_3149496_12 558169.AGAV01000005_gene2214 5.397e-46 170.0 COG0346@1|root,COG0346@2|Bacteria,1V48E@1239|Firmicutes,4HHUT@91061|Bacilli 91061|Bacilli E COG0346 Lactoylglutathione lyase and related lyases yurT - - - - - - - - - - - Glyoxalase YYD2_k127_3149496_20 903818.KI912268_gene1852 2.561e-10 66.0 COG2203@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3852@2|Bacteria,3Y9EC@57723|Acidobacteria 2|Bacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg YYD2_k127_3149496_19 1123020.AUIE01000002_gene1564 6.301e-17 96.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RQIN@1236|Gammaproteobacteria,1YEEY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain dctB - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 YYD2_k127_3149496_11 1500301.JQMF01000024_gene2043 1.951e-50 185.0 COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,2VG87@28211|Alphaproteobacteria,4BNHK@82115|Rhizobiaceae 28211|Alphaproteobacteria S Flavodoxin-like fold - - - - - - - - - - - - FMN_red YYD2_k127_3149496_16 1121352.JHZP01000001_gene551 1.025e-28 125.0 COG2849@1|root,COG2849@2|Bacteria,1RJZH@1224|Proteobacteria,2VT1T@28216|Betaproteobacteria,2KRHY@206351|Neisseriales 206351|Neisseriales S MORN repeat protein - - - - - - - - - - - - MORN_2 YYD2_k127_3149496_18 667014.Thein_1751 3.225e-25 117.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 YYD2_k127_3149496_3 269799.Gmet_0754 2.616e-99 338.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,43UZT@69541|Desulfuromonadales 28221|Deltaproteobacteria S SPFH domain-Band 7 family - - - - - - - - - - - - Band_7_1,DUF4339,DZR,SHOCT,zinc_ribbon_2 YYD2_k127_3149496_21 1167006.UWK_02302 0.0002856 53.0 COG1996@1|root,COG1996@2|Bacteria,1R71V@1224|Proteobacteria,42PRX@68525|delta/epsilon subdivisions,2WMQY@28221|Deltaproteobacteria,2MIG3@213118|Desulfobacterales 28221|Deltaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - YYD2_k127_3149496_13 1382304.JNIL01000001_gene2641 1.747e-44 165.0 COG0454@1|root,COG0454@2|Bacteria,1V6N8@1239|Firmicutes,4HITB@91061|Bacilli,27AE7@186823|Alicyclobacillaceae 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 YYD2_k127_3149496_9 997346.HMPREF9374_1644 3.1e-56 206.0 COG4976@1|root,COG4976@2|Bacteria,1V582@1239|Firmicutes,4HI2P@91061|Bacilli 91061|Bacilli S Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 YYD2_k127_3149496_0 1121438.JNJA01000001_gene2267 1.309e-241 763.0 COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2M85I@213115|Desulfovibrionales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 YYD2_k127_3149496_5 552811.Dehly_0101 5.818e-78 272.0 COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi,34CIH@301297|Dehalococcoidia 301297|Dehalococcoidia C Radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - - YYD2_k127_3149496_17 388467.A19Y_0366 1.737e-28 121.0 COG1853@1|root,COG1853@2|Bacteria,1G2RV@1117|Cyanobacteria,1H7U3@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct YYD2_k127_3149496_6 1193181.BN10_50002 2.63e-62 246.0 COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria 201174|Actinobacteria M PFAM peptidase M6, immune inhibitor A - - - - - - - - - - - - Peptidase_M6 YYD2_k127_3180979_2 370438.PTH_1770 1.154e-188 601.0 COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,26067@186807|Peptococcaceae 186801|Clostridia Q PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal - - 1.14.14.9,4.2.1.120,5.3.3.3 ko:K00483,ko:K14534 ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220 M00374,M00375 R02698,R03031,R03299,R10782 RC00046,RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N YYD2_k127_3180979_11 1379698.RBG1_1C00001G0828 5.413e-10 68.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin,Thioredoxin YYD2_k127_3180979_4 945713.IALB_1809 3.009e-113 373.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K00571,ko:K03497 - - - - ko00000,ko01000,ko02048,ko03000,ko03036,ko04812 - - - N6_N4_Mtase,ParBc,RE_Eco29kI YYD2_k127_3180979_7 1379698.RBG1_1C00001G0342 5.755e-64 227.0 COG2908@1|root,COG2908@2|Bacteria,2NPKW@2323|unclassified Bacteria 2|Bacteria S Calcineurin-like phosphoesterase lpxH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - iE2348C_1286.E2348C_0457 Metallophos,Metallophos_2 YYD2_k127_3180979_0 1379698.RBG1_1C00001G0338 3.385e-315 981.0 COG0046@1|root,COG0046@2|Bacteria,2NNPS@2323|unclassified Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C YYD2_k127_3180979_6 1408422.JHYF01000006_gene1266 6.286e-71 258.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,36EWX@31979|Clostridiaceae 186801|Clostridia D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C YYD2_k127_3180979_10 1408304.JAHA01000008_gene1833 3.401e-41 158.0 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,4BWU8@830|Butyrivibrio 186801|Clostridia F Phosphoribosyl transferase domain hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran YYD2_k127_3180979_1 1379698.RBG1_1C00001G1627 3.471e-262 822.0 COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria 2|Bacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 YYD2_k127_3180979_8 648996.Theam_1364 7.275e-63 222.0 COG0302@1|root,COG0302@2|Bacteria,2G40B@200783|Aquificae 200783|Aquificae H GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI YYD2_k127_3180979_5 1379698.RBG1_1C00001G1625 1.177e-81 281.0 COG0294@1|root,COG0294@2|Bacteria,2NNN7@2323|unclassified Bacteria 2|Bacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind YYD2_k127_3180979_9 717605.Theco_0342 1.039e-54 200.0 COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,26R2I@186822|Paenibacillaceae 91061|Bacilli S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N YYD2_k127_3180979_3 945713.IALB_2371 3.082e-172 548.0 COG0481@1|root,COG0481@2|Bacteria 2|Bacteria M GTPase activity lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C YYD2_k127_3226431_4 1379698.RBG1_1C00001G1773 1.859e-86 307.0 COG0457@1|root,COG0457@2|Bacteria,2NP5J@2323|unclassified Bacteria 2|Bacteria S Oxygen tolerance - - - - - - - - - - - - BatD YYD2_k127_3226431_8 1304885.AUEY01000067_gene1312 4.07e-15 85.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,2MHT6@213118|Desulfobacterales 28221|Deltaproteobacteria K PFAM von Willebrand factor type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2 YYD2_k127_3226431_3 880073.Calab_2475 1.665e-98 334.0 COG2304@1|root,COG2304@2|Bacteria,2NP2F@2323|unclassified Bacteria 2|Bacteria S von Willebrand factor (vWF) type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 YYD2_k127_3226431_2 1379698.RBG1_1C00001G1775 3.535e-109 363.0 COG2304@1|root,COG2304@2|Bacteria,2NNYH@2323|unclassified Bacteria 2|Bacteria NU von Willebrand factor (vWF) type A domain batA - - ko:K07114,ko:K12511 - - - - ko00000,ko02000,ko02044 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA YYD2_k127_3226431_5 1379698.RBG1_1C00001G1776 6.333e-39 158.0 COG3088@1|root,COG3088@2|Bacteria,2NS4V@2323|unclassified Bacteria 2|Bacteria O subunit of a heme lyase ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564 - ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018 - - R05712 RC00176 ko00000,ko02000 9.B.14.1 - - CcmH YYD2_k127_3226431_7 880073.Calab_2468 8.1e-30 130.0 COG0760@1|root,COG0760@2|Bacteria,2NRND@2323|unclassified Bacteria 2|Bacteria O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N,SurA_N_3 YYD2_k127_3226431_1 1379698.RBG1_1C00001G1778 7.149e-120 391.0 COG1721@1|root,COG1721@2|Bacteria,2NNQI@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - - - - - - - - - - DUF58 YYD2_k127_3226431_0 1499967.BAYZ01000069_gene1846 3.03e-146 469.0 COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria 2|Bacteria S ATPase associated with various cellular moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 YYD2_k127_3226431_10 111105.HR09_04965 1.674e-07 62.0 COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,2FP8Y@200643|Bacteroidia,22XR6@171551|Porphyromonadaceae 976|Bacteroidetes O Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - YYD2_k127_3226431_6 348780.NP_4470A 7.037e-33 139.0 COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,23SVZ@183963|Halobacteria 183963|Halobacteria I Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids ubiA2 - 2.5.1.42 ko:K17105 ko00564,map00564 - R04520 RC01171 ko00000,ko00001,ko01000 - - - UbiA YYD2_k127_3226431_9 656519.Halsa_0414 3.647e-11 76.0 COG4775@1|root,COG4775@2|Bacteria,1UMDS@1239|Firmicutes,24F0X@186801|Clostridia,3WAA6@53433|Halanaerobiales 186801|Clostridia M PFAM Surface antigen variable number repeat - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD2_k127_3226431_11 1122179.KB890425_gene3438 3.047e-07 63.0 COG3536@1|root,COG3536@2|Bacteria,4PKQ9@976|Bacteroidetes,1IRMG@117747|Sphingobacteriia 976|Bacteroidetes S Protein conserved in bacteria - - - - - - - - - - - - - YYD2_k127_3228773_5 1379698.RBG1_1C00001G1765 2.174e-88 301.0 COG0438@1|root,COG0438@2|Bacteria,2NNTN@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferases group 1 bshA GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 YYD2_k127_3228773_8 1267533.KB906739_gene2679 3.593e-59 214.0 COG2120@1|root,COG2120@2|Bacteria,3Y3NP@57723|Acidobacteria,2JIEH@204432|Acidobacteriia 204432|Acidobacteriia S GlcNAc-PI de-N-acetylase - - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L YYD2_k127_3228773_9 1519464.HY22_00560 2.041e-21 110.0 COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Reprolysin_5 YYD2_k127_3228773_11 1223523.H340_14456 2.843e-15 82.0 COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria 201174|Actinobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 YYD2_k127_3228773_1 1379698.RBG1_1C00001G0402 1.027e-190 618.0 COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria 2|Bacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge YYD2_k127_3228773_10 1379698.RBG1_1C00001G0404 1.741e-19 92.0 2EAFJ@1|root,334IY@2|Bacteria,2NRZR@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 YYD2_k127_3228773_6 1379698.RBG1_1C00001G0434 2.739e-68 243.0 COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria 2|Bacteria M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C YYD2_k127_3228773_0 1379698.RBG1_1C00001G0435 4.835e-283 942.0 COG1747@1|root,COG1747@2|Bacteria,2NP33@2323|unclassified Bacteria 2|Bacteria M methyltransferase greA - - - - - - - - - - - GreA_GreB,GreA_GreB_N,SprA_N YYD2_k127_3228773_7 1379698.RBG1_1C00001G0436 4.153e-66 237.0 COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria 2|Bacteria S Peptidase M28 ywaD - - - - - - - - - - - Peptidase_M28 YYD2_k127_3228773_3 1379698.RBG1_1C00001G1763 6.637e-109 368.0 COG1921@1|root,COG1921@2|Bacteria,2NNT6@2323|unclassified Bacteria 2|Bacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006 Se-cys_synth_N,SelA YYD2_k127_3228773_2 1379698.RBG1_1C00001G1762 2.881e-130 438.0 COG3276@1|root,COG3276@2|Bacteria,2NNQU@2323|unclassified Bacteria 2|Bacteria J Elongation factor SelB, winged helix selB GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112 - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 YYD2_k127_3228773_4 1379698.RBG1_1C00001G1761 7.308e-96 330.0 COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 YYD2_k127_3236637_2 1379698.RBG1_1C00001G1003 1.799e-145 482.0 COG0768@1|root,COG0768@2|Bacteria,2NNYI@2323|unclassified Bacteria 2|Bacteria M Penicillin-binding protein 2 mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase YYD2_k127_3236637_5 1379698.RBG1_1C00001G1004 4.18e-119 395.0 COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria 2|Bacteria D Peptidoglycan polymerase that is essential for cell wall elongation rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE YYD2_k127_3236637_14 1216967.L100_11168 1.522e-13 83.0 COG0793@1|root,COG0793@2|Bacteria,4NEF4@976|Bacteroidetes,1HZ1M@117743|Flavobacteriia,34Q36@308865|Elizabethkingia 976|Bacteroidetes M Aspartyl protease - - - - - - - - - - - - Asp_protease_2,PDZ,PDZ_2 YYD2_k127_3236637_4 1379698.RBG1_1C00001G1008 1.755e-126 413.0 COG0205@1|root,COG0205@2|Bacteria,2NNY2@2323|unclassified Bacteria 2|Bacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK YYD2_k127_3236637_19 78245.Xaut_2468 0.0007951 50.0 COG3637@1|root,COG3637@2|Bacteria,1RKNU@1224|Proteobacteria,2U7U5@28211|Alphaproteobacteria,3EZJK@335928|Xanthobacteraceae 28211|Alphaproteobacteria M PFAM porin - - - ko:K16079 - - - - ko00000,ko02000 1.B.4.2.1 - - OMP_b-brl YYD2_k127_3236637_3 351607.Acel_1114 2.07e-134 435.0 COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4ES5V@85013|Frankiales 201174|Actinobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N YYD2_k127_3236637_0 945713.IALB_1271 7.732e-162 518.0 COG0126@1|root,COG0126@2|Bacteria 2|Bacteria F phosphoglycerate kinase activity pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK YYD2_k127_3236637_7 883126.HMPREF9710_02236 1.978e-82 280.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,4726Q@75682|Oxalobacteraceae 28216|Betaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM YYD2_k127_3236637_12 1379698.RBG1_1C00001G1012 2.426e-16 84.0 COG1314@1|root,COG1314@2|Bacteria,2NQ7S@2323|unclassified Bacteria 2|Bacteria U Preprotein translocase SecG subunit secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG YYD2_k127_3236637_13 1121918.ARWE01000001_gene1063 2.549e-16 83.0 2DRTV@1|root,33D1E@2|Bacteria,1NGE0@1224|Proteobacteria,42X1H@68525|delta/epsilon subdivisions,2WT7W@28221|Deltaproteobacteria,43VCT@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF2914) - - - - - - - - - - - - DUF2914 YYD2_k127_3236637_10 408672.NBCG_01888 1.064e-33 143.0 COG0265@1|root,COG0265@2|Bacteria,2ICC4@201174|Actinobacteria 201174|Actinobacteria O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - - YYD2_k127_3236637_11 1267533.KB906735_gene4861 1.816e-23 113.0 COG0265@1|root,COG0265@2|Bacteria,3Y7GN@57723|Acidobacteria,2JM8V@204432|Acidobacteriia 204432|Acidobacteriia O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - - YYD2_k127_3236637_8 686340.Metal_3843 1.219e-75 273.0 COG4262@1|root,COG4262@2|Bacteria,1QUK8@1224|Proteobacteria,1T460@1236|Gammaproteobacteria,1XEF0@135618|Methylococcales 135618|Methylococcales S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - YYD2_k127_3236637_9 1379698.RBG1_1C00001G1071 1.491e-53 194.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB_2 YYD2_k127_3236637_1 1094980.Mpsy_2456 9.882e-152 492.0 COG0415@1|root,arCOG02840@2157|Archaea,2XTVM@28890|Euryarchaeota,2NAIC@224756|Methanomicrobia 224756|Methanomicrobia L FAD binding domain of DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 YYD2_k127_3236637_15 1122139.KB907865_gene1497 5.411e-09 63.0 COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,1S8N8@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase YYD2_k127_3236637_18 63737.Npun_F1211 4.552e-06 54.0 COG0642@1|root,COG0784@1|root,COG2199@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3850@2|Bacteria,1G09B@1117|Cyanobacteria,1HJ6D@1161|Nostocales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - HAMP,HATPase_c,HisKA,Response_reg,dCache_1 YYD2_k127_3236637_6 521098.Aaci_2352 5.619e-104 354.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,4H9VY@91061|Bacilli,2786F@186823|Alicyclobacillaceae 91061|Bacilli G Belongs to the pyruvate kinase family pyk GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C YYD2_k127_3236637_17 1169144.KB910953_gene3126 1.146e-06 57.0 COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,4HCJW@91061|Bacilli,1ZE67@1386|Bacillus 91061|Bacilli G Polysaccharide deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Cu_amine_oxidN1,LysM,Polysacc_deac_1 YYD2_k127_3238075_0 1379698.RBG1_1C00001G1886 1.375e-91 312.0 COG1058@1|root,COG1058@2|Bacteria,2NP0G@2323|unclassified Bacteria 2|Bacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth YYD2_k127_3238075_1 429009.Adeg_1729 3.027e-32 133.0 COG1514@1|root,COG1514@2|Bacteria,1VEU2@1239|Firmicutes,24MTR@186801|Clostridia,42H6P@68295|Thermoanaerobacterales 186801|Clostridia J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase YYD2_k127_3381942_2 1379698.RBG1_1C00001G1618 1.695e-61 218.0 COG1595@1|root,COG1595@2|Bacteria,2NPHU@2323|unclassified Bacteria 2|Bacteria K RNA polymerase sigma factor sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD2_k127_3381942_5 73044.JNXP01000009_gene2806 2.163e-06 59.0 COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria 201174|Actinobacteria K AntiSigma factor rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - - - - - - - - - - zf-HC2 YYD2_k127_3381942_3 1379698.RBG1_1C00001G0211 2.132e-39 160.0 COG0457@1|root,COG0457@2|Bacteria,2NQ8S@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - - YYD2_k127_3381942_4 1125863.JAFN01000001_gene1954 2.842e-20 106.0 COG0745@1|root,COG2804@1|root,COG0745@2|Bacteria,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE_N YYD2_k127_3381942_0 264732.Moth_1625 7.27e-106 352.0 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,42ENJ@68295|Thermoanaerobacterales 186801|Clostridia F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C YYD2_k127_3381942_1 1379698.RBG1_1C00001G0818 4.817e-94 312.0 COG0605@1|root,COG0605@2|Bacteria,2NP62@2323|unclassified Bacteria 2|Bacteria P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010269,GO:0010447,GO:0016020,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0020012,GO:0030145,GO:0030682,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052059,GO:0052173,GO:0052200,GO:0052385,GO:0052550,GO:0052564,GO:0052567,GO:0052572,GO:0055114,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071291,GO:0071450,GO:0071451,GO:0071944,GO:0072593,GO:0075136,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 ko:K03601,ko:K04564 ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000,ko03400 - - iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iE2348C_1286.E2348C_4213,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSF_1327.ECSF_3769,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNJ661.Rv3846,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050 Sod_Fe_C,Sod_Fe_N YYD2_k127_339514_0 429009.Adeg_1891 5.66e-151 489.0 COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,42FXP@68295|Thermoanaerobacterales 186801|Clostridia E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N YYD2_k127_3466313_1 1196835.A458_20540 1.048e-31 128.0 COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,1RN25@1236|Gammaproteobacteria,1Z1IF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2,TPR_2 YYD2_k127_3466313_0 1121472.AQWN01000002_gene2173 1.543e-66 232.0 COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,2619Q@186807|Peptococcaceae 186801|Clostridia C PFAM Flavodoxin fprA2 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0016661,GO:0016662,GO:0016966,GO:0022900,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050664,GO:0055114,GO:0072593,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B,Pyr_redox_2 YYD2_k127_3516046_3 391612.CY0110_21405 4.647e-53 203.0 COG2304@1|root,COG2304@2|Bacteria,1G1BE@1117|Cyanobacteria,3KIB3@43988|Cyanothece 1117|Cyanobacteria S Von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA YYD2_k127_3516046_8 631362.Thi970DRAFT_00460 4.221e-19 94.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - MerR_1 YYD2_k127_3516046_7 903818.KI912268_gene3050 2.788e-31 126.0 COG0735@1|root,COG0735@2|Bacteria,3Y7UH@57723|Acidobacteria 57723|Acidobacteria P Ferric uptake regulator family - - - ko:K09825 - - - - ko00000,ko03000 - - - FUR YYD2_k127_3516046_0 653733.Selin_2559 0.0 1180.0 COG0376@1|root,COG0376@2|Bacteria 2|Bacteria P catalase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase YYD2_k127_3516046_4 105559.Nwat_2961 7.104e-50 180.0 COG3631@1|root,COG3631@2|Bacteria,1RD0K@1224|Proteobacteria,1S8NU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SnoaL-like domain - - - ko:K06893 - - - - ko00000 - - - SnoaL_2 YYD2_k127_3516046_6 1192034.CAP_6221 1.725e-38 147.0 COG0640@1|root,COG0640@2|Bacteria,1N4FB@1224|Proteobacteria 1224|Proteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 YYD2_k127_3516046_5 1192034.CAP_6222 6.781e-41 158.0 COG3832@1|root,COG3832@2|Bacteria,1N4FU@1224|Proteobacteria,437UM@68525|delta/epsilon subdivisions,2WZ0K@28221|Deltaproteobacteria,2Z12N@29|Myxococcales 28221|Deltaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 YYD2_k127_3516046_2 1379698.RBG1_1C00001G0922 4.366e-63 221.0 COG0350@1|root,COG0350@2|Bacteria,2NPJ5@2323|unclassified Bacteria 2|Bacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ada - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N YYD2_k127_3516046_1 1379698.RBG1_1C00001G0921 4.432e-68 238.0 COG2169@1|root,COG2169@2|Bacteria,2NRJ0@2323|unclassified Bacteria 2|Bacteria K Metal binding domain of Ada adaA1 - 2.1.1.63,3.2.2.21 ko:K10778,ko:K13529,ko:K13530,ko:K15051 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,Endonuclea_NS_2,HTH_18,HhH-GPD YYD2_k127_35270_0 1379698.RBG1_1C00001G0983 9.896e-166 534.0 COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria 2|Bacteria J Ribonuclease E/G family rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 YYD2_k127_35270_1 1191523.MROS_2423 7.296e-79 275.0 COG0223@1|root,COG0223@2|Bacteria 2|Bacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N YYD2_k127_35270_2 1123372.AUIT01000001_gene622 6.78e-45 168.0 COG0242@1|root,COG0242@2|Bacteria,2GHK8@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase YYD2_k127_35270_3 1379698.RBG1_1C00001G0980 9.978e-22 105.0 COG1862@1|root,COG1862@2|Bacteria,2NPY3@2323|unclassified Bacteria 2|Bacteria U Preprotein translocase, YajC yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC YYD2_k127_35270_4 1038860.AXAP01000083_gene433 4.643e-09 66.0 COG0457@1|root,COG0457@2|Bacteria,1N6TJ@1224|Proteobacteria,2UG5W@28211|Alphaproteobacteria,3JZ4G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 YYD2_k127_3617102_2 1379698.RBG1_1C00001G1261 1.83e-13 77.0 COG4966@1|root,COG4966@2|Bacteria 2|Bacteria NU pilus assembly protein PilW pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW YYD2_k127_3617102_0 479434.Sthe_1653 6.623e-167 542.0 COG1012@1|root,COG1012@2|Bacteria,2G5NY@200795|Chloroflexi,27XK3@189775|Thermomicrobia 189775|Thermomicrobia C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh YYD2_k127_3617102_1 1379698.RBG1_1C00001G0205 2.491e-60 215.0 COG0648@1|root,COG0648@2|Bacteria,2NNN3@2323|unclassified Bacteria 2|Bacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 YYD2_k127_3627129_16 521460.Athe_0060 1.376e-61 221.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,42G83@68295|Thermoanaerobacterales 186801|Clostridia C Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind YYD2_k127_3627129_6 634500.EbC_29260 8.621e-121 394.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,3X4FM@551|Erwinia 1236|Gammaproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046872,GO:0071704,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_2206,iSF_1195.SF2102,iSFxv_1172.SFxv_2338,iS_1188.S2225 NTP_transferase YYD2_k127_3627129_3 754476.Q7A_1079 2.694e-131 430.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,4601V@72273|Thiotrichales 72273|Thiotrichales M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd YYD2_k127_3627129_0 1379698.RBG1_1C00001G0844 1.566e-182 583.0 COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria 2|Bacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECUMN_1333.ECUMN_0566,iJN746.PP_2905,iNJ661.Rv2130c DALR_2,tRNA-synt_1e,tRNA-synt_1g YYD2_k127_3627129_7 1382358.JHVN01000020_gene1410 4.439e-113 375.0 COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,4H9SM@91061|Bacilli,21V1J@150247|Anoxybacillus 91061|Bacilli G M42 glutamyl aminopeptidase ysdC - - - - - - - - - - - Peptidase_M42 YYD2_k127_3627129_24 1379698.RBG1_1C00001G0843 1.013e-46 179.0 COG1011@1|root,COG1011@2|Bacteria,2NQ1K@2323|unclassified Bacteria 2|Bacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.1.3.5 ko:K07025,ko:K08723 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 YYD2_k127_3627129_14 945713.IALB_0732 3.523e-80 283.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N YYD2_k127_3627129_39 1121930.AQXG01000015_gene1880 1.624e-13 78.0 COG0586@1|root,COG0586@2|Bacteria 2|Bacteria S FtsZ-dependent cytokinesis yngC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - SNARE_assoc YYD2_k127_3627129_18 1158150.KB906242_gene166 5.347e-56 199.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1WY23@135613|Chromatiales 135613|Chromatiales I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB YYD2_k127_3627129_23 485916.Dtox_0261 9.647e-51 188.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia 186801|Clostridia I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20335 IspD YYD2_k127_3627129_9 868864.Dester_1458 1.815e-97 331.0 COG0809@1|root,COG0809@2|Bacteria,2G3KG@200783|Aquificae 200783|Aquificae J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth YYD2_k127_3627129_5 196367.JNFG01000006_gene7016 6.773e-122 400.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1K2TQ@119060|Burkholderiaceae 28216|Betaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N YYD2_k127_3627129_30 1123508.JH636445_gene6795 4.311e-28 121.0 COG0632@1|root,COG0632@2|Bacteria,2IZ2E@203682|Planctomycetes 203682|Planctomycetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N YYD2_k127_3627129_25 530564.Psta_3588 6.61e-43 164.0 COG0817@1|root,COG0817@2|Bacteria,2IZJS@203682|Planctomycetes 203682|Planctomycetes L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC YYD2_k127_3627129_8 880073.Calab_2557 5.381e-98 336.0 COG0477@1|root,COG2814@2|Bacteria,2NS3M@2323|unclassified Bacteria 2|Bacteria EGP Transmembrane secretion effector bacE - - - - - - - - - - - MFS_1,MFS_3 YYD2_k127_3627129_12 1116472.MGMO_10c00190 4.331e-82 280.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1XEHN@135618|Methylococcales 135618|Methylococcales G Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - Hydrolase_6,Hydrolase_like YYD2_k127_3627129_21 761193.Runsl_0582 1.227e-51 199.0 COG2885@1|root,COG2885@2|Bacteria,4NI3U@976|Bacteroidetes,47MNU@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl_2,OmpA YYD2_k127_3627129_10 1499967.BAYZ01000068_gene1977 1.334e-93 313.0 COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria 2|Bacteria K Transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg YYD2_k127_3627129_36 1123326.JFBL01000002_gene1733 5.493e-20 93.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,42SEH@68525|delta/epsilon subdivisions,2YPE2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria FG Hit family - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT YYD2_k127_3627129_38 1379698.RBG1_1C00001G1485 1.682e-18 86.0 COG0828@1|root,COG0828@2|Bacteria,2NQ1U@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein S21 rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 YYD2_k127_3627129_27 1499967.BAYZ01000073_gene2011 2.794e-38 147.0 COG1610@1|root,COG1610@2|Bacteria,2NPQ9@2323|unclassified Bacteria 2|Bacteria S Yqey-like protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY YYD2_k127_3627129_29 1379698.RBG1_1C00001G1483 1.443e-32 134.0 COG1286@1|root,COG1286@2|Bacteria,2NQ58@2323|unclassified Bacteria 2|Bacteria S Colicin V production protein cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V YYD2_k127_3627129_1 1379698.RBG1_1C00001G1482 2.123e-168 557.0 COG1193@1|root,COG1193@2|Bacteria,2NNS1@2323|unclassified Bacteria 2|Bacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr YYD2_k127_3627129_4 1379698.RBG1_1C00001G1481 1.037e-126 425.0 COG0358@1|root,COG0358@2|Bacteria,2NNNJ@2323|unclassified Bacteria 2|Bacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 YYD2_k127_3627129_11 518766.Rmar_0370 1.147e-92 325.0 COG0497@1|root,COG0497@2|Bacteria,4NE3I@976|Bacteroidetes,1FIR2@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N YYD2_k127_3627129_20 1123288.SOV_5c05070 3.139e-53 199.0 COG2378@1|root,COG2378@2|Bacteria,1TS78@1239|Firmicutes,4H45V@909932|Negativicutes 909932|Negativicutes K WYL domain - - - - - - - - - - - - HTH_11,WYL YYD2_k127_3627129_33 880073.Calab_3127 8.544e-24 118.0 2C4MF@1|root,300D5@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_3627129_31 880073.Calab_3128 1.427e-25 121.0 2API0@1|root,31EM0@2|Bacteria,2NRTE@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_3627129_13 515635.Dtur_0603 1.291e-81 293.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - ko:K09607 - - - - ko00000,ko01000,ko01002 - - - CarboxypepD_reg,FlgD_ig,Peptidase_M6 YYD2_k127_3627129_37 1379698.RBG1_1C00001G0582 4.946e-19 102.0 COG2911@1|root,COG2911@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - - - - - - - - - - - ASH,Cohesin,FlgD_ig,Peptidase_S74 YYD2_k127_3627129_41 411473.RUMCAL_01099 3.998e-09 60.0 COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,3WK5C@541000|Ruminococcaceae 186801|Clostridia K Probable zinc-ribbon domain - - - - - - - - - - - - zf-trcl YYD2_k127_3627129_22 880073.Calab_1128 9.387e-51 204.0 COG1404@1|root,COG1629@1|root,COG1404@2|Bacteria,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - Alpha-amylase,Big_2,CBM_25,Calx-beta,P_proprotein,Peptidase_S8,SBBP,SLH,TonB_dep_Rec,VCBS YYD2_k127_3627129_26 722419.PH505_bq00020 7.496e-40 167.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria,2Q0ZC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB YYD2_k127_3627129_2 635013.TherJR_1754 3.445e-158 518.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,2603X@186807|Peptococcaceae 186801|Clostridia NU PFAM Type II secretion system protein E - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N YYD2_k127_3627129_15 760142.Hipma_1131 3.598e-72 259.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2M7KS@213113|Desulfurellales 28221|Deltaproteobacteria NU Type II secretion system (T2SS), protein F - - - ko:K02653,ko:K12278 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF YYD2_k127_3627129_40 909663.KI867151_gene3115 6.533e-12 72.0 COG4969@1|root,COG4969@2|Bacteria,1QZMY@1224|Proteobacteria,43D4G@68525|delta/epsilon subdivisions 1224|Proteobacteria NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl YYD2_k127_3627129_43 596151.DesfrDRAFT_3563 1.349e-05 55.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,2MBZA@213115|Desulfovibrionales 28221|Deltaproteobacteria U PFAM type II secretion system protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG YYD2_k127_3627129_42 1242864.D187_006599 6.83e-09 68.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2YUJQ@29|Myxococcales 28221|Deltaproteobacteria NU pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 YYD2_k127_3627129_28 401526.TcarDRAFT_2616 1.798e-35 151.0 COG4796@1|root,COG4796@2|Bacteria,1UK31@1239|Firmicutes,4H2BW@909932|Negativicutes 909932|Negativicutes U type II and III secretion system protein pilQ - - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - Secretin,Secretin_N YYD2_k127_3627129_32 1379698.RBG1_1C00001G0236 1.635e-25 111.0 COG2259@1|root,COG2259@2|Bacteria,2NRSH@2323|unclassified Bacteria 2|Bacteria S PFAM Methylamine utilisation protein MauE mauE - - - - - - - - - - - MauE YYD2_k127_3627129_35 1379698.RBG1_1C00001G0235 5.394e-21 99.0 COG0607@1|root,COG0607@2|Bacteria,2NRY7@2323|unclassified Bacteria 2|Bacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese YYD2_k127_3627129_34 1236689.MMALV_12730 3.845e-21 104.0 COG0428@1|root,arCOG00576@2157|Archaea,2XXNC@28890|Euryarchaeota 28890|Euryarchaeota P Zinc iron permease - - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip YYD2_k127_3627129_17 1379698.RBG1_1C00001G1318 1.65e-56 210.0 COG0392@1|root,COG0392@2|Bacteria,2NPGZ@2323|unclassified Bacteria 2|Bacteria S Lysylphosphatidylglycerol synthase TM region mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM YYD2_k127_3627129_19 1379698.RBG1_1C00001G1319 5.392e-55 198.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 YYD2_k127_3660907_0 555079.Toce_1203 8.081e-101 336.0 COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,42F7D@68295|Thermoanaerobacterales 186801|Clostridia C Best Blastp hit gi 6685602 sp Q57957 KORB_METJA 2-OXOGLUTARATE SYNTHASE SUBUNIT KORB (2-KETOGLUTARATE OXIDOREDUCTASE BETA CHAIN) (KOR) (2-OXOGLUTARATE-FERREDOXIN OXIDOREDUCTASE BETA SUBUNIT) gi 2129229 pir A64367 pyruvate synthase (EC 1.2.7.1) beta chain - Methanococcus jannaschii gi 1591241 gb AAB98531.1 '(U67503) 2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB) Methanococcus jannaschii ', score korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C YYD2_k127_3660907_2 909663.KI867149_gene3458 3.922e-53 193.0 COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,2MRMB@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase korC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR YYD2_k127_3660907_3 1051646.VITU9109_21764 5.879e-42 157.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1XX25@135623|Vibrionales 135623|Vibrionales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK YYD2_k127_3660907_1 1236689.MMALV_14900 6.081e-55 205.0 COG3875@1|root,arCOG02046@2157|Archaea,2XVDD@28890|Euryarchaeota 28890|Euryarchaeota S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 YYD2_k127_3674056_2 1121920.AUAU01000006_gene301 1.065e-39 152.0 2BYAB@1|root,32R2Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_3674056_1 338969.Rfer_4108 1.603e-53 193.0 COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VSAQ@28216|Betaproteobacteria,4AEGJ@80864|Comamonadaceae 28216|Betaproteobacteria S 3-demethylubiquinone-9 3-methyltransferase - - - - - - - - - - - - 3-dmu-9_3-mt YYD2_k127_3674056_0 443598.AUFA01000001_gene1294 3.758e-64 225.0 COG2514@1|root,COG2514@2|Bacteria,1RBC7@1224|Proteobacteria,2U5JP@28211|Alphaproteobacteria,3JR7C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MA20_22790 - 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase YYD2_k127_3703910_7 1158338.JNLJ01000001_gene905 2.508e-52 196.0 COG2885@1|root,COG2885@2|Bacteria,2G4S4@200783|Aquificae 200783|Aquificae M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_YMGG,OmpA,TSP_3 YYD2_k127_3703910_6 665571.STHERM_c09350 4.669e-59 222.0 COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes 203691|Spirochaetes L COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain - - - ko:K09749 - - - - ko00000 - - - FapA,Jag_N YYD2_k127_3703910_12 1120998.AUFC01000016_gene52 4.708e-25 109.0 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,3WD27@538999|Clostridiales incertae sedis 186801|Clostridia T Sigma-54 interaction domain - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_3703910_15 1304885.AUEY01000022_gene3410 2.44e-15 81.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_3703910_20 639030.JHVA01000001_gene3473 0.0008178 50.0 COG1587@1|root,COG2203@1|root,COG1587@2|Bacteria,COG2203@2|Bacteria,3Y68Z@57723|Acidobacteria,2JK7D@204432|Acidobacteriia 204432|Acidobacteriia T ANTAR - - - - - - - - - - - - ANTAR,GAF,GAF_2,HEM4 YYD2_k127_3703910_17 1293054.HSACCH_02291 3.991e-10 69.0 COG5581@1|root,COG5581@2|Bacteria 2|Bacteria M regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed pilZ - - - - - - - - - - - PilZ,YcgR_2 YYD2_k127_3703910_1 1379698.RBG1_1C00001G1108 2.491e-94 318.0 COG1191@1|root,COG1191@2|Bacteria,2NPMN@2323|unclassified Bacteria 2|Bacteria K Sigma-70 region 3 - - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 YYD2_k127_3703910_11 1122197.ATWI01000008_gene3254 4.166e-28 124.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RQSP@1236|Gammaproteobacteria,46CPM@72275|Alteromonadaceae 1236|Gammaproteobacteria N COG0455 ATPases involved in chromosome partitioning - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,ParA YYD2_k127_3703910_16 469381.Dpep_0274 4.201e-12 78.0 COG1419@1|root,COG1419@2|Bacteria,3TAHV@508458|Synergistetes 508458|Synergistetes N PFAM GTP-binding signal recognition particle SRP54 G- domain - - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 YYD2_k127_3703910_0 574087.Acear_1624 9.258e-220 701.0 COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,3WABD@53433|Halanaerobiales 186801|Clostridia N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP YYD2_k127_3703910_2 1117108.PAALTS15_26539 3.286e-91 311.0 COG1377@1|root,COG1377@2|Bacteria,1TPRP@1239|Firmicutes,4HB7Y@91061|Bacilli,26TRR@186822|Paenibacillaceae 91061|Bacilli N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 YYD2_k127_3703910_9 1120985.AUMI01000015_gene1680 6.372e-40 158.0 COG1684@1|root,COG1684@2|Bacteria,1TRB2@1239|Firmicutes,4H3BC@909932|Negativicutes 909932|Negativicutes N flagellar biosynthetic protein FliR fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 YYD2_k127_3703910_13 1123367.C666_05760 1.27e-23 102.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2VU8S@28216|Betaproteobacteria,2KX39@206389|Rhodocyclales 206389|Rhodocyclales N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 YYD2_k127_3703910_3 243231.GSU0423 4.717e-88 297.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,42NDZ@68525|delta/epsilon subdivisions,2WKCN@28221|Deltaproteobacteria,43UJF@69541|Desulfuromonadales 28221|Deltaproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP YYD2_k127_3703910_19 264462.Bd3326 0.0005068 49.0 COG3190@1|root,COG3190@2|Bacteria,1NHJX@1224|Proteobacteria,437MR@68525|delta/epsilon subdivisions,2MU5D@213481|Bdellovibrionales,2X2VV@28221|Deltaproteobacteria 213481|Bdellovibrionales N Polar flagellar assembly protein FliO - - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO YYD2_k127_3703910_10 1121936.AUHI01000004_gene1579 1.446e-30 128.0 COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,4HC56@91061|Bacilli 91061|Bacilli N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliY GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032879,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1902021,GO:2000145 - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - CheC,FliMN_C YYD2_k127_3703910_4 243276.TPANIC_0721 1.432e-71 253.0 COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes 203691|Spirochaetes N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C YYD2_k127_3703910_18 862908.BMS_0555 4.794e-05 53.0 COG1580@1|root,COG1580@2|Bacteria,1NBUX@1224|Proteobacteria,42RSV@68525|delta/epsilon subdivisions,2MTD5@213481|Bdellovibrionales,2WR7K@28221|Deltaproteobacteria 213481|Bdellovibrionales N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL YYD2_k127_3703910_14 273068.TTE1432 2.225e-16 80.0 COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,24RWI@186801|Clostridia,42H8U@68295|Thermoanaerobacterales 186801|Clostridia N PFAM flagellar flbD - - ko:K02385 - - - - ko00000,ko02035 - - - FlbD YYD2_k127_3703910_8 990073.ATHU01000001_gene767 8.622e-41 169.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,42NGP@68525|delta/epsilon subdivisions,2YN81@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Flagellar hook protein flgE flgE GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flagellin_IN,Flg_bb_rod,Flg_bbr_C YYD2_k127_3712557_1 204669.Acid345_1334 1.088e-65 229.0 COG5295@1|root,COG5295@2|Bacteria,3Y72W@57723|Acidobacteria,2JM9T@204432|Acidobacteriia 2|Bacteria UW Hep Hag repeat protein yeeJ - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF5122,Peptidase_S74,YadA_head,YadA_stalk YYD2_k127_3712557_0 215803.DB30_8826 3.795e-85 286.0 28H95@1|root,2Z7KY@2|Bacteria,1RA0C@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF4256) - - - - - - - - - - - - DUF4256 YYD2_k127_3712557_2 1379698.RBG1_1C00001G0198 1.301e-19 98.0 COG2885@1|root,COG5276@1|root,COG2885@2|Bacteria,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - - - - - - - - - - - Phenol_MetA_deg YYD2_k127_3729_1 1379270.AUXF01000004_gene3145 1.685e-41 172.0 COG4726@1|root,COG4726@2|Bacteria,1ZUS8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Pilus assembly protein PilX - - - - - - - - - - - - - YYD2_k127_3729_0 1379698.RBG1_1C00001G0370 5.119e-121 419.0 COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria 2|Bacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 YYD2_k127_3729_2 1177594.MIC448_2490003 2.697e-32 136.0 COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4FKF8@85023|Microbacteriaceae 201174|Actinobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family tsnR - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind YYD2_k127_3744284_0 595460.RRSWK_01928 1.928e-55 215.0 COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes 203682|Planctomycetes T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10,WD40 YYD2_k127_3744284_2 305700.B447_20905 0.0009772 47.0 2DYJH@1|root,34A3F@2|Bacteria,1P2TV@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - YYD2_k127_3744284_1 3218.PP1S202_1V6.1 4.626e-08 58.0 COG0451@1|root,KOG1502@2759|Eukaryota,37JYY@33090|Viridiplantae,3G71H@35493|Streptophyta 35493|Streptophyta V Male sterility protein - - 1.1.1.354 ko:K15891 ko00900,ko00909,ko01130,map00900,map00909,map01130 - R10412 RC00649 ko00000,ko00001,ko01000 - - - Epimerase YYD2_k127_3782081_1 1192034.CAP_8124 2.846e-205 655.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2YUB0@29|Myxococcales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran YYD2_k127_3782081_3 314230.DSM3645_05435 4.471e-135 445.0 COG1236@1|root,COG1236@2|Bacteria,2IXNS@203682|Planctomycetes 203682|Planctomycetes J Exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL YYD2_k127_3782081_5 411483.FAEPRAA2165_02811 1.715e-08 64.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3WGST@541000|Ruminococcaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA YYD2_k127_3782081_4 290397.Adeh_1611 7.985e-18 98.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria 1224|Proteobacteria L nucleotidyltransferase DNA polymerase involved in DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS YYD2_k127_3782081_0 521674.Plim_1325 2.061e-276 882.0 COG0587@1|root,COG0587@2|Bacteria,2IWSE@203682|Planctomycetes 203682|Planctomycetes L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP YYD2_k127_3782081_2 1379270.AUXF01000006_gene5 1.639e-175 567.0 COG0317@1|root,COG0317@2|Bacteria,1ZT5M@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS YYD2_k127_3793457_1 373903.Hore_08140 5.159e-200 632.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,3WABP@53433|Halanaerobiales 186801|Clostridia J class II (D K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon YYD2_k127_3793457_0 1519464.HY22_12340 8.753e-238 761.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1FEI3@1090|Chlorobi 1090|Chlorobi GJM Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III YYD2_k127_3793457_18 1122604.JONR01000017_gene4334 2.932e-37 148.0 COG4359@1|root,COG4359@2|Bacteria,1REUD@1224|Proteobacteria,1S47B@1236|Gammaproteobacteria,1X63D@135614|Xanthomonadales 135614|Xanthomonadales E Putative Phosphatase - - - - - - - - - - - - HAD YYD2_k127_3793457_19 278957.ABEA03000006_gene4188 4.63e-33 138.0 COG0730@1|root,COG0730@2|Bacteria,46V52@74201|Verrucomicrobia,3K9AP@414999|Opitutae 414999|Opitutae S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE YYD2_k127_3793457_14 1379698.RBG1_1C00001G1839 4.231e-54 209.0 COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 YYD2_k127_3793457_15 935948.KE386494_gene842 4.63e-50 186.0 COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,42GBY@68295|Thermoanaerobacterales 186801|Clostridia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin YYD2_k127_3793457_2 311424.DhcVS_852 4.105e-191 602.0 COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia 301297|Dehalococcoidia I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth YYD2_k127_3793457_21 1410612.JNKO01000002_gene2447 2.892e-10 69.0 COG1309@1|root,COG1309@2|Bacteria,1V1C8@1239|Firmicutes,24FZ9@186801|Clostridia,2PTWS@265975|Oribacterium 186801|Clostridia K YsiA-like protein, C-terminal region - - - - - - - - - - - - TetR_C_4,TetR_N YYD2_k127_3793457_3 1379698.RBG1_1C00001G1855 2.755e-182 581.0 COG0499@1|root,COG0499@2|Bacteria,2NNQE@2323|unclassified Bacteria 2|Bacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD YYD2_k127_3793457_4 1379698.RBG1_1C00001G1854 5.251e-174 552.0 COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria 2|Bacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N YYD2_k127_3793457_9 1519464.HY22_02585 5.347e-91 309.0 COG1209@1|root,COG1209@2|Bacteria,1FD8Z@1090|Chlorobi 1090|Chlorobi M Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase YYD2_k127_3793457_13 1379698.RBG1_1C00001G0112 1.58e-55 203.0 2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_3793457_12 1379698.RBG1_1C00001G0113 5.713e-64 230.0 28MYQ@1|root,2ZB5K@2|Bacteria,2NPC8@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_3793457_17 1379698.RBG1_1C00001G0114 1.005e-39 155.0 29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_3793457_10 1379698.RBG1_1C00001G0115 3.842e-83 285.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_3793457_8 632292.Calhy_2037 2.555e-93 317.0 COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,42EVQ@68295|Thermoanaerobacterales 186801|Clostridia G TIGRFAM bifunctional phosphoglucose phosphomannose isomerase - - 5.3.1.8,5.3.1.9 ko:K15916 ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R01819,R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 - - - SIS,bact-PGI_C YYD2_k127_3793457_5 273068.TTE2334 5.266e-115 391.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales 186801|Clostridia G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9,2.7.9.2 ko:K01007,ko:K08483 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C YYD2_k127_3793457_6 1379698.RBG1_1C00001G1819 6.772e-101 361.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_3793457_20 297246.lpp0540 1.812e-23 102.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SX88@1236|Gammaproteobacteria,1JEY3@118969|Legionellales 118969|Legionellales G PTS HPr component phosphorylation site ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr YYD2_k127_3793457_11 1379698.RBG1_1C00001G1623 8.154e-82 285.0 COG0758@1|root,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria 2|Bacteria LU DNA recombination-mediator protein A dprA - 5.99.1.2 ko:K03168,ko:K04096 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_processg_A YYD2_k127_3793457_7 1379698.RBG1_1C00001G1624 1.333e-94 318.0 COG0536@1|root,COG0536@2|Bacteria,2NNS6@2323|unclassified Bacteria 2|Bacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000003,GO:0000160,GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007059,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0019954,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0034622,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042254,GO:0042255,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043933,GO:0043934,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1990904 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 YYD2_k127_3794147_2 1300345.LF41_901 5.971e-137 453.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XDED@135614|Xanthomonadales 135614|Xanthomonadales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Sigma54_activat YYD2_k127_3794147_5 247490.KSU1_C0842 3.261e-110 382.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process - - - - - - - - - - - iAF987.Gmet_0348 Cofac_haem_bdg,PDZ_2,Peptidase_M1,Peptidase_M28 YYD2_k127_3794147_3 1121430.JMLG01000019_gene1656 6.799e-124 413.0 COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,24CA4@186801|Clostridia,260IP@186807|Peptococcaceae 186801|Clostridia S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC YYD2_k127_3794147_6 926550.CLDAP_26360 8.124e-76 277.0 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2G7I4@200795|Chloroflexi 200795|Chloroflexi UW Hep Hag repeat protein - - - - - - - - - - - - - YYD2_k127_3794147_18 795359.TOPB45_0383 8.773e-13 77.0 COG3945@1|root,COG3945@2|Bacteria 2|Bacteria P hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin YYD2_k127_3794147_9 525904.Tter_1587 6.159e-62 233.0 COG0843@1|root,COG0843@2|Bacteria,2NNTQ@2323|unclassified Bacteria 2|Bacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxA - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 YYD2_k127_3794147_8 411154.GFO_1406 1.496e-62 227.0 COG1277@1|root,COG1277@2|Bacteria,4NGGR@976|Bacteroidetes,1HXF5@117743|Flavobacteriia 976|Bacteroidetes S nitrous oxide - - - ko:K19341 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC2_membrane_2,ABC2_membrane_5 YYD2_k127_3794147_7 746697.Aeqsu_0138 1.538e-65 231.0 COG1131@1|root,COG1131@2|Bacteria,4NG9T@976|Bacteroidetes,1HYYD@117743|Flavobacteriia 976|Bacteroidetes V ABC-type multidrug transport system ATPase component - - - ko:K19340 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC_tran YYD2_k127_3794147_4 1191523.MROS_1106 5.87e-118 392.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process nosD - - ko:K07218 - - - - ko00000 - - - NosD YYD2_k127_3794147_15 1191523.MROS_1105 3.555e-30 124.0 COG4314@1|root,COG4314@2|Bacteria 2|Bacteria C lipoprotein involved in nitrous oxide reduction nosL - - ko:K19342 - - - - ko00000 - - - NosL YYD2_k127_3794147_10 123214.PERMA_1258 1.482e-56 205.0 COG4314@1|root,COG4314@2|Bacteria,2G4TU@200783|Aquificae 200783|Aquificae C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - - YYD2_k127_3794147_0 1191523.MROS_1104 2e-323 998.0 COG4263@1|root,COG4263@2|Bacteria 2|Bacteria C nitrous-oxide reductase activity nosZ GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234 1.7.2.4,1.9.3.1 ko:K00376,ko:K02275 ko00190,ko00910,ko01100,ko01120,map00190,map00910,map01100,map01120 M00155,M00529 R00081,R02804 RC00016,RC02861 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,Cupredoxin_1 YYD2_k127_3794147_16 1191523.MROS_1103 2.846e-27 117.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cytochrom_C,Cytochrome_CBB3 YYD2_k127_3794147_14 1121930.AQXG01000001_gene1021 4.844e-39 149.0 COG1959@1|root,COG1959@2|Bacteria,4NURI@976|Bacteroidetes 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - Rrf2 YYD2_k127_3794147_13 1366050.N234_03595 1.694e-46 179.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria,1K07H@119060|Burkholderiaceae 28216|Betaproteobacteria NU Type II secretion system tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF YYD2_k127_3794147_12 296591.Bpro_2556 3.981e-51 193.0 COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,4A9JG@80864|Comamonadaceae 28216|Betaproteobacteria U Type II secretion system - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF YYD2_k127_3794147_1 1121405.dsmv_0813 6.539e-157 507.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2MI0I@213118|Desulfobacterales 28221|Deltaproteobacteria U PFAM Type II IV secretion system protein - - - ko:K02283,ko:K03609 - - - - ko00000,ko02035,ko02044,ko03036,ko04812 - - - CbiA,FHA,T2SSE YYD2_k127_3794147_11 443143.GM18_2436 4.008e-54 207.0 COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,43SJ6@69541|Desulfuromonadales 28221|Deltaproteobacteria D Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,CBP_BcsQ,ParA,Response_reg YYD2_k127_3794147_17 1304872.JAGC01000003_gene2359 5.136e-25 113.0 COG4961@1|root,COG4961@2|Bacteria,1NIG7@1224|Proteobacteria,42X7K@68525|delta/epsilon subdivisions,2WSKV@28221|Deltaproteobacteria,2M9N1@213115|Desulfovibrionales 28221|Deltaproteobacteria U Putative Flp pilus-assembly TadE/G-like - - - - - - - - - - - - Tad YYD2_k127_3836515_1 1379698.RBG1_1C00001G0505 2.697e-11 76.0 COG0308@1|root,COG0308@2|Bacteria,2NPPZ@2323|unclassified Bacteria 2|Bacteria E Peptidase family M1 domain - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M1 YYD2_k127_3836515_0 555079.Toce_2076 1.492e-44 166.0 COG0454@1|root,COG0456@2|Bacteria,1V6D6@1239|Firmicutes,24KC1@186801|Clostridia,42GT3@68295|Thermoanaerobacterales 186801|Clostridia K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 YYD2_k127_3902467_0 1321778.HMPREF1982_00984 0.0 1194.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,267M9@186813|unclassified Clostridiales 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran YYD2_k127_3902467_4 1121930.AQXG01000004_gene2868 1.375e-12 80.0 COG1572@1|root,COG2911@1|root,COG4733@1|root,COG1572@2|Bacteria,COG2911@2|Bacteria,COG4733@2|Bacteria,4NYS6@976|Bacteroidetes,1IZ9T@117747|Sphingobacteriia 976|Bacteroidetes S Parallel beta-helix repeats - - - - - - - - - - - - - YYD2_k127_3902467_2 401526.TcarDRAFT_1265 1.468e-33 138.0 298ZI@1|root,2ZW3A@2|Bacteria,1V7FU@1239|Firmicutes,4H5FQ@909932|Negativicutes 909932|Negativicutes S ECF transporter, substrate-specific component - - - - - - - - - - - - ECF_trnsprt YYD2_k127_3902467_3 477974.Daud_1148 1.884e-31 132.0 COG0500@1|root,COG2226@2|Bacteria,1V6EF@1239|Firmicutes,24JZ4@186801|Clostridia,262N8@186807|Peptococcaceae 186801|Clostridia Q PFAM methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 YYD2_k127_3902467_5 1095772.CAHH01000040_gene2417 9.651e-08 59.0 COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria 201174|Actinobacteria OU Membrane protein implicated in regulation of membrane protease activity nfeD - - - - - - - - - - - NfeD YYD2_k127_3902467_1 247490.KSU1_C0202 1.023e-98 332.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflC GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - Band_7 YYD2_k127_3903058_1 1233950.IW22_18060 8.327e-06 57.0 COG0457@1|root,COG0457@2|Bacteria,4NPJG@976|Bacteroidetes,1IJ3M@117743|Flavobacteriia,3ZP1G@59732|Chryseobacterium 976|Bacteroidetes S Aerotolerance regulator BatC batC - - - - - - - - - - - TPR_1,TPR_16,TPR_2 YYD2_k127_3903058_0 1379698.RBG1_1C00001G0285 4.853e-30 121.0 COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria 2|Bacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N YYD2_k127_3924371_15 1340493.JNIF01000004_gene858 6.1e-57 207.0 COG1402@1|root,COG1402@2|Bacteria 2|Bacteria I creatininase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase YYD2_k127_3924371_16 1379698.RBG1_1C00001G1526 1.357e-56 207.0 2CBA8@1|root,30BZT@2|Bacteria,2NR2H@2323|unclassified Bacteria 2|Bacteria S Exopolysaccharide biosynthesis protein YbjH - - - - - - - - - - - - YjbH YYD2_k127_3924371_23 1123508.JH636439_gene573 1.856e-37 152.0 COG0115@1|root,COG0115@2|Bacteria,2IY3N@203682|Planctomycetes 203682|Planctomycetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 YYD2_k127_3924371_9 1121324.CLIT_2c01880 7.573e-80 284.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,25QW7@186804|Peptostreptococcaceae 186801|Clostridia EH Anthranilate synthase component I, N terminal region pabB - 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01657,ko:K01665,ko:K03342,ko:K13950 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Anth_synt_I_N,Chorismate_bind YYD2_k127_3924371_18 243231.GSU1012 1.011e-51 199.0 COG1906@1|root,COG1906@2|Bacteria,1RAQQ@1224|Proteobacteria,42QZ0@68525|delta/epsilon subdivisions,2WMXK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF401) - - - ko:K09133 - - - - ko00000 - - - DUF401 YYD2_k127_3924371_22 518766.Rmar_2628 9.215e-39 153.0 COG1595@1|root,COG1595@2|Bacteria,4NQE0@976|Bacteroidetes,1FISP@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K TIGRFAM RNA polymerase sigma factor, sigma-70 family rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD2_k127_3924371_30 639030.JHVA01000001_gene1961 0.0002737 51.0 COG5662@1|root,COG5662@2|Bacteria,3Y4JS@57723|Acidobacteria,2JJ7U@204432|Acidobacteriia 204432|Acidobacteriia K AntiSigma factor - - - - - - - - - - - - zf-HC2 YYD2_k127_3924371_26 653733.Selin_1769 2.96e-22 109.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity degP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 YYD2_k127_3924371_25 379066.GAU_1903 4.505e-25 113.0 COG0599@1|root,COG0599@2|Bacteria,1ZTPF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD YYD2_k127_3924371_4 1379698.RBG1_1C00001G1524 1.512e-125 443.0 COG2911@1|root,COG2911@2|Bacteria,2NQ89@2323|unclassified Bacteria 2|Bacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K07277,ko:K09800 - - - - ko00000,ko02000,ko03029 1.B.33 - - AsmA_2,DUF748,TamB YYD2_k127_3924371_8 1379698.RBG1_1C00001G1523 2.05e-80 291.0 COG4775@1|root,COG4775@2|Bacteria,2NQXR@2323|unclassified Bacteria 2|Bacteria M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD2_k127_3924371_3 264732.Moth_1652 4.097e-131 429.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales 186801|Clostridia H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 YYD2_k127_3924371_5 316067.Geob_1979 1.033e-114 381.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,43SZM@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans YYD2_k127_3924371_10 555079.Toce_0270 3.175e-77 265.0 COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,249X0@186801|Clostridia,42GDI@68295|Thermoanaerobacterales 186801|Clostridia S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 YYD2_k127_3924371_11 1379698.RBG1_1C00001G1516 7.439e-63 245.0 COG2982@1|root,COG2982@2|Bacteria,2NRT5@2323|unclassified Bacteria 2|Bacteria M AsmA-like C-terminal region - - - ko:K07289,ko:K09800 - - - - ko00000,ko02000 - - - AsmA,AsmA_1,AsmA_2,DUF3971,DctA-YdbH YYD2_k127_3924371_19 573370.DMR_30950 1.467e-51 191.0 COG0765@1|root,COG0765@2|Bacteria,1MWF0@1224|Proteobacteria,42NEI@68525|delta/epsilon subdivisions,2WJP9@28221|Deltaproteobacteria,2M8HK@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 YYD2_k127_3924371_6 1462526.BN990_04384 6.034e-91 306.0 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli,4C5F4@84406|Virgibacillus 91061|Bacilli E AAA domain, putative AbiEii toxin, Type IV TA system - - 3.6.3.21 ko:K02028,ko:K10038 ko02010,map02010 M00227,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.2 - - ABC_tran YYD2_k127_3924371_7 945713.IALB_0461 2.243e-82 301.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family aprN - - - - - - - - - - - Peptidase_S8 YYD2_k127_3924371_29 311424.DhcVS_1405 2.493e-08 65.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,2G7Y4@200795|Chloroflexi,34DMA@301297|Dehalococcoidia 301297|Dehalococcoidia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg YYD2_k127_3924371_28 204669.Acid345_1814 8.26e-18 92.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,3Y62K@57723|Acidobacteria,2JMK5@204432|Acidobacteriia 204432|Acidobacteriia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg YYD2_k127_3924371_12 1379698.RBG1_1C00001G0958 4.179e-62 224.0 COG1561@1|root,COG1561@2|Bacteria,2NPG5@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF1732) yicC - - ko:K03316 - - - - ko00000 2.A.36 - - DUF1732,YicC_N YYD2_k127_3924371_21 653733.Selin_2413 1.224e-43 166.0 COG0194@1|root,COG0194@2|Bacteria 2|Bacteria F guanylate kinase activity gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin YYD2_k127_3924371_0 1379698.RBG1_1C00001G0961 3.835e-277 871.0 COG0550@1|root,COG0550@2|Bacteria,2NNS8@2323|unclassified Bacteria 2|Bacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom YYD2_k127_3924371_20 592010.GCWU000182_001546 4.635e-50 190.0 COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4HARA@91061|Bacilli,27DTX@186827|Aerococcaceae 91061|Bacilli D Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase YYD2_k127_3924371_13 880073.Calab_0162 5.153e-62 218.0 COG5405@1|root,COG5405@2|Bacteria,2NP72@2323|unclassified Bacteria 2|Bacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome YYD2_k127_3924371_2 518766.Rmar_1879 1.809e-170 546.0 COG1220@1|root,COG1220@2|Bacteria,4NFI2@976|Bacteroidetes,1FIQI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small YYD2_k127_3924371_1 1379698.RBG1_1C00001G1453 2.368e-193 612.0 COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria 2|Bacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - iG2583_1286.G2583_3081,iIT341.HP0183 SHMT YYD2_k127_3924371_27 1379698.RBG1_1C00001G1452 6.712e-22 98.0 COG0011@1|root,COG0011@2|Bacteria 2|Bacteria H TIGRFAM Protein of - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Thiamine_BP YYD2_k127_3924371_24 638303.Thal_0887 9.198e-27 112.0 COG1324@1|root,COG1324@2|Bacteria,2G58I@200783|Aquificae 200783|Aquificae P CutA1 divalent ion tolerance protein cutA - - ko:K03926 - - - - ko00000 - - - CutA1 YYD2_k127_3924371_17 1379698.RBG1_1C00001G1448 5.577e-55 196.0 COG1327@1|root,COG1327@2|Bacteria,2NPEU@2323|unclassified Bacteria 2|Bacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone YYD2_k127_3924371_14 1379698.RBG1_1C00001G1447 6.915e-60 216.0 COG0805@1|root,COG0805@2|Bacteria,2NPGB@2323|unclassified Bacteria 2|Bacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC YYD2_k127_398499_0 880073.Calab_2995 1.479e-199 635.0 COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria 2|Bacteria O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C YYD2_k127_398499_4 686340.Metal_2831 7.31e-29 122.0 COG1943@1|root,COG1943@2|Bacteria,1PUZT@1224|Proteobacteria,1TAPE@1236|Gammaproteobacteria,1XGFG@135618|Methylococcales 135618|Methylococcales L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp YYD2_k127_398499_3 945713.IALB_1083 1.057e-42 179.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Calx-beta,CarboxypepD_reg,LVIVD,TSP_3 YYD2_k127_398499_2 1232410.KI421426_gene1437 1.492e-49 184.0 arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,43UQJ@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_398499_5 683837.lse_2655 1.724e-16 83.0 2E5AU@1|root,3302Y@2|Bacteria,1VB5Y@1239|Firmicutes,4HPUD@91061|Bacilli,26KPZ@186820|Listeriaceae 91061|Bacilli S Src homology 3 domains - - - - - - - - - - - - SH3_1,SH3_2 YYD2_k127_398499_1 635013.TherJR_2454 5.435e-75 269.0 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae 186801|Clostridia H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM YYD2_k127_398499_6 1379698.RBG1_1C00001G0429 3.89e-07 53.0 COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria 2|Bacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 YYD2_k127_4008026_5 269799.Gmet_0638 1.029e-79 269.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,42QS6@68525|delta/epsilon subdivisions,2WMPD@28221|Deltaproteobacteria,43TH5@69541|Desulfuromonadales 28221|Deltaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C YYD2_k127_4008026_17 59374.Fisuc_1409 1.71e-24 103.0 COG0199@1|root,COG0199@2|Bacteria 2|Bacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 YYD2_k127_4008026_15 941770.GL622181_gene891 1.143e-35 139.0 COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,4HH32@91061|Bacilli,3F64E@33958|Lactobacillaceae 91061|Bacilli J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 YYD2_k127_4008026_7 1121104.AQXH01000010_gene2432 3.862e-60 215.0 COG0097@1|root,COG0097@2|Bacteria,4NGJM@976|Bacteroidetes,1IRC9@117747|Sphingobacteriia 976|Bacteroidetes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 YYD2_k127_4008026_16 290397.Adeh_1930 1.628e-28 118.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2WQ8U@28221|Deltaproteobacteria,2YVEW@29|Myxococcales 28221|Deltaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p YYD2_k127_4008026_8 1304885.AUEY01000001_gene3231 1.04e-52 190.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C YYD2_k127_4008026_19 945713.IALB_0930 4.062e-17 83.0 COG1841@1|root,COG1841@2|Bacteria 2|Bacteria J maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 YYD2_k127_4008026_11 1379698.RBG1_1C00001G1577 7.691e-44 164.0 COG0200@1|root,COG0200@2|Bacteria,2NPNV@2323|unclassified Bacteria 2|Bacteria J Binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A YYD2_k127_4008026_0 1379698.RBG1_1C00001G1576 4.213e-186 593.0 COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria 2|Bacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY YYD2_k127_4008026_6 644966.Tmar_2275 1.436e-64 231.0 COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,3WCG7@538999|Clostridiales incertae sedis 186801|Clostridia F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS20110 ADK,ADK_lid YYD2_k127_4008026_3 1069080.KB913028_gene492 4.91e-93 311.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H2VZ@909932|Negativicutes 909932|Negativicutes E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 YYD2_k127_4008026_13 1379698.RBG1_1C00001G1573 9.694e-38 143.0 COG0361@1|root,COG0361@2|Bacteria,2NPNU@2323|unclassified Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a YYD2_k127_4008026_20 660470.Theba_0701 6.002e-12 65.0 COG0257@1|root,COG0257@2|Bacteria,2GDKI@200918|Thermotogae 200918|Thermotogae J Belongs to the bacterial ribosomal protein bL36 family rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 YYD2_k127_4008026_10 1449126.JQKL01000050_gene2698 2.629e-50 181.0 COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,26987@186813|unclassified Clostridiales 186801|Clostridia J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 YYD2_k127_4008026_9 370438.PTH_0346 1.683e-50 182.0 COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia,261G0@186807|Peptococcaceae 186801|Clostridia J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 YYD2_k127_4008026_4 1379698.RBG1_1C00001G1569 5.663e-84 282.0 COG0522@1|root,COG0522@2|Bacteria,2NPCC@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 YYD2_k127_4008026_1 1379698.RBG1_1C00001G1568 7.199e-125 407.0 COG0202@1|root,COG0202@2|Bacteria,2NNQQ@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L YYD2_k127_4008026_14 1379698.RBG1_1C00001G1567 1.907e-37 146.0 COG0203@1|root,COG0203@2|Bacteria,2NPYQ@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein L17 rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02879,ko:K16193 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 YYD2_k127_4008026_12 269799.Gmet_3020 3.725e-41 160.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,42QQP@68525|delta/epsilon subdivisions,2WMZE@28221|Deltaproteobacteria,43UMJ@69541|Desulfuromonadales 28221|Deltaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf YYD2_k127_4008026_2 1379698.RBG1_1C00001G1178 2.084e-101 341.0 COG0240@1|root,COG0240@2|Bacteria,2NP1N@2323|unclassified Bacteria 2|Bacteria I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N YYD2_k127_4008026_18 1191523.MROS_2512 1.298e-19 96.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding ycgE - - ko:K19591,ko:K22491 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR_1 YYD2_k127_4030569_11 1162668.LFE_1804 4.576e-78 268.0 COG0372@1|root,COG0372@2|Bacteria 2|Bacteria C Belongs to the citrate synthase family gltA - 2.3.3.1,4.1.3.34 ko:K01647,ko:K15234 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R00351,R00354 RC00004,RC00067,RC00502 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt YYD2_k127_4030569_15 1121396.KB893071_gene1265 1.73e-54 199.0 COG0489@1|root,COG0489@2|Bacteria,1R6AC@1224|Proteobacteria,42NTJ@68525|delta/epsilon subdivisions,2WM95@28221|Deltaproteobacteria,2MJ5Z@213118|Desulfobacterales 28221|Deltaproteobacteria D protein tyrosine kinase activity - - - - - - - - - - - - - YYD2_k127_4030569_30 521045.Kole_2161 1.167e-19 90.0 COG1146@1|root,COG1146@2|Bacteria,2GDEK@200918|Thermotogae 200918|Thermotogae C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4 YYD2_k127_4030569_2 1232437.KL661988_gene235 4.956e-144 464.0 COG0674@1|root,COG0674@2|Bacteria,1MWCI@1224|Proteobacteria,42NJY@68525|delta/epsilon subdivisions,2WIW3@28221|Deltaproteobacteria,2MHPN@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II vorA - 1.2.7.11,1.2.7.3,1.2.7.7 ko:K00174,ko:K00186 ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197,R07160,R08566,R08567 RC00004,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1307 PFOR_II,POR_N YYD2_k127_4030569_5 1265505.ATUG01000001_gene4024 1.237e-118 385.0 COG1013@1|root,COG1013@2|Bacteria,1N0HY@1224|Proteobacteria,42MTM@68525|delta/epsilon subdivisions,2WJS6@28221|Deltaproteobacteria,2MIRW@213118|Desulfobacterales 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C YYD2_k127_4030569_16 1121396.KB893071_gene1269 3.059e-52 190.0 COG1014@1|root,COG1014@2|Bacteria,1R92Y@1224|Proteobacteria,42QJI@68525|delta/epsilon subdivisions,2WMFZ@28221|Deltaproteobacteria,2MJ4M@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family - - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR YYD2_k127_4030569_20 255470.cbdbA845 2.261e-43 164.0 COG1905@1|root,COG1905@2|Bacteria,2G6Q5@200795|Chloroflexi,34CKC@301297|Dehalococcoidia 301297|Dehalococcoidia C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx YYD2_k127_4030569_0 255470.cbdbA684 7.638e-242 761.0 COG1894@1|root,COG1894@2|Bacteria,2G5K9@200795|Chloroflexi,34D48@301297|Dehalococcoidia 301297|Dehalococcoidia C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB YYD2_k127_4030569_17 335541.Swol_1700 1.187e-50 189.0 COG3383@1|root,COG3383@2|Bacteria,1V5BD@1239|Firmicutes,24ER9@186801|Clostridia 186801|Clostridia C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - iHN637.CLJU_RS03470 Fer2_4,Fer4,Fer4_21,Fer4_7 YYD2_k127_4030569_23 589924.Ferp_1231 9.099e-39 150.0 COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2477Y@183980|Archaeoglobi 183980|Archaeoglobi C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11 YYD2_k127_4030569_18 1125863.JAFN01000001_gene3569 1.585e-47 183.0 2DREW@1|root,33BF6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4030569_21 1379698.RBG1_1C00001G1098 2.358e-43 164.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator spo0A - - ko:K03413,ko:K07699 ko02020,ko02024,ko02030,map02020,map02024,map02030 M00485,M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg,Spo0A_C YYD2_k127_4030569_28 1379698.RBG1_1C00001G0890 8.619e-26 110.0 COG0745@1|root,COG0745@2|Bacteria 1379698.RBG1_1C00001G0890|- T phosphorelay signal transduction system - - - - - - - - - - - - - YYD2_k127_4030569_19 880073.Calab_1982 4.848e-47 174.0 COG0691@1|root,COG0691@2|Bacteria,2NPFK@2323|unclassified Bacteria 2|Bacteria O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 - ko:K03664 - - - - ko00000 - - - SmpB YYD2_k127_4030569_10 1379698.RBG1_1C00001G0723 7.617e-83 295.0 COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria 2|Bacteria M Ami_3 amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 YYD2_k127_4030569_9 1031288.AXAA01000004_gene1953 1.973e-86 293.0 COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,36DHC@31979|Clostridiaceae 186801|Clostridia M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race YYD2_k127_4030569_14 457570.Nther_1950 1.239e-57 207.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia 186801|Clostridia F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like YYD2_k127_4030569_32 1408473.JHXO01000009_gene3379 3.93e-12 74.0 2BXUX@1|root,32R23@2|Bacteria,4NR4Y@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_4030569_27 1089551.KE386572_gene4189 4.05e-26 112.0 2A0NG@1|root,32XDJ@2|Bacteria,1N3J7@1224|Proteobacteria,2UD9K@28211|Alphaproteobacteria,4BSDS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_4030569_25 331869.BAL199_01834 9.146e-30 121.0 2A0NG@1|root,32XDJ@2|Bacteria,1N3J7@1224|Proteobacteria,2UD9K@28211|Alphaproteobacteria,4BSDS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_4030569_4 926550.CLDAP_31550 5.861e-135 450.0 COG4579@1|root,COG4579@2|Bacteria 2|Bacteria F [isocitrate dehydrogenase (NADP+)] phosphatase activity aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK YYD2_k127_4030569_22 338963.Pcar_2070 3.018e-43 165.0 COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,43THX@69541|Desulfuromonadales 28221|Deltaproteobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp YYD2_k127_4030569_26 1267535.KB906767_gene4689 1.791e-29 124.0 COG1959@1|root,COG1959@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding - - - - - - - - - - - - Rrf2 YYD2_k127_4030569_8 1379698.RBG1_1C00001G0735 1.704e-96 321.0 COG0396@1|root,COG0396@2|Bacteria,2NNYE@2323|unclassified Bacteria 2|Bacteria O ABC transporter sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran YYD2_k127_4030569_1 1379698.RBG1_1C00001G0736 6.765e-231 722.0 COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria 2|Bacteria O FeS assembly protein SufB sufB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - ko:K07033,ko:K09014 - - - - ko00000 - - - UPF0051 YYD2_k127_4030569_12 926554.KI912639_gene1730 3.387e-63 233.0 COG0719@1|root,COG0719@2|Bacteria,1WJ1E@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O TIGRFAM FeS assembly protein SufD - - - ko:K09015 - - - - ko00000 - - - UPF0051 YYD2_k127_4030569_31 1123392.AQWL01000003_gene137 7.479e-19 91.0 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,2VUAP@28216|Betaproteobacteria 28216|Betaproteobacteria P Rieske-like [2Fe-2S] domain - - - ko:K05710,ko:K18087 ko00360,ko00621,ko01100,ko01120,ko01220,map00360,map00621,map01100,map01120,map01220 M00543,M00545 R05261,R05262,R05263,R05264,R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske,Rieske_2 YYD2_k127_4030569_3 1136177.KCA1_1248 3.65e-141 460.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,3F3UP@33958|Lactobacillaceae 91061|Bacilli E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 YYD2_k127_4030569_24 525378.HMPREF0793_1505 7.523e-38 148.0 COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,4GXNX@90964|Staphylococcaceae 91061|Bacilli C NifU homolog involved in Fe-S cluster formation nifU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - ko:K04488 - - - - ko00000 - - - NifU_N YYD2_k127_4030569_29 754477.Q7C_272 2.278e-25 108.0 COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S8YV@1236|Gammaproteobacteria,463JX@72273|Thiotrichales 72273|Thiotrichales S PaaD-like protein - - - - - - - - - - - - FeS_assembly_P YYD2_k127_4030569_6 1379698.RBG1_1C00001G1665 1.773e-110 370.0 COG0845@1|root,COG0845@2|Bacteria,2NQ2U@2323|unclassified Bacteria 2|Bacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion acrA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 YYD2_k127_4030569_7 1379698.RBG1_1C00001G1666 1.904e-103 340.0 COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria 2|Bacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_4030569_13 941449.dsx2_0305 1.21e-57 205.0 COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria,2M9AF@213115|Desulfovibrionales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_4035155_1 1283300.ATXB01000001_gene1749 1.949e-87 292.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1XDJM@135618|Methylococcales 135618|Methylococcales C Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N YYD2_k127_4035155_3 1379698.RBG1_1C00001G0295 2.895e-64 228.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - ko:K04013,ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_C552,Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1 YYD2_k127_4035155_2 1379698.RBG1_1C00001G0296 2.905e-87 300.0 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 YYD2_k127_4035155_0 1379698.RBG1_1C00001G0297 5.627e-159 511.0 COG4881@1|root,COG4881@2|Bacteria 2|Bacteria - - cbcU - - - - - - - - - - - NrfD YYD2_k127_4038692_5 596151.DesfrDRAFT_0992 1.64e-12 74.0 COG4961@1|root,COG4961@2|Bacteria,1NIG7@1224|Proteobacteria,42X7K@68525|delta/epsilon subdivisions,2WSKV@28221|Deltaproteobacteria,2M9N1@213115|Desulfovibrionales 28221|Deltaproteobacteria U Putative Flp pilus-assembly TadE/G-like - - - - - - - - - - - - Tad YYD2_k127_4038692_0 13689.BV96_00405 3.022e-53 202.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2U4KB@28211|Alphaproteobacteria,2K1M8@204457|Sphingomonadales 204457|Sphingomonadales U Belongs to the GSP D family - - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N YYD2_k127_4038692_1 1238182.C882_0871 1.38e-32 138.0 COG3745@1|root,COG3745@2|Bacteria,1MYVE@1224|Proteobacteria,2V9JX@28211|Alphaproteobacteria,2JWBX@204441|Rhodospirillales 204441|Rhodospirillales U Flp pilus assembly protein RcpC/CpaB - - - - - - - - - - - - RcpC,SAF YYD2_k127_4038692_6 1089553.Tph_c05460 1.545e-09 65.0 COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,42H5Q@68295|Thermoanaerobacterales 186801|Clostridia U TadE-like protein - - - - - - - - - - - - TadE YYD2_k127_4038692_3 1121406.JAEX01000002_gene912 1.058e-27 119.0 COG1989@1|root,COG1989@2|Bacteria,1R34X@1224|Proteobacteria,42V6M@68525|delta/epsilon subdivisions,2WRP6@28221|Deltaproteobacteria,2MCVZ@213115|Desulfovibrionales 28221|Deltaproteobacteria NOU PFAM Peptidase A24A, prepilin type IV - - 3.4.23.43 ko:K02278 - - - - ko00000,ko01000,ko02035,ko02044 - - - Peptidase_A24 YYD2_k127_4038692_8 926566.Terro_3894 3.134e-05 48.0 COG3847@1|root,COG3847@2|Bacteria,3Y5Y3@57723|Acidobacteria 57723|Acidobacteria U PFAM Flp Fap pilin component - - - ko:K02651 ko04112,map04112 - - - ko00000,ko00001,ko02035,ko02044 - - - Flp_Fap YYD2_k127_4038692_7 926566.Terro_3894 3.691e-06 51.0 COG3847@1|root,COG3847@2|Bacteria,3Y5Y3@57723|Acidobacteria 57723|Acidobacteria U PFAM Flp Fap pilin component - - - ko:K02651 ko04112,map04112 - - - ko00000,ko00001,ko02035,ko02044 - - - Flp_Fap YYD2_k127_4038692_4 338966.Ppro_2697 3.025e-20 96.0 COG1430@1|root,COG1430@2|Bacteria,1N7U4@1224|Proteobacteria,42VKG@68525|delta/epsilon subdivisions,2WSD0@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 YYD2_k127_4038692_2 248742.XP_005651940.1 1.665e-29 123.0 COG0436@1|root,KOG0258@2759|Eukaryota,37NSY@33090|Viridiplantae,34K0W@3041|Chlorophyta 3041|Chlorophyta E alanine aminotransferase - - 2.6.1.2,2.6.1.4,2.6.1.44 ko:K14272 ko00220,ko00250,ko00260,ko00630,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00260,map00630,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00171,M00532 R00258,R00369,R00372 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_4041032_0 1379698.RBG1_1C00001G0606 2.863e-228 721.0 COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria 2|Bacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN678.aspS,iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon YYD2_k127_4041032_4 644966.Tmar_2172 1.324e-109 366.0 COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,3WCEH@538999|Clostridiales incertae sedis 186801|Clostridia T PhoH-like protein phoH - - ko:K06217 - - - - ko00000 - - - PhoH YYD2_k127_4041032_5 880073.Calab_2813 1.58e-109 382.0 COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria 2|Bacteria S 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD YYD2_k127_4041032_12 638303.Thal_0337 6.992e-23 103.0 COG0319@1|root,COG0319@2|Bacteria,2G5AR@200783|Aquificae 200783|Aquificae J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 YYD2_k127_4041032_9 398767.Glov_2733 1.029e-58 220.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42QX1@68525|delta/epsilon subdivisions,2WMNH@28221|Deltaproteobacteria,43TQD@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM CBS domain containing protein corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC,DUF21 YYD2_k127_4041032_2 1379698.RBG1_1C00001G0933 9.996e-118 415.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02584,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022,ko03000 - - - FHA,GAF,GAF_2,HTH_8,Sigma54_activat YYD2_k127_4041032_10 1379698.RBG1_1C00001G1821 2.022e-25 116.0 COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria 2|Bacteria H Biotin/lipoate A/B protein ligase family lipM GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB YYD2_k127_4041032_1 1379698.RBG1_1C00001G1820 5.038e-220 722.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec YYD2_k127_4041032_6 1379698.RBG1_1C00001G1818 1.56e-90 308.0 COG2067@1|root,COG2067@2|Bacteria,2NR34@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - YYD2_k127_4041032_11 1379698.RBG1_1C00001G1817 2.21e-23 117.0 COG0308@1|root,COG0308@2|Bacteria,2NRIZ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase N - - - - - - - - - - - - CarbopepD_reg_2,Cofac_haem_bdg,NAAA-beta,Peptidase_M1,Phospholip_B YYD2_k127_4041032_7 1379698.RBG1_1C00001G1816 4.5e-69 261.0 COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NR9R@2323|unclassified Bacteria 2|Bacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - DUF2723,PMT_2,TPR_8 YYD2_k127_4041032_3 1379698.RBG1_1C00001G0069 5.23e-117 412.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NRP6@2323|unclassified Bacteria 2|Bacteria O Subtilase family - - - ko:K13276 - - - - ko00000,ko01000,ko01002,ko03110 - - - CHU_C,FlgD_ig,PKD,Peptidase_S8 YYD2_k127_4041032_13 880073.Calab_0921 5.815e-21 109.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF4157,FctA,Peptidase_M43 YYD2_k127_4041032_8 1231392.OCGS_1452 1.433e-62 239.0 COG4412@1|root,COG4412@2|Bacteria,1MWWV@1224|Proteobacteria,2U8R8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Immune inhibitor A peptidase M6 - - - - - - - - - - - - Peptidase_M6 YYD2_k127_4057319_1 1379698.RBG1_1C00001G0446 2.89e-123 405.0 COG3869@1|root,COG3869@2|Bacteria,2NR28@2323|unclassified Bacteria 2|Bacteria E ATP:guanido phosphotransferase, C-terminal catalytic domain mcsB GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 2.7.14.1,2.7.3.2,2.7.3.3 ko:K00933,ko:K00934,ko:K19405 ko00330,ko01100,map00330,map01100 M00047 R00554,R01881,R11090 RC00002,RC00203 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ATP-gua_Ptrans YYD2_k127_4057319_0 1379698.RBG1_1C00001G0445 0.0 1229.0 COG0542@1|root,COG0542@2|Bacteria,2NNKN@2323|unclassified Bacteria 2|Bacteria O C-terminal, D2-small domain, of ClpB protein clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR YYD2_k127_4057319_3 1305836.AXVE01000011_gene1038 2.915e-33 132.0 2AEMC@1|root,314H9@2|Bacteria,1W0UA@1239|Firmicutes,4HRRY@91061|Bacilli 91061|Bacilli S Protein of unknown function (DUF1761) - - - - - - - - - - - - DUF1761 YYD2_k127_4057319_4 378806.STAUR_2272 2.724e-30 121.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2WQ2U@28221|Deltaproteobacteria,2YVJI@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 YYD2_k127_4057319_2 886293.Sinac_1729 3.954e-65 239.0 COG0501@1|root,COG0501@2|Bacteria,2J0GY@203682|Planctomycetes 203682|Planctomycetes O CAAX prenyl protease N-terminal, five membrane helices - - - - - - - - - - - - Peptidase_M48,Peptidase_M48_N YYD2_k127_4086735_2 357808.RoseRS_0754 1.338e-13 74.0 COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi,375J5@32061|Chloroflexia 32061|Chloroflexia O PFAM cytochrome c-type biogenesis protein CcmB - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB YYD2_k127_4086735_0 443144.GM21_2026 1.213e-124 412.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,43THP@69541|Desulfuromonadales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_4086735_1 443143.GM18_2043 6.872e-91 315.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 YYD2_k127_4107500_30 468059.AUHA01000005_gene2544 1.073e-21 100.0 2DPXD@1|root,333T1@2|Bacteria,4NZI7@976|Bacteroidetes 976|Bacteroidetes S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 YYD2_k127_4107500_24 316274.Haur_0199 2.788e-36 143.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family dinB - - - - - - - - - - - DUF664,DinB YYD2_k127_4107500_12 639030.JHVA01000001_gene1214 2.127e-140 473.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia 2|Bacteria KLT Tetratricopeptide repeats - - 2.7.11.1 ko:K08282,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16,TPR_2,TPR_8 YYD2_k127_4107500_7 1121920.AUAU01000007_gene543 4.079e-165 525.0 COG0604@1|root,COG0604@2|Bacteria,3Y4X4@57723|Acidobacteria 57723|Acidobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N YYD2_k127_4107500_26 391603.FBALC1_08338 2.229e-30 134.0 COG5640@1|root,COG5640@2|Bacteria,4P71W@976|Bacteroidetes,1IBSM@117743|Flavobacteriia 976|Bacteroidetes O Trypsin-like serine protease - - - - - - - - - - - - Trypsin YYD2_k127_4107500_16 1403313.AXBR01000009_gene751 7.546e-106 350.0 COG2321@1|root,COG2321@2|Bacteria,1TQKF@1239|Firmicutes,4HB7I@91061|Bacilli,1ZCSY@1386|Bacillus 91061|Bacilli S Putative neutral zinc metallopeptidase XK27_03670 - - ko:K07054 - - - - ko00000 - - - Zn_peptidase YYD2_k127_4107500_27 867845.KI911784_gene2290 8.616e-26 117.0 COG1266@1|root,COG1266@2|Bacteria,2G7NB@200795|Chloroflexi,377D7@32061|Chloroflexia 32061|Chloroflexia S CAAX protease self-immunity - - - - - - - - - - - - Abi YYD2_k127_4107500_35 1506583.JQJY01000005_gene2134 4.409e-06 58.0 2E0CU@1|root,32VZP@2|Bacteria,4NUGS@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_4107500_23 1121378.KB899773_gene622 1.525e-39 167.0 28HH2@1|root,33750@2|Bacteria 2|Bacteria M Thiol-activated cytolysin - - - ko:K11031 ko02024,map02024 - - - ko00000,ko00001,ko02042 - - - Thiol_cytolysin YYD2_k127_4107500_20 880073.Calab_3335 1.209e-62 226.0 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity - - - - - - - - - - - - FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding YYD2_k127_4107500_4 880073.Calab_3334 6.966e-188 604.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7 YYD2_k127_4107500_3 204669.Acid345_0471 1.242e-201 649.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - - YYD2_k127_4107500_18 880073.Calab_3331 1.886e-92 325.0 2919D@1|root,2ZNWG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4107500_9 880073.Calab_3330 3.212e-151 490.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,2NS2I@2323|unclassified Bacteria 2|Bacteria O Pyridine nucleotide-disulphide oxidoreductase trxB_2 - 1.18.1.2,1.19.1.1,1.8.1.9 ko:K00384,ko:K21567 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Fer4,Fer4_10,Pyr_redox_3 YYD2_k127_4107500_31 1191523.MROS_0167 5.968e-18 85.0 2DRHT@1|root,33BTG@2|Bacteria 2|Bacteria S lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - YYD2_k127_4107500_13 1191523.MROS_0166 9.705e-140 453.0 COG0119@1|root,COG0119@2|Bacteria 2|Bacteria E Belongs to the alpha-IPM synthase homocitrate synthase family leuA3 - 2.3.3.13,2.3.3.14 ko:K01649,ko:K01655 ko00290,ko00300,ko00620,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00620,map01100,map01110,map01120,map01130,map01210,map01230 M00030,M00432,M00433 R00271,R01213 RC00004,RC00067,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like YYD2_k127_4107500_14 880073.Calab_0345 8.297e-137 439.0 COG0189@1|root,COG0189@2|Bacteria,2NNM4@2323|unclassified Bacteria 2|Bacteria HJ Belongs to the RimK family lysX - 6.3.1.17,6.3.2.32,6.3.2.41,6.3.2.43 ko:K05827,ko:K05844,ko:K14940,ko:K18310 ko00250,ko00300,ko00680,ko01100,ko01120,ko01210,ko01230,map00250,map00300,map00680,map01100,map01120,map01210,map01230 M00031 R09401,R09775,R10677,R10678 RC00064,RC00090,RC00141,RC03233 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RimK YYD2_k127_4107500_10 1191523.MROS_0164 6.555e-144 464.0 COG0002@1|root,COG0002@2|Bacteria 2|Bacteria E N-acetyl-gamma-glutamyl-phosphate reductase activity argC - 1.2.1.38 ko:K00145,ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R03443,R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC YYD2_k127_4107500_21 1191523.MROS_0163 2.593e-52 192.0 COG0121@1|root,COG0121@2|Bacteria 2|Bacteria S cellular modified histidine biosynthetic process - - - - - - - - - - - - GATase_4 YYD2_k127_4107500_17 1191523.MROS_0162 1.866e-92 311.0 COG0548@1|root,COG0548@2|Bacteria 2|Bacteria E Belongs to the acetylglutamate kinase family. ArgB subfamily lysZ GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8,3.5.1.16 ko:K00930,ko:K01438,ko:K05828,ko:K05831 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R00669,R02649,R09107,R09776,R09779,R10930,R10933 RC00002,RC00043,RC00064,RC00090,RC00300 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Peptidase_M20 YYD2_k127_4107500_8 880073.Calab_0349 1.105e-151 491.0 COG4992@1|root,COG4992@2|Bacteria,2NP0N@2323|unclassified Bacteria 2|Bacteria E acetylornithine and succinylornithine aminotransferase lysJ - 2.6.1.11,2.6.1.17 ko:K00821,ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00031,M00763,M00845 R02283,R04475,R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,Peptidase_M20 YYD2_k127_4107500_34 1379698.RBG1_1C00001G0237 2.799e-08 67.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,LVIVD YYD2_k127_4107500_36 694427.Palpr_0773 6.425e-05 56.0 2ENNG@1|root,33G9U@2|Bacteria,4NZMI@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_4107500_29 1121957.ATVL01000008_gene4553 5.343e-22 112.0 COG5295@1|root,COG5295@2|Bacteria,4NKG1@976|Bacteroidetes,47NK6@768503|Cytophagia 976|Bacteroidetes MUW domain, Protein - - - - - - - - - - - - Peptidase_S74 YYD2_k127_4107500_28 1121957.ATVL01000008_gene4553 7.941e-25 121.0 COG5295@1|root,COG5295@2|Bacteria,4NKG1@976|Bacteroidetes,47NK6@768503|Cytophagia 976|Bacteroidetes MUW domain, Protein - - - - - - - - - - - - Peptidase_S74 YYD2_k127_4107500_22 1123267.JONN01000001_gene1239 1.311e-41 166.0 2C1YS@1|root,2ZD2Y@2|Bacteria 2|Bacteria S Protease prsW family - - - - - - - - - - - - PrsW-protease YYD2_k127_4107500_1 1123267.JONN01000001_gene1238 1.196e-242 783.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP YYD2_k127_4107500_25 1303518.CCALI_01897 1.834e-34 140.0 COG1595@1|root,COG1595@2|Bacteria 1303518.CCALI_01897|- K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - - YYD2_k127_4107500_33 1121921.KB898707_gene1117 2.39e-09 62.0 COG1366@1|root,COG1366@2|Bacteria,1PCVS@1224|Proteobacteria,1SCT3@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the anti-sigma-factor antagonist family spoIIAA - - - - - - - - - - - STAS,STAS_2 YYD2_k127_4107500_32 1168059.KB899087_gene851 1.676e-15 82.0 COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,2UCGB@28211|Alphaproteobacteria,3F07N@335928|Xanthobacteraceae 28211|Alphaproteobacteria T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2 YYD2_k127_4107500_15 234267.Acid_2394 2.866e-130 427.0 COG0505@1|root,COG0505@2|Bacteria,3Y31Y@57723|Acidobacteria 57723|Acidobacteria EF TIGRFAM Carbamoyl-phosphate synthase, small subunit carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase YYD2_k127_4107500_0 1267535.KB906767_gene717 0.0 1326.0 COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria,2JIJZ@204432|Acidobacteriia 204432|Acidobacteriia F TIGRFAM carbamoyl-phosphate synthase, large subunit carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS YYD2_k127_4107500_11 596152.DesU5LDRAFT_3428 2.93e-141 458.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,42N6F@68525|delta/epsilon subdivisions,2WKX7@28221|Deltaproteobacteria,2M8S4@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM 2-nitropropane dioxygenase NPD - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO YYD2_k127_4107500_6 1379698.RBG1_1C00001G1680 1.025e-165 532.0 COG0513@1|root,COG0513@2|Bacteria,2NP0A@2323|unclassified Bacteria 2|Bacteria JKL Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C YYD2_k127_4107500_2 234267.Acid_5940 2.748e-236 759.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase YYD2_k127_4107500_5 1047013.AQSP01000093_gene11 2.03e-179 569.0 COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 YYD2_k127_4107500_19 1047013.AQSP01000077_gene2274 5.492e-79 268.0 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 YYD2_k127_4187031_2 760192.Halhy_3331 2.128e-45 169.0 COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,1IS7E@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase rprX - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA YYD2_k127_4187031_0 1410613.JNKF01000001_gene2410 7.062e-85 288.0 COG0745@1|root,COG0745@2|Bacteria,4NF1I@976|Bacteroidetes,2FNZV@200643|Bacteroidia 976|Bacteroidetes K transcriptional regulatory protein rprY - - - - - - - - - - - Response_reg,Trans_reg_C YYD2_k127_4187031_4 251221.35210693 2.445e-25 114.0 COG3324@1|root,COG3324@2|Bacteria,1G8CB@1117|Cyanobacteria 1117|Cyanobacteria S Glyoxalase-like domain - - - ko:K06996 - - - - ko00000 - - - Glyoxalase YYD2_k127_4187031_1 391625.PPSIR1_06381 2.311e-59 219.0 COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria 1224|Proteobacteria KLT serine threonine protein kinase pknB - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase YYD2_k127_4187031_5 1254432.SCE1572_21210 4.829e-12 69.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD2_k127_4190897_1 296591.Bpro_2918 0.0002055 51.0 COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2VM3G@28216|Betaproteobacteria,4AC44@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM CHAD domain containing protein - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHAD,CYTH YYD2_k127_4240499_8 1047013.AQSP01000140_gene2449 3.416e-44 166.0 COG1418@1|root,COG1418@2|Bacteria,2NPXI@2323|unclassified Bacteria 2|Bacteria S mRNA catabolic process - - - ko:K06950,ko:K09163 - - - - ko00000 - - - HD YYD2_k127_4240499_0 398767.Glov_1510 2.389e-144 463.0 COG0673@1|root,COG0673@2|Bacteria,1PXE1@1224|Proteobacteria,42MSE@68525|delta/epsilon subdivisions,2WKIS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - 1.1.1.335 ko:K13016 ko00520,map00520 - R10140 RC00182 ko00000,ko00001,ko01000,ko01005 - - - GFO_IDH_MocA,GFO_IDH_MocA_C YYD2_k127_4240499_12 762966.HMPREF9439_00743 6.894e-06 55.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria,4PR1U@995019|Sutterellaceae 28216|Betaproteobacteria O Redoxin bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA YYD2_k127_4240499_3 1125863.JAFN01000001_gene2600 6.049e-104 354.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria 1224|Proteobacteria C PFAM FAD linked oxidase domain protein dld GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.1.1.303,1.1.1.4,1.1.2.4,1.1.3.15 ko:K00004,ko:K00102,ko:K00104 ko00620,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map00650,map01100,map01110,map01120,map01130 - R00197,R00475,R02855,R02946,R10504 RC00042,RC00044,RC00205,RC00525 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 YYD2_k127_4240499_9 240015.ACP_0479 1.277e-38 157.0 COG3005@1|root,COG3005@2|Bacteria,3Y4BJ@57723|Acidobacteria,2JJ2B@204432|Acidobacteriia 204432|Acidobacteriia C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 YYD2_k127_4240499_7 684949.ATTJ01000001_gene843 1.982e-46 181.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1 YYD2_k127_4240499_4 933262.AXAM01000021_gene456 4.655e-102 352.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF_2,HTH_8,Sigma54_activat YYD2_k127_4240499_2 1379698.RBG1_1C00001G0518 7.611e-106 376.0 COG0515@1|root,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 YYD2_k127_4240499_11 335543.Sfum_1432 3.398e-17 88.0 COG3350@1|root,COG3350@2|Bacteria,1NE2T@1224|Proteobacteria,42VZQ@68525|delta/epsilon subdivisions,2WSDU@28221|Deltaproteobacteria 28221|Deltaproteobacteria S YHS domain - - - - - - - - - - - - YHS YYD2_k127_4240499_6 237368.SCABRO_01552 7.005e-53 199.0 COG4191@1|root,COG4191@2|Bacteria,2IZY8@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA YYD2_k127_4240499_1 1125863.JAFN01000001_gene1446 1.004e-139 464.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_4240499_10 690850.Desaf_2671 5.617e-19 100.0 COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PU9@68525|delta/epsilon subdivisions,2WU8U@28221|Deltaproteobacteria,2M8K7@213115|Desulfovibrionales 28221|Deltaproteobacteria MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP YYD2_k127_4240499_5 290397.Adeh_4105 4.474e-83 295.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2YZUC@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23 YYD2_k127_4300454_7 765911.Thivi_3711 4.105e-50 198.0 COG4870@1|root,COG4870@2|Bacteria,1RJ0M@1224|Proteobacteria,1SES2@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Papain family cysteine protease - - - - - - - - - - - - Peptidase_C1 YYD2_k127_4300454_4 1379698.RBG1_1C00001G1819 3.84e-116 407.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4300454_3 1379698.RBG1_1C00001G1819 6.334e-117 409.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4300454_2 452637.Oter_1447 1.223e-150 484.0 COG1294@1|root,COG1294@2|Bacteria,46UN7@74201|Verrucomicrobia,3K8IE@414999|Opitutae 414999|Opitutae C Cytochrome BD ubiquinol oxidase subunit II - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II YYD2_k127_4300454_1 945713.IALB_0420 1.089e-193 613.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I YYD2_k127_4300454_5 639282.DEFDS_1066 8.22e-82 278.0 COG0410@1|root,COG0410@2|Bacteria,2GEK0@200930|Deferribacteres 200930|Deferribacteres E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran YYD2_k127_4300454_12 436114.SYO3AOP1_0137 2.901e-23 108.0 COG1472@1|root,COG1472@2|Bacteria,2G52S@200783|Aquificae 200783|Aquificae G Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 YYD2_k127_4300454_14 765952.PUV_23630 2.293e-09 63.0 2EQQP@1|root,33IAK@2|Bacteria,2JGJU@204428|Chlamydiae 204428|Chlamydiae S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 YYD2_k127_4300454_13 1379698.RBG1_1C00001G0145 2.198e-17 87.0 2EPKR@1|root,33H7C@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4300454_6 1379698.RBG1_1C00001G0146 1.387e-72 254.0 COG0356@1|root,COG0356@2|Bacteria,2NPRQ@2323|unclassified Bacteria 2|Bacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A YYD2_k127_4300454_11 1379698.RBG1_1C00001G0147 1.178e-25 108.0 COG0636@1|root,COG0636@2|Bacteria,2NQ21@2323|unclassified Bacteria 2|Bacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C YYD2_k127_4300454_8 1379698.RBG1_1C00001G0148 2.507e-36 144.0 COG0711@1|root,COG0711@2|Bacteria,2NQ34@2323|unclassified Bacteria 2|Bacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B YYD2_k127_4300454_10 373903.Hore_17830 3.708e-27 117.0 COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia,3WATA@53433|Halanaerobiales 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP YYD2_k127_4300454_0 1379698.RBG1_1C00001G0150 1.879e-239 748.0 COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N YYD2_k127_4300454_9 268407.PWYN_14280 4.659e-28 116.0 COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,4HB0E@91061|Bacilli,26SNU@186822|Paenibacillaceae 91061|Bacilli C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSB619.SA_RS10970,iYO844.BSU36820 ATP-synt YYD2_k127_4301179_2 1379698.RBG1_1C00001G0285 1.532e-76 263.0 COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria 2|Bacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N YYD2_k127_4301179_0 1047013.AQSP01000142_gene195 1.18e-97 331.0 COG0787@1|root,COG0787@2|Bacteria,2NP3R@2323|unclassified Bacteria 2|Bacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N YYD2_k127_4301179_3 1107311.Q767_15005 1.674e-33 136.0 COG3485@1|root,COG3485@2|Bacteria,4NEZ1@976|Bacteroidetes,1I01Q@117743|Flavobacteriia,2NVGG@237|Flavobacterium 976|Bacteroidetes Q Dioxygenase - - 1.13.11.3 ko:K00449 ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220 - R01631,R03549 RC00388,RC00953 br01602,ko00000,ko00001,ko01000 - - - Dioxygenase_C YYD2_k127_4301179_1 1379698.RBG1_1C00001G0103 7.043e-94 314.0 COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria 2|Bacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 YYD2_k127_4316792_1 1219084.AP014508_gene1039 1.782e-156 503.0 COG0156@1|root,COG0156@2|Bacteria,2GCC8@200918|Thermotogae 200918|Thermotogae H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_4316792_8 906968.Trebr_0917 2.031e-15 81.0 2EH48@1|root,33AW7@2|Bacteria,2J921@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - YYD2_k127_4316792_2 536227.CcarbDRAFT_4129 6.78e-129 422.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,36E5F@31979|Clostridiaceae 186801|Clostridia C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate icd - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh YYD2_k127_4316792_7 1379698.RBG1_1C00001G0536 2.262e-36 145.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA YYD2_k127_4316792_5 1001585.MDS_1229 4.86e-68 243.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1YJRS@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P transporter MgtE mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N YYD2_k127_4316792_4 1379698.RBG1_1C00001G1327 7.726e-82 282.0 COG0382@1|root,COG0382@2|Bacteria,2NNVJ@2323|unclassified Bacteria 2|Bacteria H UbiA prenyltransferase family ubiA - - - - - - - - - - - UbiA YYD2_k127_4316792_9 1220582.RRU01S_26_01200 1.295e-14 85.0 COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2TT5I@28211|Alphaproteobacteria,4BCWB@82115|Rhizobiaceae 28211|Alphaproteobacteria I Diacylglycerol kinase catalytic domain (presumed) - - - - - - - - - - - - DAGK_cat YYD2_k127_4316792_10 518766.Rmar_0450 2.008e-06 57.0 28PR3@1|root,30SU9@2|Bacteria,4P9QM@976|Bacteroidetes,1FJHG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_4316792_3 1379698.RBG1_1C00001G0230 2.14e-99 343.0 COG2206@1|root,COG2206@2|Bacteria,2NPP4@2323|unclassified Bacteria 2|Bacteria T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD YYD2_k127_4316792_6 1379698.RBG1_1C00001G0231 2.097e-43 181.0 COG1413@1|root,COG1413@2|Bacteria,2NRMK@2323|unclassified Bacteria 2|Bacteria C HEAT repeats CP_0755 - - - - - - - - - - - HEAT_2,HEAT_PBS,Response_reg YYD2_k127_4316792_0 1379698.RBG1_1C00001G0637 1.014e-186 593.0 COG0677@1|root,COG0677@2|Bacteria,2NNQ1@2323|unclassified Bacteria 2|Bacteria M UDP binding domain - - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N YYD2_k127_4318837_14 1191523.MROS_0709 1.361e-16 93.0 COG4288@1|root,COG4288@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Amidase_2,Big_5,CHU_C,FlgD_ig,LTD YYD2_k127_4318837_6 1379698.RBG1_1C00001G1866 9.508e-101 345.0 COG2204@1|root,COG2204@2|Bacteria,2NQDH@2323|unclassified Bacteria 2|Bacteria T Sigma-54 interaction domain fhlA - - ko:K03413,ko:K13589 ko02020,ko02030,ko04112,map02020,map02030,map04112 M00506,M00512 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_4318837_2 555079.Toce_1819 9.308e-170 558.0 COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,42FKG@68295|Thermoanaerobacterales 186801|Clostridia J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 YYD2_k127_4318837_12 926560.KE387023_gene2874 3.578e-25 109.0 2EM7W@1|root,33EX0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4318837_7 561180.BIFGAL_03343 2.182e-64 238.0 COG0619@1|root,COG1129@1|root,COG0619@2|Bacteria,COG1129@2|Bacteria,2I2G4@201174|Actinobacteria,4CZJE@85004|Bifidobacteriales 201174|Actinobacteria GP ABC transporter, ATP-binding protein - - - ko:K16785,ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran,CbiQ YYD2_k127_4318837_0 1379698.RBG1_1C00001G1497 2.918e-183 585.0 COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS11880 Aminotran_5,GDC-P YYD2_k127_4318837_15 1123073.KB899241_gene2430 6.639e-07 59.0 COG4232@1|root,COG4232@2|Bacteria,1R2KR@1224|Proteobacteria,1T5SN@1236|Gammaproteobacteria,1XDEM@135614|Xanthomonadales 135614|Xanthomonadales CO Thioredoxin-like - - - - - - - - - - - - Thioredoxin_7 YYD2_k127_4318837_16 1191523.MROS_1631 5.09e-06 53.0 COG2260@1|root,COG2260@2|Bacteria 2|Bacteria J snoRNA binding - - - - - - - - - - - - DUF2007 YYD2_k127_4318837_4 1379698.RBG1_1C00001G1499 7.108e-151 489.0 COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P YYD2_k127_4318837_8 1220551.SCHR_01445 3.762e-46 169.0 COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,4GZ53@90964|Staphylococcaceae 91061|Bacilli E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H YYD2_k127_4318837_1 880073.Calab_3241 2.698e-182 582.0 COG0439@1|root,COG0439@2|Bacteria,2NNWM@2323|unclassified Bacteria 2|Bacteria I acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 YYD2_k127_4318837_11 1101195.Meth11DRAFT_2257 7.033e-26 109.0 COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,2VV31@28216|Betaproteobacteria,2KN8M@206350|Nitrosomonadales 206350|Nitrosomonadales P Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 YYD2_k127_4318837_10 886293.Sinac_7127 5.452e-31 134.0 COG0823@1|root,COG0823@2|Bacteria,2IZKS@203682|Planctomycetes 203682|Planctomycetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 YYD2_k127_4318837_13 1379698.RBG1_1C00001G0435 4.221e-23 111.0 COG1747@1|root,COG1747@2|Bacteria,2NP33@2323|unclassified Bacteria 2|Bacteria M methyltransferase greA - - - - - - - - - - - GreA_GreB,GreA_GreB_N,SprA_N YYD2_k127_4318837_3 1379698.RBG1_1C00001G1502 3.565e-164 525.0 COG2805@1|root,COG2805@2|Bacteria,2NP0T@2323|unclassified Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT-1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE YYD2_k127_4318837_9 1379698.RBG1_1C00001G1503 3.43e-40 154.0 COG0511@1|root,COG0511@2|Bacteria,2NPT1@2323|unclassified Bacteria 2|Bacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - 2.3.1.12,4.1.1.3 ko:K00627,ko:K01571,ko:K02160 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00307,M00376 R00209,R00217,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - iHN637.CLJU_RS20755 Biotin_lipoyl YYD2_k127_4318837_5 1379698.RBG1_1C00001G1504 4.803e-104 349.0 COG0006@1|root,COG0006@2|Bacteria,2NP41@2323|unclassified Bacteria 2|Bacteria E Creatinase/Prolidase N-terminal domain pepP - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 YYD2_k127_4319451_4 502025.Hoch_0762 5.504e-58 209.0 COG1409@1|root,COG1409@2|Bacteria,1N7CQ@1224|Proteobacteria,430CA@68525|delta/epsilon subdivisions,2WW6B@28221|Deltaproteobacteria,2YWTS@29|Myxococcales 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 YYD2_k127_4319451_1 1379698.RBG1_1C00001G1510 1.3e-155 504.0 COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria 2|Bacteria S Putative modulator of DNA gyrase tldE2 - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD YYD2_k127_4319451_0 1379698.RBG1_1C00001G1511 1.534e-202 640.0 COG0312@1|root,COG0312@2|Bacteria,2NPIS@2323|unclassified Bacteria 2|Bacteria S Putative modulator of DNA gyrase tldD2 - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD YYD2_k127_4319451_2 926549.KI421517_gene464 1.581e-128 417.0 COG0667@1|root,COG0667@2|Bacteria,4NEDK@976|Bacteroidetes,47N20@768503|Cytophagia 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red YYD2_k127_4319451_5 926550.CLDAP_26360 1.977e-49 194.0 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2G7I4@200795|Chloroflexi 200795|Chloroflexi UW Hep Hag repeat protein - - - - - - - - - - - - - YYD2_k127_4319451_9 589865.DaAHT2_1264 0.0005787 45.0 COG0316@1|root,COG0316@2|Bacteria,1N8FK@1224|Proteobacteria,42VBF@68525|delta/epsilon subdivisions,2WR7Y@28221|Deltaproteobacteria,2MKZ6@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the HesB IscA family - - - - - - - - - - - - Fe-S_biosyn YYD2_k127_4319451_3 1379698.RBG1_1C00001G1377 2.879e-112 391.0 COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase YYD2_k127_4319451_7 1379698.RBG1_1C00001G0763 1.597e-15 88.0 COG2885@1|root,COG5276@1|root,COG2885@2|Bacteria,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - - - - - - - - - - - Phenol_MetA_deg YYD2_k127_4319451_8 441769.ABFU01000135_gene3474 6.374e-11 66.0 2ERMT@1|root,33J79@2|Bacteria,1VKZE@1239|Firmicutes,4I01W@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - YYD2_k127_4319451_6 525367.HMPREF0556_11507 2.465e-26 108.0 2DPM9@1|root,332MQ@2|Bacteria,1VGFB@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - YYD2_k127_4321139_2 1379698.RBG1_1C00001G1194 3.771e-98 364.0 COG2911@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - 3.2.1.91 ko:K14194,ko:K19668 ko00500,ko01100,ko02020,ko05150,map00500,map01100,map02020,map05150 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CHU_C,DUF11,FlgD_ig,PKD,SdrD_B YYD2_k127_4321139_6 497964.CfE428DRAFT_5644 1.523e-34 151.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,46UMD@74201|Verrucomicrobia 2|Bacteria O Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_8 YYD2_k127_4321139_4 930169.B5T_00618 1.55e-69 245.0 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,1XHCF@135619|Oceanospirillales 135619|Oceanospirillales HJ alpha-L-glutamate ligase - - - - - - - - - - - - ATPgrasp_ST YYD2_k127_4321139_1 404589.Anae109_3474 2.05e-102 354.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,42U1I@68525|delta/epsilon subdivisions,2WQQV@28221|Deltaproteobacteria 28221|Deltaproteobacteria E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_core,Transglut_i_TM YYD2_k127_4321139_13 620914.JH621247_gene2959 8.704e-06 58.0 COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia,2YJ4Y@290174|Aquimarina 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_21,TPR_6,TPR_8 YYD2_k127_4321139_14 1121895.Q765_16645 2.712e-05 53.0 COG1629@1|root,COG1629@2|Bacteria,4NFW1@976|Bacteroidetes,1HYS9@117743|Flavobacteriia,2NSYI@237|Flavobacterium 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug YYD2_k127_4321139_5 1380387.JADM01000003_gene2330 1.127e-61 226.0 29HQP@1|root,30M4I@2|Bacteria,1RDRF@1224|Proteobacteria,1SNBJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF3541) - - - - - - - - - - - - DUF3541 YYD2_k127_4321139_12 991.IW20_17930 6.004e-08 65.0 COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria,4NJNB@976|Bacteroidetes,1I16M@117743|Flavobacteriia,2NVQU@237|Flavobacterium 976|Bacteroidetes M O-Antigen ligase - - - - - - - - - - - - TPR_2,TPR_8,Wzy_C YYD2_k127_4321139_7 661478.OP10G_1458 4.663e-32 136.0 COG0241@1|root,COG0279@1|root,COG0241@2|Bacteria,COG0279@2|Bacteria 2|Bacteria G D-glycero-D-manno-heptose 7-phosphate metabolic process gmhA - 3.1.3.82,3.1.3.83,5.3.1.28 ko:K02843,ko:K03271,ko:K03273 ko00540,ko01100,map00540,map01100 M00064,M00080 R05645,R05647,R09768,R09769,R09771 RC00017,RC00434 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - HupF_HypC,Hydrolase_like,SIS_2 YYD2_k127_4321139_3 517418.Ctha_0722 1.294e-73 255.0 COG1646@1|root,COG1646@2|Bacteria,1FEV5@1090|Chlorobi 1090|Chlorobi I PcrB family - - - ko:K07094 - - - - ko00000,ko01000 - - - PcrB YYD2_k127_4321139_0 1123371.ATXH01000014_gene1607 7.984e-235 754.0 COG0013@1|root,COG0013@2|Bacteria,2GH36@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD YYD2_k127_4321139_11 313628.LNTAR_20978 6.648e-09 65.0 COG2137@1|root,COG2137@2|Bacteria 2|Bacteria S regulation of DNA repair recX GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 ko:K03565,ko:K19002 ko00561,ko01100,map00561,map01100 - R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03400 - GT4 - RecX YYD2_k127_4321139_8 1121403.AUCV01000005_gene233 4.406e-17 92.0 COG0457@1|root,COG0457@2|Bacteria,1R64F@1224|Proteobacteria,42Q6D@68525|delta/epsilon subdivisions,2WKT0@28221|Deltaproteobacteria,2MHV1@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388 YYD2_k127_4326906_9 706587.Desti_5245 6.528e-41 151.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MQ8F@213462|Syntrophobacterales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 YYD2_k127_4326906_7 1379698.RBG1_1C00001G1598 2.078e-44 162.0 COG0051@1|root,COG0051@2|Bacteria,2NPJY@2323|unclassified Bacteria 2|Bacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 YYD2_k127_4326906_3 1379698.RBG1_1C00001G1596 8.697e-67 234.0 COG0087@1|root,COG0087@2|Bacteria,2NPAI@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 YYD2_k127_4326906_5 1297581.H919_09051 1.169e-60 215.0 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4HB01@91061|Bacilli,21WMU@150247|Anoxybacillus 91061|Bacilli J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 YYD2_k127_4326906_13 1265505.ATUG01000001_gene3707 4.418e-16 81.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,42V3Y@68525|delta/epsilon subdivisions,2WRMX@28221|Deltaproteobacteria,2MKJ3@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 YYD2_k127_4326906_0 335543.Sfum_1558 2.727e-116 380.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2MR4Z@213462|Syntrophobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C YYD2_k127_4326906_8 1379698.RBG1_1C00001G1592 2.051e-43 159.0 COG0185@1|root,COG0185@2|Bacteria,2NPIV@2323|unclassified Bacteria 2|Bacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 YYD2_k127_4326906_12 557599.MKAN_19660 2.177e-24 108.0 COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,238NP@1762|Mycobacteriaceae 201174|Actinobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 YYD2_k127_4326906_1 1379698.RBG1_1C00001G1590 3.577e-93 314.0 COG0092@1|root,COG0092@2|Bacteria,2NP6J@2323|unclassified Bacteria 2|Bacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C YYD2_k127_4326906_4 221288.JH992901_gene949 7.771e-66 226.0 COG0197@1|root,COG0197@2|Bacteria,1G55B@1117|Cyanobacteria,1JIH0@1189|Stigonemataceae 1117|Cyanobacteria J Ribosomal protein L16p/L10e rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 YYD2_k127_4326906_14 1379698.RBG1_1C00001G1588 7.432e-15 77.0 COG0255@1|root,COG0255@2|Bacteria,2NQ49@2323|unclassified Bacteria 2|Bacteria J Ribosomal L29 protein rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 YYD2_k127_4326906_11 518766.Rmar_0851 1.634e-27 113.0 COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,1FJGB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 YYD2_k127_4326906_6 1379698.RBG1_1C00001G1586 1.078e-51 188.0 COG0093@1|root,COG0093@2|Bacteria,2NPCS@2323|unclassified Bacteria 2|Bacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 YYD2_k127_4326906_10 1408254.T458_24835 1.89e-28 117.0 COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,4HKH9@91061|Bacilli,26XQC@186822|Paenibacillaceae 91061|Bacilli J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 YYD2_k127_4326906_2 1121422.AUMW01000023_gene2774 2.569e-72 248.0 COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,2603I@186807|Peptococcaceae 186801|Clostridia J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C YYD2_k127_4329665_12 1535422.ND16A_3455 0.0005154 49.0 COG4733@1|root,COG4886@1|root,COG4932@1|root,COG4733@2|Bacteria,COG4886@2|Bacteria,COG4932@2|Bacteria,1PIDH@1224|Proteobacteria,1SXX5@1236|Gammaproteobacteria,2Q7Y4@267889|Colwelliaceae 1236|Gammaproteobacteria M CarboxypepD_reg-like domain - - - - - - - - - - - - CarboxypepD_reg YYD2_k127_4329665_1 1379698.RBG1_1C00001G0987 2.931e-163 527.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02481,ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_4329665_2 945713.IALB_2034 2.104e-158 514.0 COG0733@1|root,COG0733@2|Bacteria 2|Bacteria S neurotransmitter:sodium symporter activity - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF YYD2_k127_4329665_4 1123070.KB899250_gene465 2.409e-67 238.0 COG1968@1|root,COG1968@2|Bacteria,46SP6@74201|Verrucomicrobia,2IURU@203494|Verrucomicrobiae 203494|Verrucomicrobiae V Bacitracin resistance protein BacA uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA YYD2_k127_4329665_7 1007096.BAGW01000004_gene1666 6.826e-38 160.0 COG0241@1|root,COG0241@2|Bacteria,1UXGW@1239|Firmicutes,25MSQ@186801|Clostridia,2N8NW@216572|Oscillospiraceae 186801|Clostridia E Polynucleotide kinase 3 phosphatase - - - - - - - - - - - - Hydrolase_like YYD2_k127_4329665_3 760568.Desku_0258 4.8e-103 344.0 COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,2617J@186807|Peptococcaceae 186801|Clostridia C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM YYD2_k127_4329665_0 1379698.RBG1_1C00001G1445 3.363e-265 845.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NQSG@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - BSP,Bac_surface_Ag,PD40,Peptidase_MA_2 YYD2_k127_4329665_9 479434.Sthe_1246 1.544e-26 123.0 COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2G5NM@200795|Chloroflexi,27Z13@189775|Thermomicrobia 189775|Thermomicrobia KLT PQQ-like domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PQQ_3,Pkinase YYD2_k127_4329665_6 1379698.RBG1_1C00001G1443 1.073e-51 207.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - DUF4132,DUF4145,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Pro_isomerase YYD2_k127_4329665_10 688269.Theth_0014 2.849e-20 96.0 COG0071@1|root,COG0071@2|Bacteria,2GDCG@200918|Thermotogae 200918|Thermotogae O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 YYD2_k127_4329665_5 338966.Ppro_0013 3.777e-62 225.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,43T7R@69541|Desulfuromonadales 28221|Deltaproteobacteria O heat shock protein DnaJ domain protein - - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C YYD2_k127_4329665_11 97138.C820_00289 1.55e-12 69.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,36DF4@31979|Clostridiaceae 186801|Clostridia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N YYD2_k127_4435594_0 269797.Mbar_A0261 2.045e-49 186.0 COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota,2N91Y@224756|Methanomicrobia 224756|Methanomicrobia O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH YYD2_k127_4435594_1 1220534.B655_1754 1.851e-41 159.0 COG3467@1|root,arCOG00520@2157|Archaea,2Y26T@28890|Euryarchaeota,23PV6@183925|Methanobacteria 183925|Methanobacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 YYD2_k127_4474568_38 1242864.D187_006087 0.0002688 47.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2YVM8@29|Myxococcales 28221|Deltaproteobacteria O peptidylprolyl isomerase nifM - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 YYD2_k127_4474568_29 468059.AUHA01000002_gene787 5.207e-10 63.0 2E77J@1|root,331RB@2|Bacteria,4NZES@976|Bacteroidetes,1IUK7@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_4474568_25 404380.Gbem_3509 2.853e-17 91.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,42QTI@68525|delta/epsilon subdivisions,2WMRH@28221|Deltaproteobacteria,43SYN@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase YYD2_k127_4474568_1 1519464.HY22_07040 1.079e-193 619.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1FEF9@1090|Chlorobi 1090|Chlorobi C electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO YYD2_k127_4474568_34 264199.stu0997 3.742e-05 53.0 COG1393@1|root,COG1393@2|Bacteria,1V3QC@1239|Firmicutes,4HH0I@91061|Bacilli 91061|Bacilli K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress spxA - - ko:K16509 - - - - ko00000 - - - ArsC YYD2_k127_4474568_9 1379698.RBG1_1C00001G0810 4.192e-67 234.0 COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria 2|Bacteria S Methyltransferase domain yrrM - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 YYD2_k127_4474568_26 530564.Psta_2904 1.093e-16 83.0 COG2146@1|root,COG2146@2|Bacteria,2J0FX@203682|Planctomycetes 203682|Planctomycetes P COG2146 Ferredoxin subunits of nitrite reductase and - - 1.7.1.15 ko:K00363,ko:K05710 ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske YYD2_k127_4474568_2 1379698.RBG1_1C00001G1882 1.321e-167 554.0 COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm YYD2_k127_4474568_8 1379698.RBG1_1C00001G1880 1.535e-69 246.0 COG0761@1|root,COG0761@2|Bacteria,2NP7K@2323|unclassified Bacteria 2|Bacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - iIT341.HP0400,iLJ478.TM1444 LYTB,S1 YYD2_k127_4474568_5 1382306.JNIM01000001_gene701 1.248e-93 316.0 COG0320@1|root,COG0320@2|Bacteria,2G5MH@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM YYD2_k127_4474568_14 278963.ATWD01000002_gene856 5.791e-47 176.0 COG0311@1|root,COG0311@2|Bacteria,3Y4GN@57723|Acidobacteria,2JJ3V@204432|Acidobacteriia 204432|Acidobacteriia H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SNO YYD2_k127_4474568_3 1379698.RBG1_1C00001G1877 7.678e-123 400.0 COG0214@1|root,COG0214@2|Bacteria,2NNZ6@2323|unclassified Bacteria 2|Bacteria H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively pdxS GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ YYD2_k127_4474568_24 349161.Dred_2964 1.935e-26 113.0 COG1959@1|root,COG1959@2|Bacteria,1VA5B@1239|Firmicutes,24JMN@186801|Clostridia 186801|Clostridia K transcriptional regulator, Rrf2 family - - - - - - - - - - - - Rrf2 YYD2_k127_4474568_21 1379698.RBG1_1C00001G0095 6.082e-33 131.0 COG0316@1|root,COG0316@2|Bacteria,2NPZK@2323|unclassified Bacteria 2|Bacteria S Belongs to the HesB IscA family ycf57 GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:1901564 - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn YYD2_k127_4474568_23 1379698.RBG1_1C00001G0093 4.316e-30 123.0 COG0633@1|root,COG0633@2|Bacteria 2|Bacteria C Ferredoxin fdx GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 - ko:K04755 - - - - ko00000 - - - Fer2 YYD2_k127_4474568_33 1502770.JQMG01000001_gene15 3.266e-05 55.0 COG2165@1|root,COG2165@2|Bacteria,1N0UD@1224|Proteobacteria,2W2VV@28216|Betaproteobacteria 28216|Betaproteobacteria NU general secretion pathway protein - - - - - - - - - - - - N_methyl YYD2_k127_4474568_37 765912.Thimo_0046 0.0001868 53.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales 135613|Chromatiales U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG YYD2_k127_4474568_35 1123377.AUIV01000012_gene770 6.195e-05 55.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S69B@1236|Gammaproteobacteria,1X6DG@135614|Xanthomonadales 135614|Xanthomonadales NU General secretion pathway protein xpsG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG YYD2_k127_4474568_31 1131814.JAFO01000001_gene1828 2.24e-06 58.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2U7GY@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU general secretion pathway protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG YYD2_k127_4474568_4 1379698.RBG1_1C00001G0675 5.075e-95 331.0 COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria 2|Bacteria E Saccharopine dehydrogenase C-terminal domain lysDH - 1.4.1.18 ko:K19064 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R00446,R02317 RC00062,RC00694 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP YYD2_k127_4474568_36 189426.PODO_16020 8.968e-05 50.0 COG0642@1|root,COG2205@2|Bacteria,1VS9T@1239|Firmicutes,4IS7H@91061|Bacilli,26UAF@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA YYD2_k127_4474568_20 344747.PM8797T_29932 2.8e-33 149.0 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,2IYCE@203682|Planctomycetes 203682|Planctomycetes S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA YYD2_k127_4474568_6 1379698.RBG1_1C00001G1639 6.004e-92 312.0 COG0142@1|root,COG0142@2|Bacteria,2NP7G@2323|unclassified Bacteria 2|Bacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.30,2.5.1.90 ko:K00805,ko:K02523 ko00900,ko01110,map00900,map01110 - R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt YYD2_k127_4474568_18 1121904.ARBP01000017_gene5093 3.777e-35 153.0 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,47V4E@768503|Cytophagia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Fn3_assoc,Metallophos,PA14 YYD2_k127_4474568_11 1366050.N234_12310 1.741e-51 194.0 COG2267@1|root,COG2267@2|Bacteria,1R72P@1224|Proteobacteria,2WH24@28216|Betaproteobacteria,1K5AI@119060|Burkholderiaceae 28216|Betaproteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6 YYD2_k127_4474568_19 1380355.JNIJ01000020_gene3780 1.145e-34 136.0 COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,3JYUE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1428) - - - - - - - - - - - - DUF1428 YYD2_k127_4474568_15 479434.Sthe_2969 9.973e-40 158.0 COG0262@1|root,COG0262@2|Bacteria,2G8M0@200795|Chloroflexi 200795|Chloroflexi H PFAM bifunctional deaminase-reductase domain protein - - - - - - - - - - - - RibD_C YYD2_k127_4474568_17 290397.Adeh_2244 6.069e-37 144.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria 1224|Proteobacteria S Doxx family - - - ko:K15977 - - - - ko00000 - - - DoxX YYD2_k127_4474568_12 1210884.HG799471_gene14625 1.325e-48 179.0 COG3832@1|root,COG3832@2|Bacteria,2J16I@203682|Planctomycetes 203682|Planctomycetes S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 YYD2_k127_4474568_13 717785.HYPMC_3864 2.093e-47 173.0 COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,3N8NC@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria K Bacterial regulatory protein, arsR family - - - - - - - - - - - - HTH_20 YYD2_k127_4474568_32 479434.Sthe_1753 2.242e-06 55.0 COG5615@1|root,COG5615@2|Bacteria,2GBBE@200795|Chloroflexi,27YNG@189775|Thermomicrobia 189775|Thermomicrobia S Domain of unknown function (DUF4149) - - - - - - - - - - - - CopD YYD2_k127_4474568_0 1379698.RBG1_1C00001G0312 5.324e-215 674.0 COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria 2|Bacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind YYD2_k127_4474568_22 1379698.RBG1_1C00001G0311 6.734e-32 129.0 COG0799@1|root,COG0799@2|Bacteria,2NPYI@2323|unclassified Bacteria 2|Bacteria S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RsfS YYD2_k127_4474568_10 1121121.KB894301_gene2208 1.863e-62 224.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H9V5@91061|Bacilli,26RIB@186822|Paenibacillaceae 91061|Bacilli M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase YYD2_k127_4474568_16 653733.Selin_2220 1.048e-37 144.0 COG0853@1|root,COG0853@2|Bacteria 2|Bacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0139,iYL1228.KPN_00139 Asp_decarbox YYD2_k127_4474568_30 262768.PAM_476 1.043e-06 57.0 COG1051@1|root,COG1051@2|Bacteria,3WV0W@544448|Tenericutes 544448|Tenericutes F NUDIX domain mutT - - - - - - - - - - - NUDIX YYD2_k127_4474568_7 944480.ATUV01000001_gene790 9.95e-83 282.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2WJ19@28221|Deltaproteobacteria,2M6SN@213113|Desulfurellales 28221|Deltaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase YYD2_k127_4520835_1 1379698.RBG1_1C00001G1742 5.911e-160 512.0 COG2805@1|root,COG2805@2|Bacteria,2NNR7@2323|unclassified Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE YYD2_k127_4520835_0 944479.JQLX01000010_gene642 3.648e-175 565.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M6BJ@213113|Desulfurellales 28221|Deltaproteobacteria NU Type II secretion system protein E pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding YYD2_k127_4520835_3 1379698.RBG1_1C00001G1744 5.292e-64 222.0 COG2018@1|root,COG2018@2|Bacteria,2NQXH@2323|unclassified Bacteria 2|Bacteria S Roadblock/LC7 domain mglB - - - - - - - - - - - Robl_LC7 YYD2_k127_4520835_2 1379698.RBG1_1C00001G1745 8.173e-85 292.0 COG1100@1|root,COG1100@2|Bacteria,2NPDD@2323|unclassified Bacteria 2|Bacteria K - Catabolite gene activator and regulatory subunit of cAMP-dependent protein mglA GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - ko:K06883 - - - - ko00000 - - - Arf,DUF697,MMR_HSR1 YYD2_k127_4520835_5 1379698.RBG1_1C00001G1746 2.364e-37 144.0 COG2018@1|root,COG2018@2|Bacteria,2NRUR@2323|unclassified Bacteria 2|Bacteria S Roadblock/LC7 domain - - - ko:K07131 - - - - ko00000 - - - Robl_LC7 YYD2_k127_4520835_4 1379698.RBG1_1C00001G1748 9.819e-49 185.0 COG0457@1|root,COG0457@2|Bacteria,2NS1B@2323|unclassified Bacteria 2|Bacteria M Tetratricopeptide repeat - - - - - - - - - - - - - YYD2_k127_4520835_6 1379698.RBG1_1C00001G1750 6.913e-23 106.0 COG0457@1|root,COG0457@2|Bacteria,2NRMR@2323|unclassified Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - DUF4388 YYD2_k127_4524154_9 1266925.JHVX01000001_gene2468 2.307e-14 75.0 2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,2W8JG@28216|Betaproteobacteria,373T2@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_4524154_10 1382359.JIAL01000001_gene198 1.761e-11 68.0 2E34G@1|root,32Y4J@2|Bacteria,3Y5JB@57723|Acidobacteria,2JJW7@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - YYD2_k127_4524154_8 304371.MCP_1737 4.521e-22 100.0 COG5646@1|root,arCOG09457@2157|Archaea,2Y1ED@28890|Euryarchaeota 28890|Euryarchaeota S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 YYD2_k127_4524154_7 868131.MSWAN_2301 5.497e-28 119.0 COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23P3X@183925|Methanobacteria 183925|Methanobacteria V DUF35 OB-fold domain, acyl-CoA-associated - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc YYD2_k127_4524154_2 456442.Mboo_0156 1.224e-122 406.0 COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia 224756|Methanomicrobia I PFAM Thiolase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAF692.Mbar_A0550 Thiolase_C,Thiolase_N YYD2_k127_4524154_1 339860.Msp_0117 1.151e-132 431.0 COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23NSI@183925|Methanobacteria 183925|Methanobacteria I Belongs to the UPF0219 family - - 2.3.3.10 ko:K01641 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000 - - - ACP_syn_III_C,HMG_CoA_synt_N YYD2_k127_4524154_11 1117108.PAALTS15_07454 1.388e-10 70.0 COG0791@1|root,COG0791@2|Bacteria,1TP24@1239|Firmicutes,4HA77@91061|Bacilli,26XBX@186822|Paenibacillaceae 91061|Bacilli M NlpC/P60 family - - - ko:K19224,ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - CBM50 - Cu_amine_oxidN1,LysM,NLPC_P60 YYD2_k127_4524154_6 997346.HMPREF9374_3758 1.117e-32 133.0 COG1762@1|root,COG1762@2|Bacteria,1UK64@1239|Firmicutes,4ITII@91061|Bacilli 91061|Bacilli GT Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - - - - - - - - - - PTS_EIIA_2 YYD2_k127_4524154_5 945713.IALB_3017 9.514e-35 145.0 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination - - - - - - - - - - - - EamA YYD2_k127_4524154_4 1278309.KB907099_gene2766 1.875e-35 144.0 arCOG09454@1|root,30G4A@2|Bacteria,1N61J@1224|Proteobacteria,1SRHG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_4524154_0 1313301.AUGC01000016_gene837 1.755e-308 966.0 COG0542@1|root,COG0542@2|Bacteria,4NGEM@976|Bacteroidetes 976|Bacteroidetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N YYD2_k127_4565679_2 517418.Ctha_1151 4.108e-71 246.0 COG0068@1|root,COG0068@2|Bacteria,1FDST@1090|Chlorobi 1090|Chlorobi O Belongs to the carbamoyltransferase HypF family - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF YYD2_k127_4565679_3 1408428.JNJP01000024_gene3775 9.456e-71 245.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2M883@213115|Desulfovibrionales 28221|Deltaproteobacteria KO Hydrogenase accessory protein HypB hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW YYD2_k127_4565679_8 1304875.JAFZ01000001_gene1638 6.331e-22 99.0 COG0375@1|root,COG0375@2|Bacteria,3TBGH@508458|Synergistetes 508458|Synergistetes C Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA YYD2_k127_4565679_6 1379698.RBG1_1C00001G1194 1.97e-43 179.0 COG2911@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - 3.2.1.91 ko:K14194,ko:K19668 ko00500,ko01100,ko02020,ko05150,map00500,map01100,map02020,map05150 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CHU_C,DUF11,FlgD_ig,PKD,SdrD_B YYD2_k127_4565679_5 589865.DaAHT2_0011 1.598e-47 178.0 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2MKHV@213118|Desulfobacterales 28221|Deltaproteobacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase YYD2_k127_4565679_1 243233.MCA2183 3.595e-76 259.0 COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,1S3N1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 YYD2_k127_4565679_0 880073.Calab_3769 2.795e-250 790.0 COG1770@1|root,COG1770@2|Bacteria,2NNMF@2323|unclassified Bacteria 2|Bacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N YYD2_k127_4565679_4 1032480.MLP_26610 7.471e-64 228.0 COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4DQCW@85009|Propionibacteriales 201174|Actinobacteria GK ROK family ppgK - 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK YYD2_k127_4565679_7 717231.Flexsi_2157 8.209e-30 124.0 COG1528@1|root,COG1528@2|Bacteria,2GFDZ@200930|Deferribacteres 200930|Deferribacteres C Iron-storage protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin YYD2_k127_45706_1 880071.Fleli_3516 1.136e-53 194.0 COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,47JUC@768503|Cytophagia 976|Bacteroidetes I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01692,ko:K01715 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 YYD2_k127_45706_3 697329.Rumal_2962 5.769e-08 63.0 COG1670@1|root,COG1670@2|Bacteria,1V4F3@1239|Firmicutes,24EZ6@186801|Clostridia,3WM79@541000|Ruminococcaceae 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 YYD2_k127_45706_0 1379698.RBG1_1C00001G0527 1.041e-168 539.0 COG1960@1|root,COG1960@2|Bacteria,2NNXA@2323|unclassified Bacteria 2|Bacteria I Acyl-CoA dehydrogenase, C-terminal domain B4168_2380 - 1.3.99.32 ko:K16173 ko00362,ko01120,map00362,map01120 - R05579 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N YYD2_k127_45706_2 1267534.KB906754_gene3483 2.747e-08 58.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K12287 - - - - ko00000,ko02044 - - - DUF11,VCBS YYD2_k127_4623707_4 504487.JCM19302_2911 6.512e-16 84.0 COG3832@1|root,COG3832@2|Bacteria,4NPKI@976|Bacteroidetes,1I28I@117743|Flavobacteriia 976|Bacteroidetes S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 YYD2_k127_4623707_1 1379698.RBG1_1C00001G1704 5.714e-70 241.0 COG1595@1|root,COG1595@2|Bacteria,2NPRC@2323|unclassified Bacteria 2|Bacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD2_k127_4623707_5 485913.Krac_4641 7.835e-12 76.0 COG3595@1|root,COG3595@2|Bacteria,2G9KA@200795|Chloroflexi 200795|Chloroflexi S Putative adhesin - - - - - - - - - - - - DUF4097 YYD2_k127_4623707_2 861299.J421_3911 1.645e-24 116.0 COG4758@1|root,COG4758@2|Bacteria 2|Bacteria KT membrane yvqF - - ko:K11622 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2154 YYD2_k127_4623707_0 880073.Calab_0984 2.955e-95 329.0 COG0265@1|root,COG0265@2|Bacteria,2NQK9@2323|unclassified Bacteria 2|Bacteria O Trypsin degQ - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD2_k127_4623707_3 443144.GM21_0228 5.96e-21 106.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43UDA@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM peptidase S1 and S6, chymotrypsin Hap degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD2_k127_4639063_2 1121957.ATVL01000008_gene4553 2.169e-26 126.0 COG5295@1|root,COG5295@2|Bacteria,4NKG1@976|Bacteroidetes,47NK6@768503|Cytophagia 976|Bacteroidetes MUW domain, Protein - - - - - - - - - - - - Peptidase_S74 YYD2_k127_4639063_4 1379698.RBG1_1C00001G0237 5.165e-11 76.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,LVIVD YYD2_k127_4639063_0 926550.CLDAP_14520 1.888e-82 284.0 COG0111@1|root,COG0111@2|Bacteria 2|Bacteria EH 4-phosphoerythronate dehydrogenase activity - - 1.1.1.399,1.1.1.95,1.17.1.9 ko:K00058,ko:K00122 ko00260,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00519,R01513 RC00031,RC02796 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C YYD2_k127_4639063_6 635013.TherJR_2859 2.415e-08 69.0 COG4412@1|root,COG5184@1|root,COG5492@1|root,COG4412@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1TS5I@1239|Firmicutes,24A8Z@186801|Clostridia,261X1@186807|Peptococcaceae 186801|Clostridia DZ regulator of chromosome condensation, RCC1 - - - - - - - - - - - - Beta_helix,Big_2,CHB_HEX_C_1,CW_binding_2,Cu_amine_oxidN1,RCC1,RCC1_2 YYD2_k127_4639063_3 1121930.AQXG01000001_gene1125 1.463e-19 106.0 COG0737@1|root,COG1506@1|root,COG0737@2|Bacteria,COG1506@2|Bacteria,4NQQD@976|Bacteroidetes 976|Bacteroidetes E Lamin Tail Domain - - - - - - - - - - - - Calx-beta,LTD YYD2_k127_4639063_1 1192034.CAP_8119 1.756e-50 198.0 COG5184@1|root,COG5184@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria,2YV9Z@29|Myxococcales 28221|Deltaproteobacteria DZ Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 YYD2_k127_4639063_7 1123020.AUIE01000041_gene3194 6.586e-05 51.0 2DN7J@1|root,32VZC@2|Bacteria,1N6CR@1224|Proteobacteria,1SAGW@1236|Gammaproteobacteria,1YGRC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ YYD2_k127_4656464_12 1341181.FLJC2902T_14440 5.573e-38 145.0 COG3631@1|root,COG3631@2|Bacteria,4NTMZ@976|Bacteroidetes,1I61G@117743|Flavobacteriia,2NWYB@237|Flavobacterium 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 YYD2_k127_4656464_0 522306.CAP2UW1_4252 9.559e-165 533.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2VXAW@28216|Betaproteobacteria 28216|Betaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM YYD2_k127_4656464_11 1499967.BAYZ01000182_gene4428 8.008e-41 154.0 COG0599@1|root,COG0599@2|Bacteria,2NRHA@2323|unclassified Bacteria 2|Bacteria O Carboxymuconolactone decarboxylase family rnhA - 3.1.26.4,4.1.1.44 ko:K01607,ko:K03469 ko00362,ko01100,ko01120,ko01220,ko03030,map00362,map01100,map01120,map01220,map03030 - R03470 RC00938 ko00000,ko00001,ko01000,ko03032 - - - CMD YYD2_k127_4656464_18 102125.Xen7305DRAFT_00054230 5.631e-05 55.0 COG2931@1|root,COG2931@2|Bacteria,1GQMR@1117|Cyanobacteria,3VMWP@52604|Pleurocapsales 2|Bacteria Q PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Beta_helix,FG-GAP,HCBP_related,HemolysinCabind YYD2_k127_4656464_5 1379698.RBG1_1C00001G0179 1.327e-82 295.0 COG0065@1|root,COG0065@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity - - 4.2.1.33,4.2.1.35,4.2.1.36 ko:K01703,ko:K01705 ko00290,ko00300,ko00660,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00966,map01100,map01110,map01120,map01130,map01210,map01230 M00030,M00432,M00433,M00535 R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C YYD2_k127_4656464_8 1379698.RBG1_1C00001G0180 9.227e-52 188.0 COG0537@1|root,COG0537@2|Bacteria,2NPE0@2323|unclassified Bacteria 2|Bacteria FG HIT domain hit GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - HIT YYD2_k127_4656464_6 457570.Nther_2188 7.374e-81 292.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 YYD2_k127_4656464_1 1379698.RBG1_1C00001G0178 4.947e-115 387.0 COG2265@1|root,COG2265@2|Bacteria,2NNWX@2323|unclassified Bacteria 2|Bacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr YYD2_k127_4656464_7 234267.Acid_7868 1.791e-57 211.0 COG1230@1|root,COG1230@2|Bacteria,3Y32W@57723|Acidobacteria 57723|Acidobacteria P Cation efflux family - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux YYD2_k127_4656464_4 269799.Gmet_1153 1.075e-87 305.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WKVE@28221|Deltaproteobacteria,43S28@69541|Desulfuromonadales 28221|Deltaproteobacteria P CBS domain containing protein - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 YYD2_k127_4656464_3 56780.SYN_03628 9.582e-99 330.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MQ6Z@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 YYD2_k127_4656464_17 1265313.HRUBRA_00444 3.881e-07 63.0 COG3633@1|root,COG3633@2|Bacteria,1MXE1@1224|Proteobacteria,1RP9B@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) sstT GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 - ko:K07862 - - - - ko00000,ko02000 2.A.23.4 - iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iYL1228.KPN_03517,iZ_1308.Z4442 SDF YYD2_k127_4656464_16 278957.ABEA03000120_gene1234 6.352e-11 68.0 COG5652@1|root,COG5652@2|Bacteria,46WK5@74201|Verrucomicrobia,3K8DM@414999|Opitutae 414999|Opitutae S VanZ like family - - - - - - - - - - - - VanZ YYD2_k127_4656464_13 1379698.RBG1_1C00001G0593 4.043e-21 111.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,Cadherin_3,DUF11,FlgD_ig YYD2_k127_4656464_14 1191523.MROS_2048 3.526e-20 103.0 COG0737@1|root,COG3303@1|root,COG0737@2|Bacteria,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1,SBP_bac_8,SLH YYD2_k127_4656464_9 502025.Hoch_5906 2.905e-46 179.0 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,43AG6@68525|delta/epsilon subdivisions,2X63V@28221|Deltaproteobacteria,2Z38Y@29|Myxococcales 28221|Deltaproteobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090 - - - - ko00000,ko01000 - - - PP2C_2 YYD2_k127_4656464_15 1379270.AUXF01000004_gene2922 3.55e-19 91.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase YYD2_k127_4656464_2 1379698.RBG1_1C00001G1218 6.477e-104 373.0 COG0515@1|root,COG0515@2|Bacteria,2NQWH@2323|unclassified Bacteria 2|Bacteria KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase,TPR_8 YYD2_k127_4656464_10 518766.Rmar_0288 9.269e-42 162.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,4NI98@976|Bacteroidetes 976|Bacteroidetes KT Serine phosphatase RsbU regulator of sigma subunit - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE YYD2_k127_4660152_0 1191523.MROS_2740 2.267e-137 445.0 COG3185@1|root,COG3185@2|Bacteria 2|Bacteria E 4-Hydroxyphenylpyruvate dioxygenase - - - - - - - - - - - - AtuA YYD2_k127_4660152_1 1379698.RBG1_1C00001G0733 9.13e-54 208.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4672099_12 1379698.RBG1_1C00001G0606 7.3e-26 111.0 COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria 2|Bacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN678.aspS,iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon YYD2_k127_4672099_2 1379698.RBG1_1C00001G1659 6.889e-126 422.0 COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria 2|Bacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 YYD2_k127_4672099_10 1379698.RBG1_1C00001G1658 1.048e-32 130.0 COG0718@1|root,COG0718@2|Bacteria,2NPUK@2323|unclassified Bacteria 2|Bacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd YYD2_k127_4672099_4 446469.Sked_04720 9.089e-73 250.0 COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria 201174|Actinobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 YYD2_k127_4672099_1 471852.Tcur_2047 3.225e-146 477.0 COG1249@1|root,COG1249@2|Bacteria,2GPG1@201174|Actinobacteria,4EI74@85012|Streptosporangiales 201174|Actinobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain sthA - 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim YYD2_k127_4672099_5 880073.Calab_3299 1.445e-68 244.0 COG2067@1|root,COG2067@2|Bacteria,2NRA4@2323|unclassified Bacteria 2|Bacteria I PFAM Uncharacterised protein family (UPF0164) - - - - - - - - - - - - UPF0164 YYD2_k127_4672099_8 880073.Calab_3298 6.5e-62 242.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family ebh - - - - - - - - - - - DUF1611,Inhibitor_I9,Peptidase_S8,SLH YYD2_k127_4672099_3 945713.IALB_2907 6.898e-119 416.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD2_k127_4672099_11 580327.Tthe_2127 1.45e-30 134.0 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,42G7T@68295|Thermoanaerobacterales 186801|Clostridia S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind YYD2_k127_4672099_6 1499967.BAYZ01000017_gene6227 4.396e-67 249.0 COG4191@1|root,COG4191@2|Bacteria,2NP7Y@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF,HAMP,HATPase_c,HisKA YYD2_k127_4672099_14 518766.Rmar_1797 3.54e-21 97.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1FJ5I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T Bacterial regulatory protein, Fis family ntrX - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_4672099_16 1410670.JHXF01000012_gene2090 2.471e-14 77.0 COG0745@1|root,COG0745@2|Bacteria,1TPU2@1239|Firmicutes,24B71@186801|Clostridia,3WGHT@541000|Ruminococcaceae 186801|Clostridia T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C YYD2_k127_4672099_13 667014.Thein_1582 2.227e-21 109.0 COG2204@1|root,COG2204@2|Bacteria,2GI6F@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg YYD2_k127_4672099_9 1379698.RBG1_1C00001G0287 6.756e-43 178.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 YYD2_k127_4672099_7 1379698.RBG1_1C00001G0135 1.361e-63 226.0 COG0461@1|root,COG0461@2|Bacteria,2NPFJ@2323|unclassified Bacteria 2|Bacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran YYD2_k127_4672099_15 553385.JEMF01000058_gene249 6.448e-18 90.0 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,1XKU7@135619|Oceanospirillales 135619|Oceanospirillales I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS YYD2_k127_4672099_0 289376.THEYE_A0131 4.189e-241 763.0 COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD YYD2_k127_4691290_0 1379698.RBG1_1C00001G0646 4.873e-249 781.0 COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria 2|Bacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C YYD2_k127_4691290_1 1379698.RBG1_1C00001G0222 1.354e-132 441.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria 2|Bacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N YYD2_k127_4698218_1 357808.RoseRS_2711 2.255e-55 198.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,2G64U@200795|Chloroflexi,374ZG@32061|Chloroflexia 32061|Chloroflexia P YidE YbjL duplication domain protein - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C YYD2_k127_4698218_0 340099.Teth39_1216 7.441e-120 395.0 COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,42FDK@68295|Thermoanaerobacterales 186801|Clostridia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06430 GcpE YYD2_k127_4702132_1 401053.AciPR4_0327 3.837e-23 103.0 COG0501@1|root,COG0501@2|Bacteria,3Y2PP@57723|Acidobacteria,2JI24@204432|Acidobacteriia 204432|Acidobacteriia O Peptidase M48 - - - - - - - - - - - - Peptidase_M48,Peptidase_M48_N YYD2_k127_4702132_0 1379698.RBG1_1C00001G0290 5.419e-81 300.0 COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 YYD2_k127_4726001_1 1179773.BN6_67460 0.000786 45.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4DYU4@85010|Pseudonocardiales 201174|Actinobacteria EV WD40-like Beta Propeller Repeat - - - - - - - - - - - - Beta-lactamase,PD40,Peptidase_S9 YYD2_k127_4726001_0 665571.STHERM_c16630 0.0 1076.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2J5QV@203691|Spirochaetes 203691|Spirochaetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C YYD2_k127_4754223_0 1177594.MIC448_2490003 6.441e-32 135.0 COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4FKF8@85023|Microbacteriaceae 201174|Actinobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family tsnR - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind YYD2_k127_4758989_6 1379698.RBG1_1C00001G0971 1.839e-17 83.0 COG0152@1|root,COG0152@2|Bacteria,2NP0V@2323|unclassified Bacteria 2|Bacteria F SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 - - - SAICAR_synt YYD2_k127_4758989_3 518766.Rmar_1872 1.046e-52 195.0 COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1FITI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N YYD2_k127_4758989_0 1304885.AUEY01000058_gene2321 9.124e-167 537.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MIIZ@213118|Desulfobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey YYD2_k127_4758989_5 903818.KI912268_gene2872 1.826e-20 99.0 COG1011@1|root,COG1011@2|Bacteria,3Y56D@57723|Acidobacteria 57723|Acidobacteria S HAD-superfamily hydrolase, subfamily IA, variant 3 - - - ko:K07025 - - - - ko00000 - - - HAD_2 YYD2_k127_4758989_4 526227.Mesil_2652 7.173e-37 149.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity bioH - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 YYD2_k127_4758989_2 246194.CHY_1102 7.969e-147 480.0 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,42EXF@68295|Thermoanaerobacterales 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase YYD2_k127_4758989_1 1379698.RBG1_1C00001G0965 2.978e-165 526.0 COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria 2|Bacteria E glutamine synthetase glnA2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N YYD2_k127_4775225_7 1121472.AQWN01000014_gene620 2.566e-24 107.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,25ZXM@186807|Peptococcaceae 186801|Clostridia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII YYD2_k127_4775225_2 118163.Ple7327_3015 9.759e-148 479.0 COG2081@1|root,COG2081@2|Bacteria,1FZZ1@1117|Cyanobacteria,3VIXX@52604|Pleurocapsales 1117|Cyanobacteria S flavoprotein, HI0933 family - - - ko:K07007 - - - - ko00000 - - - HI0933_like YYD2_k127_4775225_5 94624.Bpet1873 1.183e-45 170.0 COG3153@1|root,COG3153@2|Bacteria,1QTXW@1224|Proteobacteria,2WGH8@28216|Betaproteobacteria 28216|Betaproteobacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 YYD2_k127_4775225_6 1278073.MYSTI_07636 6.007e-29 125.0 COG3386@1|root,COG3386@2|Bacteria,1NFEJ@1224|Proteobacteria,43BX0@68525|delta/epsilon subdivisions,2X77S@28221|Deltaproteobacteria,2YVY8@29|Myxococcales 28221|Deltaproteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - YYD2_k127_4775225_10 68223.JNZY01000019_gene7351 1.806e-11 72.0 2D579@1|root,32TID@2|Bacteria,2IMWE@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - YYD2_k127_4775225_9 491205.JARQ01000008_gene3729 1.434e-15 85.0 COG1670@1|root,COG1670@2|Bacteria,4NQZQ@976|Bacteroidetes,1I3J3@117743|Flavobacteriia,3ZQJV@59732|Chryseobacterium 976|Bacteroidetes J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 YYD2_k127_4775225_4 404589.Anae109_2485 7.39e-68 235.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,42MQB@68525|delta/epsilon subdivisions,2WPIA@28221|Deltaproteobacteria,2Z34C@29|Myxococcales 28221|Deltaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase YYD2_k127_4775225_0 1379698.RBG1_1C00001G0426 9.809e-165 527.0 2CD20@1|root,2Z7SQ@2|Bacteria,2NNUF@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4775225_1 706587.Desti_4421 3.069e-151 492.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2MQ8K@213462|Syntrophobacterales 28221|Deltaproteobacteria L PFAM MgsA AAA ATPase C terminal rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N YYD2_k127_4775225_3 1379698.RBG1_1C00001G1345 5.233e-140 459.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria 2|Bacteria KT COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - GAF,GAF_2,HATPase_c_2,SSF,SpoIIE YYD2_k127_4801507_1 1379698.RBG1_1C00001G0118 1.002e-53 196.0 29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4801507_0 344747.PM8797T_23691 4.378e-94 314.0 28MEN@1|root,2ZASA@2|Bacteria,2IZ1H@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD2_k127_4810287_2 269798.CHU_1442 7.818e-62 230.0 COG0308@1|root,COG0308@2|Bacteria,4NEXH@976|Bacteroidetes,47JGQ@768503|Cytophagia 976|Bacteroidetes E PFAM Peptidase M1, membrane alanine aminopeptidase - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M1 YYD2_k127_4810287_0 1408422.JHYF01000002_gene2509 1.318e-76 269.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,36E7J@31979|Clostridiaceae 186801|Clostridia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C YYD2_k127_4810287_1 1379698.RBG1_1C00001G0646 8.957e-65 229.0 COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria 2|Bacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C YYD2_k127_4939932_28 1379698.RBG1_1C00001G0060 2.111e-24 108.0 COG1983@1|root,COG1983@2|Bacteria,2NQ85@2323|unclassified Bacteria 2|Bacteria KT PspC domain pspC - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC YYD2_k127_4939932_32 1122621.ATZA01000015_gene3694 2.916e-08 64.0 2AX7X@1|root,31P6Q@2|Bacteria,4NGGX@976|Bacteroidetes,1ISH8@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_4939932_18 1121468.AUBR01000005_gene92 1.273e-57 209.0 COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,25C2V@186801|Clostridia,42J43@68295|Thermoanaerobacterales 186801|Clostridia ET Ligated ion channel L-glutamate- and glycine-binding site glnH - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 YYD2_k127_4939932_19 1218173.BALCAV_0200475 2.292e-56 204.0 COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,4HFZE@91061|Bacilli,1ZBXZ@1386|Bacillus 91061|Bacilli F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin YYD2_k127_4939932_23 1379698.RBG1_1C00001G1226 4.36e-45 171.0 COG0204@1|root,COG0204@2|Bacteria,2NPW3@2323|unclassified Bacteria 2|Bacteria I Phosphate acyltransferases cmk - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase YYD2_k127_4939932_0 1379698.RBG1_1C00001G1225 1.667e-236 749.0 COG0539@1|root,COG0539@2|Bacteria,2NNTP@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein S1 rpsA GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010 1.17.7.4,2.7.11.1 ko:K02945,ko:K03527,ko:K12132 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko01001,ko03011 - - - S1 YYD2_k127_4939932_11 314285.KT71_11209 1.012e-85 296.0 2DCFR@1|root,2ZDYQ@2|Bacteria,1RB5X@1224|Proteobacteria,1RN4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_4939932_10 264201.pc1763 2.361e-86 301.0 COG0621@1|root,COG0621@2|Bacteria,2JFUS@204428|Chlamydiae 204428|Chlamydiae J Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine mtaB - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 YYD2_k127_4939932_3 1379698.RBG1_1C00001G1649 2.891e-203 642.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,2NNYX@2323|unclassified Bacteria 2|Bacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K02535,ko:K13599,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,ko02020,map00061,map00540,map00780,map01100,map01212,map02020 M00060,M00083,M00498,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005,ko02022 - - - FabA,LpxC YYD2_k127_4939932_8 1379698.RBG1_1C00001G1648 5.163e-99 329.0 COG1043@1|root,COG1043@2|Bacteria,2NP5V@2323|unclassified Bacteria 2|Bacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep YYD2_k127_4939932_12 411154.GFO_0667 9.198e-80 277.0 COG0673@1|root,COG0673@2|Bacteria,4NEC6@976|Bacteroidetes,1HXSP@117743|Flavobacteriia 976|Bacteroidetes S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA YYD2_k127_4939932_14 1382359.JIAL01000001_gene701 1.279e-68 246.0 COG0763@1|root,COG0763@2|Bacteria,3Y34H@57723|Acidobacteria,2JID9@204432|Acidobacteriia 204432|Acidobacteriia M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB YYD2_k127_4939932_15 1121943.KB899996_gene590 8.548e-61 225.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1XHB6@135619|Oceanospirillales 135619|Oceanospirillales M transferase waaA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N YYD2_k127_4939932_24 936589.HMPREF1521_1439 6.324e-39 159.0 COG1663@1|root,COG1663@2|Bacteria,1TWGA@1239|Firmicutes,4H97G@909932|Negativicutes 909932|Negativicutes M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Glycos_transf_N,LpxK YYD2_k127_4939932_4 1379698.RBG1_1C00001G1642 6.699e-162 526.0 COG0029@1|root,COG0029@2|Bacteria,2NNMD@2323|unclassified Bacteria 2|Bacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.3.5.4,1.4.3.16 ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899 FAD_binding_2,Succ_DH_flav_C YYD2_k127_4939932_2 1379698.RBG1_1C00001G1641 1.771e-208 659.0 COG0519@1|root,COG0519@2|Bacteria,2NNRS@2323|unclassified Bacteria 2|Bacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.3.1.128,6.3.5.2 ko:K01951,ko:K03790 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002,ko03009 - - iLJ478.TM1820 GATase,GMP_synt_C,NAD_synthase YYD2_k127_4939932_16 74545.EU96_1521 1.504e-60 216.0 COG3914@1|root,COG3914@2|Bacteria 2|Bacteria O protein N-acetylglucosaminyltransferase activity - - - - - - - - - - - - Methyltransf_21,Sulfotransfer_3 YYD2_k127_4939932_30 518766.Rmar_0873 1.355e-22 104.0 COG0816@1|root,COG0816@2|Bacteria,4NQ8B@976|Bacteroidetes,1FJID@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA ruvX GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX YYD2_k127_4939932_20 330214.NIDE1709 5.584e-55 207.0 COG1559@1|root,COG1559@2|Bacteria,3J0IR@40117|Nitrospirae 40117|Nitrospirae S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG YYD2_k127_4939932_6 1255043.TVNIR_2752 3.302e-109 370.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWGD@135613|Chromatiales 135613|Chromatiales T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_4939932_29 264732.Moth_2010 4.721e-23 101.0 COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,42GW8@68295|Thermoanaerobacterales 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln YYD2_k127_4939932_21 373903.Hore_18930 5.468e-53 198.0 COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,24H2B@186801|Clostridia,3WAKF@53433|Halanaerobiales 186801|Clostridia M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 YYD2_k127_4939932_1 1379698.RBG1_1C00001G0542 1.567e-229 722.0 COG0504@1|root,COG0504@2|Bacteria,2NNVG@2323|unclassified Bacteria 2|Bacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377 CTP_synth_N,GATase YYD2_k127_4939932_27 745014.OMB55_00004060 3.743e-25 120.0 COG1596@1|root,COG1596@2|Bacteria,1PK0T@1224|Proteobacteria,1SXFX@1236|Gammaproteobacteria,1JBNW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB YYD2_k127_4939932_22 909663.KI867150_gene1667 5.741e-46 182.0 COG3206@1|root,COG3206@2|Bacteria,1QUY4@1224|Proteobacteria,42RD1@68525|delta/epsilon subdivisions,2WMV4@28221|Deltaproteobacteria,2MQDI@213462|Syntrophobacterales 28221|Deltaproteobacteria M G-rich domain on putative tyrosine kinase - - - - - - - - - - - - GNVR,Wzz YYD2_k127_4939932_7 857293.CAAU_2200 3.12e-103 340.0 COG1044@1|root,COG1044@2|Bacteria,1UHYP@1239|Firmicutes,25E78@186801|Clostridia,36F2P@31979|Clostridiaceae 186801|Clostridia M Hexapeptide repeat of succinyl-transferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2 YYD2_k127_4939932_5 1379698.RBG1_1C00001G1539 3.378e-136 446.0 COG0399@1|root,COG0399@2|Bacteria,2NNS2@2323|unclassified Bacteria 2|Bacteria E Belongs to the DegT DnrJ EryC1 family degT - - - - - - - - - - - DegT_DnrJ_EryC1 YYD2_k127_4939932_25 945713.IALB_2083 1.285e-31 141.0 COG0728@1|root,COG0728@2|Bacteria 2|Bacteria M peptidoglycan biosynthetic process - - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN YYD2_k127_4939932_17 871968.DESME_14455 3.179e-58 216.0 COG0438@1|root,COG0438@2|Bacteria,1TSNT@1239|Firmicutes,248MH@186801|Clostridia,26327@186807|Peptococcaceae 186801|Clostridia M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 YYD2_k127_4939932_9 234267.Acid_4860 4.594e-91 313.0 COG0399@1|root,COG0399@2|Bacteria,3Y2QT@57723|Acidobacteria 57723|Acidobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 YYD2_k127_4939932_13 886293.Sinac_6637 5.686e-75 263.0 COG1163@1|root,COG1163@2|Bacteria,2IWYP@203682|Planctomycetes 203682|Planctomycetes S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS YYD2_k127_4939932_26 1379698.RBG1_1C00001G0432 4.359e-28 123.0 2BV2G@1|root,32QFC@2|Bacteria,2NR6X@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_4966215_1 425104.Ssed_3642 4.342e-12 71.0 COG3911@1|root,COG3911@2|Bacteria,1RBSG@1224|Proteobacteria,1S31D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AAA domain - - - - - - - - - - - - AAA_28 YYD2_k127_4966215_0 517418.Ctha_1181 4.553e-14 85.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 YYD2_k127_5009760_10 502025.Hoch_6850 3.072e-30 125.0 COG0625@1|root,COG0625@2|Bacteria,1PG5Y@1224|Proteobacteria,435HT@68525|delta/epsilon subdivisions,2WZVH@28221|Deltaproteobacteria,2Z2U4@29|Myxococcales 28221|Deltaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - - YYD2_k127_5009760_14 1131269.AQVV01000010_gene2434 1.899e-14 75.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_5009760_7 880073.Calab_2347 2.213e-49 184.0 COG2386@1|root,COG2386@2|Bacteria,2NPHG@2323|unclassified Bacteria 2|Bacteria O CcmB protein ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193,ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iECO111_1330.ECO111_2936,iYL1228.KPN_02080 CcmB YYD2_k127_5009760_12 945713.IALB_3081 1.038e-16 81.0 COG1131@1|root,COG1131@2|Bacteria 2|Bacteria V ATPase activity ccmA - 3.6.3.41 ko:K01990,ko:K02193 ko02010,map02010 M00254,M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.107 - - ABC_tran YYD2_k127_5009760_11 1089550.ATTH01000001_gene2566 4.699e-19 91.0 COG1131@1|root,COG1131@2|Bacteria,4NN9G@976|Bacteroidetes,1FJCH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V ABC transporter - - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran YYD2_k127_5009760_6 1379698.RBG1_1C00001G0425 5.314e-73 254.0 COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria 2|Bacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 YYD2_k127_5009760_5 1379698.RBG1_1C00001G0410 3.532e-96 326.0 COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria 2|Bacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 YYD2_k127_5009760_4 324925.Ppha_0080 3.874e-105 353.0 COG0743@1|root,COG0743@2|Bacteria,1FD70@1090|Chlorobi 1090|Chlorobi I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom YYD2_k127_5009760_8 497964.CfE428DRAFT_2964 6.975e-45 170.0 COG0652@1|root,COG0652@2|Bacteria,46VEN@74201|Verrucomicrobia 74201|Verrucomicrobia O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase YYD2_k127_5009760_17 649638.Trad_2684 6.978e-05 55.0 COG2340@1|root,COG2340@2|Bacteria,1WMWS@1297|Deinococcus-Thermus 2|Bacteria D Allergen V5 Tpx-1 family protein - - - - - - - - - - - - CAP,DUF4214 YYD2_k127_5009760_3 880073.Calab_0626 3.749e-105 349.0 COG1250@1|root,COG1250@2|Bacteria,2NQAW@2323|unclassified Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain hbd2 - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N YYD2_k127_5009760_1 1191523.MROS_1926 1.123e-168 539.0 COG0282@1|root,COG0282@2|Bacteria 2|Bacteria F acetate kinase activity ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase YYD2_k127_5009760_9 1280949.HAD_06100 4.218e-40 172.0 29AWA@1|root,2ZXVE@2|Bacteria,1PAB6@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - YYD2_k127_5009760_15 926551.KB900739_gene62 1.096e-12 77.0 2EGT8@1|root,33AJC@2|Bacteria,4NY9U@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_5009760_0 1379698.RBG1_1C00001G1802 1.587e-183 582.0 COG0538@1|root,COG0538@2|Bacteria,2NS4M@2323|unclassified Bacteria 2|Bacteria C Isocitrate/isopropylmalate dehydrogenase icd GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh YYD2_k127_5009760_2 1379698.RBG1_1C00001G1803 3.135e-129 419.0 COG0039@1|root,COG0039@2|Bacteria,2NNY8@2323|unclassified Bacteria 2|Bacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0004470,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1360 Ldh_1_C,Ldh_1_N YYD2_k127_5009760_13 158190.SpiGrapes_3132 9.615e-16 83.0 COG3875@1|root,COG3875@2|Bacteria,2J6AY@203691|Spirochaetes 203691|Spirochaetes S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 YYD2_k127_5059192_0 204669.Acid345_3116 2.596e-120 419.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y3HX@57723|Acidobacteria,2JHJ9@204432|Acidobacteriia 204432|Acidobacteriia KLT Protein kinase domain - - 2.7.11.1 ko:K08884 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,TPR_8 YYD2_k127_5065282_1 1313301.AUGC01000008_gene468 2.204e-48 176.0 COG3590@1|root,COG3590@2|Bacteria,4NEYB@976|Bacteroidetes 976|Bacteroidetes O peptidase family M13 pepO - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N YYD2_k127_5065282_0 1123073.KB899241_gene2325 1.247e-95 318.0 COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,1S0J9@1236|Gammaproteobacteria,1X3D8@135614|Xanthomonadales 135614|Xanthomonadales U Involved in the import of queuosine (Q) precursors, required for Q precursor salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 YYD2_k127_5065282_2 290397.Adeh_2802 4.554e-20 92.0 2EK70@1|root,33DXD@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_50658_13 880073.Calab_1842 8.415e-41 156.0 COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria 2|Bacteria M Transglycosylase mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase YYD2_k127_50658_16 1449044.JMLE01000012_gene3038 1.301e-16 83.0 COG4335@1|root,COG4335@2|Bacteria,2HDE9@201174|Actinobacteria 201174|Actinobacteria L DNA alkylation repair - - - - - - - - - - - - DNA_alkylation YYD2_k127_50658_5 518766.Rmar_1440 1.134e-92 316.0 COG0845@1|root,COG0845@2|Bacteria,4NFT4@976|Bacteroidetes 976|Bacteroidetes M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP YYD2_k127_50658_3 518766.Rmar_1441 2.347e-98 336.0 COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes 976|Bacteroidetes V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_50658_2 518766.Rmar_1442 3.194e-106 360.0 COG0577@1|root,COG0577@2|Bacteria,4NECN@976|Bacteroidetes,1FIY8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_50658_8 55601.VANGNB10_cII0274c 9.69e-77 263.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XSYR@135623|Vibrionales 135623|Vibrionales V Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_50658_0 247490.KSU1_C0602 3.03e-140 456.0 COG2133@1|root,COG2133@2|Bacteria,2IXAF@203682|Planctomycetes 203682|Planctomycetes G glucose sorbosone - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - DUF1080,GSDH,SGL YYD2_k127_50658_7 671143.DAMO_0825 1.043e-79 280.0 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria 2|Bacteria C Cytochrome b subunit of formate dehydrogenase-like protein mccA GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016002,GO:0016043,GO:0016491,GO:0016667,GO:0017144,GO:0019748,GO:0020037,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044272,GO:0044550,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051259,GO:0051260,GO:0055114,GO:0065003,GO:0070206,GO:0070207,GO:0070813,GO:0070814,GO:0071840,GO:0097159,GO:1901363,GO:1903136 - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1 YYD2_k127_50658_9 204669.Acid345_2713 3.528e-63 229.0 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria 57723|Acidobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB YYD2_k127_50658_11 880072.Desac_0068 2.422e-52 196.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WR70@28221|Deltaproteobacteria 28221|Deltaproteobacteria C formate dehydrogenase - - - - - - - - - - - - - YYD2_k127_50658_6 1125863.JAFN01000001_gene1695 7.827e-81 288.0 COG3005@1|root,COG3005@2|Bacteria,1RJ3G@1224|Proteobacteria,42ST3@68525|delta/epsilon subdivisions 1224|Proteobacteria C NapC/NirT cytochrome c family, N-terminal region - - - - - - - - - - - - Cytochrom_CIII,Cytochrom_NNT,Cytochrome_C7 YYD2_k127_50658_15 243274.THEMA_00010 2.174e-26 116.0 COG0220@1|root,COG0220@2|Bacteria,2GCR3@200918|Thermotogae 200918|Thermotogae J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 YYD2_k127_50658_17 1210884.HG799465_gene11731 3.408e-14 76.0 COG1393@1|root,COG1393@2|Bacteria,2J19I@203682|Planctomycetes 203682|Planctomycetes P Belongs to the ArsC family - - - - - - - - - - - - - YYD2_k127_50658_14 927658.AJUM01000034_gene466 5.845e-40 156.0 COG1376@1|root,COG1376@2|Bacteria,4P35B@976|Bacteroidetes 976|Bacteroidetes S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD YYD2_k127_50658_12 518766.Rmar_0610 1.728e-43 173.0 COG3034@1|root,COG3034@2|Bacteria,4NU5W@976|Bacteroidetes 976|Bacteroidetes M L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD YYD2_k127_50658_18 518766.Rmar_0609 6.104e-12 74.0 2FFT5@1|root,347QA@2|Bacteria,4P5W2@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - DUF4398 YYD2_k127_50658_1 1191523.MROS_1186 2.267e-122 409.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT,Cytochrom_c3_2 YYD2_k127_50658_4 716544.wcw_0742 4.31e-94 317.0 COG1090@1|root,COG1090@2|Bacteria,2JFV6@204428|Chlamydiae 204428|Chlamydiae S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase YYD2_k127_50658_10 452637.Oter_0920 8.172e-58 209.0 COG0842@1|root,COG0842@2|Bacteria,46SWI@74201|Verrucomicrobia,3K9GH@414999|Opitutae 74201|Verrucomicrobia U ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 YYD2_k127_5071134_27 316274.Haur_3591 4.991e-41 166.0 COG4948@1|root,COG4948@2|Bacteria,2G882@200795|Chloroflexi,3757P@32061|Chloroflexia 2|Bacteria M mandelate racemase muconate lactonizing ycjG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - iEC042_1314.EC042_1441,iECUMN_1333.ECUMN_1620 MR_MLE_C,MR_MLE_N YYD2_k127_5071134_37 986075.CathTA2_0647 1.689e-24 113.0 COG0791@1|root,COG0791@2|Bacteria,1TSZ0@1239|Firmicutes,4HBUM@91061|Bacilli 91061|Bacilli M COG0791 Cell wall-associated hydrolases (invasion-associated proteins) ykfC - 3.4.14.13 ko:K20742 - - - - ko00000,ko01000,ko01002 - - - NLPC_P60 YYD2_k127_5071134_34 1536772.R70723_10700 4.745e-30 127.0 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,26WY5@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08510 CoaE YYD2_k127_5071134_0 1379698.RBG1_1C00001G0871 9.884e-308 968.0 COG0749@1|root,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria 2|Bacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 YYD2_k127_5071134_30 1210884.HG799463_gene9385 1.714e-35 143.0 COG1057@1|root,COG1057@2|Bacteria,2IZMU@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like YYD2_k127_5071134_33 1379698.RBG1_1C00001G0869 1.585e-32 138.0 COG4105@1|root,COG4105@2|Bacteria,2NPZ3@2323|unclassified Bacteria 2|Bacteria S Outer membrane lipoprotein yfiO - - ko:K05807,ko:K08309 - - - - ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 - YfiO YYD2_k127_5071134_23 1379698.RBG1_1C00001G0868 1.234e-58 210.0 COG0741@1|root,COG0741@2|Bacteria,2NPKN@2323|unclassified Bacteria 2|Bacteria M Transglycosylase SLT domain slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,TPR_16,TPR_6 YYD2_k127_5071134_10 857293.CAAU_1723 1.57e-102 348.0 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,36E1K@31979|Clostridiaceae 186801|Clostridia J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 YYD2_k127_5071134_40 1379698.RBG1_1C00001G0867 0.0001699 51.0 COG2834@1|root,COG2834@2|Bacteria,2NQ6V@2323|unclassified Bacteria 2|Bacteria M Outer membrane lipoprotein carrier protein LolA - - - ko:K03634 - - - - ko00000 - - - LolA YYD2_k127_5071134_1 1379698.RBG1_1C00001G0866 2.429e-204 660.0 COG1674@1|root,COG1674@2|Bacteria,2NNVB@2323|unclassified Bacteria 2|Bacteria D Ftsk_gamma ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma YYD2_k127_5071134_36 330214.NIDE0404 1.002e-25 108.0 COG0776@1|root,COG0776@2|Bacteria,3J0V6@40117|Nitrospirae 40117|Nitrospirae L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions - - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding YYD2_k127_5071134_3 1379698.RBG1_1C00001G0864 4.505e-151 520.0 COG1452@1|root,COG1452@2|Bacteria,2NPN2@2323|unclassified Bacteria 2|Bacteria M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - ko:K04744,ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - LptC,OstA,OstA_C YYD2_k127_5071134_20 1444309.JAQG01000021_gene1409 1.531e-67 245.0 COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,4HADV@91061|Bacilli,26SSK@186822|Paenibacillaceae 91061|Bacilli J Related to alanyl-tRNA synthetase HxxxH domain alaS_2 - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD YYD2_k127_5071134_32 1033743.CAES01000101_gene3607 5.248e-35 153.0 COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,4HDA6@91061|Bacilli,275PA@186822|Paenibacillaceae 91061|Bacilli E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 YYD2_k127_5071134_15 138119.DSY1897 1.322e-79 273.0 COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,263G2@186807|Peptococcaceae 186801|Clostridia Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - - - - - - - - - - DUF2437,FAA_hydrolase YYD2_k127_5071134_17 309801.trd_0179 2.771e-74 260.0 COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi,27XTE@189775|Thermomicrobia 189775|Thermomicrobia BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl YYD2_k127_5071134_14 880073.Calab_0837 5.95e-89 309.0 COG0534@1|root,COG0534@2|Bacteria,2NPBA@2323|unclassified Bacteria 2|Bacteria V MATE efflux family protein mepA_10 - - - - - - - - - - - MatE YYD2_k127_5071134_25 279010.BL01544 2.796e-51 185.0 COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,4HJ2V@91061|Bacilli,1ZG8H@1386|Bacillus 91061|Bacilli E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II YYD2_k127_5071134_19 1502770.JQMG01000001_gene601 1.2e-70 252.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,2KMCZ@206350|Nitrosomonadales 206350|Nitrosomonadales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase YYD2_k127_5071134_35 436114.SYO3AOP1_0528 6.793e-26 114.0 COG0703@1|root,COG0703@2|Bacteria,2G46N@200783|Aquificae 200783|Aquificae F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI YYD2_k127_5071134_31 444158.MmarC6_1719 1.757e-35 146.0 COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,23QN8@183939|Methanococci 183939|Methanococci E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0003674,GO:0003824,GO:0004764,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0055114,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N YYD2_k127_5071134_13 180332.JTGN01000007_gene3507 9.032e-96 329.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase YYD2_k127_5071134_4 1382359.JIAL01000001_gene383 1.98e-140 453.0 COG2876@1|root,COG2876@2|Bacteria,3Y32G@57723|Acidobacteria,2JIXH@204432|Acidobacteriia 204432|Acidobacteriia E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 YYD2_k127_5071134_8 247490.KSU1_B0226 1.478e-108 364.0 COG0018@1|root,COG0018@2|Bacteria,2IX9Y@203682|Planctomycetes 203682|Planctomycetes J arginyl-trna synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d YYD2_k127_5071134_29 1511.CLOST_1149 5.171e-40 156.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,25QY6@186804|Peptostreptococcaceae 186801|Clostridia J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d YYD2_k127_5071134_24 477974.Daud_1185 8.317e-58 211.0 COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,261Y5@186807|Peptococcaceae 186801|Clostridia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA YYD2_k127_5071134_2 1382303.JPOM01000001_gene1992 8.907e-171 544.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,2KFB5@204458|Caulobacterales 204458|Caulobacterales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP YYD2_k127_5071134_28 1182590.BN5_02125 4.978e-40 156.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1YD0W@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI YYD2_k127_5071134_21 1449126.JQKL01000014_gene2975 5.911e-64 228.0 COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia,268Z9@186813|unclassified Clostridiales 186801|Clostridia E Indole-3-glycerol phosphate synthase trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS YYD2_k127_5071134_22 351160.RCIX86 6.58e-62 229.0 COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia 224756|Methanomicrobia G MFS/sugar transport protein - - - - - - - - - - - - MFS_1 YYD2_k127_5071134_12 644966.Tmar_1454 3.417e-96 327.0 COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,3WCZN@538999|Clostridiales incertae sedis 186801|Clostridia E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 YYD2_k127_5071134_16 321332.CYB_2417 9.638e-75 255.0 COG0512@1|root,COG0512@2|Bacteria,1G0QK@1117|Cyanobacteria,1GZ8F@1129|Synechococcus 1117|Cyanobacteria EH Anthranilate synthase trpG - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase YYD2_k127_5071134_6 330214.NIDE2040 2.517e-134 444.0 COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae 40117|Nitrospirae EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind YYD2_k127_5071134_26 871968.DESME_12035 2.171e-49 186.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,260JZ@186807|Peptococcaceae 186801|Clostridia E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase YYD2_k127_5071134_7 696281.Desru_0552 1.633e-114 381.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,260DD@186807|Peptococcaceae 186801|Clostridia EK PFAM Aminotransferase class I and II - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 YYD2_k127_5071134_39 306263.Cla_0288 8.774e-06 49.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2YMPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S hmm pf04305 - - - - - - - - - - - - DUF455 YYD2_k127_5071134_18 1379698.RBG1_1C00001G1046 8.904e-72 254.0 COG1940@1|root,COG1940@2|Bacteria,2NPRP@2323|unclassified Bacteria 2|Bacteria GK ROK family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK YYD2_k127_5071134_38 768706.Desor_3321 5.229e-10 69.0 COG2227@1|root,COG2227@2|Bacteria,1UJIQ@1239|Firmicutes,25F3P@186801|Clostridia,2631M@186807|Peptococcaceae 186801|Clostridia H Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_25 YYD2_k127_5071134_11 945713.IALB_0857 4.519e-98 331.0 COG0348@1|root,COG0348@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - Fer4_10,Fer4_5 YYD2_k127_5071134_9 1333998.M2A_1415 2.591e-106 361.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,4BPJZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His YYD2_k127_5071134_5 945713.IALB_1148 1.166e-139 448.0 COG2079@1|root,COG2079@2|Bacteria 2|Bacteria S 2-methylcitrate dehydratase activity prpD GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD YYD2_k127_5083453_10 1191523.MROS_2159 1.4e-76 267.0 COG1706@1|root,COG1706@2|Bacteria 2|Bacteria N bacterial-type flagellum-dependent cell motility flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI YYD2_k127_5083453_21 1303518.CCALI_02080 3.52e-24 110.0 COG2063@1|root,COG2063@2|Bacteria 2|Bacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K01991,ko:K02393 ko02026,ko02040,map02026,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.B.18 - - FlgH YYD2_k127_5083453_27 1192868.CAIU01000025_gene3600 0.0001485 52.0 COG1261@1|root,COG1261@2|Bacteria,1MZIR@1224|Proteobacteria,2TTEA@28211|Alphaproteobacteria,43KKW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria N Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly - - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA YYD2_k127_5083453_5 760142.Hipma_0728 7.127e-101 334.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2WJDN@28221|Deltaproteobacteria,2M6GB@213113|Desulfurellales 28221|Deltaproteobacteria N Flagellar basal body rod FlgEFG protein C-terminal flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C YYD2_k127_5083453_15 1009370.ALO_10009 2.229e-40 158.0 COG4786@1|root,COG4786@2|Bacteria,1TRFQ@1239|Firmicutes,4H3AU@909932|Negativicutes 909932|Negativicutes N flagellar basal-body rod protein - - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C YYD2_k127_5083453_20 880073.Calab_0041 1.811e-24 117.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase YYD2_k127_5083453_29 1282887.AUJG01000007_gene2399 0.0004662 49.0 COG2882@1|root,COG2882@2|Bacteria,1VK96@1239|Firmicutes,24RWK@186801|Clostridia 186801|Clostridia NOU flagellar export protein FliJ fliJ - - ko:K02413 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliJ YYD2_k127_5083453_0 1123288.SOV_1c11670 2.737e-169 542.0 COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,4H2V3@909932|Negativicutes 909932|Negativicutes N Flagellar protein export ATPase FliI fliI - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N YYD2_k127_5083453_22 1125863.JAFN01000001_gene699 1.213e-18 96.0 COG1317@1|root,COG1317@2|Bacteria,1NJAJ@1224|Proteobacteria,42P5I@68525|delta/epsilon subdivisions,2WSGD@28221|Deltaproteobacteria 28221|Deltaproteobacteria N PFAM Flagellar assembly protein FliH fliH - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH YYD2_k127_5083453_4 1449126.JQKL01000001_gene1325 5.546e-102 342.0 COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia,267T2@186813|unclassified Clostridiales 186801|Clostridia N FliG C-terminal domain fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N YYD2_k127_5083453_6 1191523.MROS_2129 4.353e-97 336.0 COG1766@1|root,COG1766@2|Bacteria 2|Bacteria N bacterial-type flagellum-dependent cell motility fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C YYD2_k127_5083453_24 398512.JQKC01000007_gene1149 5.997e-13 73.0 COG1677@1|root,COG1677@2|Bacteria,1VEEY@1239|Firmicutes,24R4F@186801|Clostridia,3WKN2@541000|Ruminococcaceae 186801|Clostridia N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE YYD2_k127_5083453_18 373903.Hore_16910 1.181e-33 135.0 COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,24JJW@186801|Clostridia,3WBUF@53433|Halanaerobiales 186801|Clostridia N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C YYD2_k127_5083453_28 1127673.GLIP_2549 0.0002042 49.0 COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,1S9DS@1236|Gammaproteobacteria,467QG@72275|Alteromonadaceae 1236|Gammaproteobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod YYD2_k127_5083453_12 643648.Slip_1876 1.515e-58 213.0 COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia,42K2U@68298|Syntrophomonadaceae 186801|Clostridia N OmpA family motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA YYD2_k127_5083453_9 909663.KI867150_gene1996 9.454e-80 274.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42PR1@68525|delta/epsilon subdivisions,2WIQ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria N PFAM MotA TolQ ExbB proton channel motA - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB YYD2_k127_5083453_2 1379698.RBG1_1C00001G1274 4.397e-151 490.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family atoC - - ko:K07712,ko:K07713,ko:K07714,ko:K10943 ko02020,ko05111,map02020,map05111 M00497,M00499,M00500,M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_5083453_11 1379698.RBG1_1C00001G1275 7.36e-72 259.0 COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria 2|Bacteria T Signal transduction histidine kinase, nitrogen specific, NtrB atoS - 2.7.13.3 ko:K07708,ko:K07710,ko:K10942 ko02020,ko05111,map02020,map05111 M00497,M00500,M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_8,PAS_9 YYD2_k127_5083453_3 518766.Rmar_0772 3.351e-113 376.0 COG2201@1|root,COG2201@2|Bacteria,4NHMU@976|Bacteroidetes,1FJZC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg YYD2_k127_5083453_1 118005.AWNK01000006_gene1181 3.805e-168 550.0 COG0643@1|root,COG0643@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg YYD2_k127_5083453_25 379066.GAU_0359 8.008e-09 64.0 2F57Y@1|root,33XUE@2|Bacteria,1ZTSK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - YYD2_k127_5083453_13 118005.AWNK01000006_gene1183 2.803e-44 166.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg YYD2_k127_5083453_17 1191523.MROS_2120 5.027e-34 139.0 COG0745@1|root,COG0745@2|Bacteria 1191523.MROS_2120|- T phosphorelay signal transduction system - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - - YYD2_k127_5083453_8 882.DVU_2076 4.688e-85 292.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QJT@68525|delta/epsilon subdivisions,2WJ1S@28221|Deltaproteobacteria,2M8MF@213115|Desulfovibrionales 28221|Deltaproteobacteria NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N YYD2_k127_5083453_19 639282.DEFDS_1712 7.7e-29 120.0 COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,2GETM@200930|Deferribacteres 200930|Deferribacteres T HD domain - - - - - - - - - - - - HD_5,Response_reg YYD2_k127_5083453_16 243231.GSU2216 6.872e-38 162.0 COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WPWV@28221|Deltaproteobacteria,43UH8@69541|Desulfuromonadales 28221|Deltaproteobacteria C HEAT repeat - - - - - - - - - - - - HEAT,HEAT_2,HEAT_PBS YYD2_k127_5083453_23 313612.L8106_20448 2.736e-13 74.0 COG1366@1|root,COG1366@2|Bacteria,1GA96@1117|Cyanobacteria,1HD2N@1150|Oscillatoriales 1117|Cyanobacteria T Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) - - - - - - - - - - - - STAS,STAS_2 YYD2_k127_5083453_26 1266998.ATUJ01000009_gene529 7.601e-05 50.0 COG2172@1|root,COG2172@2|Bacteria,1NIPM@1224|Proteobacteria,2UMM5@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase-like ATPase domain - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 YYD2_k127_5083453_14 1499967.BAYZ01000159_gene502 7.031e-42 172.0 COG2203@1|root,COG2208@1|root,COG3437@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3437@2|Bacteria,2NQW9@2323|unclassified Bacteria 2|Bacteria KT Sigma factor PP2C-like phosphatases rsbU - 3.1.3.3,4.6.1.1 ko:K01079,ko:K01768,ko:K07315 ko00230,ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02025,ko04113,ko04213,map00230,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02025,map04113,map04213 M00020,M00695 R00089,R00434,R00582 RC00017,RC00295 ko00000,ko00001,ko00002,ko01000,ko01009,ko03021 - - - FHA,GAF,GAF_2,GAF_3,HATPase_c_2,Response_reg,SSF,SpoIIE YYD2_k127_5083453_7 1031288.AXAA01000001_gene2202 6.54e-92 311.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,36DFQ@31979|Clostridiaceae 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 YYD2_k127_5119286_2 1379698.RBG1_1C00001G0100 2.421e-59 214.0 COG0325@1|root,COG0325@2|Bacteria,2NPEW@2323|unclassified Bacteria 2|Bacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis ylmE GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - ko:K06997 - - - - ko00000 - - - Ala_racemase_N YYD2_k127_5119286_4 292459.STH1230 8.212e-11 74.0 COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,24MM3@186801|Clostridia 186801|Clostridia D PFAM DivIVA family protein divIVA - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA YYD2_k127_5119286_3 661478.OP10G_0268 6.706e-23 103.0 COG3795@1|root,COG3795@2|Bacteria 2|Bacteria F YCII-related domain - - - - - - - - - - - - DoxX_2,YCII YYD2_k127_5119286_0 1396418.BATQ01000056_gene225 5.446e-114 383.0 COG4941@1|root,COG4941@2|Bacteria,46SEY@74201|Verrucomicrobia,2IV8H@203494|Verrucomicrobiae 203494|Verrucomicrobiae K Sigma-70 region 2 - - - - - - - - - - - - Sigma70_r2 YYD2_k127_5119286_1 1121472.AQWN01000002_gene2173 1.221e-83 286.0 COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,2619Q@186807|Peptococcaceae 186801|Clostridia C PFAM Flavodoxin fprA2 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0016661,GO:0016662,GO:0016966,GO:0022900,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050664,GO:0055114,GO:0072593,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B,Pyr_redox_2 YYD2_k127_5175797_0 1379698.RBG1_1C00001G0607 3.907e-128 434.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 YYD2_k127_5175797_6 1286632.P278_18520 7.313e-27 112.0 COG2388@1|root,COG2388@2|Bacteria,4NUS6@976|Bacteroidetes,1I57A@117743|Flavobacteriia 976|Bacteroidetes S (GNAT) family - - - ko:K06975 - - - - ko00000 - - - Acetyltransf_CG YYD2_k127_5175797_3 1121904.ARBP01000012_gene1285 1.187e-52 188.0 COG3369@1|root,COG3592@1|root,COG3369@2|Bacteria,COG3592@2|Bacteria,4NVG3@976|Bacteroidetes,47QRI@768503|Cytophagia 976|Bacteroidetes S Divergent 4Fe-4S mono-cluster - - - - - - - - - - - - Fer4_19,zf-CDGSH YYD2_k127_5175797_2 379066.GAU_0974 6.921e-58 206.0 29KMP@1|root,307IZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4287 YYD2_k127_5175797_4 929556.Solca_2518 1.663e-50 184.0 2CMS6@1|root,32SFE@2|Bacteria,4NWI0@976|Bacteroidetes,1IYER@117747|Sphingobacteriia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 YYD2_k127_5175797_1 153721.MYP_33 1.179e-73 258.0 COG0077@1|root,COG0077@2|Bacteria,4NEEK@976|Bacteroidetes,47NM0@768503|Cytophagia 976|Bacteroidetes E PFAM Prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT YYD2_k127_5175797_5 945713.IALB_3117 3.06e-40 153.0 2DTJ6@1|root,33KM6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5175797_7 1121287.AUMU01000008_gene1918 2.868e-05 47.0 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes,1I2T3@117743|Flavobacteriia,3ZS40@59732|Chryseobacterium 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 YYD2_k127_5181733_7 215803.DB30_0085 1.56e-36 151.0 COG3746@1|root,COG3746@2|Bacteria,1PBWD@1224|Proteobacteria,433TT@68525|delta/epsilon subdivisions,2X3F8@28221|Deltaproteobacteria,2YVU2@29|Myxococcales 28221|Deltaproteobacteria P phosphate-selective porin O and P - - - - - - - - - - - - - YYD2_k127_5181733_0 1232410.KI421421_gene3404 3.785e-182 588.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,43SD2@69541|Desulfuromonadales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,sCache_like YYD2_k127_5181733_1 880072.Desac_2636 1.301e-100 332.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales 28221|Deltaproteobacteria K PFAM response regulator receiver - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C YYD2_k127_5181733_5 313612.L8106_12700 4.013e-79 289.0 COG2931@1|root,COG2931@2|Bacteria,1G0DX@1117|Cyanobacteria,1H9Z9@1150|Oscillatoriales 1117|Cyanobacteria QU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Calx-beta,DUF4347,HemolysinCabind,SdrD_B,VCBS YYD2_k127_5181733_9 795666.MW7_3482 3e-05 56.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VKXA@28216|Betaproteobacteria,1K2ZY@119060|Burkholderiaceae 28216|Betaproteobacteria S 40-residue YVTN family beta-propeller repeat protein - - - - - - - - - - - - Cytochrom_D1,Lactonase YYD2_k127_5181733_3 747365.Thena_0240 1.091e-83 291.0 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,42I94@68295|Thermoanaerobacterales 186801|Clostridia E COGs COG0683 ABC-type branched-chain amino acid transport systems periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 YYD2_k127_5181733_2 671143.DAMO_1397 1.461e-90 306.0 COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid transport system / permease component livH GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iJN746.PP_4866,iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288 BPD_transp_2 YYD2_k127_5181733_6 56780.SYN_00787 6.91e-72 256.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,439ZK@68525|delta/epsilon subdivisions,2X25M@28221|Deltaproteobacteria,2MRP1@213462|Syntrophobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 YYD2_k127_5181733_4 1504672.669783731 1.624e-82 287.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,4A9JJ@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C YYD2_k127_5181733_10 1514668.JOOA01000002_gene2294 0.0005206 47.0 COG5279@1|root,COG5279@2|Bacteria,1VCSW@1239|Firmicutes,24MZR@186801|Clostridia,3WRN8@541000|Ruminococcaceae 186801|Clostridia D Transglutaminase-like superfamily - - - - - - - - - - - - Flg_new,Transglut_core,fn3 YYD2_k127_5184919_0 387631.Asulf_00513 2.208e-36 143.0 COG0346@1|root,arCOG02706@2157|Archaea,2XY0R@28890|Euryarchaeota,2469B@183980|Archaeoglobi 183980|Archaeoglobi E Glyoxalase-like domain - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 YYD2_k127_5184919_1 697282.Mettu_3684 2.137e-28 118.0 2E3V1@1|root,32YSA@2|Bacteria,1N7HB@1224|Proteobacteria,1SF7K@1236|Gammaproteobacteria,1XGMP@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - YYD2_k127_5184919_2 1499968.TCA2_3865 7.195e-16 81.0 COG3682@1|root,COG3682@2|Bacteria,1VGZ0@1239|Firmicutes,4IRZT@91061|Bacilli,276ZA@186822|Paenibacillaceae 91061|Bacilli K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R YYD2_k127_5242940_2 1379698.RBG1_1C00001G1787 3.389e-19 93.0 COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria,2NPRE@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - DUF1863,PQQ_2 YYD2_k127_5242940_1 1379698.RBG1_1C00001G1786 1.92e-26 121.0 2CUTJ@1|root,32SW3@2|Bacteria,2NRD1@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5242940_4 880073.Calab_1398 7.609e-12 75.0 2EAWV@1|root,334Y2@2|Bacteria,2NRSF@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5242940_3 1303518.CCALI_00291 5.988e-12 77.0 COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - NHL YYD2_k127_5242940_0 1379698.RBG1_1C00001G1783 3.755e-43 178.0 COG5448@1|root,COG5448@2|Bacteria,2NPPC@2323|unclassified Bacteria 2|Bacteria S Glycoside hydrolase family 24 - - - - - - - - - - - - DUF2460 YYD2_k127_5265471_1 1379698.RBG1_1C00001G1123 4.479e-205 651.0 COG1418@1|root,COG1418@2|Bacteria,2NNU5@2323|unclassified Bacteria 2|Bacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 YYD2_k127_5265471_19 555088.DealDRAFT_2681 5.418e-09 61.0 COG3027@1|root,COG3027@2|Bacteria,1UFX5@1239|Firmicutes,25MWM@186801|Clostridia,42K8N@68298|Syntrophomonadaceae 186801|Clostridia D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA YYD2_k127_5265471_2 1379698.RBG1_1C00001G1120 6.008e-194 631.0 COG0072@1|root,COG0072@2|Bacteria,2NNXI@2323|unclassified Bacteria 2|Bacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind YYD2_k127_5265471_3 1089548.KI783301_gene455 1.356e-108 361.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,4HAVN@91061|Bacilli,3WEMW@539002|Bacillales incertae sedis 91061|Bacilli J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d YYD2_k127_5265471_12 1379698.RBG1_1C00001G1118 2.355e-35 137.0 COG0292@1|root,COG0292@2|Bacteria,2NPQQ@2323|unclassified Bacteria 2|Bacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 YYD2_k127_5265471_16 28258.KP05_13715 2.014e-15 77.0 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1XM10@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p YYD2_k127_5265471_8 1379698.RBG1_1C00001G1116 2.67e-58 209.0 COG0290@1|root,COG0290@2|Bacteria,2NPDH@2323|unclassified Bacteria 2|Bacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N YYD2_k127_5265471_0 1269813.ATUL01000025_gene2750 4.775e-236 746.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1WVYK@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD YYD2_k127_5265471_10 933262.AXAM01000030_gene823 5.734e-43 168.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WP0E@28221|Deltaproteobacteria,2MJVK@213118|Desulfobacterales 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD YYD2_k127_5265471_17 56780.SYN_02806 1.968e-14 78.0 COG1516@1|root,COG1516@2|Bacteria,1PSYY@1224|Proteobacteria,42V8K@68525|delta/epsilon subdivisions,2WRH1@28221|Deltaproteobacteria 28221|Deltaproteobacteria N PFAM flagellar protein FliS fliS - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS YYD2_k127_5265471_5 1125863.JAFN01000001_gene217 2.14e-89 323.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,42MHW@68525|delta/epsilon subdivisions,2WNU5@28221|Deltaproteobacteria 28221|Deltaproteobacteria N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N YYD2_k127_5265471_7 1210884.HG799473_gene15053 1.257e-60 235.0 COG1344@1|root,COG1344@2|Bacteria,2IX6G@203682|Planctomycetes 203682|Planctomycetes N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N YYD2_k127_5265471_6 237368.SCABRO_02315 2.977e-61 240.0 COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,2J07E@203682|Planctomycetes 203682|Planctomycetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_trans_1_2,Glycos_transf_2,Methyltransf_23,TPR_16,TPR_19,TPR_7,TPR_8 YYD2_k127_5265471_14 641107.CDLVIII_5022 5.97e-25 110.0 COG1699@1|root,COG1699@2|Bacteria,1VA6Y@1239|Firmicutes,24QXE@186801|Clostridia,36JMK@31979|Clostridiaceae 186801|Clostridia S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW YYD2_k127_5265471_11 1131269.AQVV01000022_gene2229 1.924e-42 177.0 COG1344@1|root,COG1344@2|Bacteria 2|Bacteria N bacterial-type flagellum-dependent cell motility flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N YYD2_k127_5265471_15 1379698.RBG1_1C00001G1112 4.237e-19 91.0 COG1551@1|root,COG1551@2|Bacteria,2NQ31@2323|unclassified Bacteria 2|Bacteria J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563,ko:K13626 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko02035,ko03019 - - - CsrA YYD2_k127_5265471_4 635013.TherJR_2798 2.163e-91 319.0 COG1256@1|root,COG4786@1|root,COG1256@2|Bacteria,COG4786@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia,260KA@186807|Peptococcaceae 186801|Clostridia N TIGRFAM Flagellar hook-associated protein, FlgK flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C YYD2_k127_5265471_20 509191.AEDB02000049_gene4382 5.2e-07 57.0 COG3418@1|root,COG3418@2|Bacteria,1VF67@1239|Firmicutes,24SF3@186801|Clostridia,3WPHI@541000|Ruminococcaceae 186801|Clostridia NOU FlgN protein - - - - - - - - - - - - FlgN YYD2_k127_5265471_13 944480.ATUV01000001_gene764 1.659e-34 145.0 COG0741@1|root,COG3951@1|root,COG0741@2|Bacteria,COG3951@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WQZU@28221|Deltaproteobacteria,2M6MZ@213113|Desulfurellales 28221|Deltaproteobacteria MNO Rod binding protein - - - - - - - - - - - - Rod-binding,SLT YYD2_k127_5265471_9 1304874.JAFY01000007_gene1974 2.327e-45 170.0 COG1706@1|root,COG1706@2|Bacteria,3TA0P@508458|Synergistetes 508458|Synergistetes N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI YYD2_k127_5289902_4 1379698.RBG1_1C00001G1245 7.562e-62 237.0 COG1629@1|root,COG4771@2|Bacteria,2NRGW@2323|unclassified Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarboxypepD_reg,TonB_dep_Rec YYD2_k127_5289902_5 1379698.RBG1_1C00001G1246 5.196e-61 220.0 COG0613@1|root,COG0613@2|Bacteria,2NPEX@2323|unclassified Bacteria 2|Bacteria S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP YYD2_k127_5289902_0 1379698.RBG1_1C00001G1247 1.042e-159 519.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria 2|Bacteria E Formiminotransferase-cyclodeaminase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K01746,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N YYD2_k127_5289902_2 1379698.RBG1_1C00001G1248 9.009e-90 306.0 COG1899@1|root,COG1899@2|Bacteria,2NP1S@2323|unclassified Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - YYD2_k127_5289902_3 1379698.RBG1_1C00001G1249 1.143e-71 251.0 COG3170@1|root,COG3170@2|Bacteria,2NPQF@2323|unclassified Bacteria 2|Bacteria NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 YYD2_k127_5289902_8 935948.KE386494_gene822 3.277e-31 128.0 COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia,42GVA@68295|Thermoanaerobacterales 186801|Clostridia T PFAM Protein-tyrosine phosphatase, low molecular weight ywlE - 3.1.3.48,3.9.1.2 ko:K01104,ko:K20201 - - - - ko00000,ko01000 - - - LMWPc YYD2_k127_5289902_9 589924.Ferp_0857 1.974e-26 117.0 COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,245ZQ@183980|Archaeoglobi 183980|Archaeoglobi J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC YYD2_k127_5289902_1 1379698.RBG1_1C00001G1252 2.453e-120 396.0 COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria 2|Bacteria M Mannose-6-phosphate isomerase manC - 2.7.7.13,5.3.1.8,5.4.2.8 ko:K00971,ko:K01840,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01818,R01819 RC00002,RC00376,RC00408 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS00940 MannoseP_isomer,NTP_transferase YYD2_k127_5289902_6 401526.TcarDRAFT_0365 3.667e-58 214.0 COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,4H2DY@909932|Negativicutes 909932|Negativicutes C Phosphate acetyl/butaryl transferase - - - - - - - - - - - - PTA_PTB YYD2_k127_5289902_7 696369.KI912183_gene960 1.733e-34 138.0 COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,261H7@186807|Peptococcaceae 186801|Clostridia C PFAM Phosphate acetyl butaryl transferase ptb2 - 2.3.1.19 ko:K00634 ko00650,ko01100,map00650,map01100 - R01174 RC00004,RC02816 ko00000,ko00001,ko01000 - - - PTA_PTB YYD2_k127_5324191_19 1379698.RBG1_1C00001G1786 3.759e-05 52.0 2CUTJ@1|root,32SW3@2|Bacteria,2NRD1@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5324191_3 1379698.RBG1_1C00001G1787 6.437e-159 541.0 COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria,2NPRE@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - DUF1863,PQQ_2 YYD2_k127_5324191_6 1379698.RBG1_1C00001G1788 2.613e-128 441.0 COG2067@1|root,COG3292@1|root,COG2067@2|Bacteria,COG3292@2|Bacteria,2NPQZ@2323|unclassified Bacteria 2|Bacteria I Two component regulator propeller - - - - - - - - - - - - CHB_HEX_C_1,Reg_prop,Reprolysin_5,VCBS YYD2_k127_5324191_1 1379698.RBG1_1C00001G1789 1.123e-236 779.0 COG1572@1|root,COG1572@2|Bacteria,2NP03@2323|unclassified Bacteria 2|Bacteria S Propeptide_C25 porU - - - - - - - - - - - Peptidase_C25 YYD2_k127_5324191_20 1115512.EH105704_01_03870 0.0001926 51.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,3XMD1@561|Escherichia 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis protein II tar GO:0001101,GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006935,GO:0007154,GO:0007165,GO:0007172,GO:0008150,GO:0009593,GO:0009605,GO:0009719,GO:0009893,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010604,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032101,GO:0032268,GO:0032270,GO:0032991,GO:0034622,GO:0038023,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0043200,GO:0043424,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051606,GO:0051716,GO:0060089,GO:0060255,GO:0065003,GO:0065007,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0071944,GO:0080090,GO:0098561,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901873,GO:1901875 - ko:K03406,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,TarH YYD2_k127_5324191_4 869210.Marky_1642 1.03e-156 507.0 COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E PFAM aromatic amino acid beta-eliminating lyase threonine aldolase tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase YYD2_k127_5324191_12 1379698.RBG1_1C00001G1794 2.744e-80 281.0 COG4448@1|root,COG4448@2|Bacteria 2|Bacteria E L-asparaginase II ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase_II YYD2_k127_5324191_15 313624.NSP_26320 2.509e-49 194.0 COG0318@1|root,COG0318@2|Bacteria,1G3MS@1117|Cyanobacteria,1HIUD@1161|Nostocales 1117|Cyanobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding YYD2_k127_5324191_11 1379698.RBG1_1C00001G0247 1.582e-81 284.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity - - - - - - - - - - - - SpoIIE YYD2_k127_5324191_13 240015.ACP_0849 1.476e-65 235.0 COG0702@1|root,COG0702@2|Bacteria,3Y644@57723|Acidobacteria,2JKJ0@204432|Acidobacteriia 204432|Acidobacteriia GM NmrA-like family - - - - - - - - - - - - NmrA YYD2_k127_5324191_9 1121422.AUMW01000003_gene848 3.107e-90 305.0 COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,249MP@186801|Clostridia,260KG@186807|Peptococcaceae 186801|Clostridia C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig YYD2_k127_5324191_10 565033.GACE_2119 1.262e-88 306.0 COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,245UY@183980|Archaeoglobi 183980|Archaeoglobi C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA YYD2_k127_5324191_14 497964.CfE428DRAFT_3991 3.271e-59 217.0 2CAZH@1|root,2Z7RU@2|Bacteria,46SY1@74201|Verrucomicrobia 74201|Verrucomicrobia - - sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt YYD2_k127_5324191_0 316274.Haur_1733 0.0 1030.0 COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia 32061|Chloroflexia C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C YYD2_k127_5324191_7 1121920.AUAU01000004_gene645 2.398e-116 379.0 COG0479@1|root,COG0479@2|Bacteria,3Y3XR@57723|Acidobacteria 57723|Acidobacteria C 2Fe-2S iron-sulfur cluster binding domain - - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_7,Fer4_8 YYD2_k127_5324191_8 1183438.GKIL_3353 5.186e-102 342.0 COG2008@1|root,COG2008@2|Bacteria,1G4PN@1117|Cyanobacteria 1117|Cyanobacteria E Threonine aldolase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase YYD2_k127_5324191_18 378806.STAUR_7588 4.62e-16 79.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WQ3M@28221|Deltaproteobacteria,2Z1Q1@29|Myxococcales 28221|Deltaproteobacteria K Cold-shock protein cspE - - ko:K03704 - - - - ko00000,ko03000 - - - CSD YYD2_k127_5324191_16 1379698.RBG1_1C00001G0464 4.333e-41 160.0 COG0170@1|root,COG0170@2|Bacteria,2NQ5M@2323|unclassified Bacteria 2|Bacteria I dolichyl monophosphate biosynthetic process sec59 - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf YYD2_k127_5324191_17 1191523.MROS_0172 1.622e-19 103.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity - - 5.2.1.8 ko:K03769,ko:K03771 - - - - ko00000,ko01000,ko03110 - - - OmpA,Rotamase,Rotamase_2,Rotamase_3 YYD2_k127_5324191_5 1379698.RBG1_1C00001G1740 3.119e-135 449.0 COG3852@1|root,COG3852@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9 YYD2_k127_5324191_2 1379698.RBG1_1C00001G1741 9.305e-178 564.0 COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria 2|Bacteria U Type II secretion system (T2SS), protein F pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF YYD2_k127_5325134_1 204669.Acid345_4396 1.592e-23 103.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia 204432|Acidobacteriia KLT Tetratricopeptide repeats - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C YYD2_k127_5325134_0 1122179.KB890421_gene2565 8.766e-37 157.0 COG3210@1|root,COG5295@1|root,COG3210@2|Bacteria,COG5295@2|Bacteria,4PM4Q@976|Bacteroidetes 976|Bacteroidetes UW domain, Protein - - - - - - - - - - - - Peptidase_S74,YadA_head YYD2_k127_5325134_2 1499967.BAYZ01000080_gene910 2.875e-14 86.0 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - - - - - - - - - - - Big_5,ESPR,LVIVD,YadA_anchor,YadA_head,YadA_stalk YYD2_k127_5325134_3 1128421.JAGA01000003_gene3126 1.113e-09 70.0 COG0457@1|root,COG0457@2|Bacteria,2NPK1@2323|unclassified Bacteria 2|Bacteria T Tetratricopeptide repeat - - - - - - - - - - - - Sulfatase,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 YYD2_k127_5335293_0 1232437.KL662013_gene1359 6.16e-20 104.0 COG4775@1|root,COG5616@1|root,COG4775@2|Bacteria,COG5616@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD2_k127_5335293_1 1122176.KB903569_gene3495 0.000752 48.0 COG2931@1|root,COG3291@1|root,COG3591@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3591@2|Bacteria,4NG2K@976|Bacteroidetes,1IY1U@117747|Sphingobacteriia 976|Bacteroidetes E Belongs to the peptidase S1B family - - 3.4.21.50 ko:K01337 - - - - ko00000,ko01000,ko01002 - - - P_proprotein,Trypsin_2 YYD2_k127_5340178_5 1144275.COCOR_01809 3.039e-62 230.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria,2Z0T8@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase YYD2_k127_5340178_3 1254432.SCE1572_26550 1.271e-75 262.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,42RCM@68525|delta/epsilon subdivisions,2WN89@28221|Deltaproteobacteria,2YVX5@29|Myxococcales 28221|Deltaproteobacteria K LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg YYD2_k127_5340178_2 313606.M23134_00255 3.281e-118 404.0 COG3291@1|root,COG3291@2|Bacteria,4PKTY@976|Bacteroidetes,47RAA@768503|Cytophagia 976|Bacteroidetes M ASPIC and UnbV - - - - - - - - - - - - PKD,UnbV_ASPIC,VCBS YYD2_k127_5340178_8 448385.sce3551 2.573e-17 96.0 COG1520@1|root,COG5276@1|root,COG1520@2|Bacteria,COG5276@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - 1.1.2.6 ko:K05889 - - R03136 - ko00000,ko01000 - - - DUF1863,PQQ_2,SLH,TSP_3 YYD2_k127_5340178_1 1379270.AUXF01000002_gene1557 7.08e-232 746.0 COG2091@1|root,COG2091@2|Bacteria,1ZUQA@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - YYD2_k127_5340178_7 1121904.ARBP01000011_gene1396 4.98e-20 105.0 COG1404@1|root,COG1572@1|root,COG3291@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,COG3291@2|Bacteria,4NF1M@976|Bacteroidetes,47NC9@768503|Cytophagia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 YYD2_k127_5340178_4 404380.Gbem_0798 2.421e-67 250.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42NXX@68525|delta/epsilon subdivisions 1224|Proteobacteria NT methyl-accepting chemotaxis protein difA - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal YYD2_k127_5340178_9 1265503.KB905181_gene3773 1.699e-11 72.0 2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,1SDBT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4154) - - - - - - - - - - - - DUF4154 YYD2_k127_5340178_0 404380.Gbem_0683 1.267e-311 992.0 COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,42MZ1@68525|delta/epsilon subdivisions,2WMHA@28221|Deltaproteobacteria,43U2K@69541|Desulfuromonadales 28221|Deltaproteobacteria G PFAM alpha amylase catalytic region - - - - - - - - - - - - Alpha-amylase YYD2_k127_5340178_6 865937.Gilli_1211 4.521e-22 100.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,1HZ2Z@117743|Flavobacteriia,2P5XT@244698|Gillisia 976|Bacteroidetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 YYD2_k127_535802_2 1121935.AQXX01000120_gene4879 5.056e-08 62.0 2EGQV@1|root,33AH0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_535802_1 316274.Haur_1551 6.191e-23 109.0 COG1496@1|root,COG1496@2|Bacteria,2G6N5@200795|Chloroflexi 200795|Chloroflexi S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 YYD2_k127_535802_0 219305.MCAG_05245 1.293e-132 430.0 COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4DAXK@85008|Micromonosporales 201174|Actinobacteria EK Cystathionine beta-synthase - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP YYD2_k127_5374567_11 1225184.ALXE01000044_gene627 2.608e-22 113.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,3VXUG@53335|Pantoea 1236|Gammaproteobacteria P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB btuB GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696 Plug,TonB_dep_Rec YYD2_k127_5374567_13 1123054.KB907709_gene788 9.447e-10 65.0 2FA2R@1|root,342BQ@2|Bacteria,1NZGH@1224|Proteobacteria,1SQPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_5374567_4 448385.sce3387 2.966e-78 285.0 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - YYD2_k127_5374567_0 926569.ANT_27030 7.459e-163 536.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi 200795|Chloroflexi EU PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 YYD2_k127_5374567_2 379066.GAU_2797 1.976e-104 367.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C YYD2_k127_5374567_12 195105.CN97_02185 1.353e-16 94.0 COG2244@1|root,COG2244@2|Bacteria,1N3BW@1224|Proteobacteria,2UE08@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Membrane protein involved in the export of O-antigen and teichoic - - - - - - - - - - - - Polysacc_synt_3 YYD2_k127_5374567_14 118173.KB235914_gene4149 7.868e-07 62.0 COG0457@1|root,COG0457@2|Bacteria,1G1UY@1117|Cyanobacteria 1117|Cyanobacteria S Alternative locus ID - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8 YYD2_k127_5374567_5 1379698.RBG1_1C00001G1355 3.122e-78 270.0 COG0811@1|root,COG0811@2|Bacteria,2NPUZ@2323|unclassified Bacteria 2|Bacteria U MotA/TolQ/ExbB proton channel family exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB YYD2_k127_5374567_8 1379698.RBG1_1C00001G1356 6.533e-37 145.0 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein exbD1 - - - - - - - - - - - ExbD YYD2_k127_5374567_9 1379698.RBG1_1C00001G1357 1.665e-32 134.0 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein exbD2 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD YYD2_k127_5374567_6 1379698.RBG1_1C00001G1358 1.694e-46 177.0 COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C YYD2_k127_5374567_10 1379698.RBG1_1C00001G1358 1.349e-25 115.0 COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C YYD2_k127_5374567_7 984262.SGRA_3562 4.928e-41 172.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1IYS6@117747|Sphingobacteriia 976|Bacteroidetes S cellulase activity - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 YYD2_k127_5374567_3 56780.SYN_01854 2.753e-104 371.0 COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,42TK8@68525|delta/epsilon subdivisions,2WQUX@28221|Deltaproteobacteria 28221|Deltaproteobacteria L helicase superfamily c-terminal domain - - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,Helicase_C YYD2_k127_5374567_1 246194.CHY_0330 2.43e-133 449.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,42FKN@68295|Thermoanaerobacterales 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C YYD2_k127_5386834_1 1379698.RBG1_1C00001G1765 2.24e-127 417.0 COG0438@1|root,COG0438@2|Bacteria,2NNTN@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferases group 1 bshA GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 YYD2_k127_5386834_2 1379698.RBG1_1C00001G1766 3.222e-102 352.0 COG4365@1|root,COG4365@2|Bacteria,2NP8Q@2323|unclassified Bacteria 2|Bacteria S Bacillithiol biosynthesis BshC bshC - - ko:K22136 - - - - ko00000 - - - BshC YYD2_k127_5386834_0 1121428.DESHY_110474___1 4.116e-256 825.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,263ZP@186807|Peptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran YYD2_k127_5386834_4 1182590.BN5_01997 2.085e-34 145.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1YFG5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 YYD2_k127_5386834_5 944481.JAFP01000001_gene393 4.047e-26 123.0 COG1538@1|root,COG1538@2|Bacteria,1PTZ6@1224|Proteobacteria,42RK2@68525|delta/epsilon subdivisions,2WNMB@28221|Deltaproteobacteria,2M70F@213113|Desulfurellales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP YYD2_k127_5386834_6 935948.KE386495_gene1155 3.157e-13 78.0 COG1309@1|root,COG1309@2|Bacteria,1TRSH@1239|Firmicutes,25B0B@186801|Clostridia,42GEJ@68295|Thermoanaerobacterales 186801|Clostridia K regulator, TetR-like, DNA-binding, bacterial archaeal - - - - - - - - - - - - TetR_C_4,TetR_N YYD2_k127_5386834_3 2325.TKV_c18590 2.893e-62 226.0 COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,24DE3@186801|Clostridia,42F3P@68295|Thermoanaerobacterales 186801|Clostridia P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA YYD2_k127_5386883_0 357808.RoseRS_2786 2.707e-69 263.0 COG1520@1|root,COG1520@2|Bacteria,2G9GE@200795|Chloroflexi,3774I@32061|Chloroflexia 32061|Chloroflexia S amine dehydrogenase activity - - - - - - - - - - - - - YYD2_k127_5386883_2 1174504.AJTN02000249_gene792 4.547e-43 176.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4HA13@91061|Bacilli,1ZCMB@1386|Bacillus 91061|Bacilli E Aminotransferase aspB GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 ko:K00812,ko:K22457 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052 RC00006,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_5386883_1 352165.HMPREF7215_1749 2.783e-47 180.0 COG3579@1|root,COG3579@2|Bacteria 2|Bacteria E homocysteine catabolic process pepC GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006508,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009056,GO:0009063,GO:0009636,GO:0009987,GO:0016054,GO:0016787,GO:0019538,GO:0019752,GO:0042221,GO:0043170,GO:0043418,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0050667,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.4.22.40 ko:K01372 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C1_2 YYD2_k127_5396098_0 1183438.GKIL_3722 1.14e-230 733.0 COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N YYD2_k127_5396877_17 1452718.JBOY01000190_gene845 1.909e-25 114.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD2_k127_5396877_20 997346.HMPREF9374_1390 8.397e-14 82.0 COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,4HBB4@91061|Bacilli,27B73@186824|Thermoactinomycetaceae 91061|Bacilli L DNA polymerase III, delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta YYD2_k127_5396877_13 1379698.RBG1_1C00001G1208 7.812e-39 149.0 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion mshB - - ko:K02456,ko:K02650,ko:K10924,ko:K10925 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - N_methyl,Pilin,T2SSG YYD2_k127_5396877_15 1379698.RBG1_1C00001G1208 1.132e-29 126.0 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion mshB - - ko:K02456,ko:K02650,ko:K10924,ko:K10925 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - N_methyl,Pilin,T2SSG YYD2_k127_5396877_1 1379698.RBG1_1C00001G1210 8.35e-171 548.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family nla19 - - ko:K02667,ko:K07713,ko:K07714,ko:K19641 ko02020,map02020 M00499,M00500,M00501,M00772 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_5396877_5 1307436.PBF_09932 1.551e-89 302.0 COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,4HFED@91061|Bacilli,1ZAXA@1386|Bacillus 91061|Bacilli S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 YYD2_k127_5396877_3 1379698.RBG1_1C00001G1216 4.11e-97 331.0 COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria 2|Bacteria H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D YYD2_k127_5396877_14 1379698.RBG1_1C00001G1213 6.732e-37 144.0 COG1956@1|root,COG1956@2|Bacteria,2NPKF@2323|unclassified Bacteria 2|Bacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. yebR - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 YYD2_k127_5396877_4 1337936.IJ00_19060 3.518e-91 308.0 COG0412@1|root,COG0412@2|Bacteria,1G4HV@1117|Cyanobacteria,1HMQR@1161|Nostocales 1117|Cyanobacteria Q dienelactone hydrolase - - - - - - - - - - - - DLH YYD2_k127_5396877_9 880072.Desac_0212 1.182e-61 216.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,2MRIV@213462|Syntrophobacterales 28221|Deltaproteobacteria M Large-conductance mechanosensitive channel, MscL mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL YYD2_k127_5396877_18 1305836.AXVE01000012_gene42 2.057e-21 97.0 COG0346@1|root,COG0346@2|Bacteria,1W3B2@1239|Firmicutes,4I26F@91061|Bacilli,26HZ5@186818|Planococcaceae 91061|Bacilli E lactoylglutathione lyase activity - - - - - - - - - - - - - YYD2_k127_5396877_7 926556.Echvi_0018 7.608e-63 223.0 COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,47PDZ@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA,PD40 YYD2_k127_5396877_2 91464.S7335_4653 1.15e-158 512.0 COG1252@1|root,COG1252@2|Bacteria,1G20T@1117|Cyanobacteria,1GZB9@1129|Synechococcus 1117|Cyanobacteria C NADH dehydrogenase ndbA - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 YYD2_k127_5396877_16 765910.MARPU_05215 1.012e-28 130.0 COG0438@1|root,COG0438@2|Bacteria,1R2WM@1224|Proteobacteria,1RY41@1236|Gammaproteobacteria,1X2DS@135613|Chromatiales 135613|Chromatiales M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 YYD2_k127_5396877_8 935863.AWZR01000003_gene2845 2.855e-62 230.0 COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,1RPB8@1236|Gammaproteobacteria,1X7Y9@135614|Xanthomonadales 135614|Xanthomonadales M Glycosyl transferases group 1 - - - ko:K21001 ko02025,map02025 - - - ko00000,ko00001,ko01003 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4 YYD2_k127_5396877_10 304371.MCP_2273 2.121e-50 195.0 arCOG00787@1|root,arCOG00787@2157|Archaea 2157|Archaea L UvrD REP helicase - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C YYD2_k127_5396877_11 566466.NOR53_1056 4.265e-49 184.0 COG1385@1|root,COG1385@2|Bacteria,1NSD3@1224|Proteobacteria,1SKC3@1236|Gammaproteobacteria,1J7U7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - - - - - - - - - - - Methyltrans_RNA YYD2_k127_5396877_12 861299.J421_0909 1.003e-48 181.0 COG2940@1|root,COG2940@2|Bacteria,1ZTR3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - ko:K07117 - - - - ko00000 - - - SET YYD2_k127_5396877_6 880073.Calab_1912 4.55e-73 254.0 COG2518@1|root,COG2518@2|Bacteria,2NP7E@2323|unclassified Bacteria 2|Bacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT YYD2_k127_5396877_0 1519464.HY22_10360 1.325e-189 612.0 COG0154@1|root,COG0154@2|Bacteria,1FDMC@1090|Chlorobi 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase YYD2_k127_5400119_8 945713.IALB_1673 3.974e-60 211.0 COG3185@1|root,COG3185@2|Bacteria 2|Bacteria E 4-Hydroxyphenylpyruvate dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 YYD2_k127_5400119_0 468059.AUHA01000002_gene43 3.337e-205 654.0 COG3186@1|root,COG3186@2|Bacteria,4NEX5@976|Bacteroidetes,1IQDN@117747|Sphingobacteriia 976|Bacteroidetes E Biopterin-dependent aromatic amino acid hydroxylase phhA - 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 - R01795,R07211 RC00490 ko00000,ko00001,ko01000 - - - Biopterin_H YYD2_k127_5400119_10 867845.KI911784_gene3656 5.151e-51 189.0 COG4221@1|root,COG4221@2|Bacteria,2GBSD@200795|Chloroflexi,375PC@32061|Chloroflexia 32061|Chloroflexia S PFAM short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short YYD2_k127_5400119_9 1521187.JPIM01000030_gene1497 1.644e-56 213.0 COG0720@1|root,COG0720@2|Bacteria,2G992@200795|Chloroflexi,3753G@32061|Chloroflexia 32061|Chloroflexia H PFAM 6-pyruvoyl tetrahydropterin synthase and - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS YYD2_k127_5400119_12 880073.Calab_1147 1.05e-17 96.0 COG0720@1|root,COG0720@2|Bacteria,2NR5B@2323|unclassified Bacteria 2|Bacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS YYD2_k127_5400119_6 1117647.M5M_01650 8.382e-80 272.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1J50N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0302 GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI YYD2_k127_5400119_7 1499967.BAYZ01000068_gene1924 6.071e-68 237.0 COG0704@1|root,COG0704@2|Bacteria,2NPWX@2323|unclassified Bacteria 2|Bacteria P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU YYD2_k127_5400119_2 335543.Sfum_2890 2.048e-110 363.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2MR99@213462|Syntrophobacterales 28221|Deltaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran YYD2_k127_5400119_1 404589.Anae109_0420 1.621e-111 368.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,2YVAR@29|Myxococcales 28221|Deltaproteobacteria P Phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 YYD2_k127_5400119_4 404589.Anae109_0419 3.46e-97 327.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2YV6J@29|Myxococcales 28221|Deltaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 YYD2_k127_5400119_5 1131812.JQMS01000001_gene1238 1.199e-81 280.0 COG0226@1|root,COG0226@2|Bacteria,4NJGR@976|Bacteroidetes,1I2BC@117743|Flavobacteriia,2NTPT@237|Flavobacterium 976|Bacteroidetes P PBP superfamily domain pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 YYD2_k127_5400119_3 215803.DB30_0086 9.203e-103 341.0 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria,2YVQ5@29|Myxococcales 28221|Deltaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 YYD2_k127_5400119_11 1278073.MYSTI_05248 5.451e-28 122.0 COG3746@1|root,COG3746@2|Bacteria,1PBWD@1224|Proteobacteria,433TT@68525|delta/epsilon subdivisions,2X3F8@28221|Deltaproteobacteria,2YVU2@29|Myxococcales 28221|Deltaproteobacteria P phosphate-selective porin O and P - - - - - - - - - - - - - YYD2_k127_5404617_2 945713.IALB_2995 3.027e-16 84.0 COG4288@1|root,COG4288@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Amidase_2,Big_5,CHU_C,FlgD_ig,LTD YYD2_k127_5404617_1 1379698.RBG1_1C00001G1870 1.303e-115 385.0 COG0232@1|root,COG0232@2|Bacteria,2NP3S@2323|unclassified Bacteria 2|Bacteria F Phosphohydrolase-associated domain dgt GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc YYD2_k127_5404617_0 1519464.HY22_10360 2.787e-215 682.0 COG0154@1|root,COG0154@2|Bacteria,1FDMC@1090|Chlorobi 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase YYD2_k127_5423499_8 1268622.AVS7_03228 1.146e-85 291.0 COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,2VJHB@28216|Betaproteobacteria,4AHHU@80864|Comamonadaceae 28216|Betaproteobacteria P Cation efflux family - - - - - - - - - - - - Cation_efflux,HMA YYD2_k127_5423499_11 1499967.BAYZ01000050_gene2839 3.511e-36 145.0 COG0640@1|root,COG0640@2|Bacteria,2NQ13@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix, Arsenical Resistance Operon Repressor arsR - 3.6.4.12 ko:K03655,ko:K03892 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - HTH_20,HTH_5 YYD2_k127_5423499_2 525897.Dbac_1904 3.409e-197 622.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2M9VF@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 YYD2_k127_5423499_15 1121918.ARWE01000001_gene2104 3.926e-23 101.0 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,42V0C@68525|delta/epsilon subdivisions,2WRJR@28221|Deltaproteobacteria,43VV1@69541|Desulfuromonadales 28221|Deltaproteobacteria CO Thioredoxin domain - - - - - - - - - - - - Thioredoxin_3 YYD2_k127_5423499_14 1304885.AUEY01000001_gene3204 8.546e-25 109.0 2DPAK@1|root,33193@2|Bacteria,1NDU6@1224|Proteobacteria,432ZD@68525|delta/epsilon subdivisions,2WYIN@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_5423499_9 595460.RRSWK_03132 3.727e-59 212.0 COG0785@1|root,COG0785@2|Bacteria,2J2ZI@203682|Planctomycetes 203682|Planctomycetes O Cytochrome C biogenesis protein transmembrane region - - - - - - - - - - - - DsbD_2 YYD2_k127_5423499_5 489825.LYNGBM3L_30250 9.578e-116 381.0 COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,1H9U9@1150|Oscillatoriales 1117|Cyanobacteria C NADPH quinone reductase - - - - - - - - - - - - ADH_N,ADH_zinc_N_2 YYD2_k127_5423499_0 1125863.JAFN01000001_gene1462 7e-323 1008.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS YYD2_k127_5423499_12 518766.Rmar_2453 4.451e-28 120.0 COG0789@1|root,COG0789@2|Bacteria,4NW77@976|Bacteroidetes,1FK6E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K MerR, DNA binding - - - ko:K19591 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR_1 YYD2_k127_5423499_17 287.DR97_879 1.557e-09 69.0 COG3650@1|root,COG3650@2|Bacteria,1N019@1224|Proteobacteria,1SBAD@1236|Gammaproteobacteria,1YG4W@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S response to hydrogen peroxide - - - ko:K08985 - - - - ko00000 - - - MliC,YscW YYD2_k127_5423499_16 1165096.ARWF01000001_gene2231 2.094e-10 72.0 COG3187@1|root,COG3187@2|Bacteria,1MXIV@1224|Proteobacteria 1224|Proteobacteria O Heat shock protein - - - ko:K03668 - - - - ko00000 - - - META,MliC,YscW YYD2_k127_5423499_13 1408428.JNJP01000016_gene2019 8.728e-26 117.0 COG0726@1|root,COG0726@2|Bacteria,1MY9E@1224|Proteobacteria,42SIV@68525|delta/epsilon subdivisions,2X6KV@28221|Deltaproteobacteria,2MH4A@213115|Desulfovibrionales 28221|Deltaproteobacteria G Protein of unknown function (DUF3298) - - - - - - - - - - - - DUF3298,DUF4163 YYD2_k127_5423499_4 1379698.RBG1_1C00001G1676 4.389e-137 442.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,2NPBE@2323|unclassified Bacteria 2|Bacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR YYD2_k127_5423499_1 313606.M23134_00483 4.463e-198 627.0 COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes,47MZ0@768503|Cytophagia 976|Bacteroidetes E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC YYD2_k127_5423499_10 1121904.ARBP01000006_gene3740 2.589e-38 149.0 COG0457@1|root,COG0457@2|Bacteria,4PBAK@976|Bacteroidetes,47VJ2@768503|Cytophagia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - YYD2_k127_5423499_6 485913.Krac_4939 1.526e-88 299.0 COG2120@1|root,COG2120@2|Bacteria,2G9IP@200795|Chloroflexi 200795|Chloroflexi S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L YYD2_k127_5423499_3 869210.Marky_1927 2.76e-186 595.0 COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E COG0076 Glutamate decarboxylase and related PLP-dependent - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC YYD2_k127_5423499_7 929556.Solca_3116 8.186e-86 302.0 COG1835@1|root,COG1835@2|Bacteria,4NMNZ@976|Bacteroidetes,1IQXU@117747|Sphingobacteriia 976|Bacteroidetes I Domain of unknown function (DUF4153) - - - - - - - - - - - - DUF4153 YYD2_k127_5427218_18 309807.SRU_1197 1.009e-71 254.0 COG1131@1|root,COG1131@2|Bacteria,4NFNM@976|Bacteroidetes 976|Bacteroidetes V ABC transporter yxlF_1 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_5427218_39 309807.SRU_1196 3.345e-13 79.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4 YYD2_k127_5427218_44 1232410.KI421413_gene836 5.935e-05 52.0 COG1633@1|root,COG1633@2|Bacteria,1NEYR@1224|Proteobacteria,42VA3@68525|delta/epsilon subdivisions,2WS93@28221|Deltaproteobacteria,43SR0@69541|Desulfuromonadales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD2_k127_5427218_7 1279009.ADICEAN_01234 1.501e-139 458.0 COG0624@1|root,COG0624@2|Bacteria,4NFGE@976|Bacteroidetes,47JN6@768503|Cytophagia 976|Bacteroidetes E PFAM Peptidase family M20 M25 M40 dapE - - - - - - - - - - - M20_dimer,Peptidase_M20 YYD2_k127_5427218_19 1379270.AUXF01000007_gene866 9.028e-65 231.0 COG1028@1|root,COG1028@2|Bacteria,1ZTIT@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 YYD2_k127_5427218_28 1242864.D187_000455 3.68e-43 169.0 COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,42MGR@68525|delta/epsilon subdivisions,2X5KV@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA YYD2_k127_5427218_30 661478.OP10G_2386 6.595e-32 136.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - Polyketide_cyc2 YYD2_k127_5427218_33 1232410.KI421413_gene835 1.259e-24 110.0 COG1633@1|root,COG1633@2|Bacteria,1RM4Q@1224|Proteobacteria,42SRM@68525|delta/epsilon subdivisions,2WP47@28221|Deltaproteobacteria,43SJC@69541|Desulfuromonadales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD2_k127_5427218_5 340177.Cag_1780 7.567e-156 503.0 COG0205@1|root,COG0205@2|Bacteria,1FEH2@1090|Chlorobi 1090|Chlorobi G PFAM phosphofructokinase - - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK YYD2_k127_5427218_17 1379698.RBG1_1C00001G0422 2.338e-74 255.0 COG0755@1|root,COG0755@2|Bacteria,2NPGT@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmC GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Cytochrom_C_asm YYD2_k127_5427218_36 1379698.RBG1_1C00001G0421 2.41e-21 98.0 COG2332@1|root,COG2332@2|Bacteria,2NQ2A@2323|unclassified Bacteria 2|Bacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE YYD2_k127_5427218_12 1379698.RBG1_1C00001G1882 4.402e-127 436.0 COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm YYD2_k127_5427218_2 880073.Calab_1599 3.246e-163 535.0 COG2864@1|root,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria 2|Bacteria C Cytochrome b subunit of formate dehydrogenase-like protein - - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB YYD2_k127_5427218_27 375286.mma_1306 8.292e-47 176.0 COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,472Y8@75682|Oxalobacteraceae 28216|Betaproteobacteria P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div YYD2_k127_5427218_11 1444712.BN1013_00669 4.788e-128 418.0 COG0306@1|root,COG0306@2|Bacteria,2JH20@204428|Chlamydiae 204428|Chlamydiae P Phosphate transporter family - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 YYD2_k127_5427218_20 439235.Dalk_1431 7.535e-63 224.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WN1U@28221|Deltaproteobacteria,2MICR@213118|Desulfobacterales 28221|Deltaproteobacteria P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU YYD2_k127_5427218_8 1319815.HMPREF0202_01332 1.586e-138 451.0 COG2309@1|root,COG2309@2|Bacteria,379GR@32066|Fusobacteria 32066|Fusobacteria E Thermophilic metalloprotease (M29) - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 YYD2_k127_5427218_24 525146.Ddes_1022 2.424e-52 189.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,42T5Y@68525|delta/epsilon subdivisions,2WNT6@28221|Deltaproteobacteria,2MAZR@213115|Desulfovibrionales 28221|Deltaproteobacteria NT PFAM CheW domain protein - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW YYD2_k127_5427218_21 304371.MCP_2555 8.537e-61 227.0 COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota 28890|Euryarchaeota G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like YYD2_k127_5427218_6 1379698.RBG1_1C00001G1819 9.824e-156 523.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5427218_3 1379698.RBG1_1C00001G1819 2.026e-161 540.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5427218_4 1379698.RBG1_1C00001G1819 1.791e-159 535.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5427218_13 1089550.ATTH01000001_gene1066 3.831e-126 429.0 COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,1FJZ6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD2_k127_5427218_9 639030.JHVA01000001_gene3842 5.053e-135 446.0 COG0612@1|root,COG0612@2|Bacteria,3Y3XF@57723|Acidobacteria,2JHR4@204432|Acidobacteriia 204432|Acidobacteriia S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD2_k127_5427218_14 1444309.JAQG01000164_gene1837 7.801e-124 421.0 COG2304@1|root,COG2304@2|Bacteria,1TSU7@1239|Firmicutes,4HPXN@91061|Bacilli 91061|Bacilli S Domain of unknown function (DUF3520) - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A YYD2_k127_5427218_0 545695.TREAZ_1620 8.757e-276 872.0 COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes 203691|Spirochaetes G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties malP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase YYD2_k127_5427218_10 635013.TherJR_2349 4.53e-132 431.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,2607Y@186807|Peptococcaceae 186801|Clostridia F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA2 - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK YYD2_k127_5427218_15 338963.Pcar_0641 3.031e-93 316.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox YYD2_k127_5427218_23 743719.PaelaDRAFT_3368 9.966e-55 201.0 COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,4HEGP@91061|Bacilli,26TNF@186822|Paenibacillaceae 91061|Bacilli C NAD(P)H-dependent oxidoreductase nfrA - 1.5.1.38 ko:K19285 ko00740,ko01100,map00740,map01100 - R05706 RC00126 ko00000,ko00001,ko01000 - - - Nitroreductase YYD2_k127_5427218_1 251221.35211292 6.882e-218 706.0 COG5549@1|root,COG5549@2|Bacteria,1G2AK@1117|Cyanobacteria 1117|Cyanobacteria O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 YYD2_k127_5427218_16 867845.KI911784_gene362 7.752e-90 334.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - P_proprotein,Peptidase_S8,SLH,fn3 YYD2_k127_5427218_25 502025.Hoch_6859 1.163e-49 181.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,42SRT@68525|delta/epsilon subdivisions,2WPB8@28221|Deltaproteobacteria,2YV8N@29|Myxococcales 28221|Deltaproteobacteria S EVE domain - - - - - - - - - - - - EVE YYD2_k127_5427218_35 1191523.MROS_2238 3.045e-22 113.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - CBM_6,fn3 YYD2_k127_5427218_22 864051.BurJ1DRAFT_3700 1.751e-55 221.0 COG0726@1|root,COG0823@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3420@1|root,COG0726@2|Bacteria,COG0823@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,1MU7T@1224|Proteobacteria,2WI67@28216|Betaproteobacteria,1KMDS@119065|unclassified Burkholderiales 28216|Betaproteobacteria MQU Domain of unknown function (DUF4347) - - - - - - - - - - - - DUF4347 YYD2_k127_5427218_32 880073.Calab_2081 1.192e-26 127.0 COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria 2|Bacteria P LVIVD repeat - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - LVIVD YYD2_k127_5427218_26 880073.Calab_2071 4.529e-49 203.0 COG1361@1|root,COG1404@1|root,COG1520@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG1520@2|Bacteria,2NQX6@2323|unclassified Bacteria 2|Bacteria O SPTR Peptidase S8 and S53 subtilisin kexin sedolisin - - 3.1.3.1 ko:K01113,ko:K14645,ko:K17713 ko00790,ko01100,ko02020,ko02024,map00790,map01100,map02020,map02024 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03110 1.B.33.1 - - PKD,Peptidase_S8,SBBP YYD2_k127_5427218_31 670487.Ocepr_1445 9.268e-31 133.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1WIRD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans YYD2_k127_5427218_42 521011.Mpal_2204 6.079e-08 66.0 COG3291@1|root,arCOG02498@1|root,arCOG02498@2157|Archaea,arCOG02508@2157|Archaea 2157|Archaea G PFAM PKD domain containing protein - - - - - - - - - - - - Beta_helix,NosD,PKD YYD2_k127_5427218_34 8364.ENSXETP00000046997 5.99e-24 118.0 28HX2@1|root,2QQ7Z@2759|Eukaryota,38DFP@33154|Opisthokonta,3BGZ5@33208|Metazoa,3CUDF@33213|Bilateria,482B1@7711|Chordata,496EG@7742|Vertebrata 33208|Metazoa T response to follicle-stimulating hormone PAPPA GO:0000003,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0007565,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016787,GO:0019538,GO:0022414,GO:0031960,GO:0032501,GO:0033993,GO:0042221,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044703,GO:0044706,GO:0046872,GO:0046914,GO:0048545,GO:0050896,GO:0051384,GO:0051704,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.24.79 ko:K07762,ko:K08647 - - - - ko00000,ko01000,ko01002 - - - Laminin_G_3,Notch,Peptidase_M43,Sushi YYD2_k127_5427218_40 448385.sce3663 2.599e-11 75.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - - - - - - - - - - Calx-beta,DUF1194,DUF3616,VPEP,VWA_2 YYD2_k127_5427218_38 509191.AEDB02000035_gene2145 9.44e-20 102.0 2DQWK@1|root,3393J@2|Bacteria,1VT3Z@1239|Firmicutes,24ZUC@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - YYD2_k127_5427218_41 1254432.SCE1572_21525 2.721e-11 76.0 COG1520@1|root,COG2374@1|root,COG1520@2|Bacteria,COG2374@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - ko:K07004 - - - - ko00000 - - - Arylsulfotran_2,Arylsulfotrans,DUF3616,Exo_endo_phos,Hint_2 YYD2_k127_5427218_29 1191523.MROS_1311 1.244e-35 153.0 COG1520@1|root,COG4932@1|root,COG1520@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein - - 3.1.3.1 ko:K01113,ko:K20276 ko00790,ko01100,ko02020,ko02024,map00790,map01100,map02020,map02024 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - DUF11,Gram_pos_anchor YYD2_k127_5427218_37 448385.sce5969 2.722e-21 95.0 COG1409@1|root,COG1409@2|Bacteria,1N7CQ@1224|Proteobacteria,430CA@68525|delta/epsilon subdivisions,2WW6B@28221|Deltaproteobacteria,2YWTS@29|Myxococcales 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 YYD2_k127_5506719_2 580340.Tlie_0418 1.303e-46 173.0 COG2110@1|root,COG2110@2|Bacteria,3TB5Z@508458|Synergistetes 508458|Synergistetes S C-terminal domain of histone - - - - - - - - - - - - Macro YYD2_k127_5506719_1 1379698.RBG1_1C00001G0533 3.423e-118 391.0 COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria 2|Bacteria K acetyltransferase yghO - - - - - - - - - - - Acetyltransf_1 YYD2_k127_5506719_0 1379698.RBG1_1C00001G0532 6.825e-168 538.0 COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria 2|Bacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_5506719_3 1499967.BAYZ01000177_gene5749 8.051e-26 109.0 2DNGD@1|root,32XCZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5506719_4 1159870.KB907784_gene2533 1.405e-14 77.0 COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,2VVXU@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Transglycosylase-associated protein - - - - - - - - - - - - Transgly_assoc YYD2_k127_5546164_0 1232437.KL662013_gene1359 8.418e-15 87.0 COG4775@1|root,COG5616@1|root,COG4775@2|Bacteria,COG5616@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD2_k127_5549882_0 1144313.PMI10_00587 3.271e-38 148.0 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes,1I2T3@117743|Flavobacteriia,2NVZM@237|Flavobacterium 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 YYD2_k127_5549882_1 1254432.SCE1572_32910 8.045e-28 131.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2WJNS@28221|Deltaproteobacteria,2Z3JN@29|Myxococcales 28221|Deltaproteobacteria KLT GAF domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,Pkinase YYD2_k127_5549882_2 335543.Sfum_0853 7.628e-12 72.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MR37@213462|Syntrophobacterales 28221|Deltaproteobacteria K two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_5564362_0 1379698.RBG1_1C00001G1315 5.363e-83 287.0 COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 arnC - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 YYD2_k127_5564362_1 1379698.RBG1_1C00001G0995 1.906e-62 230.0 COG5617@1|root,COG5617@2|Bacteria,2NS5H@2323|unclassified Bacteria 2|Bacteria E Bacterial membrane protein YfhO - - - - - - - - - - - - YfhO YYD2_k127_5565977_11 1280673.AUJJ01000018_gene987 1.256e-18 94.0 COG1011@1|root,COG1011@2|Bacteria,1TPBK@1239|Firmicutes,24EB9@186801|Clostridia,4BXT4@830|Butyrivibrio 186801|Clostridia L HAD-hyrolase-like - - - ko:K07025 - - - - ko00000 - - - HAD_2,NUDIX YYD2_k127_5565977_0 1191523.MROS_2798 0.0 1234.0 COG0574@1|root,COG0574@2|Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_2,PPDK_N,Response_reg YYD2_k127_5565977_9 378806.STAUR_7979 3.27e-41 157.0 2E2RY@1|root,32XUA@2|Bacteria,1N9C1@1224|Proteobacteria,42XP0@68525|delta/epsilon subdivisions,2WT7T@28221|Deltaproteobacteria,2YVJE@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF1579) - - - - - - - - - - - - DUF1579 YYD2_k127_5565977_1 1191523.MROS_2800 1.898e-230 718.0 COG0334@1|root,COG0334@2|Bacteria 2|Bacteria E glutamate dehydrogenase [NAD(P)+] activity gluD GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.gdhA ELFV_dehydrog,ELFV_dehydrog_N YYD2_k127_5565977_7 517418.Ctha_1551 6.678e-90 317.0 COG1524@1|root,COG1524@2|Bacteria 2|Bacteria S mannose-ethanolamine phosphotransferase activity pafA GO:0003674,GO:0003824,GO:0004035,GO:0004346,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0050308,GO:0050309,GO:0098519 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Phosphodiest YYD2_k127_5565977_2 1449126.JQKL01000008_gene293 8.752e-222 701.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,267RV@186813|unclassified Clostridiales 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase YYD2_k127_5565977_4 187303.BN69_0849 2.888e-142 461.0 COG1453@1|root,COG1453@2|Bacteria,1NIR6@1224|Proteobacteria,2U135@28211|Alphaproteobacteria,36ZIH@31993|Methylocystaceae 28211|Alphaproteobacteria S 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 YYD2_k127_5565977_8 557599.MKAN_22965 1.369e-53 192.0 COG0664@1|root,COG0664@2|Bacteria,2IRJW@201174|Actinobacteria 201174|Actinobacteria T COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - cNMP_binding YYD2_k127_5565977_5 247490.KSU1_A0075 5.332e-121 394.0 COG0543@1|root,COG0543@2|Bacteria,2IYBB@203682|Planctomycetes 203682|Planctomycetes C Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - - - - - - - - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 YYD2_k127_5565977_6 518766.Rmar_2589 1.342e-117 383.0 COG1941@1|root,COG1941@2|Bacteria 2|Bacteria C coenzyme F420 hydrogenase activity hoxY - - - - - - - - - - - Oxidored_q6 YYD2_k127_5565977_3 247490.KSU1_A0077 1.981e-188 602.0 COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes 203682|Planctomycetes C Nickel-dependent hydrogenase - - - - - - - - - - - - NiFeSe_Hases YYD2_k127_5565977_10 247490.KSU1_A0078 5.312e-32 130.0 COG0680@1|root,COG0680@2|Bacteria,2J190@203682|Planctomycetes 203682|Planctomycetes C Hydrogenase maturation protease - - - - - - - - - - - - HycI YYD2_k127_5565977_12 335543.Sfum_3405 3.276e-16 84.0 2CEMF@1|root,33GFG@2|Bacteria,1NIQ6@1224|Proteobacteria,42X94@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - YYD2_k127_5589814_1 999419.HMPREF1077_02471 7.203e-50 187.0 COG3579@1|root,COG3579@2|Bacteria,4NJ3J@976|Bacteroidetes,2FMZY@200643|Bacteroidia,22WXZ@171551|Porphyromonadaceae 976|Bacteroidetes M aminopeptidase pepC - 3.4.22.40 ko:K01372 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C1_2 YYD2_k127_5589814_0 926550.CLDAP_04870 3.505e-116 401.0 COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi 200795|Chloroflexi G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH YYD2_k127_5589814_2 1121918.ARWE01000001_gene1797 2.833e-31 142.0 COG1404@1|root,COG1404@2|Bacteria,1QYWU@1224|Proteobacteria,42VXP@68525|delta/epsilon subdivisions,2X7PK@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - YYD2_k127_5616525_6 518766.Rmar_0571 4.243e-25 119.0 COG4485@1|root,COG5617@1|root,COG4485@2|Bacteria,COG5617@2|Bacteria,4NEE5@976|Bacteroidetes,1FIQ3@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Bacterial membrane protein YfhO - - - - - - - - - - - - YfhO YYD2_k127_5616525_1 1379698.RBG1_1C00001G0996 5.307e-108 355.0 COG0463@1|root,COG0463@2|Bacteria,2NS3Y@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 dpm1 - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 YYD2_k127_5616525_4 1206730.BAGA01000184_gene3108 1.664e-34 144.0 COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4FVK3@85025|Nocardiaceae 201174|Actinobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 YYD2_k127_5616525_3 1286171.EAL2_c03820 8.799e-54 202.0 COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,25UW9@186806|Eubacteriaceae 186801|Clostridia M Glycosyl transferase family 4 tagO - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 YYD2_k127_5616525_0 1379698.RBG1_1C00001G0998 2.897e-124 415.0 COG0825@1|root,COG0825@2|Bacteria,2NNVQ@2323|unclassified Bacteria 2|Bacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iJN678.accA ACCA YYD2_k127_5616525_7 868864.Dester_0687 2.057e-15 77.0 COG2835@1|root,COG2835@2|Bacteria,2G4D1@200783|Aquificae 200783|Aquificae S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p YYD2_k127_5616525_2 1379698.RBG1_1C00001G1000 2.104e-59 209.0 COG1762@1|root,COG1762@2|Bacteria,2NPVC@2323|unclassified Bacteria 2|Bacteria G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2 YYD2_k127_5616525_5 1321781.HMPREF1985_02178 4.129e-31 132.0 COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,4H2TV@909932|Negativicutes 909932|Negativicutes M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC YYD2_k127_563742_11 349741.Amuc_0645 2.246e-57 211.0 COG0486@1|root,COG0486@2|Bacteria,46SIQ@74201|Verrucomicrobia,2ITV2@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N YYD2_k127_563742_12 404589.Anae109_2915 1.091e-55 202.0 COG2010@1|root,COG2010@2|Bacteria,1RBTK@1224|Proteobacteria,43AHK@68525|delta/epsilon subdivisions,2X5XT@28221|Deltaproteobacteria,2YVZ8@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c - - - - - - - - - - - - - YYD2_k127_563742_0 330214.NIDE0362 6.481e-184 594.0 COG0445@1|root,COG0445@2|Bacteria,3J0E9@40117|Nitrospirae 40117|Nitrospirae D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc YYD2_k127_563742_19 314232.SKA53_11868 1.26e-09 66.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2U9T9@28211|Alphaproteobacteria,2P95D@245186|Loktanella 28211|Alphaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB YYD2_k127_563742_4 697281.Mahau_2951 4.237e-103 341.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales 186801|Clostridia D PFAM Cobyrinic acid a,c-diamide synthase soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 YYD2_k127_563742_7 521098.Aaci_2940 6.919e-68 241.0 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H9TB@91061|Bacilli,27886@186823|Alicyclobacillaceae 91061|Bacilli K Belongs to the ParB family spo0J GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - HTH_3,KorB,ParBc YYD2_k127_563742_15 484770.UFO1_2322 3.336e-28 124.0 COG0739@1|root,COG0739@2|Bacteria,1TRWJ@1239|Firmicutes 1239|Firmicutes M peptidase - - - - - - - - - - - - G5,LysM,Peptidase_M23 YYD2_k127_563742_16 880073.Calab_0240 2.197e-24 108.0 COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria 2|Bacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin YYD2_k127_563742_2 1379698.RBG1_1C00001G0201 1.581e-149 479.0 COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria 2|Bacteria O ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 YYD2_k127_563742_3 1379698.RBG1_1C00001G0202 3.267e-122 400.0 COG1721@1|root,COG1721@2|Bacteria,2NP6B@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 YYD2_k127_563742_13 653733.Selin_1349 1.11e-49 183.0 COG4843@1|root,COG4843@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 YYD2_k127_563742_17 1382359.JIAL01000001_gene1822 1.945e-16 82.0 2ESJ3@1|root,33K3T@2|Bacteria,3Y8Y6@57723|Acidobacteria,2JNTF@204432|Acidobacteriia 204432|Acidobacteriia S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM YYD2_k127_563742_1 1042163.BRLA_c019800 2.182e-177 575.0 COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,4HA7X@91061|Bacilli,26TZM@186822|Paenibacillaceae 91061|Bacilli E oligoendopeptidase F yjbG - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N YYD2_k127_563742_14 1173024.KI912149_gene5832 3.389e-44 173.0 COG0454@1|root,COG0456@2|Bacteria,1GD5Y@1117|Cyanobacteria,1JHKK@1189|Stigonemataceae 1117|Cyanobacteria K GNAT acetyltransferase - - - - - - - - - - - - Acetyltransf_1,FR47 YYD2_k127_563742_9 330779.Saci_1629 7.946e-64 222.0 COG1839@1|root,arCOG04298@2157|Archaea,2XQ7K@28889|Crenarchaeota 28889|Crenarchaeota L PFAM Adenosine specific kinase - - - ko:K09129 - - - - ko00000 - - - Adenosine_kin YYD2_k127_563742_10 483219.LILAB_31320 8.158e-59 228.0 COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2WWSG@28221|Deltaproteobacteria,2YVBS@29|Myxococcales 28221|Deltaproteobacteria M Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - HEAT_2,Pro_isomerase YYD2_k127_563742_18 1254432.SCE1572_25105 1.389e-10 73.0 2DP1D@1|root,3304P@2|Bacteria,1R5XI@1224|Proteobacteria,4386M@68525|delta/epsilon subdivisions,2X9ZN@28221|Deltaproteobacteria,2YVZY@29|Myxococcales 28221|Deltaproteobacteria S HmuY protein - - - - - - - - - - - - HmuY YYD2_k127_563742_6 1191523.MROS_1425 1.013e-79 293.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD2_k127_563742_5 1379698.RBG1_1C00001G0213 2.159e-80 278.0 COG0059@1|root,COG0059@2|Bacteria,2NNKS@2323|unclassified Bacteria 2|Bacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iHN637.CLJU_RS07505,iIT341.HP0330,iLF82_1304.LF82_1103 IlvC,IlvN YYD2_k127_563742_8 290318.Cvib_0335 8.106e-68 241.0 COG0157@1|root,COG0157@2|Bacteria,1FDAY@1090|Chlorobi 1090|Chlorobi H Belongs to the NadC ModD family - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N YYD2_k127_5663128_0 330214.NIDE1937 0.0 1489.0 COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD YYD2_k127_5663128_8 1519464.HY22_13445 2.202e-102 341.0 COG0109@1|root,COG0109@2|Bacteria 2|Bacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA YYD2_k127_5663128_12 1396418.BATQ01000137_gene3876 6.452e-67 234.0 COG3880@1|root,COG3880@2|Bacteria,46SMN@74201|Verrucomicrobia,2IU6R@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 YYD2_k127_5663128_1 880073.Calab_0311 0.0 1067.0 COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S dicluster domain hybA - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding YYD2_k127_5663128_3 880073.Calab_0310 6.932e-220 690.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 2|Bacteria C Polysulphide reductase, NrfD actC - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD YYD2_k127_5663128_14 518766.Rmar_0224 9.584e-47 174.0 COG2010@1|root,COG2010@2|Bacteria,4NEX9@976|Bacteroidetes,1FJ8P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Protein of unknown function (DUF3341) actD - - - - - - - - - - - DUF3341 YYD2_k127_5663128_11 880073.Calab_0308 7.302e-71 245.0 COG2010@1|root,COG2010@2|Bacteria,2NPQJ@2323|unclassified Bacteria 2|Bacteria C Cytochrome C oxidase, cbb3-type, subunit III actE - - - - - - - - - - - Cytochrome_CBB3 YYD2_k127_5663128_5 1519464.HY22_05025 9.419e-136 442.0 COG4531@1|root,COG4531@2|Bacteria 2|Bacteria P zinc ion transport actF - - - - - - - - - - - - YYD2_k127_5663128_10 518766.Rmar_0228 2.208e-77 269.0 COG1999@1|root,COG1999@2|Bacteria,4NU1J@976|Bacteroidetes,1FJ7I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S signal sequence binding - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC YYD2_k127_5663128_7 880073.Calab_0304 3.381e-123 402.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2NNSH@2323|unclassified Bacteria 2|Bacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275,ko:K17223 ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120 M00155,M00595 R00081,R10151 RC00016,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C YYD2_k127_5663128_2 880073.Calab_0303 1.722e-251 786.0 COG0843@1|root,COG0843@2|Bacteria,2NNTQ@2323|unclassified Bacteria 2|Bacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxA - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 YYD2_k127_5663128_9 880073.Calab_0302 2.375e-89 299.0 COG1845@1|root,COG1845@2|Bacteria,2NPIG@2323|unclassified Bacteria 2|Bacteria C cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 YYD2_k127_5663128_17 880073.Calab_0301 2.463e-24 108.0 2ASAK@1|root,31HPU@2|Bacteria,2NQ6K@2323|unclassified Bacteria 2|Bacteria S Prokaryotic Cytochrome C oxidase subunit IV - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - COX4_pro YYD2_k127_5663128_13 517418.Ctha_2324 5.671e-65 241.0 COG1612@1|root,COG1612@2|Bacteria 2|Bacteria O heme a metabolic process ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA YYD2_k127_5663128_15 880073.Calab_0299 4.097e-44 179.0 COG1999@1|root,COG1999@2|Bacteria,2NQ63@2323|unclassified Bacteria 2|Bacteria O SCO1/SenC ypmQ - - ko:K07152,ko:K08976 - - - - ko00000,ko03029 - - - SCO1-SenC YYD2_k127_5663128_16 880073.Calab_0298 1.649e-43 163.0 COG2322@1|root,COG2322@2|Bacteria 2|Bacteria S membrane yozB - - ko:K07152,ko:K08976 - - - - ko00000,ko03029 - - - DUF420 YYD2_k127_5663128_19 1120968.AUBX01000016_gene1747 2.068e-15 91.0 COG1470@1|root,COG1470@2|Bacteria,4NFPN@976|Bacteroidetes,47M4H@768503|Cytophagia 976|Bacteroidetes S CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 YYD2_k127_5663128_6 1379698.RBG1_1C00001G1670 1.504e-133 439.0 COG1228@1|root,COG1228@2|Bacteria,2NR87@2323|unclassified Bacteria 2|Bacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 YYD2_k127_5663128_4 740709.A10D4_06286 1.699e-140 455.0 COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,1RRK7@1236|Gammaproteobacteria,2QF77@267893|Idiomarinaceae 1236|Gammaproteobacteria Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 YYD2_k127_5663196_3 331869.BAL199_06614 6.679e-18 89.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 YYD2_k127_5663196_1 530564.Psta_0541 6.598e-45 168.0 COG0590@1|root,COG0590@2|Bacteria,2IZCA@203682|Planctomycetes 203682|Planctomycetes FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam YYD2_k127_5663196_0 580340.Tlie_1509 1.526e-49 182.0 COG2077@1|root,COG2077@2|Bacteria,3TAX1@508458|Synergistetes 508458|Synergistetes O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin YYD2_k127_5663196_2 1033802.SSPSH_002909 4.084e-35 134.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C YYD2_k127_5666091_14 1191523.MROS_0982 4.058e-23 111.0 COG4677@1|root,COG4677@2|Bacteria 2|Bacteria G pectinesterase activity - - 3.2.1.51,4.2.2.23 ko:K10297,ko:K15923,ko:K18197 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04121 - GH95,PL11 - Beta_helix,CBM_35,Glyco_hydro_98M YYD2_k127_5666091_1 439235.Dalk_2962 1.557e-125 422.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales 28221|Deltaproteobacteria KLT PFAM Protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding YYD2_k127_5666091_3 1379698.RBG1_1C00001G0304 1.327e-91 308.0 COG0413@1|root,COG0413@2|Bacteria,2NP1G@2323|unclassified Bacteria 2|Bacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf YYD2_k127_5666091_4 880073.Calab_2860 6.689e-65 229.0 COG1428@1|root,COG1428@2|Bacteria,2NPEH@2323|unclassified Bacteria 2|Bacteria F Deoxynucleoside kinase dgk - 2.7.1.113 ko:K15518 ko00230,map00230 - R01967 RC00002,RC00017 ko00000,ko00001,ko01000 - - - HPPK,dNK YYD2_k127_5666091_10 398767.Glov_0375 9.457e-31 127.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2WQ4P@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK YYD2_k127_5666091_13 1379698.RBG1_1C00001G0302 3.754e-26 117.0 COG1539@1|root,COG1539@2|Bacteria,2NQ1A@2323|unclassified Bacteria 2|Bacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB YYD2_k127_5666091_8 1123376.AUIU01000013_gene1914 9.436e-39 159.0 COG0436@1|root,COG0436@2|Bacteria,3J0G2@40117|Nitrospirae 40117|Nitrospirae E Aminotransferase class I and II - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_5666091_5 649747.HMPREF0083_01731 2.797e-53 196.0 COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,4HG91@91061|Bacilli,26TR3@186822|Paenibacillaceae 91061|Bacilli G Aldolase - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II YYD2_k127_5666091_2 1379698.RBG1_1C00001G0597 5.416e-102 351.0 COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria 2|Bacteria O smart pdz dhr glgf degQ - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD2_k127_5666091_0 1379698.RBG1_1C00001G0598 3.635e-141 452.0 COG0568@1|root,COG0568@2|Bacteria,2NNY9@2323|unclassified Bacteria 2|Bacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 YYD2_k127_5666091_6 1329516.JPST01000012_gene28 4.961e-44 173.0 COG5017@1|root,COG5017@2|Bacteria,1V2RT@1239|Firmicutes,4I1HA@91061|Bacilli,27CY8@186824|Thermoactinomycetaceae 91061|Bacilli S D-glucuronyl C5-epimerase C-terminus - - - - - - - - - - - - C5-epim_C YYD2_k127_5666091_15 1123057.P872_13040 4.878e-15 79.0 2EEZ4@1|root,30XX1@2|Bacteria,4PBHB@976|Bacteroidetes,47VW5@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_5666091_7 1227739.Hsw_0573 1.655e-42 162.0 2E3VP@1|root,32YSV@2|Bacteria,4NV28@976|Bacteroidetes,47S3V@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_5666091_11 1094466.KQS_07925 4.903e-30 123.0 COG0640@1|root,COG0640@2|Bacteria,4NSAV@976|Bacteroidetes,1I3VH@117743|Flavobacteriia,2NWRE@237|Flavobacterium 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - HTH_34 YYD2_k127_5666091_9 1202532.FF52_08179 4.385e-37 147.0 COG3127@1|root,COG3127@2|Bacteria,4NN8S@976|Bacteroidetes,1I1UF@117743|Flavobacteriia,2NVBJ@237|Flavobacterium 976|Bacteroidetes Q membrane - - - - - - - - - - - - - YYD2_k127_5666827_1 1321778.HMPREF1982_00036 1.921e-177 560.0 COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,26881@186813|unclassified Clostridiales 186801|Clostridia EJ Psort location Cytoplasmic, score - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase YYD2_k127_5666827_0 1047013.AQSP01000142_gene242 7.977e-252 793.0 COG2511@1|root,COG2511@2|Bacteria 2|Bacteria J GatB/GatE catalytic domain - - - - - - - - - - - - GatB_N YYD2_k127_5666827_2 1449126.JQKL01000031_gene1144 6.818e-83 284.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,267WS@186813|unclassified Clostridiales 186801|Clostridia I Enoyl-CoA hydratase/isomerase crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 YYD2_k127_5666827_3 697329.Rumal_2962 1.045e-08 59.0 COG1670@1|root,COG1670@2|Bacteria,1V4F3@1239|Firmicutes,24EZ6@186801|Clostridia,3WM79@541000|Ruminococcaceae 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 YYD2_k127_5722662_5 558169.AGAV01000005_gene2069 2.057e-42 160.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli 91061|Bacilli L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C YYD2_k127_5722662_6 1267533.KB906735_gene4737 1.924e-23 106.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 YYD2_k127_5722662_3 502025.Hoch_1468 5.316e-80 277.0 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,42VPN@68525|delta/epsilon subdivisions,2WRK6@28221|Deltaproteobacteria,2Z1WG@29|Myxococcales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA YYD2_k127_5722662_7 391587.KAOT1_10526 4.517e-11 72.0 COG2849@1|root,COG2849@2|Bacteria,4NMDX@976|Bacteroidetes,1I51X@117743|Flavobacteriia 976|Bacteroidetes M PFAM MORN repeat variant - - - - - - - - - - - - MORN_2,TPR_1,TPR_16,TPR_8 YYD2_k127_5722662_4 768704.Desmer_3702 7.177e-53 191.0 COG2318@1|root,COG2318@2|Bacteria,1V8MI@1239|Firmicutes 1239|Firmicutes S PFAM DinB family - - - - - - - - - - - - DinB YYD2_k127_5722662_1 316274.Haur_1687 3.655e-132 428.0 COG0667@1|root,COG0667@2|Bacteria,2G5YU@200795|Chloroflexi,376EH@32061|Chloroflexia 32061|Chloroflexia C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red YYD2_k127_5722662_8 68219.JNXI01000006_gene2065 4.265e-07 61.0 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C YYD2_k127_5722662_0 1379698.RBG1_1C00001G0635 2.738e-158 507.0 COG1089@1|root,COG1089@2|Bacteria,2NNM2@2323|unclassified Bacteria 2|Bacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd YYD2_k127_5722662_2 1379698.RBG1_1C00001G0636 2.339e-80 279.0 COG1089@1|root,COG1089@2|Bacteria,2NP6U@2323|unclassified Bacteria 2|Bacteria M Polysaccharide biosynthesis protein wcbK - 1.1.1.281,4.2.1.47 ko:K01711,ko:K15856 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888,R03397,R03399 RC00182,RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd YYD2_k127_5722662_9 1179778.PMM47T1_16038 4.913e-05 47.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wbpA - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N YYD2_k127_5728320_1 1123054.KB907706_gene2275 6.124e-172 563.0 COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,1RRK7@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 YYD2_k127_5728320_0 933262.AXAM01000063_gene622 5.325e-245 772.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,42P5R@68525|delta/epsilon subdivisions,2WJDU@28221|Deltaproteobacteria,2MI4P@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM AMP-dependent synthetase and ligase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C YYD2_k127_5728320_4 945713.IALB_1670 7.033e-108 360.0 COG1853@1|root,COG1853@2|Bacteria 2|Bacteria S FMN binding - - - - - - - - - - - - Flavin_Reduct YYD2_k127_5728320_3 945713.IALB_1671 2.126e-131 428.0 COG0179@1|root,COG0179@2|Bacteria 2|Bacteria Q Fumarylacetoacetate (FAA) hydrolase fahA2 - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase YYD2_k127_5728320_6 234267.Acid_4166 3.287e-96 327.0 COG0079@1|root,COG0079@2|Bacteria,3Y4H9@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_5728320_2 945713.IALB_1672 5.909e-168 535.0 COG3508@1|root,COG3508@2|Bacteria 2|Bacteria Q Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate hmgA - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA YYD2_k127_5728320_5 945713.IALB_1673 4.495e-104 343.0 COG3185@1|root,COG3185@2|Bacteria 2|Bacteria E 4-Hydroxyphenylpyruvate dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 YYD2_k127_5759805_0 880073.Calab_3167 2.583e-130 442.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec YYD2_k127_5759805_4 311424.DhcVS_273 3.791e-83 285.0 COG0053@1|root,COG0053@2|Bacteria,2G5MK@200795|Chloroflexi,34CPI@301297|Dehalococcoidia 301297|Dehalococcoidia P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer YYD2_k127_5759805_2 1123508.JH636449_gene7422 3.588e-112 410.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg YYD2_k127_5759805_3 273068.TTE2746 6.445e-86 305.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,24A6D@186801|Clostridia,42J4J@68295|Thermoanaerobacterales 186801|Clostridia C Best Blastp hit gi 7462068 pir H72266 astB chuR-related protein - Thermotoga maritima (strain MSB8) gi 4981883 gb AAD36396.1 AE001787_1 (AE001787) astB chuR-related protein Thermotoga maritima , score - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM YYD2_k127_5759805_5 203119.Cthe_0533 1.829e-80 282.0 COG0457@1|root,COG0535@1|root,COG0457@2|Bacteria,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,3WHA6@541000|Ruminococcaceae 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM YYD2_k127_5759805_1 1304880.JAGB01000002_gene1563 1.292e-114 391.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran YYD2_k127_5767256_0 1121904.ARBP01000033_gene3216 8.083e-89 315.0 COG5002@1|root,COG5002@2|Bacteria,4PKBV@976|Bacteroidetes,47MII@768503|Cytophagia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA YYD2_k127_5767256_1 1237149.C900_04521 8.232e-27 111.0 COG0745@1|root,COG0745@2|Bacteria,4NM5Q@976|Bacteroidetes,47PED@768503|Cytophagia 976|Bacteroidetes K Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C YYD2_k127_578666_0 1123288.SOV_6c01980 1.86e-130 435.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4H28C@909932|Negativicutes 909932|Negativicutes L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C YYD2_k127_5797172_0 204669.Acid345_4736 6.229e-92 306.0 COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria,2JHV7@204432|Acidobacteriia 204432|Acidobacteriia J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD YYD2_k127_5797172_3 558152.IQ37_16325 0.0001104 48.0 COG2010@1|root,COG2010@2|Bacteria,4NXZT@976|Bacteroidetes,1IBNZ@117743|Flavobacteriia,3ZS9T@59732|Chryseobacterium 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C,DHC YYD2_k127_5797172_1 1379698.RBG1_1C00001G1884 1.092e-39 151.0 COG0558@1|root,COG0558@2|Bacteria,2NPJ9@2323|unclassified Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iSB619.SA_RS06365 CDP-OH_P_transf YYD2_k127_5806984_0 452637.Oter_1454 0.0 1261.0 COG0841@1|root,COG0841@2|Bacteria,46SER@74201|Verrucomicrobia 74201|Verrucomicrobia V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran YYD2_k127_5806984_4 1121918.ARWE01000001_gene2983 2.274e-46 184.0 COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2WKAK@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 YYD2_k127_5806984_7 1382306.JNIM01000001_gene3599 4.9e-20 99.0 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - - - - - - - - - - HTH_20,HTH_5 YYD2_k127_5806984_1 1047013.AQSP01000130_gene1864 2.394e-202 640.0 COG0591@1|root,COG0591@2|Bacteria,2NPAX@2323|unclassified Bacteria 2|Bacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF YYD2_k127_5806984_2 1047013.AQSP01000130_gene1863 3.904e-97 332.0 28KQH@1|root,2ZA8A@2|Bacteria 2|Bacteria S Alginate export - - - - - - - - - - - - Alginate_exp YYD2_k127_5806984_6 28072.Nos7524_0700 1.477e-43 164.0 COG4405@1|root,COG4405@2|Bacteria,1GE0T@1117|Cyanobacteria 1117|Cyanobacteria S ASCH - - - - - - - - - - - - ASCH YYD2_k127_5806984_5 1047013.AQSP01000093_gene14 4.866e-44 162.0 COG2920@1|root,COG2920@2|Bacteria,2NQ6I@2323|unclassified Bacteria 2|Bacteria P DsrC like protein dsrC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC YYD2_k127_5806984_8 246194.CHY_2401 3.605e-11 67.0 COG2181@1|root,COG2181@2|Bacteria 2|Bacteria C nitrate reductase activity - - - - - - - - - - - - SLAC1 YYD2_k127_5854054_34 459349.CLOAM0028 7.072e-11 65.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_5854054_15 1379698.RBG1_1C00001G0884 1.377e-95 327.0 COG2182@1|root,COG2182@2|Bacteria 2|Bacteria G maltose binding - - - ko:K02027,ko:K17329 ko02010,map02010 M00207,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.33 - - SBP_bac_1,SBP_bac_8 YYD2_k127_5854054_20 1379698.RBG1_1C00001G0883 1.772e-82 283.0 COG1175@1|root,COG1175@2|Bacteria,2NPDA@2323|unclassified Bacteria 2|Bacteria G binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 YYD2_k127_5854054_19 1379698.RBG1_1C00001G0882 4.383e-83 286.0 COG0395@1|root,COG0395@2|Bacteria,2NPFW@2323|unclassified Bacteria 2|Bacteria U binding-protein-dependent transport systems inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 YYD2_k127_5854054_31 1123033.ARNF01000067_gene611 2.674e-17 89.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,3NKBN@468|Moraxellaceae 1236|Gammaproteobacteria M Belongs to the ompA family pal GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032153,GO:0044425,GO:0044462,GO:0044464,GO:0051301,GO:0071944,GO:0098552 - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA YYD2_k127_5854054_26 1519464.HY22_03435 4.516e-33 146.0 COG2372@1|root,COG2372@2|Bacteria,1FE0C@1090|Chlorobi 1090|Chlorobi S Bacterial Ig-like domain - - - - - - - - - - - - Big_5 YYD2_k127_5854054_23 1379698.RBG1_1C00001G1338 1.18e-62 235.0 COG0457@1|root,COG0457@2|Bacteria,2NPEN@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 YYD2_k127_5854054_12 945713.IALB_1745 2.194e-133 438.0 COG0162@1|root,COG0162@2|Bacteria 2|Bacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436,iLJ478.TM0478 S4,tRNA-synt_1b YYD2_k127_5854054_3 1379698.RBG1_1C00001G1562 1.05e-220 705.0 COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria 2|Bacteria M Transglycosylase mrcA GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase YYD2_k127_5854054_36 223283.PSPTO_4335 3.851e-08 60.0 2ATRU@1|root,31JAM@2|Bacteria,1QH20@1224|Proteobacteria,1TEJU@1236|Gammaproteobacteria,1Z7TF@136849|Pseudomonas syringae group 1236|Gammaproteobacteria - - - - - - - - - - - - - - PilZ YYD2_k127_5854054_6 929556.Solca_1648 1.16e-165 542.0 COG0265@1|root,COG0265@2|Bacteria,4PNUK@976|Bacteroidetes,1IRYS@117747|Sphingobacteriia 976|Bacteroidetes O Peptide-N-glycosidase F, C terminal - - - - - - - - - - - - Laminin_G_3,N-glycanase_C YYD2_k127_5854054_29 1191523.MROS_0980 8.67e-26 126.0 COG3534@1|root,COG3534@2|Bacteria 2|Bacteria G alpha-L-arabinofuranosidase abfA - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C YYD2_k127_5854054_1 661478.OP10G_0991 2.689e-291 940.0 COG0383@1|root,COG0383@2|Bacteria 2|Bacteria G mannose metabolic process - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,F5_F8_type_C,Glyco_hydro_38,Glyco_hydro_38C YYD2_k127_5854054_13 497964.CfE428DRAFT_6304 3.062e-128 425.0 COG1172@1|root,COG1172@2|Bacteria,46V1Z@74201|Verrucomicrobia 74201|Verrucomicrobia G Belongs to the binding-protein-dependent transport system permease family - - - - - - - - - - - - BPD_transp_2 YYD2_k127_5854054_9 313628.LNTAR_12346 4.741e-154 501.0 COG1129@1|root,COG1129@2|Bacteria 2|Bacteria G ABC transporter - - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran YYD2_k127_5854054_21 497964.CfE428DRAFT_6306 8.291e-78 276.0 COG1879@1|root,COG1879@2|Bacteria,46W7Q@74201|Verrucomicrobia 74201|Verrucomicrobia G PFAM periplasmic binding protein LacI transcriptional regulator - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 YYD2_k127_5854054_14 1210884.HG799463_gene9317 6.206e-124 436.0 COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg YYD2_k127_5854054_17 1379698.RBG1_1C00001G0520 6.82e-86 299.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - CHASE2,GAF,GAF_2,HATPase_c_2,SpoIIE YYD2_k127_5854054_40 272123.Anacy_3419 0.0003421 54.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - 3.1.3.1,3.1.3.8,3.1.4.46 ko:K01077,ko:K01083,ko:K01126 ko00562,ko00564,ko00730,ko00790,ko01100,ko02020,map00562,map00564,map00730,map00790,map01100,map02020 M00126 R01030,R01470,R02135,R03371,R04620 RC00017,RC00078,RC00425 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Cadherin,DUF4114,DUF4347,HemolysinCabind,PA14,Phytase-like YYD2_k127_5854054_27 498211.CJA_1292 6.096e-31 142.0 COG2374@1|root,COG3391@1|root,COG5184@1|root,COG2374@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity mtsC - - - - - - - - - - - Big_5,CHU_C,LTD,Reprolysin_4,SLH,TSP_3 YYD2_k127_5854054_38 1382359.JIAL01000001_gene2840 1.819e-06 62.0 COG2706@1|root,COG2931@1|root,COG2706@2|Bacteria,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - 5_nucleotid_C,HemolysinCabind,VCBS YYD2_k127_5854054_11 1379698.RBG1_1C00001G0518 2.45e-135 460.0 COG0515@1|root,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 YYD2_k127_5854054_2 1340493.JNIF01000003_gene2186 5.597e-222 732.0 COG1026@1|root,COG1026@2|Bacteria 2|Bacteria S Peptidase M16C associated - - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C,SLH YYD2_k127_5854054_4 323259.Mhun_0970 8.31e-217 729.0 COG3291@1|root,arCOG02516@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02516@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia 224756|Methanomicrobia O PFAM PKD domain containing protein - - - - - - - - - - - - PKD YYD2_k127_5854054_16 272952.HpaP806918 1.863e-88 304.0 COG0042@1|root,KOG2335@2759|Eukaryota,3QEGX@4776|Peronosporales 4776|Peronosporales J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs - - - - - - - - - - - - Dus YYD2_k127_5854054_8 448385.sce7786 1.742e-159 518.0 COG3104@1|root,COG3104@2|Bacteria,1P6K2@1224|Proteobacteria 1224|Proteobacteria E PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 YYD2_k127_5854054_32 945713.IALB_3128 2.942e-17 95.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - - - - - - - - - - - SGL YYD2_k127_5854054_28 263358.VAB18032_25000 1.886e-27 121.0 COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4DF59@85008|Micromonosporales 201174|Actinobacteria K Belongs to the sigma-70 factor family - - - - - - - - - - - - Sigma70_r2 YYD2_k127_5854054_25 504728.K649_03590 4.621e-41 175.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria 2|Bacteria S CHAT domain - - - - - - - - - - - - CHAT,Haemagg_act,TPR_10,TPR_12,TPR_7,TPR_8 YYD2_k127_5854054_24 509191.AEDB02000022_gene2925 7.422e-45 180.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,3WIT1@541000|Ruminococcaceae 186801|Clostridia O Subtilase family - - - ko:K13274,ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Big_2,Peptidase_S8,SLH YYD2_k127_5854054_7 1379698.RBG1_1C00001G0712 1.096e-159 518.0 COG0612@1|root,COG0612@2|Bacteria,2NQPM@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C YYD2_k127_5854054_10 1379698.RBG1_1C00001G0711 1.263e-137 452.0 COG0612@1|root,COG0612@2|Bacteria,2NQHV@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) ymxG - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C YYD2_k127_5854054_30 1117647.M5M_06390 9.257e-19 98.0 29QWA@1|root,30BWM@2|Bacteria,1REIR@1224|Proteobacteria,1S50N@1236|Gammaproteobacteria,1J7C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - CBM_11,VanZ YYD2_k127_5854054_18 1519464.HY22_01410 2.069e-85 295.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 YYD2_k127_5854054_0 518766.Rmar_0902 0.0 1341.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1FJ61@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_4 - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran YYD2_k127_5854054_22 986075.CathTA2_0103 4.823e-72 249.0 COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,4HDUN@91061|Bacilli 91061|Bacilli S Belongs to the SOS response-associated peptidase family yoqW - - - - - - - - - - - SRAP YYD2_k127_5854054_37 1125863.JAFN01000001_gene275 1.274e-07 62.0 COG3005@1|root,COG3005@2|Bacteria,1NFFE@1224|Proteobacteria,430BS@68525|delta/epsilon subdivisions,2WVRX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 YYD2_k127_5854054_5 1121920.AUAU01000024_gene2388 4.122e-173 582.0 COG3005@1|root,COG3043@1|root,COG3005@2|Bacteria,COG3043@2|Bacteria,3Y4BJ@57723|Acidobacteria 57723|Acidobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 YYD2_k127_5854054_39 1125699.HMPREF9194_00454 1.913e-06 59.0 COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes 203691|Spirochaetes S NHL repeat containing protein - - - - - - - - - - - - NHL,TPR_11 YYD2_k127_5854054_35 404380.Gbem_1116 1.252e-08 66.0 28WYN@1|root,33TG0@2|Bacteria,1NTYC@1224|Proteobacteria,42YTU@68525|delta/epsilon subdivisions,2WU4Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 6 heme-binding sites - - - - - - - - - - - - - YYD2_k127_5854054_33 635013.TherJR_2221 3.162e-11 74.0 COG4409@1|root,COG4733@1|root,COG4409@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - ASH,BNR_2,CBM_35,DUF1080,F5_F8_type_C,PKD YYD2_k127_5895795_0 1121430.JMLG01000001_gene2387 1.638e-277 867.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae 186801|Clostridia H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C YYD2_k127_5895795_1 1499968.TCA2_2767 7.419e-15 90.0 COG1361@1|root,COG2931@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1V4V3@1239|Firmicutes,4HT0D@91061|Bacilli 91061|Bacilli M TIGRFAM conserved repeat domain protein - - - - - - - - - - - - DUF11 YYD2_k127_590147_6 1379698.RBG1_1C00001G0632 1.155e-47 173.0 COG1366@1|root,COG1366@2|Bacteria,2NRCS@2323|unclassified Bacteria 2|Bacteria T STAS domain rsbV - - ko:K04749 - - - - ko00000,ko03021 - - - STAS,STAS_2 YYD2_k127_590147_1 316067.Geob_1970 4.693e-200 643.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,43TM8@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 YYD2_k127_590147_10 316067.Geob_1555 4.172e-18 93.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42T19@68525|delta/epsilon subdivisions,2WQ0M@28221|Deltaproteobacteria,43UV0@69541|Desulfuromonadales 28221|Deltaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - - - - - - - - - - TPR_16,TPR_6 YYD2_k127_590147_8 398767.Glov_3469 2.648e-37 146.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,43UVU@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM OmpA MotB domain protein pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA YYD2_k127_590147_4 443144.GM21_3582 3.991e-81 286.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N YYD2_k127_590147_11 177437.HRM2_30570 1.293e-05 55.0 COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,42XAV@68525|delta/epsilon subdivisions,2WSJJ@28221|Deltaproteobacteria,2MK1A@213118|Desulfobacterales 28221|Deltaproteobacteria M TonB C terminal - - - ko:K03646,ko:K03832 - - - - ko00000,ko02000 2.C.1.1,2.C.1.2 - - TonB_2 YYD2_k127_590147_9 1331060.RLDS_13940 4.03e-23 104.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,2K53V@204457|Sphingomonadales 204457|Sphingomonadales U Biopolymer transport protein tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD YYD2_k127_590147_7 1379698.RBG1_1C00001G0497 6.594e-40 158.0 COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria 2|Bacteria U MotA/TolQ/ExbB proton channel family tolQ - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB YYD2_k127_590147_2 1379698.RBG1_1C00001G0120 7.815e-147 473.0 28II6@1|root,2Z8JB@2|Bacteria,2NNT1@2323|unclassified Bacteria 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - YYD2_k127_590147_0 1379698.RBG1_1C00001G0122 1.988e-297 922.0 COG1070@1|root,COG1070@2|Bacteria,2NP2A@2323|unclassified Bacteria 2|Bacteria G MutL protein - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N,MutL YYD2_k127_590147_3 1379698.RBG1_1C00001G0119 2.771e-114 382.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD2_k127_590147_5 1379698.RBG1_1C00001G0118 1.758e-71 246.0 29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5905362_11 1196322.A370_03232 7.724e-43 164.0 COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,36DRA@31979|Clostridiaceae 186801|Clostridia J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT YYD2_k127_5905362_5 1379698.RBG1_1C00001G1141 8.988e-117 403.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria 2|Bacteria M Transglycosylase SLT domain CP_0155 - - ko:K08307,ko:K12204 - - - - ko00000,ko01000,ko01011,ko02044 3.A.7.10.1,3.A.7.9.1 - - LysM,SLT,T4SS_TraI YYD2_k127_5905362_7 1379698.RBG1_1C00001G1142 1.966e-73 257.0 COG0616@1|root,COG0616@2|Bacteria,2NPIE@2323|unclassified Bacteria 2|Bacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 YYD2_k127_5905362_15 1379698.RBG1_1C00001G1143 1.586e-39 148.0 COG0776@1|root,COG0776@2|Bacteria,2NPU6@2323|unclassified Bacteria 2|Bacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup_1 - - ko:K03530,ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding YYD2_k127_5905362_22 945713.IALB_2216 4.754e-05 45.0 2EIUI@1|root,33CJV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5905362_10 1379698.RBG1_1C00001G0991 2.613e-56 222.0 COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria 2|Bacteria Q FlgD Ig-like domain - - 3.2.1.136 ko:K15924 - - - - ko00000,ko01000 - GH5 - CBM_3,DUF1735,Laminin_G_3 YYD2_k127_5905362_8 313606.M23134_07555 4.209e-64 235.0 295M7@1|root,2ZSYM@2|Bacteria,4NNH9@976|Bacteroidetes,47UGS@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_5905362_19 5911.EAR82286 4.164e-16 89.0 COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora 5878|Ciliophora GOT TPR Domain containing protein - - - ko:K12600 ko03018,map03018 M00392 - - ko00000,ko00001,ko00002,ko03019 - - - TPR_1,TPR_11,TPR_2,TPR_8 YYD2_k127_5905362_14 926567.TheveDRAFT_1038 2.758e-41 157.0 COG0041@1|root,COG0041@2|Bacteria,3TB8R@508458|Synergistetes 508458|Synergistetes F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC YYD2_k127_5905362_2 760568.Desku_1695 3.021e-150 486.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,2609N@186807|Peptococcaceae 186801|Clostridia F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N YYD2_k127_5905362_1 1379698.RBG1_1C00001G1092 1.296e-166 549.0 COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2NPI7@2323|unclassified Bacteria 2|Bacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.4.17.18,3.4.17.22 ko:K05996,ko:K07752 - - - - ko00000,ko01000,ko01002 - - - F5_F8_type_C,Peptidase_M14,Peptidase_M6,Ricin_B_lectin,fn3 YYD2_k127_5905362_4 411464.DESPIG_02784 4.422e-120 400.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_5905362_9 1379698.RBG1_1C00001G1236 1.514e-62 225.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - ko:K06882 - - - - ko00000 - - - fn3 YYD2_k127_5905362_13 1379698.RBG1_1C00001G1235 6.139e-42 173.0 COG1470@1|root,COG1470@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - CarbopepD_reg_2 YYD2_k127_5905362_12 1340493.JNIF01000003_gene4469 4.141e-42 176.0 COG1305@1|root,COG1305@2|Bacteria,3Y3A2@57723|Acidobacteria 57723|Acidobacteria E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core YYD2_k127_5905362_18 240015.ACP_0078 1.016e-19 104.0 COG1305@1|root,COG1305@2|Bacteria,3Y2TK@57723|Acidobacteria,2JHX7@204432|Acidobacteriia 204432|Acidobacteriia E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core YYD2_k127_5905362_6 1379698.RBG1_1C00001G1491 2.084e-101 341.0 COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria 2|Bacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K03705 - - - - ko00000,ko03000 - - - HTH_DeoR,HrcA,HrcA_DNA-bdg YYD2_k127_5905362_17 1280663.ATVR01000029_gene3062 2.789e-34 140.0 COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,4BX70@830|Butyrivibrio 186801|Clostridia O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE YYD2_k127_5905362_0 1379698.RBG1_1C00001G1489 3.638e-296 919.0 COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria 2|Bacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 YYD2_k127_5905362_3 1379698.RBG1_1C00001G1488 1.396e-136 444.0 COG0484@1|root,COG0484@2|Bacteria,2NNNG@2323|unclassified Bacteria 2|Bacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG YYD2_k127_5905362_16 177437.HRM2_11510 2.331e-38 155.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2WIVV@28221|Deltaproteobacteria,2MHQ2@213118|Desulfobacterales 28221|Deltaproteobacteria J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA YYD2_k127_5905362_20 518766.Rmar_1925 1.045e-12 72.0 COG1385@1|root,COG1385@2|Bacteria,4NE2S@976|Bacteroidetes,1FJC7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA YYD2_k127_5905653_0 1449126.JQKL01000038_gene965 1.568e-90 310.0 COG3616@1|root,COG3616@2|Bacteria,1TSES@1239|Firmicutes,24A0X@186801|Clostridia 186801|Clostridia E PFAM Alanine racemase - - - - - - - - - - - - Ala_racemase_N,D-ser_dehydrat YYD2_k127_5905653_2 880073.Calab_0077 2.639e-20 99.0 COG0558@1|root,COG0558@2|Bacteria,2NQ32@2323|unclassified Bacteria 2|Bacteria I CDP-alcohol phosphatidyltransferase pgsA GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf YYD2_k127_5905653_1 880073.Calab_2959 5.239e-54 211.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec YYD2_k127_5906263_2 338969.Rfer_2335 3.567e-130 422.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,4AD4J@80864|Comamonadaceae 28216|Betaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 YYD2_k127_5906263_0 1232437.KL662025_gene929 1.345e-190 603.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42Q4I@68525|delta/epsilon subdivisions,2WKRP@28221|Deltaproteobacteria,2MHRB@213118|Desulfobacterales 28221|Deltaproteobacteria E Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 YYD2_k127_5906263_3 1121918.ARWE01000001_gene2845 5.479e-50 190.0 COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,42QVG@68525|delta/epsilon subdivisions,2WNKA@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA YYD2_k127_5906263_1 517418.Ctha_2056 9.797e-141 462.0 COG0265@1|root,COG0265@2|Bacteria,1FDIE@1090|Chlorobi 1090|Chlorobi O PFAM peptidase S1 and S6, chymotrypsin Hap - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD2_k127_5906263_4 1379698.RBG1_1C00001G0582 1.769e-11 77.0 COG2911@1|root,COG2911@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - - - - - - - - - - - ASH,Cohesin,FlgD_ig,Peptidase_S74 YYD2_k127_5907849_12 571.MC52_17795 5.259e-23 103.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RQAV@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain walR - - - - - - - - - - - Response_reg,Trans_reg_C YYD2_k127_5907849_9 1538644.KO02_18970 1.331e-46 180.0 COG0642@1|root,COG2205@2|Bacteria,4NK58@976|Bacteroidetes,1IPNM@117747|Sphingobacteriia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA YYD2_k127_5907849_10 1379698.RBG1_1C00001G1702 5.563e-45 173.0 COG1595@1|root,COG1595@2|Bacteria,2NR5Q@2323|unclassified Bacteria 2|Bacteria K RNA polymerase sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 YYD2_k127_5907849_11 1008457.BAEX01000035_gene2311 3.127e-40 162.0 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia,47HU4@76831|Myroides 976|Bacteroidetes M Peptidase family M23 mepM_1 - - - - - - - - - - - Peptidase_M23 YYD2_k127_5907849_3 373994.Riv7116_2299 1.05e-92 310.0 COG4221@1|root,COG4221@2|Bacteria,1G182@1117|Cyanobacteria,1HICK@1161|Nostocales 1117|Cyanobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.276 ko:K05886 - - - - ko00000,ko01000 - - - adh_short YYD2_k127_5907849_2 338963.Pcar_0086 2.882e-98 336.0 COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,43S5D@69541|Desulfuromonadales 28221|Deltaproteobacteria P Cation transport protein ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH YYD2_k127_5907849_6 1232410.KI421420_gene3141 1.738e-61 218.0 COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2WMZT@28221|Deltaproteobacteria,43SGD@69541|Desulfuromonadales 28221|Deltaproteobacteria P UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N YYD2_k127_5907849_4 1379698.RBG1_1C00001G0347 1.144e-79 273.0 COG1657@1|root,COG1657@2|Bacteria,2NP7R@2323|unclassified Bacteria 2|Bacteria I Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159,Prenyltrans YYD2_k127_5907849_1 1379698.RBG1_1C00001G0350 1.168e-164 559.0 COG1196@1|root,COG1196@2|Bacteria,2NNSS@2323|unclassified Bacteria 2|Bacteria D nuclear chromosome segregation - - - - - - - - - - - - - YYD2_k127_5907849_7 1379698.RBG1_1C00001G0352 2.786e-60 231.0 COG0457@1|root,COG0457@2|Bacteria,2NRR4@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 YYD2_k127_5907849_0 1379698.RBG1_1C00001G0356 8.232e-180 595.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,2NS3S@2323|unclassified Bacteria 2|Bacteria EG Protein of unknown function (DUF2723) - - - ko:K16928 - M00582 - - ko00000,ko00002,ko02000 3.A.1.33 - - DUF2723,QueT YYD2_k127_5907849_14 1201290.M902_0770 4.177e-15 83.0 COG0640@1|root,COG3860@1|root,COG0640@2|Bacteria,COG3860@2|Bacteria,1N3KK@1224|Proteobacteria,42TH7@68525|delta/epsilon subdivisions,2WQ6A@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Uncharacterized protein conserved in bacteria (DUF2087) - - - - - - - - - - - - DUF2087,GIY-YIG,HTH_20 YYD2_k127_5907849_16 755731.Clo1100_1628 2.68e-05 53.0 2DYSE@1|root,34AX4@2|Bacteria,1VYJA@1239|Firmicutes,24X6H@186801|Clostridia 186801|Clostridia S Helix-turn-helix domain - - - - - - - - - - - - HTH_17 YYD2_k127_5907849_8 1379698.RBG1_1C00001G0519 8.394e-48 182.0 COG0697@1|root,COG0697@2|Bacteria,2NPZZ@2323|unclassified Bacteria 2|Bacteria EG EamA-like transporter family pagO - - ko:K07790 ko02020,map02020 - - - ko00000,ko00001 2.A.7 - - EamA YYD2_k127_5907849_5 1379698.RBG1_1C00001G0988 2.238e-68 247.0 COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria 2|Bacteria C lyase activity - - 3.4.24.3 ko:K01387,ko:K03301 - - - - ko00000,ko01000,ko01002,ko02042 2.A.12 - - DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase YYD2_k127_5919083_27 1379698.RBG1_1C00001G0991 9.231e-22 106.0 COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria 2|Bacteria Q FlgD Ig-like domain - - 3.2.1.136 ko:K15924 - - - - ko00000,ko01000 - GH5 - CBM_3,DUF1735,Laminin_G_3 YYD2_k127_5919083_24 563192.HMPREF0179_03579 3.64e-26 114.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42SII@68525|delta/epsilon subdivisions,2WPJG@28221|Deltaproteobacteria,2MGU2@213115|Desulfovibrionales 28221|Deltaproteobacteria K Belongs to the Fur family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR YYD2_k127_5919083_34 1121287.AUMU01000008_gene2029 1.979e-06 56.0 COG2010@1|root,COG2010@2|Bacteria,4NXZT@976|Bacteroidetes,1IBNZ@117743|Flavobacteriia,3ZS9T@59732|Chryseobacterium 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C,DHC YYD2_k127_5919083_32 1042375.AFPL01000019_gene231 1.563e-12 70.0 COG1918@1|root,COG1918@2|Bacteria,1Q29C@1224|Proteobacteria,1TCA4@1236|Gammaproteobacteria,4694M@72275|Alteromonadaceae 1236|Gammaproteobacteria P FeoA - - - - - - - - - - - - FeoA YYD2_k127_5919083_5 1379270.AUXF01000004_gene3268 2.476e-150 504.0 COG0370@1|root,COG0370@2|Bacteria,1ZT1I@142182|Gemmatimonadetes 142182|Gemmatimonadetes P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate YYD2_k127_5919083_21 1246484.D479_09110 8.851e-46 175.0 COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,4H9VT@91061|Bacilli,3NDE6@45667|Halobacillus 91061|Bacilli U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfT - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ YYD2_k127_5919083_16 1173029.JH980292_gene598 1.443e-52 194.0 COG0101@1|root,COG0101@2|Bacteria,1G263@1117|Cyanobacteria,1H89J@1150|Oscillatoriales 1117|Cyanobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 YYD2_k127_5919083_8 573063.Metin_1349 1.221e-86 292.0 COG0176@1|root,arCOG05061@2157|Archaea,2XTET@28890|Euryarchaeota,23Q23@183939|Methanococci 183939|Methanococci F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA YYD2_k127_5919083_4 404380.Gbem_2333 1.11e-153 500.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,43TS7@69541|Desulfuromonadales 28221|Deltaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 YYD2_k127_5919083_18 56780.SYN_00913 1.652e-51 190.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,42QDS@68525|delta/epsilon subdivisions,2WMQ3@28221|Deltaproteobacteria,2MQID@213462|Syntrophobacterales 28221|Deltaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase YYD2_k127_5919083_12 1379698.RBG1_1C00001G1809 1.178e-68 242.0 COG1183@1|root,COG1183@2|Bacteria,2NPQM@2323|unclassified Bacteria 2|Bacteria I CDP-alcohol phosphatidyltransferase pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf YYD2_k127_5919083_29 1379698.RBG1_1C00001G1808 4.544e-21 95.0 COG1828@1|root,COG1828@2|Bacteria,2NQ45@2323|unclassified Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU06460 PurS YYD2_k127_5919083_7 1121930.AQXG01000010_gene3038 9.274e-98 324.0 COG0047@1|root,COG0047@2|Bacteria,4NFER@976|Bacteroidetes,1IRA4@117747|Sphingobacteriia 976|Bacteroidetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 YYD2_k127_5919083_31 1379698.RBG1_1C00001G1805 5.019e-14 76.0 COG1826@1|root,COG1826@2|Bacteria,2NQ3N@2323|unclassified Bacteria 2|Bacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 YYD2_k127_5919083_20 1379698.RBG1_1C00001G1804 3.315e-48 176.0 2E8AI@1|root,332PD@2|Bacteria,2NRHQ@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_5919083_15 1123508.JH636443_gene5018 4.319e-53 189.0 COG3324@1|root,COG3324@2|Bacteria,2J3W8@203682|Planctomycetes 203682|Planctomycetes S Glyoxalase-like domain - - - ko:K06996 - - - - ko00000 - - - - YYD2_k127_5919083_11 1356852.N008_09000 1.275e-74 270.0 COG1409@1|root,COG3419@1|root,COG1409@2|Bacteria,COG3419@2|Bacteria 2|Bacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - 3.1.3.2 ko:K02674,ko:K14379 ko00740,ko01100,ko04142,ko04380,ko05323,map00740,map01100,map04142,map04380,map05323 - R00548 RC00017 ko00000,ko00001,ko01000,ko02035,ko02044 - - - CarboxypepD_reg,Metallophos,Neisseria_PilC YYD2_k127_5919083_17 1519464.HY22_12335 1.739e-52 203.0 COG4591@1|root,COG4591@2|Bacteria,1FECJ@1090|Chlorobi 1090|Chlorobi M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_5919083_13 580331.Thit_0218 1.054e-60 218.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,42FTY@68295|Thermoanaerobacterales 186801|Clostridia V Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_5919083_0 518766.Rmar_0089 7.296e-215 698.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD2_k127_5919083_3 1379698.RBG1_1C00001G0479 5.47e-160 533.0 COG0515@1|root,COG0515@2|Bacteria 1379698.RBG1_1C00001G0479|- KLT protein kinase activity - - - - - - - - - - - - - YYD2_k127_5919083_14 1499967.BAYZ01000167_gene6734 1.417e-58 212.0 COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria 2|Bacteria T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 YYD2_k127_5919083_10 1379698.RBG1_1C00001G0481 4.686e-85 287.0 COG1716@1|root,COG1716@2|Bacteria,2NQ4X@2323|unclassified Bacteria 2|Bacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - DUF3662,DUF4388,FHA,Yop-YscD_cpl YYD2_k127_5919083_9 1379698.RBG1_1C00001G0485 1.497e-85 293.0 COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria 2|Bacteria C Electron transfer flavoprotein fixB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 ko:K03522,ko:K22432 - - - - ko00000,ko01000,ko04147 - - iAF987.Gmet_2066,iAF987.Gmet_2257 ETF,ETF_alpha,Fer4 YYD2_k127_5919083_30 269797.Mbar_A1802 4.709e-19 101.0 COG1520@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02482@2157|Archaea,arCOG02550@2157|Archaea,arCOG03991@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKV@224756|Methanomicrobia 224756|Methanomicrobia G PQQ-like domain - - - - - - - - - - - - NosD,PKD,PQQ_2,PQQ_3 YYD2_k127_5919083_23 552811.Dehly_0442 2.197e-26 124.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Cytochrom_c3_2 YYD2_k127_5919083_26 1379698.RBG1_1C00001G0488 7.496e-23 115.0 COG4447@1|root,COG4447@2|Bacteria,2NRAH@2323|unclassified Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - CHU_C,Cu_amine_oxidN1,F5_F8_type_C YYD2_k127_5919083_33 880073.Calab_1556 6.341e-12 76.0 COG2067@1|root,COG2067@2|Bacteria,2NR34@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - YYD2_k127_5919083_28 1379698.RBG1_1C00001G0490 2.748e-21 104.0 COG2067@1|root,COG2067@2|Bacteria,2NR8A@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - YYD2_k127_5919083_2 1047013.AQSP01000140_gene2452 4.823e-160 511.0 COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria 2|Bacteria CE Isocitrate/isopropylmalate dehydrogenase dlpA - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh,MoCF_biosynth,RraA-like YYD2_k127_5919083_1 868595.Desca_2668 9.026e-200 638.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae 186801|Clostridia C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C YYD2_k127_5919083_19 1121405.dsmv_2840 6.278e-51 187.0 COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,2MNKA@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase iorB-1 - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR YYD2_k127_5919083_6 1031288.AXAA01000002_gene1383 6.66e-105 352.0 COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae 186801|Clostridia C Belongs to the acetokinase family buk GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase YYD2_k127_5919083_22 857293.CAAU_0252 4.131e-36 144.0 COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,36DC6@31979|Clostridiaceae 186801|Clostridia C phosphate butyryltransferase - - 2.3.1.19 ko:K00634 ko00650,ko01100,map00650,map01100 - R01174 RC00004,RC02816 ko00000,ko00001,ko01000 - - - PTA_PTB YYD2_k127_5979582_0 945713.IALB_1883 3.871e-85 299.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 YYD2_k127_5979582_5 945713.IALB_2217 9.461e-14 80.0 COG0457@1|root,COG0457@2|Bacteria 945713.IALB_2217|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - YYD2_k127_5979582_4 1235800.C819_03197 1.869e-27 121.0 COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,27MSJ@186928|unclassified Lachnospiraceae 186801|Clostridia S ComF family comF - - ko:K02242 - M00429 - - ko00000,ko00002,ko02044 - - - Pribosyltran YYD2_k127_5979582_3 443143.GM18_1697 1.422e-69 246.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,43TES@69541|Desulfuromonadales 28221|Deltaproteobacteria D integrase domain protein SAM domain protein xerD - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase YYD2_k127_5979582_1 1379698.RBG1_1C00001G1343 1.085e-81 284.0 COG2199@1|root,COG2199@2|Bacteria,2NS3Z@2323|unclassified Bacteria 2|Bacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF,HAMP YYD2_k127_5979582_2 1379698.RBG1_1C00001G1339 2.073e-78 274.0 COG1297@1|root,COG1297@2|Bacteria,2NP0C@2323|unclassified Bacteria 2|Bacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT YYD2_k127_5998880_1 1162668.LFE_2206 1.304e-128 419.0 COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae 40117|Nitrospirae H Galactose-1-phosphate uridyl transferase, N-terminal domain galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf YYD2_k127_5998880_0 1379698.RBG1_1C00001G1309 3.929e-147 481.0 COG0297@1|root,COG0297@2|Bacteria,2NP1F@2323|unclassified Bacteria 2|Bacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 YYD2_k127_5998880_4 765420.OSCT_1275 3.464e-33 148.0 COG1807@1|root,COG1807@2|Bacteria,2G8IK@200795|Chloroflexi,375EI@32061|Chloroflexia 32061|Chloroflexia M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - - YYD2_k127_5998880_5 1379698.RBG1_1C00001G1198 3.633e-23 99.0 COG1145@1|root,COG1145@2|Bacteria 2|Bacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein fdxN - - ko:K03522 - - - - ko00000,ko04147 - - - Fer4,HTH_3,HTH_31 YYD2_k127_5998880_7 1379698.RBG1_1C00001G1104 8.819e-13 77.0 2B0A3@1|root,31SM2@2|Bacteria,2NRWJ@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 YYD2_k127_5998880_3 748280.NH8B_0056 2.034e-90 308.0 COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1MUBE@1224|Proteobacteria,2VPRG@28216|Betaproteobacteria,2KSUP@206351|Neisseriales 206351|Neisseriales E Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP YYD2_k127_5998880_8 1379858.N508_00599 0.000619 50.0 COG3087@1|root,COG3087@2|Bacteria,2GG1B@200930|Deferribacteres 200930|Deferribacteres D Sporulation related domain - - - - - - - - - - - - SPOR YYD2_k127_5998880_2 42256.RradSPS_0187 9.621e-120 408.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria,4CQV5@84995|Rubrobacteria 84995|Rubrobacteria EU Peptidase S9, prolyl oligopeptidase - - - - - - - - - - - - PD40,Peptidase_S9 YYD2_k127_6039946_0 1379698.RBG1_1C00001G0450 2.286e-101 336.0 COG1190@1|root,COG1190@2|Bacteria,2NNMH@2323|unclassified Bacteria 2|Bacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567,ko:K04568 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03012,ko03016 - - iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490 DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon YYD2_k127_6039946_5 1379281.AVAG01000009_gene607 4.236e-55 197.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2MBFU@213115|Desulfovibrionales 28221|Deltaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like YYD2_k127_6039946_11 1122994.AUFR01000004_gene712 1.996e-08 60.0 COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4DRFZ@85009|Propionibacteriales 201174|Actinobacteria L Helix-hairpin-helix motif comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB YYD2_k127_6039946_10 1202532.FF52_20687 5.899e-09 65.0 COG0746@1|root,COG0746@2|Bacteria,4NQQT@976|Bacteroidetes,1IIZW@117743|Flavobacteriia,2NUCX@237|Flavobacterium 976|Bacteroidetes H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 YYD2_k127_6039946_7 1379698.RBG1_1C00001G0548 5.58e-32 131.0 COG3117@1|root,COG3117@2|Bacteria,2NQ8Q@2323|unclassified Bacteria 2|Bacteria S Lipopolysaccharide-assembly, LptC-related lptC - - ko:K09774,ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC YYD2_k127_6039946_3 1379698.RBG1_1C00001G0547 1.491e-69 246.0 COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria 2|Bacteria M Lipid A biosynthesis htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans YYD2_k127_6039946_4 1380394.JADL01000002_gene1467 1.046e-57 207.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2U0HE@28211|Alphaproteobacteria,2JZEK@204441|Rhodospirillales 204441|Rhodospirillales E threonine efflux protein - - - - - - - - - - - - LysE YYD2_k127_6039946_1 1379698.RBG1_1C00001G0545 1.998e-98 331.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,2NNNB@2323|unclassified Bacteria 2|Bacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 2.5.1.55,5.3.1.13 ko:K01627,ko:K03281,ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530,R03254 RC00435,RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 2.A.49 - iAF987.Gmet_1278 CBS,SIS YYD2_k127_6039946_6 522772.Dacet_1305 8.422e-36 142.0 COG1778@1|root,COG1778@2|Bacteria,2GFN9@200930|Deferribacteres 200930|Deferribacteres S haloacid dehalogenase-like hydrolase - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 YYD2_k127_6039946_2 237368.SCABRO_03353 4.297e-86 293.0 COG2877@1|root,COG2877@2|Bacteria,2IXME@203682|Planctomycetes 203682|Planctomycetes M 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 YYD2_k127_6039946_12 1120978.KB894080_gene1353 0.0003596 49.0 29XWE@1|root,30JNT@2|Bacteria,1UW1M@1239|Firmicutes,4IC1J@91061|Bacilli,27GXQ@186828|Carnobacteriaceae 91061|Bacilli S Domain of unknown function (DUF4430) - - - - - - - - - - - - DUF4430 YYD2_k127_6039946_9 42256.RradSPS_0047 2.23e-14 83.0 2DFV5@1|root,2ZT9W@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_6134094_2 1173264.KI913949_gene37 1.545e-70 243.0 COG1791@1|root,COG1791@2|Bacteria,1G274@1117|Cyanobacteria 1117|Cyanobacteria S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway mtnD - 1.13.11.53,1.13.11.54 ko:K08967 ko00270,ko01100,map00270,map01100 M00034 R07363,R07364 RC01866,RC02018,RC02118 ko00000,ko00001,ko00002,ko01000 - - - ARD YYD2_k127_6134094_3 269084.syc2102_c 1.024e-67 238.0 COG4229@1|root,COG4229@2|Bacteria,1G59P@1117|Cyanobacteria,1H3Y4@1129|Synechococcus 1117|Cyanobacteria F Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) mtnC - 3.1.3.77 ko:K09880 ko00270,ko01100,map00270,map01100 M00034 R07395 RC02779 ko00000,ko00001,ko00002,ko01000 - - - HAD_2,Hydrolase YYD2_k127_6134094_1 1254432.SCE1572_31200 4.076e-104 351.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42N1P@68525|delta/epsilon subdivisions,2WM2V@28221|Deltaproteobacteria,2YU4D@29|Myxococcales 28221|Deltaproteobacteria E Aminotransferase - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_6134094_4 595537.Varpa_0937 5.179e-25 122.0 2FC4C@1|root,34489@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_6134094_0 404589.Anae109_1549 6.509e-131 447.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales 28221|Deltaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10,TPR_12 YYD2_k127_6143122_2 1379698.RBG1_1C00001G0414 1.419e-107 360.0 COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria 2|Bacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iLJ478.TM1817 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 YYD2_k127_6143122_7 1379698.RBG1_1C00001G0301 3.692e-40 173.0 COG2706@1|root,COG2706@2|Bacteria,2NR81@2323|unclassified Bacteria 2|Bacteria G Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - - - - - - - - - - Big_5,VCBS YYD2_k127_6143122_9 7955.ENSDARP00000124920 8.872e-06 60.0 2CMRF@1|root,2QRK8@2759|Eukaryota,38BZ6@33154|Opisthokonta,3BC6D@33208|Metazoa,3CRA6@33213|Bilateria,4834K@7711|Chordata,48Z6Z@7742|Vertebrata,49RWU@7898|Actinopterygii 33208|Metazoa W Thrombospondin 2a THBS2 GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0007275,GO:0008150,GO:0008201,GO:0009790,GO:0009888,GO:0009987,GO:0012505,GO:0016525,GO:0016528,GO:0016529,GO:0022603,GO:0030141,GO:0030154,GO:0030855,GO:0031012,GO:0031091,GO:0031410,GO:0031982,GO:0032501,GO:0032502,GO:0035989,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044087,GO:0044089,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045765,GO:0048518,GO:0048519,GO:0048522,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050803,GO:0050807,GO:0051093,GO:0051094,GO:0051128,GO:0051130,GO:0051239,GO:0051240,GO:0051241,GO:0051960,GO:0051962,GO:0051963,GO:0051965,GO:0060231,GO:0060429,GO:0061053,GO:0061448,GO:0062023,GO:0065007,GO:0065008,GO:0097367,GO:0097708,GO:0099503,GO:1901342,GO:1901343,GO:1901681,GO:2000026,GO:2000181 - ko:K04659,ko:K16857 ko04015,ko04115,ko04145,ko04151,ko04350,ko04510,ko04512,ko05144,ko05165,ko05205,ko05206,ko05219,map04015,map04115,map04145,map04151,map04350,map04510,map04512,map05144,map05165,map05205,map05206,map05219 - - - ko00000,ko00001,ko00536,ko04131,ko04147,ko04516 - - - EGF_3,EGF_CA,TSP_1,TSP_3,TSP_C,VWC YYD2_k127_6143122_3 1444711.CCJF01000005_gene546 3.891e-104 377.0 COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_5,Calx-beta,SBBP YYD2_k127_6143122_6 690850.Desaf_3498 8.831e-72 266.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - Beta_helix,Big_2,CarboxypepD_reg,He_PIG,LysM,PSII_BNR,SLH,TIG,fn3 YYD2_k127_6143122_5 1287276.X752_11730 8.35e-88 297.0 COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria 28211|Alphaproteobacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU,PEMT YYD2_k127_6143122_0 1379698.RBG1_1C00001G0159 3.195e-182 582.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD2_k127_6143122_1 1379698.RBG1_1C00001G0158 2.216e-175 574.0 COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,2NPIU@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg YYD2_k127_6143122_4 1379698.RBG1_1C00001G0157 2.145e-91 318.0 COG0642@1|root,COG2205@2|Bacteria 1379698.RBG1_1C00001G0157|- T PhoQ Sensor - - - - - - - - - - - - - YYD2_k127_6146393_0 679926.Mpet_0862 8.293e-06 58.0 COG1470@1|root,arCOG02087@2157|Archaea,2XW1B@28890|Euryarchaeota,2NBNC@224756|Methanomicrobia 28890|Euryarchaeota S PFAM NPCBM-associated, NEW3 domain of alpha-galactosidase - - - - - - - - - - - - CarboxypepD_reg,NPCBM_assoc YYD2_k127_6146393_1 314607.KB13_1086 2.718e-05 55.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1KQED@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD2_k127_61587_5 536232.CLM_2982 3.179e-29 121.0 COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,36E70@31979|Clostridiaceae 186801|Clostridia C flavodoxin nitric oxide synthase fprA1 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0017144,GO:0022900,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050664,GO:0055114,GO:0072592,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B YYD2_k127_61587_3 880073.Calab_2227 6.037e-44 168.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - 1.11.1.15,2.7.13.3 ko:K03564,ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - AhpC-TSA YYD2_k127_61587_6 1121445.ATUZ01000014_gene1484 3.529e-26 109.0 2B2V5@1|root,31VFQ@2|Bacteria,1QCMA@1224|Proteobacteria,436BA@68525|delta/epsilon subdivisions,2X0WD@28221|Deltaproteobacteria,2MDKE@213115|Desulfovibrionales 28221|Deltaproteobacteria S Pathogenicity locus - - - - - - - - - - - - Cdd1 YYD2_k127_61587_4 1380394.JADL01000003_gene5071 8.982e-38 152.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_25 YYD2_k127_61587_0 1304874.JAFY01000002_gene661 2.731e-178 566.0 COG0477@1|root,COG2814@2|Bacteria,3TACG@508458|Synergistetes 508458|Synergistetes EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 YYD2_k127_61587_2 234267.Acid_0827 1.504e-68 242.0 COG1108@1|root,COG1108@2|Bacteria,3Y93X@57723|Acidobacteria 57723|Acidobacteria P ABC 3 transport family - - - ko:K02075 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ABC-3 YYD2_k127_61587_1 1379698.RBG1_1C00001G0108 4.194e-76 265.0 COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria 2|Bacteria P Belongs to the bacterial solute-binding protein 9 family znuA - - ko:K02077,ko:K09815,ko:K09818 ko02010,map02010 M00242,M00243,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ZnuA YYD2_k127_61587_7 1313265.JNIE01000003_gene1301 1.629e-20 105.0 COG3746@1|root,COG3746@2|Bacteria,2G4NR@200783|Aquificae 200783|Aquificae P phosphate-selective porin O and P - - - - - - - - - - - - - YYD2_k127_6181653_11 96561.Dole_0811 2.444e-19 94.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria,2MJ98@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 YYD2_k127_6181653_6 96561.Dole_0810 2.82e-83 289.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42P7V@68525|delta/epsilon subdivisions,2WJQA@28221|Deltaproteobacteria,2MJ2Q@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein ybhS - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 YYD2_k127_6181653_5 290318.Cvib_0861 3.26e-88 297.0 COG1131@1|root,COG1131@2|Bacteria,1FDTT@1090|Chlorobi 1090|Chlorobi V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_6181653_7 338969.Rfer_0860 2.813e-75 265.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,4AJWS@80864|Comamonadaceae 28216|Betaproteobacteria V pfam abc - - - ko:K01990,ko:K13926 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_tran YYD2_k127_6181653_9 96561.Dole_0807 6.43e-51 191.0 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43BPM@68525|delta/epsilon subdivisions,2X70W@28221|Deltaproteobacteria 28221|Deltaproteobacteria V PFAM secretion protein HlyD family protein ybhG - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 YYD2_k127_6181653_14 1114964.L485_18340 2.131e-11 76.0 COG1538@1|root,COG1538@2|Bacteria,1R8ES@1224|Proteobacteria,2TRDW@28211|Alphaproteobacteria,2K3AV@204457|Sphingomonadales 204457|Sphingomonadales MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP YYD2_k127_6181653_10 96561.Dole_0805 4.621e-26 115.0 COG1309@1|root,COG1309@2|Bacteria,1RCDH@1224|Proteobacteria,42VJ5@68525|delta/epsilon subdivisions,2WRC7@28221|Deltaproteobacteria,2MKUA@213118|Desulfobacterales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_3,TetR_N YYD2_k127_6181653_17 1174528.JH992898_gene4175 5.475e-06 57.0 COG1716@1|root,COG1716@2|Bacteria,1G7WQ@1117|Cyanobacteria 1117|Cyanobacteria T ATPase activity - - - - - - - - - - - - - YYD2_k127_6181653_15 439235.Dalk_4320 4.355e-10 70.0 2DS9E@1|root,32VU1@2|Bacteria,1P3D6@1224|Proteobacteria,431R2@68525|delta/epsilon subdivisions,2WW7F@28221|Deltaproteobacteria,2MNTP@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_6181653_4 1380394.JADL01000004_gene6049 2.067e-103 352.0 COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,2TQZZ@28211|Alphaproteobacteria,2JPG0@204441|Rhodospirillales 204441|Rhodospirillales K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - - - - - - - - - - Aminotran_1_2,GntR YYD2_k127_6181653_2 673860.AciM339_1072 2.409e-117 391.0 COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota,3F2Z7@33867|unclassified Euryarchaeota 28890|Euryarchaeota K PFAM Aminotransferase class I and II - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 YYD2_k127_6181653_18 1148.1653840 8.255e-05 53.0 COG0288@1|root,COG0288@2|Bacteria,1G76H@1117|Cyanobacteria,1H6KK@1142|Synechocystis 1117|Cyanobacteria P reversible hydration of carbon dioxide - - - - - - - - - - - - - YYD2_k127_6181653_1 247490.KSU1_B0055 8.523e-198 627.0 COG3303@1|root,COG3303@2|Bacteria,2IYGG@203682|Planctomycetes 203682|Planctomycetes C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 YYD2_k127_6181653_8 338963.Pcar_2867 1.181e-51 187.0 COG3005@1|root,COG3005@2|Bacteria,1N0I4@1224|Proteobacteria,42R1B@68525|delta/epsilon subdivisions,2WQMW@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NapC/NirT cytochrome c family, N-terminal region nrfH - - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT YYD2_k127_6181653_13 1333856.L686_10185 2.051e-13 83.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1Z2CJ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria D Chain length determinant protein - - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - AAA_31,CBP_BcsQ,CbiA,GNVR,Wzz YYD2_k127_6181653_0 383372.Rcas_0489 2.269e-208 667.0 COG0367@1|root,COG0367@2|Bacteria,2G7R3@200795|Chloroflexi,376WK@32061|Chloroflexia 32061|Chloroflexia E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 YYD2_k127_6181653_3 880073.Calab_1595 4.543e-114 387.0 COG0318@1|root,COG0318@2|Bacteria,2NPH9@2323|unclassified Bacteria 2|Bacteria IQ COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C YYD2_k127_6181653_12 344747.PM8797T_19627 2.14e-18 87.0 COG0236@1|root,COG0236@2|Bacteria,2J1MP@203682|Planctomycetes 203682|Planctomycetes IQ acyl carrier protein - - - - - - - - - - - - PP-binding YYD2_k127_6185457_18 1379698.RBG1_1C00001G0150 1.992e-14 75.0 COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N YYD2_k127_6185457_11 264732.Moth_2379 2.783e-69 244.0 COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,42FTI@68295|Thermoanaerobacterales 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt YYD2_k127_6185457_0 1379698.RBG1_1C00001G0153 3.564e-239 745.0 COG0055@1|root,COG0055@2|Bacteria,2NNRB@2323|unclassified Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N YYD2_k127_6185457_14 1379698.RBG1_1C00001G0155 5.818e-32 129.0 COG0355@1|root,COG0355@2|Bacteria,2NPSQ@2323|unclassified Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01195,iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190 ATP-synt_DE,ATP-synt_DE_N YYD2_k127_6185457_16 1379698.RBG1_1C00001G1830 2.873e-24 109.0 COG1399@1|root,COG1399@2|Bacteria,2NPVD@2323|unclassified Bacteria 2|Bacteria S Uncharacterized ACR, COG1399 yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K07040 - - - - ko00000 - - - DUF177 YYD2_k127_6185457_17 1379698.RBG1_1C00001G1829 1.742e-23 100.0 COG0333@1|root,COG0333@2|Bacteria,2NQ1M@2323|unclassified Bacteria 2|Bacteria J Ribosomal L32p protein family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p YYD2_k127_6185457_7 1379698.RBG1_1C00001G1828 6.602e-83 288.0 COG0416@1|root,COG0416@2|Bacteria,2NP1H@2323|unclassified Bacteria 2|Bacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis YYD2_k127_6185457_4 697303.Thewi_1430 5.5e-110 364.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42ER1@68295|Thermoanaerobacterales 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C YYD2_k127_6185457_9 1379698.RBG1_1C00001G1827 5.531e-80 277.0 COG0331@1|root,COG0331@2|Bacteria,2NP3V@2323|unclassified Bacteria 2|Bacteria I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645,ko:K15327,ko:K15329,ko:K15355,ko:K15469 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Acyl_transf_1 YYD2_k127_6185457_6 1120985.AUMI01000019_gene2296 3.656e-85 288.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4H2JC@909932|Negativicutes 909932|Negativicutes IQ reductase fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 YYD2_k127_6185457_15 1379698.RBG1_1C00001G1825 2.416e-26 109.0 COG0236@1|root,COG0236@2|Bacteria,2NPVJ@2323|unclassified Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding YYD2_k127_6185457_2 1379698.RBG1_1C00001G1824 2.407e-179 569.0 COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179,2.3.1.41 ko:K00647,ko:K09458,ko:K14660 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iSB619.SA_RS04785 Ketoacyl-synt_C,ketoacyl-synt YYD2_k127_6185457_12 1379698.RBG1_1C00001G1823 2.467e-68 239.0 COG0571@1|root,COG0571@2|Bacteria,2NPCJ@2323|unclassified Bacteria 2|Bacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm YYD2_k127_6185457_8 1379698.RBG1_1C00001G1822 1.308e-80 277.0 COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria 2|Bacteria C Electron transfer flavoprotein etfB GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 - ko:K03521 - - - - ko00000 - - - ETF YYD2_k127_6185457_13 118166.JH976537_gene3154 2.829e-34 134.0 COG0662@1|root,COG0662@2|Bacteria,1G5PK@1117|Cyanobacteria,1HC1C@1150|Oscillatoriales 1117|Cyanobacteria G PFAM Cupin - - - - - - - - - - - - Cupin_2 YYD2_k127_6185457_19 1234664.AMRO01000048_gene861 6.145e-05 56.0 COG2120@1|root,COG2120@2|Bacteria,1UYPV@1239|Firmicutes,4HCT3@91061|Bacilli 91061|Bacilli M NPCBM-associated, NEW3 domain of alpha-galactosidase - - - - - - - - - - - - NPCBM_assoc,PIG-L YYD2_k127_6185457_3 234267.Acid_3848 3.101e-144 477.0 COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria 57723|Acidobacteria V ABC transporter transmembrane - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran YYD2_k127_6185457_1 1191523.MROS_1555 8.78e-192 616.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter MdlB - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran YYD2_k127_6185457_10 671143.DAMO_0010 4.423e-70 247.0 COG0483@1|root,COG0483@2|Bacteria,2NP94@2323|unclassified Bacteria 2|Bacteria G Inositol monophosphatase suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P YYD2_k127_6185457_5 1379698.RBG1_1C00001G0687 5.642e-107 359.0 COG1109@1|root,COG1109@2|Bacteria,2NNM3@2323|unclassified Bacteria 2|Bacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III glmM - 5.4.2.10,5.4.2.2,5.4.2.8 ko:K01840,ko:K03431,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R02060,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV YYD2_k127_618732_2 373903.Hore_15740 1.73e-53 194.0 COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,3WANC@53433|Halanaerobiales 186801|Clostridia S PFAM metal-dependent phosphohydrolase HD sub domain - - - ko:K06951 - - - - ko00000 - - - HD YYD2_k127_618732_0 1379698.RBG1_1C00001G1242 2.947e-96 330.0 COG2270@1|root,COG2270@2|Bacteria,2NP3G@2323|unclassified Bacteria 2|Bacteria S Vacuole effluxer Atg22 like yxiO - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22,MFS_1 YYD2_k127_618732_1 1379698.RBG1_1C00001G1241 3.26e-88 297.0 COG0613@1|root,COG0613@2|Bacteria,2NPWD@2323|unclassified Bacteria 2|Bacteria S PHP domain protein - - - - - - - - - - - - PHP YYD2_k127_6226918_0 234267.Acid_5940 3.076e-210 685.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase YYD2_k127_6226918_1 1379698.RBG1_1C00001G1233 6.753e-164 535.0 COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 YYD2_k127_6226918_23 1235798.C817_01991 0.0003873 51.0 COG0681@1|root,COG0681@2|Bacteria,1V2SF@1239|Firmicutes,24AWM@186801|Clostridia,27VIG@189330|Dorea 186801|Clostridia U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 YYD2_k127_6226918_17 1027292.HMPREF9372_3586 9.934e-30 127.0 COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,4HE7X@91061|Bacilli,26ETR@186818|Planococcaceae 91061|Bacilli S Pyrophosphatase PpaX ppaX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.1 ko:K06019 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - HAD_2 YYD2_k127_6226918_3 941824.TCEL_02364 1.293e-131 431.0 COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,36E9B@31979|Clostridiaceae 186801|Clostridia E aminopeptidase - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 YYD2_k127_6226918_21 504487.JCM19302_2841 2.909e-05 57.0 COG3291@1|root,COG4935@1|root,COG3291@2|Bacteria,COG4935@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia 976|Bacteroidetes DZ adhesin AidA-related - - - - - - - - - - - - CHU_C,PKD,SprB YYD2_k127_6226918_6 1379698.RBG1_1C00001G1263 4.117e-104 368.0 COG1404@1|root,COG1404@2|Bacteria,2NNSK@2323|unclassified Bacteria 2|Bacteria O Subtilase family aprN - - - - - - - - - - - Peptidase_S8 YYD2_k127_6226918_22 425104.Ssed_1205 3.168e-05 53.0 COG4970@1|root,COG4970@2|Bacteria,1Q92Y@1224|Proteobacteria,1SX5X@1236|Gammaproteobacteria,2QBV8@267890|Shewanellaceae 1236|Gammaproteobacteria NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl YYD2_k127_6226918_2 1379698.RBG1_1C00001G1258 7.753e-149 482.0 COG4972@1|root,COG4972@2|Bacteria,2NPF6@2323|unclassified Bacteria 2|Bacteria NU Type IV pilus assembly protein PilM; pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 YYD2_k127_6226918_14 1379698.RBG1_1C00001G1257 1.26e-35 145.0 COG3166@1|root,COG3166@2|Bacteria 2|Bacteria NU PFAM Fimbrial assembly family protein pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN YYD2_k127_6226918_12 1379698.RBG1_1C00001G1256 7.929e-47 175.0 COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria 2|Bacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO YYD2_k127_6226918_5 1379698.RBG1_1C00001G1254 8.414e-112 375.0 COG4796@1|root,COG4796@2|Bacteria,2NPEQ@2323|unclassified Bacteria 2|Bacteria U Secretin and TonB N terminus short domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N YYD2_k127_6226918_19 1121104.AQXH01000001_gene1022 5.902e-12 79.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding sorCs3 - - - - - - - - - - - BNR,Cu_amine_oxidN1,PSII_BNR,Sortilin-Vps10 YYD2_k127_6226918_4 1379698.RBG1_1C00001G1253 4.21e-126 424.0 COG1022@1|root,COG1022@2|Bacteria,2NNTM@2323|unclassified Bacteria 2|Bacteria I COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding YYD2_k127_6226918_7 1121428.DESHY_40040___1 5.889e-104 347.0 COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,260GP@186807|Peptococcaceae 186801|Clostridia J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B YYD2_k127_6226918_20 1385510.N781_07270 1.027e-07 61.0 COG3091@1|root,COG3091@2|Bacteria,1V6NU@1239|Firmicutes,4HIHY@91061|Bacilli,2YADR@289201|Pontibacillus 91061|Bacilli S Belongs to the SprT family ydcK - - ko:K03095 - - - - ko00000 - - - SprT-like,Zn_ribbon_SprT YYD2_k127_6226918_13 1379858.N508_02091 1.179e-36 143.0 COG0102@1|root,COG0102@2|Bacteria,2GFHA@200930|Deferribacteres 200930|Deferribacteres J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 YYD2_k127_6226918_15 1379698.RBG1_1C00001G1016 2.697e-35 138.0 COG0103@1|root,COG0103@2|Bacteria,2NPN8@2323|unclassified Bacteria 2|Bacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 YYD2_k127_6226918_9 1379698.RBG1_1C00001G1017 1.975e-85 290.0 COG0052@1|root,COG0052@2|Bacteria,2NP4M@2323|unclassified Bacteria 2|Bacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 YYD2_k127_6226918_10 864563.HMPREF9166_0263 6.965e-75 261.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4H35I@909932|Negativicutes 909932|Negativicutes J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS YYD2_k127_6226918_8 483219.LILAB_34540 5.721e-88 296.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase YYD2_k127_6226918_11 315750.BPUM_1551 1.401e-56 203.0 COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,4HFSH@91061|Bacilli,1ZAZF@1386|Bacillus 91061|Bacilli J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF YYD2_k127_6226918_18 1121403.AUCV01000026_gene2353 3.4e-17 82.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,43CQG@68525|delta/epsilon subdivisions 1224|Proteobacteria S Domain in cystathionine beta-synthase and other proteins. MA20_31615 - - - - - - - - - - - CBS YYD2_k127_6256574_0 1210884.HG799463_gene9843 5.979e-296 919.0 COG3256@1|root,COG3256@2|Bacteria,2J2IF@203682|Planctomycetes 203682|Planctomycetes P Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 YYD2_k127_6256574_1 552811.Dehly_1481 9.792e-43 164.0 COG3945@1|root,COG3945@2|Bacteria 2|Bacteria P hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin YYD2_k127_6256574_3 1382356.JQMP01000001_gene797 2.095e-22 101.0 COG1959@1|root,COG1959@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 YYD2_k127_6256574_2 479432.Sros_1372 6.542e-25 116.0 COG0392@1|root,COG0392@2|Bacteria,2IC25@201174|Actinobacteria,4EHA8@85012|Streptosporangiales 201174|Actinobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027,ko:K20468 - - - - ko00000,ko02000 4.D.2,4.D.2.4.1 - - LPG_synthase_TM YYD2_k127_6256574_4 1123503.KB908056_gene1309 1.125e-19 102.0 2941A@1|root,2ZRG3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_6259735_11 1278073.MYSTI_03146 3.34e-15 81.0 COG1959@1|root,COG1959@2|Bacteria,1Q19C@1224|Proteobacteria,4375I@68525|delta/epsilon subdivisions,2WRDB@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 YYD2_k127_6259735_0 1379698.RBG1_1C00001G1656 0.0 1217.0 COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW YYD2_k127_6259735_9 1237149.C900_00817 5.04e-34 136.0 COG2318@1|root,COG2318@2|Bacteria,4NSE5@976|Bacteroidetes,47S2U@768503|Cytophagia 976|Bacteroidetes S DinB family - - - - - - - - - - - - DinB YYD2_k127_6259735_6 1515746.HR45_18580 1.83e-61 222.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,2QA3K@267890|Shewanellaceae 1236|Gammaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022613,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0036094,GO:0042254,GO:0042274,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - iAF1260.b4161,iBWG_1329.BWG_3876,iECDH10B_1368.ECDH10B_4356,iECDH1ME8569_1439.ECDH1ME8569_4021,iEKO11_1354.EKO11_4148,iEcDH1_1363.EcDH1_3829,iEcolC_1368.EcolC_3849,iJO1366.b4161,iUMNK88_1353.UMNK88_5099,iY75_1357.Y75_RS21675 RsgA_GTPase YYD2_k127_6259735_10 1191523.MROS_2558 1.782e-24 114.0 COG1463@1|root,COG1463@2|Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, periplasmic component ttg2C - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD YYD2_k127_6259735_1 880073.Calab_2422 3.428e-191 619.0 COG1449@1|root,COG1449@2|Bacteria,2NQNB@2323|unclassified Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 57 family amyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 ko:K22451 ko00500,map00500 - R05196 RC00049 ko00000,ko00001,ko01000 - GH57 - DUF1925,DUF1926,Glyco_hydro_57 YYD2_k127_6259735_4 518766.Rmar_2323 2.992e-80 275.0 COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,1FIMG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form - - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 YYD2_k127_6259735_5 1379698.RBG1_1C00001G0226 4.441e-65 251.0 COG1729@1|root,COG1729@2|Bacteria,2NPUR@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 YYD2_k127_6259735_8 643648.Slip_0840 1.233e-50 189.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,42K0H@68298|Syntrophomonadaceae 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 YYD2_k127_6259735_2 868864.Dester_1492 1.872e-88 301.0 COG0167@1|root,COG0167@2|Bacteria,2G3JU@200783|Aquificae 200783|Aquificae F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh YYD2_k127_6259735_3 1379698.RBG1_1C00001G0223 2.512e-81 284.0 COG0284@1|root,COG0284@2|Bacteria,2NP92@2323|unclassified Bacteria 2|Bacteria F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 ko:K01591,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS17585 OMPdecase YYD2_k127_6259735_7 661478.OP10G_0354 2.559e-59 212.0 COG4312@1|root,COG4312@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF899) - - - - - - - - - - - - DUF899 YYD2_k127_6288428_1 644966.Tmar_1747 2.131e-18 94.0 COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia 1239|Firmicutes C FAD linked oxidases, C-terminal domain - - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 YYD2_k127_6288428_0 1137799.GZ78_14000 9.124e-74 257.0 COG0500@1|root,COG2226@2|Bacteria,1R6ZI@1224|Proteobacteria,1SYW2@1236|Gammaproteobacteria,1XK75@135619|Oceanospirillales 135619|Oceanospirillales Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_11 YYD2_k127_6288428_2 1379698.RBG1_1C00001G0198 1.544e-17 96.0 COG2885@1|root,COG5276@1|root,COG2885@2|Bacteria,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - - - - - - - - - - - Phenol_MetA_deg YYD2_k127_6288428_3 1379281.AVAG01000087_gene707 6.096e-15 74.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2M84Y@213115|Desulfovibrionales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 YYD2_k127_6292529_7 1444711.CCJF01000005_gene1677 6.13e-20 89.0 COG0365@1|root,COG0365@2|Bacteria,2JFRM@204428|Chlamydiae 204428|Chlamydiae I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C YYD2_k127_6292529_9 1206732.BAGD01000066_gene2495 1.563e-12 74.0 COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria,4FU8U@85025|Nocardiaceae 201174|Actinobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase YYD2_k127_6292529_8 179408.Osc7112_1799 2.782e-13 72.0 COG1308@1|root,COG1308@2|Bacteria,1G83N@1117|Cyanobacteria,1HC9J@1150|Oscillatoriales 1117|Cyanobacteria K Domain of unknown function (DUF4342) - - - - - - - - - - - - DUF4342 YYD2_k127_6292529_6 1120968.AUBX01000009_gene84 2.449e-32 132.0 COG0454@1|root,COG0456@2|Bacteria,4NHRI@976|Bacteroidetes,47RPY@768503|Cytophagia 976|Bacteroidetes K PFAM Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 YYD2_k127_6292529_0 246194.CHY_1350 4.572e-124 408.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales 186801|Clostridia C PFAM Acyl-CoA dehydrogenase bcd2 - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin YYD2_k127_6292529_3 1379698.RBG1_1C00001G1006 1.322e-56 207.0 COG0682@1|root,COG0682@2|Bacteria,2NPK2@2323|unclassified Bacteria 2|Bacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT YYD2_k127_6292529_5 1379698.RBG1_1C00001G0055 2.553e-43 170.0 COG0671@1|root,COG0671@2|Bacteria,2NRVZ@2323|unclassified Bacteria 2|Bacteria I PAP2 superfamily - - - - - - - - - - - - PAP2_3 YYD2_k127_6292529_1 543734.LCABL_24370 8.131e-70 245.0 COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,4HAH8@91061|Bacilli,3F4AI@33958|Lactobacillaceae 91061|Bacilli H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase YYD2_k127_6292529_2 648996.Theam_0757 1.123e-69 245.0 COG0171@1|root,COG0171@2|Bacteria,2G425@200783|Aquificae 200783|Aquificae H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase YYD2_k127_6292529_4 1379698.RBG1_1C00001G0504 5.465e-46 172.0 COG0629@1|root,COG0629@2|Bacteria,2NPP5@2323|unclassified Bacteria 2|Bacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB YYD2_k127_6300691_6 102125.Xen7305DRAFT_00051550 0.0003575 48.0 COG1366@1|root,COG1366@2|Bacteria,1GJCJ@1117|Cyanobacteria,3VN26@52604|Pleurocapsales 1117|Cyanobacteria T STAS domain - - - - - - - - - - - - STAS YYD2_k127_6300691_1 740709.A10D4_00975 3.076e-47 186.0 COG1520@1|root,COG3209@1|root,COG3210@1|root,COG1520@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria 2|Bacteria U domain, Protein yeeJ - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - CHU_C,Calx-beta,Flg_new,HYR,Laminin_G_3,PQQ_2 YYD2_k127_6300691_0 635013.TherJR_0008 1.796e-271 852.0 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,260WQ@186807|Peptococcaceae 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim YYD2_k127_6300691_5 446465.Bfae_00040 1.824e-07 58.0 COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4FBS4@85020|Dermabacteraceae 201174|Actinobacteria S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 YYD2_k127_6300691_3 1202532.FF52_21253 4.01e-20 99.0 COG3595@1|root,COG3595@2|Bacteria,4NSAQ@976|Bacteroidetes,1I1B3@117743|Flavobacteriia,2NTX1@237|Flavobacterium 976|Bacteroidetes S Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 YYD2_k127_6300691_2 1379698.RBG1_1C00001G1312 6.762e-28 123.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity plnP - - ko:K07052 - - - - ko00000 - - - Abi YYD2_k127_6302251_3 945713.IALB_2208 5.924e-94 321.0 COG0771@1|root,COG0771@2|Bacteria 2|Bacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M YYD2_k127_6302251_0 1379698.RBG1_1C00001G0393 6.293e-147 473.0 COG0472@1|root,COG0472@2|Bacteria,2NNQW@2323|unclassified Bacteria 2|Bacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 YYD2_k127_6302251_4 1379698.RBG1_1C00001G0392 6.457e-81 287.0 COG0770@1|root,COG0770@2|Bacteria,2NP4Q@2323|unclassified Bacteria 2|Bacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M YYD2_k127_6302251_1 644966.Tmar_0865 9.435e-122 408.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3WCXE@538999|Clostridiales incertae sedis 186801|Clostridia M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M YYD2_k127_6302251_2 517418.Ctha_0827 7.244e-98 345.0 COG0768@1|root,COG2815@1|root,COG0768@2|Bacteria,COG2815@2|Bacteria,1FDDH@1090|Chlorobi 1090|Chlorobi M PFAM penicillin-binding protein transpeptidase - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase YYD2_k127_6302251_5 1121423.JONT01000001_gene2052 4.398e-75 263.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,260DT@186807|Peptococcaceae 186801|Clostridia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 YYD2_k127_6302251_6 635013.TherJR_2169 8.493e-33 133.0 COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,261XI@186807|Peptococcaceae 186801|Clostridia K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ YYD2_k127_6302251_7 742726.HMPREF9448_00739 7.247e-27 125.0 COG4870@1|root,COG4870@2|Bacteria,4PNXD@976|Bacteroidetes,2G101@200643|Bacteroidia 976|Bacteroidetes O Propeptide_C25 - - - - - - - - - - - - Peptidase_C25,Propeptide_C25 YYD2_k127_6380085_13 379066.GAU_1023 7.067e-31 132.0 COG3121@1|root,COG3121@2|Bacteria 2|Bacteria NU pilus organization - - - - - - - - - - - - ASH,AhpC-TSA,Calx-beta,HemolysinCabind,LVIVD,PPC,PapD_N,Peptidase_S8 YYD2_k127_6380085_5 865937.Gilli_0418 8.799e-91 330.0 COG3188@1|root,COG3188@2|Bacteria,4NFPY@976|Bacteroidetes,1HXS8@117743|Flavobacteriia,2P5CG@244698|Gillisia 976|Bacteroidetes NU usher protein - - - - - - - - - - - - - YYD2_k127_6380085_10 1232410.KI421413_gene750 1.667e-54 217.0 COG2885@1|root,COG3210@1|root,COG5184@1|root,COG5276@1|root,COG2885@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria 28221|Deltaproteobacteria DZ Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 YYD2_k127_6380085_15 1379698.RBG1_1C00001G1377 3.016e-14 87.0 COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase YYD2_k127_6380085_11 1397527.Q670_09385 1.981e-52 200.0 COG3391@1|root,COG5184@1|root,COG5276@1|root,COG3391@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria,1QUHA@1224|Proteobacteria,1T1YV@1236|Gammaproteobacteria,1XS25@135619|Oceanospirillales 135619|Oceanospirillales DZ Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 YYD2_k127_6380085_1 1304284.L21TH_0121 6.963e-178 578.0 COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia,36DG9@31979|Clostridiaceae 186801|Clostridia E oligoendopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N YYD2_k127_6380085_14 1437425.CSEC_1883 3.132e-28 119.0 COG0824@1|root,COG0824@2|Bacteria,2JG70@204428|Chlamydiae 204428|Chlamydiae S Acyl-ACP thioesterase - - 3.1.2.28 ko:K12073 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07262 RC00004,RC00174 ko00000,ko00001,ko00002,ko01000 - - - 4HBT_2 YYD2_k127_6380085_4 42256.RradSPS_2309 2.203e-102 350.0 COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4CPCU@84995|Rubrobacteria 84995|Rubrobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C YYD2_k127_6380085_12 42256.RradSPS_2310 4.853e-52 201.0 COG4948@1|root,COG4948@2|Bacteria 2|Bacteria M carboxylic acid catabolic process menC GO:0008150,GO:0040007 4.2.1.113,5.1.1.20,5.1.1.3 ko:K01776,ko:K02549,ko:K19802 ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110 M00116 R00260,R04031,R10938 RC00302,RC01053,RC03309 ko00000,ko00001,ko00002,ko01000,ko01011 - - iNJ661.Rv0553,iSB619.SA_RS09080 MR_MLE_C YYD2_k127_6380085_6 518766.Rmar_0586 1.056e-82 284.0 COG1575@1|root,COG1575@2|Bacteria,4NGCJ@976|Bacteroidetes,1FIUJ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Belongs to the MenA family. Type 1 subfamily menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA YYD2_k127_6380085_3 331678.Cphamn1_2077 3.374e-151 480.0 COG0447@1|root,COG0447@2|Bacteria,1FDH0@1090|Chlorobi 1090|Chlorobi H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 YYD2_k127_6380085_9 266117.Rxyl_2894 2.696e-67 237.0 COG2267@1|root,COG2267@2|Bacteria,2GYP0@201174|Actinobacteria,4CQF4@84995|Rubrobacteria 84995|Rubrobacteria I Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_6 YYD2_k127_6380085_2 266117.Rxyl_2896 7.36e-156 510.0 COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4CPYA@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N YYD2_k127_6380085_7 309807.SRU_1350 3.935e-73 264.0 COG1169@1|root,COG1169@2|Bacteria,4NF6U@976|Bacteroidetes,1FIXW@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes the conversion of chorismate to isochorismate entC - 5.4.4.2 ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind YYD2_k127_6380085_8 331113.SNE_A14190 1.329e-71 249.0 COG0500@1|root,COG2226@2|Bacteria,2JG4F@204428|Chlamydiae 204428|Chlamydiae H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran YYD2_k127_6380085_0 648757.Rvan_1397 3.372e-190 614.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria 1224|Proteobacteria S oligopeptide transporter - - - - - - - - - - - - OPT YYD2_k127_6384360_0 861299.J421_1405 4.564e-19 90.0 2A4E9@1|root,2ZJRI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_6384881_6 485913.Krac_8724 6.143e-10 66.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB_2 YYD2_k127_6384881_1 1395587.P364_0129145 5.051e-67 237.0 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,4H9QA@91061|Bacilli,26RR9@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase YYD2_k127_6384881_3 1120973.AQXL01000088_gene3230 4.26e-28 116.0 COG2314@1|root,COG2314@2|Bacteria,1VESS@1239|Firmicutes,4HP3D@91061|Bacilli 91061|Bacilli S TM2 domain - - - - - - - - - - - - - YYD2_k127_6384881_4 573061.Clocel_4269 8.26e-18 92.0 COG1852@1|root,COG1852@2|Bacteria,1UZ1X@1239|Firmicutes,24A38@186801|Clostridia,36EPT@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF116 - - - - - - - - - - - - DUF116 YYD2_k127_6384881_5 1123256.KB907925_gene1078 2.426e-15 83.0 COG0127@1|root,COG0454@1|root,COG0127@2|Bacteria,COG0456@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1X4DK@135614|Xanthomonadales 135614|Xanthomonadales F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Ham1p_like YYD2_k127_6384881_0 1379698.RBG1_1C00001G0688 5.999e-275 857.0 COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria 2|Bacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iAF987.Gmet_1487 GATase_6,SIS YYD2_k127_6384881_2 1379698.RBG1_1C00001G0687 1.836e-41 159.0 COG1109@1|root,COG1109@2|Bacteria,2NNM3@2323|unclassified Bacteria 2|Bacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III glmM - 5.4.2.10,5.4.2.2,5.4.2.8 ko:K01840,ko:K03431,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R02060,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV YYD2_k127_671746_1 1379698.RBG1_1C00001G1724 2.099e-75 259.0 COG0845@1|root,COG0845@2|Bacteria,2NR7K@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mdtA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 YYD2_k127_671746_0 1379698.RBG1_1C00001G1725 1.743e-320 994.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran YYD2_k127_683230_1 518766.Rmar_2560 3.291e-80 277.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NEIE@976|Bacteroidetes,1FIS3@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,OMP_b-brl_3,Plug,TonB_dep_Rec YYD2_k127_683230_0 1122176.KB903587_gene4522 2.165e-153 514.0 COG0739@1|root,COG3291@1|root,COG0739@2|Bacteria,COG3291@2|Bacteria,4PKU5@976|Bacteroidetes,1J0XQ@117747|Sphingobacteriia 976|Bacteroidetes M heme binding - - - - - - - - - - - - - YYD2_k127_68999_10 1379698.RBG1_1C00001G1769 1.296e-25 111.0 COG0640@1|root,COG0640@2|Bacteria,2NQ1G@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 YYD2_k127_68999_5 913325.N799_06400 5.797e-108 364.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1X37F@135614|Xanthomonadales 135614|Xanthomonadales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF YYD2_k127_68999_0 1379698.RBG1_1C00001G1471 5.184e-265 824.0 COG4799@1|root,COG4799@2|Bacteria,2NNWQ@2323|unclassified Bacteria 2|Bacteria I carboxyl transferase pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans YYD2_k127_68999_7 1379698.RBG1_1C00001G1472 6.041e-72 254.0 COG0491@1|root,COG0491@2|Bacteria,2NPRD@2323|unclassified Bacteria 2|Bacteria S Metallo-beta-lactamase superfamily ytnP - - - - - - - - - - - Lactamase_B YYD2_k127_68999_4 1379698.RBG1_1C00001G1473 1.063e-135 441.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha YYD2_k127_68999_9 1191523.MROS_0387 9.142e-57 200.0 COG2185@1|root,COG2185@2|Bacteria 2|Bacteria I cobalamin binding - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding YYD2_k127_68999_1 1379698.RBG1_1C00001G1475 4.661e-235 739.0 COG1884@1|root,COG1884@2|Bacteria,2NNZ9@2323|unclassified Bacteria 2|Bacteria I Methylmalonyl-CoA mutase icmA - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase YYD2_k127_68999_12 143224.JQMD01000002_gene560 2.253e-11 76.0 2EVZZ@1|root,33PDF@2|Bacteria,4P17P@976|Bacteroidetes,1I798@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_68999_11 143224.JQMD01000002_gene560 1.939e-20 104.0 2EVZZ@1|root,33PDF@2|Bacteria,4P17P@976|Bacteroidetes,1I798@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD2_k127_68999_6 1379698.RBG1_1C00001G1476 8.13e-81 280.0 COG1703@1|root,COG1703@2|Bacteria,2NP56@2323|unclassified Bacteria 2|Bacteria E LAO AO transport system ATPase argK - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK YYD2_k127_68999_3 1379698.RBG1_1C00001G1477 3.785e-176 571.0 COG0608@1|root,COG0608@2|Bacteria,2NNRX@2323|unclassified Bacteria 2|Bacteria L single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 YYD2_k127_68999_13 1094715.CM001373_gene1338 1.543e-09 61.0 2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - YYD2_k127_68999_2 868864.Dester_1518 1.222e-178 572.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2G3I9@200783|Aquificae 200783|Aquificae F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH YYD2_k127_68999_8 1379698.RBG1_1C00001G1480 2.58e-57 208.0 COG1579@1|root,COG1579@2|Bacteria,2NPW0@2323|unclassified Bacteria 2|Bacteria S C4-type zinc ribbon domain CP_0228 - 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - zf-RING_7 YYD2_k127_700147_13 595460.RRSWK_00245 2.103e-19 91.0 COG1131@1|root,COG1131@2|Bacteria,2IZ31@203682|Planctomycetes 203682|Planctomycetes V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_700147_15 1379698.RBG1_1C00001G1104 5.164e-12 75.0 2B0A3@1|root,31SM2@2|Bacteria,2NRWJ@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 YYD2_k127_700147_18 243231.GSU2713 5.458e-06 52.0 2CG1Y@1|root,32WID@2|Bacteria,1N01A@1224|Proteobacteria,42UK0@68525|delta/epsilon subdivisions,2WQED@28221|Deltaproteobacteria,43SMQ@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573,PapD-like YYD2_k127_700147_16 1379698.RBG1_1C00001G1104 2.614e-09 65.0 2B0A3@1|root,31SM2@2|Bacteria,2NRWJ@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 YYD2_k127_700147_12 316067.Geob_1620 7.421e-20 99.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - ko:K16191,ko:K20276 ko02024,map02024 - - - ko00000,ko00001,ko02000 1.B.6.1.3 - - Big_3_2,Calx-beta,OmpA YYD2_k127_700147_10 945713.IALB_0760 5.542e-27 127.0 COG4219@1|root,COG4219@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 YYD2_k127_700147_8 1379698.RBG1_1C00001G1368 3.699e-64 237.0 COG4219@1|root,COG4219@2|Bacteria,2NS3V@2323|unclassified Bacteria 2|Bacteria KT Peptidase M56 - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 YYD2_k127_700147_1 1379698.RBG1_1C00001G1367 1.899e-116 387.0 COG0577@1|root,COG0577@2|Bacteria,2NNN0@2323|unclassified Bacteria 2|Bacteria V COGs COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_700147_5 1379698.RBG1_1C00001G1366 2.029e-94 323.0 COG0577@1|root,COG0577@2|Bacteria,2NQMU@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD2_k127_700147_2 639030.JHVA01000001_gene86 6.864e-106 348.0 COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_700147_3 1379698.RBG1_1C00001G1364 7.756e-101 344.0 COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family macA - - ko:K02005,ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP YYD2_k127_700147_9 215803.DB30_3564 3.175e-34 147.0 COG1538@1|root,COG1538@2|Bacteria,1Q54P@1224|Proteobacteria,42NQV@68525|delta/epsilon subdivisions,2X5KQ@28221|Deltaproteobacteria,2YYUS@29|Myxococcales 28221|Deltaproteobacteria M Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP YYD2_k127_700147_17 1195236.CTER_1063 1.261e-06 59.0 2EJ6V@1|root,33CY2@2|Bacteria,1VPDN@1239|Firmicutes,24FI9@186801|Clostridia 186801|Clostridia S Yip1 domain - - - - - - - - - - - - Yip1 YYD2_k127_700147_4 1218173.BALCAV_0209370 1.963e-100 336.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,4HA4N@91061|Bacilli,1ZBDJ@1386|Bacillus 91061|Bacilli C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 YYD2_k127_700147_7 1379698.RBG1_1C00001G1085 1.754e-68 236.0 COG2109@1|root,COG2109@2|Bacteria,2NPNR@2323|unclassified Bacteria 2|Bacteria H ATP:corrinoid adenosyltransferase BtuR/CobO/CobP - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR YYD2_k127_700147_11 316067.Geob_2631 7.699e-24 106.0 COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,43UWZ@69541|Desulfuromonadales 28221|Deltaproteobacteria K transcriptional regulator, Rrf2 family - - - - - - - - - - - - Rrf2 YYD2_k127_700147_6 671143.DAMO_1182 2.047e-72 248.0 COG0717@1|root,COG0717@2|Bacteria,2NQ5G@2323|unclassified Bacteria 2|Bacteria F Belongs to the dCTP deaminase family dcd GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase YYD2_k127_700147_0 665571.STHERM_c16630 3.557e-238 757.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2J5QV@203691|Spirochaetes 203691|Spirochaetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C YYD2_k127_700147_14 204669.Acid345_1867 1.06e-17 90.0 COG1136@1|root,COG1321@1|root,COG1136@2|Bacteria,COG1321@2|Bacteria,3Y3P4@57723|Acidobacteria,2JHU7@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD2_k127_700776_4 644282.Deba_3254 2.034e-32 131.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Biotin carboxylase pccA - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 YYD2_k127_700776_6 290397.Adeh_0258 1.256e-12 74.0 COG4770@1|root,COG4770@2|Bacteria,1RJYU@1224|Proteobacteria,42WT6@68525|delta/epsilon subdivisions,2WSN5@28221|Deltaproteobacteria,2Z2BY@29|Myxococcales 28221|Deltaproteobacteria I Biotin-requiring enzyme - - - - - - - - - - - - Biotin_lipoyl YYD2_k127_700776_5 379066.GAU_0150 2.496e-13 78.0 2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl YYD2_k127_700776_7 379066.GAU_0150 9.817e-12 73.0 2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl YYD2_k127_700776_0 1379698.RBG1_1C00001G1459 8.491e-161 515.0 COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria 2|Bacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N YYD2_k127_700776_2 1231057.AMGD01000013_gene1540 5.302e-117 383.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,26DE6@186818|Planococcaceae 91061|Bacilli I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain mmgB - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N YYD2_k127_700776_1 1379698.RBG1_1C00001G1458 1.345e-132 432.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N YYD2_k127_700776_3 1379698.RBG1_1C00001G1457 3.126e-116 386.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N YYD2_k127_700776_8 111781.Lepto7376_0500 1.509e-06 57.0 COG1943@1|root,COG1943@2|Bacteria,1G5Y7@1117|Cyanobacteria,1HCR7@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp YYD2_k127_791549_10 1121861.KB899924_gene3552 1.66e-15 83.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria,2JTAK@204441|Rhodospirillales 204441|Rhodospirillales S COG0517 FOG CBS domain - - - - - - - - - - - - CBS YYD2_k127_791549_3 1379698.RBG1_1C00001G1021 1.3e-86 294.0 COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 - R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf YYD2_k127_791549_6 1379698.RBG1_1C00001G1022 4.155e-41 163.0 COG4589@1|root,COG4589@2|Bacteria,2NPVB@2323|unclassified Bacteria 2|Bacteria S Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 YYD2_k127_791549_7 1379698.RBG1_1C00001G1024 1.384e-29 130.0 COG0382@1|root,COG0382@2|Bacteria,2NRJ9@2323|unclassified Bacteria 2|Bacteria H UbiA prenyltransferase family - - 2.5.1.133,2.5.1.39,2.5.1.62 ko:K03179,ko:K04040 ko00130,ko00860,ko01100,ko01110,map00130,map00860,map01100,map01110 M00117 R05000,R05615,R06284,R09067,R11514,R11517 RC00020,RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA YYD2_k127_791549_9 1382358.JHVN01000009_gene3326 4.281e-26 113.0 COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HH84@91061|Bacilli,21WTM@150247|Anoxybacillus 91061|Bacilli M NlpC/P60 family lytE - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SH3_3,SLH YYD2_k127_791549_1 1379698.RBG1_1C00001G1025 3.828e-199 638.0 COG0322@1|root,COG0322@2|Bacteria,2NNQ4@2323|unclassified Bacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N YYD2_k127_791549_2 1379698.RBG1_1C00001G1127 5.161e-103 349.0 COG1570@1|root,COG1570@2|Bacteria,2NNQT@2323|unclassified Bacteria 2|Bacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6,3.4.21.102 ko:K03601,ko:K03797 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko01002,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 YYD2_k127_791549_12 944481.JAFP01000001_gene1583 1.181e-09 61.0 COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2X2HT@28221|Deltaproteobacteria,2M7GT@213113|Desulfurellales 28221|Deltaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S YYD2_k127_791549_4 498761.HM1_0293 2.439e-81 280.0 COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia 186801|Clostridia H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt YYD2_k127_791549_0 1379698.RBG1_1C00001G1879 2.772e-220 702.0 COG1154@1|root,COG1154@2|Bacteria,2NNNA@2323|unclassified Bacteria 2|Bacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C YYD2_k127_791549_5 1379698.RBG1_1C00001G1130 3.923e-66 235.0 COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria 2|Bacteria G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895 NAD_kinase YYD2_k127_791549_11 28444.JODQ01000002_gene4223 4.418e-14 80.0 COG0457@1|root,COG0457@2|Bacteria,2H8D0@201174|Actinobacteria 201174|Actinobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - YYD2_k127_791549_8 945713.IALB_0910 2.159e-27 113.0 COG0050@1|root,COG0050@2|Bacteria 2|Bacteria J translation elongation factor activity tuf GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0010467,GO:0016020,GO:0019538,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0034641,GO:0034645,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0090087,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 - ko:K02358,ko:K15771 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147 3.A.1.1.16,3.A.1.1.2 - iSB619.SA_RS02960 GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 YYD2_k127_791701_1 1379698.RBG1_1C00001G1604 3.04e-78 265.0 COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 YYD2_k127_791701_2 1379698.RBG1_1C00001G1603 4.588e-63 218.0 COG0048@1|root,COG0048@2|Bacteria,2NPA7@2323|unclassified Bacteria 2|Bacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 YYD2_k127_791701_3 861299.J421_2770 1.831e-58 206.0 COG0049@1|root,COG0049@2|Bacteria,1ZSQZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 YYD2_k127_791701_0 1089550.ATTH01000001_gene2343 4.342e-280 878.0 COG0480@1|root,COG0480@2|Bacteria,4NE9X@976|Bacteroidetes,1FIQD@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 YYD2_k127_791701_4 945713.IALB_0910 5.392e-28 113.0 COG0050@1|root,COG0050@2|Bacteria 2|Bacteria J translation elongation factor activity tuf GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0010467,GO:0016020,GO:0019538,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0034641,GO:0034645,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0090087,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 - ko:K02358,ko:K15771 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147 3.A.1.1.16,3.A.1.1.2 - iSB619.SA_RS02960 GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 YYD2_k127_801327_3 1042326.AZNV01000068_gene5756 6.842e-22 111.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1NS2Y@1224|Proteobacteria,2UNZQ@28211|Alphaproteobacteria,4BI13@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc YYD2_k127_801327_2 593750.Metfor_0341 3.364e-24 119.0 arCOG03732@1|root,arCOG07676@1|root,arCOG09612@1|root,arCOG03732@2157|Archaea,arCOG07676@2157|Archaea,arCOG09612@2157|Archaea,2Y4EU@28890|Euryarchaeota 28890|Euryarchaeota S TIR domain - - - - - - - - - - - - TIR_2 YYD2_k127_801327_1 47763.JNZA01000035_gene2565 2.476e-46 186.0 COG0758@1|root,COG0758@2|Bacteria 2|Bacteria LU DNA mediated transformation smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A YYD2_k127_801327_0 1121920.AUAU01000018_gene1800 3.477e-164 529.0 COG0436@1|root,COG0436@2|Bacteria,3Y5C9@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class I and II - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD2_k127_805728_5 706587.Desti_5245 6.528e-41 151.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MQ8F@213462|Syntrophobacterales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 YYD2_k127_805728_8 861299.J421_2760 2.564e-17 82.0 COG0267@1|root,COG0267@2|Bacteria,1ZV8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L33 - - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 YYD2_k127_805728_9 1150626.PHAMO_320002 7.884e-12 68.0 COG0690@1|root,COG0690@2|Bacteria,1N75P@1224|Proteobacteria,2UF51@28211|Alphaproteobacteria,2JTWP@204441|Rhodospirillales 204441|Rhodospirillales U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE YYD2_k127_805728_3 1379698.RBG1_1C00001G1610 3.937e-77 261.0 COG0250@1|root,COG0250@2|Bacteria,2NPAP@2323|unclassified Bacteria 2|Bacteria K Participates in transcription elongation, termination and antitermination nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG YYD2_k127_805728_4 316067.Geob_3636 7.719e-59 207.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2WNAH@28221|Deltaproteobacteria,43UTJ@69541|Desulfuromonadales 28221|Deltaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N YYD2_k127_805728_2 1379698.RBG1_1C00001G1608 3.273e-85 287.0 COG0081@1|root,COG0081@2|Bacteria,2NNK6@2323|unclassified Bacteria 2|Bacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 YYD2_k127_805728_7 555088.DealDRAFT_1533 8.02e-34 136.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,42K2J@68298|Syntrophomonadaceae 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 YYD2_k127_805728_6 635013.TherJR_0286 5.831e-37 143.0 COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,26263@186807|Peptococcaceae 186801|Clostridia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N YYD2_k127_805728_0 880073.Calab_2119 0.0 1490.0 COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 YYD2_k127_805728_1 1379698.RBG1_1C00001G1604 0.0 1150.0 COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 YYD2_k127_809993_1 316067.Geob_3162 6.883e-13 76.0 2EUMZ@1|root,33N3U@2|Bacteria,1NUNW@1224|Proteobacteria,42ZFD@68525|delta/epsilon subdivisions,2WV00@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_809993_0 316067.Geob_3163 1.962e-15 84.0 COG4380@1|root,COG4380@2|Bacteria,1NJYS@1224|Proteobacteria,42X1E@68525|delta/epsilon subdivisions,2WTEE@28221|Deltaproteobacteria,43VPV@69541|Desulfuromonadales 28221|Deltaproteobacteria S Putative bacterial lipoprotein (DUF799) - - - - - - - - - - - - DUF799 YYD2_k127_809993_2 635013.TherJR_2221 2.686e-11 72.0 COG4409@1|root,COG4733@1|root,COG4409@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - ASH,BNR_2,CBM_35,DUF1080,F5_F8_type_C,PKD YYD2_k127_813041_2 1379698.RBG1_1C00001G1194 4.251e-76 292.0 COG2911@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - 3.2.1.91 ko:K14194,ko:K19668 ko00500,ko01100,ko02020,ko05150,map00500,map01100,map02020,map05150 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CHU_C,DUF11,FlgD_ig,PKD,SdrD_B YYD2_k127_813041_9 868595.Desca_2712 8.22e-25 109.0 COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,2620E@186807|Peptococcaceae 186801|Clostridia J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase YYD2_k127_813041_6 635013.TherJR_1960 1.077e-44 168.0 COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,24J8G@186801|Clostridia,2623P@186807|Peptococcaceae 186801|Clostridia S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 YYD2_k127_813041_1 1121468.AUBR01000030_gene1228 5.587e-97 327.0 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,42ENW@68295|Thermoanaerobacterales 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N YYD2_k127_813041_0 1379698.RBG1_1C00001G1432 1.23e-195 655.0 COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria 2|Bacteria D Required for chromosome condensation and partitioning smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03529,ko:K19171 - - - - ko00000,ko02048,ko03036 - - - SMC_N,SMC_hinge YYD2_k127_813041_13 864702.OsccyDRAFT_4029 6.105e-05 54.0 COG1426@1|root,COG1426@2|Bacteria,1G72S@1117|Cyanobacteria,1HBXP@1150|Oscillatoriales 1117|Cyanobacteria S Domain of unknown function (DUF4115) - - - - - - - - - - - - DUF4115,HTH_25 YYD2_k127_813041_7 1028307.EAE_04650 1.043e-40 158.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,3X0FQ@547|Enterobacter 1236|Gammaproteobacteria D Maf-like protein yhdE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf YYD2_k127_813041_5 1120973.AQXL01000101_gene1170 2.954e-45 168.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,278GH@186823|Alicyclobacillaceae 91061|Bacilli J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase YYD2_k127_813041_8 928724.SacglDRAFT_04376 5.059e-40 151.0 COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4E4EG@85010|Pseudonocardiales 201174|Actinobacteria O Belongs to the thioredoxin family trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin YYD2_k127_813041_4 1379698.RBG1_1C00001G1850 5.92e-64 229.0 COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria 2|Bacteria S Rhomboid family - - - - - - - - - - - - Rhomboid YYD2_k127_813041_11 1379698.RBG1_1C00001G1851 3.233e-13 81.0 COG3437@1|root,COG3437@2|Bacteria 2|Bacteria T response regulator, receiver - - 2.7.13.3 ko:K03407,ko:K07648,ko:K07679,ko:K11356 ko02020,ko02026,ko02030,ko05133,map02020,map02026,map02030,map05133 M00456,M00477,M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HTH_18,HisKA,Hpt,PAS_3,PAS_4,PAS_7,Reg_prop,Response_reg,Y_Y_Y YYD2_k127_813041_3 1379698.RBG1_1C00001G1619 1.17e-70 247.0 COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria 2|Bacteria O Cytochrome C biogenesis protein transmembrane region ccdA - 1.8.4.11,1.8.4.12 ko:K06196,ko:K12267 - - - - ko00000,ko01000,ko02000 5.A.1.2 - - AhpC-TSA,DsbD YYD2_k127_813041_12 1121904.ARBP01000001_gene5581 2.953e-11 73.0 COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,47PF2@768503|Cytophagia 976|Bacteroidetes S protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 YYD2_k127_813041_10 1340493.JNIF01000004_gene858 3.934e-22 99.0 COG1402@1|root,COG1402@2|Bacteria 2|Bacteria I creatininase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase YYD2_k127_84682_2 1379698.RBG1_1C00001G0964 4.008e-36 144.0 COG2050@1|root,COG2050@2|Bacteria,2NQ0Q@2323|unclassified Bacteria 2|Bacteria Q Thioesterase superfamily - - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - 4HBT YYD2_k127_84682_0 459349.CLOAM0099 1.206e-64 250.0 COG2234@1|root,COG2234@2|Bacteria,2NQ2F@2323|unclassified Bacteria 2|Bacteria S Peptidase family M28 - - 3.4.11.10 ko:K05994 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M28 YYD2_k127_84682_4 1444309.JAQG01000022_gene1478 0.0003055 52.0 COG1475@1|root,COG1475@2|Bacteria,1V8HN@1239|Firmicutes,4HJ7P@91061|Bacilli,272KB@186822|Paenibacillaceae 91061|Bacilli K ParB-like nuclease domain - - - - - - - - - - - - ParBc YYD2_k127_84682_3 525367.HMPREF0556_12327 4.553e-09 60.0 COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,4HNJS@91061|Bacilli,26KZ6@186820|Listeriaceae 91061|Bacilli J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p YYD2_k127_84682_1 1379698.RBG1_1C00001G1752 3.61e-60 215.0 COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria 2|Bacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN YYD2_k127_861546_3 1173028.ANKO01000161_gene5040 5.541e-56 226.0 COG2202@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1GHCI@1117|Cyanobacteria,1HARB@1150|Oscillatoriales 1117|Cyanobacteria T His Kinase A (phosphoacceptor) domain - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF,GGDEF,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9 YYD2_k127_861546_0 338966.Ppro_3003 2.529e-152 494.0 COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria,43T88@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Xanthine uracil vitamin C permease pbuG - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease YYD2_k127_861546_1 215803.DB30_2841 1.169e-144 472.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions,2WJ6Q@28221|Deltaproteobacteria,2YWF8@29|Myxococcales 28221|Deltaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 YYD2_k127_861546_2 1379698.RBG1_1C00001G1677 7.041e-113 373.0 COG3239@1|root,COG3239@2|Bacteria,2NNTZ@2323|unclassified Bacteria 2|Bacteria I Fatty acid desaturase des - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase YYD2_k127_861546_4 1049564.TevJSym_ad00590 3.212e-55 199.0 COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,1RPV0@1236|Gammaproteobacteria,1J68H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MarC family integral membrane protein yhgN GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC YYD2_k127_861546_5 945713.IALB_0468 1.547e-46 173.0 2BN55@1|root,33HC1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD2_k127_861546_7 1304885.AUEY01000038_gene2578 1.936e-32 130.0 COG1832@1|root,COG1832@2|Bacteria,1PUW7@1224|Proteobacteria,42T5D@68525|delta/epsilon subdivisions,2WPHZ@28221|Deltaproteobacteria,2MK69@213118|Desulfobacterales 28221|Deltaproteobacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 YYD2_k127_861546_6 1191523.MROS_1700 5.326e-45 165.0 COG0648@1|root,COG0648@2|Bacteria 2|Bacteria L deoxyribonuclease IV (phage-T4-induced) activity nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 YYD2_k127_882272_0 945713.IALB_0724 5.136e-90 305.0 COG0348@1|root,COG0348@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding ccoG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_18,Fer4_5,FixG_C YYD2_k127_882272_2 945713.IALB_0725 3.73e-24 108.0 COG5456@1|root,COG5456@2|Bacteria 2|Bacteria P FixH fixH - - - - - - - - - - - FixH YYD2_k127_882272_1 945713.IALB_0726 5.035e-56 205.0 COG2836@1|root,COG2836@2|Bacteria 2|Bacteria K Biogenesis protein braZ - - ko:K09792 - - - - ko00000 - - - DsbD_2,Ferric_reduct YYD2_k127_894624_2 1379698.RBG1_1C00001G1090 1.205e-62 227.0 COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 YYD2_k127_894624_1 1125863.JAFN01000001_gene3034 1.612e-77 279.0 COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria 28221|Deltaproteobacteria T metal-dependent phosphohydrolase HD region - - - - - - - - - - - - GAF_2,GAF_3,HD,Response_reg YYD2_k127_894624_0 1408823.AXUS01000020_gene2131 6.22e-91 309.0 COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia 186801|Clostridia H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM YYD2_k127_894624_4 1379698.RBG1_1C00001G0540 7.832e-05 56.0 COG1520@1|root,COG1520@2|Bacteria,2NQ51@2323|unclassified Bacteria 2|Bacteria O NHL repeat containing protein - - - - - - - - - - - - PQQ_2,SBBP YYD2_k127_894624_3 1121930.AQXG01000004_gene2869 1.687e-25 122.0 COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity prtA - 3.2.1.23,3.4.24.40 ko:K01190,ko:K01406,ko:K07004,ko:K13277 ko00052,ko00511,ko00600,ko01100,ko01503,ko02024,map00052,map00511,map00600,map01100,map01503,map02024 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000,ko01002,ko03110 - - - Gram_pos_anchor,HemolysinCabind,PA,Peptidase_S8,SLH,fn3_5 YYD2_k127_896646_13 1211814.CAPG01000010_gene342 1.045e-06 55.0 COG1514@1|root,COG1514@2|Bacteria,1V2F3@1239|Firmicutes,4HG6P@91061|Bacilli,1ZG9R@1386|Bacillus 91061|Bacilli J Belongs to the 2H phosphoesterase superfamily. YjcG family yjcG - - - - - - - - - - - 2_5_RNA_ligase2 YYD2_k127_896646_9 1123256.KB907928_gene2150 9.481e-42 171.0 COG2885@1|root,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,1RP3K@1236|Gammaproteobacteria,1X9H3@135614|Xanthomonadales 135614|Xanthomonadales M OmpA family - - - - - - - - - - - - OmpA,TSP_3 YYD2_k127_896646_5 1379698.RBG1_1C00001G0322 2.332e-72 259.0 COG2385@1|root,COG2385@2|Bacteria,2NPRR@2323|unclassified Bacteria 2|Bacteria D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID YYD2_k127_896646_6 1379698.RBG1_1C00001G0323 5.183e-63 232.0 COG2377@1|root,COG2377@2|Bacteria,2NNMN@2323|unclassified Bacteria 2|Bacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170,4.2.1.126 ko:K07106,ko:K09001 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032 AnmK YYD2_k127_896646_7 941449.dsx2_1776 2.013e-57 213.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2WN0Z@28221|Deltaproteobacteria,2MGBG@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM glycoside hydrolase family 3 nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C YYD2_k127_896646_3 1379698.RBG1_1C00001G0325 3.474e-90 316.0 COG2199@1|root,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria 2|Bacteria T diguanylate cyclase - - - - - - - - - - - - GAF,GAF_2,GAF_3,GGDEF,MASE3,PAS_3,PAS_4,Response_reg YYD2_k127_896646_0 671143.DAMO_0012 5.549e-211 669.0 COG1966@1|root,COG1966@2|Bacteria,2NNP2@2323|unclassified Bacteria 2|Bacteria T 5TM C-terminal transporter carbon starvation CstA cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM YYD2_k127_896646_15 189753.AXAS01000004_gene934 1.003e-05 54.0 2EH3D@1|root,33AVD@2|Bacteria,1QR7N@1224|Proteobacteria,2TUZ2@28211|Alphaproteobacteria,3JXFI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3592) - - - - - - - - - - - - DUF3592 YYD2_k127_896646_10 1379698.RBG1_1C00001G0327 1.395e-35 151.0 COG1664@1|root,COG1664@2|Bacteria 2|Bacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin YYD2_k127_896646_4 99598.Cal7507_6086 3.366e-74 256.0 COG3548@1|root,COG3548@2|Bacteria,1GKP7@1117|Cyanobacteria,1HRK3@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function (DUF1211) - - - - - - - - - - - - DUF1211 YYD2_k127_896646_8 1379698.RBG1_1C00001G0781 3.396e-46 171.0 COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria 2|Bacteria C Rieske [2Fe-2S] domain petA - 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske,UCR_Fe-S_N YYD2_k127_896646_1 671143.DAMO_0821 3.991e-126 415.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B YYD2_k127_896646_2 671143.DAMO_0822 6.804e-93 321.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB YYD2_k127_896646_14 1408444.JHYC01000008_gene1427 7.923e-06 49.0 2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD2_k127_896646_12 1120983.KB894570_gene1233 8.324e-22 100.0 COG2050@1|root,COG2050@2|Bacteria,1PP3V@1224|Proteobacteria,2UVNH@28211|Alphaproteobacteria,1JPJM@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT YYD2_k127_896646_11 404380.Gbem_1094 1.497e-26 124.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43E1J@68525|delta/epsilon subdivisions,2WM21@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA YYD2_k127_904715_1 1121472.AQWN01000001_gene239 2.969e-47 178.0 COG2859@1|root,COG2859@2|Bacteria,1V1Q4@1239|Firmicutes,24GEE@186801|Clostridia,264GJ@186807|Peptococcaceae 186801|Clostridia S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL YYD2_k127_904715_0 608506.COB47_1150 7.728e-173 550.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,42ER3@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N YYD2_k127_931391_0 1408445.JHXP01000001_gene1663 5.266e-79 278.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,1JDG7@118969|Legionellales 118969|Legionellales O Peptidase family M13 pepO - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N YYD2_k127_931391_1 1403819.BATR01000133_gene4708 2.027e-71 244.0 COG3832@1|root,COG3832@2|Bacteria,46SRI@74201|Verrucomicrobia,2IVPS@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 YYD2_k127_931391_2 604354.TSIB_1715 1.071e-11 69.0 COG1832@1|root,arCOG04227@2157|Archaea,2XX68@28890|Euryarchaeota,245H1@183968|Thermococci 183968|Thermococci S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 YYD2_k127_97336_2 742817.HMPREF9449_01592 4.689e-57 203.0 COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,2FQQ7@200643|Bacteroidia,22WBS@171551|Porphyromonadaceae 976|Bacteroidetes C 1-pyrroline-5-carboxylate dehydrogenase pruA - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh YYD2_k127_97336_0 553217.ENHAE0001_1916 2.189e-145 480.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,3NIUX@468|Moraxellaceae 1236|Gammaproteobacteria M Gamma-glutamyltranspeptidase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept YYD2_k127_97336_1 1379698.RBG1_1C00001G0595 1.257e-141 475.0 COG1874@1|root,COG1874@2|Bacteria,2NRR5@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolases family 35 - - 3.2.1.23 ko:K01190,ko:K12308 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Cellulase,Glyco_hydro_35,Glyco_hydro_42,Glyco_hydro_42M,Sulfotransfer_2 YYD2_k127_97336_4 880073.Calab_0123 3.61e-28 126.0 COG2319@1|root,COG2319@2|Bacteria 2|Bacteria S anaphase-promoting complex binding - - - - - - - - - - - - Lectin_legB,NB-ARC,TIR_2,WD40 YYD2_k127_97336_3 755732.Fluta_1682 2.977e-40 167.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,4PI0A@976|Bacteroidetes,1IMVQ@117743|Flavobacteriia,2PBY2@246874|Cryomorphaceae 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 ## 2515 queries scanned ## Total time (seconds): 8.93326449394226 ## Rate: 281.53 q/s