## Tue Mar 18 01:42:29 2025 ## emapper-2.1.9 ## /home/zhangkaihang/.conda/envs/eggnog-mapper/bin/emapper.py -i /home/zhangkaihang/metadata_analysis/metawrap/paddysoil/4paddy/bin4gtdbtk/YYD3_bin.4.fa -m mmseqs --itype genome -o YYD3_bin.4 --output_dir /home/zhangkaihang/metadata_analysis/eggnog-mapper/paddysoil/4paddy/YYD3_bin.4 --cpu 8 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs YYD3_k127_1001209_2 370438.PTH_1770 1.154e-188 601.0 COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,26067@186807|Peptococcaceae 186801|Clostridia Q PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal - - 1.14.14.9,4.2.1.120,5.3.3.3 ko:K00483,ko:K14534 ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220 M00374,M00375 R02698,R03031,R03299,R10782 RC00046,RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N YYD3_k127_1001209_9 1379698.RBG1_1C00001G0828 7.342e-10 67.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin,Thioredoxin YYD3_k127_1001209_3 945713.IALB_1809 3.009e-113 373.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K00571,ko:K03497 - - - - ko00000,ko01000,ko02048,ko03000,ko03036,ko04812 - - - N6_N4_Mtase,ParBc,RE_Eco29kI YYD3_k127_1001209_5 1379698.RBG1_1C00001G0342 5.755e-64 227.0 COG2908@1|root,COG2908@2|Bacteria,2NPKW@2323|unclassified Bacteria 2|Bacteria S Calcineurin-like phosphoesterase lpxH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - iE2348C_1286.E2348C_0457 Metallophos,Metallophos_2 YYD3_k127_1001209_0 1379698.RBG1_1C00001G0338 6.345e-315 980.0 COG0046@1|root,COG0046@2|Bacteria,2NNPS@2323|unclassified Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C YYD3_k127_1001209_4 1379698.RBG1_1C00001G1629 1.199e-68 251.0 COG0037@1|root,COG0037@2|Bacteria,2NPAZ@2323|unclassified Bacteria 2|Bacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS_C YYD3_k127_1001209_7 396014.BF93_03070 3.077e-40 155.0 COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4FB8Y@85020|Dermabacteraceae 201174|Actinobacteria F Phosphoribosyl transferase domain hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran YYD3_k127_1001209_1 1379698.RBG1_1C00001G1627 9.881e-263 824.0 COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria 2|Bacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 YYD3_k127_1001209_6 648996.Theam_1364 7.275e-63 222.0 COG0302@1|root,COG0302@2|Bacteria,2G40B@200783|Aquificae 200783|Aquificae H GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI YYD3_k127_1001209_8 1205753.A989_14957 1.643e-28 118.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1X3ZA@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind YYD3_k127_1001491_2 886379.AEWI01000001_gene1646 2.835e-08 66.0 COG1480@1|root,COG1480@2|Bacteria,4NEHV@976|Bacteroidetes,2FNT9@200643|Bacteroidia,3XJ9D@558415|Marinilabiliaceae 976|Bacteroidetes S 7TM-HD extracellular - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD YYD3_k127_1001491_1 644966.Tmar_2172 2.23e-108 362.0 COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,3WCEH@538999|Clostridiales incertae sedis 186801|Clostridia T PhoH-like protein phoH - - ko:K06217 - - - - ko00000 - - - PhoH YYD3_k127_1001491_0 1379698.RBG1_1C00001G0606 6.444e-227 720.0 COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria 2|Bacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN678.aspS,iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon YYD3_k127_1003176_0 91464.S7335_4653 1.15e-158 512.0 COG1252@1|root,COG1252@2|Bacteria,1G20T@1117|Cyanobacteria,1GZB9@1129|Synechococcus 1117|Cyanobacteria C NADH dehydrogenase ndbA - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 YYD3_k127_1003176_2 926556.Echvi_0018 7.608e-63 223.0 COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,47PDZ@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA,PD40 YYD3_k127_1003176_4 1305836.AXVE01000012_gene42 2.057e-21 97.0 COG0346@1|root,COG0346@2|Bacteria,1W3B2@1239|Firmicutes,4I26F@91061|Bacilli,26HZ5@186818|Planococcaceae 91061|Bacilli E lactoylglutathione lyase activity - - - - - - - - - - - - - YYD3_k127_1003176_3 880072.Desac_0212 1.182e-61 216.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,2MRIV@213462|Syntrophobacterales 28221|Deltaproteobacteria M Large-conductance mechanosensitive channel, MscL mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL YYD3_k127_1003176_1 1337936.IJ00_19060 3.518e-91 308.0 COG0412@1|root,COG0412@2|Bacteria,1G4HV@1117|Cyanobacteria,1HMQR@1161|Nostocales 1117|Cyanobacteria Q dienelactone hydrolase - - - - - - - - - - - - DLH YYD3_k127_1003176_5 634177.GLX_11690 0.0001273 45.0 COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria,2JWSG@204441|Rhodospirillales 204441|Rhodospirillales T GAF domain - - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 YYD3_k127_1015350_1 1382306.JNIM01000001_gene3926 1.688e-19 93.0 COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi 200795|Chloroflexi J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C YYD3_k127_1015350_0 269798.CHU_1442 2.716e-100 357.0 COG0308@1|root,COG0308@2|Bacteria,4NEXH@976|Bacteroidetes,47JGQ@768503|Cytophagia 976|Bacteroidetes E PFAM Peptidase M1, membrane alanine aminopeptidase - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M1 YYD3_k127_1025503_3 1111479.AXAR01000013_gene3012 5.737e-30 121.0 COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,4HIV1@91061|Bacilli 91061|Bacilli H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox YYD3_k127_1025503_1 1121121.KB894301_gene2208 1.863e-62 224.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H9V5@91061|Bacilli,26RIB@186822|Paenibacillaceae 91061|Bacilli M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase YYD3_k127_1025503_2 1379698.RBG1_1C00001G0311 6.734e-32 129.0 COG0799@1|root,COG0799@2|Bacteria,2NPYI@2323|unclassified Bacteria 2|Bacteria S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RsfS YYD3_k127_1025503_0 1379698.RBG1_1C00001G0312 2.071e-215 676.0 COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria 2|Bacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind YYD3_k127_1038225_1 1184267.A11Q_1772 2.15e-07 60.0 COG3911@1|root,COG3911@2|Bacteria 2|Bacteria K COG3911 Predicted ATPase - - - - - - - - - - - - AAA_28 YYD3_k127_1038225_0 1379698.RBG1_1C00001G0715 9.606e-116 384.0 COG0006@1|root,COG0006@2|Bacteria 2|Bacteria E proline dipeptidase activity - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 YYD3_k127_104265_0 439235.Dalk_3953 1.633e-45 184.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase nifM - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 YYD3_k127_104265_1 880073.Calab_1320 5.787e-45 186.0 COG0739@1|root,COG0739@2|Bacteria,2NR6F@2323|unclassified Bacteria 2|Bacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 YYD3_k127_104265_2 1379698.RBG1_1C00001G0457 3.318e-42 160.0 COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria 2|Bacteria S (Rhomboid) family GlpG - - ko:K07059 - - - - ko00000 - - - Rhomboid YYD3_k127_1045975_1 1379698.RBG1_1C00001G1742 8.9e-141 453.0 COG2805@1|root,COG2805@2|Bacteria,2NNR7@2323|unclassified Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE YYD3_k127_1045975_0 1379698.RBG1_1C00001G1743 1.916e-177 563.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain pilB - - ko:K02454,ko:K02504,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N YYD3_k127_1051488_1 673860.AciM339_0881 1.339e-77 263.0 COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,3F2NP@33867|unclassified Euryarchaeota 28890|Euryarchaeota C Isocitrate/isopropylmalate dehydrogenase leuB GO:0006082,GO:0006575,GO:0006732,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0019297,GO:0019298,GO:0019752,GO:0032787,GO:0042398,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 1.1.1.85,1.1.1.87 ko:K00052,ko:K10978 ko00290,ko00300,ko00660,ko00680,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00680,map01100,map01110,map01120,map01130,map01210,map01230 M00432,M00535,M00608 R00994,R01934,R01936,R04426,R04862,R08214,R08215,R10052 RC00084,RC00114,RC00417,RC00626,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh YYD3_k127_1051488_0 1131462.DCF50_p308 5.059e-165 530.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae 186801|Clostridia C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C YYD3_k127_1072001_1 316067.Geob_1919 3.071e-110 372.0 COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria,42MZ1@68525|delta/epsilon subdivisions,2WMHA@28221|Deltaproteobacteria,43U2K@69541|Desulfuromonadales 28221|Deltaproteobacteria G PFAM alpha amylase catalytic region - - - - - - - - - - - - Alpha-amylase YYD3_k127_1072001_4 1265503.KB905181_gene3773 1.699e-11 72.0 2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,1SDBT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4154) - - - - - - - - - - - - DUF4154 YYD3_k127_1072001_2 404380.Gbem_0798 2.421e-67 250.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42NXX@68525|delta/epsilon subdivisions 1224|Proteobacteria NT methyl-accepting chemotaxis protein difA - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal YYD3_k127_1072001_3 1121904.ARBP01000011_gene1396 3.756e-20 105.0 COG1404@1|root,COG1572@1|root,COG3291@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,COG3291@2|Bacteria,4NF1M@976|Bacteroidetes,47NC9@768503|Cytophagia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 YYD3_k127_1072001_0 1379270.AUXF01000002_gene1557 3.428e-158 518.0 COG2091@1|root,COG2091@2|Bacteria,1ZUQA@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - YYD3_k127_1091226_3 869213.JCM21142_104169 8.631e-09 57.0 COG3256@1|root,COG3256@2|Bacteria,4NG9H@976|Bacteroidetes,47K63@768503|Cytophagia 976|Bacteroidetes P Cytochrome C and Quinol oxidase polypeptide I - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 YYD3_k127_1091226_0 1379698.RBG1_1C00001G1076 0.0 1410.0 COG3696@1|root,COG3696@2|Bacteria,2NP07@2323|unclassified Bacteria 2|Bacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran YYD3_k127_1091226_1 1379698.RBG1_1C00001G1075 2.758e-147 481.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 YYD3_k127_1091226_2 1382358.JHVN01000007_gene307 3.383e-114 379.0 COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,4HA9W@91061|Bacilli,21V54@150247|Anoxybacillus 1239|Firmicutes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N YYD3_k127_1093159_1 1379698.RBG1_1C00001G0410 4.915e-50 184.0 COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria 2|Bacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 YYD3_k127_1093159_0 324925.Ppha_0080 3.874e-105 353.0 COG0743@1|root,COG0743@2|Bacteria,1FD70@1090|Chlorobi 1090|Chlorobi I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom YYD3_k127_1093159_2 497964.CfE428DRAFT_2964 6.975e-45 170.0 COG0652@1|root,COG0652@2|Bacteria,46VEN@74201|Verrucomicrobia 74201|Verrucomicrobia O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase YYD3_k127_1093159_3 448385.sce6636 1.864e-17 87.0 COG0262@1|root,COG0262@2|Bacteria,1R7YJ@1224|Proteobacteria,438N0@68525|delta/epsilon subdivisions,2X3W2@28221|Deltaproteobacteria,2YXB2@29|Myxococcales 28221|Deltaproteobacteria H RibD C-terminal domain - - - - - - - - - - - - RibD_C YYD3_k127_1103216_1 935948.KE386494_gene842 2.007e-50 186.0 COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,42GBY@68295|Thermoanaerobacterales 186801|Clostridia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin YYD3_k127_1103216_0 1379698.RBG1_1C00001G1839 4.231e-54 209.0 COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 YYD3_k127_1103216_2 278957.ABEA03000006_gene4188 4.63e-33 138.0 COG0730@1|root,COG0730@2|Bacteria,46V52@74201|Verrucomicrobia,3K9AP@414999|Opitutae 414999|Opitutae S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE YYD3_k127_116000_0 479434.Sthe_0112 2.287e-66 233.0 COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi,27YZ2@189775|Thermomicrobia 189775|Thermomicrobia I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N YYD3_k127_116000_2 868131.MSWAN_2301 5.497e-28 119.0 COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23P3X@183925|Methanobacteria 183925|Methanobacteria V DUF35 OB-fold domain, acyl-CoA-associated - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc YYD3_k127_116000_3 304371.MCP_1737 5.643e-21 96.0 COG5646@1|root,arCOG09457@2157|Archaea,2Y1ED@28890|Euryarchaeota 28890|Euryarchaeota S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 YYD3_k127_116000_6 1382359.JIAL01000001_gene198 1.761e-11 68.0 2E34G@1|root,32Y4J@2|Bacteria,3Y5JB@57723|Acidobacteria,2JJW7@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - YYD3_k127_116000_4 96561.Dole_2317 7.926e-16 79.0 2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,42WYZ@68525|delta/epsilon subdivisions,2WT48@28221|Deltaproteobacteria,2MPCB@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_116000_5 459349.CLOAM0604 3.755e-15 78.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_116420_0 219305.MCAG_05245 1.293e-132 430.0 COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4DAXK@85008|Micromonosporales 201174|Actinobacteria EK Cystathionine beta-synthase - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP YYD3_k127_116420_1 316274.Haur_1551 6.191e-23 109.0 COG1496@1|root,COG1496@2|Bacteria,2G6N5@200795|Chloroflexi 200795|Chloroflexi S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 YYD3_k127_1188296_0 945713.IALB_0759 1.753e-59 218.0 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - PorP_SprF YYD3_k127_1196542_1 215803.DB30_0085 1.757e-20 97.0 COG3746@1|root,COG3746@2|Bacteria,1PBWD@1224|Proteobacteria,433TT@68525|delta/epsilon subdivisions,2X3F8@28221|Deltaproteobacteria,2YVU2@29|Myxococcales 28221|Deltaproteobacteria P phosphate-selective porin O and P - - - - - - - - - - - - - YYD3_k127_1196542_0 215803.DB30_0086 9.203e-103 341.0 COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria,2YVQ5@29|Myxococcales 28221|Deltaproteobacteria P PBP superfamily domain - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 YYD3_k127_1197101_1 1379698.RBG1_1C00001G0476 2.341e-84 286.0 COG0074@1|root,COG0074@2|Bacteria,2NNZD@2323|unclassified Bacteria 2|Bacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA YYD3_k127_1197101_0 1379698.RBG1_1C00001G0475 8.738e-145 467.0 COG0045@1|root,COG0045@2|Bacteria,2NNQA@2323|unclassified Bacteria 2|Bacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009361,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0042709,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494 6.2.1.5,6.2.1.9 ko:K01903,ko:K14067 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2261,iPC815.YPO1115,iUMNK88_1353.UMNK88_764,iYO844.BSU16090 ATP-grasp_2,Ligase_CoA YYD3_k127_1197101_2 1379698.RBG1_1C00001G0474 1.236e-49 183.0 COG0617@1|root,COG0617@2|Bacteria,2NPB4@2323|unclassified Bacteria 2|Bacteria J Poly A polymerase head domain cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 YYD3_k127_1217965_10 485913.Krac_10312 9.439e-37 141.0 COG0177@1|root,COG0177@2|Bacteria,2G6A1@200795|Chloroflexi 200795|Chloroflexi L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD YYD3_k127_1217965_9 869213.JCM21142_72957 2.441e-37 146.0 2A42S@1|root,30SMP@2|Bacteria,4P40W@976|Bacteroidetes 976|Bacteroidetes S Nickel-containing superoxide dismutase - - - - - - - - - - - - Sod_Ni YYD3_k127_1217965_12 247490.KSU1_C0709 3.802e-29 124.0 COG1633@1|root,COG1633@2|Bacteria,2J3M5@203682|Planctomycetes 203682|Planctomycetes S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD3_k127_1217965_13 880073.Calab_2419 1.347e-23 113.0 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - Big_5 YYD3_k127_1217965_4 1499967.BAYZ01000074_gene2192 3.071e-46 178.0 COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria 2|Bacteria M Lipid A biosynthesis - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans YYD3_k127_1217965_8 1499967.BAYZ01000118_gene3248 1.327e-39 163.0 COG0845@1|root,COG0845@2|Bacteria,2NR8R@2323|unclassified Bacteria 2|Bacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K02005 - - - - ko00000 - - - HlyD_3,HlyD_D23 YYD3_k127_1217965_3 1336233.JAEH01000015_gene3232 5.628e-94 323.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1RMBY@1236|Gammaproteobacteria,2QAXR@267890|Shewanellaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD3_k127_1217965_15 471870.BACINT_02916 1.53e-10 74.0 COG1538@1|root,COG1538@2|Bacteria,4NGXM@976|Bacteroidetes,2FMD9@200643|Bacteroidia,4AKU0@815|Bacteroidaceae 976|Bacteroidetes MU Psort location OuterMembrane, score - - - - - - - - - - - - OEP YYD3_k127_1217965_5 398767.Glov_0772 6.604e-45 176.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,43S6D@69541|Desulfuromonadales 28221|Deltaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 YYD3_k127_1217965_11 1379698.RBG1_1C00001G1508 4.805e-34 133.0 2E4KV@1|root,32ZFU@2|Bacteria,2NQ0D@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF3467) - - - - - - - - - - - - DUF3467 YYD3_k127_1217965_2 1379698.RBG1_1C00001G1507 1.266e-98 334.0 COG2870@1|root,COG2870@2|Bacteria,2NNUT@2323|unclassified Bacteria 2|Bacteria M pfkB family carbohydrate kinase rfaE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB YYD3_k127_1217965_6 667014.Thein_1023 6.78e-45 168.0 COG0388@1|root,COG0615@1|root,COG0388@2|Bacteria,COG0615@2|Bacteria,2GHDJ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria IM Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - - - - - - - - - - CN_hydrolase,CTP_transf_like YYD3_k127_1217965_14 379066.GAU_1928 1.353e-14 81.0 COG0457@1|root,COG0457@2|Bacteria,1ZTTU@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 YYD3_k127_1217965_1 1379698.RBG1_1C00001G1504 4.803e-104 349.0 COG0006@1|root,COG0006@2|Bacteria,2NP41@2323|unclassified Bacteria 2|Bacteria E Creatinase/Prolidase N-terminal domain pepP - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 YYD3_k127_1217965_7 1379698.RBG1_1C00001G1503 3.43e-40 154.0 COG0511@1|root,COG0511@2|Bacteria,2NPT1@2323|unclassified Bacteria 2|Bacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - 2.3.1.12,4.1.1.3 ko:K00627,ko:K01571,ko:K02160 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00307,M00376 R00209,R00217,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - iHN637.CLJU_RS20755 Biotin_lipoyl YYD3_k127_1217965_0 1379698.RBG1_1C00001G1502 3.565e-164 525.0 COG2805@1|root,COG2805@2|Bacteria,2NP0T@2323|unclassified Bacteria 2|Bacteria NU Type II/IV secretion system protein pilT-1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE YYD3_k127_128279_3 880073.Calab_2052 8.672e-28 114.0 COG1837@1|root,COG1837@2|Bacteria,2NPUP@2323|unclassified Bacteria 2|Bacteria S Belongs to the UPF0109 family ylqC - - ko:K06960 - - - - ko00000 - - - KH_4 YYD3_k127_128279_2 767817.Desgi_2744 8.539e-30 124.0 COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,2623V@186807|Peptococcaceae 186801|Clostridia J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM YYD3_k127_128279_0 1379698.RBG1_1C00001G0950 3.809e-74 258.0 COG0336@1|root,COG0336@2|Bacteria,2NP5G@2323|unclassified Bacteria 2|Bacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 - - - tRNA_m1G_MT YYD3_k127_128279_1 679201.HMPREF9334_01805 1.054e-41 156.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4H4PC@909932|Negativicutes 909932|Negativicutes J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 YYD3_k127_1293916_0 1379698.RBG1_1C00001G1432 7.3e-92 317.0 COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria 2|Bacteria D Required for chromosome condensation and partitioning smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03529,ko:K19171 - - - - ko00000,ko02048,ko03036 - - - SMC_N,SMC_hinge YYD3_k127_1293916_5 864702.OsccyDRAFT_4029 6.105e-05 54.0 COG1426@1|root,COG1426@2|Bacteria,1G72S@1117|Cyanobacteria,1HBXP@1150|Oscillatoriales 1117|Cyanobacteria S Domain of unknown function (DUF4115) - - - - - - - - - - - - DUF4115,HTH_25 YYD3_k127_1293916_2 1028307.EAE_04650 1.043e-40 158.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,3X0FQ@547|Enterobacter 1236|Gammaproteobacteria D Maf-like protein yhdE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf YYD3_k127_1293916_1 1120973.AQXL01000101_gene1170 6.108e-46 170.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,4HINN@91061|Bacilli,278GH@186823|Alicyclobacillaceae 91061|Bacilli J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase YYD3_k127_1293916_3 928724.SacglDRAFT_04376 6.345e-39 147.0 COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4E4EG@85010|Pseudonocardiales 201174|Actinobacteria O Belongs to the thioredoxin family trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin YYD3_k127_1293916_4 1379698.RBG1_1C00001G1850 3.002e-05 48.0 COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria 2|Bacteria S Rhomboid family - - - - - - - - - - - - Rhomboid YYD3_k127_1293916_6 234267.Acid_2745 0.0001075 47.0 COG0082@1|root,COG0082@2|Bacteria,3Y2Z8@57723|Acidobacteria 57723|Acidobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt YYD3_k127_1303315_1 1379698.RBG1_1C00001G1819 2.026e-161 540.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_1303315_2 1379698.RBG1_1C00001G1819 1.791e-159 535.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_1303315_4 1089550.ATTH01000001_gene1066 2.811e-126 430.0 COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,1FJZ6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD3_k127_1303315_3 639030.JHVA01000001_gene3842 5.053e-135 446.0 COG0612@1|root,COG0612@2|Bacteria,3Y3XF@57723|Acidobacteria,2JHR4@204432|Acidobacteriia 204432|Acidobacteriia S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD3_k127_1303315_5 1444309.JAQG01000164_gene1837 7.801e-124 421.0 COG2304@1|root,COG2304@2|Bacteria,1TSU7@1239|Firmicutes,4HPXN@91061|Bacilli 91061|Bacilli S Domain of unknown function (DUF3520) - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A YYD3_k127_1303315_0 545695.TREAZ_1620 1.33e-269 853.0 COG0058@1|root,COG0058@2|Bacteria,2J5KC@203691|Spirochaetes 203691|Spirochaetes G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties malP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase YYD3_k127_1317022_3 1379698.RBG1_1C00001G1680 2.261e-133 433.0 COG0513@1|root,COG0513@2|Bacteria,2NP0A@2323|unclassified Bacteria 2|Bacteria JKL Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C YYD3_k127_1317022_0 234267.Acid_5940 8.537e-235 754.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase YYD3_k127_1317022_1 1047013.AQSP01000093_gene11 2.516e-178 566.0 COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 YYD3_k127_1317022_2 1047013.AQSP01000077_gene2274 2.72e-149 481.0 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 YYD3_k127_1335438_4 945713.IALB_2312 9.175e-09 56.0 COG5563@1|root,COG5563@2|Bacteria 2|Bacteria - - CP_1072 - - - - - - - - - - - Autotransporter YYD3_k127_1335438_1 1121957.ATVL01000006_gene3165 2.778e-57 205.0 COG0454@1|root,COG0456@2|Bacteria,4NQ7Z@976|Bacteroidetes,47QG5@768503|Cytophagia 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - - ko:K03829 - - - - ko00000,ko01000 - - - Acetyltransf_1 YYD3_k127_1335438_3 1379698.RBG1_1C00001G0105 2.265e-25 113.0 COG0597@1|root,COG0597@2|Bacteria,2NPU1@2323|unclassified Bacteria 2|Bacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 YYD3_k127_1335438_2 1379698.RBG1_1C00001G0104 3.147e-46 169.0 COG1734@1|root,COG1734@2|Bacteria,2NPX2@2323|unclassified Bacteria 2|Bacteria T Transcriptional regulator, TraR DksA family dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR YYD3_k127_1335438_0 555079.Toce_1642 2.84e-277 880.0 COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,42F4D@68295|Thermoanaerobacterales 186801|Clostridia J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS YYD3_k127_1346980_1 1492738.FEM21_15700 2.487e-43 162.0 COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,1I24B@117743|Flavobacteriia,2NVW1@237|Flavobacterium 976|Bacteroidetes G Ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB YYD3_k127_1346980_0 204669.Acid345_0712 3.019e-128 417.0 COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 YYD3_k127_1346980_2 1382356.JQMP01000001_gene1206 9.719e-23 100.0 COG1268@1|root,COG1268@2|Bacteria,2GBUZ@200795|Chloroflexi,27YWE@189775|Thermomicrobia 189775|Thermomicrobia S BioY family - - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY YYD3_k127_1350895_0 945713.IALB_2321 1.875e-108 375.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process pepN1 - - - - - - - - - - - Peptidase_M1 YYD3_k127_137516_0 933262.AXAM01000020_gene23 2.555e-138 449.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MHS8@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG YYD3_k127_137516_1 1125863.JAFN01000001_gene1341 1.198e-43 165.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2WJ8I@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG YYD3_k127_1384392_0 1379698.RBG1_1C00001G0885 5.491e-60 213.0 COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria 2|Bacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338,ko:K08675 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002,ko03029 - - - AAA,LON_substr_bdg,Lon_C YYD3_k127_1384392_1 1380390.JIAT01000014_gene6288 3.005e-40 169.0 COG0028@1|root,COG0515@1|root,COG1470@1|root,COG2133@1|root,COG3291@1|root,COG0028@2|Bacteria,COG0515@2|Bacteria,COG1470@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - Calx-beta,DUF4347,GSDH,Laminin_G_3,PA14,PKD YYD3_k127_1386105_0 1379698.RBG1_1C00001G0844 1.734e-163 524.0 COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria 2|Bacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECUMN_1333.ECUMN_0566,iJN746.PP_2905,iNJ661.Rv2130c DALR_2,tRNA-synt_1e,tRNA-synt_1g YYD3_k127_1386105_1 754476.Q7A_1079 1.437e-131 430.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,4601V@72273|Thiotrichales 72273|Thiotrichales M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd YYD3_k127_1386105_2 1440052.EAKF1_ch3971 6.294e-121 394.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,3XMX5@561|Escherichia 1236|Gammaproteobacteria M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046872,GO:0071704,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_2206,iSF_1195.SF2102,iSFxv_1172.SFxv_2338,iS_1188.S2225 NTP_transferase YYD3_k127_1386105_4 679200.HMPREF9333_01183 0.0002478 46.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia 186801|Clostridia M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind YYD3_k127_1392448_4 395961.Cyan7425_3504 2.803e-12 71.0 COG2202@1|root,COG3920@1|root,COG2202@2|Bacteria,COG3920@2|Bacteria 2|Bacteria T Histidine kinase pdtaS - 2.7.13.3 ko:K00936,ko:K02030 - M00236,M00839 - - ko00000,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 - - HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9 YYD3_k127_1392448_3 497964.CfE428DRAFT_6306 8.291e-78 276.0 COG1879@1|root,COG1879@2|Bacteria,46W7Q@74201|Verrucomicrobia 74201|Verrucomicrobia G PFAM periplasmic binding protein LacI transcriptional regulator - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 YYD3_k127_1392448_1 313628.LNTAR_12346 4.741e-154 501.0 COG1129@1|root,COG1129@2|Bacteria 2|Bacteria G ABC transporter - - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran YYD3_k127_1392448_2 497964.CfE428DRAFT_6304 3.062e-128 425.0 COG1172@1|root,COG1172@2|Bacteria,46V1Z@74201|Verrucomicrobia 74201|Verrucomicrobia G Belongs to the binding-protein-dependent transport system permease family - - - - - - - - - - - - BPD_transp_2 YYD3_k127_1392448_0 661478.OP10G_0991 5.426e-275 877.0 COG0383@1|root,COG0383@2|Bacteria 2|Bacteria G mannose metabolic process - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,F5_F8_type_C,Glyco_hydro_38,Glyco_hydro_38C YYD3_k127_1392524_2 880073.Calab_2051 1.871e-09 59.0 COG0228@1|root,COG0228@2|Bacteria,2NPWN@2323|unclassified Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 YYD3_k127_1392524_0 880073.Calab_2050 6.802e-158 509.0 COG0541@1|root,COG0541@2|Bacteria,2NNT9@2323|unclassified Bacteria 2|Bacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB YYD3_k127_1392524_1 945713.IALB_2977 9.86e-19 91.0 COG1506@1|root,COG1506@2|Bacteria 2|Bacteria E serine-type peptidase activity dap2 - - - - - - - - - - - PD40,Peptidase_S9 YYD3_k127_1434614_2 1279009.ADICEAN_02760 1.919e-25 111.0 COG2318@1|root,COG2318@2|Bacteria,4NRAP@976|Bacteroidetes,47NZT@768503|Cytophagia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 YYD3_k127_1434614_0 706587.Desti_1549 1.758e-68 240.0 COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,42UXR@68525|delta/epsilon subdivisions,2WQCT@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 YYD3_k127_1434614_1 686340.Metal_1682 7.249e-66 235.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RXW3@1236|Gammaproteobacteria,1XGS8@135618|Methylococcales 135618|Methylococcales E Sodium:solute symporter family - - - - - - - - - - - - SSF YYD3_k127_1445111_0 1519464.HY22_07040 2.022e-193 618.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1FEF9@1090|Chlorobi 1090|Chlorobi C electron transfer flavoprotein-ubiquinone oxidoreductase - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO YYD3_k127_1445111_1 404380.Gbem_3509 2.853e-17 91.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,42QTI@68525|delta/epsilon subdivisions,2WMRH@28221|Deltaproteobacteria,43SYN@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase YYD3_k127_1445111_2 468059.AUHA01000002_gene787 5.207e-10 63.0 2E77J@1|root,331RB@2|Bacteria,4NZES@976|Bacteroidetes,1IUK7@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_1446404_1 1379698.RBG1_1C00001G1788 3.357e-33 132.0 COG2067@1|root,COG3292@1|root,COG2067@2|Bacteria,COG3292@2|Bacteria,2NPQZ@2323|unclassified Bacteria 2|Bacteria I Two component regulator propeller - - - - - - - - - - - - CHB_HEX_C_1,Reg_prop,Reprolysin_5,VCBS YYD3_k127_1446404_0 1379698.RBG1_1C00001G1787 1.692e-127 438.0 COG1520@1|root,COG4412@1|root,COG1520@2|Bacteria,COG4412@2|Bacteria,2NPRE@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - DUF1863,PQQ_2 YYD3_k127_1473368_8 96561.Dole_1704 7.036e-14 85.0 COG3420@1|root,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales 1224|Proteobacteria P Parallel beta-helix repeats - - - - - - - - - - - - - YYD3_k127_1473368_5 1185876.BN8_03007 5.539e-33 141.0 COG0726@1|root,COG0726@2|Bacteria,4NKYS@976|Bacteroidetes,47NF6@768503|Cytophagia 976|Bacteroidetes G PFAM Polysaccharide deacetylase pgdA - - - - - - - - - - - Polysacc_deac_1 YYD3_k127_1473368_1 521098.Aaci_2352 5.619e-104 354.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,4H9VY@91061|Bacilli,2786F@186823|Alicyclobacillaceae 91061|Bacilli G Belongs to the pyruvate kinase family pyk GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C YYD3_k127_1473368_11 63737.Npun_F1211 4.552e-06 54.0 COG0642@1|root,COG0784@1|root,COG2199@1|root,COG3850@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3850@2|Bacteria,1G09B@1117|Cyanobacteria,1HJ6D@1161|Nostocales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - HAMP,HATPase_c,HisKA,Response_reg,dCache_1 YYD3_k127_1473368_9 1122139.KB907865_gene1497 5.411e-09 63.0 COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,1S8N8@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase YYD3_k127_1473368_0 1094980.Mpsy_2456 9.882e-152 492.0 COG0415@1|root,arCOG02840@2157|Archaea,2XTVM@28890|Euryarchaeota,2NAIC@224756|Methanomicrobia 224756|Methanomicrobia L FAD binding domain of DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 YYD3_k127_1473368_3 1379698.RBG1_1C00001G1071 1.491e-53 194.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB_2 YYD3_k127_1473368_2 686340.Metal_3843 5.563e-77 277.0 COG4262@1|root,COG4262@2|Bacteria,1QUK8@1224|Proteobacteria,1T460@1236|Gammaproteobacteria,1XEF0@135618|Methylococcales 135618|Methylococcales S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - YYD3_k127_1473368_6 1267533.KB906735_gene4861 1.816e-23 113.0 COG0265@1|root,COG0265@2|Bacteria,3Y7GN@57723|Acidobacteria,2JM8V@204432|Acidobacteriia 204432|Acidobacteriia O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - - YYD3_k127_1473368_4 408672.NBCG_01888 1.064e-33 143.0 COG0265@1|root,COG0265@2|Bacteria,2ICC4@201174|Actinobacteria 201174|Actinobacteria O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - - YYD3_k127_1473368_7 1121918.ARWE01000001_gene1063 2.549e-16 83.0 2DRTV@1|root,33D1E@2|Bacteria,1NGE0@1224|Proteobacteria,42X1H@68525|delta/epsilon subdivisions,2WT7W@28221|Deltaproteobacteria,43VCT@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF2914) - - - - - - - - - - - - DUF2914 YYD3_k127_1515168_2 1379698.RBG1_1C00001G0447 4.191e-36 142.0 COG3880@1|root,COG3880@2|Bacteria,2NRIE@2323|unclassified Bacteria 2|Bacteria S UvrB/uvrC motif CP_0046 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 ko:K19405,ko:K19411 - - R11090 RC00002,RC00203 ko00000,ko01000 - - - GSu_C4xC__C2xCH,UVR YYD3_k127_1515168_1 861299.J421_3214 7.623e-69 241.0 COG1136@1|root,COG1136@2|Bacteria,1ZSNF@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Part of the ABC transporter complex LolCDE involved in the translocation of lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran YYD3_k127_1515168_0 1379698.RBG1_1C00001G0449 2.151e-100 340.0 COG4591@1|root,COG4591@2|Bacteria,2NP18@2323|unclassified Bacteria 2|Bacteria M ABC-type transport system involved in lipoprotein release permease component lolC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 - - FtsX,MacB_PCD YYD3_k127_1520094_0 1379698.RBG1_1C00001G0659 2.723e-104 342.0 COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran YYD3_k127_1520094_4 1121930.AQXG01000004_gene2868 1.375e-12 80.0 COG1572@1|root,COG2911@1|root,COG4733@1|root,COG1572@2|Bacteria,COG2911@2|Bacteria,COG4733@2|Bacteria,4NYS6@976|Bacteroidetes,1IZ9T@117747|Sphingobacteriia 976|Bacteroidetes S Parallel beta-helix repeats - - - - - - - - - - - - - YYD3_k127_1520094_2 401526.TcarDRAFT_1265 1.468e-33 138.0 298ZI@1|root,2ZW3A@2|Bacteria,1V7FU@1239|Firmicutes,4H5FQ@909932|Negativicutes 909932|Negativicutes S ECF transporter, substrate-specific component - - - - - - - - - - - - ECF_trnsprt YYD3_k127_1520094_3 477974.Daud_1148 1.884e-31 132.0 COG0500@1|root,COG2226@2|Bacteria,1V6EF@1239|Firmicutes,24JZ4@186801|Clostridia,262N8@186807|Peptococcaceae 186801|Clostridia Q PFAM methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 YYD3_k127_1520094_5 1095772.CAHH01000040_gene2417 9.651e-08 59.0 COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria 201174|Actinobacteria OU Membrane protein implicated in regulation of membrane protease activity nfeD - - - - - - - - - - - NfeD YYD3_k127_1520094_1 247490.KSU1_C0202 3.99e-96 324.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflC GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - Band_7 YYD3_k127_1543448_2 1231391.AMZF01000012_gene2675 1.23e-96 318.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria,3T6UR@506|Alcaligenaceae 28216|Betaproteobacteria O C-terminal domain of 1-Cys peroxiredoxin lsfA - - - - - - - - - - - 1-cysPrx_C,AhpC-TSA YYD3_k127_1543448_0 1121104.AQXH01000003_gene311 3.414e-140 460.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,4NE2Y@976|Bacteroidetes,1IUW3@117747|Sphingobacteriia 976|Bacteroidetes P Rhodanese Homology Domain - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B,Rhodanese YYD3_k127_1543448_1 338966.Ppro_2179 9.404e-116 382.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,42P59@68525|delta/epsilon subdivisions,2WJUJ@28221|Deltaproteobacteria,43W2K@69541|Desulfuromonadales 28221|Deltaproteobacteria S Conserved hypothetical protein 698 - - - - - - - - - - - - Cons_hypoth698 YYD3_k127_1565111_0 1379698.RBG1_1C00001G1039 4.901e-184 592.0 COG0317@1|root,COG0317@2|Bacteria,2NNM0@2323|unclassified Bacteria 2|Bacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS YYD3_k127_1565111_1 1379698.RBG1_1C00001G1038 2.272e-56 209.0 COG0859@1|root,COG0859@2|Bacteria,2NPXQ@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 YYD3_k127_156523_2 765420.OSCT_2598 2.404e-20 97.0 COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi,3750X@32061|Chloroflexia 32061|Chloroflexia C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 YYD3_k127_156523_3 795359.TOPB45_0383 8.773e-13 77.0 COG3945@1|root,COG3945@2|Bacteria 2|Bacteria P hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin YYD3_k127_156523_0 926550.CLDAP_26360 8.124e-76 277.0 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2G7I4@200795|Chloroflexi 200795|Chloroflexi UW Hep Hag repeat protein - - - - - - - - - - - - - YYD3_k127_156523_1 316067.Geob_1385 7.988e-36 139.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,42NDS@68525|delta/epsilon subdivisions,2WJDE@28221|Deltaproteobacteria,43V4T@69541|Desulfuromonadales 28221|Deltaproteobacteria S RmuC family - - - ko:K09760 - - - - ko00000 - - - RmuC YYD3_k127_1581712_0 479434.Sthe_1653 1.09e-167 542.0 COG1012@1|root,COG1012@2|Bacteria,2G5NY@200795|Chloroflexi,27XK3@189775|Thermomicrobia 189775|Thermomicrobia C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh YYD3_k127_1581712_1 1379698.RBG1_1C00001G0205 5.541e-94 317.0 COG0648@1|root,COG0648@2|Bacteria,2NNN3@2323|unclassified Bacteria 2|Bacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 YYD3_k127_1581712_3 1304885.AUEY01000038_gene2578 1.936e-32 130.0 COG1832@1|root,COG1832@2|Bacteria,1PUW7@1224|Proteobacteria,42T5D@68525|delta/epsilon subdivisions,2WPHZ@28221|Deltaproteobacteria,2MK69@213118|Desulfobacterales 28221|Deltaproteobacteria S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 YYD3_k127_1581712_2 945713.IALB_0468 1.547e-46 173.0 2BN55@1|root,33HC1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_1604853_4 643867.Ftrac_0693 3.676e-97 332.0 COG1108@1|root,COG1321@1|root,COG1108@2|Bacteria,COG1321@2|Bacteria,4NH3D@976|Bacteroidetes,47MU3@768503|Cytophagia 976|Bacteroidetes KP ABC 3 transport family mntC - - ko:K11708 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ABC-3,Fe_dep_repr_C YYD3_k127_1604853_2 153721.MYP_4042 8.851e-110 359.0 COG1121@1|root,COG1121@2|Bacteria,4NHZ9@976|Bacteroidetes,47KSI@768503|Cytophagia 976|Bacteroidetes P ATPases associated with a variety of cellular activities troB - 3.6.3.35 ko:K11710,ko:K19973 ko02010,map02010 M00319,M00792 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.15.15 - - ABC_tran YYD3_k127_1604853_3 649747.HMPREF0083_00441 4.571e-105 349.0 COG0803@1|root,COG0803@2|Bacteria,1TRKU@1239|Firmicutes,4HAKT@91061|Bacilli,26R1W@186822|Paenibacillaceae 91061|Bacilli P Belongs to the bacterial solute-binding protein 9 family troA - - ko:K11707 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ZnuA YYD3_k127_1604853_10 69014.TK0107 3.739e-19 93.0 COG1321@1|root,arCOG02100@2157|Archaea,2XZV0@28890|Euryarchaeota,245GN@183968|Thermococci 183968|Thermococci K Helix-turn-helix diphteria tox regulatory element - - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress YYD3_k127_1604853_6 1382304.JNIL01000001_gene1095 5.972e-90 310.0 COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,4H9WQ@91061|Bacilli,278YX@186823|Alicyclobacillaceae 91061|Bacilli E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 YYD3_k127_1604853_7 1379698.RBG1_1C00001G0220 4.024e-54 211.0 COG3292@1|root,COG3292@2|Bacteria,2NR5N@2323|unclassified Bacteria 2|Bacteria T Two component regulator propeller - - - ko:K19693 - - - - ko00000,ko03000 - - - HATPase_c,HTH_18,HisKA,Response_reg YYD3_k127_1604853_11 177439.DP1640 8.368e-06 57.0 COG4856@1|root,COG4856@2|Bacteria,1REEU@1224|Proteobacteria,42RY2@68525|delta/epsilon subdivisions,2WNZH@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM YbbR family protein - - - - - - - - - - - - YbbR YYD3_k127_1604853_1 1379698.RBG1_1C00001G0218 1.107e-115 381.0 COG0533@1|root,COG0533@2|Bacteria,2NNXP@2323|unclassified Bacteria 2|Bacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Peptidase_M22 YYD3_k127_1604853_0 880073.Calab_2282 2.217e-170 565.0 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2NNKI@2323|unclassified Bacteria 2|Bacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - DUF2344,Radical_SAM YYD3_k127_1604853_5 1379698.RBG1_1C00001G0941 1.565e-96 333.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2NP36@2323|unclassified Bacteria 2|Bacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB YYD3_k127_1604853_9 574087.Acear_1434 1.383e-24 113.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WAHY@53433|Halanaerobiales 186801|Clostridia T Protein kinase domain prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase YYD3_k127_1604853_12 1122134.KB893650_gene53 6.991e-05 54.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XJPG@135619|Oceanospirillales 135619|Oceanospirillales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR YYD3_k127_1604853_8 518766.Rmar_0288 1.277e-38 157.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,4NI98@976|Bacteroidetes 976|Bacteroidetes KT Serine phosphatase RsbU regulator of sigma subunit - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE YYD3_k127_1613753_0 1121904.ARBP01000006_gene4059 8.571e-165 531.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,47N7Y@768503|Cytophagia 976|Bacteroidetes QU Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,PD40 YYD3_k127_1613753_1 1279017.AQYJ01000028_gene2405 1.187e-159 522.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,466B9@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 YYD3_k127_1613753_2 593117.TGAM_1466 1.934e-06 62.0 arCOG03256@1|root,arCOG07561@1|root,arCOG03256@2157|Archaea,arCOG07561@2157|Archaea,2Y6BA@28890|Euryarchaeota,243U4@183968|Thermococci 183968|Thermococci K membrane-associated protein domain - - - - - - - - - - - - - YYD3_k127_163129_0 1379698.RBG1_1C00001G0991 1.356e-26 124.0 COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria 2|Bacteria Q FlgD Ig-like domain - - 3.2.1.136 ko:K15924 - - - - ko00000,ko01000 - GH5 - CBM_3,DUF1735,Laminin_G_3 YYD3_k127_163129_1 401053.AciPR4_3151 3.163e-13 83.0 COG3595@1|root,COG3595@2|Bacteria,3Y3K3@57723|Acidobacteria,2JHKF@204432|Acidobacteriia 204432|Acidobacteriia C Putative adhesin - - - - - - - - - - - - DUF4097 YYD3_k127_1643857_2 273068.TTE0836 7.165e-72 256.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42F9E@68295|Thermoanaerobacterales 186801|Clostridia V ABC transporter, transmembrane region - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran YYD3_k127_1643857_5 1234664.AMRO01000048_gene861 6.145e-05 56.0 COG2120@1|root,COG2120@2|Bacteria,1UYPV@1239|Firmicutes,4HCT3@91061|Bacilli 91061|Bacilli M NPCBM-associated, NEW3 domain of alpha-galactosidase - - - - - - - - - - - - NPCBM_assoc,PIG-L YYD3_k127_1643857_4 118166.JH976537_gene3154 2.829e-34 134.0 COG0662@1|root,COG0662@2|Bacteria,1G5PK@1117|Cyanobacteria,1HC1C@1150|Oscillatoriales 1117|Cyanobacteria G PFAM Cupin - - - - - - - - - - - - Cupin_2 YYD3_k127_1643857_1 1379698.RBG1_1C00001G1822 1.308e-80 277.0 COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria 2|Bacteria C Electron transfer flavoprotein etfB GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 - ko:K03521 - - - - ko00000 - - - ETF YYD3_k127_1643857_3 1379698.RBG1_1C00001G1823 2.467e-68 239.0 COG0571@1|root,COG0571@2|Bacteria,2NPCJ@2323|unclassified Bacteria 2|Bacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm YYD3_k127_1643857_0 1379698.RBG1_1C00001G1824 5.237e-124 402.0 COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179,2.3.1.41 ko:K00647,ko:K09458,ko:K14660 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iSB619.SA_RS04785 Ketoacyl-synt_C,ketoacyl-synt YYD3_k127_1657318_4 880073.Calab_3548 1.684e-64 223.0 COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria 2|Bacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 YYD3_k127_1657318_0 1379698.RBG1_1C00001G1160 5.564e-100 334.0 COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria 2|Bacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 YYD3_k127_1657318_6 1499967.BAYZ01000080_gene915 1.459e-31 125.0 COG0184@1|root,COG0184@2|Bacteria,2NPTZ@2323|unclassified Bacteria 2|Bacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 YYD3_k127_1657318_2 1379698.RBG1_1C00001G1158 9.803e-66 235.0 COG0196@1|root,COG0196@2|Bacteria,2NPCV@2323|unclassified Bacteria 2|Bacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K07011,ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase YYD3_k127_1657318_5 1382306.JNIM01000001_gene2748 2.142e-57 211.0 COG0130@1|root,COG0130@2|Bacteria,2G6F4@200795|Chloroflexi 200795|Chloroflexi J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C,TruB_C_2,TruB_N YYD3_k127_1657318_3 1379698.RBG1_1C00001G1156 8.375e-65 237.0 COG0618@1|root,COG0618@2|Bacteria,2NPK0@2323|unclassified Bacteria 2|Bacteria S DHH family nrnA GO:0008150,GO:0040007 2.7.7.72,3.1.13.3,3.1.3.7 ko:K00974,ko:K06881 ko00920,ko01100,ko01120,ko03013,map00920,map01100,map01120,map03013 - R00188,R00508,R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03400 - - - DHH,DHHA1 YYD3_k127_1657318_7 717605.Theco_2056 8.44e-21 98.0 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,4HII1@91061|Bacilli,26YF0@186822|Paenibacillaceae 91061|Bacilli J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA YYD3_k127_1657318_1 518766.Rmar_1309 6.196e-84 282.0 COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,1FIVX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N YYD3_k127_1660099_2 397287.C807_03104 2.619e-33 130.0 COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,27JMT@186928|unclassified Lachnospiraceae 186801|Clostridia M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race YYD3_k127_1660099_0 1379698.RBG1_1C00001G0723 7.617e-83 295.0 COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria 2|Bacteria M Ami_3 amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3 YYD3_k127_1660099_1 880073.Calab_1982 4.848e-47 174.0 COG0691@1|root,COG0691@2|Bacteria,2NPFK@2323|unclassified Bacteria 2|Bacteria O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 - ko:K03664 - - - - ko00000 - - - SmpB YYD3_k127_1660099_3 1313421.JHBV01000029_gene1863 3.855e-09 59.0 COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,1IPM8@117747|Sphingobacteriia 976|Bacteroidetes T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C YYD3_k127_1720926_3 1123267.JONN01000001_gene1238 1.502e-68 243.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP YYD3_k127_1720926_5 1303518.CCALI_01897 1.454e-32 135.0 COG1595@1|root,COG1595@2|Bacteria 1303518.CCALI_01897|- K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - - YYD3_k127_1720926_7 926549.KI421517_gene3870 4.499e-09 61.0 COG1366@1|root,COG1366@2|Bacteria,4PC5I@976|Bacteroidetes,47WUM@768503|Cytophagia 976|Bacteroidetes T STAS domain - - - - - - - - - - - - STAS YYD3_k127_1720926_6 1168059.KB899087_gene851 1.097e-14 79.0 COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,2UCGB@28211|Alphaproteobacteria,3F07N@335928|Xanthobacteraceae 28211|Alphaproteobacteria T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2 YYD3_k127_1720926_2 240015.ACP_0686 2.323e-128 421.0 COG0505@1|root,COG0505@2|Bacteria,3Y31Y@57723|Acidobacteria,2JIB8@204432|Acidobacteriia 204432|Acidobacteriia F TIGRFAM Carbamoyl-phosphate synthase, small subunit carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase YYD3_k127_1720926_0 1267535.KB906767_gene717 0.0 1329.0 COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria,2JIJZ@204432|Acidobacteriia 204432|Acidobacteriia F TIGRFAM carbamoyl-phosphate synthase, large subunit carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS YYD3_k127_1720926_1 596152.DesU5LDRAFT_3428 5.493e-141 457.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,42N6F@68525|delta/epsilon subdivisions,2WKX7@28221|Deltaproteobacteria,2M8S4@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM 2-nitropropane dioxygenase NPD - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO YYD3_k127_1720926_4 1379698.RBG1_1C00001G1680 3.346e-52 188.0 COG0513@1|root,COG0513@2|Bacteria,2NP0A@2323|unclassified Bacteria 2|Bacteria JKL Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C YYD3_k127_1727918_3 574087.Acear_0676 4.004e-75 264.0 COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,3WAEZ@53433|Halanaerobiales 186801|Clostridia S PFAM OPT oligopeptide transporter protein - - - - - - - - - - - - OPT YYD3_k127_1727918_2 1379698.RBG1_1C00001G1343 1.085e-81 284.0 COG2199@1|root,COG2199@2|Bacteria,2NS3Z@2323|unclassified Bacteria 2|Bacteria T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF,HAMP YYD3_k127_1727918_4 443143.GM18_1697 1.422e-69 246.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,43TES@69541|Desulfuromonadales 28221|Deltaproteobacteria D integrase domain protein SAM domain protein xerD - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase YYD3_k127_1727918_7 1235800.C819_03197 1.869e-27 121.0 COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,27MSJ@186928|unclassified Lachnospiraceae 186801|Clostridia S ComF family comF - - ko:K02242 - M00429 - - ko00000,ko00002,ko02044 - - - Pribosyltran YYD3_k127_1727918_10 945713.IALB_2217 9.461e-14 80.0 COG0457@1|root,COG0457@2|Bacteria 945713.IALB_2217|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - YYD3_k127_1727918_1 945713.IALB_1883 5.125e-103 356.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 YYD3_k127_1727918_0 1121920.AUAU01000004_gene672 4.089e-106 355.0 COG3342@1|root,COG3342@2|Bacteria,3Y80E@57723|Acidobacteria 57723|Acidobacteria S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028 YYD3_k127_1727918_6 880073.Calab_0082 1.584e-29 125.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD3_k127_1727918_5 1480694.DC28_03280 7.944e-36 138.0 COG0393@1|root,COG0393@2|Bacteria 2|Bacteria S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 YYD3_k127_1727918_9 1301098.PKB_1895 1.45e-16 91.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RYKY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily - - - - - - - - - - - - Sulfatase YYD3_k127_1727918_11 663610.JQKO01000005_gene2376 5.198e-10 60.0 COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,2TR9F@28211|Alphaproteobacteria,3N9WT@45404|Beijerinckiaceae 28211|Alphaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glyco_trans_2_3 YYD3_k127_1735085_0 1379698.RBG1_1C00001G0223 8.361e-75 260.0 COG0284@1|root,COG0284@2|Bacteria,2NP92@2323|unclassified Bacteria 2|Bacteria F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 ko:K01591,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS17585 OMPdecase YYD3_k127_1735085_1 661478.OP10G_0354 1.364e-59 213.0 COG4312@1|root,COG4312@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF899) - - - - - - - - - - - - DUF899 YYD3_k127_1735085_3 1341181.FLJC2902T_14440 5.573e-38 145.0 COG3631@1|root,COG3631@2|Bacteria,4NTMZ@976|Bacteroidetes,1I61G@117743|Flavobacteriia,2NWYB@237|Flavobacterium 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 YYD3_k127_1735085_2 583355.Caka_0865 6.683e-39 149.0 COG1032@1|root,COG1032@2|Bacteria,46V7P@74201|Verrucomicrobia,3K74V@414999|Opitutae 414999|Opitutae C Domain of unknown function (DUF4070) - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM YYD3_k127_176289_0 338966.Ppro_3003 6.917e-148 481.0 COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria,43T88@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Xanthine uracil vitamin C permease pbuG - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease YYD3_k127_176289_1 215803.DB30_2841 1.169e-144 472.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions,2WJ6Q@28221|Deltaproteobacteria,2YWF8@29|Myxococcales 28221|Deltaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 YYD3_k127_176289_2 1379698.RBG1_1C00001G1677 2.003e-113 375.0 COG3239@1|root,COG3239@2|Bacteria,2NNTZ@2323|unclassified Bacteria 2|Bacteria I Fatty acid desaturase des - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase YYD3_k127_176289_3 1049564.TevJSym_ad00590 3.212e-55 199.0 COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,1RPV0@1236|Gammaproteobacteria,1J68H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MarC family integral membrane protein yhgN GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC YYD3_k127_1779448_0 1379698.RBG1_1C00001G1225 1.598e-230 728.0 COG0539@1|root,COG0539@2|Bacteria,2NNTP@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein S1 rpsA GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010 1.17.7.4,2.7.11.1 ko:K02945,ko:K03527,ko:K12132 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko01001,ko03011 - - - S1 YYD3_k127_1779448_3 1379698.RBG1_1C00001G1226 4.36e-45 171.0 COG0204@1|root,COG0204@2|Bacteria,2NPW3@2323|unclassified Bacteria 2|Bacteria I Phosphate acyltransferases cmk - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase YYD3_k127_1779448_2 1218173.BALCAV_0200475 2.292e-56 204.0 COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,4HFZE@91061|Bacilli,1ZBXZ@1386|Bacillus 91061|Bacilli F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin YYD3_k127_1779448_1 1121468.AUBR01000005_gene92 1.273e-57 209.0 COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,25C2V@186801|Clostridia,42J43@68295|Thermoanaerobacterales 186801|Clostridia ET Ligated ion channel L-glutamate- and glycine-binding site glnH - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 YYD3_k127_1779448_4 1346330.M472_19465 0.0008956 50.0 2AX7X@1|root,31P6Q@2|Bacteria,4NGGX@976|Bacteroidetes,1ISH8@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_1798490_0 880073.Calab_0988 1.247e-100 346.0 COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,2NPAA@2323|unclassified Bacteria 2|Bacteria S AMMECR1 - - - ko:K06990,ko:K09141 - - - - ko00000,ko04812 - - - AMMECR1,Memo YYD3_k127_1798490_1 745411.B3C1_04510 1.329e-17 87.0 COG5033@1|root,COG5033@2|Bacteria,1NBJM@1224|Proteobacteria,1SGE8@1236|Gammaproteobacteria 1236|Gammaproteobacteria K YEATS family - - - - - - - - - - - - YEATS YYD3_k127_1798490_2 765869.BDW_00590 1.454e-11 68.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2MUQI@213481|Bdellovibrionales,2WM7E@28221|Deltaproteobacteria 213481|Bdellovibrionales M PFAM NAD-dependent epimerase dehydratase dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - 3Beta_HSD,Epimerase YYD3_k127_1800023_3 316067.Geob_1620 1.886e-07 55.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - ko:K16191,ko:K20276 ko02024,map02024 - - - ko00000,ko00001,ko02000 1.B.6.1.3 - - Big_3_2,Calx-beta,OmpA YYD3_k127_1800023_2 1379698.RBG1_1C00001G1104 2.614e-09 65.0 2B0A3@1|root,31SM2@2|Bacteria,2NRWJ@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 YYD3_k127_1800023_4 243231.GSU2713 5.458e-06 52.0 2CG1Y@1|root,32WID@2|Bacteria,1N01A@1224|Proteobacteria,42UK0@68525|delta/epsilon subdivisions,2WQED@28221|Deltaproteobacteria,43SMQ@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573,PapD-like YYD3_k127_1800023_1 1379698.RBG1_1C00001G1104 5.164e-12 75.0 2B0A3@1|root,31SM2@2|Bacteria,2NRWJ@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 YYD3_k127_1800023_0 530564.Psta_0816 2.381e-28 119.0 COG1131@1|root,COG1131@2|Bacteria,2IZ31@203682|Planctomycetes 203682|Planctomycetes V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD3_k127_1815043_3 1379698.RBG1_1C00001G0223 7.049e-25 106.0 COG0284@1|root,COG0284@2|Bacteria,2NP92@2323|unclassified Bacteria 2|Bacteria F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 ko:K01591,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS17585 OMPdecase YYD3_k127_1815043_0 868864.Dester_1492 8.996e-88 299.0 COG0167@1|root,COG0167@2|Bacteria,2G3JU@200783|Aquificae 200783|Aquificae F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh YYD3_k127_1815043_1 643648.Slip_0840 1.233e-50 189.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,42K0H@68298|Syntrophomonadaceae 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 YYD3_k127_1815043_2 1379698.RBG1_1C00001G0226 7.441e-32 142.0 COG1729@1|root,COG1729@2|Bacteria,2NPUR@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 YYD3_k127_184633_2 1379698.RBG1_1C00001G0129 7.789e-22 98.0 COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria 2|Bacteria S Bifunctional nuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K03617,ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR YYD3_k127_184633_0 1216932.CM240_0088 4.267e-31 141.0 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,36DTA@31979|Clostridiaceae 186801|Clostridia E PFAM Extracellular ligand-binding receptor braC - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 YYD3_k127_184633_1 1379698.RBG1_1C00001G0126 8.829e-25 110.0 2C451@1|root,2ZRAU@2|Bacteria,2NS2X@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_184633_4 1379698.RBG1_1C00001G0125 1.257e-21 101.0 2EGJW@1|root,3110Q@2|Bacteria,2NS2A@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_184633_6 1038860.AXAP01000083_gene433 4.643e-09 66.0 COG0457@1|root,COG0457@2|Bacteria,1N6TJ@1224|Proteobacteria,2UG5W@28211|Alphaproteobacteria,3JZ4G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_8 YYD3_k127_184633_3 1379698.RBG1_1C00001G0980 9.978e-22 105.0 COG1862@1|root,COG1862@2|Bacteria,2NPY3@2323|unclassified Bacteria 2|Bacteria U Preprotein translocase, YajC yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC YYD3_k127_1854305_2 443144.GM21_3584 4.982e-13 77.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42P32@68525|delta/epsilon subdivisions,2WM9Q@28221|Deltaproteobacteria,43URZ@69541|Desulfuromonadales 28221|Deltaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6 YYD3_k127_1854305_0 398767.Glov_3469 2.648e-37 146.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,43UVU@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM OmpA MotB domain protein pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA YYD3_k127_1854305_1 551789.ATVJ01000001_gene850 6.231e-14 74.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,43WKN@69657|Hyphomonadaceae 28211|Alphaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N YYD3_k127_1880560_0 1379698.RBG1_1C00001G0356 2.493e-90 328.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,2NS3S@2323|unclassified Bacteria 2|Bacteria EG Protein of unknown function (DUF2723) - - - ko:K16928 - M00582 - - ko00000,ko00002,ko02000 3.A.1.33 - - DUF2723,QueT YYD3_k127_1880560_1 1379698.RBG1_1C00001G1319 7.742e-08 54.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 YYD3_k127_1906186_6 1379698.RBG1_1C00001G0830 1.483e-55 199.0 COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria 2|Bacteria J elongation factor G fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 YYD3_k127_1906186_16 667014.Thein_1798 5.089e-07 61.0 28WYN@1|root,2ZIXP@2|Bacteria,2GIB8@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 YYD3_k127_1906186_13 635013.TherJR_1422 8.455e-11 73.0 COG3391@1|root,COG3391@2|Bacteria,1V2KS@1239|Firmicutes,24FSD@186801|Clostridia 186801|Clostridia S PFAM NHL repeat containing protein - - - - - - - - - - - - NHL YYD3_k127_1906186_12 316067.Geob_3162 6.883e-13 76.0 2EUMZ@1|root,33N3U@2|Bacteria,1NUNW@1224|Proteobacteria,42ZFD@68525|delta/epsilon subdivisions,2WV00@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_1906186_10 316067.Geob_3163 1.962e-15 84.0 COG4380@1|root,COG4380@2|Bacteria,1NJYS@1224|Proteobacteria,42X1E@68525|delta/epsilon subdivisions,2WTEE@28221|Deltaproteobacteria,43VPV@69541|Desulfuromonadales 28221|Deltaproteobacteria S Putative bacterial lipoprotein (DUF799) - - - - - - - - - - - - DUF799 YYD3_k127_1906186_11 635013.TherJR_2221 4.34e-15 87.0 COG4409@1|root,COG4733@1|root,COG4409@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - - - - - - - - - - ASH,BNR_2,CBM_35,DUF1080,F5_F8_type_C,PKD YYD3_k127_1906186_14 404380.Gbem_1116 1.252e-08 66.0 28WYN@1|root,33TG0@2|Bacteria,1NTYC@1224|Proteobacteria,42YTU@68525|delta/epsilon subdivisions,2WU4Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 6 heme-binding sites - - - - - - - - - - - - - YYD3_k127_1906186_17 1125699.HMPREF9194_00454 1.913e-06 59.0 COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes 203691|Spirochaetes S NHL repeat containing protein - - - - - - - - - - - - NHL,TPR_11 YYD3_k127_1906186_1 1121920.AUAU01000024_gene2388 4.122e-173 582.0 COG3005@1|root,COG3043@1|root,COG3005@2|Bacteria,COG3043@2|Bacteria,3Y4BJ@57723|Acidobacteria 57723|Acidobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 YYD3_k127_1906186_15 1125863.JAFN01000001_gene275 1.274e-07 62.0 COG3005@1|root,COG3005@2|Bacteria,1NFFE@1224|Proteobacteria,430BS@68525|delta/epsilon subdivisions,2WVRX@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Doubled CXXCH motif (Paired_CXXCH_1) - - - - - - - - - - - - Paired_CXXCH_1 YYD3_k127_1906186_5 986075.CathTA2_0103 4.823e-72 249.0 COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,4HDUN@91061|Bacilli 91061|Bacilli S Belongs to the SOS response-associated peptidase family yoqW - - - - - - - - - - - SRAP YYD3_k127_1906186_0 518766.Rmar_0902 0.0 1341.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1FJ61@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_4 - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran YYD3_k127_1906186_4 1519464.HY22_01410 5.291e-85 293.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 YYD3_k127_1906186_9 1117647.M5M_06390 9.257e-19 98.0 29QWA@1|root,30BWM@2|Bacteria,1REIR@1224|Proteobacteria,1S50N@1236|Gammaproteobacteria,1J7C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - CBM_11,VanZ YYD3_k127_1906186_3 1379698.RBG1_1C00001G0711 1.728e-137 452.0 COG0612@1|root,COG0612@2|Bacteria,2NQHV@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) ymxG - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C YYD3_k127_1906186_2 1379698.RBG1_1C00001G0712 1.096e-159 518.0 COG0612@1|root,COG0612@2|Bacteria,2NQPM@2323|unclassified Bacteria 2|Bacteria S Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C YYD3_k127_1906186_7 509191.AEDB02000022_gene2925 7.422e-45 180.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,3WIT1@541000|Ruminococcaceae 186801|Clostridia O Subtilase family - - - ko:K13274,ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Big_2,Peptidase_S8,SLH YYD3_k127_1906186_8 504728.K649_03590 5.874e-41 175.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria 2|Bacteria S CHAT domain - - - - - - - - - - - - CHAT,Haemagg_act,TPR_10,TPR_12,TPR_7,TPR_8 YYD3_k127_1917545_2 693986.MOC_1010 1.498e-38 150.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2U249@28211|Alphaproteobacteria,1JUUW@119045|Methylobacteriaceae 28211|Alphaproteobacteria O peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N,Rhodanese YYD3_k127_1917545_1 1379698.RBG1_1C00001G1697 1.773e-127 419.0 COG0626@1|root,COG0626@2|Bacteria,2NNNS@2323|unclassified Bacteria 2|Bacteria E Cys/Met metabolism PLP-dependent enzyme metC GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 ko:K01739,ko:K01758,ko:K01760,ko:K01761 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP YYD3_k127_1917545_0 1379698.RBG1_1C00001G1698 7.554e-130 422.0 COG0031@1|root,COG0031@2|Bacteria,2NP1M@2323|unclassified Bacteria 2|Bacteria E Pyridoxal-phosphate dependent enzyme cysK - 2.5.1.47,4.2.1.22 ko:K01697,ko:K01738 ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00035,M00338 R00891,R00897,R01290,R03601,R04859,R04942 RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP YYD3_k127_1917545_3 313594.PI23P_01857 9.827e-32 129.0 COG0782@1|root,COG0782@2|Bacteria,4NNH6@976|Bacteroidetes,1I18I@117743|Flavobacteriia,3VW7V@52959|Polaribacter 976|Bacteroidetes K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N YYD3_k127_1917545_4 204669.Acid345_4424 1.68e-05 47.0 COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JIT2@204432|Acidobacteriia 204432|Acidobacteriia F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C YYD3_k127_1930464_0 1379698.RBG1_1C00001G0417 2.738e-95 333.0 COG1198@1|root,COG1198@2|Bacteria,2NNQ3@2323|unclassified Bacteria 2|Bacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII YYD3_k127_1930464_2 582744.Msip34_0836 5.595e-05 55.0 COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VJNV@28216|Betaproteobacteria 28216|Betaproteobacteria M Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_16,TPR_2,TPR_8 YYD3_k127_1930464_1 247490.KSU1_B0213 2.586e-45 169.0 COG5316@1|root,COG5316@2|Bacteria,2J1YD@203682|Planctomycetes 203682|Planctomycetes S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 YYD3_k127_1942016_0 1136177.KCA1_1248 5.32e-142 461.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,3F3UP@33958|Lactobacillaceae 91061|Bacilli E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 YYD3_k127_1942016_10 525378.HMPREF0793_1505 4.01e-38 149.0 COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,4GXNX@90964|Staphylococcaceae 91061|Bacilli C NifU homolog involved in Fe-S cluster formation nifU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - ko:K04488 - - - - ko00000 - - - NifU_N YYD3_k127_1942016_11 754477.Q7C_272 2.278e-25 108.0 COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S8YV@1236|Gammaproteobacteria,463JX@72273|Thiotrichales 72273|Thiotrichales S PaaD-like protein - - - - - - - - - - - - FeS_assembly_P YYD3_k127_1942016_5 1379698.RBG1_1C00001G1665 2.426e-110 369.0 COG0845@1|root,COG0845@2|Bacteria,2NQ2U@2323|unclassified Bacteria 2|Bacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion acrA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 YYD3_k127_1942016_7 1379698.RBG1_1C00001G1666 1.904e-103 340.0 COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria 2|Bacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD3_k127_1942016_3 1379698.RBG1_1C00001G1667 2.237e-123 406.0 COG0577@1|root,COG0577@2|Bacteria,2NQPT@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD3_k127_1942016_1 243231.GSU1164 3.623e-125 411.0 COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,42NT4@68525|delta/epsilon subdivisions,2WJFM@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD3_k127_1942016_6 1196323.ALKF01000149_gene1456 2.528e-107 366.0 COG1277@1|root,COG1277@2|Bacteria,1UP3Z@1239|Firmicutes,4IUZZ@91061|Bacilli,276YX@186822|Paenibacillaceae 2|Bacteria S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - - YYD3_k127_1942016_4 304371.MCP_1300 7.348e-123 400.0 COG1131@1|root,arCOG00194@2157|Archaea,2XVFB@28890|Euryarchaeota,2NARP@224756|Methanomicrobia 224756|Methanomicrobia E ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran YYD3_k127_1942016_2 215803.DB30_5113 1.43e-124 417.0 COG0793@1|root,COG0793@2|Bacteria,1RGID@1224|Proteobacteria,4382G@68525|delta/epsilon subdivisions,2X3CI@28221|Deltaproteobacteria,2YVET@29|Myxococcales 28221|Deltaproteobacteria M tail specific protease - - - - - - - - - - - - Peptidase_S41 YYD3_k127_1942016_9 313606.M23134_01115 4.819e-71 252.0 COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,4NHRI@976|Bacteroidetes,47KP6@768503|Cytophagia 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 YYD3_k127_1942016_8 204669.Acid345_4043 1.149e-90 313.0 COG1680@1|root,COG1680@2|Bacteria,3Y7SG@57723|Acidobacteria,2JMWV@204432|Acidobacteriia 204432|Acidobacteriia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase YYD3_k127_1942149_0 313606.M23134_07077 4.551e-09 68.0 COG5002@1|root,COG5002@2|Bacteria,4PKBV@976|Bacteroidetes,47MII@768503|Cytophagia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA YYD3_k127_1942149_1 314607.KB13_1086 3.297e-05 55.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1KQED@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD3_k127_1942149_2 1219080.VEZ01S_11_00180 5.064e-05 49.0 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1XUBY@135623|Vibrionales 135623|Vibrionales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 YYD3_k127_1956344_0 1288963.ADIS_1789 4.231e-07 63.0 2C5G3@1|root,2Z8TT@2|Bacteria,4P166@976|Bacteroidetes,47TW0@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_1963020_1 289376.THEYE_A0321 2.39e-27 120.0 COG1625@1|root,COG1625@2|Bacteria,3J0XK@40117|Nitrospirae 40117|Nitrospirae C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512 YYD3_k127_1963020_0 645991.Sgly_1695 2.848e-127 421.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,2602V@186807|Peptococcaceae 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 YYD3_k127_1963020_2 1307761.L21SP2_1785 1.002e-06 59.0 COG3829@1|root,COG3829@2|Bacteria,2J63K@203691|Spirochaetes 203691|Spirochaetes KT Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat YYD3_k127_1969961_0 1379698.RBG1_1C00001G1445 1.406e-150 495.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NQSG@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - BSP,Bac_surface_Ag,PD40,Peptidase_MA_2 YYD3_k127_1969961_2 479434.Sthe_1246 1.544e-26 123.0 COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2G5NM@200795|Chloroflexi,27Z13@189775|Thermomicrobia 189775|Thermomicrobia KLT PQQ-like domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PQQ_3,Pkinase YYD3_k127_1969961_1 1379698.RBG1_1C00001G1443 1.073e-51 207.0 COG1413@1|root,COG1413@2|Bacteria 2|Bacteria C deoxyhypusine monooxygenase activity - - 3.4.24.3 ko:K01387 - - - - ko00000,ko01000,ko01002,ko02042 - - - DUF4132,DUF4145,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Pro_isomerase YYD3_k127_1969961_3 688269.Theth_0014 2.849e-20 96.0 COG0071@1|root,COG0071@2|Bacteria,2GDCG@200918|Thermotogae 200918|Thermotogae O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 YYD3_k127_1971455_2 1379698.RBG1_1C00001G0016 2.75e-43 169.0 COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria 2|Bacteria T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_1971455_0 945713.IALB_1148 6.488e-231 721.0 COG2079@1|root,COG2079@2|Bacteria 2|Bacteria S 2-methylcitrate dehydratase activity prpD GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD YYD3_k127_1971455_1 880073.Calab_1833 2.188e-141 456.0 COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,2NNYT@2323|unclassified Bacteria 2|Bacteria E Aconitase family (aconitate hydratase) leuD - 4.2.1.33,4.2.1.35,4.2.1.36 ko:K01703,ko:K01704,ko:K01705 ko00290,ko00300,ko00660,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00966,map01100,map01110,map01120,map01130,map01210,map01230 M00030,M00432,M00433,M00535 R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C YYD3_k127_1989509_0 945713.IALB_1079 3.222e-244 765.0 COG1866@1|root,COG1866@2|Bacteria 2|Bacteria H phosphoenolpyruvate carboxykinase (ATP) activity pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP YYD3_k127_1989509_2 945713.IALB_1080 5.118e-155 499.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_1989509_4 373903.Hore_10200 7.072e-103 345.0 COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,3WABQ@53433|Halanaerobiales 186801|Clostridia C PFAM Phosphate acetyl butaryl transferase pta GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB YYD3_k127_1989509_3 880073.Calab_1379 9.071e-134 435.0 COG1186@1|root,COG1186@2|Bacteria,2NNU3@2323|unclassified Bacteria 2|Bacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 YYD3_k127_1989509_5 1379698.RBG1_1C00001G1027 1.906e-59 213.0 COG0491@1|root,COG0491@2|Bacteria,2NPD5@2323|unclassified Bacteria 2|Bacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B YYD3_k127_1989509_8 635013.TherJR_1575 6.245e-43 168.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,26325@186807|Peptococcaceae 186801|Clostridia E histidinol phosphate phosphatase - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP YYD3_k127_1989509_6 351160.RCIX1098 5.37e-52 190.0 COG2094@1|root,arCOG04295@2157|Archaea,2Y0AE@28890|Euryarchaeota,2NB07@224756|Methanomicrobia 224756|Methanomicrobia L alkylbase DNA N-glycosylase activity mpg - 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco YYD3_k127_1989509_7 247490.KSU1_B0618 1.617e-48 180.0 COG1994@1|root,COG1994@2|Bacteria 2|Bacteria S metallopeptidase activity MA20_27160 - - ko:K06402 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M50 YYD3_k127_1989509_1 945713.IALB_0362 3.977e-167 545.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter msbA - - ko:K02021,ko:K06147,ko:K06148,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran YYD3_k127_1989509_9 517418.Ctha_2478 3.531e-20 94.0 COG0438@1|root,COG0438@2|Bacteria,1FD90@1090|Chlorobi 1090|Chlorobi H PFAM glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 YYD3_k127_2007845_3 1379698.RBG1_1C00001G1051 1.6e-76 260.0 COG0377@1|root,COG0377@2|Bacteria,2NP84@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 YYD3_k127_2007845_5 1379698.RBG1_1C00001G1052 2.158e-37 146.0 COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa YYD3_k127_2007845_1 1379698.RBG1_1C00001G1053 9.409e-166 529.0 COG0649@1|root,COG0649@2|Bacteria,2NNWG@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa YYD3_k127_2007845_4 1379698.RBG1_1C00001G1054 2.095e-47 174.0 COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria 2|Bacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.6.5.3 ko:K00334,ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx YYD3_k127_2007845_0 1379698.RBG1_1C00001G1055 2.509e-168 539.0 COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB YYD3_k127_2007845_2 1379698.RBG1_1C00001G1056 6.275e-158 525.0 COG3383@1|root,COG3383@2|Bacteria,2NNQ6@2323|unclassified Bacteria 2|Bacteria C Molydopterin dinucleotide binding domain hcnA - 1.17.1.9,1.4.99.5,1.5.3.1 ko:K00123,ko:K00302,ko:K10814 ko00260,ko00460,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,map00260,map00460,map00630,map00680,map01100,map01110,map01120,map01200 - R00374,R00519,R00610,R05704 RC00060,RC00557,RC02796,RC02808 ko00000,ko00001,ko01000,ko02042 - - - Fer2_4 YYD3_k127_201468_6 237368.SCABRO_01576 1.575e-11 70.0 COG1207@1|root,COG1207@2|Bacteria 2|Bacteria M glucosamine-1-phosphate N-acetyltransferase activity glmU - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_4 YYD3_k127_201468_3 118173.KB235914_gene3815 2.33e-32 133.0 COG0693@1|root,COG0693@2|Bacteria,1G2VP@1117|Cyanobacteria,1H8JH@1150|Oscillatoriales 1117|Cyanobacteria S PFAM DJ-1 PfpI family - - 3.5.1.124 ko:K03152,ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI,DUF2383 YYD3_k127_201468_8 1382359.JIAL01000001_gene1945 4.737e-06 57.0 COG4319@1|root,COG4319@2|Bacteria,3Y4YW@57723|Acidobacteria,2JJHI@204432|Acidobacteriia 204432|Acidobacteriia S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 YYD3_k127_201468_7 1121381.JNIV01000106_gene1932 4.637e-07 59.0 COG2318@1|root,COG2318@2|Bacteria,1WMWY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Protein of unknown function (DUF664) - - - - - - - - - - - - DUF664 YYD3_k127_201468_5 1121897.AUGO01000017_gene1098 4.834e-17 87.0 COG2350@1|root,COG2350@2|Bacteria,4NR5W@976|Bacteroidetes,1I5PD@117743|Flavobacteriia,2NU9F@237|Flavobacterium 976|Bacteroidetes S Protein conserved in bacteria - - - - - - - - - - - - - YYD3_k127_201468_4 1172188.KB911822_gene926 5.105e-25 109.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase YYD3_k127_201468_2 289376.THEYE_A0330 2.296e-36 150.0 COG1463@1|root,COG1463@2|Bacteria,3J164@40117|Nitrospirae 40117|Nitrospirae Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD YYD3_k127_201468_0 1162668.LFE_1729 1.863e-62 224.0 COG1127@1|root,COG1127@2|Bacteria,3J12B@40117|Nitrospirae 40117|Nitrospirae Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran YYD3_k127_201468_1 1123376.AUIU01000013_gene1806 1.585e-51 190.0 COG0767@1|root,COG0767@2|Bacteria,3J15A@40117|Nitrospirae 40117|Nitrospirae Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE YYD3_k127_2037307_2 1379698.RBG1_1C00001G1345 5.784e-99 336.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria 2|Bacteria KT COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - GAF,GAF_2,HATPase_c_2,SSF,SpoIIE YYD3_k127_2037307_1 706587.Desti_4421 3.069e-151 492.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2MQ8K@213462|Syntrophobacterales 28221|Deltaproteobacteria L PFAM MgsA AAA ATPase C terminal rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N YYD3_k127_2037307_0 1379698.RBG1_1C00001G0426 9.809e-165 527.0 2CD20@1|root,2Z7SQ@2|Bacteria,2NNUF@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_2037307_3 404589.Anae109_2485 7.39e-68 235.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,42MQB@68525|delta/epsilon subdivisions,2WPIA@28221|Deltaproteobacteria,2Z34C@29|Myxococcales 28221|Deltaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase YYD3_k127_2037307_5 491205.JARQ01000008_gene3729 1.95e-15 84.0 COG1670@1|root,COG1670@2|Bacteria,4NQZQ@976|Bacteroidetes,1I3J3@117743|Flavobacteriia,3ZQJV@59732|Chryseobacterium 976|Bacteroidetes J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 YYD3_k127_2037307_6 68223.JNZY01000019_gene7351 1.806e-11 72.0 2D579@1|root,32TID@2|Bacteria,2IMWE@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - YYD3_k127_2037307_4 1278073.MYSTI_07636 5.479e-25 109.0 COG3386@1|root,COG3386@2|Bacteria,1NFEJ@1224|Proteobacteria,43BX0@68525|delta/epsilon subdivisions,2X77S@28221|Deltaproteobacteria,2YVY8@29|Myxococcales 28221|Deltaproteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - YYD3_k127_2082405_1 1004149.AFOE01000028_gene1803 1.106e-26 126.0 COG1044@1|root,COG1044@2|Bacteria,4PNZT@976|Bacteroidetes,1IKCC@117743|Flavobacteriia 976|Bacteroidetes M chitinase - - - - - - - - - - - - - YYD3_k127_2082405_2 421531.IX38_00975 6.138e-10 72.0 COG5295@1|root,COG5295@2|Bacteria,4NHCC@976|Bacteroidetes,1I2VF@117743|Flavobacteriia,3ZUIF@59732|Chryseobacterium 976|Bacteroidetes UW Hep Hag repeat protein - - - - - - - - - - - - Collagen YYD3_k127_2082405_0 1379698.RBG1_1C00001G0272 7.99e-43 163.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - - - - - - - - - - - AHSA1,DUF2505 YYD3_k127_2092346_2 187303.BN69_0849 2.888e-142 461.0 COG1453@1|root,COG1453@2|Bacteria,1NIR6@1224|Proteobacteria,2U135@28211|Alphaproteobacteria,36ZIH@31993|Methylocystaceae 28211|Alphaproteobacteria S 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 YYD3_k127_2092346_5 557599.MKAN_22965 1.369e-53 192.0 COG0664@1|root,COG0664@2|Bacteria,2IRJW@201174|Actinobacteria 201174|Actinobacteria T COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - cNMP_binding YYD3_k127_2092346_3 247490.KSU1_A0075 5.332e-121 394.0 COG0543@1|root,COG0543@2|Bacteria,2IYBB@203682|Planctomycetes 203682|Planctomycetes C Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - - - - - - - - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 YYD3_k127_2092346_4 518766.Rmar_2589 1.342e-117 383.0 COG1941@1|root,COG1941@2|Bacteria 2|Bacteria C coenzyme F420 hydrogenase activity hoxY - - - - - - - - - - - Oxidored_q6 YYD3_k127_2092346_1 247490.KSU1_A0077 1.981e-188 602.0 COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes 203682|Planctomycetes C Nickel-dependent hydrogenase - - - - - - - - - - - - NiFeSe_Hases YYD3_k127_2092346_6 247490.KSU1_A0078 9.971e-32 129.0 COG0680@1|root,COG0680@2|Bacteria,2J190@203682|Planctomycetes 203682|Planctomycetes C Hydrogenase maturation protease - - - - - - - - - - - - HycI YYD3_k127_2092346_7 335543.Sfum_3405 3.276e-16 84.0 2CEMF@1|root,33GFG@2|Bacteria,1NIQ6@1224|Proteobacteria,42X94@68525|delta/epsilon subdivisions 1224|Proteobacteria - - - - - - - - - - - - - - - YYD3_k127_2092346_0 289376.THEYE_A0131 3.345e-236 747.0 COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD YYD3_k127_2097771_4 1504672.669783731 1.624e-82 287.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,4A9JJ@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM ABC transporter related livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C YYD3_k127_2097771_6 56780.SYN_00787 1.762e-71 254.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,439ZK@68525|delta/epsilon subdivisions,2X25M@28221|Deltaproteobacteria,2MRP1@213462|Syntrophobacterales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 YYD3_k127_2097771_2 671143.DAMO_1397 3.751e-90 305.0 COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria 2|Bacteria E Branched-chain amino acid transport system / permease component livH GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iJN746.PP_4866,iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288 BPD_transp_2 YYD3_k127_2097771_3 747365.Thena_0240 1.091e-83 291.0 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,42I94@68295|Thermoanaerobacterales 186801|Clostridia E COGs COG0683 ABC-type branched-chain amino acid transport systems periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 YYD3_k127_2097771_9 795666.MW7_3482 3e-05 56.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VKXA@28216|Betaproteobacteria,1K2ZY@119060|Burkholderiaceae 28216|Betaproteobacteria S 40-residue YVTN family beta-propeller repeat protein - - - - - - - - - - - - Cytochrom_D1,Lactonase YYD3_k127_2097771_5 313612.L8106_12700 3.852e-77 283.0 COG2931@1|root,COG2931@2|Bacteria,1G0DX@1117|Cyanobacteria,1H9Z9@1150|Oscillatoriales 1117|Cyanobacteria QU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Calx-beta,DUF4347,HemolysinCabind,SdrD_B,VCBS YYD3_k127_2097771_1 880072.Desac_2636 4.59e-100 330.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales 28221|Deltaproteobacteria K PFAM response regulator receiver - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C YYD3_k127_2097771_0 1232410.KI421421_gene3404 7.081e-182 587.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,43SD2@69541|Desulfuromonadales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,sCache_like YYD3_k127_2097771_10 1131812.JQMS01000001_gene1236 0.000132 48.0 COG3746@1|root,COG3746@2|Bacteria,4NIRE@976|Bacteroidetes 976|Bacteroidetes P phosphate-selective porin O and P - - - - - - - - - - - - Porin_O_P YYD3_k127_2114201_5 1170562.Cal6303_4322 4.286e-07 57.0 2DNT7@1|root,32Z0Z@2|Bacteria,1G93V@1117|Cyanobacteria 1117|Cyanobacteria S Cysteine-rich CPXCG - - - - - - - - - - - - Cys_rich_CPXG YYD3_k127_2114201_2 1303518.CCALI_00586 2.708e-44 179.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - PMT_2 YYD3_k127_2114201_4 1121106.JQKB01000059_gene4749 4.886e-18 94.0 COG0454@1|root,COG0456@2|Bacteria,1R418@1224|Proteobacteria,2U1QH@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 YYD3_k127_2114201_3 429009.Adeg_1906 3.521e-20 99.0 COG1959@1|root,COG1959@2|Bacteria,1UT43@1239|Firmicutes,2518T@186801|Clostridia,42ID9@68295|Thermoanaerobacterales 186801|Clostridia K Transcriptional regulator - - - - - - - - - - - - Rrf2 YYD3_k127_2114201_1 1118058.CAGY01000008_gene1489 2.755e-104 351.0 COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4D45F@85005|Actinomycetales 201174|Actinobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0008150,GO:0040007 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA YYD3_k127_2114201_0 643867.Ftrac_0001 1.857e-121 404.0 COG0593@1|root,COG0593@2|Bacteria,4NE6Q@976|Bacteroidetes,47KR6@768503|Cytophagia 976|Bacteroidetes L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N YYD3_k127_212194_1 391612.CY0110_21405 1.195e-53 203.0 COG2304@1|root,COG2304@2|Bacteria,1G1BE@1117|Cyanobacteria,3KIB3@43988|Cyanothece 1117|Cyanobacteria S Von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA YYD3_k127_212194_3 631362.Thi970DRAFT_00460 4.221e-19 94.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - MerR_1 YYD3_k127_212194_2 903818.KI912268_gene3050 2.788e-31 126.0 COG0735@1|root,COG0735@2|Bacteria,3Y7UH@57723|Acidobacteria 57723|Acidobacteria P Ferric uptake regulator family - - - ko:K09825 - - - - ko00000,ko03000 - - - FUR YYD3_k127_212194_0 138119.DSY1012 0.0 1024.0 COG0376@1|root,COG0376@2|Bacteria,1TQDA@1239|Firmicutes,24DM7@186801|Clostridia,260RF@186807|Peptococcaceae 186801|Clostridia P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase YYD3_k127_2153779_5 1089550.ATTH01000001_gene2205 9.64e-15 88.0 COG4775@1|root,COG4775@2|Bacteria,4P624@976|Bacteroidetes,1FIN0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Surface antigen - - - - - - - - - - - - Bac_surface_Ag YYD3_k127_2153779_3 1379698.RBG1_1C00001G0634 2.798e-46 174.0 COG1051@1|root,COG1051@2|Bacteria,2NPZ5@2323|unclassified Bacteria 2|Bacteria F NUDIX domain - - - - - - - - - - - - NUDIX,Nudix_N_2 YYD3_k127_2153779_1 1379698.RBG1_1C00001G1345 1.608e-49 201.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria 2|Bacteria KT COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - GAF,GAF_2,HATPase_c_2,SSF,SpoIIE YYD3_k127_2153779_4 1379698.RBG1_1C00001G0633 1.826e-32 131.0 COG2172@1|root,COG2172@2|Bacteria,2NQ1S@2323|unclassified Bacteria 2|Bacteria T Anti-sigma regulatory factor (Ser Thr protein kinase) - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2,SpoIIE YYD3_k127_2153779_2 1379698.RBG1_1C00001G0632 1.155e-47 173.0 COG1366@1|root,COG1366@2|Bacteria,2NRCS@2323|unclassified Bacteria 2|Bacteria T STAS domain rsbV - - ko:K04749 - - - - ko00000,ko03021 - - - STAS,STAS_2 YYD3_k127_2153779_0 316067.Geob_1970 4.693e-200 643.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,43TM8@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 YYD3_k127_2171466_3 1379698.RBG1_1C00001G1377 2.879e-112 391.0 COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase YYD3_k127_2171466_5 589865.DaAHT2_1264 0.0005787 45.0 COG0316@1|root,COG0316@2|Bacteria,1N8FK@1224|Proteobacteria,42VBF@68525|delta/epsilon subdivisions,2WR7Y@28221|Deltaproteobacteria,2MKZ6@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the HesB IscA family - - - - - - - - - - - - Fe-S_biosyn YYD3_k127_2171466_4 926550.CLDAP_26360 9.325e-49 194.0 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2G7I4@200795|Chloroflexi 200795|Chloroflexi UW Hep Hag repeat protein - - - - - - - - - - - - - YYD3_k127_2171466_2 926549.KI421517_gene464 8.423e-129 418.0 COG0667@1|root,COG0667@2|Bacteria,4NEDK@976|Bacteroidetes,47N20@768503|Cytophagia 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red YYD3_k127_2171466_0 1379698.RBG1_1C00001G1511 1.534e-202 640.0 COG0312@1|root,COG0312@2|Bacteria,2NPIS@2323|unclassified Bacteria 2|Bacteria S Putative modulator of DNA gyrase tldD2 - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD YYD3_k127_2171466_1 1379698.RBG1_1C00001G1510 4.127e-146 475.0 COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria 2|Bacteria S Putative modulator of DNA gyrase tldE2 - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD YYD3_k127_2182235_0 338969.Rfer_2335 9.947e-203 642.0 COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,4AD4J@80864|Comamonadaceae 28216|Betaproteobacteria C Berberine and berberine like - - - - - - - - - - - - BBE,FAD_binding_4 YYD3_k127_2182235_1 879212.DespoDRAFT_00420 2.065e-36 141.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42Q4I@68525|delta/epsilon subdivisions,2WKRP@28221|Deltaproteobacteria,2MHRB@213118|Desulfobacterales 28221|Deltaproteobacteria E Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 YYD3_k127_2187428_0 316274.Haur_3591 1.195e-42 169.0 COG4948@1|root,COG4948@2|Bacteria,2G882@200795|Chloroflexi,3757P@32061|Chloroflexia 2|Bacteria M mandelate racemase muconate lactonizing ycjG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - iEC042_1314.EC042_1441,iECUMN_1333.ECUMN_1620 MR_MLE_C,MR_MLE_N YYD3_k127_2187428_1 1173020.Cha6605_4588 1.883e-18 99.0 COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,1G08T@1117|Cyanobacteria 1117|Cyanobacteria M N-acetylmuramoyl-L-alanine amidase amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,SH3_4 YYD3_k127_2209501_5 338966.Ppro_2179 1.928e-19 91.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,42P59@68525|delta/epsilon subdivisions,2WJUJ@28221|Deltaproteobacteria,43W2K@69541|Desulfuromonadales 28221|Deltaproteobacteria S Conserved hypothetical protein 698 - - - - - - - - - - - - Cons_hypoth698 YYD3_k127_2209501_4 1333998.M2A_0798 2.11e-71 260.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2U0BA@28211|Alphaproteobacteria,4BT4A@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_2 YYD3_k127_2209501_3 1313172.YM304_31360 7.884e-90 305.0 COG0693@1|root,COG3119@1|root,COG0693@2|Bacteria,COG3119@2|Bacteria,2IA3D@201174|Actinobacteria 201174|Actinobacteria P Sulfatase - - - - - - - - - - - - Sulfatase YYD3_k127_2209501_6 399795.CtesDRAFT_PD2168 5.892e-16 87.0 COG2067@1|root,COG2067@2|Bacteria,1RDE4@1224|Proteobacteria,2VVWG@28216|Betaproteobacteria 28216|Betaproteobacteria I long-chain fatty acid transport protein - - - - - - - - - - - - YfaZ YYD3_k127_2209501_0 1300345.LF41_901 2.869e-134 453.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XDED@135614|Xanthomonadales 135614|Xanthomonadales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Sigma54_activat YYD3_k127_2209501_1 247490.KSU1_C0842 1.76e-110 383.0 COG0308@1|root,COG0308@2|Bacteria 2|Bacteria E peptide catabolic process - - - - - - - - - - - iAF987.Gmet_0348 Cofac_haem_bdg,PDZ_2,Peptidase_M1,Peptidase_M28 YYD3_k127_2209501_2 1121430.JMLG01000019_gene1656 3.524e-92 315.0 COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,24CA4@186801|Clostridia,260IP@186807|Peptococcaceae 186801|Clostridia S RmuC family rmuC - - ko:K09760 - - - - ko00000 - - - RmuC YYD3_k127_2231159_0 1379698.RBG1_1C00001G1773 3.509e-94 331.0 COG0457@1|root,COG0457@2|Bacteria,2NP5J@2323|unclassified Bacteria 2|Bacteria S Oxygen tolerance - - - - - - - - - - - - BatD YYD3_k127_2231159_3 1121931.AUHG01000010_gene401 1.335e-29 128.0 COG0457@1|root,COG0457@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia 976|Bacteroidetes T tetratricopeptide repeat batE - - - - - - - - - - - SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2 YYD3_k127_2231159_2 1379698.RBG1_1C00001G1771 5.723e-50 192.0 COG0392@1|root,COG0392@2|Bacteria 2|Bacteria M lysyltransferase activity mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM YYD3_k127_2231159_1 2325.TKV_c18590 4.45e-63 229.0 COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,24DE3@186801|Clostridia,42F3P@68295|Thermoanaerobacterales 186801|Clostridia P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA YYD3_k127_2233485_0 518766.Rmar_2323 3.447e-49 180.0 COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,1FIMG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form - - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 YYD3_k127_2233485_1 1379698.RBG1_1C00001G0226 2.966e-40 161.0 COG1729@1|root,COG1729@2|Bacteria,2NPUR@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 YYD3_k127_2268490_2 1231190.NA8A_07004 2.873e-11 65.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TUS8@28211|Alphaproteobacteria,43H9R@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E ABC transporter afuC2 - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 YYD3_k127_2268490_1 1384049.CD29_05015 2.711e-60 223.0 COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,4HA0W@91061|Bacilli,3IWYA@400634|Lysinibacillus 91061|Bacilli L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N YYD3_k127_2268490_0 1379698.RBG1_1C00001G0265 6.966e-123 404.0 COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria 2|Bacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 ko:K02338,ko:K03610 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03036,ko03400,ko04812 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 YYD3_k127_2287619_1 1379698.RBG1_1C00001G0995 1.754e-63 238.0 COG5617@1|root,COG5617@2|Bacteria,2NS5H@2323|unclassified Bacteria 2|Bacteria E Bacterial membrane protein YfhO - - - - - - - - - - - - YfhO YYD3_k127_2287619_0 1379698.RBG1_1C00001G1315 4.719e-84 289.0 COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 arnC - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 YYD3_k127_2329022_6 880073.Calab_0310 3.439e-122 396.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 2|Bacteria C Polysulphide reductase, NrfD actC - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD YYD3_k127_2329022_12 518766.Rmar_0224 9.584e-47 174.0 COG2010@1|root,COG2010@2|Bacteria,4NEX9@976|Bacteroidetes,1FJ8P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Protein of unknown function (DUF3341) actD - - - - - - - - - - - DUF3341 YYD3_k127_2329022_9 880073.Calab_0308 7.302e-71 245.0 COG2010@1|root,COG2010@2|Bacteria,2NPQJ@2323|unclassified Bacteria 2|Bacteria C Cytochrome C oxidase, cbb3-type, subunit III actE - - - - - - - - - - - Cytochrome_CBB3 YYD3_k127_2329022_3 1519464.HY22_05025 3.309e-135 441.0 COG4531@1|root,COG4531@2|Bacteria 2|Bacteria P zinc ion transport actF - - - - - - - - - - - - YYD3_k127_2329022_8 518766.Rmar_0228 2.208e-77 269.0 COG1999@1|root,COG1999@2|Bacteria,4NU1J@976|Bacteroidetes,1FJ7I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S signal sequence binding - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC YYD3_k127_2329022_5 880073.Calab_0304 3.381e-123 402.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2NNSH@2323|unclassified Bacteria 2|Bacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275,ko:K17223 ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120 M00155,M00595 R00081,R10151 RC00016,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C YYD3_k127_2329022_1 880073.Calab_0303 1.722e-251 786.0 COG0843@1|root,COG0843@2|Bacteria,2NNTQ@2323|unclassified Bacteria 2|Bacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxA - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 YYD3_k127_2329022_7 880073.Calab_0302 2.375e-89 299.0 COG1845@1|root,COG1845@2|Bacteria,2NPIG@2323|unclassified Bacteria 2|Bacteria C cytochrome c oxidase subunit III coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 YYD3_k127_2329022_15 880073.Calab_0301 3.039e-23 105.0 2ASAK@1|root,31HPU@2|Bacteria,2NQ6K@2323|unclassified Bacteria 2|Bacteria S Prokaryotic Cytochrome C oxidase subunit IV - - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - COX4_pro YYD3_k127_2329022_11 517418.Ctha_2324 5.671e-65 241.0 COG1612@1|root,COG1612@2|Bacteria 2|Bacteria O heme a metabolic process ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA YYD3_k127_2329022_14 880073.Calab_0299 1.838e-43 177.0 COG1999@1|root,COG1999@2|Bacteria,2NQ63@2323|unclassified Bacteria 2|Bacteria O SCO1/SenC ypmQ - - ko:K07152,ko:K08976 - - - - ko00000,ko03029 - - - SCO1-SenC YYD3_k127_2329022_13 880073.Calab_0298 9.647e-45 166.0 COG2322@1|root,COG2322@2|Bacteria 2|Bacteria S membrane yozB - - ko:K07152,ko:K08976 - - - - ko00000,ko03029 - - - DUF420 YYD3_k127_2329022_17 1120968.AUBX01000016_gene1747 4.741e-15 90.0 COG1470@1|root,COG1470@2|Bacteria,4NFPN@976|Bacteroidetes,47M4H@768503|Cytophagia 976|Bacteroidetes S CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 YYD3_k127_2329022_4 1379698.RBG1_1C00001G1670 1.504e-133 439.0 COG1228@1|root,COG1228@2|Bacteria,2NR87@2323|unclassified Bacteria 2|Bacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 YYD3_k127_2329022_0 1123054.KB907706_gene2275 5.332e-299 949.0 COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,1RRK7@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 YYD3_k127_2329022_2 760568.Desku_0178 2.103e-169 540.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24DPN@186801|Clostridia,260G2@186807|Peptococcaceae 186801|Clostridia I TIGRFAM Acetoacetyl-CoA synthase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C YYD3_k127_2329022_10 886293.Sinac_0959 1.821e-67 233.0 COG0176@1|root,COG0176@2|Bacteria,2IYC8@203682|Planctomycetes 203682|Planctomycetes H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA YYD3_k127_2351136_1 880073.Calab_1556 6.341e-12 76.0 COG2067@1|root,COG2067@2|Bacteria,2NR34@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - YYD3_k127_2351136_0 1379698.RBG1_1C00001G0488 1.137e-23 110.0 COG4447@1|root,COG4447@2|Bacteria,2NRAH@2323|unclassified Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - CHU_C,Cu_amine_oxidN1,F5_F8_type_C YYD3_k127_2354367_2 1006004.GBAG_2397 2.091e-09 60.0 COG0110@1|root,COG0110@2|Bacteria,1RF1T@1224|Proteobacteria,1S4DA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0110 Acetyltransferase (isoleucine patch superfamily) lacA - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac YYD3_k127_2354367_1 118173.KB235914_gene3853 4.471e-24 112.0 COG2755@1|root,COG2755@2|Bacteria,1G31T@1117|Cyanobacteria,1H8QX@1150|Oscillatoriales 1117|Cyanobacteria E PFAM GDSL-like Lipase Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 YYD3_k127_2354367_0 871968.DESME_14465 4.347e-62 231.0 COG0438@1|root,COG0438@2|Bacteria,1V0G0@1239|Firmicutes,25BFP@186801|Clostridia 186801|Clostridia M Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 YYD3_k127_2354367_3 880073.Calab_1364 1.767e-07 58.0 COG2244@1|root,COG2244@2|Bacteria,2NQ4Y@2323|unclassified Bacteria 2|Bacteria S Polysaccharide biosynthesis protein cap - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C YYD3_k127_2361016_1 1341151.ASZU01000008_gene1531 5.698e-07 59.0 COG1783@1|root,COG1783@2|Bacteria,1VK0H@1239|Firmicutes,4HQ2H@91061|Bacilli 91061|Bacilli S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C YYD3_k127_2361016_0 880073.Calab_0041 7.531e-26 122.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase YYD3_k127_2370413_0 349741.Amuc_1222 6.134e-110 367.0 COG1297@1|root,COG1297@2|Bacteria,46TNW@74201|Verrucomicrobia,2IV9P@203494|Verrucomicrobiae 203494|Verrucomicrobiae S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT YYD3_k127_2370413_2 1395587.P364_0130440 1.312e-44 178.0 COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,4HAVC@91061|Bacilli,26RDF@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08420 GlutR_N,GlutR_dimer,Shikimate_DH YYD3_k127_2370413_1 1408433.JHXV01000019_gene1919 4.269e-75 264.0 COG0181@1|root,COG0181@2|Bacteria,4NHH4@976|Bacteroidetes,1HXKZ@117743|Flavobacteriia,2PB12@246874|Cryomorphaceae 976|Bacteroidetes H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - HEM4,Porphobil_deam,Porphobil_deamC YYD3_k127_2370413_4 866895.HBHAL_3678 3.948e-21 102.0 COG1587@1|root,COG1587@2|Bacteria,1UHSJ@1239|Firmicutes,4HFY4@91061|Bacilli,3NE80@45667|Halobacillus 91061|Bacilli H Uroporphyrinogen-III synthase HemD hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 YYD3_k127_2370413_3 903818.KI912268_gene3331 1.832e-34 136.0 COG0113@1|root,COG0113@2|Bacteria,3Y2VK@57723|Acidobacteria 57723|Acidobacteria H PFAM delta-aminolevulinic acid dehydratase - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD YYD3_k127_2383973_6 1379698.RBG1_1C00001G1445 7.482e-07 53.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NQSG@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - BSP,Bac_surface_Ag,PD40,Peptidase_MA_2 YYD3_k127_2383973_2 760568.Desku_0258 4.8e-103 344.0 COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,2617J@186807|Peptococcaceae 186801|Clostridia C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM YYD3_k127_2383973_4 671143.DAMO_1641 1.528e-57 219.0 COG0241@1|root,COG0859@1|root,COG0241@2|Bacteria,COG0859@2|Bacteria,2NPK4@2323|unclassified Bacteria 2|Bacteria E D,D-heptose 1,7-bisphosphate phosphatase rfaF - 2.7.1.167,2.7.7.70,3.1.3.82,3.1.3.83,5.3.1.28 ko:K02841,ko:K02843,ko:K02849,ko:K03271,ko:K03272,ko:K03273 ko00540,ko01100,map00540,map01100 M00064,M00080 R05644,R05645,R05646,R05647,R09768,R09769,R09771 RC00002,RC00017,RC00078,RC00434 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9,Hydrolase_like YYD3_k127_2383973_3 1123070.KB899250_gene465 1.76e-67 238.0 COG1968@1|root,COG1968@2|Bacteria,46SP6@74201|Verrucomicrobia,2IURU@203494|Verrucomicrobiae 203494|Verrucomicrobiae V Bacitracin resistance protein BacA uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA YYD3_k127_2383973_1 945713.IALB_2034 4.388e-159 516.0 COG0733@1|root,COG0733@2|Bacteria 2|Bacteria S neurotransmitter:sodium symporter activity - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF YYD3_k127_2383973_0 1379698.RBG1_1C00001G0987 1.248e-163 527.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02481,ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_2391994_9 326427.Cagg_2140 6.362e-12 68.0 COG0524@1|root,COG0524@2|Bacteria,2GAA6@200795|Chloroflexi,376QU@32061|Chloroflexia 32061|Chloroflexia G PFAM PfkB domain protein - - - - - - - - - - - - PfkB YYD3_k127_2391994_0 211165.AJLN01000100_gene4293 3.537e-190 604.0 arCOG06766@1|root,2Z87F@2|Bacteria,1G1NX@1117|Cyanobacteria,1JKSG@1189|Stigonemataceae 1117|Cyanobacteria - - - - - - - - - - - - - - - YYD3_k127_2391994_6 384765.SIAM614_20910 5.303e-37 142.0 COG0073@1|root,COG0073@2|Bacteria,1RGU7@1224|Proteobacteria,2U9AH@28211|Alphaproteobacteria 28211|Alphaproteobacteria J COG0073 EMAP domain csaA - - ko:K06878 - - - - ko00000 - - - tRNA_bind YYD3_k127_2391994_7 1265505.ATUG01000002_gene974 1.4e-29 127.0 COG1102@1|root,COG1102@2|Bacteria,1RCTZ@1224|Proteobacteria,42R0B@68525|delta/epsilon subdivisions,2WMVD@28221|Deltaproteobacteria,2MJH5@213118|Desulfobacterales 28221|Deltaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 YYD3_k127_2391994_3 1007103.AFHW01000001_gene4886 1.317e-57 210.0 COG2227@1|root,COG2227@2|Bacteria,1VAV7@1239|Firmicutes,4HPRU@91061|Bacilli,277FW@186822|Paenibacillaceae 91061|Bacilli H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 YYD3_k127_2391994_4 1379698.RBG1_1C00001G1857 2.623e-55 207.0 COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ YYD3_k127_2391994_1 1379698.RBG1_1C00001G1858 1.793e-107 363.0 COG0795@1|root,COG0795@2|Bacteria,2NP9S@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ family protein lptF GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K07091,ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - iECED1_1282.ECED1_5114,iUMNK88_1353.UMNK88_5207 YjgP_YjgQ YYD3_k127_2391994_2 1191523.MROS_0556 1.557e-58 216.0 COG3481@1|root,COG3481@2|Bacteria 2|Bacteria D metal-dependent phosphohydrolase, HD sub domain yhaM - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,tRNA_anti-codon YYD3_k127_2391994_5 558169.AGAV01000005_gene2214 5.397e-46 170.0 COG0346@1|root,COG0346@2|Bacteria,1V48E@1239|Firmicutes,4HHUT@91061|Bacilli 91061|Bacilli E COG0346 Lactoylglutathione lyase and related lyases yurT - - - - - - - - - - - Glyoxalase YYD3_k127_2391994_10 903818.KI912268_gene1852 2.561e-10 66.0 COG2203@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3852@2|Bacteria,3Y9EC@57723|Acidobacteria 2|Bacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg YYD3_k127_2391994_8 1123020.AUIE01000002_gene1564 5.919e-17 96.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RQIN@1236|Gammaproteobacteria,1YEEY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain dctB - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 YYD3_k127_2396601_0 1210884.HG799463_gene9317 4.282e-110 391.0 COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg YYD3_k127_2396601_1 864051.BurJ1DRAFT_0752 3.987e-19 88.0 COG3291@1|root,COG3291@2|Bacteria,1RGWM@1224|Proteobacteria,2W2XV@28216|Betaproteobacteria 28216|Betaproteobacteria M Bacterial pre-peptidase C-terminal domain - - - - - - - - - - - - PPC YYD3_k127_2403692_6 204669.Acid345_1814 7.342e-16 85.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,3Y62K@57723|Acidobacteria,2JMK5@204432|Acidobacteriia 204432|Acidobacteriia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg YYD3_k127_2403692_3 1379698.RBG1_1C00001G0958 7.814e-62 223.0 COG1561@1|root,COG1561@2|Bacteria,2NPG5@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF1732) yicC - - ko:K03316 - - - - ko00000 2.A.36 - - DUF1732,YicC_N YYD3_k127_2403692_5 653733.Selin_2413 1.224e-43 166.0 COG0194@1|root,COG0194@2|Bacteria 2|Bacteria F guanylate kinase activity gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin YYD3_k127_2403692_0 1379698.RBG1_1C00001G0961 1.346e-276 870.0 COG0550@1|root,COG0550@2|Bacteria,2NNS8@2323|unclassified Bacteria 2|Bacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom YYD3_k127_2403692_4 592010.GCWU000182_001546 4.635e-50 190.0 COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4HARA@91061|Bacilli,27DTX@186827|Aerococcaceae 91061|Bacilli D Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase YYD3_k127_2403692_2 373903.Hore_07560 5.153e-62 218.0 COG5405@1|root,COG5405@2|Bacteria,1TPXK@1239|Firmicutes,24FS4@186801|Clostridia,3WAJD@53433|Halanaerobiales 186801|Clostridia O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome YYD3_k127_2403692_1 1499967.BAYZ01000097_gene4376 4.119e-132 430.0 COG1220@1|root,COG1220@2|Bacteria,2NP00@2323|unclassified Bacteria 2|Bacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small YYD3_k127_2404357_2 1379698.RBG1_1C00001G0347 1.144e-79 273.0 COG1657@1|root,COG1657@2|Bacteria,2NP7R@2323|unclassified Bacteria 2|Bacteria I Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159,Prenyltrans YYD3_k127_2404357_3 1232410.KI421420_gene3141 1.738e-61 218.0 COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2WMZT@28221|Deltaproteobacteria,43SGD@69541|Desulfuromonadales 28221|Deltaproteobacteria P UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N YYD3_k127_2404357_0 338963.Pcar_0086 2.882e-98 336.0 COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,43S5D@69541|Desulfuromonadales 28221|Deltaproteobacteria P Cation transport protein ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH YYD3_k127_2404357_1 373994.Riv7116_2299 1.303e-91 307.0 COG4221@1|root,COG4221@2|Bacteria,1G182@1117|Cyanobacteria,1HICK@1161|Nostocales 1117|Cyanobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.276 ko:K05886 - - - - ko00000,ko01000 - - - adh_short YYD3_k127_2404357_5 1008457.BAEX01000035_gene2311 3.127e-40 162.0 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia,47HU4@76831|Myroides 976|Bacteroidetes M Peptidase family M23 mepM_1 - - - - - - - - - - - Peptidase_M23 YYD3_k127_2404357_4 1379698.RBG1_1C00001G1702 5.563e-45 173.0 COG1595@1|root,COG1595@2|Bacteria,2NR5Q@2323|unclassified Bacteria 2|Bacteria K RNA polymerase sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 YYD3_k127_2404357_6 1538644.KO02_18970 2.232e-37 152.0 COG0642@1|root,COG2205@2|Bacteria,4NK58@976|Bacteroidetes,1IPNM@117747|Sphingobacteriia 976|Bacteroidetes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA YYD3_k127_2404717_8 309799.DICTH_1910 2.358e-11 67.0 COG0021@1|root,COG0021@2|Bacteria 2|Bacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N YYD3_k127_2404717_1 330214.NIDE2204 1.155e-115 381.0 COG1023@1|root,COG1023@2|Bacteria 2|Bacteria G D-gluconate metabolic process gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 YYD3_k127_2404717_0 1128421.JAGA01000002_gene1842 2.038e-168 543.0 COG0364@1|root,COG0364@2|Bacteria,2NNUR@2323|unclassified Bacteria 2|Bacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N YYD3_k127_2404717_5 1191523.MROS_0019 7.294e-42 156.0 COG0393@1|root,COG0393@2|Bacteria 2|Bacteria S Putative heavy-metal-binding ybjQ - - - - - - - - - - - YbjQ_1 YYD3_k127_2404717_6 1183438.GKIL_4241 1.462e-41 163.0 COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria 1117|Cyanobacteria G 6-phosphogluconolactonase pgl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso YYD3_k127_2404717_4 1183438.GKIL_2876 1.388e-64 232.0 COG0837@1|root,COG0837@2|Bacteria,1G1TJ@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase YYD3_k127_2404717_7 525904.Tter_1225 9.633e-17 89.0 COG1564@1|root,COG1564@2|Bacteria,2NPUG@2323|unclassified Bacteria 2|Bacteria H Thiamin pyrophosphokinase, vitamin B1 binding domain thiN - 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 - R00619 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TPK_B1_binding,TPK_catalytic YYD3_k127_2404717_2 1121957.ATVL01000014_gene1459 9.551e-107 376.0 COG5563@1|root,COG5563@2|Bacteria,4PHUI@976|Bacteroidetes,47VHU@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_2404717_10 1121935.AQXX01000066_gene2370 0.0002091 55.0 COG3488@1|root,COG3488@2|Bacteria 2|Bacteria C Di-haem oxidoreductase, putative peroxidase - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - DHOR,Glyco_hydro_16 YYD3_k127_2404717_3 1278073.MYSTI_07405 4.516e-88 297.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42ZGK@68525|delta/epsilon subdivisions,2WUTG@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD3_k127_2404717_9 1242864.D187_003879 8.066e-07 51.0 COG1682@1|root,COG1682@2|Bacteria,1QXTH@1224|Proteobacteria,42XN1@68525|delta/epsilon subdivisions,2WSPR@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane YYD3_k127_2407425_8 1280689.AUJC01000007_gene3114 0.000314 51.0 COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,36DMG@31979|Clostridiaceae 186801|Clostridia S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 YYD3_k127_2407425_7 1313265.JNIE01000003_gene1301 1.629e-20 105.0 COG3746@1|root,COG3746@2|Bacteria,2G4NR@200783|Aquificae 200783|Aquificae P phosphate-selective porin O and P - - - - - - - - - - - - - YYD3_k127_2407425_2 1379698.RBG1_1C00001G0108 3.065e-76 266.0 COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria 2|Bacteria P Belongs to the bacterial solute-binding protein 9 family znuA - - ko:K02077,ko:K09815,ko:K09818 ko02010,map02010 M00242,M00243,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ZnuA YYD3_k127_2407425_3 234267.Acid_0827 1.504e-68 242.0 COG1108@1|root,COG1108@2|Bacteria,3Y93X@57723|Acidobacteria 57723|Acidobacteria P ABC 3 transport family - - - ko:K02075 - M00244 - - ko00000,ko00002,ko02000 3.A.1.15 - - ABC-3 YYD3_k127_2407425_0 1304874.JAFY01000002_gene661 1.316e-177 564.0 COG0477@1|root,COG2814@2|Bacteria,3TACG@508458|Synergistetes 508458|Synergistetes EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 YYD3_k127_2407425_5 1380394.JADL01000003_gene5071 8.982e-38 152.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_25 YYD3_k127_2407425_6 1121445.ATUZ01000014_gene1484 7.244e-27 111.0 2B2V5@1|root,31VFQ@2|Bacteria,1QCMA@1224|Proteobacteria,436BA@68525|delta/epsilon subdivisions,2X0WD@28221|Deltaproteobacteria,2MDKE@213115|Desulfovibrionales 28221|Deltaproteobacteria S Pathogenicity locus - - - - - - - - - - - - Cdd1 YYD3_k127_2407425_4 880073.Calab_2227 6.037e-44 168.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - 1.11.1.15,2.7.13.3 ko:K03564,ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - AhpC-TSA YYD3_k127_2407425_1 237368.SCABRO_00479 2.176e-109 366.0 COG0426@1|root,COG0426@2|Bacteria,2J2P2@203682|Planctomycetes 203682|Planctomycetes C Flavodoxin - - - - - - - - - - - - Flavodoxin_1,Lactamase_B YYD3_k127_241508_2 1379698.RBG1_1C00001G1194 3.452e-46 183.0 COG2911@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - 3.2.1.91 ko:K14194,ko:K19668 ko00500,ko01100,ko02020,ko05150,map00500,map01100,map02020,map05150 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CHU_C,DUF11,FlgD_ig,PKD,SdrD_B YYD3_k127_241508_0 1480694.DC28_08795 7.463e-102 341.0 COG1351@1|root,COG1351@2|Bacteria,2J68R@203691|Spirochaetes 203691|Spirochaetes F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 YYD3_k127_241508_1 1210884.HG799462_gene8232 6.324e-62 220.0 COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes 203682|Planctomycetes E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 YYD3_k127_2418720_3 2754.EH55_09345 4.46e-79 271.0 COG0674@1|root,COG0674@2|Bacteria,3TA6A@508458|Synergistetes 508458|Synergistetes C ferredoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N YYD3_k127_2418720_2 555079.Toce_1203 8.081e-101 336.0 COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,42F7D@68295|Thermoanaerobacterales 186801|Clostridia C Best Blastp hit gi 6685602 sp Q57957 KORB_METJA 2-OXOGLUTARATE SYNTHASE SUBUNIT KORB (2-KETOGLUTARATE OXIDOREDUCTASE BETA CHAIN) (KOR) (2-OXOGLUTARATE-FERREDOXIN OXIDOREDUCTASE BETA SUBUNIT) gi 2129229 pir A64367 pyruvate synthase (EC 1.2.7.1) beta chain - Methanococcus jannaschii gi 1591241 gb AAB98531.1 '(U67503) 2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB) Methanococcus jannaschii ', score korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C YYD3_k127_2418720_5 909663.KI867149_gene3458 3.922e-53 193.0 COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,2MRMB@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase korC - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR YYD3_k127_2418720_6 1051646.VITU9109_21764 5.879e-42 157.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1XX25@135623|Vibrionales 135623|Vibrionales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK YYD3_k127_2418720_4 1236689.MMALV_14900 5.925e-60 224.0 COG3875@1|root,arCOG02046@2157|Archaea,2XVDD@28890|Euryarchaeota 28890|Euryarchaeota S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 YYD3_k127_2418720_1 1379698.RBG1_1C00001G1803 1.513e-128 417.0 COG0039@1|root,COG0039@2|Bacteria,2NNY8@2323|unclassified Bacteria 2|Bacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0004470,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1360 Ldh_1_C,Ldh_1_N YYD3_k127_2418720_0 1379698.RBG1_1C00001G1802 1.587e-183 582.0 COG0538@1|root,COG0538@2|Bacteria,2NS4M@2323|unclassified Bacteria 2|Bacteria C Isocitrate/isopropylmalate dehydrogenase icd GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh YYD3_k127_2418720_7 926551.KB900739_gene62 1.096e-12 77.0 2EGT8@1|root,33AJC@2|Bacteria,4NY9U@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_2423869_8 1385935.N836_22860 5.831e-13 69.0 COG4446@1|root,COG4446@2|Bacteria,1G6W2@1117|Cyanobacteria,1HBIQ@1150|Oscillatoriales 1117|Cyanobacteria S COGs COG4446 conserved - - - - - - - - - - - - DUF1499 YYD3_k127_2423869_9 1476583.DEIPH_ctg018orf0061 8.774e-06 49.0 COG1024@1|root,COG1024@2|Bacteria,1WJ7Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 YYD3_k127_2423869_2 1121930.AQXG01000003_gene2498 2.018e-99 329.0 COG0519@1|root,COG0519@2|Bacteria,4NESX@976|Bacteroidetes,1INX4@117747|Sphingobacteriia 976|Bacteroidetes F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase YYD3_k127_2423869_3 74545.EU96_1521 1.504e-60 216.0 COG3914@1|root,COG3914@2|Bacteria 2|Bacteria O protein N-acetylglucosaminyltransferase activity - - - - - - - - - - - - Methyltransf_21,Sulfotransfer_3 YYD3_k127_2423869_7 518766.Rmar_0873 1.355e-22 104.0 COG0816@1|root,COG0816@2|Bacteria,4NQ8B@976|Bacteroidetes,1FJID@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA ruvX GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX YYD3_k127_2423869_4 330214.NIDE1709 7.609e-55 207.0 COG1559@1|root,COG1559@2|Bacteria,3J0IR@40117|Nitrospirae 40117|Nitrospirae S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG YYD3_k127_2423869_1 1255043.TVNIR_2752 4.512e-109 370.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWGD@135613|Chromatiales 135613|Chromatiales T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_2423869_6 264732.Moth_2010 4.721e-23 101.0 COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,42GW8@68295|Thermoanaerobacterales 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln YYD3_k127_2423869_5 373903.Hore_18930 3.136e-51 193.0 COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,24H2B@186801|Clostridia,3WAKF@53433|Halanaerobiales 186801|Clostridia M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 YYD3_k127_2423869_0 1379698.RBG1_1C00001G0542 1.484e-219 691.0 COG0504@1|root,COG0504@2|Bacteria,2NNVG@2323|unclassified Bacteria 2|Bacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377 CTP_synth_N,GATase YYD3_k127_243125_2 743299.Acife_0077 6.888e-29 117.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,2NBX5@225057|Acidithiobacillales 225057|Acidithiobacillales C FAD linked oxidases, C-terminal domain - - 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 YYD3_k127_243125_0 7159.AAEL011789-PB 1.473e-134 442.0 COG0372@1|root,KOG2617@2759|Eukaryota,38CK5@33154|Opisthokonta,3BCNS@33208|Metazoa,3CZN5@33213|Bilateria,41WA3@6656|Arthropoda,3SG56@50557|Insecta,44XIG@7147|Diptera,45D6Y@7148|Nematocera 33208|Metazoa H citrate synthase CS GO:0003674,GO:0003824,GO:0004108,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0006082,GO:0006084,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0014823,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046483,GO:0046912,GO:0050896,GO:0051186,GO:0055086,GO:0055114,GO:0070013,GO:0071704,GO:0072350,GO:0072521,GO:1901135,GO:1901360,GO:1901564 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt YYD3_k127_243125_1 1379698.RBG1_1C00001G1238 2.427e-94 334.0 COG5000@1|root,COG5000@2|Bacteria,2NQEP@2323|unclassified Bacteria 2|Bacteria T COGs COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,dCache_1 YYD3_k127_243125_3 557598.LHK_01395 3.732e-11 66.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VI6T@28216|Betaproteobacteria,2KPFJ@206351|Neisseriales 206351|Neisseriales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_8 YYD3_k127_2515898_3 744872.Spica_1618 5.153e-05 47.0 COG1197@1|root,COG1197@2|Bacteria,2J63X@203691|Spirochaetes 203691|Spirochaetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF YYD3_k127_2515898_1 1121396.KB893071_gene1269 2.35e-41 156.0 COG1014@1|root,COG1014@2|Bacteria,1R92Y@1224|Proteobacteria,42QJI@68525|delta/epsilon subdivisions,2WMFZ@28221|Deltaproteobacteria,2MJ4M@213118|Desulfobacterales 28221|Deltaproteobacteria C TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family - - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR YYD3_k127_2515898_0 255470.cbdbA845 2.261e-43 164.0 COG1905@1|root,COG1905@2|Bacteria,2G6Q5@200795|Chloroflexi,34CKC@301297|Dehalococcoidia 301297|Dehalococcoidia C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx YYD3_k127_2515898_2 246194.CHY_0732 3.868e-33 133.0 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales 186801|Clostridia C NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB YYD3_k127_2528511_1 1379698.RBG1_1C00001G1524 3.646e-77 287.0 COG2911@1|root,COG2911@2|Bacteria,2NQ89@2323|unclassified Bacteria 2|Bacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K07277,ko:K09800 - - - - ko00000,ko02000,ko03029 1.B.33 - - AsmA_2,DUF748,TamB YYD3_k127_2528511_6 379066.GAU_1903 4.505e-25 113.0 COG0599@1|root,COG0599@2|Bacteria,1ZTPF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD YYD3_k127_2528511_7 653733.Selin_1769 2.96e-22 109.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity degP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 YYD3_k127_2528511_9 639030.JHVA01000001_gene1961 0.0002737 51.0 COG5662@1|root,COG5662@2|Bacteria,3Y4JS@57723|Acidobacteria,2JJ7U@204432|Acidobacteriia 204432|Acidobacteriia K AntiSigma factor - - - - - - - - - - - - zf-HC2 YYD3_k127_2528511_4 518766.Rmar_2628 9.215e-39 153.0 COG1595@1|root,COG1595@2|Bacteria,4NQE0@976|Bacteroidetes,1FISP@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K TIGRFAM RNA polymerase sigma factor, sigma-70 family rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD3_k127_2528511_3 243231.GSU1012 1.011e-51 199.0 COG1906@1|root,COG1906@2|Bacteria,1RAQQ@1224|Proteobacteria,42QZ0@68525|delta/epsilon subdivisions,2WMXK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF401) - - - ko:K09133 - - - - ko00000 - - - DUF401 YYD3_k127_2528511_0 1121324.CLIT_2c01880 7.573e-80 284.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,25QW7@186804|Peptostreptococcaceae 186801|Clostridia EH Anthranilate synthase component I, N terminal region pabB - 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01657,ko:K01665,ko:K03342,ko:K13950 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Anth_synt_I_N,Chorismate_bind YYD3_k127_2528511_5 1123508.JH636439_gene573 1.856e-37 152.0 COG0115@1|root,COG0115@2|Bacteria,2IY3N@203682|Planctomycetes 203682|Planctomycetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 YYD3_k127_2528511_2 1379698.RBG1_1C00001G1526 1.357e-56 207.0 2CBA8@1|root,30BZT@2|Bacteria,2NR2H@2323|unclassified Bacteria 2|Bacteria S Exopolysaccharide biosynthesis protein YbjH - - - - - - - - - - - - YjbH YYD3_k127_2528511_8 1085623.GNIT_0218 1.216e-10 64.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,1SITE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase YYD3_k127_254275_0 1191523.MROS_0219 9.91e-137 443.0 COG0480@1|root,COG0480@2|Bacteria 2|Bacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 YYD3_k127_254275_1 861299.J421_2770 2.51e-58 206.0 COG0049@1|root,COG0049@2|Bacteria,1ZSQZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 YYD3_k127_2550305_5 1379698.RBG1_1C00001G0733 1.667e-53 205.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_2550305_7 272123.Anacy_0627 8.704e-50 199.0 COG4870@1|root,COG4870@2|Bacteria 2|Bacteria O transferase activity, transferring glycosyl groups - - 3.4.22.15 ko:K01365,ko:K14475 ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418 - - - ko00000,ko00001,ko00537,ko01000,ko01002,ko03110 - - - Inhibitor_I42,Peptidase_C1 YYD3_k127_2550305_3 1193181.BN10_50002 4.599e-62 245.0 COG4412@1|root,COG4412@2|Bacteria,2GMKQ@201174|Actinobacteria 201174|Actinobacteria M PFAM peptidase M6, immune inhibitor A - - - - - - - - - - - - Peptidase_M6 YYD3_k127_2550305_10 388467.A19Y_0366 1.737e-28 121.0 COG1853@1|root,COG1853@2|Bacteria,1G2RV@1117|Cyanobacteria,1H7U3@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct YYD3_k127_2550305_2 552811.Dehly_0101 5.818e-78 272.0 COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi,34CIH@301297|Dehalococcoidia 301297|Dehalococcoidia C Radical SAM domain protein - - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - - YYD3_k127_2550305_0 1121438.JNJA01000001_gene2267 6.289e-241 761.0 COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2M85I@213115|Desulfovibrionales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 YYD3_k127_2550305_4 997346.HMPREF9374_1644 3.1e-56 206.0 COG4976@1|root,COG4976@2|Bacteria,1V582@1239|Firmicutes,4HI2P@91061|Bacilli 91061|Bacilli S Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 YYD3_k127_2550305_8 1382304.JNIL01000001_gene2641 1.747e-44 165.0 COG0454@1|root,COG0454@2|Bacteria,1V6N8@1239|Firmicutes,4HITB@91061|Bacilli,27AE7@186823|Alicyclobacillaceae 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 YYD3_k127_2550305_12 1167006.UWK_02302 0.0002856 53.0 COG1996@1|root,COG1996@2|Bacteria,1R71V@1224|Proteobacteria,42PRX@68525|delta/epsilon subdivisions,2WMQY@28221|Deltaproteobacteria,2MIG3@213118|Desulfobacterales 28221|Deltaproteobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - YYD3_k127_2550305_1 269799.Gmet_0754 2.616e-99 338.0 COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,43UZT@69541|Desulfuromonadales 28221|Deltaproteobacteria S SPFH domain-Band 7 family - - - - - - - - - - - - Band_7_1,DUF4339,DZR,SHOCT,zinc_ribbon_2 YYD3_k127_2550305_11 667014.Thein_1751 3.225e-25 117.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2 YYD3_k127_2550305_9 1121352.JHZP01000001_gene551 1.025e-28 125.0 COG2849@1|root,COG2849@2|Bacteria,1RJZH@1224|Proteobacteria,2VT1T@28216|Betaproteobacteria,2KRHY@206351|Neisseriales 206351|Neisseriales S MORN repeat protein - - - - - - - - - - - - MORN_2 YYD3_k127_2550305_6 1500301.JQMF01000024_gene2043 1.951e-50 185.0 COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,2VG87@28211|Alphaproteobacteria,4BNHK@82115|Rhizobiaceae 28211|Alphaproteobacteria S Flavodoxin-like fold - - - - - - - - - - - - FMN_red YYD3_k127_255741_0 56780.SYN_00152 2.569e-206 650.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MR61@213462|Syntrophobacterales 28221|Deltaproteobacteria C NADH ubiquinone oxidoreductase, NADH-binding - - 1.12.1.3,1.6.5.3 ko:K00124,ko:K00335,ko:K18331 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB YYD3_k127_255741_1 335541.Swol_1700 1.187e-50 189.0 COG3383@1|root,COG3383@2|Bacteria,1V5BD@1239|Firmicutes,24ER9@186801|Clostridia 186801|Clostridia C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - iHN637.CLJU_RS03470 Fer2_4,Fer4,Fer4_21,Fer4_7 YYD3_k127_255741_2 589924.Ferp_1231 9.099e-39 150.0 COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2477Y@183980|Archaeoglobi 183980|Archaeoglobi C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_11 YYD3_k127_2598335_3 326424.FRAAL3988 3.885e-10 64.0 2E897@1|root,332N4@2|Bacteria,2I89V@201174|Actinobacteria 201174|Actinobacteria S Pfam:DUF946 - - - - - - - - - - - - Toxin_10,Vps62 YYD3_k127_2598335_1 272134.KB731324_gene2342 3.061e-52 191.0 COG1670@1|root,COG1670@2|Bacteria,1G5HU@1117|Cyanobacteria,1HB9F@1150|Oscillatoriales 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 YYD3_k127_2598335_4 710696.Intca_0330 4.63e-06 59.0 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - - - - - - - - - - Asp_protease_2,VWA,VWA_2 YYD3_k127_2598335_2 153948.NAL212_0962 3.178e-12 79.0 COG2304@1|root,COG2304@2|Bacteria,1PE8B@1224|Proteobacteria,2WC99@28216|Betaproteobacteria,374H0@32003|Nitrosomonadales 28216|Betaproteobacteria S C-type lectin (CTL) or carbohydrate-recognition domain (CRD) - - - - - - - - - - - - VPEP YYD3_k127_2598335_0 945713.IALB_0006 4.596e-92 309.0 COG0188@1|root,COG0188@2|Bacteria 2|Bacteria L DNA topoisomerase II activity gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV YYD3_k127_2600765_1 311424.DhcVS_1405 2.493e-08 65.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,2G7Y4@200795|Chloroflexi,34DMA@301297|Dehalococcoidia 301297|Dehalococcoidia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg YYD3_k127_2600765_0 945713.IALB_0461 3.658e-83 304.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family aprN - - - - - - - - - - - Peptidase_S8 YYD3_k127_2611500_1 1279009.ADICEAN_00451 6.738e-110 359.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,47MI5@768503|Cytophagia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO YYD3_k127_2611500_2 929556.Solca_1393 1.165e-54 199.0 COG2010@1|root,COG2010@2|Bacteria,4NFMJ@976|Bacteroidetes,1IRZW@117747|Sphingobacteriia 976|Bacteroidetes C PFAM Cytochrome c, class I ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N YYD3_k127_2611500_0 1121904.ARBP01000002_gene7145 6.833e-151 488.0 COG0348@1|root,COG0348@2|Bacteria,4NFDN@976|Bacteroidetes,47KT1@768503|Cytophagia 976|Bacteroidetes C TIGRFAM cytochrome c oxidase accessory protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C YYD3_k127_2622257_2 871968.DESME_14455 3.179e-58 216.0 COG0438@1|root,COG0438@2|Bacteria,1TSNT@1239|Firmicutes,248MH@186801|Clostridia,26327@186807|Peptococcaceae 186801|Clostridia M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 YYD3_k127_2622257_0 234267.Acid_4860 4.594e-91 313.0 COG0399@1|root,COG0399@2|Bacteria,3Y2QT@57723|Acidobacteria 57723|Acidobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 YYD3_k127_2622257_1 886293.Sinac_6637 5.686e-75 263.0 COG1163@1|root,COG1163@2|Bacteria,2IWYP@203682|Planctomycetes 203682|Planctomycetes S TGS domain - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,TGS YYD3_k127_2622257_3 1379698.RBG1_1C00001G0432 1.266e-38 158.0 2BV2G@1|root,32QFC@2|Bacteria,2NR6X@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_2626709_1 314285.KT71_11209 1.012e-85 296.0 2DCFR@1|root,2ZDYQ@2|Bacteria,1RB5X@1224|Proteobacteria,1RN4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_2626709_0 264201.pc1763 8.209e-86 300.0 COG0621@1|root,COG0621@2|Bacteria,2JFUS@204428|Chlamydiae 204428|Chlamydiae J Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine mtaB - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 YYD3_k127_2626709_2 1191523.MROS_1880 2.977e-26 110.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria 2|Bacteria M UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K02535,ko:K13599,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,ko02020,map00061,map00540,map00780,map01100,map01212,map02020 M00060,M00083,M00498,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005,ko02022 - - - FabA,LpxC YYD3_k127_2628185_0 1282361.ABAC402_09290 7.648e-05 55.0 29XIV@1|root,30J9U@2|Bacteria,1NN8G@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - YYD3_k127_2629620_4 1123508.JH636443_gene5018 4.319e-53 189.0 COG3324@1|root,COG3324@2|Bacteria,2J3W8@203682|Planctomycetes 203682|Planctomycetes S Glyoxalase-like domain - - - ko:K06996 - - - - ko00000 - - - - YYD3_k127_2629620_6 1379698.RBG1_1C00001G1804 3.315e-48 176.0 2E8AI@1|root,332PD@2|Bacteria,2NRHQ@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_2629620_9 1379698.RBG1_1C00001G1805 5.019e-14 76.0 COG1826@1|root,COG1826@2|Bacteria,2NQ3N@2323|unclassified Bacteria 2|Bacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 YYD3_k127_2629620_1 1121930.AQXG01000010_gene3038 9.274e-98 324.0 COG0047@1|root,COG0047@2|Bacteria,4NFER@976|Bacteroidetes,1IRA4@117747|Sphingobacteriia 976|Bacteroidetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 YYD3_k127_2629620_8 1379698.RBG1_1C00001G1808 4.544e-21 95.0 COG1828@1|root,COG1828@2|Bacteria,2NQ45@2323|unclassified Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU06460 PurS YYD3_k127_2629620_3 1379698.RBG1_1C00001G1809 1.178e-68 242.0 COG1183@1|root,COG1183@2|Bacteria,2NPQM@2323|unclassified Bacteria 2|Bacteria I CDP-alcohol phosphatidyltransferase pssA - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf YYD3_k127_2629620_5 56780.SYN_00913 1.652e-51 190.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,42QDS@68525|delta/epsilon subdivisions,2WMQ3@28221|Deltaproteobacteria,2MQID@213462|Syntrophobacterales 28221|Deltaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase YYD3_k127_2629620_0 404380.Gbem_2333 1.11e-153 500.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,43TS7@69541|Desulfuromonadales 28221|Deltaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 YYD3_k127_2629620_2 573063.Metin_1349 1.221e-86 292.0 COG0176@1|root,arCOG05061@2157|Archaea,2XTET@28890|Euryarchaeota,23Q23@183939|Methanococci 183939|Methanococci F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA YYD3_k127_2644524_4 639030.JHVA01000001_gene3473 0.0008178 50.0 COG1587@1|root,COG2203@1|root,COG1587@2|Bacteria,COG2203@2|Bacteria,3Y68Z@57723|Acidobacteria,2JK7D@204432|Acidobacteriia 204432|Acidobacteriia T ANTAR - - - - - - - - - - - - ANTAR,GAF,GAF_2,HEM4 YYD3_k127_2644524_3 1304885.AUEY01000022_gene3410 6.889e-13 74.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales 28221|Deltaproteobacteria T response regulator receiver ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_2644524_1 1120998.AUFC01000016_gene52 4.708e-25 109.0 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,3WD27@538999|Clostridiales incertae sedis 186801|Clostridia T Sigma-54 interaction domain - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_2644524_0 665571.STHERM_c09350 4.669e-59 222.0 COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes 203691|Spirochaetes L COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain - - - ko:K09749 - - - - ko00000 - - - FapA,Jag_N YYD3_k127_2644524_2 1415779.JOMH01000001_gene1373 5.608e-23 108.0 COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,1RZN8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 YYD3_k127_2652512_1 1379698.RBG1_1C00001G1152 7.953e-30 123.0 COG0195@1|root,COG0195@2|Bacteria,2NNV1@2323|unclassified Bacteria 2|Bacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 YYD3_k127_2652512_2 1379698.RBG1_1C00001G1151 5.903e-19 91.0 COG0779@1|root,COG0779@2|Bacteria,2NPVA@2323|unclassified Bacteria 2|Bacteria S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C YYD3_k127_2652512_0 1379698.RBG1_1C00001G1150 3.496e-142 463.0 COG0442@1|root,COG0442@2|Bacteria,2NNNH@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iJN678.proS,iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit YYD3_k127_2654437_3 1191523.MROS_0164 6.555e-144 464.0 COG0002@1|root,COG0002@2|Bacteria 2|Bacteria E N-acetyl-gamma-glutamyl-phosphate reductase activity argC - 1.2.1.38 ko:K00145,ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R03443,R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC YYD3_k127_2654437_5 880073.Calab_0345 8.297e-137 439.0 COG0189@1|root,COG0189@2|Bacteria,2NNM4@2323|unclassified Bacteria 2|Bacteria HJ Belongs to the RimK family lysX - 6.3.1.17,6.3.2.32,6.3.2.41,6.3.2.43 ko:K05827,ko:K05844,ko:K14940,ko:K18310 ko00250,ko00300,ko00680,ko01100,ko01120,ko01210,ko01230,map00250,map00300,map00680,map01100,map01120,map01210,map01230 M00031 R09401,R09775,R10677,R10678 RC00064,RC00090,RC00141,RC03233 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RimK YYD3_k127_2654437_4 1191523.MROS_0166 7.087e-140 454.0 COG0119@1|root,COG0119@2|Bacteria 2|Bacteria E Belongs to the alpha-IPM synthase homocitrate synthase family leuA3 - 2.3.3.13,2.3.3.14 ko:K01649,ko:K01655 ko00290,ko00300,ko00620,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00620,map01100,map01110,map01120,map01130,map01210,map01230 M00030,M00432,M00433 R00271,R01213 RC00004,RC00067,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like YYD3_k127_2654437_12 1191523.MROS_0167 1.309e-17 85.0 2DRHT@1|root,33BTG@2|Bacteria 2|Bacteria S lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - YYD3_k127_2654437_2 880073.Calab_3330 3.212e-151 490.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,2NS2I@2323|unclassified Bacteria 2|Bacteria O Pyridine nucleotide-disulphide oxidoreductase trxB_2 - 1.18.1.2,1.19.1.1,1.8.1.9 ko:K00384,ko:K21567 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Fer4,Fer4_10,Pyr_redox_3 YYD3_k127_2654437_7 880073.Calab_3331 1.886e-92 325.0 2919D@1|root,2ZNWG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_2654437_0 204669.Acid345_0471 7.425e-203 653.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - - YYD3_k127_2654437_1 880073.Calab_3334 1.062e-188 607.0 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - Cytochrom_CIII,Cytochrom_c3_2,Cytochrome_C7 YYD3_k127_2654437_8 880073.Calab_3335 1.209e-62 226.0 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity - - - - - - - - - - - - FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding YYD3_k127_2654437_9 1121378.KB899773_gene622 1.525e-39 167.0 28HH2@1|root,33750@2|Bacteria 2|Bacteria M Thiol-activated cytolysin - - - ko:K11031 ko02024,map02024 - - - ko00000,ko00001,ko02042 - - - Thiol_cytolysin YYD3_k127_2654437_13 1506583.JQJY01000005_gene2134 4.409e-06 58.0 2E0CU@1|root,32VZP@2|Bacteria,4NUGS@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_2654437_11 867845.KI911784_gene2290 8.616e-26 117.0 COG1266@1|root,COG1266@2|Bacteria,2G7NB@200795|Chloroflexi,377D7@32061|Chloroflexia 32061|Chloroflexia S CAAX protease self-immunity - - - - - - - - - - - - Abi YYD3_k127_2654437_6 1403313.AXBR01000009_gene751 5.509e-106 351.0 COG2321@1|root,COG2321@2|Bacteria,1TQKF@1239|Firmicutes,4HB7I@91061|Bacilli,1ZCSY@1386|Bacillus 91061|Bacilli S Putative neutral zinc metallopeptidase XK27_03670 - - ko:K07054 - - - - ko00000 - - - Zn_peptidase YYD3_k127_2654437_10 391603.FBALC1_08338 1.667e-30 134.0 COG5640@1|root,COG5640@2|Bacteria,4P71W@976|Bacteroidetes,1IBSM@117743|Flavobacteriia 976|Bacteroidetes O Trypsin-like serine protease - - - - - - - - - - - - Trypsin YYD3_k127_2663895_0 880073.Calab_2995 3.447e-186 592.0 COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria 2|Bacteria O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C YYD3_k127_2663895_2 686340.Metal_2831 2.853e-29 123.0 COG1943@1|root,COG1943@2|Bacteria,1PUZT@1224|Proteobacteria,1TAPE@1236|Gammaproteobacteria,1XGFG@135618|Methylococcales 135618|Methylococcales L Transposase IS200 like - - - - - - - - - - - - Y1_Tnp YYD3_k127_2663895_1 945713.IALB_1083 3.205e-43 179.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Calx-beta,CarboxypepD_reg,LVIVD,TSP_3 YYD3_k127_2664400_1 1121468.AUBR01000002_gene642 4.8e-142 461.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,42F24@68295|Thermoanaerobacterales 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme YYD3_k127_2664400_5 1321784.HMPREF1987_01353 1.124e-45 174.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia 186801|Clostridia F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC YYD3_k127_2664400_7 344747.PM8797T_28824 1.189e-12 70.0 2EPX9@1|root,33HHS@2|Bacteria,2J4DJ@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD3_k127_2664400_4 1379698.RBG1_1C00001G1047 3.043e-49 181.0 COG1913@1|root,COG1913@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K06974 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M54 YYD3_k127_2664400_0 1379698.RBG1_1C00001G1048 1.851e-310 967.0 COG1205@1|root,COG1205@2|Bacteria,2NNKJ@2323|unclassified Bacteria 2|Bacteria L Domain of unknown function (DUF1998) yprA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C YYD3_k127_2664400_2 1379698.RBG1_1C00001G1558 5.73e-57 205.0 COG1974@1|root,COG1974@2|Bacteria,2NPJG@2323|unclassified Bacteria 2|Bacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 YYD3_k127_2664400_3 797303.Natpe_2206 6.625e-56 215.0 COG0534@1|root,arCOG01731@2157|Archaea,2XU54@28890|Euryarchaeota,23SKQ@183963|Halobacteria 183963|Halobacteria V COG0534 Na -driven multidrug efflux pump - - - - - - - - - - - - MatE YYD3_k127_2664400_6 70448.A0A090M4R4 1.483e-37 143.0 COG3808@1|root,2QPJC@2759|Eukaryota,37IY7@33090|Viridiplantae,34K0E@3041|Chlorophyta 3041|Chlorophyta C H -translocating - - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - H_PPase YYD3_k127_2675517_2 880073.Calab_1128 4.013e-30 131.0 COG1404@1|root,COG1629@1|root,COG1404@2|Bacteria,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - Alpha-amylase,Big_2,CBM_25,Calx-beta,P_proprotein,Peptidase_S8,SBBP,SLH,TonB_dep_Rec,VCBS YYD3_k127_2675517_1 722419.PH505_bq00020 7.496e-40 167.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria,2Q0ZC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB YYD3_k127_2675517_0 635013.TherJR_1754 1.15e-132 437.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,2603X@186807|Peptococcaceae 186801|Clostridia NU PFAM Type II secretion system protein E - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N YYD3_k127_2707698_2 265072.Mfla_0846 1.018e-59 211.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,2VKI3@28216|Betaproteobacteria,2KKSZ@206350|Nitrosomonadales 206350|Nitrosomonadales G Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - Hydrolase_6,Hydrolase_like YYD3_k127_2707698_0 880073.Calab_2557 1.735e-99 340.0 COG0477@1|root,COG2814@2|Bacteria,2NS3M@2323|unclassified Bacteria 2|Bacteria EGP Transmembrane secretion effector bacE - - - - - - - - - - - MFS_1,MFS_3 YYD3_k127_2707698_3 530564.Psta_3588 6.61e-43 164.0 COG0817@1|root,COG0817@2|Bacteria,2IZJS@203682|Planctomycetes 203682|Planctomycetes L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC YYD3_k127_2707698_4 1123508.JH636445_gene6795 4.311e-28 121.0 COG0632@1|root,COG0632@2|Bacteria,2IZ2E@203682|Planctomycetes 203682|Planctomycetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N YYD3_k127_2707698_1 196367.JNFG01000006_gene7016 1.677e-79 271.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1K2TQ@119060|Burkholderiaceae 28216|Betaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N YYD3_k127_2724837_1 1123252.ATZF01000005_gene3936 2.344e-99 337.0 COG3424@1|root,COG3424@2|Bacteria,1TPUK@1239|Firmicutes,4HBHH@91061|Bacilli,27B3Q@186824|Thermoactinomycetaceae 91061|Bacilli Q Chalcone and stilbene synthases, N-terminal domain bcsA - - ko:K16167 - - - - ko00000,ko01008 - - - Chal_sti_synt_C,Chal_sti_synt_N YYD3_k127_2724837_3 1131462.DCF50_p2216 9.925e-28 116.0 COG1917@1|root,COG1917@2|Bacteria,1VDBA@1239|Firmicutes,24NXM@186801|Clostridia,262NC@186807|Peptococcaceae 186801|Clostridia S AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 YYD3_k127_2724837_2 1247726.MIM_c18140 1.745e-47 184.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,3T295@506|Alcaligenaceae 28216|Betaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport YYD3_k127_2724837_4 1089544.KB912942_gene490 8.603e-15 80.0 COG3324@1|root,COG3324@2|Bacteria,2IRUY@201174|Actinobacteria,4E63A@85010|Pseudonocardiales 201174|Actinobacteria S PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase YYD3_k127_2724837_0 1382356.JQMP01000001_gene1276 6.681e-123 404.0 COG0451@1|root,COG0451@2|Bacteria,2G5PB@200795|Chloroflexi 200795|Chloroflexi M Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - Epimerase YYD3_k127_2724837_5 1396141.BATP01000057_gene3074 0.0005996 51.0 COG0265@1|root,COG0265@2|Bacteria,46XAI@74201|Verrucomicrobia,2IUH0@203494|Verrucomicrobiae 203494|Verrucomicrobiae O Trypsin - - - - - - - - - - - - PDZ_2,Trypsin_2 YYD3_k127_2726008_4 1379698.RBG1_1C00001G1235 6.068e-26 122.0 COG1470@1|root,COG1470@2|Bacteria 2|Bacteria S cell adhesion involved in biofilm formation - - - - - - - - - - - - CarbopepD_reg_2 YYD3_k127_2726008_2 1340493.JNIF01000003_gene4469 1.3e-42 178.0 COG1305@1|root,COG1305@2|Bacteria,3Y3A2@57723|Acidobacteria 57723|Acidobacteria E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core YYD3_k127_2726008_5 240015.ACP_0078 4.401e-20 106.0 COG1305@1|root,COG1305@2|Bacteria,3Y2TK@57723|Acidobacteria,2JHX7@204432|Acidobacteriia 204432|Acidobacteriia E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core YYD3_k127_2726008_1 1379698.RBG1_1C00001G1491 1.522e-101 341.0 COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria 2|Bacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K03705 - - - - ko00000,ko03000 - - - HTH_DeoR,HrcA,HrcA_DNA-bdg YYD3_k127_2726008_3 1280663.ATVR01000029_gene3062 2.041e-34 140.0 COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,4BX70@830|Butyrivibrio 186801|Clostridia O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE YYD3_k127_2726008_0 1379698.RBG1_1C00001G1489 1.277e-268 833.0 COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria 2|Bacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 YYD3_k127_2727285_2 1463921.JODF01000023_gene665 6.238e-21 94.0 COG1032@1|root,COG1032@2|Bacteria,2IC05@201174|Actinobacteria 201174|Actinobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM YYD3_k127_2727285_1 1379698.RBG1_1C00001G1476 8.13e-81 280.0 COG1703@1|root,COG1703@2|Bacteria,2NP56@2323|unclassified Bacteria 2|Bacteria E LAO AO transport system ATPase argK - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK YYD3_k127_2727285_0 1379698.RBG1_1C00001G1477 4.634e-175 567.0 COG0608@1|root,COG0608@2|Bacteria,2NNRX@2323|unclassified Bacteria 2|Bacteria L single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 YYD3_k127_2727285_4 1094715.CM001373_gene1338 1.543e-09 61.0 2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - YYD3_k127_2727285_3 1304284.L21TH_1818 1.436e-20 92.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,36DCY@31979|Clostridiaceae 186801|Clostridia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO YYD3_k127_2739657_4 1469557.JSWF01000035_gene1012 3.394e-06 49.0 COG0256@1|root,COG0256@2|Bacteria,4NQAS@976|Bacteroidetes,1I2S3@117743|Flavobacteriia 976|Bacteroidetes J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p YYD3_k127_2739657_2 1379698.RBG1_1C00001G1329 2.979e-49 196.0 COG2199@1|root,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria 2|Bacteria T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GAF_2,GGDEF,PAS_4,PAS_9,PocR,Response_reg YYD3_k127_2739657_3 1379698.RBG1_1C00001G1332 1.594e-44 171.0 COG1366@1|root,COG1366@2|Bacteria,2NR50@2323|unclassified Bacteria 2|Bacteria T Anti-sigma factor antagonist - - - ko:K04749,ko:K06378 - - - - ko00000,ko03021 - - - STAS,STAS_2 YYD3_k127_2739657_0 1379698.RBG1_1C00001G1333 1.348e-88 317.0 COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2NP51@2323|unclassified Bacteria 2|Bacteria KT Sigma factor PP2C-like phosphatases pkn5 - 2.7.11.1,3.1.3.3 ko:K04757,ko:K07315 - - - - ko00000,ko01000,ko01001,ko03021 - - - AAA_16,GAF,HAMP,HATPase_c_2,Pkinase,SpoIIE,dCache_1 YYD3_k127_2739657_1 1379698.RBG1_1C00001G1334 2.64e-87 312.0 COG2067@1|root,COG2067@2|Bacteria,2NQKU@2323|unclassified Bacteria 2|Bacteria I Tetratricopeptide repeat - - - - - - - - - - - - TPR_2 YYD3_k127_2747628_3 1519464.HY22_13445 2.567e-61 217.0 COG0109@1|root,COG0109@2|Bacteria 2|Bacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA YYD3_k127_2747628_2 1396418.BATQ01000137_gene3876 6.452e-67 234.0 COG3880@1|root,COG3880@2|Bacteria,46SMN@74201|Verrucomicrobia,2IU6R@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 YYD3_k127_2747628_0 880073.Calab_0311 0.0 1062.0 COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S dicluster domain hybA - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding YYD3_k127_2747628_1 880073.Calab_0310 1.607e-115 380.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 2|Bacteria C Polysulphide reductase, NrfD actC - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD YYD3_k127_2747628_5 374847.Kcr_1364 2.64e-08 65.0 arCOG03671@1|root,arCOG03671@2157|Archaea 2157|Archaea S Parallel beta-helix repeats - - - - - - - - - - - - Thermopsin YYD3_k127_2747628_4 497964.CfE428DRAFT_6157 4.347e-23 110.0 COG1361@1|root,COG1520@1|root,COG1572@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG4934@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1572@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,COG4934@2|Bacteria 2|Bacteria O collagen metabolic process - - - ko:K08677 - - - - ko00000,ko01002 - - - CHU_C,DUF11,Pro-kuma_activ,SdrD_B YYD3_k127_2756936_3 1379698.RBG1_1C00001G1819 5.095e-97 351.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_2756936_8 880073.Calab_3408 5.02e-17 88.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - Cytochrome_C554,DUF11,SLH YYD3_k127_2756936_4 880073.Calab_0603 1.482e-72 262.0 COG0438@1|root,COG0438@2|Bacteria,2NQ20@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferases group 1 - - - ko:K00786 - - - - ko00000,ko01000 - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 YYD3_k127_2756936_0 880073.Calab_1670 1.894e-157 509.0 COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine csdA - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 YYD3_k127_2756936_1 1453500.AT05_06665 1.294e-132 431.0 COG0381@1|root,COG0381@2|Bacteria,4NGBD@976|Bacteroidetes,1HXDA@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - 5.1.3.23 ko:K13019 ko00520,map00520 - R09600 RC00290 ko00000,ko00001,ko01000,ko01005 - - - Epimerase_2 YYD3_k127_2756936_6 709991.Odosp_3064 2.131e-32 134.0 COG1704@1|root,COG1704@2|Bacteria,4NMD3@976|Bacteroidetes,2FNPV@200643|Bacteroidia,22XSI@171551|Porphyromonadaceae 976|Bacteroidetes S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA YYD3_k127_2756936_5 700598.Niako_5140 5.48e-37 151.0 COG1512@1|root,COG1512@2|Bacteria,4NF4P@976|Bacteroidetes,1IQMF@117747|Sphingobacteriia 976|Bacteroidetes S COG1512 Beta-propeller domains of methanol dehydrogenase type - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase YYD3_k127_2756936_7 1346791.M529_07510 4.069e-21 105.0 COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2U5XG@28211|Alphaproteobacteria,2K470@204457|Sphingomonadales 204457|Sphingomonadales S membrane - - - ko:K08988 - - - - ko00000 - - - TPM_phosphatase YYD3_k127_2756936_2 290397.Adeh_0511 3.886e-105 354.0 COG0475@1|root,COG0475@2|Bacteria,1RA3J@1224|Proteobacteria,43EWJ@68525|delta/epsilon subdivisions,2WTW1@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger YYD3_k127_2764618_2 1121422.AUMW01000003_gene848 1.203e-69 241.0 COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,249MP@186801|Clostridia,260KG@186807|Peptococcaceae 186801|Clostridia C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig YYD3_k127_2764618_1 565033.GACE_2119 2.644e-89 308.0 COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,245UY@183980|Archaeoglobi 183980|Archaeoglobi C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA YYD3_k127_2764618_3 497964.CfE428DRAFT_3991 4.467e-59 217.0 2CAZH@1|root,2Z7RU@2|Bacteria,46SY1@74201|Verrucomicrobia 74201|Verrucomicrobia - - sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt YYD3_k127_2764618_0 234267.Acid_7402 1.037e-152 488.0 COG1053@1|root,COG1053@2|Bacteria,3Y2MQ@57723|Acidobacteria 57723|Acidobacteria C Succinate dehydrogenase or fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C YYD3_k127_2786952_0 1379698.RBG1_1C00001G0983 6.633e-169 544.0 COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria 2|Bacteria J Ribonuclease E/G family rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 YYD3_k127_2786952_1 1191523.MROS_2423 8.945e-79 274.0 COG0223@1|root,COG0223@2|Bacteria 2|Bacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N YYD3_k127_2790163_0 314278.NB231_16563 7.757e-151 485.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1X0CA@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran YYD3_k127_2790163_3 404589.Anae109_4263 1.309e-92 324.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2YZUC@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23 YYD3_k127_2790163_5 690850.Desaf_2671 4.217e-19 101.0 COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,42PU9@68525|delta/epsilon subdivisions,2WU8U@28221|Deltaproteobacteria,2M8K7@213115|Desulfovibrionales 28221|Deltaproteobacteria MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP YYD3_k127_2790163_1 1125863.JAFN01000001_gene1446 2.561e-139 463.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_2790163_4 237368.SCABRO_01552 7.005e-53 199.0 COG4191@1|root,COG4191@2|Bacteria,2IZY8@203682|Planctomycetes 203682|Planctomycetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA YYD3_k127_2790163_6 335543.Sfum_1432 3.398e-17 88.0 COG3350@1|root,COG3350@2|Bacteria,1NE2T@1224|Proteobacteria,42VZQ@68525|delta/epsilon subdivisions,2WSDU@28221|Deltaproteobacteria 28221|Deltaproteobacteria S YHS domain - - - - - - - - - - - - YHS YYD3_k127_2790163_2 1379698.RBG1_1C00001G0518 3.347e-102 359.0 COG0515@1|root,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 YYD3_k127_2805430_4 880073.Calab_0984 4.111e-86 302.0 COG0265@1|root,COG0265@2|Bacteria,2NQK9@2323|unclassified Bacteria 2|Bacteria O Trypsin degQ - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD3_k127_2805430_9 861299.J421_3911 1.645e-24 116.0 COG4758@1|root,COG4758@2|Bacteria 2|Bacteria KT membrane yvqF - - ko:K11622 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2154 YYD3_k127_2805430_11 485913.Krac_4641 7.835e-12 76.0 COG3595@1|root,COG3595@2|Bacteria,2G9KA@200795|Chloroflexi 200795|Chloroflexi S Putative adhesin - - - - - - - - - - - - DUF4097 YYD3_k127_2805430_6 1379698.RBG1_1C00001G1704 5.714e-70 241.0 COG1595@1|root,COG1595@2|Bacteria,2NPRC@2323|unclassified Bacteria 2|Bacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD3_k127_2805430_10 504487.JCM19302_2911 6.512e-16 84.0 COG3832@1|root,COG3832@2|Bacteria,4NPKI@976|Bacteroidetes,1I28I@117743|Flavobacteriia 976|Bacteroidetes S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 YYD3_k127_2805430_8 1379698.RBG1_1C00001G1769 1.348e-25 111.0 COG0640@1|root,COG0640@2|Bacteria,2NQ1G@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 YYD3_k127_2805430_3 913325.N799_06400 5.797e-108 364.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1X37F@135614|Xanthomonadales 135614|Xanthomonadales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF YYD3_k127_2805430_0 1379698.RBG1_1C00001G1471 5.184e-265 824.0 COG4799@1|root,COG4799@2|Bacteria,2NNWQ@2323|unclassified Bacteria 2|Bacteria I carboxyl transferase pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans YYD3_k127_2805430_5 1379698.RBG1_1C00001G1472 6.041e-72 254.0 COG0491@1|root,COG0491@2|Bacteria,2NPRD@2323|unclassified Bacteria 2|Bacteria S Metallo-beta-lactamase superfamily ytnP - - - - - - - - - - - Lactamase_B YYD3_k127_2805430_2 1379698.RBG1_1C00001G1473 5.668e-136 442.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha YYD3_k127_2805430_7 1191523.MROS_0387 9.142e-57 200.0 COG2185@1|root,COG2185@2|Bacteria 2|Bacteria I cobalamin binding - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding YYD3_k127_2805430_1 1379698.RBG1_1C00001G1475 4.661e-235 739.0 COG1884@1|root,COG1884@2|Bacteria,2NNZ9@2323|unclassified Bacteria 2|Bacteria I Methylmalonyl-CoA mutase icmA - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase YYD3_k127_2805430_12 143224.JQMD01000002_gene560 2.253e-11 76.0 2EVZZ@1|root,33PDF@2|Bacteria,4P17P@976|Bacteroidetes,1I798@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_2829508_7 1519464.HY22_04170 1.067e-17 96.0 COG2304@1|root,COG2304@2|Bacteria,1FEJH@1090|Chlorobi 1090|Chlorobi S oxidoreductase activity - - - - - - - - - - - - - YYD3_k127_2829508_8 483219.LILAB_16975 5.221e-06 56.0 COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,42ZBA@68525|delta/epsilon subdivisions,2WUF4@28221|Deltaproteobacteria,2YUZP@29|Myxococcales 28221|Deltaproteobacteria S Putative glutamine amidotransferase - - - - - - - - - - - - GATase1_like YYD3_k127_2829508_0 1379698.RBG1_1C00001G1639 6.004e-92 312.0 COG0142@1|root,COG0142@2|Bacteria,2NP7G@2323|unclassified Bacteria 2|Bacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.30,2.5.1.90 ko:K00805,ko:K02523 ko00900,ko01110,map00900,map01110 - R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt YYD3_k127_2829508_5 1121904.ARBP01000017_gene5093 3.777e-35 153.0 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,47V4E@768503|Cytophagia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Fn3_assoc,Metallophos,PA14 YYD3_k127_2829508_1 1366050.N234_12310 2.101e-50 191.0 COG2267@1|root,COG2267@2|Bacteria,1R72P@1224|Proteobacteria,2WH24@28216|Betaproteobacteria,1K5AI@119060|Burkholderiaceae 28216|Betaproteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6 YYD3_k127_2829508_6 1380355.JNIJ01000020_gene3780 1.145e-34 136.0 COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,3JYUE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1428) - - - - - - - - - - - - DUF1428 YYD3_k127_2829508_2 479434.Sthe_2969 9.973e-40 158.0 COG0262@1|root,COG0262@2|Bacteria,2G8M0@200795|Chloroflexi 200795|Chloroflexi H PFAM bifunctional deaminase-reductase domain protein - - - - - - - - - - - - RibD_C YYD3_k127_2829508_3 290397.Adeh_2244 6.069e-37 144.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria 1224|Proteobacteria S Doxx family - - - ko:K15977 - - - - ko00000 - - - DoxX YYD3_k127_2829508_4 1210884.HG799471_gene14625 1.375e-36 141.0 COG3832@1|root,COG3832@2|Bacteria,2J16I@203682|Planctomycetes 203682|Planctomycetes S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 YYD3_k127_284491_1 1379698.RBG1_1C00001G1633 1.438e-208 657.0 COG0423@1|root,COG0423@2|Bacteria,2NNN9@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSB619.SA_RS07880 HGTP_anticodon,tRNA-synt_2b YYD3_k127_284491_6 373903.Hore_12480 6.487e-17 91.0 COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,3WAT7@53433|Halanaerobiales 186801|Clostridia L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N YYD3_k127_284491_0 187272.Mlg_2286 3.944e-246 783.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C YYD3_k127_284491_3 273068.TTE0628 5.347e-51 189.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,42GDM@68295|Thermoanaerobacterales 186801|Clostridia D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 YYD3_k127_284491_2 760142.Hipma_1670 7.772e-144 467.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2M6Y2@213113|Desulfurellales 28221|Deltaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt YYD3_k127_284491_5 1462527.CCDM010000002_gene695 1.032e-22 108.0 COG2162@1|root,COG2162@2|Bacteria,1VA4Y@1239|Firmicutes,4HKYP@91061|Bacilli 91061|Bacilli Q N-acetyltransferase - - - - - - - - - - - - Acetyltransf_2 YYD3_k127_2871438_3 1047013.AQSP01000134_gene1374 3.909e-47 183.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux YYD3_k127_2871438_2 448385.sce4782 1.135e-73 254.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2WJEC@28221|Deltaproteobacteria,2Z2Y8@29|Myxococcales 28221|Deltaproteobacteria JM Nucleotidyl transferase - - - - - - - - - - - - CBS,NTP_transferase YYD3_k127_2871438_0 933262.AXAM01000070_gene2280 5.331e-126 411.0 COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,43BNE@68525|delta/epsilon subdivisions,2WKIX@28221|Deltaproteobacteria,2MJ8D@213118|Desulfobacterales 28221|Deltaproteobacteria M NmrA-like family - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd YYD3_k127_2871438_4 667014.Thein_0899 5.983e-05 56.0 COG0457@1|root,COG0457@2|Bacteria,2GHED@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S ChAPs (Chs5p-Arf1p-binding proteins) - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 YYD3_k127_2871438_1 1379698.RBG1_1C00001G0549 1.106e-103 342.0 COG1137@1|root,COG1137@2|Bacteria,2NNRT@2323|unclassified Bacteria 2|Bacteria S lipopolysaccharide transport protein B ATP-binding component of ABC superfamily lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K01990,ko:K06861 ko02010,map02010 M00254,M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1,3.A.1 - - ABC_tran,BCA_ABC_TP_C YYD3_k127_288933_1 1379698.RBG1_1C00001G0158 1.381e-85 293.0 COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,2NPIU@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg YYD3_k127_288933_0 1379698.RBG1_1C00001G0157 2.145e-91 318.0 COG0642@1|root,COG2205@2|Bacteria 1379698.RBG1_1C00001G0157|- T PhoQ Sensor - - - - - - - - - - - - - YYD3_k127_288933_2 1379698.RBG1_1C00001G1550 6.058e-59 216.0 COG0285@1|root,COG0285@2|Bacteria,2NP60@2323|unclassified Bacteria 2|Bacteria H Belongs to the folylpolyglutamate synthase family folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0166,iSB619.SA_RS08370 Mur_ligase_C,Mur_ligase_M YYD3_k127_288933_4 1379698.RBG1_1C00001G1550 7.932e-26 111.0 COG0285@1|root,COG0285@2|Bacteria,2NP60@2323|unclassified Bacteria 2|Bacteria H Belongs to the folylpolyglutamate synthase family folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - iLJ478.TM0166,iSB619.SA_RS08370 Mur_ligase_C,Mur_ligase_M YYD3_k127_288933_3 1379270.AUXF01000006_gene138 1.19e-45 167.0 COG0777@1|root,COG0777@2|Bacteria,1ZSSK@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans YYD3_k127_2890379_2 290397.Adeh_0258 1.256e-12 74.0 COG4770@1|root,COG4770@2|Bacteria,1RJYU@1224|Proteobacteria,42WT6@68525|delta/epsilon subdivisions,2WSN5@28221|Deltaproteobacteria,2Z2BY@29|Myxococcales 28221|Deltaproteobacteria I Biotin-requiring enzyme - - - - - - - - - - - - Biotin_lipoyl YYD3_k127_2890379_0 96561.Dole_2179 1.512e-160 521.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2MHYZ@213118|Desulfobacterales 28221|Deltaproteobacteria I PFAM Carbamoyl-phosphate synthase L chain pccA - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 YYD3_k127_2890379_1 485913.Krac_6822 1.257e-43 163.0 COG1024@1|root,COG1024@2|Bacteria,2G7Z4@200795|Chloroflexi 200795|Chloroflexi I PFAM Enoyl-CoA hydratase isomerase - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 YYD3_k127_2904842_5 1348657.M622_01280 7.521e-05 51.0 COG3291@1|root,COG3291@2|Bacteria,1QUSE@1224|Proteobacteria 1224|Proteobacteria G PFAM FecR protein - - 3.2.1.4 ko:K01179,ko:K03933 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - AA10,CBM73,GH5,GH9 - CBM_2,Calx-beta,Cellulase,PKD YYD3_k127_2904842_3 1123503.KB908056_gene1309 1.125e-19 102.0 2941A@1|root,2ZRG3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_2904842_1 479432.Sros_1372 6.542e-25 116.0 COG0392@1|root,COG0392@2|Bacteria,2IC25@201174|Actinobacteria,4EHA8@85012|Streptosporangiales 201174|Actinobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027,ko:K20468 - - - - ko00000,ko02000 4.D.2,4.D.2.4.1 - - LPG_synthase_TM YYD3_k127_2904842_2 1382356.JQMP01000001_gene797 2.095e-22 101.0 COG1959@1|root,COG1959@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 YYD3_k127_2904842_0 552811.Dehly_1481 9.792e-43 164.0 COG3945@1|root,COG3945@2|Bacteria 2|Bacteria P hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin YYD3_k127_2904842_4 1121007.AUML01000032_gene2774 1.966e-09 58.0 COG3256@1|root,COG3256@2|Bacteria,4NG9H@976|Bacteroidetes,1HZ9Q@117743|Flavobacteriia,2YGRR@290174|Aquimarina 976|Bacteroidetes P Cytochrome C and Quinol oxidase polypeptide I - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 YYD3_k127_2907313_0 1379698.RBG1_1C00001G0159 9.188e-161 516.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_2907313_1 1379698.RBG1_1C00001G0158 1.939e-88 309.0 COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,2NPIU@2323|unclassified Bacteria 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg YYD3_k127_2911387_0 880073.Calab_2422 1.32e-129 423.0 COG1449@1|root,COG1449@2|Bacteria,2NQNB@2323|unclassified Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 57 family amyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 ko:K22451 ko00500,map00500 - R05196 RC00049 ko00000,ko00001,ko01000 - GH57 - DUF1925,DUF1926,Glyco_hydro_57 YYD3_k127_2911387_4 1191523.MROS_2558 1.782e-24 114.0 COG1463@1|root,COG1463@2|Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, periplasmic component ttg2C - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD YYD3_k127_2911387_1 1515746.HR45_18580 1.83e-61 222.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,2QA3K@267890|Shewanellaceae 1236|Gammaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022613,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0036094,GO:0042254,GO:0042274,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - iAF1260.b4161,iBWG_1329.BWG_3876,iECDH10B_1368.ECDH10B_4356,iECDH1ME8569_1439.ECDH1ME8569_4021,iEKO11_1354.EKO11_4148,iEcDH1_1363.EcDH1_3829,iEcolC_1368.EcolC_3849,iJO1366.b4161,iUMNK88_1353.UMNK88_5099,iY75_1357.Y75_RS21675 RsgA_GTPase YYD3_k127_2911387_2 1237149.C900_00817 5.04e-34 136.0 COG2318@1|root,COG2318@2|Bacteria,4NSE5@976|Bacteroidetes,47S2U@768503|Cytophagia 976|Bacteroidetes S DinB family - - - - - - - - - - - - DinB YYD3_k127_2911387_3 880073.Calab_0214 5.22e-25 106.0 COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW YYD3_k127_2915647_1 1379698.RBG1_1C00001G0535 5.812e-66 235.0 COG0266@1|root,COG0266@2|Bacteria,2NPGY@2323|unclassified Bacteria 2|Bacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS YYD3_k127_2915647_0 1379698.RBG1_1C00001G0182 5.475e-75 263.0 COG0340@1|root,COG0340@2|Bacteria,2NPG2@2323|unclassified Bacteria 2|Bacteria H biotin acetyl-CoA-carboxylase ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 YYD3_k127_2916667_0 1379698.RBG1_1C00001G0520 6.82e-86 299.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 - - - CHASE2,GAF,GAF_2,HATPase_c_2,SpoIIE YYD3_k127_2916667_2 272123.Anacy_3419 7.287e-05 54.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - 3.1.3.1,3.1.3.8,3.1.4.46 ko:K01077,ko:K01083,ko:K01126 ko00562,ko00564,ko00730,ko00790,ko01100,ko02020,map00562,map00564,map00730,map00790,map01100,map02020 M00126 R01030,R01470,R02135,R03371,R04620 RC00017,RC00078,RC00425 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Cadherin,DUF4114,DUF4347,HemolysinCabind,PA14,Phytase-like YYD3_k127_2916667_1 498211.CJA_1292 3.264e-33 141.0 COG2374@1|root,COG3391@1|root,COG5184@1|root,COG2374@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria 2|Bacteria DZ guanyl-nucleotide exchange factor activity mtsC - - - - - - - - - - - Big_5,CHU_C,LTD,Reprolysin_4,SLH,TSP_3 YYD3_k127_293166_2 871963.Desdi_0929 5.92e-34 132.0 COG0586@1|root,COG0586@2|Bacteria,1UZ4P@1239|Firmicutes,24FU4@186801|Clostridia,261J4@186807|Peptococcaceae 186801|Clostridia S PFAM SNARE associated Golgi protein dedA - - ko:K03975 - - - - ko00000 - - - SNARE_assoc YYD3_k127_293166_5 443144.GM21_1416 6.756e-06 54.0 COG1633@1|root,COG1633@2|Bacteria,1NG4N@1224|Proteobacteria,42W3T@68525|delta/epsilon subdivisions,2WSZ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD3_k127_293166_0 1379698.RBG1_1C00001G1529 1.114e-50 202.0 COG2304@1|root,COG2304@2|Bacteria,2NPUS@2323|unclassified Bacteria 2|Bacteria S IgA Peptidase M64 - - - - - - - - - - - - M64_N,Peptidase_M64 YYD3_k127_293166_1 448385.sce6661 9.233e-40 172.0 COG1520@1|root,COG2374@1|root,COG5184@1|root,COG1520@2|Bacteria,COG2374@2|Bacteria,COG5184@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria 1224|Proteobacteria DZ Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 YYD3_k127_293166_4 215803.DB30_7958 2.916e-20 108.0 COG3391@1|root,COG3391@2|Bacteria,1P80Y@1224|Proteobacteria,43959@68525|delta/epsilon subdivisions,2X4BM@28221|Deltaproteobacteria,2YYPB@29|Myxococcales 1224|Proteobacteria S amine dehydrogenase activity - - - - - - - - - - - - - YYD3_k127_293166_3 1122179.KB890425_gene3428 1.277e-20 109.0 COG1404@1|root,COG2356@1|root,COG3291@1|root,COG1404@2|Bacteria,COG2356@2|Bacteria,COG3291@2|Bacteria,4PPF8@976|Bacteroidetes 976|Bacteroidetes O Reprolysin (M12B) family zinc metalloprotease - - - - - - - - - - - - Reprolysin_5 YYD3_k127_294421_1 857293.CAAU_1723 1.57e-102 348.0 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,36E1K@31979|Clostridiaceae 186801|Clostridia J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 YYD3_k127_294421_2 1379698.RBG1_1C00001G0868 1.234e-58 210.0 COG0741@1|root,COG0741@2|Bacteria,2NPKN@2323|unclassified Bacteria 2|Bacteria M Transglycosylase SLT domain slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,TPR_16,TPR_6 YYD3_k127_294421_4 1379698.RBG1_1C00001G0869 1.585e-32 138.0 COG4105@1|root,COG4105@2|Bacteria,2NPZ3@2323|unclassified Bacteria 2|Bacteria S Outer membrane lipoprotein yfiO - - ko:K05807,ko:K08309 - - - - ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 - YfiO YYD3_k127_294421_3 1210884.HG799463_gene9385 1.714e-35 143.0 COG1057@1|root,COG1057@2|Bacteria,2IZMU@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like YYD3_k127_294421_0 1379698.RBG1_1C00001G0871 9.884e-308 968.0 COG0749@1|root,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria 2|Bacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 YYD3_k127_294421_5 1536772.R70723_10700 1.211e-29 126.0 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,26WY5@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08510 CoaE YYD3_k127_294421_6 429009.Adeg_0433 1.713e-23 108.0 COG0791@1|root,COG3807@1|root,COG0791@2|Bacteria,COG3807@2|Bacteria,1TSZ0@1239|Firmicutes,25B8W@186801|Clostridia,42J9X@68295|Thermoanaerobacterales 186801|Clostridia M NlpC/P60 family - - 3.4.14.13 ko:K20742 - - - - ko00000,ko01000,ko01002 - - - NLPC_P60,SH3_3,SH3_4 YYD3_k127_2950529_3 1121396.KB893001_gene3951 3.676e-20 104.0 COG2067@1|root,COG2067@2|Bacteria,1NHG3@1224|Proteobacteria 1224|Proteobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X YYD3_k127_2950529_5 945713.IALB_0805 9.534e-15 83.0 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization CP_0079 - - ko:K15368 - - - - ko00000 - - - TPR_16,TPR_21,TPR_6 YYD3_k127_2950529_0 1123376.AUIU01000014_gene636 1.141e-167 554.0 COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae 40117|Nitrospirae G Glycosyl hydrolase family 57 - - - - - - - - - - - - Glyco_hydro_57 YYD3_k127_2950529_1 1379698.RBG1_1C00001G0405 3.456e-62 224.0 COG4784@1|root,COG4784@2|Bacteria,2NS4E@2323|unclassified Bacteria 2|Bacteria S Peptidase family M48 MA20_40030 - - - - - - - - - - - LysM,Peptidase_M48 YYD3_k127_2950529_6 1392490.JHZX01000001_gene163 4.204e-12 77.0 COG2067@1|root,COG2067@2|Bacteria,4NHNC@976|Bacteroidetes,1HZFD@117743|Flavobacteriia 976|Bacteroidetes I penicillin-binding protein porQ - - - - - - - - - - - PorP_SprF YYD3_k127_2950529_2 1191523.MROS_0297 5.374e-59 216.0 COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria 2|Bacteria M undecaprenyl-phosphate glucose phosphotransferase activity wcaJ GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046402,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.187,2.7.8.40 ko:K05946,ko:K21303 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - GT26 - Bac_transf,CoA_binding_3 YYD3_k127_2950529_7 246969.TAM4_499 5.522e-06 55.0 COG0515@1|root,arCOG00372@1|root,arCOG03264@1|root,arCOG00372@2157|Archaea,arCOG03264@2157|Archaea,arCOG03682@2157|Archaea,2XWYZ@28890|Euryarchaeota,2437Z@183968|Thermococci 183968|Thermococci T Protein tyrosine kinase - - - - - - - - - - - - Pkinase YYD3_k127_2982704_0 1379698.RBG1_1C00001G0247 6.168e-68 243.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity - - - - - - - - - - - - SpoIIE YYD3_k127_2982704_1 240015.ACP_0849 1.476e-65 235.0 COG0702@1|root,COG0702@2|Bacteria,3Y644@57723|Acidobacteria,2JKJ0@204432|Acidobacteriia 204432|Acidobacteriia GM NmrA-like family - - - - - - - - - - - - NmrA YYD3_k127_2982704_2 1303518.CCALI_02842 1.76e-20 93.0 COG0074@1|root,COG0074@2|Bacteria 2|Bacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0001539,GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016020,GO:0016310,GO:0016874,GO:0016877,GO:0016878,GO:0019538,GO:0030312,GO:0031974,GO:0032991,GO:0036211,GO:0040007,GO:0040011,GO:0042709,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0046777,GO:0048870,GO:0051179,GO:0051674,GO:0070013,GO:0071704,GO:0071944,GO:0071973,GO:0097588,GO:1901564,GO:1902494 6.2.1.5,6.2.1.9 ko:K01902,ko:K02381,ko:K08692 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_0608,iYO844.BSU16100 CoA_binding,DUF1116,Ligase_CoA YYD3_k127_2984314_1 575540.Isop_2819 1.592e-18 90.0 COG2804@1|root,COG2804@2|Bacteria,2IXSA@203682|Planctomycetes 203682|Planctomycetes NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N YYD3_k127_2984314_0 760142.Hipma_1131 3.598e-72 259.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2M7KS@213113|Desulfurellales 28221|Deltaproteobacteria NU Type II secretion system (T2SS), protein F - - - ko:K02653,ko:K12278 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF YYD3_k127_2984314_2 909663.KI867151_gene3115 5.743e-11 69.0 COG4969@1|root,COG4969@2|Bacteria,1QZMY@1224|Proteobacteria,43D4G@68525|delta/epsilon subdivisions 1224|Proteobacteria NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl YYD3_k127_2984314_4 596151.DesfrDRAFT_3563 1.349e-05 55.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,2MBZA@213115|Desulfovibrionales 28221|Deltaproteobacteria U PFAM type II secretion system protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG YYD3_k127_2984314_3 1242864.D187_006599 3.439e-09 68.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2YUJQ@29|Myxococcales 28221|Deltaproteobacteria NU pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 YYD3_k127_3027307_8 246194.CHY_0288 6.683e-17 83.0 COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,42G0N@68295|Thermoanaerobacterales 186801|Clostridia S PFAM metal-dependent phosphohydrolase, HD sub domain - - - ko:K06951 - - - - ko00000 - - - HD YYD3_k127_3027307_9 1229520.ADIAL_1109 2.232e-07 60.0 COG4720@1|root,COG4720@2|Bacteria,1V5GD@1239|Firmicutes,4HI8Y@91061|Bacilli,27GCZ@186828|Carnobacteriaceae 91061|Bacilli S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ECF_trnsprt YYD3_k127_3027307_4 1379698.RBG1_1C00001G1245 1.86e-61 237.0 COG1629@1|root,COG4771@2|Bacteria,2NRGW@2323|unclassified Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarboxypepD_reg,TonB_dep_Rec YYD3_k127_3027307_5 1379698.RBG1_1C00001G1246 5.196e-61 220.0 COG0613@1|root,COG0613@2|Bacteria,2NPEX@2323|unclassified Bacteria 2|Bacteria S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP YYD3_k127_3027307_0 1379698.RBG1_1C00001G1247 2.174e-160 521.0 COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria 2|Bacteria E Formiminotransferase-cyclodeaminase ftcD - 2.1.2.5,4.3.1.4 ko:K00603,ko:K01746,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 - - - FTCD,FTCD_C,FTCD_N YYD3_k127_3027307_2 1379698.RBG1_1C00001G1248 9.009e-90 306.0 COG1899@1|root,COG1899@2|Bacteria,2NP1S@2323|unclassified Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - YYD3_k127_3027307_3 1379698.RBG1_1C00001G1249 1.143e-71 251.0 COG3170@1|root,COG3170@2|Bacteria,2NPQF@2323|unclassified Bacteria 2|Bacteria NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 YYD3_k127_3027307_6 935948.KE386494_gene822 3.277e-31 128.0 COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia,42GVA@68295|Thermoanaerobacterales 186801|Clostridia T PFAM Protein-tyrosine phosphatase, low molecular weight ywlE - 3.1.3.48,3.9.1.2 ko:K01104,ko:K20201 - - - - ko00000,ko01000 - - - LMWPc YYD3_k127_3027307_7 589924.Ferp_0857 1.974e-26 117.0 COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,245ZQ@183980|Archaeoglobi 183980|Archaeoglobi J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC YYD3_k127_3027307_1 1379698.RBG1_1C00001G1252 2.453e-120 396.0 COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria 2|Bacteria M Mannose-6-phosphate isomerase manC - 2.7.7.13,5.3.1.8,5.4.2.8 ko:K00971,ko:K01840,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01818,R01819 RC00002,RC00376,RC00408 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS00940 MannoseP_isomer,NTP_transferase YYD3_k127_3034167_4 468059.AUHA01000008_gene2750 3.313e-74 255.0 COG0113@1|root,COG0113@2|Bacteria,4NFW6@976|Bacteroidetes,1INPZ@117747|Sphingobacteriia 976|Bacteroidetes H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD YYD3_k127_3034167_0 1229276.DI53_2263 3.879e-151 489.0 COG0001@1|root,COG0001@2|Bacteria,4NDXG@976|Bacteroidetes,1INWD@117747|Sphingobacteriia 976|Bacteroidetes H Glutamate-1-semialdehyde aminotransferase hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 YYD3_k127_3034167_3 653733.Selin_2337 5.363e-83 287.0 COG0407@1|root,COG0407@2|Bacteria 2|Bacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0016 URO-D YYD3_k127_3034167_1 404589.Anae109_1129 5.546e-127 421.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2WMB0@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN - - - - - - - - - - - HemN_C,Radical_SAM YYD3_k127_3034167_5 1232410.KI421415_gene3101 3.928e-70 252.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,43RXT@69541|Desulfuromonadales 28221|Deltaproteobacteria H Ferrochelatase hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase YYD3_k127_3034167_2 243231.GSU0012 9.741e-119 396.0 COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,43SUB@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase YYD3_k127_3035557_1 634176.NT05HA_0414 4.851e-118 394.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1Y9NE@135625|Pasteurellales 135625|Pasteurellales M Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept YYD3_k127_3035557_0 471854.Dfer_3807 1.325e-128 417.0 COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,47JZ2@768503|Cytophagia 976|Bacteroidetes C TIGRFAM delta-1-pyrroline-5-carboxylate dehydrogenase, group 1 pruA - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh YYD3_k127_3046720_0 1379698.RBG1_1C00001G0287 6.161e-141 464.0 COG4191@1|root,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9 YYD3_k127_3046720_1 1379698.RBG1_1C00001G0286 1.141e-50 207.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria 1379698.RBG1_1C00001G0286|- KLT protein kinase activity - - - - - - - - - - - - - YYD3_k127_3046720_2 1379698.RBG1_1C00001G0175 3.807e-21 99.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,2NRE7@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02022,ko:K16922,ko:K20345 ko02024,map02024 - - - ko00000,ko00001,ko01002,ko02000 3.A.1.112,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,PqqD YYD3_k127_3056976_1 118161.KB235922_gene999 9.167e-29 118.0 COG3033@1|root,COG3033@2|Bacteria,1G33V@1117|Cyanobacteria 1117|Cyanobacteria E Beta-eliminating lyase - - - - - - - - - - - - Beta_elim_lyase YYD3_k127_3056976_2 1115512.EH105704_01_03870 0.0001926 51.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,3XMD1@561|Escherichia 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis protein II tar GO:0001101,GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006935,GO:0007154,GO:0007165,GO:0007172,GO:0008150,GO:0009593,GO:0009605,GO:0009719,GO:0009893,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010604,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032101,GO:0032268,GO:0032270,GO:0032991,GO:0034622,GO:0038023,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0043200,GO:0043424,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051606,GO:0051716,GO:0060089,GO:0060255,GO:0065003,GO:0065007,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0071944,GO:0080090,GO:0098561,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901873,GO:1901875 - ko:K03406,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,TarH YYD3_k127_3056976_0 1379698.RBG1_1C00001G1789 4.764e-154 521.0 COG1572@1|root,COG1572@2|Bacteria,2NP03@2323|unclassified Bacteria 2|Bacteria S Propeptide_C25 porU - - - - - - - - - - - Peptidase_C25 YYD3_k127_3066354_4 1379698.RBG1_1C00001G0435 9.641e-24 111.0 COG1747@1|root,COG1747@2|Bacteria,2NP33@2323|unclassified Bacteria 2|Bacteria M methyltransferase greA - - - - - - - - - - - GreA_GreB,GreA_GreB_N,SprA_N YYD3_k127_3066354_2 886293.Sinac_7127 2.324e-31 134.0 COG0823@1|root,COG0823@2|Bacteria,2IZKS@203682|Planctomycetes 203682|Planctomycetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 YYD3_k127_3066354_3 1101195.Meth11DRAFT_2257 7.033e-26 109.0 COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,2VV31@28216|Betaproteobacteria,2KN8M@206350|Nitrosomonadales 206350|Nitrosomonadales P Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 YYD3_k127_3066354_0 880073.Calab_3241 1.439e-182 583.0 COG0439@1|root,COG0439@2|Bacteria,2NNWM@2323|unclassified Bacteria 2|Bacteria I acetyl-CoA carboxylase, biotin carboxylase accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 YYD3_k127_3066354_1 1220551.SCHR_01445 3.762e-46 169.0 COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,4GZ53@90964|Staphylococcaceae 91061|Bacilli E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H YYD3_k127_3066354_5 1128398.Curi_c00760 1.482e-11 66.0 COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,268QF@186813|unclassified Clostridiales 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P YYD3_k127_3096078_0 926550.CLDAP_26360 2.209e-81 290.0 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2G7I4@200795|Chloroflexi 200795|Chloroflexi UW Hep Hag repeat protein - - - - - - - - - - - - - YYD3_k127_3096078_1 204669.Acid345_2109 8.063e-48 187.0 COG5295@1|root,COG5295@2|Bacteria,3Y72W@57723|Acidobacteria,2JM9T@204432|Acidobacteriia 2|Bacteria UW Hep Hag repeat protein yeeJ - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF5122,Peptidase_S74,YadA_head,YadA_stalk YYD3_k127_3096078_4 1379698.RBG1_1C00001G0282 4.977e-16 91.0 COG5276@1|root,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,LVIVD YYD3_k127_3096078_5 1267534.KB906757_gene857 3.318e-15 87.0 COG2931@1|root,COG2931@2|Bacteria 2|Bacteria Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - DUF4347,Lactonase,Laminin_G_3,VCBS,VPEP YYD3_k127_3096078_3 926569.ANT_31340 1.374e-29 122.0 COG0724@1|root,COG0724@2|Bacteria,2G74A@200795|Chloroflexi 200795|Chloroflexi S PFAM RNP-1 like RNA-binding protein - - - - - - - - - - - - RRM_1 YYD3_k127_3096078_2 243090.RB10458 2.352e-30 123.0 COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes 203682|Planctomycetes S PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - - - - - - - - - - RRM_1 YYD3_k127_3096078_8 679935.Alfi_3118 0.0002043 53.0 COG4206@1|root,COG4206@2|Bacteria,4PM6D@976|Bacteroidetes,2G0X7@200643|Bacteroidia,22VBY@171550|Rikenellaceae 976|Bacteroidetes H TonB-dependent Receptor Plug Domain - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD3_k127_3104676_1 635013.TherJR_2349 4.53e-132 431.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,2607Y@186807|Peptococcaceae 186801|Clostridia F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA2 - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK YYD3_k127_3104676_2 338963.Pcar_0641 3.031e-93 316.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox YYD3_k127_3104676_3 743719.PaelaDRAFT_3368 9.966e-55 201.0 COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,4HEGP@91061|Bacilli,26TNF@186822|Paenibacillaceae 91061|Bacilli C NAD(P)H-dependent oxidoreductase nfrA - 1.5.1.38 ko:K19285 ko00740,ko01100,map00740,map01100 - R05706 RC00126 ko00000,ko00001,ko01000 - - - Nitroreductase YYD3_k127_3104676_0 251221.35211292 6.882e-218 706.0 COG5549@1|root,COG5549@2|Bacteria,1G2AK@1117|Cyanobacteria 1117|Cyanobacteria O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 YYD3_k127_3104676_4 483219.LILAB_22105 1.492e-07 64.0 COG3227@1|root,COG4733@1|root,COG3227@2|Bacteria,COG4733@2|Bacteria,1NNV4@1224|Proteobacteria,42Q3S@68525|delta/epsilon subdivisions,2WMM2@28221|Deltaproteobacteria,2Z1Q8@29|Myxococcales 28221|Deltaproteobacteria E cellulase activity - - - - - - - - - - - - - YYD3_k127_313465_3 661478.OP10G_2391 8.253e-35 145.0 COG1409@1|root,COG3669@1|root,COG1409@2|Bacteria,COG3669@2|Bacteria 2|Bacteria G Alpha-L-fucosidase - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C,PA14 YYD3_k127_313465_1 929556.Solca_1648 2.729e-167 547.0 COG0265@1|root,COG0265@2|Bacteria,4PNUK@976|Bacteroidetes,1IRYS@117747|Sphingobacteriia 976|Bacteroidetes O Peptide-N-glycosidase F, C terminal - - - - - - - - - - - - Laminin_G_3,N-glycanase_C YYD3_k127_313465_4 223283.PSPTO_4335 3.851e-08 60.0 2ATRU@1|root,31JAM@2|Bacteria,1QH20@1224|Proteobacteria,1TEJU@1236|Gammaproteobacteria,1Z7TF@136849|Pseudomonas syringae group 1236|Gammaproteobacteria - - - - - - - - - - - - - - PilZ YYD3_k127_313465_0 1379698.RBG1_1C00001G1562 1.05e-220 705.0 COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria 2|Bacteria M Transglycosylase mrcA GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase YYD3_k127_313465_2 945713.IALB_1745 7.743e-128 421.0 COG0162@1|root,COG0162@2|Bacteria 2|Bacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436,iLJ478.TM0478 S4,tRNA-synt_1b YYD3_k127_3199575_3 1408428.JNJP01000024_gene3775 9.456e-71 245.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria,2M883@213115|Desulfovibrionales 28221|Deltaproteobacteria KO Hydrogenase accessory protein HypB hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW YYD3_k127_3199575_0 880073.Calab_2999 4.772e-227 726.0 COG0068@1|root,COG0068@2|Bacteria,2NNRA@2323|unclassified Bacteria 2|Bacteria O Belongs to the carbamoyltransferase HypF family hypF GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016740,GO:0016741,GO:0016743,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0046944,GO:0051604,GO:0071704,GO:1901564 - ko:K04653,ko:K04656 - - - - ko00000 - - iAF987.Gmet_0119 Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF YYD3_k127_3199575_4 517418.Ctha_1825 7.406e-23 101.0 COG0298@1|root,COG0298@2|Bacteria,1FE7S@1090|Chlorobi 1090|Chlorobi O PFAM hydrogenase expression formation protein (HUPF HYPC) - - - ko:K04653 - - - - ko00000 - - - HupF_HypC YYD3_k127_3199575_1 517418.Ctha_1826 3.001e-171 543.0 COG0409@1|root,COG0409@2|Bacteria,1FD8B@1090|Chlorobi 1090|Chlorobi O hydrogenase expression formation protein HypD - - - ko:K04654 - - - - ko00000 - - - HypD YYD3_k127_3199575_2 240015.ACP_3058 9.1e-87 294.0 COG0309@1|root,COG0309@2|Bacteria,3Y3UH@57723|Acidobacteria,2JK96@204432|Acidobacteriia 204432|Acidobacteriia O AIR synthase related protein, C-terminal domain - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C YYD3_k127_3235389_0 404589.Anae109_1549 1.643e-130 445.0 COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales 28221|Deltaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10,TPR_12 YYD3_k127_3235389_1 404589.Anae109_3826 7.828e-05 46.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2WJF5@28221|Deltaproteobacteria 28221|Deltaproteobacteria T CBS domain containing protein - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding YYD3_k127_3252854_3 706587.Desti_3288 5.131e-05 46.0 COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,2MRSU@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase iorB-1 - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR YYD3_k127_3252854_0 1031288.AXAA01000002_gene1383 6.66e-105 352.0 COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae 186801|Clostridia C Belongs to the acetokinase family buk GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase YYD3_k127_3252854_1 857293.CAAU_0252 1.405e-60 222.0 COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,36DC6@31979|Clostridiaceae 186801|Clostridia C phosphate butyryltransferase - - 2.3.1.19 ko:K00634 ko00650,ko01100,map00650,map01100 - R01174 RC00004,RC02816 ko00000,ko00001,ko01000 - - - PTA_PTB YYD3_k127_3252854_2 401526.TcarDRAFT_0365 2.668e-56 208.0 COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,4H2DY@909932|Negativicutes 909932|Negativicutes C Phosphate acetyl/butaryl transferase - - - - - - - - - - - - PTA_PTB YYD3_k127_3314414_3 945713.IALB_1169 5.23e-14 77.0 COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD3_k127_3314414_1 1379698.RBG1_1C00001G1821 2.022e-25 116.0 COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria 2|Bacteria H Biotin/lipoate A/B protein ligase family lipM GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB YYD3_k127_3314414_0 1379698.RBG1_1C00001G0933 5.206e-88 318.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02584,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022,ko03000 - - - FHA,GAF,GAF_2,HTH_8,Sigma54_activat YYD3_k127_3314414_2 1379698.RBG1_1C00001G0933 1.174e-19 97.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02584,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022,ko03000 - - - FHA,GAF,GAF_2,HTH_8,Sigma54_activat YYD3_k127_3314414_4 697284.ERIC2_c22570 2.173e-11 66.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,4H9SB@91061|Bacilli,26QIQ@186822|Paenibacillaceae 91061|Bacilli S Hemolysins and related proteins containing CBS domains corC3 - - - - - - - - - - - CBS,CorC_HlyC,DUF21 YYD3_k127_3332989_0 1321778.HMPREF1982_00984 2.506e-314 981.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,267M9@186813|unclassified Clostridiales 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran YYD3_k127_3332989_1 926550.CLDAP_23690 3.028e-32 130.0 COG1765@1|root,COG1765@2|Bacteria,2G6Y1@200795|Chloroflexi 200795|Chloroflexi O PFAM OsmC family protein - - - ko:K07397 - - - - ko00000 - - - OsmC YYD3_k127_3332989_2 768706.Desor_5062 7.888e-32 128.0 COG3439@1|root,COG3439@2|Bacteria,1VA5R@1239|Firmicutes,24NQI@186801|Clostridia 186801|Clostridia S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 YYD3_k127_3332989_3 309799.DICTH_1607 7.276e-11 64.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 YYD3_k127_3332989_4 395495.Lcho_1296 4.886e-06 48.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,1KJ0K@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefC - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N YYD3_k127_3334843_2 1123405.AUMM01000005_gene881 4.429e-21 102.0 COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,4H9Q8@91061|Bacilli,26NKI@186821|Sporolactobacillaceae 91061|Bacilli O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N YYD3_k127_3334843_0 1158318.ATXC01000001_gene1441 6.938e-88 295.0 COG0740@1|root,COG0740@2|Bacteria,2G3IM@200783|Aquificae 200783|Aquificae O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease YYD3_k127_3334843_1 1262449.CP6013_1832 6.442e-58 205.0 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,36EA3@31979|Clostridiaceae 186801|Clostridia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX YYD3_k127_3335284_2 388413.ALPR1_12685 1.352e-05 56.0 COG0457@1|root,COG0457@2|Bacteria,4PBMY@976|Bacteroidetes,47W2P@768503|Cytophagia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 YYD3_k127_3335284_1 1249480.B649_09540 1.837e-27 119.0 COG1858@1|root,COG1858@2|Bacteria 2|Bacteria C electron transfer activity - - - - - - - - - - - - CCP_MauG,Cytochrom_C,Cytochrom_D1,DHOR,Lactonase,RicinB_lectin_2 YYD3_k127_3335284_0 1009370.ALO_18817 9.185e-83 283.0 COG2103@1|root,COG2103@2|Bacteria,1TPSF@1239|Firmicutes,4H28B@909932|Negativicutes 909932|Negativicutes G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 YYD3_k127_3337392_1 1379698.RBG1_1C00001G0881 5.254e-53 192.0 COG0860@1|root,COG0860@2|Bacteria,2NQ79@2323|unclassified Bacteria 2|Bacteria M Ami_3 amiA - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,GHL10,SpoIID YYD3_k127_3337392_0 1379698.RBG1_1C00001G0669 1.237e-56 206.0 COG3064@1|root,COG3064@2|Bacteria 2|Bacteria M translation initiation factor activity - - - ko:K03699 - - - - ko00000,ko02042 - - - Peptidase_M56 YYD3_k127_3337392_2 404589.Anae109_0401 2.823e-32 129.0 COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,43765@68525|delta/epsilon subdivisions,2X24N@28221|Deltaproteobacteria,2YW4N@29|Myxococcales 28221|Deltaproteobacteria H pterin-4-alpha-carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a YYD3_k127_3337392_3 439235.Dalk_0558 9.53e-15 79.0 2EDE2@1|root,337AD@2|Bacteria,1NA2N@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - YYD3_k127_3362482_8 85643.Tmz1t_0841 4.02e-21 98.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,2KVNM@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the dGTPase family. Type 2 subfamily dgt1 - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc YYD3_k127_3362482_0 1519464.HY22_10360 2.787e-215 682.0 COG0154@1|root,COG0154@2|Bacteria,1FDMC@1090|Chlorobi 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase YYD3_k127_3362482_1 1519464.HY22_10360 1.744e-189 612.0 COG0154@1|root,COG0154@2|Bacteria,1FDMC@1090|Chlorobi 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase YYD3_k127_3362482_2 880073.Calab_1912 4.55e-73 254.0 COG2518@1|root,COG2518@2|Bacteria,2NP7E@2323|unclassified Bacteria 2|Bacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT YYD3_k127_3362482_6 861299.J421_0909 1.003e-48 181.0 COG2940@1|root,COG2940@2|Bacteria,1ZTR3@142182|Gemmatimonadetes 142182|Gemmatimonadetes S SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - ko:K07117 - - - - ko00000 - - - SET YYD3_k127_3362482_5 566466.NOR53_1056 4.265e-49 184.0 COG1385@1|root,COG1385@2|Bacteria,1NSD3@1224|Proteobacteria,1SKC3@1236|Gammaproteobacteria,1J7U7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - - - - - - - - - - - Methyltrans_RNA YYD3_k127_3362482_4 304371.MCP_2273 2.121e-50 195.0 arCOG00787@1|root,arCOG00787@2157|Archaea 2157|Archaea L UvrD REP helicase - - 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C YYD3_k127_3362482_3 935863.AWZR01000003_gene2845 8.277e-63 231.0 COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,1RPB8@1236|Gammaproteobacteria,1X7Y9@135614|Xanthomonadales 135614|Xanthomonadales M Glycosyl transferases group 1 - - - ko:K21001 ko02025,map02025 - - - ko00000,ko00001,ko01003 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4 YYD3_k127_3362482_7 338969.Rfer_0675 1.256e-27 123.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2VTTG@28216|Betaproteobacteria,4AFS5@80864|Comamonadaceae 28216|Betaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 YYD3_k127_3363288_10 765869.BDW_12585 4.105e-07 60.0 COG3334@1|root,COG3334@2|Bacteria,1PT17@1224|Proteobacteria,437BU@68525|delta/epsilon subdivisions,2MTDP@213481|Bdellovibrionales,2X2H9@28221|Deltaproteobacteria 213481|Bdellovibrionales S PFAM MgtE intracellular - - - - - - - - - - - - - YYD3_k127_3363288_11 926692.AZYG01000007_gene1314 6.942e-06 59.0 COG3144@1|root,COG3144@2|Bacteria,1VAP1@1239|Firmicutes,24UIZ@186801|Clostridia 186801|Clostridia N PFAM flagellar hook-length control - - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook YYD3_k127_3363288_5 573370.DMR_13740 5.379e-37 148.0 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,42U4T@68525|delta/epsilon subdivisions,2WQ5B@28221|Deltaproteobacteria,2MBHG@213115|Desulfovibrionales 28221|Deltaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig YYD3_k127_3363288_8 555088.DealDRAFT_2634 9.043e-17 86.0 2E35U@1|root,32Y5R@2|Bacteria,1VEH9@1239|Firmicutes,24R2S@186801|Clostridia,42K51@68298|Syntrophomonadaceae 186801|Clostridia N Pfam:DUF3766 flg - - - - - - - - - - - Flagellar_put YYD3_k127_3363288_0 1313304.CALK_1067 1.187e-93 332.0 COG1749@1|root,COG1749@2|Bacteria 2|Bacteria N bacterial-type flagellum-dependent cell motility flgE GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - DUF3370,FlaE,Flg_bb_rod,Flg_bbr_C YYD3_k127_3363288_9 273068.TTE1432 2.225e-16 80.0 COG1582@1|root,COG1582@2|Bacteria,1VKHB@1239|Firmicutes,24RWI@186801|Clostridia,42H8U@68295|Thermoanaerobacterales 186801|Clostridia N PFAM flagellar flbD - - ko:K02385 - - - - ko00000,ko02035 - - - FlbD YYD3_k127_3363288_12 862908.BMS_0555 4.794e-05 53.0 COG1580@1|root,COG1580@2|Bacteria,1NBUX@1224|Proteobacteria,42RSV@68525|delta/epsilon subdivisions,2MTD5@213481|Bdellovibrionales,2WR7K@28221|Deltaproteobacteria 213481|Bdellovibrionales N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL YYD3_k127_3363288_3 243276.TPANIC_0721 1.432e-71 253.0 COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes 203691|Spirochaetes N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C YYD3_k127_3363288_6 1121936.AUHI01000004_gene1579 1.446e-30 128.0 COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,4HC56@91061|Bacilli 91061|Bacilli N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliY GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032879,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1902021,GO:2000145 - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - CheC,FliMN_C YYD3_k127_3363288_13 264462.Bd3326 0.0005068 49.0 COG3190@1|root,COG3190@2|Bacteria,1NHJX@1224|Proteobacteria,437MR@68525|delta/epsilon subdivisions,2MU5D@213481|Bdellovibrionales,2X2VV@28221|Deltaproteobacteria 213481|Bdellovibrionales N Polar flagellar assembly protein FliO - - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO YYD3_k127_3363288_2 243231.GSU0423 4.717e-88 297.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,42NDZ@68525|delta/epsilon subdivisions,2WKCN@28221|Deltaproteobacteria,43UJF@69541|Desulfuromonadales 28221|Deltaproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP YYD3_k127_3363288_7 1123367.C666_05760 1.27e-23 102.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,2VU8S@28216|Betaproteobacteria,2KX39@206389|Rhodocyclales 206389|Rhodocyclales N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 YYD3_k127_3363288_4 1120985.AUMI01000015_gene1680 8.702e-40 158.0 COG1684@1|root,COG1684@2|Bacteria,1TRB2@1239|Firmicutes,4H3BC@909932|Negativicutes 909932|Negativicutes N flagellar biosynthetic protein FliR fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 YYD3_k127_3363288_1 1117108.PAALTS15_26539 3.286e-91 311.0 COG1377@1|root,COG1377@2|Bacteria,1TPRP@1239|Firmicutes,4HB7Y@91061|Bacilli,26TRR@186822|Paenibacillaceae 91061|Bacilli N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 YYD3_k127_336812_1 1168034.FH5T_08145 5.214e-06 60.0 COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,2FQRG@200643|Bacteroidia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - Peptidase_S8 YYD3_k127_336812_0 1379698.RBG1_1C00001G0400 3.825e-34 140.0 COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria 2|Bacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin YYD3_k127_3370141_4 1379698.RBG1_1C00001G1004 6.766e-58 205.0 COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria 2|Bacteria D Peptidoglycan polymerase that is essential for cell wall elongation rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE YYD3_k127_3370141_6 1216967.L100_11168 1.522e-13 83.0 COG0793@1|root,COG0793@2|Bacteria,4NEF4@976|Bacteroidetes,1HZ1M@117743|Flavobacteriia,34Q36@308865|Elizabethkingia 976|Bacteroidetes M Aspartyl protease - - - - - - - - - - - - Asp_protease_2,PDZ,PDZ_2 YYD3_k127_3370141_2 1379698.RBG1_1C00001G1008 1.755e-126 413.0 COG0205@1|root,COG0205@2|Bacteria,2NNY2@2323|unclassified Bacteria 2|Bacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK YYD3_k127_3370141_7 78245.Xaut_2468 0.0007951 50.0 COG3637@1|root,COG3637@2|Bacteria,1RKNU@1224|Proteobacteria,2U7U5@28211|Alphaproteobacteria,3EZJK@335928|Xanthobacteraceae 28211|Alphaproteobacteria M PFAM porin - - - ko:K16079 - - - - ko00000,ko02000 1.B.4.2.1 - - OMP_b-brl YYD3_k127_3370141_1 351607.Acel_1114 2.07e-134 435.0 COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4ES5V@85013|Frankiales 201174|Actinobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N YYD3_k127_3370141_0 945713.IALB_1271 7.732e-162 518.0 COG0126@1|root,COG0126@2|Bacteria 2|Bacteria F phosphoglycerate kinase activity pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK YYD3_k127_3370141_3 883126.HMPREF9710_02236 1.978e-82 280.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,4726Q@75682|Oxalobacteraceae 28216|Betaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM YYD3_k127_3370141_5 1379698.RBG1_1C00001G1012 1.071e-16 84.0 COG1314@1|root,COG1314@2|Bacteria,2NQ7S@2323|unclassified Bacteria 2|Bacteria U Preprotein translocase SecG subunit secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG YYD3_k127_3374690_1 1379698.RBG1_1C00001G1236 2.071e-62 225.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - - ko:K06882 - - - - ko00000 - - - fn3 YYD3_k127_3374690_0 411464.DESPIG_02784 3.233e-120 400.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_3374690_2 525904.Tter_1564 5.343e-13 76.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides ina - - ko:K09607 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M6 YYD3_k127_341392_6 316067.Geob_1823 1.122e-14 78.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,43TKB@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_341392_3 929556.Solca_3116 6.263e-99 346.0 COG1835@1|root,COG1835@2|Bacteria,4NMNZ@976|Bacteroidetes,1IQXU@117747|Sphingobacteriia 976|Bacteroidetes I Domain of unknown function (DUF4153) - - - - - - - - - - - - DUF4153 YYD3_k127_341392_1 869210.Marky_1927 1.196e-184 590.0 COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E COG0076 Glutamate decarboxylase and related PLP-dependent - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC YYD3_k127_341392_4 485913.Krac_4939 1.542e-85 291.0 COG2120@1|root,COG2120@2|Bacteria,2G9IP@200795|Chloroflexi 200795|Chloroflexi S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L YYD3_k127_341392_5 1121904.ARBP01000006_gene3740 2.589e-38 149.0 COG0457@1|root,COG0457@2|Bacteria,4PBAK@976|Bacteroidetes,47VJ2@768503|Cytophagia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - YYD3_k127_341392_0 313606.M23134_00483 4.463e-198 627.0 COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes,47MZ0@768503|Cytophagia 976|Bacteroidetes E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC YYD3_k127_341392_2 1379698.RBG1_1C00001G1676 4.389e-137 442.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,2NPBE@2323|unclassified Bacteria 2|Bacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR YYD3_k127_341392_8 1382358.JHVN01000009_gene3314 9.916e-07 59.0 COG5513@1|root,COG5513@2|Bacteria,1V52X@1239|Firmicutes,4HEMU@91061|Bacilli,21VWB@150247|Anoxybacillus 91061|Bacilli S Domain of unknown function (DUF4163) - - - - - - - - - - - - Cu_amine_oxidN1,DUF3298,DUF4163 YYD3_k127_3427658_16 314232.SKA53_13876 1.76e-21 96.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,2P8MP@245186|Loktanella 28211|Alphaproteobacteria S Tetratricopeptide repeat MA20_42300 - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 YYD3_k127_3427658_13 1519464.HY22_03435 4.516e-33 146.0 COG2372@1|root,COG2372@2|Bacteria,1FE0C@1090|Chlorobi 1090|Chlorobi S Bacterial Ig-like domain - - - - - - - - - - - - Big_5 YYD3_k127_3427658_17 1123033.ARNF01000067_gene611 2.674e-17 89.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,3NKBN@468|Moraxellaceae 1236|Gammaproteobacteria M Belongs to the ompA family pal GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032153,GO:0044425,GO:0044462,GO:0044464,GO:0051301,GO:0071944,GO:0098552 - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA YYD3_k127_3427658_4 1379698.RBG1_1C00001G0882 9.128e-84 287.0 COG0395@1|root,COG0395@2|Bacteria,2NPFW@2323|unclassified Bacteria 2|Bacteria U binding-protein-dependent transport systems inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 YYD3_k127_3427658_5 1379698.RBG1_1C00001G0883 1.772e-82 283.0 COG1175@1|root,COG1175@2|Bacteria,2NPDA@2323|unclassified Bacteria 2|Bacteria G binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 YYD3_k127_3427658_2 1379698.RBG1_1C00001G0884 1.377e-95 327.0 COG2182@1|root,COG2182@2|Bacteria 2|Bacteria G maltose binding - - - ko:K02027,ko:K17329 ko02010,map02010 M00207,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.33 - - SBP_bac_1,SBP_bac_8 YYD3_k127_3427658_8 247490.KSU1_B0650 1.39e-60 218.0 28MEN@1|root,2ZASA@2|Bacteria,2IZ1H@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD3_k127_3427658_14 330214.NIDE2490 5.755e-32 132.0 29ZH8@1|root,30MGZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_3427658_9 247490.KSU1_B0648 4.354e-50 189.0 28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD3_k127_3427658_12 671143.DAMO_0351 1.446e-42 165.0 2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD3_k127_3427658_7 880073.Calab_1920 2.525e-63 227.0 COG1801@1|root,COG1801@2|Bacteria,2NPDU@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 YYD3_k127_3427658_3 1047013.AQSP01000052_gene2600 4.504e-87 297.0 COG4152@1|root,COG4152@2|Bacteria,2NQE2@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4162) natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 YYD3_k127_3427658_6 1047013.AQSP01000052_gene2599 2.33e-63 234.0 COG1668@1|root,COG1668@2|Bacteria,2NPCQ@2323|unclassified Bacteria 2|Bacteria CP ABC-2 family transporter protein natB - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 YYD3_k127_3427658_11 1229485.AMYV01000087_gene2831 5.052e-43 169.0 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,1RQBF@1236|Gammaproteobacteria,1J62W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S11 family pbpG GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 YYD3_k127_3427658_0 1379698.RBG1_1C00001G1165 5.095e-307 961.0 COG0495@1|root,COG0495@2|Bacteria,2NNQH@2323|unclassified Bacteria 2|Bacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iAF987.Gmet_2300 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 YYD3_k127_3427658_15 880073.Calab_3545 4.056e-27 122.0 COG0726@1|root,COG0726@2|Bacteria,2NPY1@2323|unclassified Bacteria 2|Bacteria G Polysaccharide deacetylase icaB - - - - - - - - - - - Glyco_transf_4,Polysacc_deac_1 YYD3_k127_3427658_1 1379698.RBG1_1C00001G1161 2.184e-123 412.0 COG0612@1|root,COG0612@2|Bacteria,2NNW3@2323|unclassified Bacteria 2|Bacteria S Belongs to the peptidase M16 family pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD3_k127_3427658_10 1379698.RBG1_1C00001G1160 2.515e-46 170.0 COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria 2|Bacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 YYD3_k127_3441533_0 644282.Deba_2080 2.318e-159 512.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family ugd - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N YYD3_k127_3441533_1 941449.dsx2_1185 3.719e-107 362.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WMGG@28221|Deltaproteobacteria,2MATU@213115|Desulfovibrionales 28221|Deltaproteobacteria H coenzyme F390 - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - - YYD3_k127_3441533_2 1123508.JH636443_gene4707 8.779e-84 292.0 COG0438@1|root,COG0438@2|Bacteria,2IZ69@203682|Planctomycetes 203682|Planctomycetes M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 YYD3_k127_3441533_3 1121439.dsat_1281 5.535e-58 215.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T55@68525|delta/epsilon subdivisions,2WPW2@28221|Deltaproteobacteria,2MG3X@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 YYD3_k127_3455343_1 1379698.RBG1_1C00001G1778 6.884e-100 330.0 COG1721@1|root,COG1721@2|Bacteria,2NNQI@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - - - - - - - - - - DUF58 YYD3_k127_3455343_0 1499967.BAYZ01000069_gene1846 5.686e-146 468.0 COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria 2|Bacteria S ATPase associated with various cellular moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 YYD3_k127_3455343_3 111105.HR09_04965 1.674e-07 62.0 COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,2FP8Y@200643|Bacteroidia,22XR6@171551|Porphyromonadaceae 976|Bacteroidetes O Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - YYD3_k127_3455343_2 348780.NP_4470A 7.037e-33 139.0 COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,23SVZ@183963|Halobacteria 183963|Halobacteria I Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids ubiA2 - 2.5.1.42 ko:K17105 ko00564,map00564 - R04520 RC01171 ko00000,ko00001,ko01000 - - - UbiA YYD3_k127_3455343_4 500635.MITSMUL_04365 0.0002242 50.0 COG4775@1|root,COG4775@2|Bacteria,1UMDS@1239|Firmicutes,4H27F@909932|Negativicutes 909932|Negativicutes M Outer membrane protein, OMP85 family yaeT - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD3_k127_3467157_2 309801.trd_A0778 3.331e-50 185.0 COG0439@1|root,COG0439@2|Bacteria,2G62X@200795|Chloroflexi,27YU8@189775|Thermomicrobia 189775|Thermomicrobia I acetyl-CoA carboxylase, biotin carboxylase - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 YYD3_k127_3467157_0 1379698.RBG1_1C00001G0988 9.42e-147 488.0 COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria 2|Bacteria C lyase activity - - 3.4.24.3 ko:K01387,ko:K03301 - - - - ko00000,ko01000,ko01002,ko02042 2.A.12 - - DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase YYD3_k127_3467157_4 1173023.KE650771_gene4830 0.000238 52.0 COG1413@1|root,COG1413@2|Bacteria,1G511@1117|Cyanobacteria,1JJSP@1189|Stigonemataceae 1117|Cyanobacteria C HEAT repeat - - - - - - - - - - - - HEAT_2,HEAT_PBS YYD3_k127_3467157_1 1379698.RBG1_1C00001G0990 5.227e-54 205.0 COG3359@1|root,COG3359@2|Bacteria,2NPCP@2323|unclassified Bacteria 2|Bacteria L RNase_H superfamily yprB - - ko:K07502 - - - - ko00000 - - - RNase_H_2 YYD3_k127_3467157_3 335541.Swol_1403 8.741e-12 69.0 COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,42KAI@68298|Syntrophomonadaceae 186801|Clostridia T HDOD domain - - - - - - - - - - - - HDOD,Response_reg YYD3_k127_3472677_1 1379698.RBG1_1C00001G1599 2.672e-213 668.0 COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria 2|Bacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0010467,GO:0016020,GO:0019538,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0034641,GO:0034645,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0090087,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 - ko:K02358,ko:K15771 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147 3.A.1.1.16,3.A.1.1.2 - iSB619.SA_RS02960 GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 YYD3_k127_3472677_6 28444.JODQ01000002_gene4223 4.418e-14 80.0 COG0457@1|root,COG0457@2|Bacteria,2H8D0@201174|Actinobacteria 201174|Actinobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - YYD3_k127_3472677_5 1379698.RBG1_1C00001G1130 3.923e-66 235.0 COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria 2|Bacteria G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895 NAD_kinase YYD3_k127_3472677_0 1379698.RBG1_1C00001G1879 1.329e-219 700.0 COG1154@1|root,COG1154@2|Bacteria,2NNNA@2323|unclassified Bacteria 2|Bacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C YYD3_k127_3472677_4 498761.HM1_0293 2.439e-81 280.0 COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia 186801|Clostridia H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt YYD3_k127_3472677_7 944481.JAFP01000001_gene1583 1.181e-09 61.0 COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2X2HT@28221|Deltaproteobacteria,2M7GT@213113|Desulfurellales 28221|Deltaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S YYD3_k127_3472677_3 1379698.RBG1_1C00001G1127 1.804e-102 347.0 COG1570@1|root,COG1570@2|Bacteria,2NNQT@2323|unclassified Bacteria 2|Bacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6,3.4.21.102 ko:K03601,ko:K03797 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko01002,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 YYD3_k127_3472677_2 1379698.RBG1_1C00001G1025 3.444e-171 552.0 COG0322@1|root,COG0322@2|Bacteria,2NNQ4@2323|unclassified Bacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N YYD3_k127_3478925_4 880073.Calab_2467 1.22e-12 69.0 COG1721@1|root,COG1721@2|Bacteria,2NNQI@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - - - - - - - - - - DUF58 YYD3_k127_3478925_3 880073.Calab_2468 1.74e-30 132.0 COG0760@1|root,COG0760@2|Bacteria,2NRND@2323|unclassified Bacteria 2|Bacteria O Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N,SurA_N_3 YYD3_k127_3478925_2 1379698.RBG1_1C00001G1776 6.333e-39 158.0 COG3088@1|root,COG3088@2|Bacteria,2NS4V@2323|unclassified Bacteria 2|Bacteria O subunit of a heme lyase ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564 - ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018 - - R05712 RC00176 ko00000,ko02000 9.B.14.1 - - CcmH YYD3_k127_3478925_0 1379698.RBG1_1C00001G1775 1.887e-109 364.0 COG2304@1|root,COG2304@2|Bacteria,2NNYH@2323|unclassified Bacteria 2|Bacteria NU von Willebrand factor (vWF) type A domain batA - - ko:K07114,ko:K12511 - - - - ko00000,ko02000,ko02044 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA YYD3_k127_3478925_1 880073.Calab_2475 1.546e-40 157.0 COG2304@1|root,COG2304@2|Bacteria,2NP2F@2323|unclassified Bacteria 2|Bacteria S von Willebrand factor (vWF) type A domain batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 YYD3_k127_3493878_19 768706.Desor_3321 5.229e-10 69.0 COG2227@1|root,COG2227@2|Bacteria,1UJIQ@1239|Firmicutes,25F3P@186801|Clostridia,2631M@186807|Peptococcaceae 186801|Clostridia H Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_25 YYD3_k127_3493878_8 1379698.RBG1_1C00001G1046 8.904e-72 254.0 COG1940@1|root,COG1940@2|Bacteria,2NPRP@2323|unclassified Bacteria 2|Bacteria GK ROK family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK YYD3_k127_3493878_20 306263.Cla_0288 8.774e-06 49.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2YMPZ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S hmm pf04305 - - - - - - - - - - - - DUF455 YYD3_k127_3493878_4 696281.Desru_0552 7.836e-114 379.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,260DD@186807|Peptococcaceae 186801|Clostridia EK PFAM Aminotransferase class I and II - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 YYD3_k127_3493878_15 985665.HPL003_24500 2.436e-50 189.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,4HBH4@91061|Bacilli,26QWK@186822|Paenibacillaceae 91061|Bacilli E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase YYD3_k127_3493878_3 330214.NIDE2040 2.517e-134 444.0 COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae 40117|Nitrospirae EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind YYD3_k127_3493878_7 321332.CYB_2417 9.638e-75 255.0 COG0512@1|root,COG0512@2|Bacteria,1G0QK@1117|Cyanobacteria,1GZ8F@1129|Synechococcus 1117|Cyanobacteria EH Anthranilate synthase trpG - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase YYD3_k127_3493878_5 644966.Tmar_1454 3.417e-96 327.0 COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,3WCZN@538999|Clostridiales incertae sedis 186801|Clostridia E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 YYD3_k127_3493878_11 351160.RCIX86 6.58e-62 229.0 COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota,2NAK2@224756|Methanomicrobia 224756|Methanomicrobia G MFS/sugar transport protein - - - - - - - - - - - - MFS_1 YYD3_k127_3493878_10 1449126.JQKL01000014_gene2975 5.911e-64 228.0 COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia,268Z9@186813|unclassified Clostridiales 186801|Clostridia E Indole-3-glycerol phosphate synthase trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS YYD3_k127_3493878_16 1182590.BN5_02125 4.978e-40 156.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1YD0W@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI YYD3_k127_3493878_0 1382303.JPOM01000001_gene1992 8.907e-171 544.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,2KFB5@204458|Caulobacterales 204458|Caulobacterales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP YYD3_k127_3493878_12 477974.Daud_1185 8.317e-58 211.0 COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,261Y5@186807|Peptococcaceae 186801|Clostridia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA YYD3_k127_3493878_1 1511.CLOST_1149 6.895e-154 506.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,25QY6@186804|Peptostreptococcaceae 186801|Clostridia J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d YYD3_k127_3493878_2 1382359.JIAL01000001_gene383 6.969e-140 451.0 COG2876@1|root,COG2876@2|Bacteria,3Y32G@57723|Acidobacteria,2JIXH@204432|Acidobacteriia 204432|Acidobacteriia E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 YYD3_k127_3493878_6 180332.JTGN01000007_gene3507 9.032e-96 329.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase YYD3_k127_3493878_17 444158.MmarC6_1719 1.757e-35 146.0 COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,23QN8@183939|Methanococci 183939|Methanococci E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0003674,GO:0003824,GO:0004764,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0055114,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N YYD3_k127_3493878_18 436114.SYO3AOP1_0528 6.793e-26 114.0 COG0703@1|root,COG0703@2|Bacteria,2G46N@200783|Aquificae 200783|Aquificae F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI YYD3_k127_3493878_9 1502770.JQMG01000001_gene601 1.064e-69 250.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,2KMCZ@206350|Nitrosomonadales 206350|Nitrosomonadales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase YYD3_k127_3493878_14 279010.BL01544 2.796e-51 185.0 COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,4HJ2V@91061|Bacilli,1ZG8H@1386|Bacillus 91061|Bacilli E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II YYD3_k127_3493878_13 880073.Calab_0837 1.202e-51 196.0 COG0534@1|root,COG0534@2|Bacteria,2NPBA@2323|unclassified Bacteria 2|Bacteria V MATE efflux family protein mepA_10 - - - - - - - - - - - MatE YYD3_k127_3494544_0 935836.JAEL01000006_gene2784 3.81e-30 135.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4HA13@91061|Bacilli,1ZCMB@1386|Bacillus 91061|Bacilli E Aminotransferase aspB GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 ko:K00812,ko:K22457 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052 RC00006,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_3508417_1 1379698.RBG1_1C00001G1403 3.207e-137 445.0 COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria 2|Bacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_2,GSDH YYD3_k127_3508417_3 1122925.KB895377_gene1481 5.878e-31 134.0 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,4H9RF@91061|Bacilli,26T0W@186822|Paenibacillaceae 91061|Bacilli L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon YYD3_k127_3508417_0 350688.Clos_1187 5.037e-151 492.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,36DCC@31979|Clostridiaceae 186801|Clostridia E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic YYD3_k127_3508417_2 1499967.BAYZ01000177_gene5744 1.679e-69 250.0 COG1368@1|root,COG1368@2|Bacteria,2NRZV@2323|unclassified Bacteria 2|Bacteria M Sulfatase - - - - - - - - - - - - Sulfatase YYD3_k127_3511472_1 998088.B565_2942 2.168e-66 235.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria,1Y3PQ@135624|Aeromonadales 135624|Aeromonadales E Belongs to the Orn Lys Arg decarboxylase class-II family - - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC YYD3_k127_3511472_0 643648.Slip_1551 2.182e-109 362.0 COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,42KBI@68298|Syntrophomonadaceae 186801|Clostridia H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth YYD3_k127_3511472_3 237368.SCABRO_01729 5.44e-41 161.0 COG0518@1|root,COG0518@2|Bacteria,2J0QU@203682|Planctomycetes 203682|Planctomycetes F Glutamine amidotransferase class-I - - - - - - - - - - - - GATase YYD3_k127_3511472_4 533247.CRD_01203 1.007e-26 112.0 COG0724@1|root,COG0724@2|Bacteria,1G7Q7@1117|Cyanobacteria,1HP3U@1161|Nostocales 1117|Cyanobacteria S RNA recognition motif - - - - - - - - - - - - RRM_1 YYD3_k127_3511472_2 269799.Gmet_0342 2.292e-60 215.0 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1R4WG@1224|Proteobacteria,43AIM@68525|delta/epsilon subdivisions,2X5YU@28221|Deltaproteobacteria,43SWZ@69541|Desulfuromonadales 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 YYD3_k127_3514048_2 1379698.RBG1_1C00001G0978 8.288e-68 243.0 COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents permease component - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE YYD3_k127_3514048_1 1379698.RBG1_1C00001G0979 1.814e-79 273.0 COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran YYD3_k127_3514048_0 796606.BMMGA3_00555 1.764e-134 443.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,1ZB8H@1386|Bacillus 91061|Bacilli O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI YYD3_k127_3521766_16 179408.Osc7112_1799 2.782e-13 72.0 COG1308@1|root,COG1308@2|Bacteria,1G83N@1117|Cyanobacteria,1HC9J@1150|Oscillatoriales 1117|Cyanobacteria K Domain of unknown function (DUF4342) - - - - - - - - - - - - DUF4342 YYD3_k127_3521766_13 1120968.AUBX01000009_gene84 2.449e-32 132.0 COG0454@1|root,COG0456@2|Bacteria,4NHRI@976|Bacteroidetes,47RPY@768503|Cytophagia 976|Bacteroidetes K PFAM Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 YYD3_k127_3521766_2 246194.CHY_1350 4.572e-124 408.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales 186801|Clostridia C PFAM Acyl-CoA dehydrogenase bcd2 - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin YYD3_k127_3521766_9 1379698.RBG1_1C00001G1006 1.322e-56 207.0 COG0682@1|root,COG0682@2|Bacteria,2NPK2@2323|unclassified Bacteria 2|Bacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT YYD3_k127_3521766_12 1379698.RBG1_1C00001G0055 3.481e-43 170.0 COG0671@1|root,COG0671@2|Bacteria,2NRVZ@2323|unclassified Bacteria 2|Bacteria I PAP2 superfamily - - - - - - - - - - - - PAP2_3 YYD3_k127_3521766_7 543734.LCABL_24370 8.131e-70 245.0 COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,4HAH8@91061|Bacilli,3F4AI@33958|Lactobacillaceae 91061|Bacilli H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase YYD3_k127_3521766_8 648996.Theam_0757 1.123e-69 245.0 COG0171@1|root,COG0171@2|Bacteria,2G425@200783|Aquificae 200783|Aquificae H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase YYD3_k127_3521766_11 1379698.RBG1_1C00001G0504 5.465e-46 172.0 COG0629@1|root,COG0629@2|Bacteria,2NPP5@2323|unclassified Bacteria 2|Bacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB YYD3_k127_3521766_5 105559.Nwat_2888 1.466e-83 289.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales 135613|Chromatiales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD YYD3_k127_3521766_15 1379698.RBG1_1C00001G1847 1.332e-20 98.0 COG2825@1|root,COG2825@2|Bacteria,2NQ6C@2323|unclassified Bacteria 2|Bacteria M Outer membrane protein (OmpH-like) ompH - - ko:K06142 - - - - ko00000 - - - OmpH YYD3_k127_3521766_1 1379698.RBG1_1C00001G1846 1.834e-189 621.0 COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria 2|Bacteria M Surface antigen bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD3_k127_3521766_14 641491.DND132_1464 8.817e-22 98.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,42SGM@68525|delta/epsilon subdivisions,2WQ3I@28221|Deltaproteobacteria,2MCRH@213115|Desulfovibrionales 28221|Deltaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p YYD3_k127_3521766_0 1379698.RBG1_1C00001G1551 3.077e-289 902.0 COG0556@1|root,COG0556@2|Bacteria,2NNPM@2323|unclassified Bacteria 2|Bacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006950,GO:0008150,GO:0009314,GO:0009380,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0032991,GO:0035821,GO:0042802,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB YYD3_k127_3521766_17 279714.FuraDRAFT_1567 0.000579 49.0 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2VUM6@28216|Betaproteobacteria,2KRAB@206351|Neisseriales 206351|Neisseriales S Psort location CytoplasmicMembrane, score cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V YYD3_k127_3521766_6 1379698.RBG1_1C00001G1834 2.334e-71 249.0 COG1028@1|root,COG1028@2|Bacteria,2NQVI@2323|unclassified Bacteria 2|Bacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.3.1.104 ko:K10780 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 YYD3_k127_3521766_10 555079.Toce_0610 5.625e-50 186.0 COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia,42FUN@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB YYD3_k127_3521766_4 1379698.RBG1_1C00001G0523 7.364e-101 344.0 COG0508@1|root,COG0508@2|Bacteria,2NNZ8@2323|unclassified Bacteria 2|Bacteria C e3 binding domain sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.168,2.3.1.61 ko:K00658,ko:K09699 ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00036 R02570,R02571,R02662,R03174,R04097,R08549,R10998 RC00004,RC02727,RC02833,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2766,iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding YYD3_k127_3521766_3 1379698.RBG1_1C00001G1873 4.378e-122 398.0 COG0379@1|root,COG0379@2|Bacteria,2NP47@2323|unclassified Bacteria 2|Bacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA YYD3_k127_3523285_5 671143.DAMO_2710 3.609e-46 169.0 COG0649@1|root,COG0649@2|Bacteria,2NNXB@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa YYD3_k127_3523285_4 880072.Desac_1204 2.334e-100 340.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MQ5S@213462|Syntrophobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh YYD3_k127_3523285_10 1121403.AUCV01000012_gene4037 2e-25 113.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42SZV@68525|delta/epsilon subdivisions,2WP8T@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338,ko:K05580 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_4,Fer4_7 YYD3_k127_3523285_9 867845.KI911784_gene1875 1.953e-25 112.0 COG0839@1|root,COG0839@2|Bacteria,2G777@200795|Chloroflexi,375K1@32061|Chloroflexia 32061|Chloroflexia C Belongs to the complex I subunit 6 family - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 YYD3_k127_3523285_8 671143.DAMO_2707 7.774e-30 123.0 COG0713@1|root,COG0713@2|Bacteria,2NQ6R@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 YYD3_k127_3523285_0 246194.CHY_1417 3.378e-167 548.0 COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia,42FX8@68295|Thermoanaerobacterales 186801|Clostridia C NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus ndhF - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N YYD3_k127_3523285_1 880073.Calab_2684 1.005e-161 523.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM2 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M YYD3_k127_3523285_3 1121468.AUBR01000050_gene2028 1.343e-102 351.0 COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia,42FCA@68295|Thermoanaerobacterales 186801|Clostridia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M YYD3_k127_3523285_6 1379698.RBG1_1C00001G0360 2.158e-44 169.0 COG2928@1|root,COG2928@2|Bacteria,2NR55@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 YYD3_k127_3523285_7 665571.STHERM_c07970 2.789e-40 161.0 COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system ptsN_1 - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - CBS,HTH_17,PTS_EIIA_2 YYD3_k127_3523285_2 479434.Sthe_2452 7.554e-104 351.0 COG0530@1|root,COG0530@2|Bacteria 2|Bacteria P calcium, potassium:sodium antiporter activity - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex YYD3_k127_3523285_11 247490.KSU1_C0659 8.597e-19 95.0 COG0612@1|root,COG0612@2|Bacteria,2IWSI@203682|Planctomycetes 203682|Planctomycetes S Belongs to the peptidase M16 family - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD3_k127_3532420_0 1379698.RBG1_1C00001G0186 3.016e-161 518.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N YYD3_k127_3532420_12 237368.SCABRO_03012 1.026e-47 181.0 2ANS9@1|root,31DS7@2|Bacteria,2IZX5@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD3_k127_3532420_10 247490.KSU1_B0648 7.72e-58 211.0 28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD3_k127_3532420_13 330214.NIDE2490 2.86e-44 169.0 29ZH8@1|root,30MGZ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_3532420_4 1379698.RBG1_1C00001G0119 6.868e-91 314.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD3_k127_3532420_9 756272.Plabr_3384 6.58e-61 220.0 2ANS9@1|root,31DS7@2|Bacteria,2IZX5@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD3_k127_3532420_8 756272.Plabr_3383 3.073e-61 224.0 28MYQ@1|root,2ZB5K@2|Bacteria,2IZUC@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD3_k127_3532420_11 1379698.RBG1_1C00001G0118 2.117e-53 196.0 29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_3532420_3 344747.PM8797T_23691 5.77e-110 369.0 28MEN@1|root,2ZASA@2|Bacteria,2IZ1H@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - YYD3_k127_3532420_7 1379698.RBG1_1C00001G0116 2.792e-74 256.0 2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD3_k127_3532420_5 1379698.RBG1_1C00001G0117 8.054e-90 306.0 28MYQ@1|root,2ZB5K@2|Bacteria,2NPC8@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD3_k127_3532420_6 1379698.RBG1_1C00001G0118 4.252e-76 260.0 29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_3532420_1 1379698.RBG1_1C00001G0119 2.771e-114 382.0 28MEN@1|root,2ZASA@2|Bacteria,2NQD3@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD3_k127_3532420_2 1379698.RBG1_1C00001G0122 2.927e-114 371.0 COG1070@1|root,COG1070@2|Bacteria,2NP2A@2323|unclassified Bacteria 2|Bacteria G MutL protein - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N,MutL YYD3_k127_3540105_2 1242864.D187_001647 2.512e-91 305.0 COG2124@1|root,COG2124@2|Bacteria 2|Bacteria Q cytochrome p450 - - - - - - - - - - - - p450 YYD3_k127_3540105_1 1191523.MROS_1186 2.267e-122 409.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT,Cytochrom_c3_2 YYD3_k127_3540105_13 518766.Rmar_0609 6.104e-12 74.0 2FFT5@1|root,347QA@2|Bacteria,4P5W2@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - DUF4398 YYD3_k127_3540105_9 518766.Rmar_0610 1.728e-43 173.0 COG3034@1|root,COG3034@2|Bacteria,4NU5W@976|Bacteroidetes 976|Bacteroidetes M L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD YYD3_k127_3540105_10 927658.AJUM01000034_gene466 5.845e-40 156.0 COG1376@1|root,COG1376@2|Bacteria,4P35B@976|Bacteroidetes 976|Bacteroidetes S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD YYD3_k127_3540105_12 1210884.HG799465_gene11731 3.408e-14 76.0 COG1393@1|root,COG1393@2|Bacteria,2J19I@203682|Planctomycetes 203682|Planctomycetes P Belongs to the ArsC family - - - - - - - - - - - - - YYD3_k127_3540105_11 243274.THEMA_00010 2.174e-26 116.0 COG0220@1|root,COG0220@2|Bacteria,2GCR3@200918|Thermotogae 200918|Thermotogae J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 YYD3_k127_3540105_4 1125863.JAFN01000001_gene1695 1.979e-80 287.0 COG3005@1|root,COG3005@2|Bacteria,1RJ3G@1224|Proteobacteria,42ST3@68525|delta/epsilon subdivisions 1224|Proteobacteria C NapC/NirT cytochrome c family, N-terminal region - - - - - - - - - - - - Cytochrom_CIII,Cytochrom_NNT,Cytochrome_C7 YYD3_k127_3540105_8 880072.Desac_0068 2.422e-52 196.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WR70@28221|Deltaproteobacteria 28221|Deltaproteobacteria C formate dehydrogenase - - - - - - - - - - - - - YYD3_k127_3540105_7 204669.Acid345_2713 4.269e-62 226.0 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria 57723|Acidobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB YYD3_k127_3540105_5 671143.DAMO_0825 1.043e-79 280.0 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria 2|Bacteria C Cytochrome b subunit of formate dehydrogenase-like protein mccA GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016002,GO:0016043,GO:0016491,GO:0016667,GO:0017144,GO:0019748,GO:0020037,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044272,GO:0044550,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051259,GO:0051260,GO:0055114,GO:0065003,GO:0070206,GO:0070207,GO:0070813,GO:0070814,GO:0071840,GO:0097159,GO:1901363,GO:1903136 - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1 YYD3_k127_3540105_0 247490.KSU1_C0602 3.03e-140 456.0 COG2133@1|root,COG2133@2|Bacteria,2IXAF@203682|Planctomycetes 203682|Planctomycetes G glucose sorbosone - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - DUF1080,GSDH,SGL YYD3_k127_3540105_6 55601.VANGNB10_cII0274c 9.69e-77 263.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XSYR@135623|Vibrionales 135623|Vibrionales V Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD3_k127_3540105_3 518766.Rmar_1442 5.891e-82 283.0 COG0577@1|root,COG0577@2|Bacteria,4NECN@976|Bacteroidetes,1FIY8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD3_k127_3552550_2 1519464.HY22_12570 3.715e-27 127.0 COG4288@1|root,COG4288@2|Bacteria,1FE3D@1090|Chlorobi 1090|Chlorobi S Lamin Tail Domain - - - - - - - - - - - - CHU_C,FlgD_ig,LTD YYD3_k127_3552550_1 1379698.RBG1_1C00001G1866 9.508e-101 345.0 COG2204@1|root,COG2204@2|Bacteria,2NQDH@2323|unclassified Bacteria 2|Bacteria T Sigma-54 interaction domain fhlA - - ko:K03413,ko:K13589 ko02020,ko02030,ko04112,map02020,map02030,map04112 M00506,M00512 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_3552550_0 555079.Toce_1819 2.396e-156 513.0 COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,42FKG@68295|Thermoanaerobacterales 186801|Clostridia J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 YYD3_k127_3599440_2 313606.M23134_02886 1.238e-06 59.0 COG1452@1|root,COG1452@2|Bacteria,4NFWD@976|Bacteroidetes,47JIS@768503|Cytophagia 976|Bacteroidetes M Organic solvent tolerance protein OstA - - - - - - - - - - - - - YYD3_k127_3599440_1 330214.NIDE0404 1.002e-25 108.0 COG0776@1|root,COG0776@2|Bacteria,3J0V6@40117|Nitrospirae 40117|Nitrospirae L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions - - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding YYD3_k127_3599440_0 1379698.RBG1_1C00001G0866 1.16e-203 658.0 COG1674@1|root,COG1674@2|Bacteria,2NNVB@2323|unclassified Bacteria 2|Bacteria D Ftsk_gamma ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma YYD3_k127_362418_3 247634.GPB2148_313 2.624e-06 58.0 COG1520@1|root,COG4249@1|root,COG1520@2|Bacteria,COG4249@2|Bacteria,1QSQ3@1224|Proteobacteria,1RW8C@1236|Gammaproteobacteria,1JAW1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Caspase domain - - - - - - - - - - - - Peptidase_C14 YYD3_k127_362418_1 1121472.AQWN01000001_gene239 2.661e-46 175.0 COG2859@1|root,COG2859@2|Bacteria,1V1Q4@1239|Firmicutes,24GEE@186801|Clostridia,264GJ@186807|Peptococcaceae 186801|Clostridia S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL YYD3_k127_362418_0 1484479.DI14_04970 2.604e-184 585.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,3WDYC@539002|Bacillales incertae sedis 91061|Bacilli G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N YYD3_k127_362418_2 498848.TaqDRAFT_4490 2.334e-29 124.0 COG0641@1|root,COG0641@2|Bacteria,1WJKB@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C 4Fe-4S single cluster domain - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM YYD3_k127_3634839_0 1379698.RBG1_1C00001G0322 1.702e-70 250.0 COG2385@1|root,COG2385@2|Bacteria,2NPRR@2323|unclassified Bacteria 2|Bacteria D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID YYD3_k127_3634839_1 1123256.KB907928_gene2150 9.481e-42 171.0 COG2885@1|root,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,1RP3K@1236|Gammaproteobacteria,1X9H3@135614|Xanthomonadales 135614|Xanthomonadales M OmpA family - - - - - - - - - - - - OmpA,TSP_3 YYD3_k127_3634839_2 1211814.CAPG01000010_gene342 2.417e-10 68.0 COG1514@1|root,COG1514@2|Bacteria,1V2F3@1239|Firmicutes,4HG6P@91061|Bacilli,1ZG9R@1386|Bacillus 91061|Bacilli J Belongs to the 2H phosphoesterase superfamily. YjcG family yjcG - - - - - - - - - - - 2_5_RNA_ligase2 YYD3_k127_3634839_3 880073.Calab_2066 7.494e-05 46.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family ebh - - - - - - - - - - - DUF1611,Inhibitor_I9,Peptidase_S8,SLH YYD3_k127_3644424_2 321327.CYA_1206 8.524e-14 84.0 COG0031@1|root,COG0031@2|Bacteria,1GBK3@1117|Cyanobacteria,1H00H@1129|Synechococcus 1117|Cyanobacteria E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP YYD3_k127_3644424_1 1379698.RBG1_1C00001G0290 6.125e-54 209.0 COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 YYD3_k127_3644424_0 945713.IALB_2739 2.788e-94 312.0 COG0114@1|root,COG0114@2|Bacteria 2|Bacteria C fumarate hydratase activity fumC GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 YYD3_k127_3654031_1 562970.Btus_2421 2.961e-68 237.0 COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,4HE3C@91061|Bacilli,278AS@186823|Alicyclobacillaceae 91061|Bacilli H Belongs to the UbiD family - - - - - - - - - - - - UbiD YYD3_k127_3654031_3 1232410.KI421426_gene1437 5.814e-50 185.0 arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,43UQJ@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_3654031_4 683837.lse_2655 3.239e-16 83.0 2E5AU@1|root,3302Y@2|Bacteria,1VB5Y@1239|Firmicutes,4HPUD@91061|Bacilli,26KPZ@186820|Listeriaceae 91061|Bacilli S Src homology 3 domains - - - - - - - - - - - - SH3_1,SH3_2 YYD3_k127_3654031_0 635013.TherJR_2454 9.848e-77 271.0 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,260TE@186807|Peptococcaceae 186801|Clostridia H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM YYD3_k127_3654031_2 1379698.RBG1_1C00001G0429 1.417e-57 205.0 COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria 2|Bacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 YYD3_k127_3692130_2 518766.Rmar_0418 5.01e-92 315.0 COG1132@1|root,COG1132@2|Bacteria,4NEAG@976|Bacteroidetes,1FIQC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes V ABC transporter transmembrane region - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran YYD3_k127_3692130_1 485918.Cpin_5496 7.935e-99 344.0 COG1132@1|root,COG1132@2|Bacteria,4NDY6@976|Bacteroidetes,1IPDM@117747|Sphingobacteriia 976|Bacteroidetes V ABC transporter mdlA - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran YYD3_k127_3692130_0 243231.GSU2357 5.145e-99 336.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel YYD3_k127_3692130_3 1047013.AQSP01000110_gene67 3.099e-58 209.0 COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria 2|Bacteria P CorA-like Mg2+ transporter protein corA GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA YYD3_k127_3692938_1 518766.Rmar_2487 2.85e-47 177.0 COG0101@1|root,COG0101@2|Bacteria,4NFDC@976|Bacteroidetes,1FJ65@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 YYD3_k127_3692938_2 1246484.D479_09110 1.358e-46 177.0 COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,4H9VT@91061|Bacilli,3NDE6@45667|Halobacillus 91061|Bacilli U Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfT - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ YYD3_k127_3692938_0 518766.Rmar_2567 6.844e-87 304.0 COG0370@1|root,COG0370@2|Bacteria,4NEII@976|Bacteroidetes 976|Bacteroidetes P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate YYD3_k127_3701285_4 1333856.L686_10185 2.051e-13 83.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1Z2CJ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria D Chain length determinant protein - - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - AAA_31,CBP_BcsQ,CbiA,GNVR,Wzz YYD3_k127_3701285_3 338963.Pcar_2867 1.181e-51 187.0 COG3005@1|root,COG3005@2|Bacteria,1N0I4@1224|Proteobacteria,42R1B@68525|delta/epsilon subdivisions,2WQMW@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NapC/NirT cytochrome c family, N-terminal region nrfH - - ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_NNT YYD3_k127_3701285_0 247490.KSU1_B0055 8.523e-198 627.0 COG3303@1|root,COG3303@2|Bacteria,2IYGG@203682|Planctomycetes 203682|Planctomycetes C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_C552 YYD3_k127_3701285_6 1148.1653840 8.255e-05 53.0 COG0288@1|root,COG0288@2|Bacteria,1G76H@1117|Cyanobacteria,1H6KK@1142|Synechocystis 1117|Cyanobacteria P reversible hydration of carbon dioxide - - - - - - - - - - - - - YYD3_k127_3701285_1 673860.AciM339_1072 2.409e-117 391.0 COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota,3F2Z7@33867|unclassified Euryarchaeota 28890|Euryarchaeota K PFAM Aminotransferase class I and II - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 YYD3_k127_3701285_2 1380394.JADL01000004_gene6049 2.067e-103 352.0 COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,2TQZZ@28211|Alphaproteobacteria,2JPG0@204441|Rhodospirillales 204441|Rhodospirillales K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - - - - - - - - - - Aminotran_1_2,GntR YYD3_k127_3701285_5 439235.Dalk_4320 4.355e-10 70.0 2DS9E@1|root,32VU1@2|Bacteria,1P3D6@1224|Proteobacteria,431R2@68525|delta/epsilon subdivisions,2WW7F@28221|Deltaproteobacteria,2MNTP@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_3713029_5 1449126.JQKL01000005_gene874 3.901e-25 107.0 COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,268Q6@186813|unclassified Clostridiales 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt YYD3_k127_3713029_0 1379698.RBG1_1C00001G0153 2.601e-239 745.0 COG0055@1|root,COG0055@2|Bacteria,2NNRB@2323|unclassified Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N YYD3_k127_3713029_3 1379698.RBG1_1C00001G0155 5.818e-32 129.0 COG0355@1|root,COG0355@2|Bacteria,2NPSQ@2323|unclassified Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01195,iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190 ATP-synt_DE,ATP-synt_DE_N YYD3_k127_3713029_6 1379698.RBG1_1C00001G1830 2.873e-24 109.0 COG1399@1|root,COG1399@2|Bacteria,2NPVD@2323|unclassified Bacteria 2|Bacteria S Uncharacterized ACR, COG1399 yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K07040 - - - - ko00000 - - - DUF177 YYD3_k127_3713029_7 1379698.RBG1_1C00001G1829 1.742e-23 100.0 COG0333@1|root,COG0333@2|Bacteria,2NQ1M@2323|unclassified Bacteria 2|Bacteria J Ribosomal L32p protein family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p YYD3_k127_3713029_2 1379698.RBG1_1C00001G1828 6.602e-83 288.0 COG0416@1|root,COG0416@2|Bacteria,2NP1H@2323|unclassified Bacteria 2|Bacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis YYD3_k127_3713029_1 697303.Thewi_1430 7.531e-110 364.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42ER1@68295|Thermoanaerobacterales 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C YYD3_k127_3713029_4 1379698.RBG1_1C00001G1827 5.109e-28 117.0 COG0331@1|root,COG0331@2|Bacteria,2NP3V@2323|unclassified Bacteria 2|Bacteria I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645,ko:K15327,ko:K15329,ko:K15355,ko:K15469 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - Acyl_transf_1 YYD3_k127_3713029_8 926566.Terro_1965 6.492e-07 53.0 COG0624@1|root,COG0624@2|Bacteria,3Y2K0@57723|Acidobacteria,2JIEY@204432|Acidobacteriia 204432|Acidobacteriia E PFAM peptidase - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 YYD3_k127_3761463_1 498761.HM1_1843 2.371e-48 182.0 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia 186801|Clostridia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS16615 ACT_4,HD_4,RelA_SpoT,TGS YYD3_k127_3761463_0 521674.Plim_1325 8.56e-211 676.0 COG0587@1|root,COG0587@2|Bacteria,2IWSE@203682|Planctomycetes 203682|Planctomycetes L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP YYD3_k127_3768428_6 1379698.RBG1_1C00001G0231 1.048e-27 124.0 COG1413@1|root,COG1413@2|Bacteria,2NRMK@2323|unclassified Bacteria 2|Bacteria C HEAT repeats CP_0755 - - - - - - - - - - - HEAT_2,HEAT_PBS,Response_reg YYD3_k127_3768428_1 1379698.RBG1_1C00001G0230 2.14e-99 343.0 COG2206@1|root,COG2206@2|Bacteria,2NPP4@2323|unclassified Bacteria 2|Bacteria T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD YYD3_k127_3768428_9 518766.Rmar_0450 2.008e-06 57.0 28PR3@1|root,30SU9@2|Bacteria,4P9QM@976|Bacteroidetes,1FJHG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_3768428_8 1220582.RRU01S_26_01200 1.295e-14 85.0 COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2TT5I@28211|Alphaproteobacteria,4BCWB@82115|Rhizobiaceae 28211|Alphaproteobacteria I Diacylglycerol kinase catalytic domain (presumed) - - - - - - - - - - - - DAGK_cat YYD3_k127_3768428_2 1379698.RBG1_1C00001G1327 4.127e-82 283.0 COG0382@1|root,COG0382@2|Bacteria,2NNVJ@2323|unclassified Bacteria 2|Bacteria H UbiA prenyltransferase family ubiA - - - - - - - - - - - UbiA YYD3_k127_3768428_3 1001585.MDS_1229 4.86e-68 243.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1YJRS@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P transporter MgtE mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N YYD3_k127_3768428_5 1379698.RBG1_1C00001G0536 2.262e-36 145.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA YYD3_k127_3768428_0 536227.CcarbDRAFT_4129 6.78e-129 422.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,36E5F@31979|Clostridiaceae 186801|Clostridia C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate icd - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh YYD3_k127_3768428_7 906968.Trebr_0917 8.766e-17 85.0 2EH48@1|root,33AW7@2|Bacteria,2J921@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - YYD3_k127_3768428_4 469381.Dpep_2027 3.115e-40 152.0 COG0156@1|root,COG0156@2|Bacteria,3TAG5@508458|Synergistetes 508458|Synergistetes H PFAM Aminotransferase class I and II - - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_3781942_3 387631.Asulf_00513 3.298e-36 143.0 COG0346@1|root,arCOG02706@2157|Archaea,2XY0R@28890|Euryarchaeota,2469B@183980|Archaeoglobi 183980|Archaeoglobi E Glyoxalase-like domain - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 YYD3_k127_3781942_5 697282.Mettu_3684 2.137e-28 118.0 2E3V1@1|root,32YSA@2|Bacteria,1N7HB@1224|Proteobacteria,1SF7K@1236|Gammaproteobacteria,1XGMP@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - YYD3_k127_3781942_6 1499968.TCA2_3865 7.195e-16 81.0 COG3682@1|root,COG3682@2|Bacteria,1VGZ0@1239|Firmicutes,4IRZT@91061|Bacilli,276ZA@186822|Paenibacillaceae 91061|Bacilli K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R YYD3_k127_3781942_0 1379698.RBG1_1C00001G1395 1.486e-141 460.0 28IS3@1|root,2Z8R9@2|Bacteria 2|Bacteria S Psort location Cytoplasmic, score - - - - - - - - - - - - Phage_capsid YYD3_k127_3785956_3 1379698.RBG1_1C00001G1261 5.31e-14 82.0 COG4966@1|root,COG4966@2|Bacteria 2|Bacteria NU pilus assembly protein PilW pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW YYD3_k127_3785956_1 1379270.AUXF01000004_gene3145 1.685e-41 172.0 COG4726@1|root,COG4726@2|Bacteria,1ZUS8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Pilus assembly protein PilX - - - - - - - - - - - - - YYD3_k127_3785956_0 1379698.RBG1_1C00001G0370 1.103e-121 421.0 COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria 2|Bacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 YYD3_k127_3785956_2 1177594.MIC448_2490003 1.808e-32 136.0 COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4FKF8@85023|Microbacteriaceae 201174|Actinobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family tsnR - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind YYD3_k127_3823185_1 1191523.MROS_1636 3.286e-23 106.0 COG1295@1|root,COG1295@2|Bacteria 2|Bacteria S lipopolysaccharide transmembrane transporter activity rbn - - ko:K03303,ko:K07058 - - - - ko00000,ko02000 2.A.14 - - Virul_fac_BrkB YYD3_k127_3823185_2 1168289.AJKI01000007_gene130 0.0006108 48.0 2DNS2@1|root,32YVY@2|Bacteria,4PHI7@976|Bacteroidetes,2G1E5@200643|Bacteroidia,3XKYI@558415|Marinilabiliaceae 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_3823185_0 378806.STAUR_7818 5.78e-200 637.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2YUAB@29|Myxococcales 28221|Deltaproteobacteria S ABC transporter yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn YYD3_k127_3824872_3 518766.Rmar_0586 1.665e-61 217.0 COG1575@1|root,COG1575@2|Bacteria,4NGCJ@976|Bacteroidetes,1FIUJ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Belongs to the MenA family. Type 1 subfamily menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA YYD3_k127_3824872_1 331678.Cphamn1_2077 3.374e-151 480.0 COG0447@1|root,COG0447@2|Bacteria,1FDH0@1090|Chlorobi 1090|Chlorobi H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 YYD3_k127_3824872_2 266117.Rxyl_2894 2.696e-67 237.0 COG2267@1|root,COG2267@2|Bacteria,2GYP0@201174|Actinobacteria,4CQF4@84995|Rubrobacteria 84995|Rubrobacteria I Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_6 YYD3_k127_3824872_0 266117.Rxyl_2896 7.36e-156 510.0 COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria,4CPYA@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N YYD3_k127_3824872_4 309807.SRU_1350 3.431e-07 52.0 COG1169@1|root,COG1169@2|Bacteria,4NF6U@976|Bacteroidetes,1FIXW@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes the conversion of chorismate to isochorismate entC - 5.4.4.2 ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind YYD3_k127_3829234_3 399795.CtesDRAFT_PD0947 2.648e-22 101.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VI60@28216|Betaproteobacteria,4A9Q2@80864|Comamonadaceae 28216|Betaproteobacteria M gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept YYD3_k127_3829234_0 1379698.RBG1_1C00001G0595 2.34e-141 475.0 COG1874@1|root,COG1874@2|Bacteria,2NRR5@2323|unclassified Bacteria 2|Bacteria G Glycosyl hydrolases family 35 - - 3.2.1.23 ko:K01190,ko:K12308 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Cellulase,Glyco_hydro_35,Glyco_hydro_42,Glyco_hydro_42M,Sulfotransfer_2 YYD3_k127_3829234_2 880073.Calab_0123 3.61e-28 126.0 COG2319@1|root,COG2319@2|Bacteria 2|Bacteria S anaphase-promoting complex binding - - - - - - - - - - - - Lectin_legB,NB-ARC,TIR_2,WD40 YYD3_k127_3829234_1 880073.Calab_1754 1.59e-79 294.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NQ6Y@2323|unclassified Bacteria 2|Bacteria M PKD domain - - 3.2.1.4,3.4.21.66 ko:K01179,ko:K08651 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko01002,ko03110 - GH5,GH9 - Autotransporter,PKD,Peptidase_S8,Peptidase_S8_N,fn3 YYD3_k127_3832930_1 215803.DB30_2152 2.55e-26 123.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RGQT@1224|Proteobacteria,42RK9@68525|delta/epsilon subdivisions,2WMYQ@28221|Deltaproteobacteria,2YYSP@29|Myxococcales 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - Response_reg YYD3_k127_3832930_3 1410670.JHXF01000012_gene2090 2.471e-14 77.0 COG0745@1|root,COG0745@2|Bacteria,1TPU2@1239|Firmicutes,24B71@186801|Clostridia,3WGHT@541000|Ruminococcaceae 186801|Clostridia T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C YYD3_k127_3832930_2 518766.Rmar_1797 3.54e-21 97.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1FJ5I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T Bacterial regulatory protein, Fis family ntrX - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_3832930_0 243231.GSU0599 2.103e-65 238.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42P9E@68525|delta/epsilon subdivisions,2WMH3@28221|Deltaproteobacteria,43SU5@69541|Desulfuromonadales 28221|Deltaproteobacteria T histidine kinase, HAMP - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 YYD3_k127_3908387_1 1444770.AF72_11465 4.945e-06 58.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1X527@135614|Xanthomonadales 135614|Xanthomonadales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD3_k127_3908387_0 1379698.RBG1_1C00001G1783 2.279e-52 213.0 COG5448@1|root,COG5448@2|Bacteria,2NPPC@2323|unclassified Bacteria 2|Bacteria S Glycoside hydrolase family 24 - - - - - - - - - - - - DUF2460 YYD3_k127_3908497_0 379066.GAU_2797 9.04e-46 175.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C YYD3_k127_3908497_1 195105.CN97_02185 4.412e-17 95.0 COG2244@1|root,COG2244@2|Bacteria,1N3BW@1224|Proteobacteria,2UE08@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Membrane protein involved in the export of O-antigen and teichoic - - - - - - - - - - - - Polysacc_synt_3 YYD3_k127_3913450_2 204669.Acid345_1334 3.762e-23 102.0 COG5295@1|root,COG5295@2|Bacteria,3Y72W@57723|Acidobacteria,2JM9T@204432|Acidobacteriia 2|Bacteria UW Hep Hag repeat protein yeeJ - - ko:K21449 - - - - ko00000,ko02000 1.B.40.2 - - DUF5122,Peptidase_S74,YadA_head,YadA_stalk YYD3_k127_3913450_0 215803.DB30_8826 1.338e-84 285.0 28H95@1|root,2Z7KY@2|Bacteria,1RA0C@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF4256) - - - - - - - - - - - - DUF4256 YYD3_k127_3913450_3 1379698.RBG1_1C00001G0282 2.195e-22 108.0 COG5276@1|root,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,LVIVD YYD3_k127_3913450_1 234267.Acid_7539 5.26e-25 108.0 COG0724@1|root,COG0724@2|Bacteria,3Y59V@57723|Acidobacteria 57723|Acidobacteria S RNA recognition motif - - - - - - - - - - - - RRM_1 YYD3_k127_3916641_1 1123261.AXDW01000005_gene2667 7.054e-62 219.0 COG1682@1|root,COG1682@2|Bacteria,1QXTH@1224|Proteobacteria,1SPS5@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM ABC-2 type transporter - - - - - - - - - - - - ABC2_membrane YYD3_k127_3916641_6 641491.DND132_0528 1.964e-18 98.0 COG2197@1|root,COG2203@1|root,COG2197@2|Bacteria,COG2203@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria 28221|Deltaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,PAS_4,PAS_9 YYD3_k127_3916641_7 1267211.KI669560_gene478 1.901e-15 89.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,4NFC3@976|Bacteroidetes,1IW1P@117747|Sphingobacteriia 976|Bacteroidetes T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg YYD3_k127_3916641_5 684949.ATTJ01000002_gene106 6.871e-21 98.0 2ECKJ@1|root,33KDJ@2|Bacteria,1WMG2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus - - - - - - - - - - - - - - DinB_2 YYD3_k127_3916641_0 1191523.MROS_0749 1.944e-164 526.0 COG0535@1|root,COG0535@2|Bacteria 2|Bacteria I radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM YYD3_k127_3916641_2 83219.PM02_10960 5.377e-57 224.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2TTUP@28211|Alphaproteobacteria,3ZVFM@60136|Sulfitobacter 28211|Alphaproteobacteria F Belongs to the 5'-nucleotidase family MA20_07595 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006213,GO:0006259,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007155,GO:0007159,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009164,GO:0009166,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019362,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0022610,GO:0031974,GO:0031981,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046135,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0072524,GO:0072527,GO:0072529,GO:0090304,GO:0098609,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5,3.6.1.45 ko:K01081,ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,LysM,Metallophos YYD3_k127_3916641_4 880073.Calab_0921 2.531e-23 117.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF4157,FctA,Peptidase_M43 YYD3_k127_3916641_8 1121926.AXWO01000015_gene4266 3.329e-05 51.0 COG3693@1|root,COG3693@2|Bacteria,2I8RT@201174|Actinobacteria 201174|Actinobacteria G hydrolase family 10 - - - - - - - - - - - - Glyco_hydro_10 YYD3_k127_3916641_3 485913.Krac_1233 1.589e-44 163.0 COG1028@1|root,COG1028@2|Bacteria,2G8SB@200795|Chloroflexi 200795|Chloroflexi IQ PFAM short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 YYD3_k127_3958377_2 468059.AUHA01000002_gene43 2.586e-102 343.0 COG3186@1|root,COG3186@2|Bacteria,4NEX5@976|Bacteroidetes,1IQDN@117747|Sphingobacteriia 976|Bacteroidetes E Biopterin-dependent aromatic amino acid hydroxylase phhA - 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 - R01795,R07211 RC00490 ko00000,ko00001,ko01000 - - - Biopterin_H YYD3_k127_3958377_8 867845.KI911784_gene3656 3.04e-49 184.0 COG4221@1|root,COG4221@2|Bacteria,2GBSD@200795|Chloroflexi,375PC@32061|Chloroflexia 32061|Chloroflexia S PFAM short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short YYD3_k127_3958377_7 1521187.JPIM01000030_gene1497 4.152e-56 211.0 COG0720@1|root,COG0720@2|Bacteria,2G992@200795|Chloroflexi,3753G@32061|Chloroflexia 32061|Chloroflexia H PFAM 6-pyruvoyl tetrahydropterin synthase and - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS YYD3_k127_3958377_9 880073.Calab_1147 1.05e-17 96.0 COG0720@1|root,COG0720@2|Bacteria,2NR5B@2323|unclassified Bacteria 2|Bacteria H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS YYD3_k127_3958377_4 1117647.M5M_01650 8.382e-80 272.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1J50N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0302 GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI YYD3_k127_3958377_6 1499967.BAYZ01000068_gene1924 6.071e-68 237.0 COG0704@1|root,COG0704@2|Bacteria,2NPWX@2323|unclassified Bacteria 2|Bacteria P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU YYD3_k127_3958377_1 335543.Sfum_2890 2.048e-110 363.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2MR99@213462|Syntrophobacterales 28221|Deltaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran YYD3_k127_3958377_0 404589.Anae109_0420 1.621e-111 368.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,2YVAR@29|Myxococcales 28221|Deltaproteobacteria P Phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 YYD3_k127_3958377_3 404589.Anae109_0419 3.46e-97 327.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2YV6J@29|Myxococcales 28221|Deltaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 YYD3_k127_3958377_5 1131812.JQMS01000001_gene1238 1.711e-77 266.0 COG0226@1|root,COG0226@2|Bacteria,4NJGR@976|Bacteroidetes,1I2BC@117743|Flavobacteriia,2NTPT@237|Flavobacterium 976|Bacteroidetes P PBP superfamily domain pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 YYD3_k127_397609_4 1089553.Tph_c18420 2.975e-05 49.0 COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,42FDP@68295|Thermoanaerobacterales 186801|Clostridia C Formate dehydrogenase alpha subunit fdhA - 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 YYD3_k127_397609_0 1379698.RBG1_1C00001G1057 9.267e-121 396.0 COG1005@1|root,COG1005@2|Bacteria,2NNTT@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh YYD3_k127_397609_1 1379698.RBG1_1C00001G1875 3.444e-68 235.0 COG1143@1|root,COG1143@2|Bacteria,2NPQR@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 ko:K00337,ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iNJ661.Rv3153 Fer4 YYD3_k127_397609_2 1379698.RBG1_1C00001G1058 3.088e-30 129.0 COG0839@1|root,COG0839@2|Bacteria,2NPUC@2323|unclassified Bacteria 2|Bacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 YYD3_k127_397609_3 408672.NBCG_01054 3.663e-12 67.0 COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4DRR0@85009|Propionibacteriales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 YYD3_k127_4028271_0 1379698.RBG1_1C00001G1788 1.206e-91 328.0 COG2067@1|root,COG3292@1|root,COG2067@2|Bacteria,COG3292@2|Bacteria,2NPQZ@2323|unclassified Bacteria 2|Bacteria I Two component regulator propeller - - - - - - - - - - - - CHB_HEX_C_1,Reg_prop,Reprolysin_5,VCBS YYD3_k127_4028271_1 1379698.RBG1_1C00001G1789 3.988e-88 304.0 COG1572@1|root,COG1572@2|Bacteria,2NP03@2323|unclassified Bacteria 2|Bacteria S Propeptide_C25 porU - - - - - - - - - - - Peptidase_C25 YYD3_k127_4037758_2 457421.CBFG_00127 1.385e-92 311.0 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,2689B@186813|unclassified Clostridiales 186801|Clostridia E Psort location CytoplasmicMembrane, score glnQ1 - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran YYD3_k127_4037758_6 573370.DMR_30950 1.467e-51 191.0 COG0765@1|root,COG0765@2|Bacteria,1MWF0@1224|Proteobacteria,42NEI@68525|delta/epsilon subdivisions,2WJP9@28221|Deltaproteobacteria,2M8HK@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 YYD3_k127_4037758_5 1379698.RBG1_1C00001G1516 5.553e-62 243.0 COG2982@1|root,COG2982@2|Bacteria,2NRT5@2323|unclassified Bacteria 2|Bacteria M AsmA-like C-terminal region - - - ko:K07289,ko:K09800 - - - - ko00000,ko02000 - - - AsmA,AsmA_1,AsmA_2,DUF3971,DctA-YdbH YYD3_k127_4037758_4 555079.Toce_0270 3.175e-77 265.0 COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,249X0@186801|Clostridia,42GDI@68295|Thermoanaerobacterales 186801|Clostridia S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 YYD3_k127_4037758_1 316067.Geob_1979 1.033e-114 381.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,43SZM@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans YYD3_k127_4037758_0 264732.Moth_1652 4.545e-132 432.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales 186801|Clostridia H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 YYD3_k127_4037758_3 1379698.RBG1_1C00001G1523 3.782e-80 290.0 COG4775@1|root,COG4775@2|Bacteria,2NQXR@2323|unclassified Bacteria 2|Bacteria M Surface antigen - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA YYD3_k127_4037758_7 1379698.RBG1_1C00001G1524 8.255e-13 72.0 COG2911@1|root,COG2911@2|Bacteria,2NQ89@2323|unclassified Bacteria 2|Bacteria S TamB, inner membrane protein subunit of TAM complex - - - ko:K07277,ko:K09800 - - - - ko00000,ko02000,ko03029 1.B.33 - - AsmA_2,DUF748,TamB YYD3_k127_4059579_5 880073.Calab_0921 8.887e-23 104.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF4157,FctA,Peptidase_M43 YYD3_k127_4059579_3 292415.Tbd_2287 9.314e-111 362.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VQQJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 YYD3_k127_4059579_1 1122176.KB903587_gene4522 5.467e-164 553.0 COG0739@1|root,COG3291@1|root,COG0739@2|Bacteria,COG3291@2|Bacteria,4PKU5@976|Bacteroidetes,1J0XQ@117747|Sphingobacteriia 976|Bacteroidetes M heme binding - - - - - - - - - - - - - YYD3_k127_4059579_0 518766.Rmar_2560 1.12e-207 680.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NEIE@976|Bacteroidetes,1FIS3@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,OMP_b-brl_3,Plug,TonB_dep_Rec YYD3_k127_4059579_4 311424.DhcVS_273 3.791e-83 285.0 COG0053@1|root,COG0053@2|Bacteria,2G5MK@200795|Chloroflexi,34CPI@301297|Dehalococcoidia 301297|Dehalococcoidia P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer YYD3_k127_4059579_2 1123508.JH636449_gene7422 2.703e-112 410.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg YYD3_k127_4082738_5 1379698.RBG1_1C00001G1368 3.824e-18 94.0 COG4219@1|root,COG4219@2|Bacteria,2NS3V@2323|unclassified Bacteria 2|Bacteria KT Peptidase M56 - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 YYD3_k127_4082738_0 1379698.RBG1_1C00001G1367 1.899e-116 387.0 COG0577@1|root,COG0577@2|Bacteria,2NNN0@2323|unclassified Bacteria 2|Bacteria V COGs COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD3_k127_4082738_3 1379698.RBG1_1C00001G1366 2.029e-94 323.0 COG0577@1|root,COG0577@2|Bacteria,2NQMU@2323|unclassified Bacteria 2|Bacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD3_k127_4082738_1 639030.JHVA01000001_gene86 5.009e-106 348.0 COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD3_k127_4082738_2 1379698.RBG1_1C00001G1364 7.756e-101 344.0 COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family macA - - ko:K02005,ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23,OEP YYD3_k127_4082738_4 215803.DB30_3564 3.175e-34 147.0 COG1538@1|root,COG1538@2|Bacteria,1Q54P@1224|Proteobacteria,42NQV@68525|delta/epsilon subdivisions,2X5KQ@28221|Deltaproteobacteria,2YYUS@29|Myxococcales 28221|Deltaproteobacteria M Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP YYD3_k127_4082738_6 1195236.CTER_1063 5.201e-06 55.0 2EJ6V@1|root,33CY2@2|Bacteria,1VPDN@1239|Firmicutes,24FI9@186801|Clostridia 186801|Clostridia S Yip1 domain - - - - - - - - - - - - Yip1 YYD3_k127_4085418_6 557598.LHK_03146 6.38e-21 101.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,2KPZT@206351|Neisseriales 206351|Neisseriales LU DNA recombination-mediator protein A dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A YYD3_k127_4085418_4 1089550.ATTH01000001_gene767 9.764e-43 163.0 COG1739@1|root,COG1739@2|Bacteria,4NF0D@976|Bacteroidetes,1FJ9B@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Domain of unknown function (DUF1949) yigZ - - - - - - - - - - - UPF0029 YYD3_k127_4085418_2 237368.SCABRO_00251 1.652e-50 191.0 COG0524@1|root,COG0524@2|Bacteria,2IX8I@203682|Planctomycetes 203682|Planctomycetes G pfkB family carbohydrate kinase - - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB YYD3_k127_4085418_5 1191523.MROS_1662 1.896e-33 136.0 COG0671@1|root,COG0671@2|Bacteria 2|Bacteria I phosphatidate phosphatase activity - - 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K01096,ko:K19302 ko00550,ko00564,ko01100,map00550,map00564,map01100 - R02029,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 - - - PAP2 YYD3_k127_4085418_3 580340.Tlie_0418 1.303e-46 173.0 COG2110@1|root,COG2110@2|Bacteria,3TB5Z@508458|Synergistetes 508458|Synergistetes S C-terminal domain of histone - - - - - - - - - - - - Macro YYD3_k127_4085418_1 1379698.RBG1_1C00001G0533 3.423e-118 391.0 COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria 2|Bacteria K acetyltransferase yghO - - - - - - - - - - - Acetyltransf_1 YYD3_k127_4085418_0 1379698.RBG1_1C00001G0532 8.433e-167 535.0 COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria 2|Bacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_4085418_7 391603.FBALC1_16297 6.466e-07 52.0 2DNGD@1|root,32XCZ@2|Bacteria,4NSM2@976|Bacteroidetes,1I4Q7@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_4139055_4 1379698.RBG1_1C00001G1143 1.922e-35 136.0 COG0776@1|root,COG0776@2|Bacteria,2NPU6@2323|unclassified Bacteria 2|Bacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup_1 - - ko:K03530,ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding YYD3_k127_4139055_6 945713.IALB_2216 4.754e-05 45.0 2EIUI@1|root,33CJV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_4139055_2 1379698.RBG1_1C00001G0991 1.083e-56 223.0 COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria 2|Bacteria Q FlgD Ig-like domain - - 3.2.1.136 ko:K15924 - - - - ko00000,ko01000 - GH5 - CBM_3,DUF1735,Laminin_G_3 YYD3_k127_4139055_1 313606.M23134_07555 4.209e-64 235.0 295M7@1|root,2ZSYM@2|Bacteria,4NNH9@976|Bacteroidetes,47UGS@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_4139055_5 5911.EAR82286 4.164e-16 89.0 COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora 5878|Ciliophora GOT TPR Domain containing protein - - - ko:K12600 ko03018,map03018 M00392 - - ko00000,ko00001,ko00002,ko03019 - - - TPR_1,TPR_11,TPR_2,TPR_8 YYD3_k127_4139055_3 926567.TheveDRAFT_1038 2.758e-41 157.0 COG0041@1|root,COG0041@2|Bacteria,3TB8R@508458|Synergistetes 508458|Synergistetes F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC YYD3_k127_4139055_0 760568.Desku_1695 3.021e-150 486.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,2609N@186807|Peptococcaceae 186801|Clostridia F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N YYD3_k127_4160719_0 933262.AXAM01000021_gene456 4.655e-102 352.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF_2,HTH_8,Sigma54_activat YYD3_k127_4160719_1 552811.Dehly_0442 0.0003521 45.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Cytochrom_c3_2 YYD3_k127_4162279_3 1379698.RBG1_1C00001G1256 7.929e-47 175.0 COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria 2|Bacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO YYD3_k127_4162279_1 1379698.RBG1_1C00001G1254 8.414e-112 375.0 COG4796@1|root,COG4796@2|Bacteria,2NPEQ@2323|unclassified Bacteria 2|Bacteria U Secretin and TonB N terminus short domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N YYD3_k127_4162279_5 1121104.AQXH01000001_gene1022 5.902e-12 79.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding sorCs3 - - - - - - - - - - - BNR,Cu_amine_oxidN1,PSII_BNR,Sortilin-Vps10 YYD3_k127_4162279_0 1379698.RBG1_1C00001G1253 4.21e-126 424.0 COG1022@1|root,COG1022@2|Bacteria,2NNTM@2323|unclassified Bacteria 2|Bacteria I COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding YYD3_k127_4162279_2 1121428.DESHY_40040___1 1.67e-87 297.0 COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia,260GP@186807|Peptococcaceae 186801|Clostridia J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B YYD3_k127_4170406_5 1293054.HSACCH_02291 3.359e-08 62.0 COG5581@1|root,COG5581@2|Bacteria 2|Bacteria M regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed pilZ - - - - - - - - - - - PilZ,YcgR_2 YYD3_k127_4170406_0 1379698.RBG1_1C00001G1108 2.491e-94 318.0 COG1191@1|root,COG1191@2|Bacteria,2NPMN@2323|unclassified Bacteria 2|Bacteria K Sigma-70 region 3 - - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 YYD3_k127_4170406_3 1122197.ATWI01000008_gene3254 4.166e-28 124.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RQSP@1236|Gammaproteobacteria,46CPM@72275|Alteromonadaceae 1236|Gammaproteobacteria N COG0455 ATPases involved in chromosome partitioning - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,ParA YYD3_k127_4170406_4 469381.Dpep_0274 4.201e-12 78.0 COG1419@1|root,COG1419@2|Bacteria,3TAHV@508458|Synergistetes 508458|Synergistetes N PFAM GTP-binding signal recognition particle SRP54 G- domain - - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 YYD3_k127_4170406_1 1280671.AUJH01000002_gene2069 5.563e-80 275.0 COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,4BWY1@830|Butyrivibrio 186801|Clostridia NU Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP YYD3_k127_4170572_1 1379698.RBG1_1C00001G0340 7.553e-173 555.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2 YYD3_k127_4170572_2 1379698.RBG1_1C00001G0341 6.356e-141 462.0 COG0766@1|root,COG0766@2|Bacteria,2NNUV@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase YYD3_k127_4170572_4 247490.KSU1_D0285 1.07e-25 113.0 2CA4A@1|root,32RQK@2|Bacteria,2J0BM@203682|Planctomycetes 203682|Planctomycetes S Domain of unknown function (DUF4416) - - - - - - - - - - - - DUF4416 YYD3_k127_4170572_3 1459636.NTE_00759 7.118e-37 146.0 COG1027@1|root,COG1670@1|root,arCOG00842@2157|Archaea,arCOG01750@2157|Archaea,41S9C@651137|Thaumarchaeota 651137|Thaumarchaeota E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 YYD3_k127_4170572_0 1379698.RBG1_1C00001G0334 2.364e-259 808.0 COG2987@1|root,COG2987@2|Bacteria,2NP09@2323|unclassified Bacteria 2|Bacteria E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016153,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_0688 Urocanase,Urocanase_C,Urocanase_N YYD3_k127_4174697_3 1173264.KI913949_gene709 6.148e-49 182.0 COG0235@1|root,COG0235@2|Bacteria,1G2EA@1117|Cyanobacteria,1H8JN@1150|Oscillatoriales 1117|Cyanobacteria E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) mtnB - 4.2.1.109 ko:K08964 ko00270,ko01100,map00270,map01100 M00034 R07392 RC01939 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II YYD3_k127_4174697_1 1173264.KI913949_gene37 2.995e-70 243.0 COG1791@1|root,COG1791@2|Bacteria,1G274@1117|Cyanobacteria 1117|Cyanobacteria S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway mtnD - 1.13.11.53,1.13.11.54 ko:K08967 ko00270,ko01100,map00270,map01100 M00034 R07363,R07364 RC01866,RC02018,RC02118 ko00000,ko00001,ko00002,ko01000 - - - ARD YYD3_k127_4174697_2 269084.syc2102_c 1.024e-67 238.0 COG4229@1|root,COG4229@2|Bacteria,1G59P@1117|Cyanobacteria,1H3Y4@1129|Synechococcus 1117|Cyanobacteria F Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) mtnC - 3.1.3.77 ko:K09880 ko00270,ko01100,map00270,map01100 M00034 R07395 RC02779 ko00000,ko00001,ko00002,ko01000 - - - HAD_2,Hydrolase YYD3_k127_4174697_0 1254432.SCE1572_31200 4.076e-104 351.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42N1P@68525|delta/epsilon subdivisions,2WM2V@28221|Deltaproteobacteria,2YU4D@29|Myxococcales 28221|Deltaproteobacteria E Aminotransferase - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_4174697_4 869210.Marky_1400 6.572e-12 77.0 2FC4C@1|root,34489@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_417527_3 1379698.RBG1_1C00001G0150 1.184e-87 292.0 COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria 2|Bacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N YYD3_k127_417527_8 373903.Hore_17830 3.708e-27 117.0 COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia,3WATA@53433|Halanaerobiales 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP YYD3_k127_417527_7 1379698.RBG1_1C00001G0148 2.507e-36 144.0 COG0711@1|root,COG0711@2|Bacteria,2NQ34@2323|unclassified Bacteria 2|Bacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B YYD3_k127_417527_9 1379698.RBG1_1C00001G0147 1.178e-25 108.0 COG0636@1|root,COG0636@2|Bacteria,2NQ21@2323|unclassified Bacteria 2|Bacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C YYD3_k127_417527_5 1379698.RBG1_1C00001G0146 1.387e-72 254.0 COG0356@1|root,COG0356@2|Bacteria,2NPRQ@2323|unclassified Bacteria 2|Bacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A YYD3_k127_417527_11 1379698.RBG1_1C00001G0145 2.198e-17 87.0 2EPKR@1|root,33H7C@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_417527_12 765952.PUV_23630 2.293e-09 63.0 2EQQP@1|root,33IAK@2|Bacteria,2JGJU@204428|Chlamydiae 204428|Chlamydiae S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 YYD3_k127_417527_10 436114.SYO3AOP1_0137 2.128e-23 108.0 COG1472@1|root,COG1472@2|Bacteria,2G52S@200783|Aquificae 200783|Aquificae G Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 YYD3_k127_417527_4 639282.DEFDS_1066 8.22e-82 278.0 COG0410@1|root,COG0410@2|Bacteria,2GEK0@200930|Deferribacteres 200930|Deferribacteres E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran YYD3_k127_417527_0 945713.IALB_0420 1.089e-193 613.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I YYD3_k127_417527_1 452637.Oter_1447 1.223e-150 484.0 COG1294@1|root,COG1294@2|Bacteria,46UN7@74201|Verrucomicrobia,3K8IE@414999|Opitutae 414999|Opitutae C Cytochrome BD ubiquinol oxidase subunit II - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II YYD3_k127_417527_2 1379698.RBG1_1C00001G1819 1.152e-116 409.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_417527_6 1379698.RBG1_1C00001G1819 2.707e-57 218.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_4200677_6 357808.RoseRS_1917 4.236e-47 171.0 COG0798@1|root,COG0798@2|Bacteria,2G5ZH@200795|Chloroflexi,37708@32061|Chloroflexia 32061|Chloroflexia P Sodium Bile acid symporter family - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF YYD3_k127_4200677_4 929556.Solca_3634 5.379e-86 291.0 COG0500@1|root,COG2226@2|Bacteria,4NEUC@976|Bacteroidetes,1IP66@117747|Sphingobacteriia 976|Bacteroidetes Q Methylase involved in ubiquinone menaquinone biosynthesis arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 YYD3_k127_4200677_7 1267211.KI669560_gene110 3.027e-34 136.0 COG0640@1|root,COG0640@2|Bacteria,4NQK3@976|Bacteroidetes,1ITK5@117747|Sphingobacteriia 976|Bacteroidetes K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 YYD3_k127_4200677_9 1051985.l11_07360 5.434e-07 60.0 COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,2VXV9@28216|Betaproteobacteria,2KSB6@206351|Neisseriales 206351|Neisseriales C Heavy metal-associated domain protein - - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA YYD3_k127_4200677_5 1379698.RBG1_1C00001G0462 6.016e-75 262.0 COG2067@1|root,COG2067@2|Bacteria,2NPVZ@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - YYD3_k127_4200677_8 330214.NIDE2676 3.25e-25 109.0 COG4095@1|root,COG4095@2|Bacteria,3J0UA@40117|Nitrospirae 40117|Nitrospirae S PQ loop repeat - - - ko:K15383 - - - - ko00000,ko02000 9.A.58.2 - - PQ-loop YYD3_k127_4200677_0 323261.Noc_1458 1.049e-164 524.0 COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria,1SYTE@1236|Gammaproteobacteria,1X0JZ@135613|Chromatiales 135613|Chromatiales U beta Propeller - - - - - - - - - - - - PD40 YYD3_k127_4200677_3 1379698.RBG1_1C00001G0346 2.297e-91 310.0 COG0341@1|root,COG0341@2|Bacteria,2NP4P@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG YYD3_k127_4200677_1 880073.Calab_0027 1.811e-98 342.0 COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG YYD3_k127_4200677_2 237368.SCABRO_03474 2.722e-96 341.0 COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes 203682|Planctomycetes S PFAM Peptidase M16 inactive domain - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C YYD3_k127_4208017_0 945713.IALB_3203 4.021e-38 157.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria 2|Bacteria M membrane organization plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin YYD3_k127_4244648_1 1379698.RBG1_1C00001G0122 9.087e-75 256.0 COG1070@1|root,COG1070@2|Bacteria,2NP2A@2323|unclassified Bacteria 2|Bacteria G MutL protein - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N,MutL YYD3_k127_4244648_0 1379698.RBG1_1C00001G0120 7.815e-147 473.0 28II6@1|root,2Z8JB@2|Bacteria,2NNT1@2323|unclassified Bacteria 2|Bacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - YYD3_k127_4244648_2 1379698.RBG1_1C00001G0497 6.594e-40 158.0 COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria 2|Bacteria U MotA/TolQ/ExbB proton channel family tolQ - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB YYD3_k127_4244648_3 1331060.RLDS_13940 4.03e-23 104.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,2K53V@204457|Sphingomonadales 204457|Sphingomonadales U Biopolymer transport protein tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD YYD3_k127_4261936_1 891968.Anamo_1218 3.926e-23 110.0 COG3206@1|root,COG3206@2|Bacteria,3TAZ7@508458|Synergistetes 508458|Synergistetes M PFAM lipopolysaccharide biosynthesis protein - - - - - - - - - - - - GNVR,Wzz YYD3_k127_4261936_0 745014.OMB55_00004060 3.743e-25 120.0 COG1596@1|root,COG1596@2|Bacteria,1PK0T@1224|Proteobacteria,1SXFX@1236|Gammaproteobacteria,1JBNW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB YYD3_k127_4261936_2 626939.HMPREF9443_01678 2.521e-08 56.0 COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,4H25Q@909932|Negativicutes 909932|Negativicutes F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase YYD3_k127_4273512_6 903818.KI912268_gene3171 1.689e-22 97.0 COG0227@1|root,COG0227@2|Bacteria,3Y5KC@57723|Acidobacteria 57723|Acidobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 YYD3_k127_4273512_1 224324.aq_298 7.128e-148 479.0 COG0172@1|root,COG0172@2|Bacteria,2G3RF@200783|Aquificae 200783|Aquificae J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b YYD3_k127_4273512_2 1379698.RBG1_1C00001G1544 1.838e-105 358.0 COG4191@1|root,COG4191@2|Bacteria,2NPC5@2323|unclassified Bacteria 2|Bacteria T Integral membrane sensor signal transduction histidine kinase vicK - 2.1.1.80,2.7.13.3,3.1.1.61 ko:K07709,ko:K13924 ko02020,ko02030,map02020,map02030 M00499,M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA YYD3_k127_4273512_0 1379698.RBG1_1C00001G1545 7.716e-181 579.0 COG0745@1|root,COG0745@2|Bacteria,2NNXK@2323|unclassified Bacteria 2|Bacteria KT PglZ domain - - - - - - - - - - - - PglZ,Response_reg YYD3_k127_4273512_4 1410631.JHWZ01000001_gene964 5.803e-30 123.0 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,27MWC@186928|unclassified Lachnospiraceae 186801|Clostridia S Threonylcarbamoyl adenosine biosynthesis protein TsaE ydiB - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE YYD3_k127_4273512_7 1321781.HMPREF1985_00642 3.233e-20 99.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4H47Z@909932|Negativicutes 909932|Negativicutes O Universal bacterial protein YeaZ yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 YYD3_k127_4273512_5 1121335.Clst_2533 2.603e-27 118.0 COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,3WKHF@541000|Ruminococcaceae 186801|Clostridia K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 YYD3_k127_4273512_3 1379698.RBG1_1C00001G1549 3.237e-54 194.0 COG0777@1|root,COG0777@2|Bacteria,2NP40@2323|unclassified Bacteria 2|Bacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iJN678.accD,iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Carboxyl_trans YYD3_k127_4326697_1 251221.35211027 2.806e-125 412.0 COG0438@1|root,COG0438@2|Bacteria,1G8EM@1117|Cyanobacteria 2|Bacteria M Domain of unknown function (DUF1972) rgpA - - ko:K12996 - - - - ko00000,ko01000,ko01003,ko01005 - GT4 - DUF1972,Glyco_trans_1_4,Glycos_transf_1 YYD3_k127_4326697_2 319225.Plut_1888 2.624e-15 88.0 COG3206@1|root,COG3206@2|Bacteria 2|Bacteria M extracellular polysaccharide biosynthetic process - - 3.1.21.3 ko:K01153,ko:K05789,ko:K07011,ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01005,ko02000,ko02048 8.A.3.1 - - GNVR,Wzz YYD3_k127_4326697_0 1519464.HY22_06785 2.531e-225 713.0 COG3808@1|root,COG3808@2|Bacteria,1FD6P@1090|Chlorobi 1090|Chlorobi C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase YYD3_k127_4327917_2 1191523.MROS_1206 3.486e-106 348.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family pruA - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh YYD3_k127_4327917_5 863365.XHC_4158 9.58e-39 148.0 COG1607@1|root,COG1607@2|Bacteria,1RHNU@1224|Proteobacteria,1S4SW@1236|Gammaproteobacteria,1XD3I@135614|Xanthomonadales 135614|Xanthomonadales I Thioesterase superfamily VL23_09840 - - - - - - - - - - - 4HBT YYD3_k127_4327917_4 983917.RGE_38700 1.564e-39 151.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase,Glyoxalase_2 YYD3_k127_4327917_0 891968.Anamo_1586 1.44e-244 776.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,3TA4P@508458|Synergistetes 508458|Synergistetes G PFAM glycosyl transferase family 20 - - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase YYD3_k127_4327917_3 592015.HMPREF1705_00166 3.692e-66 232.0 COG0438@1|root,COG0438@2|Bacteria,3TC5G@508458|Synergistetes 508458|Synergistetes M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - YYD3_k127_4327917_1 891968.Anamo_1584 2.57e-199 627.0 COG0438@1|root,COG0438@2|Bacteria,3TAFG@508458|Synergistetes 508458|Synergistetes H PFAM glycosyl transferase group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 YYD3_k127_4330053_1 1379698.RBG1_1C00001G0100 1.349e-59 215.0 COG0325@1|root,COG0325@2|Bacteria,2NPEW@2323|unclassified Bacteria 2|Bacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis ylmE GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - ko:K06997 - - - - ko00000 - - - Ala_racemase_N YYD3_k127_4330053_3 292459.STH1230 8.212e-11 74.0 COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,24MM3@186801|Clostridia 186801|Clostridia D PFAM DivIVA family protein divIVA - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA YYD3_k127_4330053_2 661478.OP10G_0268 6.706e-23 103.0 COG3795@1|root,COG3795@2|Bacteria 2|Bacteria F YCII-related domain - - - - - - - - - - - - DoxX_2,YCII YYD3_k127_4330053_0 1396418.BATQ01000056_gene225 4.856e-113 381.0 COG4941@1|root,COG4941@2|Bacteria,46SEY@74201|Verrucomicrobia,2IV8H@203494|Verrucomicrobiae 203494|Verrucomicrobiae K Sigma-70 region 2 - - - - - - - - - - - - Sigma70_r2 YYD3_k127_4330053_4 1410653.JHVC01000001_gene1764 7.151e-10 59.0 COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,36E70@31979|Clostridiaceae 186801|Clostridia C flavodoxin nitric oxide synthase fprA1 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0017144,GO:0022900,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050664,GO:0055114,GO:0072592,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B YYD3_k127_4332460_0 555079.Toce_2076 1.492e-44 166.0 COG0454@1|root,COG0456@2|Bacteria,1V6D6@1239|Firmicutes,24KC1@186801|Clostridia,42GT3@68295|Thermoanaerobacterales 186801|Clostridia K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 YYD3_k127_4332460_1 1379698.RBG1_1C00001G0460 1.409e-11 65.0 COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria 2|Bacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon YYD3_k127_4374679_3 1379698.RBG1_1C00001G1759 1.69e-102 340.0 COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria 2|Bacteria O prohibitin homologues hflC - - - - - - - - - - - Band_7 YYD3_k127_4374679_4 289376.THEYE_A0592 2.527e-99 342.0 COG1030@1|root,COG1030@2|Bacteria,3J0WF@40117|Nitrospirae 40117|Nitrospirae O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD YYD3_k127_4374679_2 1379698.RBG1_1C00001G1761 3.658e-108 369.0 COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 YYD3_k127_4374679_0 1379698.RBG1_1C00001G1762 5.368e-130 437.0 COG3276@1|root,COG3276@2|Bacteria,2NNQU@2323|unclassified Bacteria 2|Bacteria J Elongation factor SelB, winged helix selB GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112 - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 YYD3_k127_4374679_1 1379698.RBG1_1C00001G1763 9.878e-109 367.0 COG1921@1|root,COG1921@2|Bacteria,2NNT6@2323|unclassified Bacteria 2|Bacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006 Se-cys_synth_N,SelA YYD3_k127_4374679_5 1379698.RBG1_1C00001G0436 2.496e-67 241.0 COG2234@1|root,COG2234@2|Bacteria,2NP7A@2323|unclassified Bacteria 2|Bacteria S Peptidase M28 ywaD - - - - - - - - - - - Peptidase_M28 YYD3_k127_4374679_6 1379698.RBG1_1C00001G0435 2.142e-50 200.0 COG1747@1|root,COG1747@2|Bacteria,2NP33@2323|unclassified Bacteria 2|Bacteria M methyltransferase greA - - - - - - - - - - - GreA_GreB,GreA_GreB_N,SprA_N YYD3_k127_4390271_1 1449126.JQKL01000031_gene1144 6.174e-83 284.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,267WS@186813|unclassified Clostridiales 186801|Clostridia I Enoyl-CoA hydratase/isomerase crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 YYD3_k127_4390271_0 1047013.AQSP01000142_gene242 4.107e-122 397.0 COG2511@1|root,COG2511@2|Bacteria 2|Bacteria J GatB/GatE catalytic domain - - - - - - - - - - - - GatB_N YYD3_k127_4400293_2 1380384.JADN01000004_gene2205 1.574e-05 49.0 COG1842@1|root,COG1842@2|Bacteria,4PM86@976|Bacteroidetes,1IJM9@117743|Flavobacteriia 976|Bacteroidetes KT Phage shock protein A - - - - - - - - - - - - DUF4175 YYD3_k127_4400293_1 1519464.HY22_13445 2.703e-31 125.0 COG0109@1|root,COG0109@2|Bacteria 2|Bacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA YYD3_k127_4400293_0 330214.NIDE1937 0.0 1547.0 COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD YYD3_k127_4433262_3 1123054.KB907709_gene788 9.447e-10 65.0 2FA2R@1|root,342BQ@2|Bacteria,1NZGH@1224|Proteobacteria,1SQPP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_4433262_2 1225184.ALXE01000044_gene627 3.244e-22 113.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,3VXUG@53335|Pantoea 1236|Gammaproteobacteria P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB btuB GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696 Plug,TonB_dep_Rec YYD3_k127_4433262_1 443143.GM18_2043 6.872e-91 315.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 YYD3_k127_4433262_0 56780.SYN_01995 2.208e-91 311.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD3_k127_4435505_2 1379698.RBG1_1C00001G1085 9.676e-32 124.0 COG2109@1|root,COG2109@2|Bacteria,2NPNR@2323|unclassified Bacteria 2|Bacteria H ATP:corrinoid adenosyltransferase BtuR/CobO/CobP - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR YYD3_k127_4435505_3 316067.Geob_2631 7.699e-24 106.0 COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,43UWZ@69541|Desulfuromonadales 28221|Deltaproteobacteria K transcriptional regulator, Rrf2 family - - - - - - - - - - - - Rrf2 YYD3_k127_4435505_1 671143.DAMO_1182 2.047e-72 248.0 COG0717@1|root,COG0717@2|Bacteria,2NQ5G@2323|unclassified Bacteria 2|Bacteria F Belongs to the dCTP deaminase family dcd GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase YYD3_k127_4435505_0 665571.STHERM_c16630 0.0 1590.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2J5QV@203691|Spirochaetes 203691|Spirochaetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C YYD3_k127_4435505_5 1239962.C943_03877 1.213e-16 91.0 COG0823@1|root,COG0823@2|Bacteria,4NEPF@976|Bacteroidetes,47NVJ@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - CarbopepD_reg_2,CarboxypepD_reg,PD40 YYD3_k127_4435505_4 243231.GSU0332 5.779e-23 100.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,43RYN@69541|Desulfuromonadales 28221|Deltaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N YYD3_k127_4438689_3 1120966.AUBU01000006_gene3405 5.262e-11 72.0 COG4447@1|root,COG4447@2|Bacteria,4NRP7@976|Bacteroidetes,47U6K@768503|Cytophagia 976|Bacteroidetes S Photosynthesis system II assembly factor YCF48 - - - - - - - - - - - - PSII_BNR YYD3_k127_4438689_0 1266998.ATUJ01000001_gene2645 5.661e-24 111.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,2PUUC@265|Paracoccus 28211|Alphaproteobacteria D ATPases associated with a variety of cellular activities ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran YYD3_k127_4438689_2 269799.Gmet_1855 1.807e-16 91.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,43BBA@68525|delta/epsilon subdivisions,2X6QG@28221|Deltaproteobacteria,43T0S@69541|Desulfuromonadales 28221|Deltaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX YYD3_k127_4438689_1 1297742.A176_05290 6.207e-17 94.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,42N32@68525|delta/epsilon subdivisions,2WKBN@28221|Deltaproteobacteria,2YVR8@29|Myxococcales 28221|Deltaproteobacteria D Peptidase family M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23,SH3_3 YYD3_k127_4438689_4 717605.Theco_3740 2.124e-07 57.0 COG0470@1|root,COG0470@2|Bacteria,1TRVS@1239|Firmicutes,4HA3T@91061|Bacilli,26Q9Y@186822|Paenibacillaceae 91061|Bacilli L DNA polymerase III holB GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C YYD3_k127_4450918_4 1191523.MROS_0520 3.892e-22 113.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - Porin_2 YYD3_k127_4450918_5 394503.Ccel_1550 7.754e-05 53.0 COG3325@1|root,COG3325@2|Bacteria,1UPJ7@1239|Firmicutes,24D95@186801|Clostridia,36EAZ@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 18 family - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - 1-cysPrx_C,AhpC-TSA,Dockerin_1,Glyco_hydro_18 YYD3_k127_4450918_0 195250.CM001776_gene1952 9.169e-143 463.0 COG2223@1|root,COG2223@2|Bacteria 2|Bacteria P nitrite transmembrane transporter activity - - - - - - - - - - - - MFS_1 YYD3_k127_4450918_3 671143.DAMO_0437 6.617e-23 104.0 2EBKA@1|root,335KQ@2|Bacteria,2NRDT@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_4450918_1 1094980.Mpsy_2655 1.985e-127 419.0 COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia 224756|Methanomicrobia P Citrate transporter - - - - - - - - - - - - CitMHS YYD3_k127_4450918_2 338963.Pcar_2713 1.694e-52 188.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,43SCR@69541|Desulfuromonadales 28221|Deltaproteobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA YYD3_k127_4479836_5 1379698.RBG1_1C00001G0172 1.122e-46 177.0 COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria 2|Bacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C YYD3_k127_4479836_2 1379698.RBG1_1C00001G0643 9.766e-118 386.0 COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria 2|Bacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2848 Pribosyl_synth,Pribosyltran_N YYD3_k127_4479836_7 1399774.JDWH01000007_gene1591 0.0004185 47.0 2EFWG@1|root,339NR@2|Bacteria,1NIWH@1224|Proteobacteria,1SHRN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_4479836_6 1379698.RBG1_1C00001G0639 6.076e-28 116.0 COG2088@1|root,COG2088@2|Bacteria,2NQ05@2323|unclassified Bacteria 2|Bacteria D SpoVG spoVG - - ko:K06412 - - - - ko00000 - - - SpoVG YYD3_k127_4479836_4 1297581.H919_10843 2.107e-52 196.0 COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,4HAV8@91061|Bacilli,21W08@150247|Anoxybacillus 91061|Bacilli I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.29 - iYO844.BSU00460 GHMP_kinases_C,GHMP_kinases_N YYD3_k127_4479836_0 344747.PM8797T_17839 0.0 1157.0 COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes 203682|Planctomycetes C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C YYD3_k127_4479836_1 521674.Plim_2153 3.767e-133 432.0 COG0191@1|root,COG0191@2|Bacteria,2IYZ9@203682|Planctomycetes 203682|Planctomycetes G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase YYD3_k127_4479836_3 517418.Ctha_0507 3.555e-83 283.0 COG0404@1|root,COG0404@2|Bacteria,1FDEA@1090|Chlorobi 1090|Chlorobi E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C YYD3_k127_4493750_0 1379698.RBG1_1C00001G1741 1.926e-156 499.0 COG1459@1|root,COG1459@2|Bacteria,2NP2J@2323|unclassified Bacteria 2|Bacteria U Type II secretion system (T2SS), protein F pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF YYD3_k127_4493750_1 1379698.RBG1_1C00001G1740 9.682e-134 445.0 COG3852@1|root,COG3852@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9 YYD3_k127_4493750_4 1191523.MROS_0172 1.622e-19 103.0 COG0760@1|root,COG0760@2|Bacteria 2|Bacteria O peptidyl-prolyl cis-trans isomerase activity - - 5.2.1.8 ko:K03769,ko:K03771 - - - - ko00000,ko01000,ko03110 - - - OmpA,Rotamase,Rotamase_2,Rotamase_3 YYD3_k127_4493750_3 1379698.RBG1_1C00001G0464 1.693e-41 161.0 COG0170@1|root,COG0170@2|Bacteria,2NQ5M@2323|unclassified Bacteria 2|Bacteria I dolichyl monophosphate biosynthetic process sec59 - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf YYD3_k127_4493750_5 378806.STAUR_7588 4.62e-16 79.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WQ3M@28221|Deltaproteobacteria,2Z1Q1@29|Myxococcales 28221|Deltaproteobacteria K Cold-shock protein cspE - - ko:K03704 - - - - ko00000,ko03000 - - - CSD YYD3_k127_4493750_2 118163.Ple7327_3743 3.317e-97 325.0 COG2008@1|root,COG2008@2|Bacteria,1G4PN@1117|Cyanobacteria 1117|Cyanobacteria E Threonine aldolase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase YYD3_k127_4508227_5 1123288.SOV_1c03230 3.757e-31 131.0 COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,4H38C@909932|Negativicutes 909932|Negativicutes O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH YYD3_k127_4508227_3 1220534.B655_1754 3.129e-40 156.0 COG3467@1|root,arCOG00520@2157|Archaea,2Y26T@28890|Euryarchaeota,23PV6@183925|Methanobacteria 183925|Methanobacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 YYD3_k127_4508227_0 340099.Teth39_1216 7.441e-120 395.0 COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,42FDK@68295|Thermoanaerobacterales 186801|Clostridia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06430 GcpE YYD3_k127_4508227_1 357808.RoseRS_2711 2.662e-84 287.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,2G64U@200795|Chloroflexi,374ZG@32061|Chloroflexia 32061|Chloroflexia P YidE YbjL duplication domain protein - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C YYD3_k127_4508227_2 326427.Cagg_0607 6.245e-57 208.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,2G64U@200795|Chloroflexi,374ZG@32061|Chloroflexia 32061|Chloroflexia P YidE YbjL duplication domain protein - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C YYD3_k127_4508227_4 525373.HMPREF0766_10920 1.001e-34 136.0 COG0586@1|root,COG0586@2|Bacteria,4NHQA@976|Bacteroidetes,1IR8N@117747|Sphingobacteriia 976|Bacteroidetes S PFAM SNARE associated Golgi protein - - - ko:K03975 - - - - ko00000 - - - SNARE_assoc YYD3_k127_4541859_3 1379698.RBG1_1C00001G1172 7.833e-53 191.0 COG0503@1|root,COG0503@2|Bacteria,2NPGX@2323|unclassified Bacteria 2|Bacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - PRTase_2,Pribosyltran,TRSP YYD3_k127_4541859_9 518766.Rmar_1812 1.596e-18 89.0 COG1254@1|root,COG1254@2|Bacteria,4NVB4@976|Bacteroidetes,1FJMR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Acylphosphatase acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase YYD3_k127_4541859_6 1379698.RBG1_1C00001G1174 3.206e-41 157.0 COG1611@1|root,COG1611@2|Bacteria,2NPJB@2323|unclassified Bacteria 2|Bacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DNA_processg_A,Lysine_decarbox YYD3_k127_4541859_2 648996.Theam_1712 6.005e-63 228.0 COG0496@1|root,COG0496@2|Bacteria,2G3WU@200783|Aquificae 200783|Aquificae S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE YYD3_k127_4541859_4 1379698.RBG1_1C00001G1176 6.78e-49 184.0 COG1216@1|root,COG1216@2|Bacteria,2NS4X@2323|unclassified Bacteria 2|Bacteria S Glycosyl transferase family 2 XK27_08075 - - - - - - - - - - - DUF2062,Glycos_transf_2,GtrA,Lip_A_acyltrans YYD3_k127_4541859_10 59538.XP_005979423.1 0.0004857 43.0 COG0277@1|root,KOG1231@2759|Eukaryota,38FXH@33154|Opisthokonta,3BEEV@33208|Metazoa,3CRTP@33213|Bilateria,4801S@7711|Chordata,492UT@7742|Vertebrata,3JDRF@40674|Mammalia,4J43Y@91561|Cetartiodactyla 33208|Metazoa C dehydrogenase - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4,Fer4_8 YYD3_k127_4541859_8 1379698.RBG1_1C00001G1177 3.302e-19 96.0 COG0789@1|root,COG0789@2|Bacteria,2NQ3P@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix, mercury resistance ycgE - - ko:K19591,ko:K22491 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR_1 YYD3_k127_4541859_1 1379698.RBG1_1C00001G1178 5.341e-101 340.0 COG0240@1|root,COG0240@2|Bacteria,2NP1N@2323|unclassified Bacteria 2|Bacteria I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N YYD3_k127_4541859_5 269799.Gmet_3020 7.773e-42 162.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,42QQP@68525|delta/epsilon subdivisions,2WMZE@28221|Deltaproteobacteria,43UMJ@69541|Desulfuromonadales 28221|Deltaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf YYD3_k127_4541859_7 1379698.RBG1_1C00001G1567 1.907e-37 146.0 COG0203@1|root,COG0203@2|Bacteria,2NPYQ@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein L17 rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02879,ko:K16193 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 YYD3_k127_4541859_0 1379698.RBG1_1C00001G1568 5.256e-125 408.0 COG0202@1|root,COG0202@2|Bacteria,2NNQQ@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L YYD3_k127_4554134_6 1121920.AUAU01000012_gene2677 9.595e-53 193.0 COG0281@1|root,COG0281@2|Bacteria,3Y43V@57723|Acidobacteria 57723|Acidobacteria C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic YYD3_k127_4554134_2 289376.THEYE_A0982 8.402e-86 292.0 COG2084@1|root,COG2084@2|Bacteria,3J0R5@40117|Nitrospirae 40117|Nitrospirae I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 YYD3_k127_4554134_3 316274.Haur_0493 2.119e-72 259.0 COG1902@1|root,COG1902@2|Bacteria,2G7MP@200795|Chloroflexi,3760K@32061|Chloroflexia 32061|Chloroflexia C PFAM NADH flavin oxidoreductase NADH oxidase - - 1.5.8.1,1.5.8.2 ko:K00317 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R01588,R02511 RC00185,RC00556,RC00557,RC00732 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 YYD3_k127_4554134_10 926560.KE387023_gene3760 5.808e-27 115.0 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - CHRD,Malectin YYD3_k127_4554134_9 1026882.MAMP_02098 5.406e-38 147.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1RNXM@1236|Gammaproteobacteria,461HI@72273|Thiotrichales 72273|Thiotrichales S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF,QueF_N YYD3_k127_4554134_1 1125863.JAFN01000001_gene2317 3.66e-87 299.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_3075 QueC YYD3_k127_4554134_7 1237149.C900_03709 7.216e-42 165.0 COG0602@1|root,COG0602@2|Bacteria,4NESC@976|Bacteroidetes,47MB1@768503|Cytophagia 976|Bacteroidetes H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14,Radical_SAM YYD3_k127_4554134_8 579138.Zymop_0446 1.004e-38 147.0 COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,2VG5E@28211|Alphaproteobacteria,2K4TA@204457|Sphingomonadales 204457|Sphingomonadales H PFAM 6-pyruvoyl tetrahydropterin synthase and - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS YYD3_k127_4554134_15 1134474.O59_001444 0.0001551 51.0 COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1T4K6@1236|Gammaproteobacteria,1FGY3@10|Cellvibrio 1236|Gammaproteobacteria KLT Sulfatase-modifying factor enzyme 1 ppkA - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - FGE-sulfatase,PEGA,Pkinase YYD3_k127_4554134_5 340177.Cag_1137 3.573e-67 237.0 COG1194@1|root,COG1194@2|Bacteria,1FD5V@1090|Chlorobi 1090|Chlorobi L HhH-GPD family - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD YYD3_k127_4554134_16 1379281.AVAG01000075_gene1515 0.0005105 52.0 COG3307@1|root,COG3307@2|Bacteria,1NGAP@1224|Proteobacteria,42XF9@68525|delta/epsilon subdivisions 1224|Proteobacteria M O-Antigen ligase - - - ko:K02847 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 - - Wzy_C YYD3_k127_4554134_4 525897.Dbac_2942 2.227e-67 256.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_4554134_11 517418.Ctha_1876 1.955e-14 81.0 COG4577@1|root,COG4577@2|Bacteria,1FFCZ@1090|Chlorobi 1090|Chlorobi CQ BMC - - - - - - - - - - - - BMC YYD3_k127_4554134_0 857293.CAAU_0042 3.405e-139 449.0 COG0451@1|root,COG0451@2|Bacteria,1TSUN@1239|Firmicutes,2485S@186801|Clostridia,36FJ8@31979|Clostridiaceae 186801|Clostridia M RmlD substrate binding domain - - - - - - - - - - - - Epimerase YYD3_k127_4554134_13 1047013.AQSP01000059_gene2096 4.605e-10 66.0 COG0736@1|root,COG0736@2|Bacteria,2NPTD@2323|unclassified Bacteria 2|Bacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7,4.2.1.136 ko:K00997,ko:K17758 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS,Carb_kinase YYD3_k127_4575563_5 1379698.RBG1_1C00001G0114 1.415e-08 57.0 29ZH8@1|root,30MGZ@2|Bacteria,2NQ83@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_4575563_3 1379698.RBG1_1C00001G0113 5.713e-64 230.0 28MYQ@1|root,2ZB5K@2|Bacteria,2NPC8@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD3_k127_4575563_4 1379698.RBG1_1C00001G0112 1.58e-55 203.0 2ANS9@1|root,31DS7@2|Bacteria,2NQ66@2323|unclassified Bacteria 2|Bacteria S Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - YYD3_k127_4575563_2 1519464.HY22_02585 3.906e-91 310.0 COG1209@1|root,COG1209@2|Bacteria,1FD8Z@1090|Chlorobi 1090|Chlorobi M Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase YYD3_k127_4575563_0 1379698.RBG1_1C00001G1854 5.251e-174 552.0 COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria 2|Bacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N YYD3_k127_4575563_1 1379698.RBG1_1C00001G1855 3.034e-141 460.0 COG0499@1|root,COG0499@2|Bacteria,2NNQE@2323|unclassified Bacteria 2|Bacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD YYD3_k127_4585708_2 1379698.RBG1_1C00001G1482 1.478e-75 267.0 COG1193@1|root,COG1193@2|Bacteria,2NNS1@2323|unclassified Bacteria 2|Bacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr YYD3_k127_4585708_0 1379698.RBG1_1C00001G1481 1.037e-126 425.0 COG0358@1|root,COG0358@2|Bacteria,2NNNJ@2323|unclassified Bacteria 2|Bacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 YYD3_k127_4585708_1 518766.Rmar_0370 1.147e-92 325.0 COG0497@1|root,COG0497@2|Bacteria,4NE3I@976|Bacteroidetes,1FIR2@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N YYD3_k127_4585708_3 1123288.SOV_5c05070 2.3e-53 200.0 COG2378@1|root,COG2378@2|Bacteria,1TS78@1239|Firmicutes,4H45V@909932|Negativicutes 909932|Negativicutes K WYL domain - - - - - - - - - - - - HTH_11,WYL YYD3_k127_4585708_5 880073.Calab_3127 1.13e-23 117.0 2C4MF@1|root,300D5@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_4585708_4 880073.Calab_3128 1.502e-24 117.0 2API0@1|root,31EM0@2|Bacteria,2NRTE@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_4595487_1 1232410.KI421413_gene835 1.259e-24 110.0 COG1633@1|root,COG1633@2|Bacteria,1RM4Q@1224|Proteobacteria,42SRM@68525|delta/epsilon subdivisions,2WP47@28221|Deltaproteobacteria,43SJC@69541|Desulfuromonadales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD3_k127_4595487_0 340177.Cag_1780 1.036e-155 503.0 COG0205@1|root,COG0205@2|Bacteria,1FEH2@1090|Chlorobi 1090|Chlorobi G PFAM phosphofructokinase - - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK YYD3_k127_4602271_1 1265505.ATUG01000001_gene4024 1.237e-118 385.0 COG1013@1|root,COG1013@2|Bacteria,1N0HY@1224|Proteobacteria,42MTM@68525|delta/epsilon subdivisions,2WJS6@28221|Deltaproteobacteria,2MIRW@213118|Desulfobacterales 28221|Deltaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C YYD3_k127_4602271_0 1232437.KL661988_gene235 4.956e-144 464.0 COG0674@1|root,COG0674@2|Bacteria,1MWCI@1224|Proteobacteria,42NJY@68525|delta/epsilon subdivisions,2WIW3@28221|Deltaproteobacteria,2MHPN@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyruvate:ferredoxin oxidoreductase core domain II vorA - 1.2.7.11,1.2.7.3,1.2.7.7 ko:K00174,ko:K00186 ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197,R07160,R08566,R08567 RC00004,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1307 PFOR_II,POR_N YYD3_k127_4602271_4 521045.Kole_2161 1.167e-19 90.0 COG1146@1|root,COG1146@2|Bacteria,2GDEK@200918|Thermotogae 200918|Thermotogae C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4 YYD3_k127_4602271_3 1121396.KB893071_gene1265 1.73e-54 199.0 COG0489@1|root,COG0489@2|Bacteria,1R6AC@1224|Proteobacteria,42NTJ@68525|delta/epsilon subdivisions,2WM95@28221|Deltaproteobacteria,2MJ5Z@213118|Desulfobacterales 28221|Deltaproteobacteria D protein tyrosine kinase activity - - - - - - - - - - - - - YYD3_k127_4602271_2 1162668.LFE_1804 4.576e-78 268.0 COG0372@1|root,COG0372@2|Bacteria 2|Bacteria C Belongs to the citrate synthase family gltA - 2.3.3.1,4.1.3.34 ko:K01647,ko:K15234 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R00351,R00354 RC00004,RC00067,RC00502 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt YYD3_k127_4624235_0 1379698.RBG1_1C00001G1656 0.0 1143.0 COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria 2|Bacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW YYD3_k127_4624235_4 1278073.MYSTI_03146 3.34e-15 81.0 COG1959@1|root,COG1959@2|Bacteria,1Q19C@1224|Proteobacteria,4375I@68525|delta/epsilon subdivisions,2WRDB@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Transcriptional regulator - - - - - - - - - - - - Rrf2 YYD3_k127_4624235_2 1379698.RBG1_1C00001G0222 3.88e-133 443.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria 2|Bacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N YYD3_k127_4624235_1 1499967.BAYZ01000139_gene157 1.226e-264 837.0 COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria 2|Bacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C YYD3_k127_4624235_3 1235799.C818_03736 3.294e-48 175.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,27J61@186928|unclassified Lachnospiraceae 186801|Clostridia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C YYD3_k127_4625534_2 1280949.HAD_06100 4.071e-20 105.0 29AWA@1|root,2ZXVE@2|Bacteria,1PAB6@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - YYD3_k127_4625534_0 1191523.MROS_1926 1.123e-168 539.0 COG0282@1|root,COG0282@2|Bacteria 2|Bacteria F acetate kinase activity ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0409 Acetate_kinase YYD3_k127_4625534_1 880073.Calab_0626 3.749e-105 349.0 COG1250@1|root,COG1250@2|Bacteria,2NQAW@2323|unclassified Bacteria 2|Bacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain hbd2 - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N YYD3_k127_4625534_3 1535422.ND16A_2150 2.622e-09 68.0 COG3485@1|root,COG4932@1|root,COG5276@1|root,COG3485@2|Bacteria,COG4932@2|Bacteria,COG5276@2|Bacteria,1QUEG@1224|Proteobacteria 1224|Proteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,CarboxypepD_reg,DUF11,FG-GAP YYD3_k127_4642438_12 1121918.ARWE01000001_gene1130 2.673e-12 78.0 28WYN@1|root,30ZZ9@2|Bacteria,1NPVB@1224|Proteobacteria,42XW6@68525|delta/epsilon subdivisions,2WTBQ@28221|Deltaproteobacteria,43VPR@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - Paired_CXXCH_1 YYD3_k127_4642438_1 1379698.RBG1_1C00001G1123 2.154e-204 649.0 COG1418@1|root,COG1418@2|Bacteria,2NNU5@2323|unclassified Bacteria 2|Bacteria S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 YYD3_k127_4642438_13 555088.DealDRAFT_2681 5.418e-09 61.0 COG3027@1|root,COG3027@2|Bacteria,1UFX5@1239|Firmicutes,25MWM@186801|Clostridia,42K8N@68298|Syntrophomonadaceae 186801|Clostridia D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA YYD3_k127_4642438_2 1379698.RBG1_1C00001G1120 6.008e-194 631.0 COG0072@1|root,COG0072@2|Bacteria,2NNXI@2323|unclassified Bacteria 2|Bacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind YYD3_k127_4642438_3 1089548.KI783301_gene455 7.236e-109 362.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,4HAVN@91061|Bacilli,3WEMW@539002|Bacillales incertae sedis 91061|Bacilli J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d YYD3_k127_4642438_7 1379698.RBG1_1C00001G1118 2.355e-35 137.0 COG0292@1|root,COG0292@2|Bacteria,2NPQQ@2323|unclassified Bacteria 2|Bacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 YYD3_k127_4642438_10 28258.KP05_13715 2.014e-15 77.0 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1XM10@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p YYD3_k127_4642438_5 1379698.RBG1_1C00001G1116 2.67e-58 209.0 COG0290@1|root,COG0290@2|Bacteria,2NPDH@2323|unclassified Bacteria 2|Bacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N YYD3_k127_4642438_0 1269813.ATUL01000025_gene2750 1.102e-234 742.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1WVYK@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD YYD3_k127_4642438_6 933262.AXAM01000030_gene823 5.734e-43 168.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WP0E@28221|Deltaproteobacteria,2MJVK@213118|Desulfobacterales 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD YYD3_k127_4642438_11 56780.SYN_02806 1.968e-14 78.0 COG1516@1|root,COG1516@2|Bacteria,1PSYY@1224|Proteobacteria,42V8K@68525|delta/epsilon subdivisions,2WRH1@28221|Deltaproteobacteria 28221|Deltaproteobacteria N PFAM flagellar protein FliS fliS - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS YYD3_k127_4642438_4 1125863.JAFN01000001_gene217 1.318e-88 321.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,42MHW@68525|delta/epsilon subdivisions,2WNU5@28221|Deltaproteobacteria 28221|Deltaproteobacteria N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N YYD3_k127_4642438_8 2325.TKV_c04860 2.879e-31 141.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia,42FKH@68295|Thermoanaerobacterales 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N YYD3_k127_4642438_9 448385.sce2881 5.518e-23 103.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTY9@29|Myxococcales 28221|Deltaproteobacteria T response regulator - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_4643724_1 1121430.JMLG01000001_gene2176 3.177e-95 321.0 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,2646G@186807|Peptococcaceae 186801|Clostridia T Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_4643724_6 443144.GM21_3168 9.748e-27 125.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43E1J@68525|delta/epsilon subdivisions,2WM21@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA YYD3_k127_4643724_7 1120983.KB894570_gene1233 8.324e-22 100.0 COG2050@1|root,COG2050@2|Bacteria,1PP3V@1224|Proteobacteria,2UVNH@28211|Alphaproteobacteria,1JPJM@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT YYD3_k127_4643724_8 1408444.JHYC01000008_gene1427 7.923e-06 49.0 2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_4643724_2 1379698.RBG1_1C00001G0779 6.804e-93 321.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB YYD3_k127_4643724_0 671143.DAMO_0821 5.462e-126 415.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B YYD3_k127_4643724_4 1379698.RBG1_1C00001G0781 3.396e-46 171.0 COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria 2|Bacteria C Rieske [2Fe-2S] domain petA - 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske,UCR_Fe-S_N YYD3_k127_4643724_3 99598.Cal7507_6086 3.366e-74 256.0 COG3548@1|root,COG3548@2|Bacteria,1GKP7@1117|Cyanobacteria,1HRK3@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function (DUF1211) - - - - - - - - - - - - DUF1211 YYD3_k127_4643724_5 1379698.RBG1_1C00001G0327 1.395e-35 151.0 COG1664@1|root,COG1664@2|Bacteria 2|Bacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin YYD3_k127_4681259_0 1379698.RBG1_1C00001G1021 1.3e-86 294.0 COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria 2|Bacteria I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 - R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf YYD3_k127_4681259_1 1379698.RBG1_1C00001G1022 7.731e-41 162.0 COG4589@1|root,COG4589@2|Bacteria,2NPVB@2323|unclassified Bacteria 2|Bacteria S Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 YYD3_k127_4681259_2 1379698.RBG1_1C00001G1024 3.464e-29 128.0 COG0382@1|root,COG0382@2|Bacteria,2NRJ9@2323|unclassified Bacteria 2|Bacteria H UbiA prenyltransferase family - - 2.5.1.133,2.5.1.39,2.5.1.62 ko:K03179,ko:K04040 ko00130,ko00860,ko01100,ko01110,map00130,map00860,map01100,map01110 M00117 R05000,R05615,R06284,R09067,R11514,R11517 RC00020,RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA YYD3_k127_4681259_3 1382358.JHVN01000009_gene3326 4.281e-26 113.0 COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4HH84@91061|Bacilli,21WTM@150247|Anoxybacillus 91061|Bacilli M NlpC/P60 family lytE - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SH3_3,SLH YYD3_k127_4681259_4 996306.SSUR61_0183 1.603e-20 93.0 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,4H9QH@91061|Bacilli,1WSG4@1307|Streptococcus suis 91061|Bacilli L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N YYD3_k127_4685234_9 1202532.FF52_08179 4.385e-37 147.0 COG3127@1|root,COG3127@2|Bacteria,4NN8S@976|Bacteroidetes,1I1UF@117743|Flavobacteriia,2NVBJ@237|Flavobacterium 976|Bacteroidetes Q membrane - - - - - - - - - - - - - YYD3_k127_4685234_11 1094466.KQS_07925 4.903e-30 123.0 COG0640@1|root,COG0640@2|Bacteria,4NSAV@976|Bacteroidetes,1I3VH@117743|Flavobacteriia,2NWRE@237|Flavobacterium 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - HTH_34 YYD3_k127_4685234_7 1227739.Hsw_0573 1.655e-42 162.0 2E3VP@1|root,32YSV@2|Bacteria,4NV28@976|Bacteroidetes,47S3V@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_4685234_14 1123057.P872_13040 4.878e-15 79.0 2EEZ4@1|root,30XX1@2|Bacteria,4PBHB@976|Bacteroidetes,47VW5@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_4685234_6 1329516.JPST01000012_gene28 4.961e-44 173.0 COG5017@1|root,COG5017@2|Bacteria,1V2RT@1239|Firmicutes,4I1HA@91061|Bacilli,27CY8@186824|Thermoactinomycetaceae 91061|Bacilli S D-glucuronyl C5-epimerase C-terminus - - - - - - - - - - - - C5-epim_C YYD3_k127_4685234_0 1379698.RBG1_1C00001G0598 3.635e-141 452.0 COG0568@1|root,COG0568@2|Bacteria,2NNY9@2323|unclassified Bacteria 2|Bacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 YYD3_k127_4685234_2 1379698.RBG1_1C00001G0597 5.416e-102 351.0 COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria 2|Bacteria O smart pdz dhr glgf degQ - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD3_k127_4685234_5 649747.HMPREF0083_01731 2.797e-53 196.0 COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,4HG91@91061|Bacilli,26TR3@186822|Paenibacillaceae 91061|Bacilli G Aldolase - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II YYD3_k127_4685234_8 1123376.AUIU01000013_gene1914 9.436e-39 159.0 COG0436@1|root,COG0436@2|Bacteria,3J0G2@40117|Nitrospirae 40117|Nitrospirae E Aminotransferase class I and II - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_4685234_13 1379698.RBG1_1C00001G0302 3.754e-26 117.0 COG1539@1|root,COG1539@2|Bacteria,2NQ1A@2323|unclassified Bacteria 2|Bacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB YYD3_k127_4685234_10 398767.Glov_0375 9.457e-31 127.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2WQ4P@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK YYD3_k127_4685234_4 880073.Calab_2860 6.689e-65 229.0 COG1428@1|root,COG1428@2|Bacteria,2NPEH@2323|unclassified Bacteria 2|Bacteria F Deoxynucleoside kinase dgk - 2.7.1.113 ko:K15518 ko00230,map00230 - R01967 RC00002,RC00017 ko00000,ko00001,ko01000 - - - HPPK,dNK YYD3_k127_4685234_3 1379698.RBG1_1C00001G0304 1.327e-91 308.0 COG0413@1|root,COG0413@2|Bacteria,2NP1G@2323|unclassified Bacteria 2|Bacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf YYD3_k127_4685234_1 439235.Dalk_2962 8.14e-126 422.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2MHTH@213118|Desulfobacterales 28221|Deltaproteobacteria KLT PFAM Protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding YYD3_k127_4692835_0 1379698.RBG1_1C00001G1355 3.122e-78 270.0 COG0811@1|root,COG0811@2|Bacteria,2NPUZ@2323|unclassified Bacteria 2|Bacteria U MotA/TolQ/ExbB proton channel family exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB YYD3_k127_4692835_2 1379698.RBG1_1C00001G1356 6.533e-37 145.0 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein exbD1 - - - - - - - - - - - ExbD YYD3_k127_4692835_3 1379698.RBG1_1C00001G1357 1.665e-32 134.0 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein exbD2 - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD YYD3_k127_4692835_1 1379698.RBG1_1C00001G1358 1.694e-46 177.0 COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C YYD3_k127_4692835_4 1379698.RBG1_1C00001G1358 1.349e-25 115.0 COG0810@1|root,COG0810@2|Bacteria,2NQ1D@2323|unclassified Bacteria 2|Bacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CarbopepD_reg_2,TonB_C YYD3_k127_4699551_3 518766.Rmar_2058 2.92e-47 181.0 COG2377@1|root,COG2377@2|Bacteria,4NFZU@976|Bacteroidetes,1FIM0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK YYD3_k127_4699551_2 941449.dsx2_1776 1.302e-56 210.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2WN0Z@28221|Deltaproteobacteria,2MGBG@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM glycoside hydrolase family 3 nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3,Glyco_hydro_3_C YYD3_k127_4699551_1 1379698.RBG1_1C00001G0325 3.474e-90 316.0 COG2199@1|root,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria 2|Bacteria T diguanylate cyclase - - - - - - - - - - - - GAF,GAF_2,GAF_3,GGDEF,MASE3,PAS_3,PAS_4,Response_reg YYD3_k127_4699551_0 671143.DAMO_0012 1.282e-209 665.0 COG1966@1|root,COG1966@2|Bacteria,2NNP2@2323|unclassified Bacteria 2|Bacteria T 5TM C-terminal transporter carbon starvation CstA cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM YYD3_k127_47081_3 888055.HMPREF9015_01781 2.749e-24 111.0 COG0742@1|root,COG0742@2|Bacteria,378KW@32066|Fusobacteria 32066|Fusobacteria L Psort location Cytoplasmic, score 8.96 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 YYD3_k127_47081_1 331113.SNE_A07610 1.761e-57 207.0 COG0164@1|root,COG0164@2|Bacteria,2JFYJ@204428|Chlamydiae 204428|Chlamydiae L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII YYD3_k127_47081_4 1280698.AUJS01000044_gene3380 1.091e-19 93.0 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,27VS6@189330|Dorea 186801|Clostridia L Uncharacterised protein family UPF0102 - - - ko:K07460 - - - - ko00000 - - - UPF0102 YYD3_k127_47081_2 1379698.RBG1_1C00001G0561 1.883e-40 159.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - ko:K02490 ko02020,ko02024,map02020,map02024 M00485 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c,HisKA_2,PAS_3,PAS_9,Response_reg,SpoIIE YYD3_k127_47081_0 42256.RradSPS_1129 4.393e-152 493.0 COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4CPEU@84995|Rubrobacteria 84995|Rubrobacteria G alpha beta alpha domain I - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV YYD3_k127_4735592_1 1304880.JAGB01000001_gene243 3.114e-115 387.0 COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia 186801|Clostridia J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 YYD3_k127_4735592_4 1379698.RBG1_1C00001G1224 2.891e-25 124.0 COG0745@1|root,COG0745@2|Bacteria 1379698.RBG1_1C00001G1224|- T phosphorelay signal transduction system - - - - - - - - - - - - - YYD3_k127_4735592_3 396588.Tgr7_0663 2.665e-28 130.0 COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,1S3XV@1236|Gammaproteobacteria,1WVYJ@135613|Chromatiales 135613|Chromatiales T signal transduction protein - - - - - - - - - - - - HDOD YYD3_k127_4735592_0 1536770.R50345_20750 2.524e-128 421.0 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4HA0H@91061|Bacilli,26QTH@186822|Paenibacillaceae 91061|Bacilli E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt YYD3_k127_4735592_2 1379698.RBG1_1C00001G1066 4.338e-99 338.0 COG0260@1|root,COG0260@2|Bacteria,2NNKH@2323|unclassified Bacteria 2|Bacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N YYD3_k127_4745709_7 315750.BPUM_0625 2.372e-14 74.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli,1ZCM9@1386|Bacillus 91061|Bacilli L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C YYD3_k127_4745709_6 1267533.KB906735_gene4737 1.924e-23 106.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 YYD3_k127_4745709_4 502025.Hoch_1468 5.316e-80 277.0 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,42VPN@68525|delta/epsilon subdivisions,2WRK6@28221|Deltaproteobacteria,2Z1WG@29|Myxococcales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA YYD3_k127_4745709_9 391587.KAOT1_10526 4.517e-11 72.0 COG2849@1|root,COG2849@2|Bacteria,4NMDX@976|Bacteroidetes,1I51X@117743|Flavobacteriia 976|Bacteroidetes M PFAM MORN repeat variant - - - - - - - - - - - - MORN_2,TPR_1,TPR_16,TPR_8 YYD3_k127_4745709_5 768704.Desmer_3702 7.177e-53 191.0 COG2318@1|root,COG2318@2|Bacteria,1V8MI@1239|Firmicutes 1239|Firmicutes S PFAM DinB family - - - - - - - - - - - - DinB YYD3_k127_4745709_2 316274.Haur_1687 3.655e-132 428.0 COG0667@1|root,COG0667@2|Bacteria,2G5YU@200795|Chloroflexi,376EH@32061|Chloroflexia 32061|Chloroflexia C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red YYD3_k127_4745709_10 68219.JNXI01000006_gene2065 4.265e-07 61.0 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - AAA_22,BTAD,NB-ARC,TPR_12,Trans_reg_C YYD3_k127_4745709_1 1379698.RBG1_1C00001G0635 2.738e-158 507.0 COG1089@1|root,COG1089@2|Bacteria,2NNM2@2323|unclassified Bacteria 2|Bacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd YYD3_k127_4745709_3 1379698.RBG1_1C00001G0636 2.339e-80 279.0 COG1089@1|root,COG1089@2|Bacteria,2NP6U@2323|unclassified Bacteria 2|Bacteria M Polysaccharide biosynthesis protein wcbK - 1.1.1.281,4.2.1.47 ko:K01711,ko:K15856 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888,R03397,R03399 RC00182,RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd YYD3_k127_4745709_0 1379698.RBG1_1C00001G0637 3.302e-186 592.0 COG0677@1|root,COG0677@2|Bacteria,2NNQ1@2323|unclassified Bacteria 2|Bacteria M UDP binding domain - - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N YYD3_k127_4745709_8 1379698.RBG1_1C00001G0231 7.934e-12 77.0 COG1413@1|root,COG1413@2|Bacteria,2NRMK@2323|unclassified Bacteria 2|Bacteria C HEAT repeats CP_0755 - - - - - - - - - - - HEAT_2,HEAT_PBS,Response_reg YYD3_k127_4808789_5 1379698.RBG1_1C00001G0394 1.776e-48 181.0 COG0771@1|root,COG0771@2|Bacteria,2NP27@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M YYD3_k127_4808789_2 1379698.RBG1_1C00001G0395 5.805e-88 302.0 COG0772@1|root,COG0772@2|Bacteria,2NP3P@2323|unclassified Bacteria 2|Bacteria D Belongs to the SEDS family ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 - FTSW_RODA_SPOVE YYD3_k127_4808789_4 1379698.RBG1_1C00001G0396 2.806e-80 290.0 COG0707@1|root,COG0707@2|Bacteria,2NP4Z@2323|unclassified Bacteria 2|Bacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 - R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - GT28 iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Glyco_tran_28_C,Glyco_transf_28 YYD3_k127_4808789_0 404380.Gbem_0492 8.544e-142 464.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M YYD3_k127_4808789_1 1379698.RBG1_1C00001G0399 2.598e-119 395.0 COG0849@1|root,COG0849@2|Bacteria,2NNU2@2323|unclassified Bacteria 2|Bacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA YYD3_k127_4808789_3 1379698.RBG1_1C00001G0400 1.533e-86 291.0 COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria 2|Bacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin YYD3_k127_4810629_12 398720.MED217_10482 4.47e-07 62.0 28JUF@1|root,2Z9JH@2|Bacteria,4NHS3@976|Bacteroidetes,1HYHH@117743|Flavobacteriia,2XJ92@283735|Leeuwenhoekiella 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_4810629_5 1379698.RBG1_1C00001G1420 8.201e-34 150.0 COG0457@1|root,COG0457@2|Bacteria 1379698.RBG1_1C00001G1420|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - YYD3_k127_4810629_2 42256.RradSPS_0187 3.793e-120 409.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GJW4@201174|Actinobacteria,4CQV5@84995|Rubrobacteria 84995|Rubrobacteria EU Peptidase S9, prolyl oligopeptidase - - - - - - - - - - - - PD40,Peptidase_S9 YYD3_k127_4810629_13 1379858.N508_00599 0.0003445 51.0 COG3087@1|root,COG3087@2|Bacteria,2GG1B@200930|Deferribacteres 200930|Deferribacteres D Sporulation related domain - - - - - - - - - - - - SPOR YYD3_k127_4810629_3 748280.NH8B_0056 2.034e-90 308.0 COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1MUBE@1224|Proteobacteria,2VPRG@28216|Betaproteobacteria,2KSUP@206351|Neisseriales 206351|Neisseriales E Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP YYD3_k127_4810629_10 1379698.RBG1_1C00001G1104 8.819e-13 77.0 2B0A3@1|root,31SM2@2|Bacteria,2NRWJ@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 YYD3_k127_4810629_7 1379698.RBG1_1C00001G1198 3.633e-23 99.0 COG1145@1|root,COG1145@2|Bacteria 2|Bacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein fdxN - - ko:K03522 - - - - ko00000,ko04147 - - - Fer4,HTH_3,HTH_31 YYD3_k127_4810629_6 765420.OSCT_1275 3.464e-33 148.0 COG1807@1|root,COG1807@2|Bacteria,2G8IK@200795|Chloroflexi,375EI@32061|Chloroflexia 32061|Chloroflexia M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - - YYD3_k127_4810629_0 1379698.RBG1_1C00001G1309 3.929e-147 481.0 COG0297@1|root,COG0297@2|Bacteria,2NP1F@2323|unclassified Bacteria 2|Bacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 YYD3_k127_4810629_1 1162668.LFE_2206 1.304e-128 419.0 COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae 40117|Nitrospirae H Galactose-1-phosphate uridyl transferase, N-terminal domain galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf YYD3_k127_4810629_4 1379698.RBG1_1C00001G1107 1.721e-58 216.0 COG1207@1|root,COG1207@2|Bacteria,2NQ8F@2323|unclassified Bacteria 2|Bacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_4 YYD3_k127_4810629_11 404589.Anae109_2146 8.565e-12 72.0 COG1403@1|root,COG1403@2|Bacteria 2|Bacteria V endonuclease activity - - - - - - - - - - - - DUF222 YYD3_k127_4812764_3 929556.Solca_2518 4.307e-22 98.0 2CMS6@1|root,32SFE@2|Bacteria,4NWI0@976|Bacteroidetes,1IYER@117747|Sphingobacteriia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 YYD3_k127_4812764_0 153721.MYP_33 1.179e-73 258.0 COG0077@1|root,COG0077@2|Bacteria,4NEEK@976|Bacteroidetes,47NM0@768503|Cytophagia 976|Bacteroidetes E PFAM Prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT YYD3_k127_4812764_1 945713.IALB_3117 1.629e-40 154.0 2DTJ6@1|root,33KM6@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_4812764_2 1144313.PMI10_00587 1.549e-31 127.0 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes,1I2T3@117743|Flavobacteriia,2NVZM@237|Flavobacterium 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 YYD3_k127_4823786_2 316067.Geob_1620 7.389e-20 97.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - ko:K16191,ko:K20276 ko02024,map02024 - - - ko00000,ko00001,ko02000 1.B.6.1.3 - - Big_3_2,Calx-beta,OmpA YYD3_k127_4823786_1 945713.IALB_0760 5.542e-27 127.0 COG4219@1|root,COG4219@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 YYD3_k127_4823786_0 1379698.RBG1_1C00001G1368 1.392e-38 154.0 COG4219@1|root,COG4219@2|Bacteria,2NS3V@2323|unclassified Bacteria 2|Bacteria KT Peptidase M56 - - - - - - - - - - - - Amidase_6,DUF4309,DUF5301 YYD3_k127_48382_1 1313265.JNIE01000002_gene712 5.524e-80 282.0 COG0277@1|root,COG0277@2|Bacteria,2G3NK@200783|Aquificae 200783|Aquificae C FAD linked oxidase domain protein - - 1.1.3.15,1.1.5.12 ko:K00104,ko:K03777 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00475,R00704,R11591 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 YYD3_k127_48382_4 880073.Calab_0928 5.542e-24 105.0 COG2331@1|root,COG2331@2|Bacteria,2NQ36@2323|unclassified Bacteria 2|Bacteria S Putative regulatory protein fmdB - - - - - - - - - - - Zn-ribbon_8 YYD3_k127_48382_0 945713.IALB_1601 5.41e-200 638.0 COG0659@1|root,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - iSbBS512_1146.SbBS512_E1370 STAS,Sulfate_transp YYD3_k127_48382_3 1121406.JAEX01000005_gene2987 7.509e-34 135.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2WRJJ@28221|Deltaproteobacteria,2MCMH@213115|Desulfovibrionales 28221|Deltaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB YYD3_k127_48382_2 580340.Tlie_1484 7.997e-46 168.0 COG1993@1|root,COG1993@2|Bacteria,3TCBR@508458|Synergistetes 508458|Synergistetes S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 YYD3_k127_4846470_0 690850.Desaf_0617 3.814e-123 414.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C YYD3_k127_4900531_2 945713.IALB_2083 4.432e-32 141.0 COG0728@1|root,COG0728@2|Bacteria 2|Bacteria M peptidoglycan biosynthetic process - - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN YYD3_k127_4900531_0 1379698.RBG1_1C00001G1539 1.318e-136 447.0 COG0399@1|root,COG0399@2|Bacteria,2NNS2@2323|unclassified Bacteria 2|Bacteria E Belongs to the DegT DnrJ EryC1 family degT - - - - - - - - - - - DegT_DnrJ_EryC1 YYD3_k127_4900531_1 857293.CAAU_2200 1.1e-102 339.0 COG1044@1|root,COG1044@2|Bacteria,1UHYP@1239|Firmicutes,25E78@186801|Clostridia,36F2P@31979|Clostridiaceae 186801|Clostridia M Hexapeptide repeat of succinyl-transferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2 YYD3_k127_4900531_3 382464.ABSI01000012_gene1958 5.419e-05 51.0 COG3765@1|root,COG3765@2|Bacteria 2|Bacteria M lipopolysaccharide biosynthetic process wzz - - - - - - - - - - - GNVR,Wzz YYD3_k127_490558_0 1379698.RBG1_1C00001G1750 1.736e-86 300.0 COG0457@1|root,COG0457@2|Bacteria,2NRMR@2323|unclassified Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - DUF4388 YYD3_k127_490558_4 1379698.RBG1_1C00001G1748 9.819e-49 185.0 COG0457@1|root,COG0457@2|Bacteria,2NS1B@2323|unclassified Bacteria 2|Bacteria M Tetratricopeptide repeat - - - - - - - - - - - - - YYD3_k127_490558_5 1379698.RBG1_1C00001G1746 2.364e-37 144.0 COG2018@1|root,COG2018@2|Bacteria,2NRUR@2323|unclassified Bacteria 2|Bacteria S Roadblock/LC7 domain - - - ko:K07131 - - - - ko00000 - - - Robl_LC7 YYD3_k127_490558_1 1379698.RBG1_1C00001G1745 8.173e-85 292.0 COG1100@1|root,COG1100@2|Bacteria,2NPDD@2323|unclassified Bacteria 2|Bacteria K - Catabolite gene activator and regulatory subunit of cAMP-dependent protein mglA GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - ko:K06883 - - - - ko00000 - - - Arf,DUF697,MMR_HSR1 YYD3_k127_490558_2 1379698.RBG1_1C00001G1744 5.292e-64 222.0 COG2018@1|root,COG2018@2|Bacteria,2NQXH@2323|unclassified Bacteria 2|Bacteria S Roadblock/LC7 domain mglB - - - - - - - - - - - Robl_LC7 YYD3_k127_490558_3 1379698.RBG1_1C00001G1743 1.774e-61 215.0 COG2804@1|root,COG2804@2|Bacteria,2NNNI@2323|unclassified Bacteria 2|Bacteria NU Type II secretion system (T2SS), protein E, N-terminal domain pilB - - ko:K02454,ko:K02504,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N YYD3_k127_4932314_1 1379698.RBG1_1C00001G1884 1.991e-46 173.0 COG0558@1|root,COG0558@2|Bacteria,2NPJ9@2323|unclassified Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iSB619.SA_RS06365 CDP-OH_P_transf YYD3_k127_4932314_3 1519464.HY22_12230 7.974e-32 129.0 COG1267@1|root,COG1267@2|Bacteria,1FE6P@1090|Chlorobi 1090|Chlorobi I PFAM phosphatidylglycerophosphatase A - - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA YYD3_k127_4932314_0 1379698.RBG1_1C00001G1886 8.239e-115 384.0 COG1058@1|root,COG1058@2|Bacteria,2NP0G@2323|unclassified Bacteria 2|Bacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth YYD3_k127_4932314_2 429009.Adeg_1729 3.027e-32 133.0 COG1514@1|root,COG1514@2|Bacteria,1VEU2@1239|Firmicutes,24MTR@186801|Clostridia,42H6P@68295|Thermoanaerobacterales 186801|Clostridia J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase YYD3_k127_4938185_1 1379698.RBG1_1C00001G1315 3.696e-19 92.0 COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 arnC - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 YYD3_k127_4938185_0 1183438.GKIL_3722 3.703e-105 353.0 COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N YYD3_k127_4939222_4 1183438.GKIL_3263 1.378e-07 64.0 COG1470@1|root,COG3391@1|root,COG1470@2|Bacteria,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria 1117|Cyanobacteria DZ PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,VCBS YYD3_k127_4939222_2 1379698.RBG1_1C00001G0518 2.45e-135 460.0 COG0515@1|root,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 YYD3_k127_4939222_0 1340493.JNIF01000003_gene2186 3.572e-221 730.0 COG1026@1|root,COG1026@2|Bacteria 2|Bacteria S Peptidase M16C associated - - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C,SLH YYD3_k127_4939222_3 269797.Mbar_A0726 2.911e-34 154.0 arCOG02527@1|root,arCOG02527@2157|Archaea,2XYVG@28890|Euryarchaeota 28890|Euryarchaeota S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PKD YYD3_k127_4939222_1 269797.Mbar_A3461 3.028e-204 678.0 COG3291@1|root,COG3391@1|root,arCOG02516@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02508@2157|Archaea,arCOG02516@2157|Archaea,arCOG02550@2157|Archaea,arCOG02562@2157|Archaea,arCOG03991@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia 224756|Methanomicrobia O PFAM PKD domain containing protein - - - - - - - - - - - - PKD YYD3_k127_49412_1 1317122.ATO12_12975 1.658e-38 155.0 COG1520@1|root,COG2133@1|root,COG2356@1|root,COG3227@1|root,COG1520@2|Bacteria,COG2133@2|Bacteria,COG2356@2|Bacteria,COG3227@2|Bacteria,4NF0B@976|Bacteroidetes,1HX9D@117743|Flavobacteriia,2YHIU@290174|Aquimarina 976|Bacteroidetes EG Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_6,GSDH YYD3_k127_49412_0 635013.TherJR_0008 1.796e-271 852.0 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,260WQ@186807|Peptococcaceae 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim YYD3_k127_49412_3 446465.Bfae_00040 3.293e-07 58.0 COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4FBS4@85020|Dermabacteraceae 201174|Actinobacteria S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 YYD3_k127_49412_2 1301098.PKB_0660 3.884e-09 57.0 COG2132@1|root,COG2132@2|Bacteria,1QZ1I@1224|Proteobacteria,1S18S@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22350 - - - - ko00000,ko01000 - - - Cu-oxidase_2 YYD3_k127_4954059_0 671143.DAMO_2917 5.362e-191 617.0 COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria 2|Bacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - Aldo_ket_red,GlcNAc_2-epim,Thioredox_DsbH YYD3_k127_4954059_3 517418.Ctha_1221 9.834e-40 165.0 2ECQK@1|root,336N8@2|Bacteria,1FEWY@1090|Chlorobi 1090|Chlorobi S Capsule assembly protein Wzi - - - - - - - - - - - - Caps_assemb_Wzi YYD3_k127_4954059_2 1232410.KI421421_gene3366 6.991e-89 312.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,43UQ6@69541|Desulfuromonadales 28221|Deltaproteobacteria M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 YYD3_k127_4954059_5 273068.TTE2137 1.01e-16 92.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,42FUW@68295|Thermoanaerobacterales 186801|Clostridia E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_4954059_1 316067.Geob_3002 8.635e-109 385.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42M62@68525|delta/epsilon subdivisions,2WJ83@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Polysaccharide export protein - - - - - - - - - - - - Poly_export,SLBB YYD3_k127_4954059_4 1379698.RBG1_1C00001G0660 4.161e-38 155.0 COG2067@1|root,COG2067@2|Bacteria,2NPN1@2323|unclassified Bacteria 2|Bacteria I Membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X YYD3_k127_5001048_6 1237149.C900_00291 4.911e-43 161.0 2CHCP@1|root,32S5R@2|Bacteria,4NS9G@976|Bacteroidetes,47RF4@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 YYD3_k127_5001048_3 1379698.RBG1_1C00001G1232 9.753e-69 237.0 COG1403@1|root,COG1403@2|Bacteria,2NPJD@2323|unclassified Bacteria 2|Bacteria L HNH endonuclease mcrA - - - - - - - - - - - HNH,HNH_4,HNH_5 YYD3_k127_5001048_5 251229.Chro_2803 1.374e-47 175.0 COG1846@1|root,COG1846@2|Bacteria,1G6XI@1117|Cyanobacteria 1117|Cyanobacteria K MarR family transcriptional - - - ko:K15973 - - - - ko00000,ko03000 - - - MarR YYD3_k127_5001048_1 1540257.JQMW01000009_gene3300 5.339e-75 263.0 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,36EAK@31979|Clostridiaceae 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 YYD3_k127_5001048_4 1397527.Q670_11265 1.903e-49 186.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XIZA@135619|Oceanospirillales 135619|Oceanospirillales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD YYD3_k127_5001048_2 1304880.JAGB01000002_gene2401 4.548e-69 243.0 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia 186801|Clostridia L hydrolase, TatD family tatD - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase YYD3_k127_5001048_0 994573.T472_0209805 1.624e-155 512.0 COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,36E2T@31979|Clostridiaceae 186801|Clostridia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind YYD3_k127_5005422_3 1379698.RBG1_1C00001G1764 3.804e-37 146.0 COG2120@1|root,COG2120@2|Bacteria,2NPAV@2323|unclassified Bacteria 2|Bacteria S GlcNAc-PI de-N-acetylase bshB1 - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L YYD3_k127_5005422_4 1519464.HY22_00560 3.848e-22 113.0 COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR,Reprolysin_5 YYD3_k127_5005422_6 1223523.H340_14456 2.843e-15 82.0 COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria 201174|Actinobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 YYD3_k127_5005422_1 1379698.RBG1_1C00001G0402 1.976e-193 626.0 COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria 2|Bacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge YYD3_k127_5005422_5 1379698.RBG1_1C00001G0404 1.741e-19 92.0 2EAFJ@1|root,334IY@2|Bacteria,2NRZR@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 YYD3_k127_5005422_2 1379698.RBG1_1C00001G0434 2.739e-68 243.0 COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria 2|Bacteria M Cell wall formation murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C YYD3_k127_5005422_0 1379698.RBG1_1C00001G0435 2.048e-220 734.0 COG1747@1|root,COG1747@2|Bacteria,2NP33@2323|unclassified Bacteria 2|Bacteria M methyltransferase greA - - - - - - - - - - - GreA_GreB,GreA_GreB_N,SprA_N YYD3_k127_5006244_8 243231.GSU0881 7.92e-11 72.0 COG4251@1|root,COG5000@1|root,COG4251@2|Bacteria,COG5000@2|Bacteria,1QXNE@1224|Proteobacteria 1224|Proteobacteria T Signal transduction Histidine - - - - - - - - - - - - HATPase_c,HisKA YYD3_k127_5006244_7 580327.Tthe_2127 1.071e-30 134.0 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,42G7T@68295|Thermoanaerobacterales 186801|Clostridia S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind YYD3_k127_5006244_2 945713.IALB_2907 6.898e-119 416.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD3_k127_5006244_5 880073.Calab_3298 1.545e-61 241.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family ebh - - - - - - - - - - - DUF1611,Inhibitor_I9,Peptidase_S8,SLH YYD3_k127_5006244_4 880073.Calab_3299 2.699e-68 244.0 COG2067@1|root,COG2067@2|Bacteria,2NRA4@2323|unclassified Bacteria 2|Bacteria I PFAM Uncharacterised protein family (UPF0164) - - - - - - - - - - - - UPF0164 YYD3_k127_5006244_0 471852.Tcur_2047 1.388e-144 473.0 COG1249@1|root,COG1249@2|Bacteria,2GPG1@201174|Actinobacteria,4EI74@85012|Streptosporangiales 201174|Actinobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain sthA - 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim YYD3_k127_5006244_3 446469.Sked_04720 9.089e-73 250.0 COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria 201174|Actinobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 YYD3_k127_5006244_6 1379698.RBG1_1C00001G1658 1.048e-32 130.0 COG0718@1|root,COG0718@2|Bacteria,2NPUK@2323|unclassified Bacteria 2|Bacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd YYD3_k127_5006244_1 1379698.RBG1_1C00001G1659 2.126e-124 418.0 COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria 2|Bacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 YYD3_k127_5014109_0 452637.Oter_1454 0.0 1261.0 COG0841@1|root,COG0841@2|Bacteria,46SER@74201|Verrucomicrobia 74201|Verrucomicrobia V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran YYD3_k127_5014109_3 1121918.ARWE01000001_gene2983 2.274e-46 184.0 COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2WKAK@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 YYD3_k127_5014109_7 1382306.JNIM01000001_gene3599 4.9e-20 99.0 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - - - - - - - - - - HTH_20,HTH_5 YYD3_k127_5014109_1 1047013.AQSP01000130_gene1864 6.15e-202 638.0 COG0591@1|root,COG0591@2|Bacteria,2NPAX@2323|unclassified Bacteria 2|Bacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF YYD3_k127_5014109_2 1047013.AQSP01000130_gene1863 9.964e-97 331.0 28KQH@1|root,2ZA8A@2|Bacteria 2|Bacteria S Alginate export - - - - - - - - - - - - Alginate_exp YYD3_k127_5014109_5 28072.Nos7524_0700 1.477e-43 164.0 COG4405@1|root,COG4405@2|Bacteria,1GE0T@1117|Cyanobacteria 1117|Cyanobacteria S ASCH - - - - - - - - - - - - ASCH YYD3_k127_5014109_4 1047013.AQSP01000093_gene14 4.866e-44 162.0 COG2920@1|root,COG2920@2|Bacteria,2NQ6I@2323|unclassified Bacteria 2|Bacteria P DsrC like protein dsrC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC YYD3_k127_5014109_6 1047013.AQSP01000093_gene13 2.969e-32 133.0 COG2181@1|root,COG2181@2|Bacteria 2|Bacteria C nitrate reductase activity - - - - - - - - - - - - SLAC1 YYD3_k127_5014109_8 1047013.AQSP01000077_gene2274 2.269e-11 66.0 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process - - - - - - - - - - - - CCG,Fer4_17,Fer4_8,Fer4_9 YYD3_k127_5034234_0 1499967.BAYZ01000028_gene1230 7.148e-69 243.0 COG0726@1|root,COG0726@2|Bacteria,2NPFG@2323|unclassified Bacteria 2|Bacteria G Domain of unknown function (DUF3473) - - - - - - - - - - - - DUF3473,Polysacc_deac_1 YYD3_k127_5034234_1 1487921.DP68_03665 3.966e-40 160.0 COG0489@1|root,COG0489@2|Bacteria,1TS4R@1239|Firmicutes,24B0Z@186801|Clostridia,36DN2@31979|Clostridiaceae 186801|Clostridia D Capsular exopolysaccharide family - - - - - - - - - - - - AAA_31,ParA YYD3_k127_5034234_3 46234.ANA_C12709 8.725e-05 54.0 COG0457@1|root,COG0457@2|Bacteria,1G649@1117|Cyanobacteria,1HM2D@1161|Nostocales 1117|Cyanobacteria S PFAM Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_2,TPR_8 YYD3_k127_5034234_2 247490.KSU1_C0424 1.75e-19 100.0 COG1596@1|root,COG1596@2|Bacteria,2J1I5@203682|Planctomycetes 203682|Planctomycetes M SLBB domain - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB YYD3_k127_5040019_6 395495.Lcho_0286 3.681e-21 98.0 COG3181@1|root,COG3181@2|Bacteria,1N00G@1224|Proteobacteria,2VN46@28216|Betaproteobacteria,1KJ3Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC YYD3_k127_5040019_2 632292.Calhy_2037 2.555e-93 317.0 COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,42EVQ@68295|Thermoanaerobacterales 186801|Clostridia G TIGRFAM bifunctional phosphoglucose phosphomannose isomerase - - 5.3.1.8,5.3.1.9 ko:K15916 ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R01819,R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 - - - SIS,bact-PGI_C YYD3_k127_5040019_0 273068.TTE2334 2.071e-115 392.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,42FHW@68295|Thermoanaerobacterales 186801|Clostridia G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9,2.7.9.2 ko:K01007,ko:K08483 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C YYD3_k127_5040019_1 1379698.RBG1_1C00001G1819 5.007e-101 362.0 28KE7@1|root,2ZA0G@2|Bacteria,2NPZB@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_5040019_5 297246.lpp0540 1.812e-23 102.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SX88@1236|Gammaproteobacteria,1JEY3@118969|Legionellales 118969|Legionellales G PTS HPr component phosphorylation site ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr YYD3_k127_5040019_3 1379698.RBG1_1C00001G1623 8.154e-82 285.0 COG0758@1|root,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria 2|Bacteria LU DNA recombination-mediator protein A dprA - 5.99.1.2 ko:K03168,ko:K04096 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_processg_A YYD3_k127_5040019_4 1123278.KB893548_gene4697 1.266e-56 203.0 COG0536@1|root,COG0536@2|Bacteria,4NEK4@976|Bacteroidetes,47JCS@768503|Cytophagia 976|Bacteroidetes S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 YYD3_k127_5073906_8 756272.Plabr_0350 1.003e-11 68.0 COG0215@1|root,COG0215@2|Bacteria,2IX9C@203682|Planctomycetes 203682|Planctomycetes J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g YYD3_k127_5073906_0 1382358.JHVN01000020_gene1410 4.439e-113 375.0 COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,4H9SM@91061|Bacilli,21V1J@150247|Anoxybacillus 91061|Bacilli G M42 glutamyl aminopeptidase ysdC - - - - - - - - - - - Peptidase_M42 YYD3_k127_5073906_5 1379698.RBG1_1C00001G0843 1.013e-46 179.0 COG1011@1|root,COG1011@2|Bacteria,2NQ1K@2323|unclassified Bacteria 2|Bacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.1.3.5 ko:K07025,ko:K08723 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 YYD3_k127_5073906_2 945713.IALB_0732 3.523e-80 283.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N YYD3_k127_5073906_7 1121930.AQXG01000015_gene1880 1.624e-13 78.0 COG0586@1|root,COG0586@2|Bacteria 2|Bacteria S FtsZ-dependent cytokinesis yngC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - SNARE_assoc YYD3_k127_5073906_3 1158150.KB906242_gene166 5.347e-56 199.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1WY23@135613|Chromatiales 135613|Chromatiales I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB YYD3_k127_5073906_4 485916.Dtox_0261 9.647e-51 188.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia 186801|Clostridia I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20335 IspD YYD3_k127_5073906_1 868864.Dester_1458 1.815e-97 331.0 COG0809@1|root,COG0809@2|Bacteria,2G3KG@200783|Aquificae 200783|Aquificae J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth YYD3_k127_5073906_6 177437.HRM2_30510 5.337e-40 151.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,2MHYU@213118|Desulfobacterales 28221|Deltaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N YYD3_k127_5073985_15 1379698.RBG1_1C00001G0159 3.635e-16 79.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_5073985_3 1287276.X752_11730 8.35e-88 297.0 COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria 28211|Alphaproteobacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU,PEMT YYD3_k127_5073985_5 690850.Desaf_3498 8.831e-72 266.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - Beta_helix,Big_2,CarboxypepD_reg,He_PIG,LysM,PSII_BNR,SLH,TIG,fn3 YYD3_k127_5073985_2 1444711.CCJF01000005_gene546 3.065e-103 375.0 COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_5,Calx-beta,SBBP YYD3_k127_5073985_19 7955.ENSDARP00000124920 1.168e-05 59.0 2CMRF@1|root,2QRK8@2759|Eukaryota,38BZ6@33154|Opisthokonta,3BC6D@33208|Metazoa,3CRA6@33213|Bilateria,4834K@7711|Chordata,48Z6Z@7742|Vertebrata,49RWU@7898|Actinopterygii 33208|Metazoa W Thrombospondin 2a THBS2 GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0007275,GO:0008150,GO:0008201,GO:0009790,GO:0009888,GO:0009987,GO:0012505,GO:0016525,GO:0016528,GO:0016529,GO:0022603,GO:0030141,GO:0030154,GO:0030855,GO:0031012,GO:0031091,GO:0031410,GO:0031982,GO:0032501,GO:0032502,GO:0035989,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044087,GO:0044089,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045765,GO:0048518,GO:0048519,GO:0048522,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050803,GO:0050807,GO:0051093,GO:0051094,GO:0051128,GO:0051130,GO:0051239,GO:0051240,GO:0051241,GO:0051960,GO:0051962,GO:0051963,GO:0051965,GO:0060231,GO:0060429,GO:0061053,GO:0061448,GO:0062023,GO:0065007,GO:0065008,GO:0097367,GO:0097708,GO:0099503,GO:1901342,GO:1901343,GO:1901681,GO:2000026,GO:2000181 - ko:K04659,ko:K16857 ko04015,ko04115,ko04145,ko04151,ko04350,ko04510,ko04512,ko05144,ko05165,ko05205,ko05206,ko05219,map04015,map04115,map04145,map04151,map04350,map04510,map04512,map05144,map05165,map05205,map05206,map05219 - - - ko00000,ko00001,ko00536,ko04131,ko04147,ko04516 - - - EGF_3,EGF_CA,TSP_1,TSP_3,TSP_C,VWC YYD3_k127_5073985_8 1379698.RBG1_1C00001G0301 3.692e-40 173.0 COG2706@1|root,COG2706@2|Bacteria,2NR81@2323|unclassified Bacteria 2|Bacteria G Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - - - - - - - - - - Big_5,VCBS YYD3_k127_5073985_0 1379698.RBG1_1C00001G0414 0.0 1026.0 COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria 2|Bacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iLJ478.TM1817 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 YYD3_k127_5073985_4 648996.Theam_1519 1.943e-72 253.0 COG1694@1|root,COG3956@2|Bacteria,2G3T8@200783|Aquificae 200783|Aquificae S TIGRFAM MazG family protein mazG - - ko:K02499 - - - - ko00000,ko03036 - - - MazG YYD3_k127_5073985_18 459349.CLOAM1774 1.518e-06 60.0 2F9BU@1|root,341NU@2|Bacteria,2NR9C@2323|unclassified Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_5073985_16 642492.Clole_4234 9.9e-08 62.0 2F9S3@1|root,34222@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_5073985_1 880073.Calab_2857 3.058e-172 565.0 COG0265@1|root,COG0265@2|Bacteria 2|Bacteria O serine-type endopeptidase activity - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - DUF2808,Peptidase_S46 YYD3_k127_5073985_13 926560.KE387023_gene2348 4.781e-27 119.0 COG0454@1|root,COG0456@2|Bacteria,1WMUE@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 YYD3_k127_5073985_6 210007.SMU_1230c 1.307e-45 169.0 COG4333@1|root,COG4333@2|Bacteria,1VEFV@1239|Firmicutes,4HPB9@91061|Bacilli 91061|Bacilli S Protein conserved in bacteria - - - - - - - - - - - - DUF1643 YYD3_k127_5073985_9 1313265.JNIE01000006_gene128 4.349e-40 158.0 COG0193@1|root,COG0193@2|Bacteria,2G42F@200783|Aquificae 200783|Aquificae J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro YYD3_k127_5073985_14 1379698.RBG1_1C00001G0133 1.247e-18 93.0 COG0360@1|root,COG0360@2|Bacteria,2NQ1Q@2323|unclassified Bacteria 2|Bacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 YYD3_k127_5073985_11 1379698.RBG1_1C00001G0132 2.589e-31 129.0 COG0629@1|root,COG0629@2|Bacteria,2NPP5@2323|unclassified Bacteria 2|Bacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB YYD3_k127_5073985_12 1379698.RBG1_1C00001G0131 1.916e-27 113.0 COG0238@1|root,COG0238@2|Bacteria,2NPTU@2323|unclassified Bacteria 2|Bacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 YYD3_k127_5073985_7 1379698.RBG1_1C00001G0130 2.233e-40 154.0 COG0359@1|root,COG0359@2|Bacteria,2NPX4@2323|unclassified Bacteria 2|Bacteria J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N YYD3_k127_5073985_10 1379698.RBG1_1C00001G0129 9.597e-39 147.0 COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria 2|Bacteria S Bifunctional nuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K03617,ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR YYD3_k127_5092587_0 690850.Desaf_0617 1.551e-139 455.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C YYD3_k127_5092587_1 1379698.RBG1_1C00001G0340 8.341e-130 436.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,2NNRF@2323|unclassified Bacteria 2|Bacteria MU WD40-like Beta Propeller Repeat - - - ko:K03641,ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33,2.C.1.2 - - Bac_surface_Ag,PD40,POTRA,Peptidase_MA_2 YYD3_k127_51134_2 1410613.JNKF01000001_gene2410 9.762e-78 265.0 COG0745@1|root,COG0745@2|Bacteria,4NF1I@976|Bacteroidetes,2FNZV@200643|Bacteroidia 976|Bacteroidetes K transcriptional regulatory protein rprY - - - - - - - - - - - Response_reg,Trans_reg_C YYD3_k127_51134_7 251221.35210693 2.445e-25 114.0 COG3324@1|root,COG3324@2|Bacteria,1G8CB@1117|Cyanobacteria 1117|Cyanobacteria S Glyoxalase-like domain - - - ko:K06996 - - - - ko00000 - - - Glyoxalase YYD3_k127_51134_4 391625.PPSIR1_06381 2.78e-58 216.0 COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria 1224|Proteobacteria KLT serine threonine protein kinase pknB - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase YYD3_k127_51134_5 1254432.SCE1572_21210 1.322e-57 209.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD3_k127_51134_1 1379698.RBG1_1C00001G1724 2.221e-115 381.0 COG0845@1|root,COG0845@2|Bacteria,2NR7K@2323|unclassified Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mdtA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 YYD3_k127_51134_0 1379698.RBG1_1C00001G1725 0.0 1499.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran YYD3_k127_51134_3 945713.IALB_0515 1.283e-64 226.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - AhpC-TSA YYD3_k127_5124161_6 653386.HMPREF0975_01905 1.333e-09 64.0 COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria,4D5JE@85005|Actinomycetales 201174|Actinobacteria OU Nodulation efficiency protein D nfeD - - - - - - - - - - - NfeD YYD3_k127_5124161_2 273068.TTE2746 1.628e-85 304.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,24A6D@186801|Clostridia,42J4J@68295|Thermoanaerobacterales 186801|Clostridia C Best Blastp hit gi 7462068 pir H72266 astB chuR-related protein - Thermotoga maritima (strain MSB8) gi 4981883 gb AAD36396.1 AE001787_1 (AE001787) astB chuR-related protein Thermotoga maritima , score - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM YYD3_k127_5124161_4 203119.Cthe_0533 2.499e-80 282.0 COG0457@1|root,COG0535@1|root,COG0457@2|Bacteria,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,3WHA6@541000|Ruminococcaceae 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM YYD3_k127_5124161_0 1304880.JAGB01000002_gene1563 1.292e-114 391.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran YYD3_k127_5124161_7 1233950.IW22_18060 4.551e-06 58.0 COG0457@1|root,COG0457@2|Bacteria,4NPJG@976|Bacteroidetes,1IJ3M@117743|Flavobacteriia,3ZP1G@59732|Chryseobacterium 976|Bacteroidetes S Aerotolerance regulator BatC batC - - - - - - - - - - - TPR_1,TPR_16,TPR_2 YYD3_k127_5124161_3 1379698.RBG1_1C00001G0285 3.216e-82 280.0 COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria 2|Bacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N YYD3_k127_5124161_1 1047013.AQSP01000142_gene195 8.627e-98 332.0 COG0787@1|root,COG0787@2|Bacteria,2NP3R@2323|unclassified Bacteria 2|Bacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N YYD3_k127_5124161_5 1107311.Q767_15005 1.674e-33 136.0 COG3485@1|root,COG3485@2|Bacteria,4NEZ1@976|Bacteroidetes,1I01Q@117743|Flavobacteriia,2NVGG@237|Flavobacterium 976|Bacteroidetes Q Dioxygenase - - 1.13.11.3 ko:K00449 ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220 - R01631,R03549 RC00388,RC00953 br01602,ko00000,ko00001,ko01000 - - - Dioxygenase_C YYD3_k127_5128487_5 1121921.KB898708_gene1594 2.43e-25 115.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,2PN6R@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Bacterial trigger factor protein (TF) C-terminus tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N YYD3_k127_5128487_2 1268622.AVS7_03228 1.146e-85 291.0 COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,2VJHB@28216|Betaproteobacteria,4AHHU@80864|Comamonadaceae 28216|Betaproteobacteria P Cation efflux family - - - - - - - - - - - - Cation_efflux,HMA YYD3_k127_5128487_4 1499967.BAYZ01000050_gene2839 3.511e-36 145.0 COG0640@1|root,COG0640@2|Bacteria,2NQ13@2323|unclassified Bacteria 2|Bacteria K helix_turn_helix, Arsenical Resistance Operon Repressor arsR - 3.6.4.12 ko:K03655,ko:K03892 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - HTH_20,HTH_5 YYD3_k127_5128487_0 525897.Dbac_1904 3.409e-197 622.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2M9VF@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 YYD3_k127_5128487_7 1121918.ARWE01000001_gene2104 3.926e-23 101.0 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,42V0C@68525|delta/epsilon subdivisions,2WRJR@28221|Deltaproteobacteria,43VV1@69541|Desulfuromonadales 28221|Deltaproteobacteria CO Thioredoxin domain - - - - - - - - - - - - Thioredoxin_3 YYD3_k127_5128487_6 1304885.AUEY01000001_gene3204 8.546e-25 109.0 2DPAK@1|root,33193@2|Bacteria,1NDU6@1224|Proteobacteria,432ZD@68525|delta/epsilon subdivisions,2WYIN@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_5128487_3 595460.RRSWK_03132 3.727e-59 212.0 COG0785@1|root,COG0785@2|Bacteria,2J2ZI@203682|Planctomycetes 203682|Planctomycetes O Cytochrome C biogenesis protein transmembrane region - - - - - - - - - - - - DsbD_2 YYD3_k127_5128487_1 489825.LYNGBM3L_30250 1.919e-89 301.0 COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,1H9U9@1150|Oscillatoriales 1117|Cyanobacteria C NADPH quinone reductase - - - - - - - - - - - - ADH_N,ADH_zinc_N_2 YYD3_k127_5139976_3 1396141.BATP01000003_gene4868 1.469e-40 156.0 COG1131@1|root,COG1131@2|Bacteria,46SHV@74201|Verrucomicrobia,2IVHQ@203494|Verrucomicrobiae 203494|Verrucomicrobiae V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran YYD3_k127_5139976_5 309807.SRU_1196 3.345e-13 79.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4 YYD3_k127_5139976_6 1232410.KI421413_gene836 5.935e-05 52.0 COG1633@1|root,COG1633@2|Bacteria,1NEYR@1224|Proteobacteria,42VA3@68525|delta/epsilon subdivisions,2WS93@28221|Deltaproteobacteria,43SR0@69541|Desulfuromonadales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD3_k127_5139976_0 1279009.ADICEAN_01234 1.501e-139 458.0 COG0624@1|root,COG0624@2|Bacteria,4NFGE@976|Bacteroidetes,47JN6@768503|Cytophagia 976|Bacteroidetes E PFAM Peptidase family M20 M25 M40 dapE - - - - - - - - - - - M20_dimer,Peptidase_M20 YYD3_k127_5139976_1 1379270.AUXF01000007_gene866 9.028e-65 231.0 COG1028@1|root,COG1028@2|Bacteria,1ZTIT@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 YYD3_k127_5139976_2 1242864.D187_000455 3.68e-43 169.0 COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,42MGR@68525|delta/epsilon subdivisions,2X5KV@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA YYD3_k127_5139976_4 661478.OP10G_2386 6.595e-32 136.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - Polyketide_cyc2 YYD3_k127_5151234_7 696281.Desru_2964 2.847e-58 210.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,261JB@186807|Peptococcaceae 186801|Clostridia J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 YYD3_k127_5151234_2 1379698.RBG1_1C00001G0485 2.188e-86 295.0 COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria 2|Bacteria C Electron transfer flavoprotein fixB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 ko:K03522,ko:K22432 - - - - ko00000,ko01000,ko04147 - - iAF987.Gmet_2066,iAF987.Gmet_2257 ETF,ETF_alpha,Fer4 YYD3_k127_5151234_3 1379698.RBG1_1C00001G0481 4.686e-85 287.0 COG1716@1|root,COG1716@2|Bacteria,2NQ4X@2323|unclassified Bacteria 2|Bacteria T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - DUF3662,DUF4388,FHA,Yop-YscD_cpl YYD3_k127_5151234_6 1499967.BAYZ01000167_gene6734 1.417e-58 212.0 COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria 2|Bacteria T Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 YYD3_k127_5151234_1 1379698.RBG1_1C00001G0479 5.47e-160 533.0 COG0515@1|root,COG0515@2|Bacteria 1379698.RBG1_1C00001G0479|- KLT protein kinase activity - - - - - - - - - - - - - YYD3_k127_5151234_0 518766.Rmar_0089 5.343e-215 698.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1FIP6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C YYD3_k127_5151234_5 580331.Thit_0218 1.054e-60 218.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,42FTY@68295|Thermoanaerobacterales 186801|Clostridia V Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD3_k127_5151234_8 1519464.HY22_12335 1.739e-52 203.0 COG4591@1|root,COG4591@2|Bacteria,1FECJ@1090|Chlorobi 1090|Chlorobi M MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD YYD3_k127_5151234_4 1356852.N008_09000 3.139e-76 274.0 COG1409@1|root,COG3419@1|root,COG1409@2|Bacteria,COG3419@2|Bacteria 2|Bacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - 3.1.3.2 ko:K02674,ko:K14379 ko00740,ko01100,ko04142,ko04380,ko05323,map00740,map01100,map04142,map04380,map05323 - R00548 RC00017 ko00000,ko00001,ko01000,ko02035,ko02044 - - - CarboxypepD_reg,Metallophos,Neisseria_PilC YYD3_k127_5151234_9 1123508.JH636443_gene5018 1.34e-13 72.0 COG3324@1|root,COG3324@2|Bacteria,2J3W8@203682|Planctomycetes 203682|Planctomycetes S Glyoxalase-like domain - - - ko:K06996 - - - - ko00000 - - - - YYD3_k127_5180372_8 1174528.JH992898_gene4175 2.1e-06 57.0 COG1716@1|root,COG1716@2|Bacteria,1G7WQ@1117|Cyanobacteria 1117|Cyanobacteria T ATPase activity - - - - - - - - - - - - - YYD3_k127_5180372_6 96561.Dole_0805 4.621e-26 115.0 COG1309@1|root,COG1309@2|Bacteria,1RCDH@1224|Proteobacteria,42VJ5@68525|delta/epsilon subdivisions,2WRC7@28221|Deltaproteobacteria,2MKUA@213118|Desulfobacterales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_3,TetR_N YYD3_k127_5180372_7 1114964.L485_18340 2.131e-11 76.0 COG1538@1|root,COG1538@2|Bacteria,1R8ES@1224|Proteobacteria,2TRDW@28211|Alphaproteobacteria,2K3AV@204457|Sphingomonadales 204457|Sphingomonadales MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP YYD3_k127_5180372_5 96561.Dole_0807 6.43e-51 191.0 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43BPM@68525|delta/epsilon subdivisions,2X70W@28221|Deltaproteobacteria 28221|Deltaproteobacteria V PFAM secretion protein HlyD family protein ybhG - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 YYD3_k127_5180372_4 338969.Rfer_0860 2.813e-75 265.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,4AJWS@80864|Comamonadaceae 28216|Betaproteobacteria V pfam abc - - - ko:K01990,ko:K13926 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_tran YYD3_k127_5180372_1 290318.Cvib_0861 3.26e-88 297.0 COG1131@1|root,COG1131@2|Bacteria,1FDTT@1090|Chlorobi 1090|Chlorobi V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD3_k127_5180372_2 96561.Dole_0810 1.103e-83 290.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42P7V@68525|delta/epsilon subdivisions,2WJQA@28221|Deltaproteobacteria,2MJ2Q@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein ybhS - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 YYD3_k127_5180372_3 96561.Dole_0811 3.389e-76 269.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria,2MJ98@213118|Desulfobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 YYD3_k127_5180372_0 716544.wcw_0742 2.299e-94 317.0 COG1090@1|root,COG1090@2|Bacteria,2JFV6@204428|Chlamydiae 204428|Chlamydiae S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase YYD3_k127_5187163_1 880073.Calab_1665 1.674e-37 151.0 COG0697@1|root,COG0697@2|Bacteria,2NPZZ@2323|unclassified Bacteria 2|Bacteria EG EamA-like transporter family pagO - - ko:K07790 ko02020,map02020 - - - ko00000,ko00001 2.A.7 - - EamA YYD3_k127_5187163_0 1379698.RBG1_1C00001G0988 1.213e-65 246.0 COG1413@1|root,COG1413@2|Bacteria,2NQWQ@2323|unclassified Bacteria 2|Bacteria C lyase activity - - 3.4.24.3 ko:K01387,ko:K03301 - - - - ko00000,ko01000,ko01002,ko02042 2.A.12 - - DUF1822,DUF4132,HEAT_2,HEAT_PBS,Peptidase_M9,Peptidase_M9_N,Sulfatase YYD3_k127_5188925_0 1121918.ARWE01000001_gene2845 5.479e-50 190.0 COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,42QVG@68525|delta/epsilon subdivisions,2WNKA@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA YYD3_k127_5188925_1 269799.Gmet_1014 2.291e-09 59.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP-2 - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 YYD3_k127_5203104_3 398767.Glov_1947 1.324e-25 109.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,43BTG@68525|delta/epsilon subdivisions,2X74B@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA polymerase III, delta' holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C YYD3_k127_5203104_2 335541.Swol_0642 3.706e-27 118.0 COG4359@1|root,COG4359@2|Bacteria,1TSZ9@1239|Firmicutes,24IHI@186801|Clostridia,42KRZ@68298|Syntrophomonadaceae 186801|Clostridia E Putative Phosphatase mtnX - - - - - - - - - - - HAD,Put_Phosphatase YYD3_k127_5203104_0 1519464.HY22_12340 5.715e-237 759.0 COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1FEI3@1090|Chlorobi 1090|Chlorobi GJM Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III YYD3_k127_5203104_1 373903.Hore_08140 5.159e-200 632.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,3WABP@53433|Halanaerobiales 186801|Clostridia J class II (D K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon YYD3_k127_5203104_4 1123504.JQKD01000041_gene2850 2.644e-14 76.0 COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,2VVXU@28216|Betaproteobacteria,4AFCI@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Transglycosylase-associated protein - - - - - - - - - - - - Transgly_assoc YYD3_k127_5210292_0 1379698.RBG1_1C00001G1604 0.0 1960.0 COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 YYD3_k127_5210292_1 880073.Calab_2119 0.0 1487.0 COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 YYD3_k127_5210292_5 635013.TherJR_0286 5.831e-37 143.0 COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,26263@186807|Peptococcaceae 186801|Clostridia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N YYD3_k127_5210292_6 555088.DealDRAFT_1533 8.02e-34 136.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,42K2J@68298|Syntrophomonadaceae 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 YYD3_k127_5210292_2 1379698.RBG1_1C00001G1608 3.273e-85 287.0 COG0081@1|root,COG0081@2|Bacteria,2NNK6@2323|unclassified Bacteria 2|Bacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 YYD3_k127_5210292_4 316067.Geob_3636 7.719e-59 207.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,42RE7@68525|delta/epsilon subdivisions,2WNAH@28221|Deltaproteobacteria,43UTJ@69541|Desulfuromonadales 28221|Deltaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N YYD3_k127_5210292_3 1379698.RBG1_1C00001G1610 3.937e-77 261.0 COG0250@1|root,COG0250@2|Bacteria,2NPAP@2323|unclassified Bacteria 2|Bacteria K Participates in transcription elongation, termination and antitermination nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG YYD3_k127_5210292_8 1150626.PHAMO_320002 7.884e-12 68.0 COG0690@1|root,COG0690@2|Bacteria,1N75P@1224|Proteobacteria,2UF51@28211|Alphaproteobacteria,2JTWP@204441|Rhodospirillales 204441|Rhodospirillales U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE YYD3_k127_5210292_7 861299.J421_2760 2.564e-17 82.0 COG0267@1|root,COG0267@2|Bacteria,1ZV8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein L33 - - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 YYD3_k127_5212635_0 1125863.JAFN01000001_gene2253 7.283e-82 285.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_5212635_2 1254432.SCE1572_32910 3.481e-28 132.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2WJNS@28221|Deltaproteobacteria,2Z3JN@29|Myxococcales 28221|Deltaproteobacteria KLT GAF domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,Pkinase YYD3_k127_5212635_1 1144313.PMI10_00587 2.827e-38 148.0 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes,1I2T3@117743|Flavobacteriia,2NVZM@237|Flavobacterium 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 YYD3_k127_5223619_3 880073.Calab_0041 5.775e-23 114.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase YYD3_k127_5223619_2 1379698.RBG1_1C00001G0098 1.359e-31 127.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - Response_reg YYD3_k127_5223619_0 945713.IALB_2869 6.515e-103 346.0 COG2262@1|root,COG2262@2|Bacteria 2|Bacteria O GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 YYD3_k127_5223619_1 1379698.RBG1_1C00001G0290 1.526e-40 172.0 COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 YYD3_k127_5267173_5 1379698.RBG1_1C00001G1004 5.522e-48 180.0 COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria 2|Bacteria D Peptidoglycan polymerase that is essential for cell wall elongation rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE YYD3_k127_5267173_0 1379698.RBG1_1C00001G1003 5.165e-146 484.0 COG0768@1|root,COG0768@2|Bacteria,2NNYI@2323|unclassified Bacteria 2|Bacteria M Penicillin-binding protein 2 mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase YYD3_k127_5267173_7 1321781.HMPREF1985_02178 4.129e-31 132.0 COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,4H2TV@909932|Negativicutes 909932|Negativicutes M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC YYD3_k127_5267173_3 1379698.RBG1_1C00001G1000 1.019e-58 207.0 COG1762@1|root,COG1762@2|Bacteria,2NPVC@2323|unclassified Bacteria 2|Bacteria G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2 YYD3_k127_5267173_8 1125863.JAFN01000001_gene531 1.497e-15 77.0 COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p YYD3_k127_5267173_1 1379698.RBG1_1C00001G0998 2.897e-124 415.0 COG0825@1|root,COG0825@2|Bacteria,2NNVQ@2323|unclassified Bacteria 2|Bacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iJN678.accA ACCA YYD3_k127_5267173_4 1286171.EAL2_c03820 8.799e-54 202.0 COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,25UW9@186806|Eubacteriaceae 186801|Clostridia M Glycosyl transferase family 4 tagO - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 YYD3_k127_5267173_6 1206730.BAGA01000184_gene3108 8.99e-35 145.0 COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4FVK3@85025|Nocardiaceae 201174|Actinobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 YYD3_k127_5267173_2 1379698.RBG1_1C00001G0996 1.702e-71 245.0 COG0463@1|root,COG0463@2|Bacteria,2NS3Y@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 dpm1 - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 YYD3_k127_5272935_1 497964.CfE428DRAFT_5644 1.212e-34 151.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,46UMD@74201|Verrucomicrobia 2|Bacteria O Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_8 YYD3_k127_5272935_0 1379698.RBG1_1C00001G0581 9.928e-57 215.0 COG2911@1|root,COG2911@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - - - - - - - - - - - ASH,Cohesin,FlgD_ig,Peptidase_S74 YYD3_k127_5298523_13 926569.ANT_31450 7.298e-06 50.0 COG1575@1|root,COG1575@2|Bacteria,2G5ZC@200795|Chloroflexi 200795|Chloroflexi H Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA YYD3_k127_5298523_5 517418.Ctha_1986 2.502e-52 201.0 COG4948@1|root,COG4948@2|Bacteria,1FE1S@1090|Chlorobi 1090|Chlorobi H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C YYD3_k127_5298523_1 42256.RradSPS_2309 2.203e-102 350.0 COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4CPCU@84995|Rubrobacteria 84995|Rubrobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C YYD3_k127_5298523_8 1437425.CSEC_1883 3.132e-28 119.0 COG0824@1|root,COG0824@2|Bacteria,2JG70@204428|Chlamydiae 204428|Chlamydiae S Acyl-ACP thioesterase - - 3.1.2.28 ko:K12073 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07262 RC00004,RC00174 ko00000,ko00001,ko00002,ko01000 - - - 4HBT_2 YYD3_k127_5298523_0 1304284.L21TH_0121 2.725e-178 579.0 COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia,36DG9@31979|Clostridiaceae 186801|Clostridia E oligoendopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N YYD3_k127_5298523_4 1397527.Q670_09385 1.981e-52 200.0 COG3391@1|root,COG5184@1|root,COG5276@1|root,COG3391@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria,1QUHA@1224|Proteobacteria,1T1YV@1236|Gammaproteobacteria,1XS25@135619|Oceanospirillales 135619|Oceanospirillales DZ Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 YYD3_k127_5298523_9 1379698.RBG1_1C00001G1377 3.016e-14 87.0 COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase YYD3_k127_5298523_3 1232410.KI421413_gene750 1.667e-54 217.0 COG2885@1|root,COG3210@1|root,COG5184@1|root,COG5276@1|root,COG2885@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria 28221|Deltaproteobacteria DZ Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 YYD3_k127_5298523_2 865937.Gilli_0418 8.799e-91 330.0 COG3188@1|root,COG3188@2|Bacteria,4NFPY@976|Bacteroidetes,1HXS8@117743|Flavobacteriia,2P5CG@244698|Gillisia 976|Bacteroidetes NU usher protein - - - - - - - - - - - - - YYD3_k127_5298523_6 379066.GAU_1023 7.067e-31 132.0 COG3121@1|root,COG3121@2|Bacteria 2|Bacteria NU pilus organization - - - - - - - - - - - - ASH,AhpC-TSA,Calx-beta,HemolysinCabind,LVIVD,PPC,PapD_N,Peptidase_S8 YYD3_k127_5298523_7 717231.Flexsi_2157 8.209e-30 124.0 COG1528@1|root,COG1528@2|Bacteria,2GFDZ@200930|Deferribacteres 200930|Deferribacteres C Iron-storage protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin YYD3_k127_5317759_3 382464.ABSI01000006_gene764 2.082e-32 136.0 COG3794@1|root,COG3794@2|Bacteria,46SUG@74201|Verrucomicrobia,2IVQT@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Carboxypeptidase regulatory-like domain - - - - - - - - - - - - - YYD3_k127_5317759_4 1184267.A11Q_2332 6.991e-31 134.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2MUQI@213481|Bdellovibrionales,2WM7E@28221|Deltaproteobacteria 213481|Bdellovibrionales M PFAM NAD-dependent epimerase dehydratase dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - 3Beta_HSD,Epimerase YYD3_k127_5317759_6 288000.BBta_0913 0.0002845 49.0 2AMTY@1|root,31CQG@2|Bacteria,1P3P3@1224|Proteobacteria,2UURA@28211|Alphaproteobacteria,3K4UJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_5317759_2 595460.RRSWK_01928 1.928e-55 215.0 COG0515@1|root,COG0515@2|Bacteria,2IWUD@203682|Planctomycetes 203682|Planctomycetes T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_10,WD40 YYD3_k127_5317759_0 1379698.RBG1_1C00001G0921 1.825e-67 233.0 COG2169@1|root,COG2169@2|Bacteria,2NRJ0@2323|unclassified Bacteria 2|Bacteria K Metal binding domain of Ada adaA1 - 2.1.1.63,3.2.2.21 ko:K10778,ko:K13529,ko:K13530,ko:K15051 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,Endonuclea_NS_2,HTH_18,HhH-GPD YYD3_k127_5317759_1 1379698.RBG1_1C00001G0922 8.879e-62 219.0 COG0350@1|root,COG0350@2|Bacteria,2NPJ5@2323|unclassified Bacteria 2|Bacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ada - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N YYD3_k127_5317759_5 1192034.CAP_6222 8.595e-18 85.0 COG3832@1|root,COG3832@2|Bacteria,1N4FU@1224|Proteobacteria,437UM@68525|delta/epsilon subdivisions,2WZ0K@28221|Deltaproteobacteria,2Z12N@29|Myxococcales 28221|Deltaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 YYD3_k127_539008_6 8364.ENSXETP00000046997 6.951e-24 118.0 28HX2@1|root,2QQ7Z@2759|Eukaryota,38DFP@33154|Opisthokonta,3BGZ5@33208|Metazoa,3CUDF@33213|Bilateria,482B1@7711|Chordata,496EG@7742|Vertebrata 33208|Metazoa T response to follicle-stimulating hormone PAPPA GO:0000003,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0007565,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016787,GO:0019538,GO:0022414,GO:0031960,GO:0032501,GO:0033993,GO:0042221,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044703,GO:0044706,GO:0046872,GO:0046914,GO:0048545,GO:0050896,GO:0051384,GO:0051704,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.24.79 ko:K07762,ko:K08647 - - - - ko00000,ko01000,ko01002 - - - Laminin_G_3,Notch,Peptidase_M43,Sushi YYD3_k127_539008_8 521011.Mpal_2204 6.549e-08 66.0 COG3291@1|root,arCOG02498@1|root,arCOG02498@2157|Archaea,arCOG02508@2157|Archaea 2157|Archaea G PFAM PKD domain containing protein - - - - - - - - - - - - Beta_helix,NosD,PKD YYD3_k127_539008_4 670487.Ocepr_1445 5.871e-32 137.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1WIRD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans YYD3_k127_539008_3 880073.Calab_2071 5.973e-49 202.0 COG1361@1|root,COG1404@1|root,COG1520@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG1520@2|Bacteria,2NQX6@2323|unclassified Bacteria 2|Bacteria O SPTR Peptidase S8 and S53 subtilisin kexin sedolisin - - 3.1.3.1 ko:K01113,ko:K14645,ko:K17713 ko00790,ko01100,ko02020,ko02024,map00790,map01100,map02020,map02024 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03110 1.B.33.1 - - PKD,Peptidase_S8,SBBP YYD3_k127_539008_5 880073.Calab_2081 1.273e-27 130.0 COG3291@1|root,COG5276@1|root,COG3291@2|Bacteria,COG5276@2|Bacteria,2NQ2P@2323|unclassified Bacteria 2|Bacteria P LVIVD repeat - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - LVIVD YYD3_k127_539008_1 864051.BurJ1DRAFT_3700 1.727e-54 218.0 COG0726@1|root,COG0823@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3420@1|root,COG0726@2|Bacteria,COG0823@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3420@2|Bacteria,1MU7T@1224|Proteobacteria,2WI67@28216|Betaproteobacteria,1KMDS@119065|unclassified Burkholderiales 28216|Betaproteobacteria MQU Domain of unknown function (DUF4347) - - - - - - - - - - - - DUF4347 YYD3_k127_539008_7 1191523.MROS_2238 1.006e-22 115.0 COG4733@1|root,COG4733@2|Bacteria 2|Bacteria S cellulase activity - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - CBM_6,fn3 YYD3_k127_539008_2 502025.Hoch_6859 1.595e-49 181.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,42SRT@68525|delta/epsilon subdivisions,2WPB8@28221|Deltaproteobacteria,2YV8N@29|Myxococcales 28221|Deltaproteobacteria S EVE domain - - - - - - - - - - - - EVE YYD3_k127_539008_0 867845.KI911784_gene362 1.582e-94 336.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - P_proprotein,Peptidase_S8,SLH,fn3 YYD3_k127_5418191_2 1165096.ARWF01000001_gene2231 2.094e-10 72.0 COG3187@1|root,COG3187@2|Bacteria,1MXIV@1224|Proteobacteria 1224|Proteobacteria O Heat shock protein - - - ko:K03668 - - - - ko00000 - - - META,MliC,YscW YYD3_k127_5418191_3 287.DR97_879 1.557e-09 69.0 COG3650@1|root,COG3650@2|Bacteria,1N019@1224|Proteobacteria,1SBAD@1236|Gammaproteobacteria,1YG4W@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S response to hydrogen peroxide - - - ko:K08985 - - - - ko00000 - - - MliC,YscW YYD3_k127_5418191_1 518766.Rmar_2453 4.451e-28 120.0 COG0789@1|root,COG0789@2|Bacteria,4NW77@976|Bacteroidetes,1FK6E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K MerR, DNA binding - - - ko:K19591 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR_1 YYD3_k127_5418191_0 1125863.JAFN01000001_gene1462 4.7e-310 969.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS YYD3_k127_5418235_0 251221.35214536 1.263e-192 625.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1G4UJ@1117|Cyanobacteria 1117|Cyanobacteria CO Disulphide bond corrector protein DsbC - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 YYD3_k127_5418235_1 1519464.HY22_10020 2.424e-51 186.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity putP - - ko:K03307,ko:K14387 ko04725,ko05231,map04725,map05231 - - - ko00000,ko00001,ko02000 2.A.21,2.A.21.8 - - SSF YYD3_k127_5455479_1 1090319.KE386571_gene3235 3.224e-27 113.0 COG2827@1|root,COG2827@2|Bacteria,1MZME@1224|Proteobacteria,2UCNX@28211|Alphaproteobacteria,2K6CR@204457|Sphingomonadales 204457|Sphingomonadales L GIY-YIG catalytic domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG YYD3_k127_5455479_0 1379698.RBG1_1C00001G0102 2.204e-77 266.0 COG0005@1|root,COG0005@2|Bacteria,2NP5F@2323|unclassified Bacteria 2|Bacteria F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 YYD3_k127_5461697_2 903818.KI912269_gene239 5.95e-39 150.0 COG0436@1|root,COG0436@2|Bacteria,3Y5C9@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class I and II - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_5461697_6 338966.Ppro_2697 3.025e-20 96.0 COG1430@1|root,COG1430@2|Bacteria,1N7U4@1224|Proteobacteria,42VKG@68525|delta/epsilon subdivisions,2WSD0@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 YYD3_k127_5461697_8 926566.Terro_3894 3.691e-06 51.0 COG3847@1|root,COG3847@2|Bacteria,3Y5Y3@57723|Acidobacteria 57723|Acidobacteria U PFAM Flp Fap pilin component - - - ko:K02651 ko04112,map04112 - - - ko00000,ko00001,ko02035,ko02044 - - - Flp_Fap YYD3_k127_5461697_10 926566.Terro_3894 3.134e-05 48.0 COG3847@1|root,COG3847@2|Bacteria,3Y5Y3@57723|Acidobacteria 57723|Acidobacteria U PFAM Flp Fap pilin component - - - ko:K02651 ko04112,map04112 - - - ko00000,ko00001,ko02035,ko02044 - - - Flp_Fap YYD3_k127_5461697_5 1121406.JAEX01000002_gene912 7.73e-28 119.0 COG1989@1|root,COG1989@2|Bacteria,1R34X@1224|Proteobacteria,42V6M@68525|delta/epsilon subdivisions,2WRP6@28221|Deltaproteobacteria,2MCVZ@213115|Desulfovibrionales 28221|Deltaproteobacteria NOU PFAM Peptidase A24A, prepilin type IV - - 3.4.23.43 ko:K02278 - - - - ko00000,ko01000,ko02035,ko02044 - - - Peptidase_A24 YYD3_k127_5461697_7 1089553.Tph_c05460 1.545e-09 65.0 COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,42H5Q@68295|Thermoanaerobacterales 186801|Clostridia U TadE-like protein - - - - - - - - - - - - TadE YYD3_k127_5461697_4 1238182.C882_0871 3.47e-32 137.0 COG3745@1|root,COG3745@2|Bacteria,1MYVE@1224|Proteobacteria,2V9JX@28211|Alphaproteobacteria,2JWBX@204441|Rhodospirillales 204441|Rhodospirillales U Flp pilus assembly protein RcpC/CpaB - - - - - - - - - - - - RcpC,SAF YYD3_k127_5461697_1 13689.BV96_00405 1.628e-53 203.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2U4KB@28211|Alphaproteobacteria,2K1M8@204457|Sphingomonadales 204457|Sphingomonadales U Belongs to the GSP D family - - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N YYD3_k127_5461697_3 596151.DesfrDRAFT_0992 6.444e-39 160.0 COG4961@1|root,COG4961@2|Bacteria,1NIG7@1224|Proteobacteria,42X7K@68525|delta/epsilon subdivisions,2WSKV@28221|Deltaproteobacteria,2M9N1@213115|Desulfovibrionales 28221|Deltaproteobacteria U Putative Flp pilus-assembly TadE/G-like - - - - - - - - - - - - Tad YYD3_k127_5461697_0 443143.GM18_2436 4.008e-54 207.0 COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,43SJ6@69541|Desulfuromonadales 28221|Deltaproteobacteria D Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,CBP_BcsQ,ParA,Response_reg YYD3_k127_5461697_9 443143.GM18_2435 1.043e-05 51.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,43SA4@69541|Desulfuromonadales 28221|Deltaproteobacteria U PFAM type II secretion system protein E - - - ko:K02283,ko:K03609 - - - - ko00000,ko02035,ko02044,ko03036,ko04812 - - - CbiA,FHA,T2SSE YYD3_k127_5477408_1 448385.sce3387 2.261e-73 267.0 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - YYD3_k127_5477408_0 926569.ANT_27030 1.235e-161 533.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi 200795|Chloroflexi EU PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 YYD3_k127_5477408_2 1267535.KB906767_gene607 1.955e-66 247.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,3Y34Y@57723|Acidobacteria,2JHQ9@204432|Acidobacteriia 204432|Acidobacteriia C Dehydrogenase E1 component - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C YYD3_k127_5479285_5 298653.Franean1_2466 2.203e-07 57.0 2EGQV@1|root,33AH0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_5479285_4 1229780.BN381_130143 1.989e-11 65.0 2DREZ@1|root,33BFB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_5479285_0 1123242.JH636435_gene2052 1.305e-119 400.0 COG0475@1|root,COG0475@2|Bacteria,2IZ8F@203682|Planctomycetes 203682|Planctomycetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger YYD3_k127_5479285_1 240015.ACP_2713 2.172e-91 308.0 COG1291@1|root,COG1291@2|Bacteria,3Y3Y8@57723|Acidobacteria,2JI9S@204432|Acidobacteriia 204432|Acidobacteriia N MotA/TolQ/ExbB proton channel family - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB YYD3_k127_5479285_2 909663.KI867150_gene569 1.32e-60 219.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,42S6Q@68525|delta/epsilon subdivisions,2WNX0@28221|Deltaproteobacteria,2MRWK@213462|Syntrophobacterales 28221|Deltaproteobacteria N Membrane MotB of proton-channel complex MotA/MotB - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA YYD3_k127_5479285_3 1379698.RBG1_1C00001G0707 9.614e-48 181.0 COG1197@1|root,COG1197@2|Bacteria,2NNMM@2323|unclassified Bacteria 2|Bacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - 2.4.1.129,3.4.16.4 ko:K03723,ko:K05365 ko00550,ko03420,map00550,map03420 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011,ko03400 - GT51 - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF YYD3_k127_5487048_0 1379698.RBG1_1C00001G1194 1.94e-76 290.0 COG2911@1|root,COG3291@1|root,COG3391@1|root,COG4932@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2NNYR@2323|unclassified Bacteria 2|Bacteria M FlgD Ig-like domain - - 3.2.1.91 ko:K14194,ko:K19668 ko00500,ko01100,ko02020,ko05150,map00500,map01100,map02020,map05150 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CHU_C,DUF11,FlgD_ig,PKD,SdrD_B YYD3_k127_5487048_3 868595.Desca_2712 8.22e-25 109.0 COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,2620E@186807|Peptococcaceae 186801|Clostridia J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase YYD3_k127_5487048_2 635013.TherJR_1960 2.021e-44 167.0 COG0432@1|root,COG0432@2|Bacteria,1V6J7@1239|Firmicutes,24J8G@186801|Clostridia,2623P@186807|Peptococcaceae 186801|Clostridia S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 YYD3_k127_5487048_1 1121468.AUBR01000030_gene1228 1.326e-48 176.0 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,42ENW@68295|Thermoanaerobacterales 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N YYD3_k127_5500529_4 880073.Calab_1610 1.825e-15 77.0 COG0484@1|root,COG0484@2|Bacteria,2NQUM@2323|unclassified Bacteria 2|Bacteria O Class III cytochrome C family - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - - - - - - - - - - Cytochrom_CIII,Cytochrom_c3_2 YYD3_k127_5500529_5 1219084.AP014508_gene686 2.731e-15 81.0 COG1832@1|root,COG1832@2|Bacteria,2GDCX@200918|Thermotogae 200918|Thermotogae S PFAM CoA-binding domain protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 YYD3_k127_5500529_2 1403819.BATR01000133_gene4708 2.027e-71 244.0 COG3832@1|root,COG3832@2|Bacteria,46SRI@74201|Verrucomicrobia,2IVPS@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 YYD3_k127_5500529_0 926549.KI421517_gene2964 1.194e-201 649.0 COG3590@1|root,COG3590@2|Bacteria,4NEYB@976|Bacteroidetes,47JHJ@768503|Cytophagia 976|Bacteroidetes O PFAM peptidase M13 pepO - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N YYD3_k127_5500529_1 1123073.KB899241_gene2325 1.247e-95 318.0 COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,1S0J9@1236|Gammaproteobacteria,1X3D8@135614|Xanthomonadales 135614|Xanthomonadales U Involved in the import of queuosine (Q) precursors, required for Q precursor salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 YYD3_k127_5500529_3 290397.Adeh_2802 3.317e-20 92.0 2EK70@1|root,33DXD@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_5500529_6 96561.Dole_1704 1.311e-07 58.0 COG3420@1|root,COG3420@2|Bacteria,1MZHI@1224|Proteobacteria,43BRC@68525|delta/epsilon subdivisions,2WUM4@28221|Deltaproteobacteria,2MN6K@213118|Desulfobacterales 1224|Proteobacteria P Parallel beta-helix repeats - - - - - - - - - - - - - YYD3_k127_5520586_1 1173020.Cha6605_5395 5.061e-61 227.0 COG1169@1|root,COG1169@2|Bacteria,1G2H4@1117|Cyanobacteria 1117|Cyanobacteria HQ Isochorismate synthase menF - 5.4.4.2 ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind YYD3_k127_5520586_0 331113.SNE_A14190 1.329e-71 249.0 COG0500@1|root,COG2226@2|Bacteria,2JG4F@204428|Chlamydiae 204428|Chlamydiae H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran YYD3_k127_5520586_2 648757.Rvan_1397 2.389e-20 92.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria 1224|Proteobacteria S oligopeptide transporter - - - - - - - - - - - - OPT YYD3_k127_552238_4 1379698.RBG1_1C00001G1143 9.884e-18 83.0 COG0776@1|root,COG0776@2|Bacteria,2NPU6@2323|unclassified Bacteria 2|Bacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup_1 - - ko:K03530,ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding YYD3_k127_552238_2 1379698.RBG1_1C00001G1142 1.966e-73 257.0 COG0616@1|root,COG0616@2|Bacteria,2NPIE@2323|unclassified Bacteria 2|Bacteria OU Peptidase family S49 sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 YYD3_k127_552238_1 1379698.RBG1_1C00001G1141 8.988e-117 403.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria 2|Bacteria M Transglycosylase SLT domain CP_0155 - - ko:K08307,ko:K12204 - - - - ko00000,ko01000,ko01011,ko02044 3.A.7.10.1,3.A.7.9.1 - - LysM,SLT,T4SS_TraI YYD3_k127_552238_3 1499967.BAYZ01000008_gene5426 2.834e-70 250.0 COG0324@1|root,COG0324@2|Bacteria,2NP6D@2323|unclassified Bacteria 2|Bacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT YYD3_k127_552238_0 1379698.RBG1_1C00001G1139 4.118e-118 400.0 COG0323@1|root,COG0323@2|Bacteria,2NNP7@2323|unclassified Bacteria 2|Bacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C YYD3_k127_5529512_3 521674.Plim_3803 3.489e-16 82.0 COG0019@1|root,COG0019@2|Bacteria,2J1SY@203682|Planctomycetes 203682|Planctomycetes E Pyridoxal-dependent decarboxylase, C-terminal sheet domain - - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC YYD3_k127_5529512_2 1150474.JQJI01000023_gene777 2.819e-42 159.0 COG1586@1|root,COG1586@2|Bacteria,2GCWX@200918|Thermotogae 200918|Thermotogae F Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speH - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc YYD3_k127_5529512_1 404380.Gbem_2919 1.351e-52 191.0 COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1RCYA@1224|Proteobacteria,42QGN@68525|delta/epsilon subdivisions,2WIZH@28221|Deltaproteobacteria 28221|Deltaproteobacteria K transcriptional regulator - - - - - - - - - - - - Cupin_2,HTH_19,HTH_3 YYD3_k127_5529512_0 330214.NIDE2727 3.88e-122 406.0 COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae 40117|Nitrospirae C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim YYD3_k127_5538591_1 555088.DealDRAFT_1412 1.662e-41 162.0 COG2120@1|root,COG2120@2|Bacteria,1TUFP@1239|Firmicutes,25PKR@186801|Clostridia,42KY4@68298|Syntrophomonadaceae 186801|Clostridia S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L YYD3_k127_5538591_2 1379698.RBG1_1C00001G0661 1.885e-14 83.0 COG0627@1|root,COG0627@2|Bacteria,2NQQ3@2323|unclassified Bacteria 2|Bacteria S Putative esterase - - - - - - - - - - - - Esterase YYD3_k127_5550432_2 234267.Acid_5940 9.847e-65 240.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase YYD3_k127_5550432_0 1121930.AQXG01000008_gene165 8.882e-89 304.0 COG0820@1|root,COG0820@2|Bacteria,4NFH5@976|Bacteroidetes,1IQMY@117747|Sphingobacteriia 976|Bacteroidetes J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM YYD3_k127_5550432_3 1121355.KB903379_gene745 6.674e-06 50.0 COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae 201174|Actinobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N YYD3_k127_5550432_1 745411.B3C1_17017 8.022e-74 265.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1J4GR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J SAM-dependent methyltransferases rlmI GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM YYD3_k127_5550996_17 379066.GAU_0359 3.705e-09 65.0 2F57Y@1|root,33XUE@2|Bacteria,1ZTSK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - YYD3_k127_5550996_1 118005.AWNK01000006_gene1181 3.805e-168 550.0 COG0643@1|root,COG0643@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg YYD3_k127_5550996_3 518766.Rmar_0772 7.75e-115 381.0 COG2201@1|root,COG2201@2|Bacteria,4NHMU@976|Bacteroidetes,1FJZC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg YYD3_k127_5550996_9 1379698.RBG1_1C00001G1275 7.36e-72 259.0 COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria 2|Bacteria T Signal transduction histidine kinase, nitrogen specific, NtrB atoS - 2.7.13.3 ko:K07708,ko:K07710,ko:K10942 ko02020,ko05111,map02020,map05111 M00497,M00500,M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_8,PAS_9 YYD3_k127_5550996_2 1379698.RBG1_1C00001G1274 4.397e-151 490.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family atoC - - ko:K07712,ko:K07713,ko:K07714,ko:K10943 ko02020,ko05111,map02020,map05111 M00497,M00499,M00500,M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_5550996_7 909663.KI867150_gene1996 9.454e-80 274.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,42PR1@68525|delta/epsilon subdivisions,2WIQ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria N PFAM MotA TolQ ExbB proton channel motA - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB YYD3_k127_5550996_10 643648.Slip_1876 1.515e-58 213.0 COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia,42K2U@68298|Syntrophomonadaceae 186801|Clostridia N OmpA family motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA YYD3_k127_5550996_19 1127673.GLIP_2549 0.0002042 49.0 COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,1S9DS@1236|Gammaproteobacteria,467QG@72275|Alteromonadaceae 1236|Gammaproteobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod YYD3_k127_5550996_12 373903.Hore_16910 1.181e-33 135.0 COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,24JJW@186801|Clostridia,3WBUF@53433|Halanaerobiales 186801|Clostridia N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C YYD3_k127_5550996_16 398512.JQKC01000007_gene1149 5.997e-13 73.0 COG1677@1|root,COG1677@2|Bacteria,1VEEY@1239|Firmicutes,24R4F@186801|Clostridia,3WKN2@541000|Ruminococcaceae 186801|Clostridia N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE YYD3_k127_5550996_6 1191523.MROS_2129 4.353e-97 336.0 COG1766@1|root,COG1766@2|Bacteria 2|Bacteria N bacterial-type flagellum-dependent cell motility fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C YYD3_k127_5550996_4 1449126.JQKL01000001_gene1325 5.546e-102 342.0 COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia,267T2@186813|unclassified Clostridiales 186801|Clostridia N FliG C-terminal domain fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N YYD3_k127_5550996_15 1125863.JAFN01000001_gene699 1.213e-18 96.0 COG1317@1|root,COG1317@2|Bacteria,1NJAJ@1224|Proteobacteria,42P5I@68525|delta/epsilon subdivisions,2WSGD@28221|Deltaproteobacteria 28221|Deltaproteobacteria N PFAM Flagellar assembly protein FliH fliH - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH YYD3_k127_5550996_0 1123288.SOV_1c11670 2.737e-169 542.0 COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,4H2V3@909932|Negativicutes 909932|Negativicutes N Flagellar protein export ATPase FliI fliI - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N YYD3_k127_5550996_20 1282887.AUJG01000007_gene2399 0.0004662 49.0 COG2882@1|root,COG2882@2|Bacteria,1VK96@1239|Firmicutes,24RWK@186801|Clostridia 186801|Clostridia NOU flagellar export protein FliJ fliJ - - ko:K02413 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliJ YYD3_k127_5550996_13 880073.Calab_0041 1.351e-24 118.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase YYD3_k127_5550996_11 1009370.ALO_10009 1.631e-40 159.0 COG4786@1|root,COG4786@2|Bacteria,1TRFQ@1239|Firmicutes,4H3AU@909932|Negativicutes 909932|Negativicutes N flagellar basal-body rod protein - - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C YYD3_k127_5550996_5 760142.Hipma_0728 4.712e-100 332.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2WJDN@28221|Deltaproteobacteria,2M6GB@213113|Desulfurellales 28221|Deltaproteobacteria N Flagellar basal body rod FlgEFG protein C-terminal flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C YYD3_k127_5550996_18 1192868.CAIU01000025_gene3600 0.0001485 52.0 COG1261@1|root,COG1261@2|Bacteria,1MZIR@1224|Proteobacteria,2TTEA@28211|Alphaproteobacteria,43KKW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria N Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly - - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA YYD3_k127_5550996_14 1303518.CCALI_02080 3.52e-24 110.0 COG2063@1|root,COG2063@2|Bacteria 2|Bacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K01991,ko:K02393 ko02026,ko02040,map02026,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.B.18 - - FlgH YYD3_k127_5550996_8 1191523.MROS_2159 1.4e-76 267.0 COG1706@1|root,COG1706@2|Bacteria 2|Bacteria N bacterial-type flagellum-dependent cell motility flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI YYD3_k127_5577656_2 94624.Bpet1873 6.298e-46 171.0 COG3153@1|root,COG3153@2|Bacteria,1QTXW@1224|Proteobacteria,2WGH8@28216|Betaproteobacteria 28216|Betaproteobacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 YYD3_k127_5577656_0 118163.Ple7327_3015 9.759e-148 479.0 COG2081@1|root,COG2081@2|Bacteria,1FZZ1@1117|Cyanobacteria,3VIXX@52604|Pleurocapsales 1117|Cyanobacteria S flavoprotein, HI0933 family - - - ko:K07007 - - - - ko00000 - - - HI0933_like YYD3_k127_5577656_1 1379698.RBG1_1C00001G0417 2.675e-53 195.0 COG1198@1|root,COG1198@2|Bacteria,2NNQ3@2323|unclassified Bacteria 2|Bacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII YYD3_k127_5580805_5 1121904.ARBP01000001_gene5870 1.075e-20 93.0 COG0697@1|root,COG0697@2|Bacteria,4NGJR@976|Bacteroidetes,47N5J@768503|Cytophagia 976|Bacteroidetes EG EamA-like transporter family - - - - - - - - - - - - EamA YYD3_k127_5580805_3 861299.J421_4544 1.588e-44 169.0 COG0697@1|root,COG0697@2|Bacteria,1ZTM7@142182|Gemmatimonadetes 142182|Gemmatimonadetes EG EamA-like transporter family - - - - - - - - - - - - EamA YYD3_k127_5580805_2 386043.lwe1848 1.53e-46 189.0 COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,4H9UF@91061|Bacilli,26JFC@186820|Listeriaceae 91061|Bacilli K Fibronectin-binding protein A N-terminus (FbpA) FbpA - - - - - - - - - - - DUF814,FbpA YYD3_k127_5580805_4 573370.DMR_17720 6.033e-22 101.0 COG3585@1|root,COG3585@2|Bacteria,1P6UA@1224|Proteobacteria,432HS@68525|delta/epsilon subdivisions,2WXFT@28221|Deltaproteobacteria,2MFR4@213115|Desulfovibrionales 28221|Deltaproteobacteria H TOBE domain - - - - - - - - - - - - TOBE YYD3_k127_5580805_0 945713.IALB_1750 1.221e-119 416.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD3_k127_5580805_1 1303518.CCALI_00380 6.484e-101 344.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF YYD3_k127_5580805_6 351348.Maqu_3357 0.0001944 45.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,466V2@72275|Alteromonadaceae 1236|Gammaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N YYD3_k127_5604383_4 1292035.H476_3569 8.845e-36 151.0 COG3227@1|root,COG4886@1|root,COG3227@2|Bacteria,COG4886@2|Bacteria,1V3UH@1239|Firmicutes,24K2H@186801|Clostridia,25TYN@186804|Peptostreptococcaceae 186801|Clostridia E Leucine Rich repeats (2 copies) - - - - - - - - - - - - DUF3888,FIVAR,LRR_4 YYD3_k127_5604383_2 42256.RradSPS_2733 1.336e-68 247.0 COG1600@1|root,COG1600@2|Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16,HEAT,HEAT_2 YYD3_k127_5604383_5 909663.KI867151_gene2963 2.056e-08 62.0 COG2204@1|root,COG2204@2|Bacteria,1Q5EK@1224|Proteobacteria,433QZ@68525|delta/epsilon subdivisions,2WXYI@28221|Deltaproteobacteria 2|Bacteria T cheY-homologous receiver domain - - 2.1.1.80,3.1.1.61,3.1.3.3 ko:K03413,ko:K07315,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021 - - - HATPase_c,HDOD,HD_5,Response_reg YYD3_k127_5604383_3 909663.KI867151_gene2964 2.728e-57 203.0 COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,43DNM@68525|delta/epsilon subdivisions,2X6M5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K05586 ko00190,ko01100,map00190,map01100 - R11945 RC00061 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx YYD3_k127_5604383_1 909663.KI867151_gene2965 4.94e-264 824.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MR61@213462|Syntrophobacterales 28221|Deltaproteobacteria C NADH ubiquinone oxidoreductase, NADH-binding - - 1.12.1.3,1.6.5.3 ko:K00124,ko:K00335,ko:K18331 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB YYD3_k127_5604383_0 909663.KI867151_gene2966 0.0 1064.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1NT36@1224|Proteobacteria,42ZEC@68525|delta/epsilon subdivisions,2WU3Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 YYD3_k127_5608423_1 945713.IALB_3128 2.168e-16 92.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - - - - - - - - - - - SGL YYD3_k127_5608423_0 263358.VAB18032_25000 1.886e-27 121.0 COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4DF59@85008|Micromonosporales 201174|Actinobacteria K Belongs to the sigma-70 factor family - - - - - - - - - - - - Sigma70_r2 YYD3_k127_566754_9 1123392.AQWL01000003_gene137 7.479e-19 91.0 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,2VUAP@28216|Betaproteobacteria 28216|Betaproteobacteria P Rieske-like [2Fe-2S] domain - - - ko:K05710,ko:K18087 ko00360,ko00621,ko01100,ko01120,ko01220,map00360,map00621,map01100,map01120,map01220 M00543,M00545 R05261,R05262,R05263,R05264,R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske,Rieske_2 YYD3_k127_566754_3 926554.KI912639_gene1730 3.387e-63 233.0 COG0719@1|root,COG0719@2|Bacteria,1WJ1E@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O TIGRFAM FeS assembly protein SufD - - - ko:K09015 - - - - ko00000 - - - UPF0051 YYD3_k127_566754_0 1379698.RBG1_1C00001G0736 9.267e-231 721.0 COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria 2|Bacteria O FeS assembly protein SufB sufB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - ko:K07033,ko:K09014 - - - - ko00000 - - - UPF0051 YYD3_k127_566754_2 1379698.RBG1_1C00001G0735 2.334e-96 321.0 COG0396@1|root,COG0396@2|Bacteria,2NNYE@2323|unclassified Bacteria 2|Bacteria O ABC transporter sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran YYD3_k127_566754_7 1267535.KB906767_gene4689 1.791e-29 124.0 COG1959@1|root,COG1959@2|Bacteria 2|Bacteria K 2 iron, 2 sulfur cluster binding - - - - - - - - - - - - Rrf2 YYD3_k127_566754_5 338963.Pcar_2070 4.131e-43 165.0 COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,43THX@69541|Desulfuromonadales 28221|Deltaproteobacteria P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp YYD3_k127_566754_1 926550.CLDAP_31550 5.861e-135 450.0 COG4579@1|root,COG4579@2|Bacteria 2|Bacteria F [isocitrate dehydrogenase (NADP+)] phosphatase activity aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK YYD3_k127_566754_6 331869.BAL199_01834 9.146e-30 121.0 2A0NG@1|root,32XDJ@2|Bacteria,1N3J7@1224|Proteobacteria,2UD9K@28211|Alphaproteobacteria,4BSDS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_566754_8 1089551.KE386572_gene4189 4.05e-26 112.0 2A0NG@1|root,32XDJ@2|Bacteria,1N3J7@1224|Proteobacteria,2UD9K@28211|Alphaproteobacteria,4BSDS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_566754_10 1408473.JHXO01000009_gene3379 3.93e-12 74.0 2BXUX@1|root,32R23@2|Bacteria,4NR4Y@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_566754_4 457570.Nther_1950 1.809e-51 187.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia 186801|Clostridia F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like YYD3_k127_5674393_4 379066.GAU_0150 2.496e-13 78.0 2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl YYD3_k127_5674393_5 379066.GAU_0150 9.817e-12 73.0 2FK3G@1|root,34BRK@2|Bacteria,1ZU1V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl YYD3_k127_5674393_0 1379698.RBG1_1C00001G1459 8.491e-161 515.0 COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria 2|Bacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N YYD3_k127_5674393_2 1231057.AMGD01000013_gene1540 5.302e-117 383.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,26DE6@186818|Planococcaceae 91061|Bacilli I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain mmgB - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N YYD3_k127_5674393_1 1379698.RBG1_1C00001G1458 1.345e-132 432.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N YYD3_k127_5674393_3 1379698.RBG1_1C00001G1457 3.126e-116 386.0 COG1960@1|root,COG1960@2|Bacteria,2NNRN@2323|unclassified Bacteria 2|Bacteria I Dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N YYD3_k127_5674393_6 111781.Lepto7376_0500 1.509e-06 57.0 COG1943@1|root,COG1943@2|Bacteria,1G5Y7@1117|Cyanobacteria,1HCR7@1150|Oscillatoriales 1117|Cyanobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp YYD3_k127_5676619_4 1379698.RBG1_1C00001G0474 1.415e-106 354.0 COG0617@1|root,COG0617@2|Bacteria,2NPB4@2323|unclassified Bacteria 2|Bacteria J Poly A polymerase head domain cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 YYD3_k127_5676619_3 1379698.RBG1_1C00001G0473 4.912e-117 386.0 COG0549@1|root,COG0549@2|Bacteria,2NNKM@2323|unclassified Bacteria 2|Bacteria E Amino acid kinase family arcC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_3652,iE2348C_1286.E2348C_0454,iECABU_c1320.ECABU_c31550,iECED1_1282.ECED1_0540,iECED1_1282.ECED1_3334,iECIAI39_1322.ECIAI39_3289,iECNA114_1301.ECNA114_2915,iECOK1_1307.ECOK1_3260,iECS88_1305.ECS88_3153,iECSF_1327.ECSF_2670,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iHN637.CLJU_RS13830,iJN746.PP_0999,iUMN146_1321.UM146_02150,iUTI89_1310.UTI89_C3259,ic_1306.c3452 AA_kinase YYD3_k127_5676619_1 880073.Calab_0633 1.289e-202 642.0 COG2403@1|root,COG2403@2|Bacteria,2NNTB@2323|unclassified Bacteria 2|Bacteria S cyclic 2,3-diphosphoglycerate synthetase activity cpgS - - ko:K05716 - - R03298 RC00900 ko00000,ko01000 - - - cobW YYD3_k127_5676619_0 1379698.RBG1_1C00001G0471 5.506e-219 689.0 COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria 2|Bacteria C Belongs to the aldehyde dehydrogenase family ycbD - 1.2.1.3 ko:K00128,ko:K22187 ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh YYD3_k127_5676619_5 344747.PM8797T_06170 8.388e-42 162.0 COG0122@1|root,COG0122@2|Bacteria,2J036@203682|Planctomycetes 203682|Planctomycetes L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase - - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD YYD3_k127_5676619_2 1313304.CALK_1921 7.187e-120 397.0 COG0343@1|root,COG0343@2|Bacteria 2|Bacteria F queuine tRNA-ribosyltransferase activity tgt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT YYD3_k127_5691434_2 880073.Calab_2347 7.588e-41 158.0 COG2386@1|root,COG2386@2|Bacteria,2NPHG@2323|unclassified Bacteria 2|Bacteria O CcmB protein ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193,ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iECO111_1330.ECO111_2936,iYL1228.KPN_02080 CcmB YYD3_k127_5691434_1 880073.Calab_2346 1.414e-44 169.0 COG1131@1|root,COG1131@2|Bacteria,2NPQ3@2323|unclassified Bacteria 2|Bacteria V ATPases associated with a variety of cellular activities ccmA - 3.6.3.41 ko:K01990,ko:K02193 ko02010,map02010 M00254,M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.107 - - ABC_tran YYD3_k127_5691434_0 1379698.RBG1_1C00001G0425 6.511e-73 254.0 COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria 2|Bacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 YYD3_k127_5691434_3 1379698.RBG1_1C00001G0410 4.191e-36 142.0 COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria 2|Bacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 YYD3_k127_5734722_2 1032480.MLP_33800 2.638e-16 91.0 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding - - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 YYD3_k127_5734722_1 665959.HMPREF1013_04214 4.387e-47 174.0 COG2318@1|root,COG2318@2|Bacteria,1V6MV@1239|Firmicutes,4HH68@91061|Bacilli,1ZFX8@1386|Bacillus 91061|Bacilli S DinB superfamily - - - - - - - - - - - - DinB_2 YYD3_k127_5734722_0 1379698.RBG1_1C00001G0616 4.116e-108 363.0 COG4412@1|root,COG4412@2|Bacteria 2|Bacteria S peptidase activity, acting on L-amino acid peptides - - - - - - - - - - - - F5_F8_type_C,Peptidase_M6 YYD3_k127_5734757_1 1191523.MROS_0285 6.384e-128 444.0 2E09V@1|root,32VXB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_5734757_0 880073.Calab_2072 2.635e-138 476.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec YYD3_k127_5734757_4 880073.Calab_0077 2.639e-20 99.0 COG0558@1|root,COG0558@2|Bacteria,2NQ32@2323|unclassified Bacteria 2|Bacteria I CDP-alcohol phosphatidyltransferase pgsA GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf YYD3_k127_5734757_2 1449126.JQKL01000038_gene965 4.209e-90 310.0 COG3616@1|root,COG3616@2|Bacteria,1TSES@1239|Firmicutes,24A0X@186801|Clostridia 186801|Clostridia E PFAM Alanine racemase - - - - - - - - - - - - Ala_racemase_N,D-ser_dehydrat YYD3_k127_5734757_7 1158146.KB907121_gene1092 0.0004421 53.0 COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,1S4SH@1236|Gammaproteobacteria,1WZF6@135613|Chromatiales 135613|Chromatiales MU Outer membrane efflux protein - - - - - - - - - - - - OEP YYD3_k127_5734757_6 1134510.O9A_00247 0.0001464 55.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,48TB8@772|Bartonellaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind YYD3_k127_5734757_5 1101191.KI912577_gene2342 1.139e-17 87.0 COG0784@1|root,COG3920@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG3920@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JQUH@119045|Methylobacteriaceae 28211|Alphaproteobacteria T histidine kinase A domain protein - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,dCache_1 YYD3_k127_5734757_3 880073.Calab_1578 2.45e-23 107.0 COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria 2|Bacteria V ABC transporter MdlB - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran YYD3_k127_5735211_5 700598.Niako_7016 0.0003688 44.0 COG4758@1|root,COG4758@2|Bacteria,4NQRE@976|Bacteroidetes,1ISAD@117747|Sphingobacteriia 976|Bacteroidetes S membrane protein (DUF2154) - - - - - - - - - - - - DUF2154 YYD3_k127_5735211_2 1198452.Jab_1c25300 4.886e-33 136.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2W9CU@28216|Betaproteobacteria,4769K@75682|Oxalobacteraceae 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - His_kinase YYD3_k127_5735211_1 1379698.RBG1_1C00001G1850 5.92e-64 229.0 COG0705@1|root,COG0705@2|Bacteria,2NPSK@2323|unclassified Bacteria 2|Bacteria S Rhomboid family - - - - - - - - - - - - Rhomboid YYD3_k127_5735211_3 1379698.RBG1_1C00001G1851 3.233e-13 81.0 COG3437@1|root,COG3437@2|Bacteria 2|Bacteria T response regulator, receiver - - 2.7.13.3 ko:K03407,ko:K07648,ko:K07679,ko:K11356 ko02020,ko02026,ko02030,ko05133,map02020,map02026,map02030,map05133 M00456,M00477,M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HTH_18,HisKA,Hpt,PAS_3,PAS_4,PAS_7,Reg_prop,Response_reg,Y_Y_Y YYD3_k127_5735211_0 1379698.RBG1_1C00001G1619 1.17e-70 247.0 COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria 2|Bacteria O Cytochrome C biogenesis protein transmembrane region ccdA - 1.8.4.11,1.8.4.12 ko:K06196,ko:K12267 - - - - ko00000,ko01000,ko02000 5.A.1.2 - - AhpC-TSA,DsbD YYD3_k127_5735211_4 1121904.ARBP01000001_gene5581 3.176e-11 73.0 COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,47PF2@768503|Cytophagia 976|Bacteroidetes S protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 YYD3_k127_5737617_1 945713.IALB_0720 2.777e-188 607.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria 2|Bacteria P mercury ion transmembrane transporter activity fixI GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase YYD3_k127_5737617_2 1191523.MROS_1512 8.461e-13 70.0 COG3197@1|root,COG3197@2|Bacteria 2|Bacteria P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS YYD3_k127_5737617_0 1191523.MROS_1513 6.621e-257 799.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor ccoO GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404,ko:K00405,ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - iIT341.HP0144,iIT341.HP0145 COX1,FixO YYD3_k127_5808918_0 1444309.JAQG01000021_gene1409 6.859e-67 240.0 COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,4HADV@91061|Bacilli,26SSK@186822|Paenibacillaceae 91061|Bacilli J Related to alanyl-tRNA synthetase HxxxH domain alaS_2 - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD YYD3_k127_5808918_1 1033743.CAES01000101_gene3607 5.248e-35 153.0 COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,4HDA6@91061|Bacilli,275PA@186822|Paenibacillaceae 91061|Bacilli E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 YYD3_k127_5808918_2 1048339.KB913029_gene3470 1.536e-27 113.0 COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4ERX7@85013|Frankiales 201174|Actinobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase fahA - - - - - - - - - - - DUF2437,FAA_hydrolase YYD3_k127_5833420_0 1191523.MROS_2800 9.31e-203 635.0 COG0334@1|root,COG0334@2|Bacteria 2|Bacteria E glutamate dehydrogenase [NAD(P)+] activity gluD GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.gdhA ELFV_dehydrog,ELFV_dehydrog_N YYD3_k127_5833420_1 861299.J421_1428 1.771e-05 48.0 COG1524@1|root,COG1524@2|Bacteria,1ZTCS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest YYD3_k127_5837269_2 246194.CHY_1102 2.201e-147 482.0 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,42EXF@68295|Thermoanaerobacterales 186801|Clostridia J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase YYD3_k127_5837269_5 526227.Mesil_2652 7.173e-37 149.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity bioH - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 YYD3_k127_5837269_6 903818.KI912268_gene2872 1.34e-20 100.0 COG1011@1|root,COG1011@2|Bacteria,3Y56D@57723|Acidobacteria 57723|Acidobacteria S HAD-superfamily hydrolase, subfamily IA, variant 3 - - - ko:K07025 - - - - ko00000 - - - HAD_2 YYD3_k127_5837269_0 1304885.AUEY01000058_gene2321 1.898e-167 539.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MIIZ@213118|Desulfobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey YYD3_k127_5837269_4 518766.Rmar_1872 1.046e-52 195.0 COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1FITI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N YYD3_k127_5837269_3 1379698.RBG1_1C00001G0971 4.611e-113 372.0 COG0152@1|root,COG0152@2|Bacteria,2NP0V@2323|unclassified Bacteria 2|Bacteria F SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 - - - SAICAR_synt YYD3_k127_5837269_1 1385511.N783_07320 8.324e-152 495.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli,2Y9WM@289201|Pontibacillus 91061|Bacilli F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS YYD3_k127_5863191_0 448385.sce7786 8.553e-159 516.0 COG3104@1|root,COG3104@2|Bacteria,1P6K2@1224|Proteobacteria 1224|Proteobacteria E PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 YYD3_k127_5863191_1 272952.HpaP806918 2.279e-87 301.0 COG0042@1|root,KOG2335@2759|Eukaryota,3QEGX@4776|Peronosporales 4776|Peronosporales J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs - - - - - - - - - - - - Dus YYD3_k127_5863191_2 877455.Metbo_2475 2.576e-68 246.0 COG3291@1|root,arCOG02516@1|root,arCOG09475@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02516@2157|Archaea,arCOG09475@2157|Archaea,2Y7U0@28890|Euryarchaeota 28890|Euryarchaeota S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - PKD YYD3_k127_5864212_0 1379698.RBG1_1C00001G1233 6.753e-164 535.0 COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria 2|Bacteria M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 YYD3_k127_5864212_1 234267.Acid_5940 2.729e-139 456.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase YYD3_k127_5867507_3 1117108.PAALTS15_09559 1.192e-29 121.0 COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,26R2I@186822|Paenibacillaceae 91061|Bacilli S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N YYD3_k127_5867507_0 945713.IALB_2371 6.866e-262 818.0 COG0481@1|root,COG0481@2|Bacteria 2|Bacteria M GTPase activity lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C YYD3_k127_5867507_1 580340.Tlie_1509 2.09e-49 182.0 COG2077@1|root,COG2077@2|Bacteria,3TAX1@508458|Synergistetes 508458|Synergistetes O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin YYD3_k127_5867507_2 530564.Psta_0541 6.598e-45 168.0 COG0590@1|root,COG0590@2|Bacteria,2IZCA@203682|Planctomycetes 203682|Planctomycetes FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam YYD3_k127_5875176_2 1047013.AQSP01000134_gene1374 1.651e-32 132.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux YYD3_k127_5875176_1 1047013.AQSP01000134_gene1374 1.588e-70 256.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - - - - ko:K01992,ko:K16919 ko02010,map02010 M00254,M00584 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4,ABC_transp_aux YYD3_k127_5875176_0 1047013.AQSP01000134_gene1373 4.305e-93 311.0 COG1131@1|root,COG1131@2|Bacteria,2NR18@2323|unclassified Bacteria 2|Bacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran YYD3_k127_5875176_3 679926.Mpet_0862 3.338e-06 58.0 COG1470@1|root,arCOG02087@2157|Archaea,2XW1B@28890|Euryarchaeota,2NBNC@224756|Methanomicrobia 28890|Euryarchaeota S PFAM NPCBM-associated, NEW3 domain of alpha-galactosidase - - - - - - - - - - - - CarboxypepD_reg,NPCBM_assoc YYD3_k127_5877995_6 1379698.RBG1_1C00001G0825 1.419e-08 66.0 28P4Q@1|root,2ZBZV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_5877995_5 1121930.AQXG01000003_gene2491 2.001e-12 78.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - PSCyt1 YYD3_k127_5877995_3 1288963.ADIS_3055 1.383e-14 83.0 COG2353@1|root,COG2353@2|Bacteria 2|Bacteria O YceI-like domain - - - - - - - - - - - - YceI YYD3_k127_5877995_4 880073.Calab_0883 4.622e-13 75.0 COG2922@1|root,COG2922@2|Bacteria 2|Bacteria S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 YYD3_k127_5877995_1 1196029.ALIM01000014_gene3236 1.365e-109 368.0 COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4HAK8@91061|Bacilli,1ZD3R@1386|Bacillus 91061|Bacilli H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein YYD3_k127_5877995_2 1379698.RBG1_1C00001G0976 2.337e-67 239.0 COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria 2|Bacteria L Uracil DNA glycosylase superfamily ung - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG YYD3_k127_5877995_0 56780.SYN_00640 8.381e-118 392.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MQ50@213462|Syntrophobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C YYD3_k127_5894795_1 349741.Amuc_1222 4.732e-85 288.0 COG1297@1|root,COG1297@2|Bacteria,46TNW@74201|Verrucomicrobia,2IV9P@203494|Verrucomicrobiae 203494|Verrucomicrobiae S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT YYD3_k127_5894795_4 1122939.ATUD01000002_gene1305 1.455e-41 161.0 COG3000@1|root,COG3000@2|Bacteria,2ISSM@201174|Actinobacteria,4CQ11@84995|Rubrobacteria 84995|Rubrobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase YYD3_k127_5894795_0 1408473.JHXO01000006_gene1092 4.603e-93 312.0 COG0388@1|root,COG0388@2|Bacteria,4PPAR@976|Bacteroidetes,2G14Y@200643|Bacteroidia 976|Bacteroidetes S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase YYD3_k127_5894795_5 207559.Dde_3099 2.84e-30 124.0 COG3695@1|root,COG3695@2|Bacteria,1PZ1K@1224|Proteobacteria,42WV5@68525|delta/epsilon subdivisions,2WT08@28221|Deltaproteobacteria,2MGUT@213115|Desulfovibrionales 28221|Deltaproteobacteria L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 YYD3_k127_5894795_3 1430331.EP10_15180 2.561e-44 172.0 COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,4HDIE@91061|Bacilli,1WF9J@129337|Geobacillus 91061|Bacilli EG EamA-like transporter family - - - - - - - - - - - - EamA YYD3_k127_592838_1 118005.AWNK01000006_gene1183 2.803e-44 166.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg YYD3_k127_592838_3 1191523.MROS_2120 6.033e-35 140.0 COG0745@1|root,COG0745@2|Bacteria 1191523.MROS_2120|- T phosphorelay signal transduction system - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - - YYD3_k127_592838_0 882.DVU_2076 4.688e-85 292.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QJT@68525|delta/epsilon subdivisions,2WJ1S@28221|Deltaproteobacteria,2M8MF@213115|Desulfovibrionales 28221|Deltaproteobacteria NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N YYD3_k127_592838_4 639282.DEFDS_1712 7.7e-29 120.0 COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,2GETM@200930|Deferribacteres 200930|Deferribacteres T HD domain - - - - - - - - - - - - HD_5,Response_reg YYD3_k127_592838_2 243231.GSU2216 6.872e-38 162.0 COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WPWV@28221|Deltaproteobacteria,43UH8@69541|Desulfuromonadales 28221|Deltaproteobacteria C HEAT repeat - - - - - - - - - - - - HEAT,HEAT_2,HEAT_PBS YYD3_k127_592838_6 313612.L8106_20448 2.736e-13 74.0 COG1366@1|root,COG1366@2|Bacteria,1GA96@1117|Cyanobacteria,1HD2N@1150|Oscillatoriales 1117|Cyanobacteria T Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) - - - - - - - - - - - - STAS,STAS_2 YYD3_k127_592838_7 931276.Cspa_c50680 0.0001036 50.0 COG2172@1|root,COG2172@2|Bacteria,1VMMN@1239|Firmicutes,25MYN@186801|Clostridia,36KVF@31979|Clostridiaceae 186801|Clostridia T Histidine kinase-like ATPase domain - - 2.7.11.1 ko:K04757 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c_2 YYD3_k127_592838_5 479437.Elen_2938 1.14e-25 113.0 COG2208@1|root,COG2208@2|Bacteria,2I9FT@201174|Actinobacteria,4CWAU@84998|Coriobacteriia 84998|Coriobacteriia KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE YYD3_k127_5929936_5 1125863.JAFN01000001_gene1954 2.556e-16 93.0 COG0745@1|root,COG2804@1|root,COG0745@2|Bacteria,COG2804@2|Bacteria 2|Bacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE_N YYD3_k127_5929936_6 1125863.JAFN01000001_gene2246 0.0001416 44.0 COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C YYD3_k127_5929936_2 264732.Moth_1625 9.133e-94 315.0 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,42ENJ@68295|Thermoanaerobacterales 186801|Clostridia F Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C YYD3_k127_5929936_1 1379698.RBG1_1C00001G0818 4.817e-94 312.0 COG0605@1|root,COG0605@2|Bacteria,2NP62@2323|unclassified Bacteria 2|Bacteria P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010269,GO:0010447,GO:0016020,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0020012,GO:0030145,GO:0030682,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052059,GO:0052173,GO:0052200,GO:0052385,GO:0052550,GO:0052564,GO:0052567,GO:0052572,GO:0055114,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071291,GO:0071450,GO:0071451,GO:0071944,GO:0072593,GO:0075136,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 ko:K03601,ko:K04564 ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000,ko03400 - - iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iE2348C_1286.E2348C_4213,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSF_1327.ECSF_3769,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNJ661.Rv3846,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050 Sod_Fe_C,Sod_Fe_N YYD3_k127_5929936_0 1379698.RBG1_1C00001G0297 5.627e-159 511.0 COG4881@1|root,COG4881@2|Bacteria 2|Bacteria - - cbcU - - - - - - - - - - - NrfD YYD3_k127_5929936_3 1379698.RBG1_1C00001G0296 2.905e-87 300.0 COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria 2|Bacteria C 4Fe-4S binding domain ttrB - - ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 - R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 - - Fer4_11,Fer4_3,Fer4_7 YYD3_k127_5929936_4 1379698.RBG1_1C00001G0295 2.895e-64 228.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - ko:K04013,ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 - - - Cytochrom_C552,Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1 YYD3_k127_5987066_2 159087.Daro_2102 4.441e-30 120.0 COG0811@1|root,COG0811@2|Bacteria,1QVBX@1224|Proteobacteria,2WGPD@28216|Betaproteobacteria,2KV1P@206389|Rhodocyclales 206389|Rhodocyclales U Domain of unknown function (DUF802) - - - - - - - - - - - - DUF802 YYD3_k127_5987066_0 1519464.HY22_13955 1.113e-153 499.0 COG1239@1|root,COG1239@2|Bacteria,1FF03@1090|Chlorobi 1090|Chlorobi H Sigma-54 interaction domain - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - Sigma54_activat YYD3_k127_5987066_3 575605.ACQN01000026_gene849 2.853e-11 67.0 COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,4HKJJ@91061|Bacilli,3F7JX@33958|Lactobacillaceae 91061|Bacilli J S4 domain protein yabO - - - - - - - - - - - S4 YYD3_k127_5987066_1 1379698.RBG1_1C00001G0705 4.272e-97 331.0 COG0760@1|root,COG0760@2|Bacteria,2NPFB@2323|unclassified Bacteria 2|Bacteria O PPIC-type PPIASE domain surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N_3 YYD3_k127_5994630_2 1386089.N865_08815 2.263e-11 77.0 COG1404@1|root,COG1404@2|Bacteria,2GIRE@201174|Actinobacteria,4FGR4@85021|Intrasporangiaceae 201174|Actinobacteria O Subtilase family mycP - - ko:K14743 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 YYD3_k127_5994630_0 945713.IALB_0188 1.953e-24 120.0 COG1649@1|root,COG4733@1|root,COG1649@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity J - 3.2.1.11,3.2.1.18,3.2.1.35 ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K21449 ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142 M00076,M00077 R04018,R07824,R07825,R10905,R11309 RC00028,RC00077 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02000,ko02042 1.B.40.2 GH33,GH66 - DUF1983,DUF3672,Phage-tail_3 YYD3_k127_5994630_1 706587.Desti_4846 1.024e-20 102.0 2DRBJ@1|root,32UQT@2|Bacteria,1NZ28@1224|Proteobacteria,430B9@68525|delta/epsilon subdivisions,2WVZQ@28221|Deltaproteobacteria,2MRY8@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_600576_1 1379698.RBG1_1C00001G0531 5.144e-42 163.0 COG0451@1|root,COG0451@2|Bacteria,2NPC7@2323|unclassified Bacteria 2|Bacteria GM NAD(P)H-binding JD73_00815 - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase YYD3_k127_600576_0 1379698.RBG1_1C00001G0529 4.325e-56 204.0 COG0520@1|root,COG0520@2|Bacteria,2NP4B@2323|unclassified Bacteria 2|Bacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_5 YYD3_k127_6035342_3 944480.ATUV01000001_gene1244 2.922e-23 100.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2M6HD@213113|Desulfurellales 28221|Deltaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small YYD3_k127_6035342_0 1379698.RBG1_1C00001G1453 9.325e-191 604.0 COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria 2|Bacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - iG2583_1286.G2583_3081,iIT341.HP0183 SHMT YYD3_k127_6035342_4 1379698.RBG1_1C00001G1452 6.712e-22 98.0 COG0011@1|root,COG0011@2|Bacteria 2|Bacteria H TIGRFAM Protein of - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Thiamine_BP YYD3_k127_6035342_2 638303.Thal_0887 9.198e-27 112.0 COG1324@1|root,COG1324@2|Bacteria,2G58I@200783|Aquificae 200783|Aquificae P CutA1 divalent ion tolerance protein cutA - - ko:K03926 - - - - ko00000 - - - CutA1 YYD3_k127_6035342_1 1379698.RBG1_1C00001G1448 5.577e-55 196.0 COG1327@1|root,COG1327@2|Bacteria,2NPEU@2323|unclassified Bacteria 2|Bacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone YYD3_k127_6035342_5 880073.Calab_0966 8.313e-16 82.0 COG0805@1|root,COG0805@2|Bacteria,2NPGB@2323|unclassified Bacteria 2|Bacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC YYD3_k127_6050913_8 404380.Gbem_0043 2.853e-38 157.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions,2WJUK@28221|Deltaproteobacteria,43S0R@69541|Desulfuromonadales 28221|Deltaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxA - 1.10.3.10,1.9.3.1 ko:K02274,ko:K02298 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6 - - COX1 YYD3_k127_6050913_3 411154.GFO_1406 1.496e-62 227.0 COG1277@1|root,COG1277@2|Bacteria,4NGGR@976|Bacteroidetes,1HXF5@117743|Flavobacteriia 976|Bacteroidetes S nitrous oxide - - - ko:K19341 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC2_membrane_2,ABC2_membrane_5 YYD3_k127_6050913_2 746697.Aeqsu_0138 1.538e-65 231.0 COG1131@1|root,COG1131@2|Bacteria,4NG9T@976|Bacteroidetes,1HYYD@117743|Flavobacteriia 976|Bacteroidetes V ABC-type multidrug transport system ATPase component - - - ko:K19340 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC_tran YYD3_k127_6050913_1 1191523.MROS_1106 5.87e-118 392.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process nosD - - ko:K07218 - - - - ko00000 - - - NosD YYD3_k127_6050913_9 1191523.MROS_1105 3.555e-30 124.0 COG4314@1|root,COG4314@2|Bacteria 2|Bacteria C lipoprotein involved in nitrous oxide reduction nosL - - ko:K19342 - - - - ko00000 - - - NosL YYD3_k127_6050913_4 123214.PERMA_1258 1.482e-56 205.0 COG4314@1|root,COG4314@2|Bacteria,2G4TU@200783|Aquificae 200783|Aquificae C lipoprotein involved in nitrous oxide reduction - - - - - - - - - - - - - YYD3_k127_6050913_0 1191523.MROS_1104 0.0 1005.0 COG4263@1|root,COG4263@2|Bacteria 2|Bacteria C nitrous-oxide reductase activity nosZ GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234 1.7.2.4,1.9.3.1 ko:K00376,ko:K02275 ko00190,ko00910,ko01100,ko01120,map00190,map00910,map01100,map01120 M00155,M00529 R00081,R02804 RC00016,RC02861 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,Cupredoxin_1 YYD3_k127_6050913_10 1191523.MROS_1103 2.846e-27 117.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cytochrom_C,Cytochrome_CBB3 YYD3_k127_6050913_7 1121930.AQXG01000001_gene1021 4.844e-39 149.0 COG1959@1|root,COG1959@2|Bacteria,4NURI@976|Bacteroidetes 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - Rrf2 YYD3_k127_6050913_6 1366050.N234_03595 1.694e-46 179.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria,1K07H@119060|Burkholderiaceae 28216|Betaproteobacteria NU Type II secretion system tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF YYD3_k127_6050913_5 296591.Bpro_2556 7.711e-51 192.0 COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,4A9JG@80864|Comamonadaceae 28216|Betaproteobacteria U Type II secretion system - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF YYD3_k127_6053900_1 945713.IALB_1647 2.592e-21 100.0 28KE7@1|root,2ZA0G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_6053900_0 648757.Rvan_1397 1.437e-168 548.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria 1224|Proteobacteria S oligopeptide transporter - - - - - - - - - - - - OPT YYD3_k127_607122_3 644966.Tmar_1747 2.131e-18 94.0 COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia 1239|Firmicutes C FAD linked oxidases, C-terminal domain - - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 YYD3_k127_607122_1 1137799.GZ78_14000 9.124e-74 257.0 COG0500@1|root,COG2226@2|Bacteria,1R6ZI@1224|Proteobacteria,1SYW2@1236|Gammaproteobacteria,1XK75@135619|Oceanospirillales 135619|Oceanospirillales Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_11 YYD3_k127_607122_4 1379698.RBG1_1C00001G0198 1.544e-17 96.0 COG2885@1|root,COG5276@1|root,COG2885@2|Bacteria,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - - - - - - - - - - - Phenol_MetA_deg YYD3_k127_607122_0 1191523.MROS_2693 1.755e-260 811.0 COG0459@1|root,COG0459@2|Bacteria 2|Bacteria O protein refolding groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016465,GO:0018995,GO:0020003,GO:0023051,GO:0023056,GO:0030430,GO:0032991,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0051082,GO:0061077,GO:0065007,GO:0065010,GO:0101031,GO:1901222,GO:1901224,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 YYD3_k127_607122_2 1379698.RBG1_1C00001G0288 6.12e-43 158.0 COG0234@1|root,COG0234@2|Bacteria,2NPW2@2323|unclassified Bacteria 2|Bacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 YYD3_k127_6094961_0 1121472.AQWN01000007_gene1136 1.732e-117 386.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24DPN@186801|Clostridia,260G2@186807|Peptococcaceae 186801|Clostridia I TIGRFAM Acetoacetyl-CoA synthase - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C YYD3_k127_6094961_1 945713.IALB_1670 6.941e-86 291.0 COG1853@1|root,COG1853@2|Bacteria 2|Bacteria S FMN binding - - - - - - - - - - - - Flavin_Reduct YYD3_k127_6133362_3 1379698.RBG1_1C00001G1403 7.322e-13 73.0 COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria 2|Bacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_2,GSDH YYD3_k127_6133362_1 948106.AWZT01000001_gene5337 2.232e-57 212.0 COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,2VTKP@28216|Betaproteobacteria,1K3AS@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM OsmC family protein osmC - - ko:K04063 - - - - ko00000 - - - OsmC YYD3_k127_6133362_0 246194.CHY_0588 1.869e-83 294.0 COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,42F15@68295|Thermoanaerobacterales 186801|Clostridia P PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr YYD3_k127_6133362_2 1121422.AUMW01000024_gene240 4.134e-30 128.0 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,262RV@186807|Peptococcaceae 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily algU - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD3_k127_6133362_4 189753.AXAS01000023_gene826 5.37e-05 52.0 COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,3JRXS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Putative zinc-finger - - - - - - - - - - - - zf-HC2 YYD3_k127_6146607_2 755731.Clo1100_1628 2.68e-05 53.0 2DYSE@1|root,34AX4@2|Bacteria,1VYJA@1239|Firmicutes,24X6H@186801|Clostridia 186801|Clostridia S Helix-turn-helix domain - - - - - - - - - - - - HTH_17 YYD3_k127_6146607_1 1201290.M902_0770 6.713e-14 79.0 COG0640@1|root,COG3860@1|root,COG0640@2|Bacteria,COG3860@2|Bacteria,1N3KK@1224|Proteobacteria,42TH7@68525|delta/epsilon subdivisions,2WQ6A@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Uncharacterized protein conserved in bacteria (DUF2087) - - - - - - - - - - - - DUF2087,GIY-YIG,HTH_20 YYD3_k127_6146607_0 1379698.RBG1_1C00001G0356 6.733e-112 381.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,2NS3S@2323|unclassified Bacteria 2|Bacteria EG Protein of unknown function (DUF2723) - - - ko:K16928 - M00582 - - ko00000,ko00002,ko02000 3.A.1.33 - - DUF2723,QueT YYD3_k127_6148257_0 1379698.RBG1_1C00001G1230 1.009e-78 270.0 COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria 2|Bacteria J tRNA synthetases class I (W and Y) trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b YYD3_k127_6148257_2 1379698.RBG1_1C00001G1229 9.356e-52 192.0 COG1354@1|root,COG1354@2|Bacteria,2NPM8@2323|unclassified Bacteria 2|Bacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA YYD3_k127_6148257_3 1191523.MROS_2552 8.44e-49 184.0 COG1386@1|root,COG1386@2|Bacteria 2|Bacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB YYD3_k127_6148257_1 1209989.TepiRe1_1463 1.413e-61 220.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales 186801|Clostridia J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 YYD3_k127_6294155_1 984262.SGRA_3562 4.6e-42 173.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1IYS6@117747|Sphingobacteriia 976|Bacteroidetes S cellulase activity - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 YYD3_k127_6294155_0 56780.SYN_01854 2.753e-104 371.0 COG1204@1|root,COG1204@2|Bacteria,1MW4Z@1224|Proteobacteria,42TK8@68525|delta/epsilon subdivisions,2WQUX@28221|Deltaproteobacteria 28221|Deltaproteobacteria L helicase superfamily c-terminal domain - - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,Helicase_C YYD3_k127_6294155_2 448385.sce4504 0.0001259 47.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YX2C@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C YYD3_k127_6299452_3 1123373.ATXI01000009_gene323 3.286e-17 88.0 COG0557@1|root,COG0557@2|Bacteria,2GH2N@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 YYD3_k127_6299452_2 926560.KE387023_gene2874 3.578e-25 109.0 2EM7W@1|root,33EX0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_6299452_1 561180.BIFGAL_03343 4.04e-64 237.0 COG0619@1|root,COG1129@1|root,COG0619@2|Bacteria,COG1129@2|Bacteria,2I2G4@201174|Actinobacteria,4CZJE@85004|Bifidobacteriales 201174|Actinobacteria GP ABC transporter, ATP-binding protein - - - ko:K16785,ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran,CbiQ YYD3_k127_6299452_0 1379698.RBG1_1C00001G1497 1.137e-183 586.0 COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS11880 Aminotran_5,GDC-P YYD3_k127_6319381_2 204669.Acid345_4648 2.195e-11 70.0 COG0745@1|root,COG0745@2|Bacteria,3Y8XM@57723|Acidobacteria 57723|Acidobacteria T Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388,Response_reg YYD3_k127_6319381_1 1379698.RBG1_1C00001G0211 2.132e-39 160.0 COG0457@1|root,COG0457@2|Bacteria,2NQ8S@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - - YYD3_k127_6319381_3 73044.JNXP01000009_gene2806 2.163e-06 59.0 COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria 201174|Actinobacteria K AntiSigma factor rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - - - - - - - - - - zf-HC2 YYD3_k127_6319381_0 1379698.RBG1_1C00001G1618 1.695e-61 218.0 COG1595@1|root,COG1595@2|Bacteria,2NPHU@2323|unclassified Bacteria 2|Bacteria K RNA polymerase sigma factor sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 YYD3_k127_6319381_4 215803.DB30_1296 6.177e-05 53.0 COG2706@1|root,COG2706@2|Bacteria 2|Bacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - FG-GAP,VCBS YYD3_k127_6326160_0 357808.RoseRS_1917 3.101e-109 357.0 COG0798@1|root,COG0798@2|Bacteria,2G5ZH@200795|Chloroflexi,37708@32061|Chloroflexia 32061|Chloroflexia P Sodium Bile acid symporter family - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF YYD3_k127_6326160_3 743722.Sph21_0232 8.83e-43 160.0 COG0394@1|root,COG0394@2|Bacteria,4NNN6@976|Bacteroidetes,1IS9S@117747|Sphingobacteriia 976|Bacteroidetes T Low molecular weight phosphotyrosine protein phosphatase arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc YYD3_k127_6326160_1 573061.Clocel_3666 8.123e-94 318.0 COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,36DDQ@31979|Clostridiaceae 186801|Clostridia C PFAM Radical SAM domain protein - - - ko:K22226 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM YYD3_k127_6326160_2 596329.HMPREF0631_1805 6.726e-53 198.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,24A6D@186801|Clostridia,25REJ@186804|Peptostreptococcaceae 186801|Clostridia C 4Fe-4S single cluster domain - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM YYD3_k127_6334176_0 697284.ERIC2_c36440 1.978e-88 298.0 COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,4HB80@91061|Bacilli,26RUP@186822|Paenibacillaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P YYD3_k127_6334176_2 1123073.KB899241_gene2430 6.639e-07 59.0 COG4232@1|root,COG4232@2|Bacteria,1R2KR@1224|Proteobacteria,1T5SN@1236|Gammaproteobacteria,1XDEM@135614|Xanthomonadales 135614|Xanthomonadales CO Thioredoxin-like - - - - - - - - - - - - Thioredoxin_7 YYD3_k127_6334176_3 1191523.MROS_1631 5.09e-06 53.0 COG2260@1|root,COG2260@2|Bacteria 2|Bacteria J snoRNA binding - - - - - - - - - - - - DUF2007 YYD3_k127_6334176_1 1379698.RBG1_1C00001G1499 8.102e-68 237.0 COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P YYD3_k127_6348466_0 1379698.RBG1_1C00001G1089 7.399e-70 244.0 COG3437@1|root,COG3437@2|Bacteria,2NP8B@2323|unclassified Bacteria 2|Bacteria T metal-dependent phosphohydrolase HD region - - - - - - - - - - - - GAF,GAF_2,GGDEF,HD,HD_5,PAS,PAS_3,PAS_9,Response_reg YYD3_k127_6348466_1 1379698.RBG1_1C00001G1090 1.876e-62 226.0 COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 YYD3_k127_6414725_0 1123267.JONN01000001_gene1238 2.242e-166 546.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP YYD3_k127_6414725_4 1123267.JONN01000001_gene1239 1.311e-41 166.0 2C1YS@1|root,2ZD2Y@2|Bacteria 2|Bacteria S Protease prsW family - - - - - - - - - - - - PrsW-protease YYD3_k127_6414725_5 1121957.ATVL01000008_gene4553 7.941e-25 121.0 COG5295@1|root,COG5295@2|Bacteria,4NKG1@976|Bacteroidetes,47NK6@768503|Cytophagia 976|Bacteroidetes MUW domain, Protein - - - - - - - - - - - - Peptidase_S74 YYD3_k127_6414725_6 1121957.ATVL01000008_gene4553 5.343e-22 112.0 COG5295@1|root,COG5295@2|Bacteria,4NKG1@976|Bacteroidetes,47NK6@768503|Cytophagia 976|Bacteroidetes MUW domain, Protein - - - - - - - - - - - - Peptidase_S74 YYD3_k127_6414725_8 694427.Palpr_0773 6.425e-05 56.0 2ENNG@1|root,33G9U@2|Bacteria,4NZMI@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_6414725_7 1379698.RBG1_1C00001G0237 2.799e-08 67.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,LVIVD YYD3_k127_6414725_1 880073.Calab_0349 1.105e-151 491.0 COG4992@1|root,COG4992@2|Bacteria,2NP0N@2323|unclassified Bacteria 2|Bacteria E acetylornithine and succinylornithine aminotransferase lysJ - 2.6.1.11,2.6.1.17 ko:K00821,ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00031,M00763,M00845 R02283,R04475,R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,Peptidase_M20 YYD3_k127_6414725_2 1191523.MROS_0162 1.866e-92 311.0 COG0548@1|root,COG0548@2|Bacteria 2|Bacteria E Belongs to the acetylglutamate kinase family. ArgB subfamily lysZ GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8,3.5.1.16 ko:K00930,ko:K01438,ko:K05828,ko:K05831 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R00669,R02649,R09107,R09776,R09779,R10930,R10933 RC00002,RC00043,RC00064,RC00090,RC00300 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Peptidase_M20 YYD3_k127_6414725_3 880073.Calab_0347 1.582e-43 164.0 COG0121@1|root,COG0121@2|Bacteria 2|Bacteria S cellular modified histidine biosynthetic process - - - - - - - - - - - - GATase_4 YYD3_k127_6435813_0 309798.COPRO5265_1547 1.885e-129 423.0 COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,248WC@186801|Clostridia,42FKS@68295|Thermoanaerobacterales 186801|Clostridia E Beta-eliminating lyase tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase YYD3_k127_6435813_1 1379698.RBG1_1C00001G1794 2.744e-80 281.0 COG4448@1|root,COG4448@2|Bacteria 2|Bacteria E L-asparaginase II ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase_II YYD3_k127_6435813_2 313624.NSP_26320 2.509e-49 194.0 COG0318@1|root,COG0318@2|Bacteria,1G3MS@1117|Cyanobacteria,1HIUD@1161|Nostocales 1117|Cyanobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding YYD3_k127_6435813_3 1379698.RBG1_1C00001G0247 2.264e-19 88.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity - - - - - - - - - - - - SpoIIE YYD3_k127_6443273_2 1379698.RBG1_1C00001G0964 4.008e-36 144.0 COG2050@1|root,COG2050@2|Bacteria,2NQ0Q@2323|unclassified Bacteria 2|Bacteria Q Thioesterase superfamily - - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - 4HBT YYD3_k127_6443273_0 459349.CLOAM0099 1.206e-64 250.0 COG2234@1|root,COG2234@2|Bacteria,2NQ2F@2323|unclassified Bacteria 2|Bacteria S Peptidase family M28 - - 3.4.11.10 ko:K05994 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M28 YYD3_k127_6443273_4 1444309.JAQG01000022_gene1478 0.0003055 52.0 COG1475@1|root,COG1475@2|Bacteria,1V8HN@1239|Firmicutes,4HJ7P@91061|Bacilli,272KB@186822|Paenibacillaceae 91061|Bacilli K ParB-like nuclease domain - - - - - - - - - - - - ParBc YYD3_k127_6443273_3 525367.HMPREF0556_12327 4.553e-09 60.0 COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,4HNJS@91061|Bacilli,26KZ6@186820|Listeriaceae 91061|Bacilli J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p YYD3_k127_6443273_1 1379698.RBG1_1C00001G1752 5.641e-41 156.0 COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria 2|Bacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN YYD3_k127_644393_0 1283300.ATXB01000001_gene1749 1.949e-87 292.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1XDJM@135618|Methylococcales 135618|Methylococcales C Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N YYD3_k127_6481301_1 1379698.RBG1_1C00001G1089 1.24e-37 153.0 COG3437@1|root,COG3437@2|Bacteria,2NP8B@2323|unclassified Bacteria 2|Bacteria T metal-dependent phosphohydrolase HD region - - - - - - - - - - - - GAF,GAF_2,GGDEF,HD,HD_5,PAS,PAS_3,PAS_9,Response_reg YYD3_k127_6481301_0 1408823.AXUS01000020_gene2131 6.22e-91 309.0 COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia 186801|Clostridia H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM YYD3_k127_6481301_2 1379698.RBG1_1C00001G0540 0.0001362 55.0 COG1520@1|root,COG1520@2|Bacteria,2NQ51@2323|unclassified Bacteria 2|Bacteria O NHL repeat containing protein - - - - - - - - - - - - PQQ_2,SBBP YYD3_k127_6491834_4 1117108.PAALTS15_07454 1.388e-10 70.0 COG0791@1|root,COG0791@2|Bacteria,1TP24@1239|Firmicutes,4HA77@91061|Bacilli,26XBX@186822|Paenibacillaceae 91061|Bacilli M NlpC/P60 family - - - ko:K19224,ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - CBM50 - Cu_amine_oxidN1,LysM,NLPC_P60 YYD3_k127_6491834_3 997346.HMPREF9374_3758 1.117e-32 133.0 COG1762@1|root,COG1762@2|Bacteria,1UK64@1239|Firmicutes,4ITII@91061|Bacilli 91061|Bacilli GT Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - - - - - - - - - - PTS_EIIA_2 YYD3_k127_6491834_2 945713.IALB_3017 9.514e-35 145.0 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination - - - - - - - - - - - - EamA YYD3_k127_6491834_1 1278309.KB907099_gene2766 1.875e-35 144.0 arCOG09454@1|root,30G4A@2|Bacteria,1N61J@1224|Proteobacteria,1SRHG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - YYD3_k127_6491834_0 1313301.AUGC01000016_gene837 2.22e-315 987.0 COG0542@1|root,COG0542@2|Bacteria,4NGEM@976|Bacteroidetes 976|Bacteroidetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N YYD3_k127_6491834_5 6326.BUX.s01254.297 2.092e-06 49.0 COG0484@1|root,COG0652@1|root,KOG0715@2759|Eukaryota,KOG0883@2759|Eukaryota,38E53@33154|Opisthokonta,3BAAP@33208|Metazoa,3CV1G@33213|Bilateria,40CER@6231|Nematoda,1KU4U@119089|Chromadorea 33208|Metazoa O Rtf2 RING-finger PPIL2 GO:0000003,GO:0000209,GO:0000375,GO:0000377,GO:0000398,GO:0000413,GO:0002376,GO:0003006,GO:0003674,GO:0003755,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005796,GO:0005886,GO:0006139,GO:0006396,GO:0006397,GO:0006464,GO:0006725,GO:0006807,GO:0006928,GO:0007275,GO:0007530,GO:0008104,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0012505,GO:0016020,GO:0016070,GO:0016071,GO:0016477,GO:0016567,GO:0016740,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0018992,GO:0019538,GO:0019787,GO:0022414,GO:0031974,GO:0031981,GO:0032446,GO:0032501,GO:0032502,GO:0033036,GO:0034450,GO:0034613,GO:0034641,GO:0036211,GO:0040011,GO:0040021,GO:0040022,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048856,GO:0048870,GO:0050900,GO:0051179,GO:0051641,GO:0051674,GO:0061630,GO:0061659,GO:0070013,GO:0070647,GO:0070727,GO:0071704,GO:0071944,GO:0072657,GO:0072659,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1990778 5.2.1.8 ko:K10598 ko04120,map04120 - - - ko00000,ko00001,ko01000,ko03041,ko03110,ko04121 - - - Pro_isomerase,Rtf2 YYD3_k127_6501181_5 290318.Cvib_0335 8.106e-68 241.0 COG0157@1|root,COG0157@2|Bacteria,1FDAY@1090|Chlorobi 1090|Chlorobi H Belongs to the NadC ModD family - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N YYD3_k127_6501181_3 1379698.RBG1_1C00001G0213 2.159e-80 278.0 COG0059@1|root,COG0059@2|Bacteria,2NNKS@2323|unclassified Bacteria 2|Bacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iHN637.CLJU_RS07505,iIT341.HP0330,iLF82_1304.LF82_1103 IlvC,IlvN YYD3_k127_6501181_4 1191523.MROS_1425 6.207e-79 290.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - CarbopepD_reg_2,Plug,TonB_dep_Rec YYD3_k127_6501181_14 1254432.SCE1572_25105 1.389e-10 73.0 2DP1D@1|root,3304P@2|Bacteria,1R5XI@1224|Proteobacteria,4386M@68525|delta/epsilon subdivisions,2X9ZN@28221|Deltaproteobacteria,2YVZY@29|Myxococcales 28221|Deltaproteobacteria S HmuY protein - - - - - - - - - - - - HmuY YYD3_k127_6501181_8 483219.LILAB_31320 8.158e-59 228.0 COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2WWSG@28221|Deltaproteobacteria,2YVBS@29|Myxococcales 28221|Deltaproteobacteria M Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - HEAT_2,Pro_isomerase YYD3_k127_6501181_7 330779.Saci_1629 6.58e-62 216.0 COG1839@1|root,arCOG04298@2157|Archaea,2XQ7K@28889|Crenarchaeota 28889|Crenarchaeota L PFAM Adenosine specific kinase - - - ko:K09129 - - - - ko00000 - - - Adenosine_kin YYD3_k127_6501181_10 1173024.KI912149_gene5832 7.183e-45 175.0 COG0454@1|root,COG0456@2|Bacteria,1GD5Y@1117|Cyanobacteria,1JHKK@1189|Stigonemataceae 1117|Cyanobacteria K GNAT acetyltransferase - - - - - - - - - - - - Acetyltransf_1,FR47 YYD3_k127_6501181_0 1042163.BRLA_c019800 4.561e-178 577.0 COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,4HA7X@91061|Bacilli,26TZM@186822|Paenibacillaceae 91061|Bacilli E oligoendopeptidase F yjbG - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N YYD3_k127_6501181_13 1382359.JIAL01000001_gene1822 1.945e-16 82.0 2ESJ3@1|root,33K3T@2|Bacteria,3Y8Y6@57723|Acidobacteria,2JNTF@204432|Acidobacteriia 204432|Acidobacteriia S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM YYD3_k127_6501181_9 653733.Selin_1349 1.11e-49 183.0 COG4843@1|root,COG4843@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179 YYD3_k127_6501181_2 1379698.RBG1_1C00001G0202 1.286e-119 392.0 COG1721@1|root,COG1721@2|Bacteria,2NP6B@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 YYD3_k127_6501181_1 1379698.RBG1_1C00001G0201 1.581e-149 479.0 COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria 2|Bacteria O ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 YYD3_k127_6501181_12 880073.Calab_0240 2.197e-24 108.0 COG1664@1|root,COG1664@2|Bacteria,2NQ1N@2323|unclassified Bacteria 2|Bacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin YYD3_k127_6501181_11 484770.UFO1_2322 3.336e-28 124.0 COG0739@1|root,COG0739@2|Bacteria,1TRWJ@1239|Firmicutes 1239|Firmicutes M peptidase - - - - - - - - - - - - G5,LysM,Peptidase_M23 YYD3_k127_6501181_6 1048834.TC41_3300 1.311e-67 238.0 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H9TB@91061|Bacilli,27886@186823|Alicyclobacillaceae 91061|Bacilli K Belongs to the ParB family spo0J GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - HTH_3,KorB,ParBc YYD3_k127_6518055_9 1321778.HMPREF1982_03794 2.91e-27 122.0 COG0438@1|root,COG0438@2|Bacteria,1TSNT@1239|Firmicutes,248MH@186801|Clostridia 186801|Clostridia M Group 1 family - - - - - - - - - - - - Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 YYD3_k127_6518055_6 1379698.RBG1_1C00001G0384 4.563e-44 176.0 COG0438@1|root,COG0438@2|Bacteria,2NPP9@2323|unclassified Bacteria 2|Bacteria M Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 YYD3_k127_6518055_4 1379698.RBG1_1C00001G0386 4.707e-55 204.0 COG1216@1|root,COG1216@2|Bacteria,2NP9Z@2323|unclassified Bacteria 2|Bacteria GM Glycosyltransferase like family 2 wbbL - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2 YYD3_k127_6518055_10 880073.Calab_0041 1.914e-25 112.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 1.14.18.1 ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 - - - BNR,FlgD_ig,Peptidase_S74,Tyrosinase YYD3_k127_6518055_8 1121101.HMPREF1532_01912 3.628e-32 143.0 COG4870@1|root,COG4870@2|Bacteria,4PNXD@976|Bacteroidetes,2G101@200643|Bacteroidia 976|Bacteroidetes O Propeptide_C25 - - - - - - - - - - - - Peptidase_C25,Propeptide_C25 YYD3_k127_6518055_7 635013.TherJR_2169 8.493e-33 133.0 COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,261XI@186807|Peptococcaceae 186801|Clostridia K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ YYD3_k127_6518055_3 1121423.JONT01000001_gene2052 1.126e-74 261.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,260DT@186807|Peptococcaceae 186801|Clostridia J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 YYD3_k127_6518055_1 517418.Ctha_0827 7.244e-98 345.0 COG0768@1|root,COG2815@1|root,COG0768@2|Bacteria,COG2815@2|Bacteria,1FDDH@1090|Chlorobi 1090|Chlorobi M PFAM penicillin-binding protein transpeptidase - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase YYD3_k127_6518055_0 644966.Tmar_0865 9.435e-122 408.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3WCXE@538999|Clostridiales incertae sedis 186801|Clostridia M to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M YYD3_k127_6518055_2 1379698.RBG1_1C00001G0392 1.052e-79 284.0 COG0770@1|root,COG0770@2|Bacteria,2NP4Q@2323|unclassified Bacteria 2|Bacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M YYD3_k127_6518055_5 1379698.RBG1_1C00001G0393 6.298e-46 171.0 COG0472@1|root,COG0472@2|Bacteria,2NNQW@2323|unclassified Bacteria 2|Bacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 YYD3_k127_6551528_0 1379698.RBG1_1C00001G0761 4.437e-125 416.0 COG0008@1|root,COG0008@2|Bacteria,2NNMZ@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c YYD3_k127_6551528_5 1121918.ARWE01000001_gene1253 0.0001163 51.0 COG1633@1|root,COG1633@2|Bacteria,1NEYR@1224|Proteobacteria,42VA3@68525|delta/epsilon subdivisions,2WS93@28221|Deltaproteobacteria,43SR0@69541|Desulfuromonadales 28221|Deltaproteobacteria S Rubrerythrin - - - - - - - - - - - - Rubrerythrin YYD3_k127_6551528_4 760568.Desku_0069 1.101e-10 64.0 COG1592@1|root,COG1592@2|Bacteria,1VB12@1239|Firmicutes,24JQ6@186801|Clostridia,262FT@186807|Peptococcaceae 186801|Clostridia C PFAM Rubredoxin-type Fe(Cys)4 protein - - - - - - - - - - - - - YYD3_k127_6551528_3 926569.ANT_29600 1.003e-42 162.0 COG0695@1|root,COG1225@1|root,COG0695@2|Bacteria,COG1225@2|Bacteria,2G6XD@200795|Chloroflexi 200795|Chloroflexi O Redoxin - - - - - - - - - - - - AhpC-TSA YYD3_k127_6551528_1 1382315.JPOI01000001_gene1340 3.764e-108 362.0 COG0492@1|root,COG0492@2|Bacteria,1TRPN@1239|Firmicutes,4H9V7@91061|Bacilli,1WEJX@129337|Geobacillus 91061|Bacilli C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase yumC - 1.18.1.2,1.19.1.1 ko:K21567 - - - - ko00000,ko01000 - - iYO844.BSU32110 Pyr_redox_2 YYD3_k127_6551528_2 1379698.RBG1_1C00001G1873 1.324e-63 224.0 COG0379@1|root,COG0379@2|Bacteria,2NP47@2323|unclassified Bacteria 2|Bacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA YYD3_k127_6561342_2 945713.IALB_0845 1.162e-24 109.0 COG1295@1|root,COG1295@2|Bacteria 2|Bacteria S lipopolysaccharide transmembrane transporter activity rbn - - ko:K03303,ko:K07058 - - - - ko00000,ko02000 2.A.14 - - Virul_fac_BrkB YYD3_k127_6561342_1 358681.BBR47_51240 2.047e-75 262.0 COG0454@1|root,COG0456@2|Bacteria,1V40T@1239|Firmicutes,4HI2H@91061|Bacilli,26YNM@186822|Paenibacillaceae 91061|Bacilli K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 YYD3_k127_6561342_0 1121920.AUAU01000007_gene487 1.489e-123 407.0 COG0436@1|root,COG0436@2|Bacteria,3Y2IZ@57723|Acidobacteria 57723|Acidobacteria E PFAM aminotransferase, class I - - - - - - - - - - - - Aminotran_1_2 YYD3_k127_6562008_0 1379698.RBG1_1C00001G1312 6.762e-28 123.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity plnP - - ko:K07052 - - - - ko00000 - - - Abi YYD3_k127_6562008_3 296591.Bpro_2918 0.0002055 51.0 COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2VM3G@28216|Betaproteobacteria,4AC44@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM CHAD domain containing protein - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHAD,CYTH YYD3_k127_6563717_0 1210884.HG799463_gene9843 2.479e-233 732.0 COG3256@1|root,COG3256@2|Bacteria,2J2IF@203682|Planctomycetes 203682|Planctomycetes P Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 YYD3_k127_6574722_8 42256.RradSPS_0047 5.447e-17 92.0 2DFV5@1|root,2ZT9W@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_6574722_12 1120978.KB894080_gene1353 0.0003596 49.0 29XWE@1|root,30JNT@2|Bacteria,1UW1M@1239|Firmicutes,4IC1J@91061|Bacilli,27GXQ@186828|Carnobacteriaceae 91061|Bacilli S Domain of unknown function (DUF4430) - - - - - - - - - - - - DUF4430 YYD3_k127_6574722_1 237368.SCABRO_03353 7.273e-85 289.0 COG2877@1|root,COG2877@2|Bacteria,2IXME@203682|Planctomycetes 203682|Planctomycetes M 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 YYD3_k127_6574722_5 522772.Dacet_1305 8.422e-36 142.0 COG1778@1|root,COG1778@2|Bacteria,2GFN9@200930|Deferribacteres 200930|Deferribacteres S haloacid dehalogenase-like hydrolase - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 YYD3_k127_6574722_0 1379698.RBG1_1C00001G0545 1.998e-98 331.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,2NNNB@2323|unclassified Bacteria 2|Bacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 2.5.1.55,5.3.1.13 ko:K01627,ko:K03281,ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530,R03254 RC00435,RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 2.A.49 - iAF987.Gmet_1278 CBS,SIS YYD3_k127_6574722_3 1380394.JADL01000002_gene1467 1.046e-57 207.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2U0HE@28211|Alphaproteobacteria,2JZEK@204441|Rhodospirillales 204441|Rhodospirillales E threonine efflux protein - - - - - - - - - - - - LysE YYD3_k127_6574722_2 1379698.RBG1_1C00001G0547 1.491e-69 246.0 COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria 2|Bacteria M Lipid A biosynthesis htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans YYD3_k127_6574722_6 1379698.RBG1_1C00001G0548 5.58e-32 131.0 COG3117@1|root,COG3117@2|Bacteria,2NQ8Q@2323|unclassified Bacteria 2|Bacteria S Lipopolysaccharide-assembly, LptC-related lptC - - ko:K09774,ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC YYD3_k127_6574722_10 1202532.FF52_20687 5.899e-09 65.0 COG0746@1|root,COG0746@2|Bacteria,4NQQT@976|Bacteroidetes,1IIZW@117743|Flavobacteriia,2NUCX@237|Flavobacterium 976|Bacteroidetes H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 YYD3_k127_6574722_11 1122994.AUFR01000004_gene712 1.996e-08 60.0 COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4DRFZ@85009|Propionibacteriales 201174|Actinobacteria L Helix-hairpin-helix motif comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB YYD3_k127_6574722_4 1379281.AVAG01000009_gene607 4.236e-55 197.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2MBFU@213115|Desulfovibrionales 28221|Deltaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like YYD3_k127_6574722_9 1236976.JCM16418_4808 1.244e-15 80.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,4H9X4@91061|Bacilli,26R3F@186822|Paenibacillaceae 91061|Bacilli J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon YYD3_k127_657516_1 1379698.RBG1_1C00001G1751 4.205e-50 203.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2NP4I@2323|unclassified Bacteria 2|Bacteria U Metallo-beta-lactamase superfamily comEC - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B YYD3_k127_657516_0 1379698.RBG1_1C00001G1752 2.239e-73 262.0 COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria 2|Bacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN YYD3_k127_6586480_6 945713.IALB_2682 2.808e-11 64.0 2B2YN@1|root,31VJM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_6586480_7 485913.Krac_8724 2.111e-09 65.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family - - - - - - - - - - - - DinB_2 YYD3_k127_6586480_1 1395587.P364_0129145 5.051e-67 237.0 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,4H9QA@91061|Bacilli,26RR9@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase YYD3_k127_6586480_3 1120973.AQXL01000088_gene3230 4.26e-28 116.0 COG2314@1|root,COG2314@2|Bacteria,1VESS@1239|Firmicutes,4HP3D@91061|Bacilli 91061|Bacilli S TM2 domain - - - - - - - - - - - - - YYD3_k127_6586480_4 1211817.CCAT010000083_gene1534 9.633e-17 89.0 COG1852@1|root,COG1852@2|Bacteria,1UZ1X@1239|Firmicutes,24A38@186801|Clostridia,36EPT@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF116 - - - - - - - - - - - - DUF116 YYD3_k127_6586480_5 1123256.KB907925_gene1078 2.426e-15 83.0 COG0127@1|root,COG0454@1|root,COG0127@2|Bacteria,COG0456@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1X4DK@135614|Xanthomonadales 135614|Xanthomonadales F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Ham1p_like YYD3_k127_6586480_0 1379698.RBG1_1C00001G0688 5.999e-275 857.0 COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria 2|Bacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iAF987.Gmet_1487 GATase_6,SIS YYD3_k127_6586480_2 945713.IALB_1675 1.498e-38 150.0 COG1109@1|root,COG1109@2|Bacteria 2|Bacteria G phosphoglucosamine mutase activity glmM - 5.4.2.10,5.4.2.2,5.4.2.8 ko:K01840,ko:K03431,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R02060,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV YYD3_k127_6688594_6 714943.Mucpa_6403 1.833e-06 53.0 COG2301@1|root,COG2301@2|Bacteria,4NJ95@976|Bacteroidetes,1IRJJ@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the HpcH HpaI aldolase family - - - - - - - - - - - - HpcH_HpaI YYD3_k127_6688594_3 1121403.AUCV01000005_gene233 4.406e-17 92.0 COG0457@1|root,COG0457@2|Bacteria,1R64F@1224|Proteobacteria,42Q6D@68525|delta/epsilon subdivisions,2WKT0@28221|Deltaproteobacteria,2MHV1@213118|Desulfobacterales 28221|Deltaproteobacteria S Domain of unknown function (DUF4388) - - - - - - - - - - - - DUF4388 YYD3_k127_6688594_5 313628.LNTAR_20978 6.648e-09 65.0 COG2137@1|root,COG2137@2|Bacteria 2|Bacteria S regulation of DNA repair recX GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 ko:K03565,ko:K19002 ko00561,ko01100,map00561,map01100 - R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03400 - GT4 - RecX YYD3_k127_6688594_0 1123371.ATXH01000014_gene1607 9.721e-234 751.0 COG0013@1|root,COG0013@2|Bacteria,2GH36@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD YYD3_k127_6688594_1 517418.Ctha_0722 8.533e-73 253.0 COG1646@1|root,COG1646@2|Bacteria,1FEV5@1090|Chlorobi 1090|Chlorobi I PcrB family - - - ko:K07094 - - - - ko00000,ko01000 - - - PcrB YYD3_k127_6688594_2 661478.OP10G_1458 8.441e-21 101.0 COG0241@1|root,COG0279@1|root,COG0241@2|Bacteria,COG0279@2|Bacteria 2|Bacteria G D-glycero-D-manno-heptose 7-phosphate metabolic process gmhA - 3.1.3.82,3.1.3.83,5.3.1.28 ko:K02843,ko:K03271,ko:K03273 ko00540,ko01100,map00540,map01100 M00064,M00080 R05645,R05647,R09768,R09769,R09771 RC00017,RC00434 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - HupF_HypC,Hydrolase_like,SIS_2 YYD3_k127_6699470_4 1122222.AXWR01000045_gene2365 0.0001209 45.0 COG0177@1|root,COG0177@2|Bacteria,1WI69@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD YYD3_k127_6699470_2 580331.Thit_0125 6.585e-48 183.0 COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,42F18@68295|Thermoanaerobacterales 186801|Clostridia J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 YYD3_k127_6699470_3 1191523.MROS_1441 1.029e-15 89.0 2AMSR@1|root,31CP7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - YYD3_k127_6699470_0 1379698.RBG1_1C00001G0692 3.529e-126 413.0 COG0216@1|root,COG0216@2|Bacteria,2NNKY@2323|unclassified Bacteria 2|Bacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 YYD3_k127_6699470_1 1379698.RBG1_1C00001G0691 2.383e-92 313.0 COG3872@1|root,COG3872@2|Bacteria,2NP59@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1385) prmC - - ko:K09153 - - - - ko00000 - - - DUF1385 YYD3_k127_6701954_1 1379698.RBG1_1C00001G1199 1.193e-60 230.0 COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria 2|Bacteria T Signal transduction histidine kinase, nitrogen specific, NtrB - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_9 YYD3_k127_6701954_2 1379698.RBG1_1C00001G1427 3.624e-60 214.0 COG0231@1|root,COG0231@2|Bacteria,2NPID@2323|unclassified Bacteria 2|Bacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C YYD3_k127_6701954_3 1379698.RBG1_1C00001G1425 3.308e-48 182.0 COG1039@1|root,COG1039@2|Bacteria,2NPUQ@2323|unclassified Bacteria 2|Bacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03471 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DUF3378,RNase_HII YYD3_k127_6701954_4 443143.GM18_3684 2.817e-15 80.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WMEF@28221|Deltaproteobacteria,43TIX@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_6701954_0 237368.SCABRO_00112 7.182e-91 310.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2IX5J@203682|Planctomycetes 203682|Planctomycetes H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 YYD3_k127_6719039_4 1499967.BAYZ01000080_gene910 2.096e-16 83.0 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - - - - - - - - - - - Big_5,ESPR,LVIVD,YadA_anchor,YadA_head,YadA_stalk YYD3_k127_6719039_3 1042326.AZNV01000068_gene5756 6.842e-22 111.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1NS2Y@1224|Proteobacteria,2UNZQ@28211|Alphaproteobacteria,4BI13@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Guanylate_cyc YYD3_k127_6719039_2 593750.Metfor_0341 3.364e-24 119.0 arCOG03732@1|root,arCOG07676@1|root,arCOG09612@1|root,arCOG03732@2157|Archaea,arCOG07676@2157|Archaea,arCOG09612@2157|Archaea,2Y4EU@28890|Euryarchaeota 28890|Euryarchaeota S TIR domain - - - - - - - - - - - - TIR_2 YYD3_k127_6719039_1 47763.JNZA01000035_gene2565 2.476e-46 186.0 COG0758@1|root,COG0758@2|Bacteria 2|Bacteria LU DNA mediated transformation smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A YYD3_k127_6719039_0 1121920.AUAU01000018_gene1800 1.387e-164 530.0 COG0436@1|root,COG0436@2|Bacteria,3Y5C9@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class I and II - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_6721635_1 373903.Hore_12560 1.803e-39 160.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WAE6@53433|Halanaerobiales 186801|Clostridia S CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 YYD3_k127_6721635_2 638303.Thal_0337 6.992e-23 103.0 COG0319@1|root,COG0319@2|Bacteria,2G5AR@200783|Aquificae 200783|Aquificae J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 YYD3_k127_6721635_0 880073.Calab_2813 3.285e-99 334.0 COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria 2|Bacteria S 7TM receptor with intracellular HD hydrolase yqfF - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD YYD3_k127_6725601_2 411483.FAEPRAA2165_02811 1.715e-08 64.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3WGST@541000|Ruminococcaceae 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA YYD3_k127_6725601_1 290397.Adeh_1611 3.439e-18 99.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria 1224|Proteobacteria L nucleotidyltransferase DNA polymerase involved in DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS YYD3_k127_6725601_0 479434.Sthe_0227 2.838e-59 214.0 COG0587@1|root,COG0587@2|Bacteria,2G811@200795|Chloroflexi,27Z3J@189775|Thermomicrobia 189775|Thermomicrobia L Belongs to the DNA polymerase type-C family. DnaE2 subfamily - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP YYD3_k127_6730045_8 1379698.RBG1_1C00001G1661 9.603e-17 82.0 COG1239@1|root,COG1239@2|Bacteria,2NQQG@2323|unclassified Bacteria 2|Bacteria H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX chlI - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - iNJ661.Rv0958 Mg_chelatase,Sigma54_activat YYD3_k127_6730045_0 1379698.RBG1_1C00001G1660 2.221e-133 435.0 COG4867@1|root,COG4867@2|Bacteria,2NQZ8@2323|unclassified Bacteria 2|Bacteria S von Willebrand factor (vWF) type A domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA_2 YYD3_k127_6730045_3 237368.SCABRO_00983 1.474e-68 246.0 COG2206@1|root,COG2206@2|Bacteria,2J3D3@203682|Planctomycetes 203682|Planctomycetes T signal transduction HD GYP protein - - - - - - - - - - - - HD,HD_5 YYD3_k127_6730045_9 679197.HMPREF9336_01244 4.959e-10 65.0 COG2259@1|root,COG2259@2|Bacteria,2HC2E@201174|Actinobacteria 201174|Actinobacteria S DoxX - - 1.8.5.2 ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxX YYD3_k127_6730045_5 1121403.AUCV01000039_gene4348 1.721e-39 151.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria,2MKP9@213118|Desulfobacterales 28221|Deltaproteobacteria J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP YYD3_k127_6730045_6 986075.CathTA2_2804 8.765e-38 145.0 COG0838@1|root,COG0838@2|Bacteria,1V6P3@1239|Firmicutes,4HIFX@91061|Bacilli 91061|Bacilli C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 YYD3_k127_6730045_4 1279009.ADICEAN_01551 3.126e-62 219.0 COG0377@1|root,COG0377@2|Bacteria,4NFKT@976|Bacteroidetes,47JYD@768503|Cytophagia 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 YYD3_k127_6730045_7 1131269.AQVV01000025_gene2341 8.606e-27 115.0 COG0852@1|root,COG0852@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa YYD3_k127_6730045_1 237368.SCABRO_02007 1.486e-76 262.0 COG0649@1|root,COG0649@2|Bacteria,2IY7J@203682|Planctomycetes 203682|Planctomycetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa YYD3_k127_6737480_1 1379698.RBG1_1C00001G1263 3.486e-103 365.0 COG1404@1|root,COG1404@2|Bacteria,2NNSK@2323|unclassified Bacteria 2|Bacteria O Subtilase family aprN - - - - - - - - - - - Peptidase_S8 YYD3_k127_6737480_3 504487.JCM19302_2841 2.909e-05 57.0 COG3291@1|root,COG4935@1|root,COG3291@2|Bacteria,COG4935@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia 976|Bacteroidetes DZ adhesin AidA-related - - - - - - - - - - - - CHU_C,PKD,SprB YYD3_k127_6737480_0 941824.TCEL_02364 1.293e-131 431.0 COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,36E9B@31979|Clostridiaceae 186801|Clostridia E aminopeptidase - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 YYD3_k127_6737480_2 1027292.HMPREF9372_3586 1.355e-29 127.0 COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,4HE7X@91061|Bacilli,26ETR@186818|Planococcaceae 91061|Bacilli S Pyrophosphatase PpaX ppaX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.1 ko:K06019 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - HAD_2 YYD3_k127_6766626_2 1379698.RBG1_1C00001G0350 5.595e-52 202.0 COG1196@1|root,COG1196@2|Bacteria,2NNSS@2323|unclassified Bacteria 2|Bacteria D nuclear chromosome segregation - - - - - - - - - - - - - YYD3_k127_6766626_1 1379698.RBG1_1C00001G0352 1.132e-60 233.0 COG0457@1|root,COG0457@2|Bacteria,2NRR4@2323|unclassified Bacteria 2|Bacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 YYD3_k127_6766626_0 1379698.RBG1_1C00001G0356 5.447e-81 286.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,2NS3S@2323|unclassified Bacteria 2|Bacteria EG Protein of unknown function (DUF2723) - - - ko:K16928 - M00582 - - ko00000,ko00002,ko02000 3.A.1.33 - - DUF2723,QueT YYD3_k127_6774641_2 1048983.EL17_01565 1.525e-56 204.0 COG2217@1|root,COG2217@2|Bacteria,4NEI1@976|Bacteroidetes,47N4X@768503|Cytophagia 976|Bacteroidetes P ATPase, P-type (transporting), HAD superfamily, subfamily IC ccoI - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase YYD3_k127_6774641_0 1304874.JAFY01000001_gene2572 4.753e-289 899.0 COG1217@1|root,COG1217@2|Bacteria,3T9TF@508458|Synergistetes 508458|Synergistetes T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 YYD3_k127_6774641_1 1379698.RBG1_1C00001G0553 3.323e-132 428.0 COG1493@1|root,COG1493@2|Bacteria,2NP5B@2323|unclassified Bacteria 2|Bacteria T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N YYD3_k127_6774641_3 1379698.RBG1_1C00001G0706 2.129e-09 64.0 COG0760@1|root,COG0760@2|Bacteria,2NR9Y@2323|unclassified Bacteria 2|Bacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769,ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3,TPR_7 YYD3_k127_6775803_2 1379698.RBG1_1C00001G0691 1.529e-58 211.0 COG3872@1|root,COG3872@2|Bacteria,2NP59@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1385) prmC - - ko:K09153 - - - - ko00000 - - - DUF1385 YYD3_k127_6775803_4 269799.Gmet_0377 2.274e-25 109.0 COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2WRGA@28221|Deltaproteobacteria,43VM9@69541|Desulfuromonadales 28221|Deltaproteobacteria J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 YYD3_k127_6775803_3 1396141.BATP01000007_gene5722 3.774e-34 139.0 COG0500@1|root,COG2226@2|Bacteria,46V7M@74201|Verrucomicrobia 74201|Verrucomicrobia Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_25 YYD3_k127_6775803_5 237368.SCABRO_01366 6.949e-16 85.0 COG0655@1|root,COG0655@2|Bacteria,2J3H1@203682|Planctomycetes 203682|Planctomycetes S Flavodoxin-like fold - - - - - - - - - - - - FMN_red YYD3_k127_6775803_0 1545701.LACWKB10_1322 5.099e-126 425.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HBVV@91061|Bacilli,3F3QI@33958|Lactobacillaceae 91061|Bacilli S ABC transporter, ATP-binding protein ydiF - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn YYD3_k127_6775803_1 1379698.RBG1_1C00001G0208 3.336e-106 370.0 COG2304@1|root,COG2304@2|Bacteria,2NPT8@2323|unclassified Bacteria 2|Bacteria S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA YYD3_k127_6785920_3 194439.CT2009 2.83e-32 131.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,1FDC1@1090|Chlorobi 1090|Chlorobi EG Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 YYD3_k127_6785920_4 518766.Rmar_0030 1.692e-21 99.0 COG0781@1|root,COG0781@2|Bacteria,4NDVR@976|Bacteroidetes,1FJJ7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB YYD3_k127_6785920_1 1123325.JHUV01000002_gene125 1.703e-62 218.0 COG0054@1|root,COG0054@2|Bacteria,2G3YV@200783|Aquificae 200783|Aquificae H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase YYD3_k127_6785920_0 945713.IALB_2105 1.816e-164 527.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria 2|Bacteria H GTP cyclohydrolase II activity ribBA - 3.5.4.25,4.1.99.12 ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 YYD3_k127_6785920_2 1123371.ATXH01000004_gene1796 5.995e-51 188.0 COG0307@1|root,COG0307@2|Bacteria,2GGV7@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H Lumazine binding domain - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding YYD3_k127_6816800_6 3218.PP1S175_129V6.1 1.37e-20 93.0 COG0079@1|root,KOG0633@2759|Eukaryota,37KF6@33090|Viridiplantae,3GBQN@35493|Streptophyta 35493|Streptophyta E Histidinol-phosphate aminotransferase - GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_6816800_3 1267533.KB906739_gene2679 3.451e-39 151.0 COG2120@1|root,COG2120@2|Bacteria,3Y3NP@57723|Acidobacteria,2JIEH@204432|Acidobacteriia 204432|Acidobacteriia S GlcNAc-PI de-N-acetylase - - - ko:K01463 - - - - ko00000,ko01000 - - - PIG-L YYD3_k127_6816800_1 1379698.RBG1_1C00001G1765 4.657e-128 419.0 COG0438@1|root,COG0438@2|Bacteria,2NNTN@2323|unclassified Bacteria 2|Bacteria M Glycosyl transferases group 1 bshA GO:0003674,GO:0003824,GO:0016740,GO:0016757 - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 YYD3_k127_6816800_2 1379698.RBG1_1C00001G1766 3.222e-102 352.0 COG4365@1|root,COG4365@2|Bacteria,2NP8Q@2323|unclassified Bacteria 2|Bacteria S Bacillithiol biosynthesis BshC bshC - - ko:K22136 - - - - ko00000 - - - BshC YYD3_k127_6816800_0 1121428.DESHY_110474___1 1.732e-254 820.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,263ZP@186807|Peptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran YYD3_k127_6816800_4 1182590.BN5_01997 3.843e-34 144.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1YFG5@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 YYD3_k127_6816800_5 944481.JAFP01000001_gene393 4.047e-26 123.0 COG1538@1|root,COG1538@2|Bacteria,1PTZ6@1224|Proteobacteria,42RK2@68525|delta/epsilon subdivisions,2WNMB@28221|Deltaproteobacteria,2M70F@213113|Desulfurellales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP YYD3_k127_6816800_7 935948.KE386495_gene1155 2.005e-13 78.0 COG1309@1|root,COG1309@2|Bacteria,1TRSH@1239|Firmicutes,25B0B@186801|Clostridia,42GEJ@68295|Thermoanaerobacterales 186801|Clostridia K regulator, TetR-like, DNA-binding, bacterial archaeal - - - - - - - - - - - - TetR_C_4,TetR_N YYD3_k127_6819160_0 926550.CLDAP_04870 6.615e-77 284.0 COG2133@1|root,COG2133@2|Bacteria,2G62S@200795|Chloroflexi 200795|Chloroflexi G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH YYD3_k127_6819160_1 1121918.ARWE01000001_gene1797 1.21e-50 203.0 COG1404@1|root,COG1404@2|Bacteria,1QYWU@1224|Proteobacteria,42VXP@68525|delta/epsilon subdivisions,2X7PK@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - YYD3_k127_6830760_0 485913.Krac_8040 9.477e-27 123.0 COG2114@1|root,COG2114@2|Bacteria 2|Bacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - DA1-like,GAF,Guanylate_cyc,HAMP,PAS_4,PAS_9,Response_reg,dCache_1 YYD3_k127_6830760_1 880073.Calab_3071 7.213e-25 123.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,DUF11,Flg_new,SLH YYD3_k127_6834131_2 1121957.ATVL01000008_gene4553 5.035e-26 125.0 COG5295@1|root,COG5295@2|Bacteria,4NKG1@976|Bacteroidetes,47NK6@768503|Cytophagia 976|Bacteroidetes MUW domain, Protein - - - - - - - - - - - - Peptidase_S74 YYD3_k127_6834131_4 1379698.RBG1_1C00001G0237 8.995e-11 75.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Calx-beta,LVIVD YYD3_k127_6834131_0 926550.CLDAP_14520 1.888e-82 284.0 COG0111@1|root,COG0111@2|Bacteria 2|Bacteria EH 4-phosphoerythronate dehydrogenase activity - - 1.1.1.399,1.1.1.95,1.17.1.9 ko:K00058,ko:K00122 ko00260,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00519,R01513 RC00031,RC02796 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C YYD3_k127_6834131_6 635013.TherJR_2859 2.415e-08 69.0 COG4412@1|root,COG5184@1|root,COG5492@1|root,COG4412@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1TS5I@1239|Firmicutes,24A8Z@186801|Clostridia,261X1@186807|Peptococcaceae 186801|Clostridia DZ regulator of chromosome condensation, RCC1 - - - - - - - - - - - - Beta_helix,Big_2,CHB_HEX_C_1,CW_binding_2,Cu_amine_oxidN1,RCC1,RCC1_2 YYD3_k127_6834131_3 1121930.AQXG01000001_gene1125 1.463e-19 106.0 COG0737@1|root,COG1506@1|root,COG0737@2|Bacteria,COG1506@2|Bacteria,4NQQD@976|Bacteroidetes 976|Bacteroidetes E Lamin Tail Domain - - - - - - - - - - - - Calx-beta,LTD YYD3_k127_6834131_1 1192034.CAP_8119 2.378e-50 198.0 COG5184@1|root,COG5184@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria,2YV9Z@29|Myxococcales 28221|Deltaproteobacteria DZ Thrombospondin type 3 repeat - - - - - - - - - - - - TSP_3 YYD3_k127_6834131_7 1215092.PA6_033_00770 2.6e-05 53.0 2DN7J@1|root,32VZC@2|Bacteria,1N6CR@1224|Proteobacteria,1SAGW@1236|Gammaproteobacteria,1YGRC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ YYD3_k127_6837057_3 1449126.JQKL01000083_gene3131 1.041e-19 90.0 COG2208@1|root,COG2208@2|Bacteria,1TQ92@1239|Firmicutes,247XG@186801|Clostridia,267WD@186813|unclassified Clostridiales 186801|Clostridia KT Sigma factor PP2C-like phosphatases spoIIE - 3.1.3.16 ko:K06382 - - - - ko00000,ko01000 - - - SpoIIE YYD3_k127_6837057_2 404589.Anae109_2915 1.091e-55 202.0 COG2010@1|root,COG2010@2|Bacteria,1RBTK@1224|Proteobacteria,43AHK@68525|delta/epsilon subdivisions,2X5XT@28221|Deltaproteobacteria,2YVZ8@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c - - - - - - - - - - - - - YYD3_k127_6837057_0 330214.NIDE0362 6.481e-184 594.0 COG0445@1|root,COG0445@2|Bacteria,3J0E9@40117|Nitrospirae 40117|Nitrospirae D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc YYD3_k127_6837057_4 314232.SKA53_11868 1.26e-09 66.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2U9T9@28211|Alphaproteobacteria,2P95D@245186|Loktanella 28211|Alphaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB YYD3_k127_6837057_1 697281.Mahau_2951 4.536e-85 286.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,42F5R@68295|Thermoanaerobacterales 186801|Clostridia D PFAM Cobyrinic acid a,c-diamide synthase soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 YYD3_k127_6838307_16 189426.PODO_16020 8.968e-05 50.0 COG0642@1|root,COG2205@2|Bacteria,1VS9T@1239|Firmicutes,4IS7H@91061|Bacilli,26UAF@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA YYD3_k127_6838307_2 1379698.RBG1_1C00001G0675 5.075e-95 331.0 COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria 2|Bacteria E Saccharopine dehydrogenase C-terminal domain lysDH - 1.4.1.18 ko:K19064 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R00446,R02317 RC00062,RC00694 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP YYD3_k127_6838307_12 1131814.JAFO01000001_gene1828 2.24e-06 58.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2U7GY@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU general secretion pathway protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG YYD3_k127_6838307_15 1123377.AUIV01000012_gene770 6.195e-05 55.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S69B@1236|Gammaproteobacteria,1X6DG@135614|Xanthomonadales 135614|Xanthomonadales NU General secretion pathway protein xpsG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG YYD3_k127_6838307_17 765912.Thimo_0046 0.0001412 54.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales 135613|Chromatiales U general secretion pathway protein G - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG YYD3_k127_6838307_13 1502770.JQMG01000001_gene15 3.266e-05 55.0 COG2165@1|root,COG2165@2|Bacteria,1N0UD@1224|Proteobacteria,2W2VV@28216|Betaproteobacteria 28216|Betaproteobacteria NU general secretion pathway protein - - - - - - - - - - - - N_methyl YYD3_k127_6838307_8 1379698.RBG1_1C00001G0093 4.316e-30 123.0 COG0633@1|root,COG0633@2|Bacteria 2|Bacteria C Ferredoxin fdx GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 - ko:K04755 - - - - ko00000 - - - Fer2 YYD3_k127_6838307_7 1379698.RBG1_1C00001G0095 6.082e-33 131.0 COG0316@1|root,COG0316@2|Bacteria,2NPZK@2323|unclassified Bacteria 2|Bacteria S Belongs to the HesB IscA family ycf57 GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:1901564 - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn YYD3_k127_6838307_9 349161.Dred_2964 1.935e-26 113.0 COG1959@1|root,COG1959@2|Bacteria,1VA5B@1239|Firmicutes,24JMN@186801|Clostridia 186801|Clostridia K transcriptional regulator, Rrf2 family - - - - - - - - - - - - Rrf2 YYD3_k127_6838307_1 1379698.RBG1_1C00001G1877 7.678e-123 400.0 COG0214@1|root,COG0214@2|Bacteria,2NNZ6@2323|unclassified Bacteria 2|Bacteria H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively pdxS GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ YYD3_k127_6838307_6 1480694.DC28_00505 4.23e-47 176.0 COG0311@1|root,COG0311@2|Bacteria,2J80A@203691|Spirochaetes 203691|Spirochaetes H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SNO YYD3_k127_6838307_3 1382306.JNIM01000001_gene701 1.248e-93 316.0 COG0320@1|root,COG0320@2|Bacteria,2G5MH@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM YYD3_k127_6838307_4 1379698.RBG1_1C00001G1880 1.535e-69 246.0 COG0761@1|root,COG0761@2|Bacteria,2NP7K@2323|unclassified Bacteria 2|Bacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - iIT341.HP0400,iLJ478.TM1444 LYTB,S1 YYD3_k127_6838307_0 1379698.RBG1_1C00001G1882 1.321e-167 554.0 COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm YYD3_k127_6838307_10 530564.Psta_2904 1.093e-16 83.0 COG2146@1|root,COG2146@2|Bacteria,2J0FX@203682|Planctomycetes 203682|Planctomycetes P COG2146 Ferredoxin subunits of nitrite reductase and - - 1.7.1.15 ko:K00363,ko:K05710 ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske YYD3_k127_6838307_5 1379698.RBG1_1C00001G0810 4.192e-67 234.0 COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria 2|Bacteria S Methyltransferase domain yrrM - 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_3 YYD3_k127_6838307_14 264199.stu0997 3.742e-05 53.0 COG1393@1|root,COG1393@2|Bacteria,1V3QC@1239|Firmicutes,4HH0I@91061|Bacilli 91061|Bacilli K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress spxA - - ko:K16509 - - - - ko00000 - - - ArsC YYD3_k127_6843490_3 1089551.KE386572_gene3425 1.675e-26 113.0 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,4BSCN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J 2'-5' RNA ligase superfamily ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase YYD3_k127_6843490_1 243233.MCA2183 9.259e-76 258.0 COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,1S3N1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 YYD3_k127_6843490_0 880073.Calab_3769 7.965e-251 792.0 COG1770@1|root,COG1770@2|Bacteria,2NNMF@2323|unclassified Bacteria 2|Bacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N YYD3_k127_6843490_2 1032480.MLP_26610 5.21e-64 228.0 COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4DQCW@85009|Propionibacteriales 201174|Actinobacteria GK ROK family ppgK - 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK YYD3_k127_6846998_0 1379698.RBG1_1C00001G1339 1.551e-80 275.0 COG1297@1|root,COG1297@2|Bacteria,2NP0C@2323|unclassified Bacteria 2|Bacteria S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT YYD3_k127_6846998_1 1379698.RBG1_1C00001G0373 4.151e-35 144.0 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_5,Cadherin_3,Cleaved_Adhesin,FlgD_ig,HemolysinCabind,Kelch_1,Kelch_4,OmpA_membrane YYD3_k127_6850028_3 344747.PM8797T_10689 1.011e-111 367.0 COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes 203682|Planctomycetes E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 YYD3_k127_6850028_5 880073.Calab_1657 1.434e-82 288.0 COG1408@1|root,COG1408@2|Bacteria,2NRFJ@2323|unclassified Bacteria 2|Bacteria S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos YYD3_k127_6850028_6 379066.GAU_3070 2.461e-31 128.0 COG5531@1|root,COG5531@2|Bacteria,1ZTZP@142182|Gemmatimonadetes 142182|Gemmatimonadetes B SWI complex, BAF60b domains - - - - - - - - - - - - SWIB YYD3_k127_6850028_0 1379698.RBG1_1C00001G0614 1.826e-202 652.0 COG1505@1|root,COG1505@2|Bacteria,2NNUB@2323|unclassified Bacteria 2|Bacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N YYD3_k127_6850028_2 880073.Calab_3201 4.433e-131 430.0 COG4198@1|root,COG4198@2|Bacteria,2NNV0@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF1015) gdh - 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - - DUF1015 YYD3_k127_6850028_4 1123274.KB899430_gene1691 1.872e-92 312.0 COG0111@1|root,COG0111@2|Bacteria,2JA4I@203691|Spirochaetes 203691|Spirochaetes C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C YYD3_k127_6850028_1 1120985.AUMI01000011_gene435 1.035e-135 441.0 COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4H26T@909932|Negativicutes 909932|Negativicutes E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 YYD3_k127_6850028_7 439235.Dalk_0193 1.131e-11 66.0 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,42VWR@68525|delta/epsilon subdivisions,2WS4U@28221|Deltaproteobacteria,2MKU4@213118|Desulfobacterales 28221|Deltaproteobacteria P Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 YYD3_k127_6852_4 360910.BAV0092 1.801e-09 63.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2WERP@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyl transferase 4-like bplH - - - - - - - - - - - Glyco_trans_4_2,Glycos_transf_1 YYD3_k127_6852_3 1379698.RBG1_1C00001G0382 3.065e-13 81.0 COG5653@1|root,COG5653@2|Bacteria 2|Bacteria M Protein involved in cellulose biosynthesis - - - - - - - - - - - - Acetyltransf_6 YYD3_k127_6852_2 1250005.PHEL85_1929 1.023e-19 105.0 COG3292@1|root,COG3292@2|Bacteria,4NDWE@976|Bacteroidetes,1HY9S@117743|Flavobacteriia,3VW0M@52959|Polaribacter 976|Bacteroidetes T periplasmic ligand-binding sensor domain - - - - - - - - - - - - Reg_prop YYD3_k127_6852_1 1379698.RBG1_1C00001G0380 3.172e-71 258.0 COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria 2|Bacteria M Carbon-nitrogen hydrolase lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase YYD3_k127_6852_0 1321778.HMPREF1982_04157 1.999e-167 542.0 COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,267NF@186813|unclassified Clostridiales 186801|Clostridia G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N YYD3_k127_690492_5 497964.CfE428DRAFT_6370 1.144e-30 124.0 COG0370@1|root,COG0370@2|Bacteria,46SH4@74201|Verrucomicrobia 74201|Verrucomicrobia P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate YYD3_k127_690492_10 1042375.AFPL01000019_gene231 1.563e-12 70.0 COG1918@1|root,COG1918@2|Bacteria,1Q29C@1224|Proteobacteria,1TCA4@1236|Gammaproteobacteria,4694M@72275|Alteromonadaceae 1236|Gammaproteobacteria P FeoA - - - - - - - - - - - - FeoA YYD3_k127_690492_11 1121287.AUMU01000008_gene2029 1.979e-06 56.0 COG2010@1|root,COG2010@2|Bacteria,4NXZT@976|Bacteroidetes,1IBNZ@117743|Flavobacteriia,3ZS9T@59732|Chryseobacterium 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C,DHC YYD3_k127_690492_6 563192.HMPREF0179_03579 3.64e-26 114.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42SII@68525|delta/epsilon subdivisions,2WPJG@28221|Deltaproteobacteria,2MGU2@213115|Desulfovibrionales 28221|Deltaproteobacteria K Belongs to the Fur family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR YYD3_k127_690492_9 880073.Calab_0921 1.927e-19 104.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF4157,FctA,Peptidase_M43 YYD3_k127_690492_4 1231392.OCGS_1452 1.522e-60 238.0 COG4412@1|root,COG4412@2|Bacteria,1MWWV@1224|Proteobacteria,2U8R8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Immune inhibitor A peptidase M6 - - - - - - - - - - - - Peptidase_M6 YYD3_k127_690492_8 880073.Calab_0921 5.815e-21 109.0 COG1361@1|root,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - DUF4157,FctA,Peptidase_M43 YYD3_k127_690492_1 1379698.RBG1_1C00001G0069 2.109e-117 413.0 COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2NRP6@2323|unclassified Bacteria 2|Bacteria O Subtilase family - - - ko:K13276 - - - - ko00000,ko01000,ko01002,ko03110 - - - CHU_C,FlgD_ig,PKD,Peptidase_S8 YYD3_k127_690492_3 1379698.RBG1_1C00001G1816 1.101e-68 260.0 COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NR9R@2323|unclassified Bacteria 2|Bacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - DUF2723,PMT_2,TPR_8 YYD3_k127_690492_7 1379698.RBG1_1C00001G1817 5.1e-23 115.0 COG0308@1|root,COG0308@2|Bacteria,2NRIZ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase N - - - - - - - - - - - - CarbopepD_reg_2,Cofac_haem_bdg,NAAA-beta,Peptidase_M1,Phospholip_B YYD3_k127_690492_2 1379698.RBG1_1C00001G1818 1.56e-90 308.0 COG2067@1|root,COG2067@2|Bacteria,2NR34@2323|unclassified Bacteria 2|Bacteria I long-chain fatty acid transport protein - - - - - - - - - - - - - YYD3_k127_690492_0 1379698.RBG1_1C00001G1820 8.27e-162 539.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec YYD3_k127_697145_1 429009.Adeg_1290 1.054e-42 159.0 COG4401@1|root,COG4401@2|Bacteria,1VAID@1239|Firmicutes,24N1H@186801|Clostridia,42H1D@68295|Thermoanaerobacterales 186801|Clostridia E Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis aroH - 5.4.99.5 ko:K06208 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_1 YYD3_k127_697145_0 706587.Desti_1323 3.455e-130 424.0 COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria,2MRCR@213462|Syntrophobacterales 28221|Deltaproteobacteria H PFAM DAHP synthetase I aroG-2 - 2.5.1.54,5.4.99.5 ko:K03856,ko:K04516 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 YYD3_k127_697145_2 1385510.N781_17815 3.527e-09 61.0 COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,4HBI4@91061|Bacilli,2Y9K1@289201|Pontibacillus 91061|Bacilli E Prephenate dehydrogenase tyrA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU22610 ACT,PDH YYD3_k127_701443_2 1340493.JNIF01000003_gene4471 2.856e-09 58.0 COG2304@1|root,COG2304@2|Bacteria,3Y5S3@57723|Acidobacteria 57723|Acidobacteria S Vault protein inter-alpha-trypsin domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 YYD3_k127_701443_0 518766.Rmar_1542 1.052e-222 719.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,1FJ5H@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V YYD3_k127_701443_1 1379698.RBG1_1C00001G1136 1.393e-53 203.0 COG2956@1|root,COG2956@2|Bacteria 2|Bacteria G lipopolysaccharide metabolic process ciaB - - ko:K07502,ko:K08309,ko:K19804,ko:K21572 - - - - ko00000,ko01000,ko01011,ko02000 8.A.46.1,8.A.46.3 GH23 - SusD-like_3,SusD_RagB,TPR_16,TPR_6,TPR_8 YYD3_k127_704536_1 290317.Cpha266_2740 2.509e-54 202.0 COG0706@1|root,COG0706@2|Bacteria,1FDGH@1090|Chlorobi 1090|Chlorobi U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas YYD3_k127_704536_0 1304874.JAFY01000005_gene1178 1.078e-75 266.0 COG0486@1|root,COG0486@2|Bacteria,3TA4Z@508458|Synergistetes 508458|Synergistetes S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N YYD3_k127_705817_2 1144307.PMI04_00572 5.036e-14 78.0 COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,2TU7K@28211|Alphaproteobacteria,2K345@204457|Sphingomonadales 204457|Sphingomonadales F Phosphorylase superfamily - - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 YYD3_k127_705817_1 439235.Dalk_0201 5.655e-68 235.0 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42UR6@68525|delta/epsilon subdivisions,2WR1E@28221|Deltaproteobacteria,2MPYJ@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM Cytidine and deoxycytidylate deaminase zinc-binding region - - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 YYD3_k127_705817_0 795359.TOPB45_1257 2.145e-177 568.0 COG0174@1|root,COG0174@2|Bacteria,2GH5N@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N YYD3_k127_712213_2 1254432.SCE1572_26545 1.303e-27 124.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria,2Z0T8@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase YYD3_k127_712213_3 1280673.AUJJ01000018_gene987 1.256e-18 94.0 COG1011@1|root,COG1011@2|Bacteria,1TPBK@1239|Firmicutes,24EB9@186801|Clostridia,4BXT4@830|Butyrivibrio 186801|Clostridia L HAD-hyrolase-like - - - ko:K07025 - - - - ko00000 - - - HAD_2,NUDIX YYD3_k127_712213_0 1191523.MROS_2798 0.0 1230.0 COG0574@1|root,COG0574@2|Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_2,PPDK_N,Response_reg YYD3_k127_712213_1 378806.STAUR_7979 3.27e-41 157.0 2E2RY@1|root,32XUA@2|Bacteria,1N9C1@1224|Proteobacteria,42XP0@68525|delta/epsilon subdivisions,2WT7T@28221|Deltaproteobacteria,2YVJE@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF1579) - - - - - - - - - - - - DUF1579 YYD3_k127_712213_4 1191523.MROS_2800 8.011e-11 62.0 COG0334@1|root,COG0334@2|Bacteria 2|Bacteria E glutamate dehydrogenase [NAD(P)+] activity gluD GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN678.gdhA ELFV_dehydrog,ELFV_dehydrog_N YYD3_k127_713430_2 1379698.RBG1_1C00001G0207 3.543e-30 134.0 COG0457@1|root,COG0457@2|Bacteria 1379698.RBG1_1C00001G0207|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - YYD3_k127_713430_0 1379698.RBG1_1C00001G0649 7.762e-51 190.0 COG2045@1|root,COG2045@2|Bacteria,2NPF1@2323|unclassified Bacteria 2|Bacteria H Belongs to the ComB family comB GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp YYD3_k127_713430_1 1379698.RBG1_1C00001G0650 3.622e-47 173.0 COG0404@1|root,COG0404@2|Bacteria,2NNSR@2323|unclassified Bacteria 2|Bacteria E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C YYD3_k127_717161_2 1321781.HMPREF1985_00011 2.999e-08 59.0 COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4H4YZ@909932|Negativicutes 909932|Negativicutes CO Periplasmic protein thiol disulfide oxidoreductase, DsbE subfamily dsbE - - - - - - - - - - - AhpC-TSA,Redoxin YYD3_k127_717161_1 1124780.ANNU01000025_gene3419 5.296e-23 105.0 COG1331@1|root,COG1331@2|Bacteria,4PKPW@976|Bacteroidetes,47XYJ@768503|Cytophagia 976|Bacteroidetes O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH,Thioredoxin_2,Thioredoxin_7 YYD3_k127_717161_0 1379698.RBG1_1C00001G0460 3.9e-57 210.0 COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria 2|Bacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon YYD3_k127_738337_1 1499967.BAYZ01000182_gene4428 8.008e-41 154.0 COG0599@1|root,COG0599@2|Bacteria,2NRHA@2323|unclassified Bacteria 2|Bacteria O Carboxymuconolactone decarboxylase family rnhA - 3.1.26.4,4.1.1.44 ko:K01607,ko:K03469 ko00362,ko01100,ko01120,ko01220,ko03030,map00362,map01100,map01120,map01220,map03030 - R03470 RC00938 ko00000,ko00001,ko01000,ko03032 - - - CMD YYD3_k127_738337_0 522306.CAP2UW1_4252 1.42e-109 365.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2VXAW@28216|Betaproteobacteria 28216|Betaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,Radical_SAM YYD3_k127_765962_3 565655.ECBG_01342 8.097e-11 65.0 COG1853@1|root,COG1853@2|Bacteria,1V52S@1239|Firmicutes,4HGD9@91061|Bacilli,4B2A1@81852|Enterococcaceae 91061|Bacilli S Flavin reductase like domain ywrF - - - - - - - - - - - Flavin_Reduct YYD3_k127_765962_1 945713.IALB_1671 2.126e-131 428.0 COG0179@1|root,COG0179@2|Bacteria 2|Bacteria Q Fumarylacetoacetate (FAA) hydrolase fahA2 - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase YYD3_k127_765962_2 234267.Acid_4166 3.287e-96 327.0 COG0079@1|root,COG0079@2|Bacteria,3Y4H9@57723|Acidobacteria 57723|Acidobacteria E Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 YYD3_k127_765962_0 945713.IALB_1672 2.399e-156 499.0 COG3508@1|root,COG3508@2|Bacteria 2|Bacteria Q Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate hmgA - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA YYD3_k127_772215_2 1379698.RBG1_1C00001G0415 1.863e-62 224.0 COG5316@1|root,COG5316@2|Bacteria,2NPBR@2323|unclassified Bacteria 2|Bacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 YYD3_k127_772215_1 694427.Palpr_0129 1.615e-65 235.0 COG1562@1|root,COG1562@2|Bacteria 2|Bacteria I ergosterol biosynthetic process - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY YYD3_k127_772215_3 379066.GAU_1615 2.851e-41 167.0 COG0438@1|root,COG0438@2|Bacteria,1ZSTJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 YYD3_k127_772215_0 1379698.RBG1_1C00001G0707 6.557e-245 784.0 COG1197@1|root,COG1197@2|Bacteria,2NNMM@2323|unclassified Bacteria 2|Bacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - 2.4.1.129,3.4.16.4 ko:K03723,ko:K05365 ko00550,ko03420,map00550,map03420 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011,ko03400 - GT51 - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF YYD3_k127_774543_4 706587.Desti_2759 1.018e-20 96.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2MS08@213462|Syntrophobacterales 28221|Deltaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N YYD3_k127_774543_0 1379698.RBG1_1C00001G1061 1.759e-211 668.0 COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria 2|Bacteria C NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M YYD3_k127_774543_5 290397.Adeh_1557 3.488e-12 68.0 COG0695@1|root,COG0695@2|Bacteria,1P8SJ@1224|Proteobacteria,42XTX@68525|delta/epsilon subdivisions 1224|Proteobacteria O Glutaredoxin - - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin YYD3_k127_774543_2 398767.Glov_3125 3.629e-118 396.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M YYD3_k127_774543_1 1379698.RBG1_1C00001G1211 1.772e-188 599.0 COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria 2|Bacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iSB619.SA_RS05225 GATase_6,GATase_7,Pribosyltran YYD3_k127_805888_2 289376.THEYE_A0111 1.621e-38 146.0 COG0499@1|root,COG0499@2|Bacteria,3J0AH@40117|Nitrospirae 40117|Nitrospirae H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD YYD3_k127_805888_3 1410612.JNKO01000002_gene2447 2.892e-10 69.0 COG1309@1|root,COG1309@2|Bacteria,1V1C8@1239|Firmicutes,24FZ9@186801|Clostridia,2PTWS@265975|Oribacterium 186801|Clostridia K YsiA-like protein, C-terminal region - - - - - - - - - - - - TetR_C_4,TetR_N YYD3_k127_805888_0 311424.DhcVS_852 4.105e-191 602.0 COG1260@1|root,COG1260@2|Bacteria,2G5YH@200795|Chloroflexi,34CJX@301297|Dehalococcoidia 301297|Dehalococcoidia I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth YYD3_k127_81314_0 118168.MC7420_555 1.689e-206 660.0 COG0367@1|root,COG0367@2|Bacteria,1G1WZ@1117|Cyanobacteria,1H9W9@1150|Oscillatoriales 1117|Cyanobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 YYD3_k127_81314_1 880073.Calab_1595 4.543e-114 387.0 COG0318@1|root,COG0318@2|Bacteria,2NPH9@2323|unclassified Bacteria 2|Bacteria IQ COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C YYD3_k127_81314_3 344747.PM8797T_19627 3.324e-18 87.0 COG0236@1|root,COG0236@2|Bacteria,2J1MP@203682|Planctomycetes 203682|Planctomycetes IQ acyl carrier protein - - - - - - - - - - - - PP-binding YYD3_k127_81314_2 880073.Calab_3144 1.354e-72 250.0 COG0171@1|root,COG0171@2|Bacteria 2|Bacteria H NAD+ synthase (glutamine-hydrolyzing) activity nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase YYD3_k127_816966_1 1379698.RBG1_1C00001G1257 9.464e-37 147.0 COG3166@1|root,COG3166@2|Bacteria 2|Bacteria NU PFAM Fimbrial assembly family protein pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN YYD3_k127_816966_0 1379698.RBG1_1C00001G1258 7.753e-149 482.0 COG4972@1|root,COG4972@2|Bacteria,2NPF6@2323|unclassified Bacteria 2|Bacteria NU Type IV pilus assembly protein PilM; pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 YYD3_k127_816966_2 1379698.RBG1_1C00001G1259 4.458e-09 62.0 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl YYD3_k127_822020_2 671143.DAMO_0010 6.74e-71 249.0 COG0483@1|root,COG0483@2|Bacteria,2NP94@2323|unclassified Bacteria 2|Bacteria G Inositol monophosphatase suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P YYD3_k127_822020_0 1191523.MROS_1555 8.78e-192 616.0 COG1132@1|root,COG1132@2|Bacteria 2|Bacteria V (ABC) transporter MdlB - - ko:K06147,ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran YYD3_k127_822020_1 525904.Tter_1166 1.949e-76 262.0 COG1132@1|root,COG1132@2|Bacteria,2NNN4@2323|unclassified Bacteria 2|Bacteria V ABC transporter transmembrane region mdlA - - ko:K06147,ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran YYD3_k127_823988_3 1379698.RBG1_1C00001G0445 3.087e-28 116.0 COG0542@1|root,COG0542@2|Bacteria,2NNKN@2323|unclassified Bacteria 2|Bacteria O C-terminal, D2-small domain, of ClpB protein clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR YYD3_k127_823988_1 1305836.AXVE01000011_gene1038 2.915e-33 132.0 2AEMC@1|root,314H9@2|Bacteria,1W0UA@1239|Firmicutes,4HRRY@91061|Bacilli 91061|Bacilli S Protein of unknown function (DUF1761) - - - - - - - - - - - - DUF1761 YYD3_k127_823988_2 378806.STAUR_2272 2.724e-30 121.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2WQ2U@28221|Deltaproteobacteria,2YVJI@29|Myxococcales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 YYD3_k127_823988_0 886293.Sinac_1729 6.481e-69 251.0 COG0501@1|root,COG0501@2|Bacteria,2J0GY@203682|Planctomycetes 203682|Planctomycetes O CAAX prenyl protease N-terminal, five membrane helices - - - - - - - - - - - - Peptidase_M48,Peptidase_M48_N YYD3_k127_823988_4 1379698.RBG1_1C00001G0290 9.232e-27 126.0 COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria 2|Bacteria E aminopeptidase - - - - - - - - - - - - BPD_transp_1,PD40,Peptidase_M1 YYD3_k127_831992_1 1131269.AQVV01000022_gene2229 1.347e-38 164.0 COG1344@1|root,COG1344@2|Bacteria 2|Bacteria N bacterial-type flagellum-dependent cell motility flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N YYD3_k127_831992_3 641107.CDLVIII_5022 5.97e-25 110.0 COG1699@1|root,COG1699@2|Bacteria,1VA6Y@1239|Firmicutes,24QXE@186801|Clostridia,36JMK@31979|Clostridiaceae 186801|Clostridia S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW YYD3_k127_831992_0 237368.SCABRO_02315 2.977e-61 240.0 COG0457@1|root,COG0463@1|root,COG0457@2|Bacteria,COG0463@2|Bacteria,2J07E@203682|Planctomycetes 203682|Planctomycetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_trans_1_2,Glycos_transf_2,Methyltransf_23,TPR_16,TPR_19,TPR_7,TPR_8 YYD3_k127_831992_2 1210884.HG799473_gene15053 2.315e-31 127.0 COG1344@1|root,COG1344@2|Bacteria,2IX6G@203682|Planctomycetes 203682|Planctomycetes N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella fliC - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N YYD3_k127_869817_5 1379698.RBG1_1C00001G1213 3.896e-27 113.0 COG1956@1|root,COG1956@2|Bacteria,2NPKF@2323|unclassified Bacteria 2|Bacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. yebR - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 YYD3_k127_869817_1 1379698.RBG1_1C00001G1216 7.686e-97 330.0 COG0407@1|root,COG0407@2|Bacteria,2NPIC@2323|unclassified Bacteria 2|Bacteria H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D YYD3_k127_869817_2 1307436.PBF_09932 1.551e-89 302.0 COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,4HFED@91061|Bacilli,1ZAXA@1386|Bacillus 91061|Bacilli S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 YYD3_k127_869817_0 1379698.RBG1_1C00001G1210 2.377e-171 549.0 COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria 2|Bacteria T Two component, sigma54 specific, transcriptional regulator, Fis family nla19 - - ko:K02667,ko:K07713,ko:K07714,ko:K19641 ko02020,map02020 M00499,M00500,M00501,M00772 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_869817_4 1379698.RBG1_1C00001G1208 1.132e-29 126.0 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion mshB - - ko:K02456,ko:K02650,ko:K10924,ko:K10925 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - N_methyl,Pilin,T2SSG YYD3_k127_869817_3 1379698.RBG1_1C00001G1208 7.812e-39 149.0 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion mshB - - ko:K02456,ko:K02650,ko:K10924,ko:K10925 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - N_methyl,Pilin,T2SSG YYD3_k127_869817_7 997346.HMPREF9374_1390 7.539e-14 82.0 COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,4HBB4@91061|Bacilli,27B73@186824|Thermoactinomycetaceae 91061|Bacilli L DNA polymerase III, delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta YYD3_k127_87460_0 1379698.RBG1_1C00001G0830 3.442e-111 372.0 COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria 2|Bacteria J elongation factor G fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 YYD3_k127_87460_2 1174504.AJTN02000214_gene2464 1.999e-48 181.0 COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,4HFXF@91061|Bacilli,1ZCU9@1386|Bacillus 91061|Bacilli S Belongs to the UPF0312 family - - - - - - - - - - - - YceI YYD3_k127_87460_3 694427.Palpr_2946 1.59e-27 116.0 2BFHQ@1|root,329BH@2|Bacteria,4P73M@976|Bacteroidetes,2FZWT@200643|Bacteroidia 976|Bacteroidetes - - - - - - - - - - - - - - - YYD3_k127_87460_1 498211.CJA_2994 2.393e-68 237.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1FFXM@10|Cellvibrio 1236|Gammaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind YYD3_k127_87460_4 1449346.JQMO01000002_gene173 3.878e-16 81.0 COG1917@1|root,COG1917@2|Bacteria,2IQ74@201174|Actinobacteria 201174|Actinobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - YYD3_k127_877771_0 1379698.RBG1_1C00001G0551 5.13e-153 497.0 COG1508@1|root,COG1508@2|Bacteria,2NNZA@2323|unclassified Bacteria 2|Bacteria K RNA polymerase sigma-54 factor rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD YYD3_k127_877771_1 1379698.RBG1_1C00001G0552 5.736e-17 87.0 COG1544@1|root,COG1544@2|Bacteria 2|Bacteria J regulation of translation hpf GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006446,GO:0006448,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808,ko:K05809 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE YYD3_k127_878934_2 1047013.AQSP01000105_gene1453 9.685e-07 50.0 COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria 2|Bacteria C Electron transfer flavoprotein fixB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 ko:K03522,ko:K22432 - - - - ko00000,ko01000,ko04147 - - iAF987.Gmet_2066,iAF987.Gmet_2257 ETF,ETF_alpha,Fer4 YYD3_k127_878934_1 269797.Mbar_A1802 4.709e-19 101.0 COG1520@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02482@2157|Archaea,arCOG02550@2157|Archaea,arCOG03991@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKV@224756|Methanomicrobia 224756|Methanomicrobia G PQQ-like domain - - - - - - - - - - - - NosD,PKD,PQQ_2,PQQ_3 YYD3_k127_878934_0 552811.Dehly_0442 2.197e-26 124.0 COG3303@1|root,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Cytochrom_c3_2 YYD3_k127_878934_3 35754.JNYJ01000009_gene1967 0.0002492 54.0 2B2RC@1|root,31VBF@2|Bacteria,2HWQJ@201174|Actinobacteria,4DJYJ@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - YYD3_k127_899326_2 945713.IALB_0725 3.668e-17 84.0 COG5456@1|root,COG5456@2|Bacteria 2|Bacteria P FixH fixH - - - - - - - - - - - FixH YYD3_k127_899326_1 945713.IALB_0726 2.691e-56 206.0 COG2836@1|root,COG2836@2|Bacteria 2|Bacteria K Biogenesis protein braZ - - ko:K09792 - - - - ko00000 - - - DsbD_2,Ferric_reduct YYD3_k127_899326_0 945713.IALB_2739 9.083e-143 456.0 COG0114@1|root,COG0114@2|Bacteria 2|Bacteria C fumarate hydratase activity fumC GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 YYD3_k127_904733_9 102125.Xen7305DRAFT_00054230 5.332e-05 54.0 COG2931@1|root,COG2931@2|Bacteria,1GQMR@1117|Cyanobacteria,3VMWP@52604|Pleurocapsales 2|Bacteria Q PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Beta_helix,FG-GAP,HCBP_related,HemolysinCabind YYD3_k127_904733_3 1379698.RBG1_1C00001G0179 1.327e-82 295.0 COG0065@1|root,COG0065@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity - - 4.2.1.33,4.2.1.35,4.2.1.36 ko:K01703,ko:K01705 ko00290,ko00300,ko00660,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00966,map01100,map01110,map01120,map01130,map01210,map01230 M00030,M00432,M00433,M00535 R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C YYD3_k127_904733_6 1379698.RBG1_1C00001G0180 4.914e-52 189.0 COG0537@1|root,COG0537@2|Bacteria,2NPE0@2323|unclassified Bacteria 2|Bacteria FG HIT domain hit GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - HIT YYD3_k127_904733_4 457570.Nther_2188 1.85e-80 291.0 COG4805@1|root,COG4805@2|Bacteria 2|Bacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 YYD3_k127_904733_0 1379698.RBG1_1C00001G0178 3.619e-115 387.0 COG2265@1|root,COG2265@2|Bacteria,2NNWX@2323|unclassified Bacteria 2|Bacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr YYD3_k127_904733_5 521045.Kole_0424 7.022e-58 213.0 COG1230@1|root,COG1230@2|Bacteria,2GCWV@200918|Thermotogae 200918|Thermotogae P cation diffusion facilitator family transporter - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux,ZT_dimer YYD3_k127_904733_2 269799.Gmet_1153 1.075e-87 305.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WKVE@28221|Deltaproteobacteria,43S28@69541|Desulfuromonadales 28221|Deltaproteobacteria P CBS domain containing protein - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 YYD3_k127_904733_1 56780.SYN_03628 9.582e-99 330.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MQ6Z@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 YYD3_k127_904733_8 1265313.HRUBRA_00444 3.881e-07 63.0 COG3633@1|root,COG3633@2|Bacteria,1MXE1@1224|Proteobacteria,1RP9B@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) sstT GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 - ko:K07862 - - - - ko00000,ko02000 2.A.23.4 - iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iYL1228.KPN_03517,iZ_1308.Z4442 SDF YYD3_k127_904733_7 278957.ABEA03000120_gene1234 6.352e-11 68.0 COG5652@1|root,COG5652@2|Bacteria,46WK5@74201|Verrucomicrobia,3K8DM@414999|Opitutae 414999|Opitutae S VanZ like family - - - - - - - - - - - - VanZ YYD3_k127_908304_0 945713.IALB_1673 3.969e-155 497.0 COG3185@1|root,COG3185@2|Bacteria 2|Bacteria E 4-Hydroxyphenylpyruvate dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 YYD3_k127_908304_1 468059.AUHA01000002_gene43 1.951e-121 396.0 COG3186@1|root,COG3186@2|Bacteria,4NEX5@976|Bacteroidetes,1IQDN@117747|Sphingobacteriia 976|Bacteroidetes E Biopterin-dependent aromatic amino acid hydroxylase phhA - 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 - R01795,R07211 RC00490 ko00000,ko00001,ko01000 - - - Biopterin_H YYD3_k127_921882_1 1173028.ANKO01000161_gene5040 4.204e-56 226.0 COG2202@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1GHCI@1117|Cyanobacteria,1HARB@1150|Oscillatoriales 1117|Cyanobacteria T His Kinase A (phosphoacceptor) domain - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF,GGDEF,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9 YYD3_k127_921882_0 289376.THEYE_A1377 2.136e-86 302.0 COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae 40117|Nitrospirae T Bacterial regulatory protein, Fis family - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat YYD3_k127_921882_2 1354300.AUQY01000002_gene873 3.381e-12 73.0 COG1716@1|root,COG1716@2|Bacteria,1VF0E@1239|Firmicutes,24PKU@186801|Clostridia,22H5Z@1570339|Peptoniphilaceae 186801|Clostridia T FHA domain protein - - - - - - - - - - - - FHA YYD3_k127_969170_17 102129.Lepto7375DRAFT_3697 1.718e-34 133.0 COG0099@1|root,COG0099@2|Bacteria,1G5S9@1117|Cyanobacteria,1HB1Z@1150|Oscillatoriales 1117|Cyanobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 YYD3_k127_969170_27 660470.Theba_0701 6.002e-12 65.0 COG0257@1|root,COG0257@2|Bacteria,2GDKI@200918|Thermotogae 200918|Thermotogae J Belongs to the bacterial ribosomal protein bL36 family rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 YYD3_k127_969170_15 1379698.RBG1_1C00001G1573 9.694e-38 143.0 COG0361@1|root,COG0361@2|Bacteria,2NPNU@2323|unclassified Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a YYD3_k127_969170_3 1069080.KB913028_gene492 4.91e-93 311.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,4H2VZ@909932|Negativicutes 909932|Negativicutes E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 YYD3_k127_969170_7 644966.Tmar_2275 1.436e-64 231.0 COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,3WCG7@538999|Clostridiales incertae sedis 186801|Clostridia F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS20110 ADK,ADK_lid YYD3_k127_969170_0 1379698.RBG1_1C00001G1576 4.213e-186 593.0 COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria 2|Bacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY YYD3_k127_969170_13 1379698.RBG1_1C00001G1577 7.691e-44 164.0 COG0200@1|root,COG0200@2|Bacteria,2NPNV@2323|unclassified Bacteria 2|Bacteria J Binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A YYD3_k127_969170_23 945713.IALB_0930 4.062e-17 83.0 COG1841@1|root,COG1841@2|Bacteria 2|Bacteria J maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 YYD3_k127_969170_10 1304885.AUEY01000001_gene3231 1.04e-52 190.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C YYD3_k127_969170_18 290397.Adeh_1930 1.628e-28 118.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,42TIT@68525|delta/epsilon subdivisions,2WQ8U@28221|Deltaproteobacteria,2YVEW@29|Myxococcales 28221|Deltaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p YYD3_k127_969170_9 1121104.AQXH01000010_gene2432 3.862e-60 215.0 COG0097@1|root,COG0097@2|Bacteria,4NGJM@976|Bacteroidetes,1IRC9@117747|Sphingobacteriia 976|Bacteroidetes J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 YYD3_k127_969170_16 941770.GL622181_gene891 1.143e-35 139.0 COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,4HH32@91061|Bacilli,3F64E@33958|Lactobacillaceae 91061|Bacilli J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 YYD3_k127_969170_21 59374.Fisuc_1409 1.71e-24 103.0 COG0199@1|root,COG0199@2|Bacteria 2|Bacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 YYD3_k127_969170_4 1121422.AUMW01000023_gene2774 2.108e-77 263.0 COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,2603I@186807|Peptococcaceae 186801|Clostridia J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C YYD3_k127_969170_19 1408254.T458_24835 1.89e-28 117.0 COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,4HKH9@91061|Bacilli,26XQC@186822|Paenibacillaceae 91061|Bacilli J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 YYD3_k127_969170_11 1379698.RBG1_1C00001G1586 1.078e-51 188.0 COG0093@1|root,COG0093@2|Bacteria,2NPCS@2323|unclassified Bacteria 2|Bacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 YYD3_k127_969170_20 518766.Rmar_0851 1.634e-27 113.0 COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,1FJGB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 YYD3_k127_969170_26 1379698.RBG1_1C00001G1588 7.432e-15 77.0 COG0255@1|root,COG0255@2|Bacteria,2NQ49@2323|unclassified Bacteria 2|Bacteria J Ribosomal L29 protein rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 YYD3_k127_969170_6 221288.JH992901_gene949 7.771e-66 226.0 COG0197@1|root,COG0197@2|Bacteria,1G55B@1117|Cyanobacteria,1JIH0@1189|Stigonemataceae 1117|Cyanobacteria J Ribosomal protein L16p/L10e rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 YYD3_k127_969170_2 1379698.RBG1_1C00001G1590 3.577e-93 314.0 COG0092@1|root,COG0092@2|Bacteria,2NP6J@2323|unclassified Bacteria 2|Bacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C YYD3_k127_969170_22 557599.MKAN_19660 2.177e-24 108.0 COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,238NP@1762|Mycobacteriaceae 201174|Actinobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 YYD3_k127_969170_14 1379698.RBG1_1C00001G1592 2.051e-43 159.0 COG0185@1|root,COG0185@2|Bacteria,2NPIV@2323|unclassified Bacteria 2|Bacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 YYD3_k127_969170_1 335543.Sfum_1558 2.727e-116 380.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,42MBV@68525|delta/epsilon subdivisions,2WIRE@28221|Deltaproteobacteria,2MR4Z@213462|Syntrophobacterales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C YYD3_k127_969170_25 1265505.ATUG01000001_gene3707 4.418e-16 81.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,42V3Y@68525|delta/epsilon subdivisions,2WRMX@28221|Deltaproteobacteria,2MKJ3@213118|Desulfobacterales 28221|Deltaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 YYD3_k127_969170_8 1297581.H919_09051 1.169e-60 215.0 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4HB01@91061|Bacilli,21WMU@150247|Anoxybacillus 91061|Bacilli J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 YYD3_k127_969170_5 1379698.RBG1_1C00001G1596 8.697e-67 234.0 COG0087@1|root,COG0087@2|Bacteria,2NPAI@2323|unclassified Bacteria 2|Bacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 YYD3_k127_969170_12 1379698.RBG1_1C00001G1598 2.078e-44 162.0 COG0051@1|root,COG0051@2|Bacteria,2NPJY@2323|unclassified Bacteria 2|Bacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 YYD3_k127_969170_24 1379281.AVAG01000108_gene241 2.969e-16 78.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2M88A@213115|Desulfovibrionales 28221|Deltaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 YYD3_k127_98398_0 1379698.RBG1_1C00001G1649 1.069e-172 548.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,2NNYX@2323|unclassified Bacteria 2|Bacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K02535,ko:K13599,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,ko02020,map00061,map00540,map00780,map01100,map01212,map02020 M00060,M00083,M00498,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005,ko02022 - - - FabA,LpxC YYD3_k127_98398_2 1379698.RBG1_1C00001G1648 5.163e-99 329.0 COG1043@1|root,COG1043@2|Bacteria,2NP5V@2323|unclassified Bacteria 2|Bacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep YYD3_k127_98398_3 411154.GFO_0667 6.725e-80 278.0 COG0673@1|root,COG0673@2|Bacteria,4NEC6@976|Bacteroidetes,1HXSP@117743|Flavobacteriia 976|Bacteroidetes S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA YYD3_k127_98398_4 933262.AXAM01000069_gene2694 2.69e-69 248.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MIFD@213118|Desulfobacterales 28221|Deltaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB YYD3_k127_98398_5 1121943.KB899996_gene590 8.548e-61 225.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1XHB6@135619|Oceanospirillales 135619|Oceanospirillales M transferase waaA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N YYD3_k127_98398_7 936589.HMPREF1521_1439 6.324e-39 159.0 COG1663@1|root,COG1663@2|Bacteria,1TWGA@1239|Firmicutes,4H97G@909932|Negativicutes 909932|Negativicutes M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Glycos_transf_N,LpxK YYD3_k127_98398_1 1379698.RBG1_1C00001G1642 6.699e-162 526.0 COG0029@1|root,COG0029@2|Bacteria,2NNMD@2323|unclassified Bacteria 2|Bacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.3.5.4,1.4.3.16 ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899 FAD_binding_2,Succ_DH_flav_C YYD3_k127_98398_6 1527444.ucyna2_00961 2.392e-45 168.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1G06N@1117|Cyanobacteria 1117|Cyanobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase ## 2352 queries scanned ## Total time (seconds): 5.675346612930298 ## Rate: 414.42 q/s