## Sat Dec 13 18:15:39 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/SRR25158203_bin.5.fa -m mmseqs --itype genome -o SRR25158203_bin.5 --output_dir /data/result/bins/wyx/egg/SRR25158203_bin.5 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SRR25158203_k127_10371_2	426355.Mrad2831_4146	8.16e-34	135.0	COG2357@1|root,COG2357@2|Bacteria,1RDE9@1224|Proteobacteria,2UHFA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Region found in RelA / SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	RelA_SpoT
SRR25158203_k127_10371_4	192952.MM_0201	7.264e-06	52.0	arCOG05051@1|root,arCOG05051@2157|Archaea,2Y15G@28890|Euryarchaeota,2NBF6@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
SRR25158203_k127_10371_0	1094980.Mpsy_2683	6.324e-227	712.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
SRR25158203_k127_10371_1	5888.CAK86787	8.261e-82	282.0	COG3914@1|root,KOG4626@2759|Eukaryota	2759|Eukaryota	O	protein N-acetylglucosaminyltransferase activity	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
SRR25158203_k127_10371_3	391623.TERMP_01244	3.027e-14	75.0	arCOG04797@1|root,arCOG04797@2157|Archaea,2XZMY@28890|Euryarchaeota,24531@183968|Thermococci	183968|Thermococci	S	retrograde transport, endosome to Golgi	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1049494_1	351160.RCIX1748	4.652e-32	125.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,2N94B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
SRR25158203_k127_1049494_0	555088.DealDRAFT_0595	2.255e-207	659.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,42KZ0@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SRR25158203_k127_1075159_8	1392493.JIAB01000001_gene150	5.494e-05	51.0	COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,25C3N@186801|Clostridia,27IQN@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Phage integrase family	xerS	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
SRR25158203_k127_1075159_3	192952.MM_1981	2.206e-43	163.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,2NB08@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM molydopterin dinucleotide-binding region	fwdD-1	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
SRR25158203_k127_1075159_1	192952.MM_1980	2.362e-175	559.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,2NACR@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	fwdB-1	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
SRR25158203_k127_1075159_0	192952.MM_1979	6.131e-218	689.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,2N9G0@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
SRR25158203_k127_1075159_2	192952.MM_1978	6.047e-96	319.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,2NAVQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM glutamate synthase alpha subunit domain protein	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
SRR25158203_k127_1075159_5	693661.Arcve_1845	6.501e-22	106.0	COG0681@1|root,arCOG05454@1|root,arCOG01740@2157|Archaea,arCOG05454@2157|Archaea,2XY8G@28890|Euryarchaeota,246AH@183980|Archaeoglobi	183980|Archaeoglobi	U	PFAM Peptidase S24 S26A S26B, conserved region	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
SRR25158203_k127_1075159_7	693661.Arcve_1844	4.881e-17	94.0	arCOG13399@1|root,arCOG13399@2157|Archaea,2XY6J@28890|Euryarchaeota,246C9@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1075159_4	1094980.Mpsy_0105	4.624e-22	112.0	arCOG03269@1|root,arCOG03269@2157|Archaea,2Y2NU@28890|Euryarchaeota,2NAPV@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SRR25158203_k127_1075159_6	565033.GACE_1360	3.843e-19	94.0	arCOG09418@1|root,arCOG09418@2157|Archaea,2Y0JZ@28890|Euryarchaeota,246GY@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2
SRR25158203_k127_1110997_3	1094508.Tsac_0605	2.052e-36	143.0	COG1533@1|root,COG1533@2|Bacteria,1TQA6@1239|Firmicutes,24A2T@186801|Clostridia,42F9K@68295|Thermoanaerobacterales	186801|Clostridia	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
SRR25158203_k127_1110997_4	1201293.AKXQ01000008_gene714	1.157e-33	139.0	2DDZV@1|root,32U2A@2|Bacteria,1MZU0@1224|Proteobacteria,1SQ2I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1110997_2	1041930.Mtc_1253	2.337e-40	151.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,2NA1A@224756|Methanomicrobia	224756|Methanomicrobia	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	-	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
SRR25158203_k127_1110997_0	304371.MCP_1531	1.019e-83	285.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
SRR25158203_k127_1110997_1	1094980.Mpsy_1475	1.561e-59	211.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,2N9JJ@224756|Methanomicrobia	224756|Methanomicrobia	J	KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
SRR25158203_k127_1110997_5	868131.MSWAN_0269	1.357e-14	84.0	arCOG02499@1|root,arCOG02499@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD
SRR25158203_k127_1116991_8	211586.SO_3858	3.789e-07	51.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,2QDSH@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
SRR25158203_k127_1116991_2	680198.SCAB_23781	3.744e-35	140.0	2C1AE@1|root,32QZN@2|Bacteria,2IIC0@201174|Actinobacteria	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
SRR25158203_k127_1116991_1	517417.Cpar_0066	1.415e-58	209.0	COG0778@1|root,COG0778@2|Bacteria,1FEBI@1090|Chlorobi	1090|Chlorobi	C	PFAM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRR25158203_k127_1116991_6	1121481.AUAS01000004_gene1539	1.051e-13	76.0	COG0346@1|root,COG0346@2|Bacteria,4NQ7X@976|Bacteroidetes,47QHB@768503|Cytophagia	976|Bacteroidetes	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	gloA	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
SRR25158203_k127_1116991_7	1121405.dsmv_0196	1.195e-07	60.0	COG0426@1|root,COG0426@2|Bacteria,1N47N@1224|Proteobacteria,42UNB@68525|delta/epsilon subdivisions,2WQA6@28221|Deltaproteobacteria,2MQ13@213118|Desulfobacterales	28221|Deltaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
SRR25158203_k127_1116991_0	1229909.NSED_06385	8.873e-145	468.0	COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
SRR25158203_k127_1116991_5	1463885.KL578395_gene9091	2.784e-14	81.0	2DDCG@1|root,2ZHHT@2|Bacteria,2IR2X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1116991_3	868131.MSWAN_0985	5.076e-26	109.0	COG2329@1|root,arCOG05403@2157|Archaea,2Y22C@28890|Euryarchaeota	28890|Euryarchaeota	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
SRR25158203_k127_112769_9	525904.Tter_1874	3.693e-48	198.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_23,Rad50_zn_hook,SMC_N
SRR25158203_k127_112769_2	304371.MCP_1421	4.686e-89	306.0	COG1630@1|root,arCOG00367@2157|Archaea,2XW4V@28890|Euryarchaeota	28890|Euryarchaeota	L	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
SRR25158203_k127_112769_10	1041930.Mtc_1783	4.619e-26	113.0	arCOG11119@1|root,arCOG11119@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_112769_0	304371.MCP_1417	1.453e-173	559.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,2NBG2@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
SRR25158203_k127_112769_6	456442.Mboo_0111	1.45e-56	201.0	COG0817@1|root,arCOG06910@2157|Archaea,2Y49H@28890|Euryarchaeota,2NB1G@224756|Methanomicrobia	224756|Methanomicrobia	L	Crossover junction endodeoxyribonuclease RuvC	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
SRR25158203_k127_112769_1	1094980.Mpsy_2900	3.132e-96	321.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,2N9MI@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
SRR25158203_k127_112769_4	192952.MM_2783	1.031e-73	257.0	COG0483@1|root,arCOG01349@2157|Archaea,2XUBB@28890|Euryarchaeota,2N9NZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SRR25158203_k127_112769_12	192952.MM_2583	4.82e-17	84.0	COG1826@1|root,arCOG02694@2157|Archaea,2XZZ6@28890|Euryarchaeota,2NB5U@224756|Methanomicrobia	224756|Methanomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SRR25158203_k127_112769_11	387631.Asulf_01670	9.273e-20	92.0	COG1826@1|root,arCOG02694@2157|Archaea,2XZZ6@28890|Euryarchaeota,246CG@183980|Archaeoglobi	183980|Archaeoglobi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SRR25158203_k127_112769_8	1094980.Mpsy_2166	6.318e-54	192.0	arCOG03354@1|root,arCOG03353@2157|Archaea,2Y3N8@28890|Euryarchaeota,2NAX4@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1699)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1699
SRR25158203_k127_112769_3	192952.MM_1616	1.165e-83	284.0	COG1691@1|root,arCOG02465@2157|Archaea,2XTIH@28890|Euryarchaeota,2N9MD@224756|Methanomicrobia	224756|Methanomicrobia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
SRR25158203_k127_112769_7	269797.Mbar_A1293	3.081e-55	202.0	COG2968@1|root,arCOG04715@2157|Archaea,2XZAZ@28890|Euryarchaeota,2N9TF@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
SRR25158203_k127_112769_5	1122611.KB903952_gene5999	8.029e-65	231.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria,4EMQF@85012|Streptosporangiales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR25158203_k127_1138396_8	1094980.Mpsy_1331	2.618e-14	78.0	COG3937@1|root,arCOG04978@2157|Archaea,2Y5CQ@28890|Euryarchaeota,2NBBZ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1138396_2	1094980.Mpsy_1320	2.469e-136	452.0	COG0661@1|root,arCOG01189@2157|Archaea,2XT2I@28890|Euryarchaeota,2N9FG@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM ABC-1 domain protein	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
SRR25158203_k127_1138396_6	443143.GM18_3755	9.484e-49	182.0	COG0775@1|root,COG0775@2|Bacteria,1NDXU@1224|Proteobacteria,42TU4@68525|delta/epsilon subdivisions,2WQX3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnB	-	3.2.2.26	ko:K11783	ko00130,ko01110,map00130,map01110	-	R08587	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
SRR25158203_k127_1138396_4	1232410.KI421417_gene2744	8.922e-99	329.0	COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2WIMS@28221|Deltaproteobacteria,43TEZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
SRR25158203_k127_1138396_5	1094980.Mpsy_1821	8.668e-80	270.0	COG0299@1|root,arCOG02825@2157|Archaea,2Y838@28890|Euryarchaeota,2N9JE@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM formyl transferase domain protein	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2317	Formyl_trans_N
SRR25158203_k127_1138396_0	1094980.Mpsy_1820	2.413e-188	595.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,2N90U@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SRR25158203_k127_1138396_3	1094980.Mpsy_1819	3.903e-112	368.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,2N9EP@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
SRR25158203_k127_1138396_1	304371.MCP_0624	2.473e-144	464.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,2N915@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
SRR25158203_k127_1138396_7	269797.Mbar_A2369	3.245e-21	94.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y4NR@28890|Euryarchaeota,2NB66@224756|Methanomicrobia	224756|Methanomicrobia	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SRR25158203_k127_1138396_10	269797.Mbar_A2369	0.0001561	44.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y4NR@28890|Euryarchaeota,2NB66@224756|Methanomicrobia	224756|Methanomicrobia	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SRR25158203_k127_1138396_9	1487953.JMKF01000006_gene5668	1.168e-05	51.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,1HA72@1150|Oscillatoriales	1117|Cyanobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRR25158203_k127_1142929_7	693661.Arcve_0178	0.0006171	45.0	COG3316@1|root,arCOG02134@2157|Archaea,2XUAY@28890|Euryarchaeota	28890|Euryarchaeota	L	COG3316 Transposase and inactivated derivatives	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240,HTH_23
SRR25158203_k127_1142929_1	1094980.Mpsy_2381	1.46e-78	274.0	COG0628@1|root,arCOG02642@2157|Archaea,2XXF0@28890|Euryarchaeota,2N9N3@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SRR25158203_k127_1142929_0	269797.Mbar_A2696	1.268e-204	646.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRR25158203_k127_1142929_5	760568.Desku_3249	2.832e-10	65.0	COG2009@1|root,COG2009@2|Bacteria,1VKGI@1239|Firmicutes,24VB1@186801|Clostridia	186801|Clostridia	C	TIGRFAM Succinate dehydrogenase, cytochrome b556 subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
SRR25158203_k127_1142929_3	386456.JQKN01000011_gene731	8.163e-59	212.0	COG0479@1|root,arCOG00962@2157|Archaea,2XSXW@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
SRR25158203_k127_1142929_4	351160.RCIX895	3.146e-35	142.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,2NB7U@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1142929_6	1041930.Mtc_1297	2.997e-05	47.0	arCOG10686@1|root,arCOG10686@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
SRR25158203_k127_1142929_2	710696.Intca_0367	1.101e-71	249.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FGKI@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
SRR25158203_k127_1175872_11	323259.Mhun_3126	1.165e-10	76.0	arCOG02516@1|root,arCOG03509@1|root,arCOG02516@2157|Archaea,arCOG03509@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF2341)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CHB_HEX_C_1,DUF2341,PEGA,PKD,PQQ_3
SRR25158203_k127_1175872_9	269797.Mbar_A1626	1.08e-15	92.0	COG1404@1|root,arCOG02512@1|root,arCOG00702@2157|Archaea,arCOG02512@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
SRR25158203_k127_1175872_5	877455.Metbo_0857	6.63e-56	200.0	COG0438@1|root,arCOG01403@2157|Archaea,2XYXB@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SRR25158203_k127_1175872_6	1232410.KI421421_gene3385	2.173e-27	118.0	COG0438@1|root,COG0438@2|Bacteria,1RCC7@1224|Proteobacteria,42YR8@68525|delta/epsilon subdivisions,2WTJB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1175872_4	925409.KI911562_gene150	6.416e-89	303.0	COG2227@1|root,COG2227@2|Bacteria,4NNQC@976|Bacteroidetes	976|Bacteroidetes	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR25158203_k127_1175872_0	386456.JQKN01000005_gene519	3.664e-190	611.0	COG0367@1|root,arCOG00071@2157|Archaea,2XV5E@28890|Euryarchaeota	28890|Euryarchaeota	E	Asparagine synthase, glutamine-hydrolyzing	asnB-1	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
SRR25158203_k127_1175872_10	877455.Metbo_1314	2.846e-15	88.0	COG0438@1|root,arCOG01408@2157|Archaea,2XXWP@28890|Euryarchaeota,23PFU@183925|Methanobacteria	183925|Methanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SRR25158203_k127_1175872_8	1220534.B655_2035	4.817e-22	104.0	COG0500@1|root,arCOG01773@2157|Archaea,2Y131@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
SRR25158203_k127_1175872_3	351160.LRC544	5.179e-108	362.0	COG0438@1|root,arCOG01403@2157|Archaea,2Y8BE@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_1175872_7	926560.KE387023_gene1297	1.492e-22	111.0	COG0675@1|root,COG0675@2|Bacteria,1WJP1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	TIGRFAM transposase, IS605 OrfB family, central region	-	-	-	-	-	-	-	-	-	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
SRR25158203_k127_1175872_2	192952.MM_0649	8.134e-137	444.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUVC@28890|Euryarchaeota,2NAMI@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_1175872_1	269797.Mbar_A0241	6.627e-162	518.0	COG0438@1|root,arCOG01415@2157|Archaea,2XUVW@28890|Euryarchaeota,2N932@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_1179017_2	1094980.Mpsy_2174	8.975e-72	245.0	COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,2N9NF@224756|Methanomicrobia	224756|Methanomicrobia	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
SRR25158203_k127_1179017_3	1094980.Mpsy_1082	1.221e-59	211.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,2N9PZ@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
SRR25158203_k127_1179017_4	192952.MM_0142	5.008e-55	198.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,2N9UY@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
SRR25158203_k127_1179017_1	192952.MM_0825	1.091e-105	349.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,2N994@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_1179017_6	304371.MCP_2873	7.204e-51	184.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia	224756|Methanomicrobia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SRR25158203_k127_1179017_0	269797.Mbar_A0486	1.964e-113	375.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,2N9II@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	A_deaminase,Amidohydro_1
SRR25158203_k127_1179017_5	1382304.JNIL01000001_gene3204	1.071e-54	197.0	COG2041@1|root,COG2041@2|Bacteria,1V1P9@1239|Firmicutes,4HFQC@91061|Bacilli,278B0@186823|Alicyclobacillaceae	91061|Bacilli	S	Oxidoreductase molybdopterin binding domain	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
SRR25158203_k127_1201116_7	449447.MAE_01800	2.547e-50	191.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria	1117|Cyanobacteria	O	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2
SRR25158203_k127_1201116_4	1220534.B655_2185	5.529e-67	246.0	COG1520@1|root,arCOG02492@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23PZ1@183925|Methanobacteria	183925|Methanobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
SRR25158203_k127_1201116_15	268739.Nmlp_1041	1.139e-15	89.0	COG0392@1|root,arCOG00899@2157|Archaea,2XTI1@28890|Euryarchaeota,23S13@183963|Halobacteria	183963|Halobacteria	S	integral membrane protein	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SRR25158203_k127_1201116_16	1173020.Cha6605_4097	5.559e-12	76.0	COG1413@1|root,COG1413@2|Bacteria,1G6P1@1117|Cyanobacteria	1117|Cyanobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_PBS
SRR25158203_k127_1201116_12	1304880.JAGB01000002_gene1578	1.047e-28	125.0	COG0457@1|root,COG3012@1|root,COG0457@2|Bacteria,COG3012@2|Bacteria,1V6ZS@1239|Firmicutes,24F35@186801|Clostridia	186801|Clostridia	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	DUF1186,SEC-C
SRR25158203_k127_1201116_0	351160.LRC70	0.0	1127.0	COG0553@1|root,arCOG00883@2157|Archaea,2Y8EC@28890|Euryarchaeota	28890|Euryarchaeota	K	COG0553 Superfamily II DNA RNA helicases, SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
SRR25158203_k127_1201116_3	351160.LRC72	1.728e-101	339.0	COG4279@1|root,arCOG03431@2157|Archaea,2Y44T@28890|Euryarchaeota	28890|Euryarchaeota	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
SRR25158203_k127_1201116_13	485913.Krac_9219	1.026e-20	101.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	485913.Krac_9219|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1201116_18	926551.KB900710_gene1727	6.715e-07	61.0	COG3012@1|root,COG3012@2|Bacteria,4PB0Y@976|Bacteroidetes,1IDM3@117743|Flavobacteriia,1ETA0@1016|Capnocytophaga	976|Bacteroidetes	S	SEC-C Motif Domain Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1201116_2	192952.MM_3352	9.36e-112	372.0	arCOG06752@1|root,arCOG06752@2157|Archaea,2XVSP@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1201116_5	192952.MM_0027	3.341e-61	211.0	arCOG05205@1|root,arCOG05205@2157|Archaea	192952.MM_0027|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1201116_9	879212.DespoDRAFT_02100	1.656e-40	153.0	2AI89@1|root,318NU@2|Bacteria,1P2XK@1224|Proteobacteria,4316Z@68525|delta/epsilon subdivisions,2WWFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1201116_14	879212.DespoDRAFT_02100	5.066e-19	91.0	2AI89@1|root,318NU@2|Bacteria,1P2XK@1224|Proteobacteria,4316Z@68525|delta/epsilon subdivisions,2WWFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1201116_1	304371.MCP_2279	1.483e-211	685.0	COG0514@1|root,COG1204@1|root,arCOG00553@2157|Archaea,arCOG00560@2157|Archaea,2XTDD@28890|Euryarchaeota,2NBIF@224756|Methanomicrobia	224756|Methanomicrobia	L	Pfam:DUF91	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,HRDC,Helicase_C,NucS,Sec63
SRR25158203_k127_1201116_11	1183438.GKIL_0525	3.219e-35	141.0	COG1451@1|root,COG1451@2|Bacteria,1G1B3@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
SRR25158203_k127_1201116_10	251229.Chro_2890	3.408e-40	152.0	2DGVE@1|root,32U82@2|Bacteria,1G87Z@1117|Cyanobacteria,3VMSH@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1201116_8	192952.MM_0019	3.484e-47	186.0	COG1373@1|root,arCOG03167@2157|Archaea,2XXQC@28890|Euryarchaeota,2NAAM@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SRR25158203_k127_1201116_17	224325.AF_2222	8.228e-09	59.0	COG5558@1|root,arCOG07762@2157|Archaea,2Y3B2@28890|Euryarchaeota,246QK@183980|Archaeoglobi	183980|Archaeoglobi	L	to percent identity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1201116_19	224325.AF_0305	2.014e-06	51.0	COG3466@1|root,arCOG03883@2157|Archaea	2157|Archaea	S	to GB L77117 SP Q57808 PID 1499149 percent identity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2080
SRR25158203_k127_1201116_6	1094980.Mpsy_2919	1.438e-55	197.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,2N9R9@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
SRR25158203_k127_1205719_0	192952.MM_0428	5.181e-108	359.0	COG1236@1|root,arCOG00545@2157|Archaea,2XW9F@28890|Euryarchaeota,2N9EJ@224756|Methanomicrobia	224756|Methanomicrobia	J	Metallo-beta-lactamase superfamily	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
SRR25158203_k127_1205719_1	269797.Mbar_A2310	7.452e-15	75.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZ0C@28890|Euryarchaeota,2NB68@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
SRR25158203_k127_1210878_0	192952.MM_1980	5.85e-175	559.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,2NACR@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	fwdB-1	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
SRR25158203_k127_1210878_2	1379698.RBG1_1C00001G1086	6.248e-75	261.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	nueM	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
SRR25158203_k127_1210878_1	266117.Rxyl_0483	5.478e-98	331.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4CQPK@84995|Rubrobacteria	84995|Rubrobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
SRR25158203_k127_1229311_1	1094980.Mpsy_1987	3.242e-193	618.0	COG0323@1|root,arCOG01166@2157|Archaea,2XTK1@28890|Euryarchaeota,2N9DA@224756|Methanomicrobia	224756|Methanomicrobia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
SRR25158203_k127_1229311_5	572480.Arnit_2600	1.152e-17	93.0	28KDN@1|root,2ZA04@2|Bacteria,1RICV@1224|Proteobacteria,431T1@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1229311_3	639282.DEFDS_0320	1.405e-71	251.0	COG0382@1|root,COG0382@2|Bacteria,2GENP@200930|Deferribacteres	200930|Deferribacteres	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SRR25158203_k127_1229311_2	439481.Aboo_1171	1.666e-78	271.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,3F2J6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
SRR25158203_k127_1229311_0	693661.Arcve_1836	6.208e-207	653.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,245VV@183980|Archaeoglobi	183980|Archaeoglobi	H	UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
SRR25158203_k127_1229311_4	224719.Abm4_0443	1.198e-25	109.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,23NKR@183925|Methanobacteria	183925|Methanobacteria	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integrase
SRR25158203_k127_1229831_1	439481.Aboo_1401	1.118e-84	291.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUDB@28890|Euryarchaeota,3F2ZN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
SRR25158203_k127_1229831_0	269797.Mbar_A2752	2.857e-225	709.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
SRR25158203_k127_1229831_2	267377.MMP0522	3.758e-07	62.0	COG1361@1|root,arCOG02079@2157|Archaea,2XTX8@28890|Euryarchaeota,23QFC@183939|Methanococci	183939|Methanococci	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1229831_3	1160721.RBI_II00070	4.649e-05	48.0	COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,3WGDU@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SRR25158203_k127_1238223_3	1459636.NTE_00002	1.269e-15	82.0	arCOG09518@1|root,arCOG09518@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1238223_2	69014.TK0943	2.173e-63	224.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,242R3@183968|Thermococci	183968|Thermococci	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
SRR25158203_k127_1238223_0	351160.RCIX1774	3.315e-140	462.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,2NAP4@224756|Methanomicrobia	224756|Methanomicrobia	C	CoA binding domain	acdA	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
SRR25158203_k127_1238223_1	1232410.KI421418_gene2313	1.782e-124	409.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SRR25158203_k127_1248024_4	1094980.Mpsy_1732	7.316e-82	280.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,2N97A@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
SRR25158203_k127_1248024_2	192952.MM_1318	3.027e-119	393.0	COG0517@1|root,arCOG00607@2157|Archaea,2XTE5@28890|Euryarchaeota,2N998@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
SRR25158203_k127_1248024_0	351160.RCIX438	4.188e-300	930.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
SRR25158203_k127_1248024_1	1094980.Mpsy_0810	6.114e-177	564.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SRR25158203_k127_1248024_7	604354.TSIB_2030	2.647e-27	117.0	COG1708@1|root,arCOG01204@2157|Archaea,2Y1Z8@28890|Euryarchaeota,2446J@183968|Thermococci	183968|Thermococci	L	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_1248024_6	1151117.AJLF01000001_gene995	1.944e-39	151.0	COG2250@1|root,arCOG01191@2157|Archaea,2Y4B9@28890|Euryarchaeota,24459@183968|Thermococci	183968|Thermococci	S	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
SRR25158203_k127_1248024_5	880073.Calab_0133	3.674e-45	179.0	COG0860@1|root,COG1361@1|root,COG3858@1|root,COG0860@2|Bacteria,COG1361@2|Bacteria,COG3858@2|Bacteria,2NQII@2323|unclassified Bacteria	2|Bacteria	M	Glyco_18	-	-	3.4.17.14,3.5.1.28	ko:K01448,ko:K07260,ko:K20276	ko00550,ko01100,ko01502,ko01503,ko02020,ko02024,map00550,map01100,map01502,map01503,map02020,map02024	M00651,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko03036	-	-	-	Amidase_3,CHAP,CW_binding_2,Cu_amine_oxidN1,GBS_Bsp-like,Glyco_hydro_18,Glyco_hydro_25,Peptidase_C39_2,SH3_5,VanY,YSIRK_signal
SRR25158203_k127_1248024_8	203124.Tery_0117	1.524e-19	104.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1G04D@1117|Cyanobacteria,1H779@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,Peptidase_S8,SdrD_B
SRR25158203_k127_1248024_3	1499967.BAYZ01000080_gene935	3.165e-85	308.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
SRR25158203_k127_1264214_4	436308.Nmar_1604	1.111e-14	79.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SRR25158203_k127_1264214_3	304371.MCP_1348	1.073e-62	225.0	COG0483@1|root,arCOG01349@2157|Archaea,2XUBB@28890|Euryarchaeota,2N9NZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SRR25158203_k127_1264214_2	351160.RRC41	3.76e-63	222.0	COG0529@1|root,arCOG01040@2157|Archaea,2XU4H@28890|Euryarchaeota,2NBDX@224756|Methanomicrobia	224756|Methanomicrobia	P	Adenylylsulphate kinase	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
SRR25158203_k127_1264214_1	351160.RRC43	7.85e-142	458.0	arCOG01186@1|root,arCOG01186@2157|Archaea	2157|Archaea	G	Mn2 dependent serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
SRR25158203_k127_1264214_0	304371.MCP_1344	3.227e-214	670.0	COG0499@1|root,arCOG04137@2157|Archaea,2XT4S@28890|Euryarchaeota,2N9AH@224756|Methanomicrobia	224756|Methanomicrobia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SRR25158203_k127_132433_4	589924.Ferp_0909	2.617e-06	53.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2Y8J1@28890|Euryarchaeota,247IF@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
SRR25158203_k127_132433_0	693661.Arcve_1012	0.0	1436.0	COG1372@1|root,COG1933@1|root,arCOG03146@1|root,arCOG03145@2157|Archaea,arCOG03146@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
SRR25158203_k127_132433_1	192952.MM_0484	1.34e-64	226.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,2N9RQ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
SRR25158203_k127_132433_2	192952.MM_2791	1.884e-42	160.0	COG2003@1|root,arCOG04919@2157|Archaea,2XY1U@28890|Euryarchaeota,2N9SM@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
SRR25158203_k127_132433_3	1094980.Mpsy_2743	4.489e-31	123.0	COG2003@1|root,arCOG04919@2157|Archaea,2XY1U@28890|Euryarchaeota,2N9SM@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
SRR25158203_k127_1347878_1	1321778.HMPREF1982_00055	2.976e-103	343.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,26A0H@186813|unclassified Clostridiales	186801|Clostridia	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SRR25158203_k127_1347878_2	304371.MCP_1453	2.267e-60	211.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,2N9NP@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
SRR25158203_k127_1347878_3	304371.MCP_0147	6.304e-31	129.0	COG0170@1|root,arCOG01880@2157|Archaea	2157|Archaea	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1347878_0	269797.Mbar_A1209	4.572e-256	802.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
SRR25158203_k127_1347878_4	589924.Ferp_0426	5.762e-29	128.0	COG0582@1|root,arCOG01242@2157|Archaea,2Y83U@28890|Euryarchaeota,246MT@183980|Archaeoglobi	28890|Euryarchaeota	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
SRR25158203_k127_1354909_2	596152.DesU5LDRAFT_0535	1.889e-234	743.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2M85I@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SRR25158203_k127_1354909_12	693661.Arcve_1801	2.361e-46	179.0	COG0392@1|root,arCOG00899@2157|Archaea,2XYAI@28890|Euryarchaeota,246AB@183980|Archaeoglobi	183980|Archaeoglobi	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
SRR25158203_k127_1354909_0	1094980.Mpsy_1307	0.0	1052.0	COG2217@1|root,arCOG02763@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iAF692.Mbar_A1889	E1-E2_ATPase,HMA,Hydrolase
SRR25158203_k127_1354909_18	1094980.Mpsy_1308	8.051e-15	76.0	arCOG05178@1|root,arCOG05178@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1354909_19	1094980.Mpsy_0286	5.376e-12	66.0	COG2026@1|root,arCOG02414@2157|Archaea,2Y78J@28890|Euryarchaeota,2NBEU@224756|Methanomicrobia	224756|Methanomicrobia	K	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
SRR25158203_k127_1354909_4	86416.Clopa_0749	8.028e-172	546.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,36EK3@31979|Clostridiaceae	186801|Clostridia	K	aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
SRR25158203_k127_1354909_1	192952.MM_1287	6.93e-251	787.0	COG1032@1|root,arCOG04984@2157|Archaea,2XUS3@28890|Euryarchaeota,2N97H@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
SRR25158203_k127_1354909_3	192952.MM_1538	1.272e-227	713.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,2N90W@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
SRR25158203_k127_1354909_17	797209.ZOD2009_07834	1.935e-20	93.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,23W4Z@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1354909_15	192952.MM_2352	7.342e-27	112.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y49G@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1354909_16	351160.RCIX1527	9.349e-27	110.0	COG1476@1|root,arCOG01864@2157|Archaea,2Y089@28890|Euryarchaeota,2NA1I@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SRR25158203_k127_1354909_14	1041930.Mtc_0053	2.112e-29	125.0	COG2881@1|root,arCOG02054@2157|Archaea	2157|Archaea	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
SRR25158203_k127_1354909_8	269797.Mbar_A0681	1.789e-82	281.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2N9GV@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR25158203_k127_1354909_7	192952.MM_1057	7.947e-92	310.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUT0@28890|Euryarchaeota,2NAN6@224756|Methanomicrobia	224756|Methanomicrobia	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR25158203_k127_1354909_9	192952.MM_1056	4.963e-77	272.0	COG1668@1|root,arCOG01462@2157|Archaea,2XX4X@28890|Euryarchaeota,2NAR7@224756|Methanomicrobia	224756|Methanomicrobia	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SRR25158203_k127_1354909_10	1094980.Mpsy_1258	6.771e-64	234.0	arCOG02083@1|root,arCOG02083@2157|Archaea,2Y2FI@28890|Euryarchaeota,2NA9F@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1354909_6	1041930.Mtc_0564	1.456e-95	328.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,2NAM2@224756|Methanomicrobia	224756|Methanomicrobia	P	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SRR25158203_k127_1354909_11	1173024.KI912149_gene6381	7.433e-59	207.0	COG4891@1|root,COG4891@2|Bacteria,1G7CI@1117|Cyanobacteria	1117|Cyanobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
SRR25158203_k127_1354909_13	720554.Clocl_3281	1.383e-39	163.0	COG5650@1|root,COG5650@2|Bacteria,1TQVD@1239|Firmicutes,25CFN@186801|Clostridia,3WM5M@541000|Ruminococcaceae	186801|Clostridia	S	integral membrane protein	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT_2
SRR25158203_k127_1354909_5	1041930.Mtc_1125	3.162e-127	420.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
SRR25158203_k127_1356411_13	224325.AF_2222	2.365e-09	59.0	COG5558@1|root,arCOG07762@2157|Archaea,2Y3B2@28890|Euryarchaeota,246QK@183980|Archaeoglobi	183980|Archaeoglobi	L	to percent identity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1356411_8	246194.CHY_1799	2.606e-42	164.0	2DBZQ@1|root,2ZC2Y@2|Bacteria,1V2KN@1239|Firmicutes,24G8V@186801|Clostridia,42I8U@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1356411_14	573064.Mefer_1505	4.104e-09	62.0	COG0662@1|root,arCOG03003@2157|Archaea	2157|Archaea	G	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SRR25158203_k127_1356411_3	706587.Desti_4722	2.589e-108	371.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
SRR25158203_k127_1356411_10	706587.Desti_4721	5.071e-29	119.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1356411_4	999630.TUZN_1272	1.925e-94	319.0	COG0003@1|root,arCOG02849@2157|Archaea,2XQWS@28889|Crenarchaeota	28889|Crenarchaeota	D	PFAM Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SRR25158203_k127_1356411_6	292459.STH680	2.915e-89	304.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,24SV7@186801|Clostridia	186801|Clostridia	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SRR25158203_k127_1356411_9	713586.KB900536_gene328	8.599e-30	128.0	COG2133@1|root,COG2133@2|Bacteria,1QWB2@1224|Proteobacteria	1224|Proteobacteria	G	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
SRR25158203_k127_1356411_15	439235.Dalk_0950	6.39e-08	57.0	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MM5C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
SRR25158203_k127_1356411_12	1094980.Mpsy_2968	4.773e-14	76.0	arCOG02104@1|root,arCOG02104@2157|Archaea,2XZI1@28890|Euryarchaeota,2NB8X@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1356411_2	192952.MM_1874	7.966e-115	377.0	COG0391@1|root,arCOG04395@2157|Archaea,2XTPP@28890|Euryarchaeota,2N94E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
SRR25158203_k127_1356411_5	1094980.Mpsy_2101	3.265e-90	304.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota,2N9R3@224756|Methanomicrobia	28890|Euryarchaeota	V	TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRR25158203_k127_1356411_1	1094980.Mpsy_2449	7.963e-126	410.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBN9@224756|Methanomicrobia	28890|Euryarchaeota	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR25158203_k127_1356411_7	192952.MM_1820	3.376e-53	193.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,2N9X8@224756|Methanomicrobia	224756|Methanomicrobia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
SRR25158203_k127_1356411_11	408672.NBCG_00084	6.559e-16	81.0	2DRD4@1|root,33B9X@2|Bacteria,2GTDE@201174|Actinobacteria,4DW52@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1356411_0	246969.TAM4_199	4.879e-127	420.0	COG1106@1|root,arCOG03237@2157|Archaea,2Y6N3@28890|Euryarchaeota,244XI@183968|Thermococci	183968|Thermococci	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
SRR25158203_k127_1358778_17	269797.Mbar_A0260	1.223e-19	90.0	COG4892@1|root,arCOG02922@2157|Archaea,2Y64K@28890|Euryarchaeota,2NBAN@224756|Methanomicrobia	2157|Archaea	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
SRR25158203_k127_1358778_2	192952.MM_1700	2.291e-217	699.0	COG0826@1|root,arCOG03203@2157|Archaea,2XT7F@28890|Euryarchaeota,2N97J@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
SRR25158203_k127_1358778_9	153721.MYP_864	8.814e-99	328.0	COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes,47M76@768503|Cytophagia	976|Bacteroidetes	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
SRR25158203_k127_1358778_11	1094980.Mpsy_0102	1.133e-63	223.0	COG0218@1|root,arCOG00355@2157|Archaea,2XTV8@28890|Euryarchaeota,2N9M7@224756|Methanomicrobia	224756|Methanomicrobia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
SRR25158203_k127_1358778_8	1094980.Mpsy_0103	1.432e-99	334.0	COG0608@1|root,arCOG00424@2157|Archaea,2XVF6@28890|Euryarchaeota,2N93U@224756|Methanomicrobia	224756|Methanomicrobia	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
SRR25158203_k127_1358778_20	886882.PPSC2_c4893	0.0003673	53.0	COG1361@1|root,COG1361@2|Bacteria,1V4V3@1239|Firmicutes,4HT0D@91061|Bacilli,26QKX@186822|Paenibacillaceae	91061|Bacilli	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SRR25158203_k127_1358778_0	192952.MM_0426	1.143e-277	863.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,2N9CQ@224756|Methanomicrobia	224756|Methanomicrobia	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
SRR25158203_k127_1358778_19	192952.MM_0427	1.794e-16	83.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y17T@28890|Euryarchaeota,2NA3Y@224756|Methanomicrobia	224756|Methanomicrobia	S	RNase L inhibitor, RLI	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1358778_3	1094980.Mpsy_1385	2.1e-134	434.0	COG0548@1|root,arCOG00862@2157|Archaea,2XTW9@28890|Euryarchaeota,2N912@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
SRR25158203_k127_1358778_18	304371.MCP_0002	1.962e-17	88.0	COG3729@1|root,arCOG11115@2157|Archaea	2157|Archaea	S	general stress protein B in uncultured methanogenic archaeon (Q0W564)	-	-	-	-	-	-	-	-	-	-	-	-	KGG
SRR25158203_k127_1358778_10	545243.BAEV01000113_gene2402	1.736e-79	272.0	COG0500@1|root,COG2226@2|Bacteria,1V3HT@1239|Firmicutes,24EY6@186801|Clostridia,36H88@31979|Clostridiaceae	186801|Clostridia	Q	SAM-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1358778_1	269797.Mbar_A2069	5.437e-262	816.0	COG0129@1|root,arCOG04045@2157|Archaea,2XSW2@28890|Euryarchaeota,2N992@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2069	ILVD_EDD
SRR25158203_k127_1358778_14	574087.Acear_1502	1.718e-24	112.0	2ACGP@1|root,3122D@2|Bacteria,1V5NE@1239|Firmicutes,24J4I@186801|Clostridia,3WBNQ@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1358778_6	215803.DB30_2216	3.385e-124	444.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
SRR25158203_k127_1358778_7	251221.35211855	1.247e-122	408.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
SRR25158203_k127_1358778_15	35841.BT1A1_1710	8.56e-22	105.0	COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,4HBDU@91061|Bacilli,1ZBUJ@1386|Bacillus	91061|Bacilli	M	Mechanosensitive ion channel	yhdY	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
SRR25158203_k127_1358778_5	1094980.Mpsy_1563	3.802e-129	420.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,2N9EE@224756|Methanomicrobia	224756|Methanomicrobia	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
SRR25158203_k127_1358778_16	269797.Mbar_A1194	1.348e-20	94.0	arCOG04996@1|root,arCOG04996@2157|Archaea,2Y4KJ@28890|Euryarchaeota,2NB33@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1358778_12	456442.Mboo_2447	3.889e-59	210.0	COG1704@1|root,arCOG04574@2157|Archaea,2XX6E@28890|Euryarchaeota,2N9YK@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
SRR25158203_k127_1358778_4	693661.Arcve_1781	1.061e-129	436.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
SRR25158203_k127_1366572_0	192952.MM_1321	2.551e-141	453.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,2N97E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
SRR25158203_k127_1366572_3	1094980.Mpsy_1797	6.302e-30	121.0	COG1745@1|root,arCOG02254@2157|Archaea,2XZ09@28890|Euryarchaeota,2NA4W@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0058	-	-	-	-	-	-	-	-	-	-	-	-	UPF0058
SRR25158203_k127_1366572_1	565033.GACE_0310	4.058e-92	317.0	arCOG00516@1|root,arCOG04739@1|root,arCOG00516@2157|Archaea,arCOG04739@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
SRR25158203_k127_1366572_4	589924.Ferp_0183	5.382e-29	124.0	arCOG00516@1|root,arCOG00516@2157|Archaea,2Y3UM@28890|Euryarchaeota,2475H@183980|Archaeoglobi	183980|Archaeoglobi	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SRR25158203_k127_1366572_2	880073.Calab_1228	8.484e-63	222.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
SRR25158203_k127_1366572_5	1183377.Py04_0095	8.306e-15	76.0	COG0640@1|root,arCOG01679@2157|Archaea,2XZT0@28890|Euryarchaeota,244AB@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SRR25158203_k127_1393114_6	192952.MM_0686	1.77e-18	89.0	COG1614@1|root,arCOG04360@2157|Archaea,2XU0D@28890|Euryarchaeota,2N95I@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex)	cdhC	-	-	ko:K00193	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00357,M00422	R09096,R10219	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
SRR25158203_k127_1393114_4	1094980.Mpsy_2892	1.266e-99	331.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota,2N9QI@224756|Methanomicrobia	224756|Methanomicrobia	D	AAA domain	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	AAA_31,CbiA
SRR25158203_k127_1393114_3	269797.Mbar_A0021	6.012e-131	424.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,2N940@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
SRR25158203_k127_1393114_0	1220534.B655_0758	4.243e-189	599.0	COG0677@1|root,arCOG00252@2157|Archaea,2XUCC@28890|Euryarchaeota,23PXN@183925|Methanobacteria	183925|Methanobacteria	M	UDP binding domain	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SRR25158203_k127_1393114_1	1304874.JAFY01000007_gene1854	8.563e-157	500.0	COG1089@1|root,COG1089@2|Bacteria,3TAKQ@508458|Synergistetes	508458|Synergistetes	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
SRR25158203_k127_1393114_2	56780.SYN_00585	5.214e-146	468.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,42M12@68525|delta/epsilon subdivisions,2WIJX@28221|Deltaproteobacteria,2MQ3S@213462|Syntrophobacterales	28221|Deltaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1312	Epimerase
SRR25158203_k127_1393114_5	1121440.AUMA01000002_gene2147	6.812e-59	211.0	COG4627@1|root,COG4627@2|Bacteria,1N2HA@1224|Proteobacteria	1224|Proteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR25158203_k127_1393114_7	946483.Cenrod_2074	0.0002708	49.0	COG4122@1|root,COG4641@1|root,COG4122@2|Bacteria,COG4641@2|Bacteria	2|Bacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Glyco_trans_1_2,Glycos_transf_2,Methyltransf_2,Methyltransf_24,TPR_1,TPR_8,TylF
SRR25158203_k127_1409831_5	647113.Metok_0590	2.177e-12	70.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,23Q0W@183939|Methanococci	183939|Methanococci	F	Glycinamide ribonucleotide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
SRR25158203_k127_1409831_4	1191460.F959_03047	4.523e-18	91.0	COG0454@1|root,COG0456@2|Bacteria,1RHB7@1224|Proteobacteria,1S3TD@1236|Gammaproteobacteria,3NN1P@468|Moraxellaceae	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	ectA	-	2.3.1.178	ko:K06718	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06978	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
SRR25158203_k127_1409831_6	1382305.AZUC01000046_gene624	9.176e-05	48.0	COG0530@1|root,COG0530@2|Bacteria,1TRX0@1239|Firmicutes,4HCXU@91061|Bacilli,26GSB@186818|Planococcaceae	91061|Bacilli	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
SRR25158203_k127_1409831_1	269797.Mbar_A0905	6.554e-173	548.0	COG4756@1|root,arCOG04052@2157|Archaea,2XWD2@28890|Euryarchaeota,2NABI@224756|Methanomicrobia	224756|Methanomicrobia	P	Protein of unknown function (DUF1646)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1646
SRR25158203_k127_1409831_2	593750.Metfor_0716	2.021e-70	248.0	COG0589@1|root,arCOG00449@2157|Archaea,2XV1Y@28890|Euryarchaeota	28890|Euryarchaeota	T	COG0589 Universal stress protein UspA and related nucleotide-binding	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Usp
SRR25158203_k127_1409831_3	1047013.AQSP01000119_gene1318	2.572e-68	237.0	COG4843@1|root,COG4843@2|Bacteria,2NPKB@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
SRR25158203_k127_1409831_0	351160.RRC148	9.189e-217	687.0	COG1509@1|root,arCOG03246@2157|Archaea,2XW0K@28890|Euryarchaeota,2NBJ6@224756|Methanomicrobia	224756|Methanomicrobia	E	4Fe-4S single cluster domain	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_14
SRR25158203_k127_1424458_1	1408473.JHXO01000011_gene3149	7.369e-56	201.0	COG1611@1|root,COG1611@2|Bacteria,4NGWU@976|Bacteroidetes,2FNYZ@200643|Bacteroidia	976|Bacteroidetes	S	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
SRR25158203_k127_1424458_2	573063.Metin_0946	6.832e-50	189.0	COG0003@1|root,arCOG02849@2157|Archaea,2XT6V@28890|Euryarchaeota,23QFQ@183939|Methanococci	183939|Methanococci	D	TIGRFAM arsenite-activated ATPase ArsA	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SRR25158203_k127_1424458_6	1151117.AJLF01000001_gene1735	1.053e-13	79.0	COG3413@1|root,arCOG02271@2157|Archaea,2Y21Q@28890|Euryarchaeota,2443T@183968|Thermococci	183968|Thermococci	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
SRR25158203_k127_1424458_11	269797.Mbar_A0817	3.68e-05	49.0	arCOG03492@1|root,arCOG03492@2157|Archaea,2Y5WG@28890|Euryarchaeota,2NBFI@224756|Methanomicrobia	224756|Methanomicrobia	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
SRR25158203_k127_1424458_4	351160.RCIX1274	6.924e-41	163.0	COG0640@1|root,arCOG01686@2157|Archaea,2XX9R@28890|Euryarchaeota,2N9WK@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SRR25158203_k127_1424458_7	402880.MmarC5_0967	1.184e-13	78.0	COG0640@1|root,arCOG01686@2157|Archaea,2XYZ4@28890|Euryarchaeota,23R6H@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SRR25158203_k127_1424458_10	880073.Calab_3333	3.392e-05	57.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1424458_8	635013.TherJR_1425	3.644e-11	75.0	COG3005@1|root,COG4733@1|root,COG3005@2|Bacteria,COG4733@2|Bacteria,1UT1Y@1239|Firmicutes,250WR@186801|Clostridia,265BU@186807|Peptococcaceae	186801|Clostridia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
SRR25158203_k127_1424458_9	1121918.ARWE01000001_gene1797	6.594e-11	78.0	COG1404@1|root,COG1404@2|Bacteria,1QYWU@1224|Proteobacteria,42VXP@68525|delta/epsilon subdivisions,2X7PK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1424458_5	1042877.GQS_00285	3.019e-14	89.0	arCOG02499@1|root,arCOG02526@1|root,arCOG02540@1|root,arCOG02499@2157|Archaea,arCOG02526@2157|Archaea,arCOG02540@2157|Archaea,2Y66W@28890|Euryarchaeota,242VN@183968|Thermococci	183968|Thermococci	P	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
SRR25158203_k127_1424458_0	243231.GSU2075	9.961e-95	329.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42SPI@68525|delta/epsilon subdivisions,2WQM8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	B_lectin,Inhibitor_I9,Peptidase_S8,Somatomedin_B
SRR25158203_k127_1440271_5	1094980.Mpsy_0983	1.017e-38	159.0	COG1404@1|root,arCOG02538@1|root,arCOG03439@1|root,arCOG00702@2157|Archaea,arCOG02538@2157|Archaea,arCOG03439@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
SRR25158203_k127_1440271_3	269797.Mbar_A0244	9.817e-71	242.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2N9JK@224756|Methanomicrobia	224756|Methanomicrobia	E	Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B	hacB	-	4.2.1.114	ko:K16793	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00433,M00608	R03444,R04371,R09720,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2270	Aconitase_C
SRR25158203_k127_1440271_1	192952.MM_0644	1.07e-97	329.0	arCOG04973@1|root,arCOG04973@2157|Archaea,2XX73@28890|Euryarchaeota,2N9K2@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1440271_7	589924.Ferp_0909	9.522e-06	52.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2Y8J1@28890|Euryarchaeota,247IF@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
SRR25158203_k127_1440271_6	195522.BD01_2072	9.225e-19	92.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y0GG@28890|Euryarchaeota,2448Z@183968|Thermococci	183968|Thermococci	V	Domain of unknown function (DUF3368)	-	-	-	ko:K07066	-	-	-	-	ko00000	-	-	-	DUF3368
SRR25158203_k127_1440271_0	1094980.Mpsy_2352	5.628e-140	451.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N94T@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	aksF	-	1.1.1.87	ko:K10978	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R01934,R01936,R04862,R08214,R08215	RC00084,RC00114,RC00626	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SRR25158203_k127_1440271_4	485915.Dret_1648	8.203e-48	197.0	COG2202@1|root,COG2204@1|root,COG3290@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
SRR25158203_k127_1440271_2	404589.Anae109_3161	2.76e-96	347.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase A domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,sCache_3_2
SRR25158203_k127_1440271_8	1183377.Py04_1137	1.17e-05	50.0	COG0306@1|root,arCOG02267@2157|Archaea,2XSUU@28890|Euryarchaeota,242VF@183968|Thermococci	183968|Thermococci	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
SRR25158203_k127_145439_0	1457250.BBMO01000002_gene2722	5.699e-28	118.0	COG0730@1|root,arCOG02050@2157|Archaea,2XT5Y@28890|Euryarchaeota,23U92@183963|Halobacteria	183963|Halobacteria	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
SRR25158203_k127_145439_1	192952.MM_2391	3.124e-27	112.0	arCOG03896@1|root,arCOG03896@2157|Archaea	2157|Archaea	E	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769,Glu_synthase
SRR25158203_k127_145439_3	85963.jhp_0723	0.0001475	44.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2YMV9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
SRR25158203_k127_145439_2	351160.RCIX1586	2.531e-18	90.0	COG0655@1|root,arCOG00510@2157|Archaea	2157|Archaea	C	NAD(P)H dehydrogenase (quinone) activity	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
SRR25158203_k127_1464994_0	1094980.Mpsy_2247	7.392e-171	548.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR25158203_k127_1473225_2	269797.Mbar_A2503	3.672e-107	352.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
SRR25158203_k127_1473225_15	269797.Mbar_A1149	1.774e-14	74.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,2NA41@224756|Methanomicrobia	224756|Methanomicrobia	J	structural constituent of ribosome	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
SRR25158203_k127_1473225_1	192952.MM_1201	9.358e-124	402.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SRR25158203_k127_1473225_3	269797.Mbar_A1151	5.237e-107	352.0	COG0289@1|root,arCOG04393@2157|Archaea,2XTJU@28890|Euryarchaeota,2N9BV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
SRR25158203_k127_1473225_5	304371.MCP_0292	1.359e-86	296.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,2N93Q@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1473225_8	679926.Mpet_1989	1.883e-52	194.0	COG2236@1|root,arCOG00040@2157|Archaea,2XYCC@28890|Euryarchaeota,2NBH5@224756|Methanomicrobia	224756|Methanomicrobia	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	iAF692.Mbar_A3178	Pribosyltran
SRR25158203_k127_1473225_13	795359.TOPB45_0303	2.362e-30	123.0	COG1254@1|root,COG1254@2|Bacteria,2GHZK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
SRR25158203_k127_1473225_11	1094980.Mpsy_1581	2.227e-33	136.0	COG1326@1|root,arCOG02680@2157|Archaea,2XUFW@28890|Euryarchaeota,2NA07@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal Zn-finger protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1473225_7	1041930.Mtc_2001	3.363e-69	242.0	COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,2N9U4@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
SRR25158203_k127_1473225_10	192952.MM_2717	9.796e-45	183.0	arCOG03269@1|root,arCOG03269@2157|Archaea,2Y2NU@28890|Euryarchaeota,2NAPV@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SRR25158203_k127_1473225_16	1094980.Mpsy_2197	1.222e-13	72.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y6WB@28890|Euryarchaeota,2NA5T@224756|Methanomicrobia	224756|Methanomicrobia	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
SRR25158203_k127_1473225_0	269797.Mbar_A3513	6.616e-175	557.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
SRR25158203_k127_1473225_14	1459636.NTE_03342	5.068e-18	93.0	arCOG10350@1|root,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1473225_12	304371.MCP_2728	9.901e-33	134.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y1MD@28890|Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1473225_18	318424.EU78_26465	5.219e-07	63.0	COG2203@1|root,COG2508@1|root,COG2203@2|Bacteria,COG2508@2|Bacteria,2GM1G@201174|Actinobacteria,2353M@1762|Mycobacteriaceae	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HTH_30
SRR25158203_k127_1473225_9	387631.Asulf_01671	5.657e-48	195.0	arCOG02367@1|root,arCOG06940@1|root,arCOG02367@2157|Archaea,arCOG06940@2157|Archaea,2Y7WC@28890|Euryarchaeota	28890|Euryarchaeota	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
SRR25158203_k127_1473225_17	768679.TTX_0875	1.181e-09	72.0	COG0640@1|root,arCOG00731@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SRR25158203_k127_1473225_4	192952.MM_1500	5.455e-106	356.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
SRR25158203_k127_1473225_6	304371.MCP_2363	1.693e-74	258.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SRR25158203_k127_1527189_3	192952.MM_2210	9.17e-91	319.0	COG1287@1|root,arCOG02043@2157|Archaea,2XX8Q@28890|Euryarchaeota,2NADZ@224756|Methanomicrobia	224756|Methanomicrobia	M	Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
SRR25158203_k127_1527189_2	351160.RCIX1438	1.093e-148	480.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N9G1@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transferase
SRR25158203_k127_1527189_1	1094980.Mpsy_2688	1.19e-155	501.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N92Y@224756|Methanomicrobia	224756|Methanomicrobia	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SRR25158203_k127_1527189_0	1304880.JAGB01000003_gene1121	4.052e-207	659.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SRR25158203_k127_1535899_5	304371.MCP_0864	6.934e-06	53.0	COG1708@1|root,arCOG01195@2157|Archaea	2157|Archaea	S	DNA polymerase beta domain protein region	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_1535899_3	269797.Mbar_A0700	3.279e-46	171.0	COG0599@1|root,arCOG02148@2157|Archaea,2XYR2@28890|Euryarchaeota,2NBIG@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_1535899_0	192952.MM_2288	3.245e-104	344.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,2N955@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,TRAM
SRR25158203_k127_1535899_1	192952.MM_1826	2.162e-71	252.0	arCOG03479@1|root,arCOG03479@2157|Archaea,2Y0TG@28890|Euryarchaeota,2NB1D@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1535899_2	1094980.Mpsy_0962	2.757e-61	218.0	COG4749@1|root,arCOG04411@2157|Archaea,2XT50@28890|Euryarchaeota,2N9VH@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2150)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2150
SRR25158203_k127_1535899_4	1094980.Mpsy_2344	2.457e-25	106.0	COG0745@1|root,arCOG02595@2157|Archaea,2XZSB@28890|Euryarchaeota,2NAXV@224756|Methanomicrobia	224756|Methanomicrobia	T	cheY-homologous receiver domain	-	-	-	ko:K07668	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SRR25158203_k127_1547867_15	211165.AJLN01000017_gene2126	9.545e-09	59.0	COG0526@1|root,COG0526@2|Bacteria,1GERV@1117|Cyanobacteria,1JM98@1189|Stigonemataceae	1117|Cyanobacteria	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
SRR25158203_k127_1547867_3	398767.Glov_3724	4.165e-62	220.0	COG0655@1|root,COG0655@2|Bacteria,1QF4Z@1224|Proteobacteria,42QAY@68525|delta/epsilon subdivisions,2WMME@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SRR25158203_k127_1547867_9	641524.ADICYQ_0782	5.306e-27	120.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRR25158203_k127_1547867_5	398767.Glov_3724	6.389e-40	156.0	COG0655@1|root,COG0655@2|Bacteria,1QF4Z@1224|Proteobacteria,42QAY@68525|delta/epsilon subdivisions,2WMME@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SRR25158203_k127_1547867_4	269799.Gmet_2646	7.793e-50	183.0	COG2128@1|root,COG2128@2|Bacteria,1RHU7@1224|Proteobacteria,42SKU@68525|delta/epsilon subdivisions,2WT3P@28221|Deltaproteobacteria,43VXH@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_1547867_6	456442.Mboo_1133	2.632e-33	129.0	COG4746@1|root,arCOG02797@2157|Archaea,2Y6V4@28890|Euryarchaeota,2N9YW@224756|Methanomicrobia	224756|Methanomicrobia	S	MTH865-like family	-	-	-	-	-	-	-	-	-	-	-	-	MTH865
SRR25158203_k127_1547867_13	679926.Mpet_0902	2.643e-11	64.0	COG4746@1|root,arCOG02797@2157|Archaea,2Y6V4@28890|Euryarchaeota,2N9YW@224756|Methanomicrobia	224756|Methanomicrobia	S	MTH865-like family	-	-	-	-	-	-	-	-	-	-	-	-	MTH865
SRR25158203_k127_1547867_2	1041930.Mtc_2216	4.196e-79	271.0	COG0640@1|root,arCOG00734@2157|Archaea,2XXHJ@28890|Euryarchaeota,2N9JR@224756|Methanomicrobia	224756|Methanomicrobia	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SRR25158203_k127_1547867_10	589924.Ferp_0162	9.039e-24	106.0	COG3355@1|root,arCOG02242@2157|Archaea,2XY1Y@28890|Euryarchaeota,246F2@183980|Archaeoglobi	183980|Archaeoglobi	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
SRR25158203_k127_1547867_16	1280688.AUJB01000012_gene2547	2.467e-06	50.0	COG3012@1|root,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia,3NGWD@46205|Pseudobutyrivibrio	186801|Clostridia	S	SEC-C motif	secA_2	-	-	-	-	-	-	-	-	-	-	-	SEC-C
SRR25158203_k127_1547867_14	269797.Mbar_A2887	3.417e-09	59.0	arCOG04838@1|root,arCOG04838@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1547867_1	1041930.Mtc_1635	1.553e-132	429.0	COG0535@1|root,arCOG00956@2157|Archaea,2XU9R@28890|Euryarchaeota,2N96X@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
SRR25158203_k127_1547867_12	269797.Mbar_A2887	8.248e-15	75.0	arCOG04838@1|root,arCOG04838@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1547867_11	1094508.Tsac_1153	2.364e-20	91.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,42H59@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
SRR25158203_k127_1547867_0	1094980.Mpsy_2022	1.429e-163	523.0	COG0426@1|root,arCOG00509@2157|Archaea,2XSUD@28890|Euryarchaeota,2N9E8@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	fprA-1	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
SRR25158203_k127_1547867_8	35841.BT1A1_0851	2.309e-27	128.0	COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,4HDFR@91061|Bacilli	91061|Bacilli	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SRR25158203_k127_1547867_7	402881.Plav_0320	8.552e-33	131.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SRR25158203_k127_1563515_2	545693.BMQ_4931	2.024e-50	188.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,4HAPD@91061|Bacilli,1ZBFE@1386|Bacillus	91061|Bacilli	P	phosphate transporter	cysP	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K16331	-	-	-	-	ko00000,ko02000	2.A.20.4	-	-	PHO4
SRR25158203_k127_1563515_1	304371.MCP_2556	1.79e-81	278.0	COG4021@1|root,arCOG03218@2157|Archaea,2XWU9@28890|Euryarchaeota,2N9I7@224756|Methanomicrobia	224756|Methanomicrobia	J	tRNAHis guanylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thg1,Thg1C
SRR25158203_k127_1563515_3	1094980.Mpsy_2155	7.008e-26	110.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota,2N9Y7@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
SRR25158203_k127_1563515_0	1094980.Mpsy_2659	1.866e-251	786.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,2N9CR@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
SRR25158203_k127_1563515_4	269797.Mbar_A2672	1.181e-25	107.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,2N92N@224756|Methanomicrobia	224756|Methanomicrobia	D	PFAM PP-loop domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
SRR25158203_k127_1587552_5	1229909.NSED_08125	4.744e-60	215.0	COG0506@1|root,arCOG06322@2157|Archaea,41SY1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
SRR25158203_k127_1587552_8	1094980.Mpsy_2326	8.003e-37	142.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,2N9TR@224756|Methanomicrobia	224756|Methanomicrobia	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
SRR25158203_k127_1587552_9	192952.MM_1403	3.531e-31	131.0	COG1183@1|root,arCOG00671@2157|Archaea,2XT0G@28890|Euryarchaeota,2NAYG@224756|Methanomicrobia	224756|Methanomicrobia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0874	CDP-OH_P_transf
SRR25158203_k127_1587552_7	1157635.KB892013_gene2469	1.181e-39	155.0	COG0688@1|root,COG0688@2|Bacteria,2GMMF@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
SRR25158203_k127_1587552_4	192952.MM_1401	4.251e-74	259.0	COG4083@1|root,arCOG04471@2157|Archaea,2XTQZ@28890|Euryarchaeota,2N9VN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
SRR25158203_k127_1587552_0	269797.Mbar_A0004	6.949e-182	582.0	COG0165@1|root,arCOG01748@2157|Archaea,2XUWS@28890|Euryarchaeota,2N9AC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
SRR25158203_k127_1587552_2	1041930.Mtc_1102	1.729e-93	319.0	COG0598@1|root,arCOG02265@2157|Archaea,2Y2PC@28890|Euryarchaeota,2NAPG@224756|Methanomicrobia	224756|Methanomicrobia	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
SRR25158203_k127_1587552_10	1443665.JACA01000072_gene1858	4.853e-23	111.0	COG0823@1|root,COG0823@2|Bacteria,4PI4J@976|Bacteroidetes,1II35@117743|Flavobacteriia,2YKPX@290174|Aquimarina	976|Bacteroidetes	U	Domain of unknown function (DUF5050)	-	-	-	-	-	-	-	-	-	-	-	-	PD40
SRR25158203_k127_1587552_1	1094980.Mpsy_2902	5.915e-141	454.0	COG0057@1|root,arCOG00493@2157|Archaea,2XT16@28890|Euryarchaeota,2N93N@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
SRR25158203_k127_1587552_11	387631.Asulf_01634	4.498e-07	53.0	COG1532@1|root,arCOG04856@2157|Archaea	2157|Archaea	S	PFAM RNA-binding protein	-	-	-	ko:K06964	-	-	-	-	ko00000	-	-	-	RNA_bind_2
SRR25158203_k127_1587552_3	1094980.Mpsy_2322	1.632e-85	292.0	COG4801@1|root,arCOG02471@2157|Archaea,2XSX3@28890|Euryarchaeota,2N9N8@224756|Methanomicrobia	224756|Methanomicrobia	S	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,Hexapep
SRR25158203_k127_1587552_6	192952.MM_2375	7.641e-58	209.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,2N9NE@224756|Methanomicrobia	224756|Methanomicrobia	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
SRR25158203_k127_1630472_5	1131269.AQVV01000007_gene1058	1.623e-13	79.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	pcmG	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
SRR25158203_k127_1630472_0	196162.Noca_1617	1.144e-85	292.0	COG0053@1|root,COG0053@2|Bacteria	2|Bacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	2.5.1.105	ko:K04088,ko:K06897	ko00790,map00790	M00742	R10339	RC00121	ko00000,ko00001,ko00002,ko01000	-	-	-	Cation_efflux,ZT_dimer
SRR25158203_k127_1630472_3	196162.Noca_1618	2.746e-27	115.0	COG3224@1|root,COG3224@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09932	-	-	-	-	ko00000	-	-	-	ABM
SRR25158203_k127_1630472_1	868131.MSWAN_0873	1.12e-60	214.0	arCOG11509@1|root,arCOG11509@2157|Archaea,2Y3KG@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1630472_4	386456.JQKN01000013_gene3008	4.697e-24	104.0	COG0011@1|root,arCOG04373@2157|Archaea,2Y0PC@28890|Euryarchaeota,23P8H@183925|Methanobacteria	183925|Methanobacteria	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
SRR25158203_k127_1630472_2	1123371.ATXH01000022_gene985	3.076e-29	120.0	COG1235@1|root,COG1235@2|Bacteria,2GHT4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SRR25158203_k127_1648322_0	192952.MM_2028	1.095e-107	382.0	COG1413@1|root,arCOG00127@1|root,arCOG00127@2157|Archaea,arCOG02973@2157|Archaea,arCOG02974@2157|Archaea,2Y2I3@28890|Euryarchaeota,2NAKY@224756|Methanomicrobia	224756|Methanomicrobia	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
SRR25158203_k127_1648322_1	573063.Metin_0484	1.179e-86	318.0	COG0464@1|root,arCOG01307@2157|Archaea,2XTNA@28890|Euryarchaeota,23RUB@183939|Methanococci	183939|Methanococci	D	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Vps4_C
SRR25158203_k127_1650089_0	1094980.Mpsy_2899	2.97e-171	544.0	COG0119@1|root,arCOG02092@2157|Archaea,2XV8D@28890|Euryarchaeota,2N9F5@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the alpha-IPM synthase homocitrate synthase family	aksA	-	2.3.3.14	ko:K10977	ko00300,ko00620,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R00271,R08213,R08331,R08332	RC00004,RC00067,RC02149,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
SRR25158203_k127_1650089_4	269797.Mbar_A1596	2.73e-19	95.0	COG1592@1|root,arCOG01097@2157|Archaea,2XX3D@28890|Euryarchaeota,2NB3D@224756|Methanomicrobia	224756|Methanomicrobia	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SRR25158203_k127_1650089_1	192952.MM_0631	2.267e-40	153.0	COG0599@1|root,arCOG02148@2157|Archaea	2157|Archaea	S	PFAM Carboxymuconolactone decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
SRR25158203_k127_1650089_3	589924.Ferp_2513	3.662e-24	107.0	COG2193@1|root,arCOG01094@2157|Archaea,2Y22S@28890|Euryarchaeota	28890|Euryarchaeota	P	Ferritin-like domain	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SRR25158203_k127_1650089_2	351160.RCIX2061	1.767e-36	139.0	COG4056@1|root,arCOG03225@2157|Archaea,2XW32@28890|Euryarchaeota,2N9IH@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Methyl-coenzyme M reductase operon protein C	mcrC	-	-	ko:K03421	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	MCR_C
SRR25158203_k127_1654058_1	1173025.GEI7407_1016	8.72e-194	647.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1H8US@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_1654058_2	1220534.B655_2146	3.49e-10	65.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWKF@28890|Euryarchaeota,23P03@183925|Methanobacteria	183925|Methanobacteria	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
SRR25158203_k127_1654058_0	868131.MSWAN_1314	2.661e-219	702.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
SRR25158203_k127_1654058_3	604331.AUHY01000030_gene994	0.0006651	42.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
SRR25158203_k127_1664188_6	1345697.M493_08640	3.997e-23	103.0	COG1119@1|root,COG1119@2|Bacteria,1TRR4@1239|Firmicutes,4HB4U@91061|Bacilli,1WEMG@129337|Geobacillus	91061|Bacilli	P	ATPases associated with a variety of cellular activities	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
SRR25158203_k127_1664188_7	339860.Msp_0196	9.038e-16	91.0	COG0842@1|root,arCOG01463@2157|Archaea,2XVQJ@28890|Euryarchaeota,23NM6@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SRR25158203_k127_1664188_4	1101188.KI912155_gene3458	1.892e-68	243.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,1W7YN@1268|Micrococcaceae	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
SRR25158203_k127_1664188_2	1094980.Mpsy_1383	3.591e-136	440.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,2N944@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
SRR25158203_k127_1664188_3	644281.MFS40622_0126	1.573e-93	316.0	COG1775@1|root,arCOG04464@2157|Archaea	2157|Archaea	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
SRR25158203_k127_1664188_5	644281.MFS40622_0127	2.891e-49	184.0	COG1924@1|root,arCOG02678@2157|Archaea,2XVMQ@28890|Euryarchaeota	2157|Archaea	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	2.7.1.33	ko:K09680	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
SRR25158203_k127_1664188_8	1209989.TepiRe1_0084	2.034e-11	75.0	COG0265@1|root,COG0265@2|Bacteria,1TRQS@1239|Firmicutes,24E3C@186801|Clostridia,42FVK@68295|Thermoanaerobacterales	186801|Clostridia	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S7,Trypsin
SRR25158203_k127_1664188_1	1094980.Mpsy_0046	6.16e-198	625.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2N94I@224756|Methanomicrobia	224756|Methanomicrobia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SRR25158203_k127_1664188_0	1094980.Mpsy_1520	0.0	1250.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,2N92I@224756|Methanomicrobia	224756|Methanomicrobia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
SRR25158203_k127_1664188_9	696369.KI912183_gene1779	7.298e-06	50.0	COG3212@1|root,COG3212@2|Bacteria,1VJGF@1239|Firmicutes,24RQ9@186801|Clostridia,262RI@186807|Peptococcaceae	186801|Clostridia	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1669391_0	339860.Msp_0165	1.449e-25	121.0	COG2244@1|root,arCOG02209@2157|Archaea,2XVDT@28890|Euryarchaeota,23NPY@183925|Methanobacteria	183925|Methanobacteria	S	MviN-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
SRR25158203_k127_1671449_3	868131.MSWAN_0985	6.194e-23	101.0	COG2329@1|root,arCOG05403@2157|Archaea,2Y22C@28890|Euryarchaeota	28890|Euryarchaeota	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
SRR25158203_k127_1671449_2	1094980.Mpsy_1607	2.397e-49	183.0	COG0500@1|root,arCOG04989@2157|Archaea,2XYI7@28890|Euryarchaeota,2NBJ7@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR25158203_k127_1671449_0	269797.Mbar_A3501	3.829e-140	458.0	COG0351@1|root,arCOG00020@2157|Archaea,2XSW8@28890|Euryarchaeota,2N9G9@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Phosphomethylpyrimidine kinase type-1	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K21219	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
SRR25158203_k127_1671449_1	1123320.KB889731_gene6103	6.661e-54	199.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria	201174|Actinobacteria	KLT	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
SRR25158203_k127_1681163_6	269797.Mbar_A1730	1.083e-59	213.0	COG0726@1|root,arCOG02876@2157|Archaea,2XSWA@28890|Euryarchaeota	28890|Euryarchaeota	G	xylanase chitin deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
SRR25158203_k127_1681163_7	523850.TON_0814	3.884e-57	215.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUDX@28890|Euryarchaeota,243QJ@183968|Thermococci	183968|Thermococci	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_1681163_8	717772.THIAE_00365	8.12e-07	53.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RMA9@1236|Gammaproteobacteria,460PZ@72273|Thiotrichales	72273|Thiotrichales	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
SRR25158203_k127_1681163_1	484770.UFO1_1897	1.169e-125	411.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,4H3CY@909932|Negativicutes	909932|Negativicutes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
SRR25158203_k127_1681163_2	1280689.AUJC01000003_gene1284	1.887e-111	369.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,36E77@31979|Clostridiaceae	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
SRR25158203_k127_1681163_4	269797.Mbar_A0603	1.894e-84	287.0	COG1912@1|root,arCOG04309@2157|Archaea,2XUEW@28890|Euryarchaeota,2N9T8@224756|Methanomicrobia	224756|Methanomicrobia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
SRR25158203_k127_1681163_5	1094980.Mpsy_0986	2.407e-68	240.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,2N9KV@224756|Methanomicrobia	224756|Methanomicrobia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
SRR25158203_k127_1681163_3	1094980.Mpsy_2904	2.843e-100	334.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,2N97C@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
SRR25158203_k127_1681163_0	192952.MM_2004	1.122e-315	990.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,2N9IK@224756|Methanomicrobia	224756|Methanomicrobia	L	SMART DNA-directed DNA polymerase B	polB-1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
SRR25158203_k127_1697092_19	1094980.Mpsy_1103	9.681e-46	182.0	COG0582@1|root,arCOG01245@2157|Archaea,2XZM9@28890|Euryarchaeota,2NAT1@224756|Methanomicrobia	224756|Methanomicrobia	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
SRR25158203_k127_1697092_29	47839.CCAU010000004_gene1043	4.336e-22	100.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRR25158203_k127_1697092_22	269797.Mbar_A2000	2.908e-36	141.0	COG3613@1|root,arCOG02434@2157|Archaea,2XZZI@28890|Euryarchaeota,2NBK5@224756|Methanomicrobia	224756|Methanomicrobia	F	Nucleoside 2-deoxyribosyltransferase like	-	-	2.4.2.6	ko:K08728	ko00240,map00240	-	R02806	RC00063	ko00000,ko00001,ko01000	-	-	-	Nuc_deoxyrib_tr
SRR25158203_k127_1697092_31	693661.Arcve_1513	4.399e-15	76.0	arCOG11553@1|root,arCOG11553@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1697092_14	593750.Metfor_2209	5.756e-59	213.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota	28890|Euryarchaeota	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
SRR25158203_k127_1697092_6	192952.MM_0254	2.48e-87	296.0	COG4002@1|root,arCOG00854@2157|Archaea,2XVHH@28890|Euryarchaeota,2NBJX@224756|Methanomicrobia	224756|Methanomicrobia	S	methyltransferase activity	mtxX	-	-	-	-	-	-	-	-	-	-	-	PTA_PTB
SRR25158203_k127_1697092_5	1094980.Mpsy_2072	5.25e-90	304.0	COG0345@1|root,arCOG00455@2157|Archaea,2XTJT@28890|Euryarchaeota,2NA0F@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
SRR25158203_k127_1697092_23	1094980.Mpsy_1862	5.819e-34	133.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,2NA0G@224756|Methanomicrobia	224756|Methanomicrobia	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
SRR25158203_k127_1697092_24	192952.MM_2016	2.059e-30	123.0	COG0316@1|root,arCOG04560@2157|Archaea,2XXWU@28890|Euryarchaeota,2NA1P@224756|Methanomicrobia	224756|Methanomicrobia	O	Iron-sulphur cluster biosynthesis	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
SRR25158203_k127_1697092_27	269797.Mbar_A2451	2.387e-24	105.0	arCOG04419@1|root,arCOG04419@2157|Archaea,2XZTP@28890|Euryarchaeota,2N9ZJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2551)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2551
SRR25158203_k127_1697092_20	243232.MJ_0778	2.907e-43	164.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota,23R1B@183939|Methanococci	183939|Methanococci	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SRR25158203_k127_1697092_13	192952.MM_0692	1.679e-59	210.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2N9WY@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
SRR25158203_k127_1697092_7	192952.MM_0691	3.314e-83	289.0	COG2232@1|root,arCOG01595@2157|Archaea,2XXHX@28890|Euryarchaeota,2N9KN@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
SRR25158203_k127_1697092_10	1094980.Mpsy_0110	6.681e-68	236.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,2N9MS@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
SRR25158203_k127_1697092_3	192952.MM_3078	2.205e-145	471.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,2N974@224756|Methanomicrobia	224756|Methanomicrobia	J	Beta-Casp domain	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
SRR25158203_k127_1697092_2	521011.Mpal_1153	5.655e-168	535.0	COG0436@1|root,arCOG01130@2157|Archaea,2XVI8@28890|Euryarchaeota,2NBGE@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
SRR25158203_k127_1697092_16	269797.Mbar_A2071	4.272e-57	203.0	COG0426@1|root,arCOG00509@2157|Archaea,2XYDW@28890|Euryarchaeota,2N9PY@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
SRR25158203_k127_1697092_12	118161.KB235922_gene4388	1.164e-65	235.0	COG2890@1|root,COG2890@2|Bacteria,1G6DS@1117|Cyanobacteria	1117|Cyanobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRR25158203_k127_1697092_18	269797.Mbar_A2954	9.363e-47	173.0	COG4740@1|root,arCOG04821@2157|Archaea,2XZIV@28890|Euryarchaeota,2NB0K@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
SRR25158203_k127_1697092_21	368407.Memar_2333	9.081e-40	152.0	COG0494@1|root,arCOG01078@2157|Archaea,2XWMW@28890|Euryarchaeota	28890|Euryarchaeota	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	apa	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SRR25158203_k127_1697092_11	330779.Saci_0159	5.087e-67	233.0	COG1573@1|root,arCOG00905@2157|Archaea,2XQ7T@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SRR25158203_k127_1697092_0	1094980.Mpsy_2859	1.885e-252	791.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,2N96H@224756|Methanomicrobia	224756|Methanomicrobia	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
SRR25158203_k127_1697092_26	1041930.Mtc_0771	1.343e-25	110.0	COG4738@1|root,arCOG04377@2157|Archaea,2XYIC@28890|Euryarchaeota,2NBJG@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1697092_9	192952.MM_2464	8.717e-69	235.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2N9MF@224756|Methanomicrobia	224756|Methanomicrobia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iAF692.Mbar_A3385	NDK
SRR25158203_k127_1697092_28	679926.Mpet_2106	7.816e-24	101.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,2NA03@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
SRR25158203_k127_1697092_25	1094980.Mpsy_2862	1.327e-29	118.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,2N9ZH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
SRR25158203_k127_1697092_17	1041930.Mtc_1910	1.076e-51	185.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2N9WX@224756|Methanomicrobia	224756|Methanomicrobia	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
SRR25158203_k127_1697092_30	192952.MM_0716	1.091e-17	93.0	arCOG04912@1|root,arCOG04912@2157|Archaea,2Y3SP@28890|Euryarchaeota,2NAWD@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1697092_4	1094980.Mpsy_2049	2.764e-126	414.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,2N9AU@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
SRR25158203_k127_1697092_15	1094980.Mpsy_2048	1.399e-58	210.0	COG0135@1|root,arCOG01983@2157|Archaea,2XXCM@28890|Euryarchaeota,2NBIJ@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
SRR25158203_k127_1697092_1	1094980.Mpsy_2047	6.761e-188	599.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,2N9A9@224756|Methanomicrobia	224756|Methanomicrobia	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
SRR25158203_k127_1697092_8	1094980.Mpsy_2046	2.78e-78	265.0	COG0512@1|root,arCOG00086@2157|Archaea,2XTES@28890|Euryarchaeota,2N9PV@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SRR25158203_k127_1704730_1	1459636.NTE_03124	3.214e-19	96.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
SRR25158203_k127_1704730_0	472759.Nhal_3185	3.946e-277	865.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,1X0CY@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
SRR25158203_k127_1704730_2	679926.Mpet_2551	1.892e-17	83.0	arCOG10446@1|root,arCOG10446@2157|Archaea,2Y1MQ@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
SRR25158203_k127_1705034_1	387631.Asulf_00088	1.022e-17	98.0	COG0614@1|root,arCOG03439@1|root,arCOG03439@2157|Archaea,arCOG03611@2157|Archaea,2XXWR@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
SRR25158203_k127_1705034_0	589924.Ferp_0234	6.1e-73	261.0	COG1404@1|root,arCOG00702@2157|Archaea,2XSZR@28890|Euryarchaeota,2478R@183980|Archaeoglobi	28890|Euryarchaeota	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	3.4.21.62	ko:K01342,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PKD,Peptidase_S8
SRR25158203_k127_1707829_13	387631.Asulf_01282	2.456e-27	124.0	COG1750@1|root,arCOG01937@2157|Archaea,2XUEB@28890|Euryarchaeota,245RX@183980|Archaeoglobi	183980|Archaeoglobi	O	Belongs to the peptidase S16 family	-	-	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
SRR25158203_k127_1707829_7	593750.Metfor_1707	2.343e-107	351.0	COG0463@1|root,arCOG01386@2157|Archaea,2Y7Y7@28890|Euryarchaeota,2NBN5@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR25158203_k127_1707829_6	368407.Memar_1077	1.006e-117	387.0	COG0438@1|root,arCOG01407@2157|Archaea,2XUJ8@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0438 Glycosyltransferase	gth2	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_1707829_2	368407.Memar_1076	1.841e-199	629.0	COG1232@1|root,arCOG01522@2157|Archaea,2XY37@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SRR25158203_k127_1707829_15	469618.FVAG_00946	6.892e-21	99.0	COG0671@1|root,COG0671@2|Bacteria,37AUG@32066|Fusobacteria	32066|Fusobacteria	I	Psort location CytoplasmicMembrane, score	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SRR25158203_k127_1707829_11	1173028.ANKO01000044_gene805	3.519e-35	136.0	COG1669@1|root,COG1669@2|Bacteria,1G804@1117|Cyanobacteria,1HCHE@1150|Oscillatoriales	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_1707829_17	102232.GLO73106DRAFT_00039500	7.366e-20	93.0	COG2361@1|root,COG2361@2|Bacteria,1G7XA@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG2361 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SRR25158203_k127_1707829_18	402777.KB235903_gene647	1.235e-10	63.0	COG2361@1|root,COG2361@2|Bacteria,1G7XA@1117|Cyanobacteria,1HCYZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SRR25158203_k127_1707829_16	589924.Ferp_2212	6.548e-20	91.0	COG1977@1|root,arCOG00536@2157|Archaea,2Y7D4@28890|Euryarchaeota,246JE@183980|Archaeoglobi	183980|Archaeoglobi	H	Urm1 (Ubiquitin related modifier)	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SRR25158203_k127_1707829_3	589924.Ferp_2213	1.184e-165	530.0	COG0498@1|root,arCOG01434@2157|Archaea,2XTNY@28890|Euryarchaeota,245TE@183980|Archaeoglobi	183980|Archaeoglobi	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRR25158203_k127_1707829_5	269797.Mbar_A1789	2.599e-128	416.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
SRR25158203_k127_1707829_1	192952.MM_0087	1.354e-218	688.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,2N9C6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	deoA	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,Molydop_binding,PYNP_C
SRR25158203_k127_1707829_14	593750.Metfor_2530	2.704e-27	126.0	arCOG09579@1|root,arCOG09579@2157|Archaea,2Y58J@28890|Euryarchaeota,2NBAR@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1707829_8	593750.Metfor_2531	3.405e-77	268.0	arCOG00381@1|root,arCOG00381@2157|Archaea,2XV0K@28890|Euryarchaeota	28890|Euryarchaeota	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1707829_10	1094980.Mpsy_1420	1.244e-61	219.0	COG0169@1|root,arCOG02097@2157|Archaea,2XWH4@28890|Euryarchaeota,2N9XM@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
SRR25158203_k127_1707829_0	1094980.Mpsy_0254	9.34e-276	870.0	COG1202@1|root,arCOG00554@2157|Archaea,arCOG03143@2157|Archaea,2XUCK@28890|Euryarchaeota,2N92E@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
SRR25158203_k127_1707829_4	192952.MM_1963	4.614e-144	464.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,2N98T@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
SRR25158203_k127_1707829_9	545694.TREPR_2179	2.598e-64	229.0	COG4231@1|root,COG4231@2|Bacteria	2|Bacteria	C	indolepyruvate ferredoxin oxidoreductase activity	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,Pyr_redox_2
SRR25158203_k127_1707829_12	696281.Desru_2672	5.214e-32	126.0	2DNPA@1|root,32YE5@2|Bacteria,1UJKC@1239|Firmicutes,25F58@186801|Clostridia,266CI@186807|Peptococcaceae	186801|Clostridia	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
SRR25158203_k127_1707829_19	456442.Mboo_0404	0.000316	44.0	arCOG11378@1|root,arCOG11378@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_170983_0	489825.LYNGBM3L_41950	7.59e-89	311.0	COG0467@1|root,COG0467@2|Bacteria,1G2XC@1117|Cyanobacteria,1H8VM@1150|Oscillatoriales	1117|Cyanobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SRR25158203_k127_170983_5	1041930.Mtc_1242	0.0009685	48.0	arCOG13256@1|root,arCOG13256@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_170983_2	1094980.Mpsy_2344	1.908e-47	173.0	COG0745@1|root,arCOG02595@2157|Archaea,2XZSB@28890|Euryarchaeota,2NAXV@224756|Methanomicrobia	224756|Methanomicrobia	T	cheY-homologous receiver domain	-	-	-	ko:K07668	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SRR25158203_k127_170983_3	247490.KSU1_B0201	4.113e-39	169.0	COG4191@1|root,COG4191@2|Bacteria,2J2CV@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
SRR25158203_k127_170983_1	1094980.Mpsy_0872	6.261e-73	279.0	COG0642@1|root,arCOG07619@2157|Archaea,2Y7TB@28890|Euryarchaeota	28890|Euryarchaeota	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_9,sCache_3_3
SRR25158203_k127_170983_4	593750.Metfor_1083	3.9e-11	66.0	COG1082@1|root,arCOG01897@2157|Archaea,2XWQA@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SRR25158203_k127_1738637_3	272134.KB731324_gene2703	7.21e-17	82.0	COG1508@1|root,COG1508@2|Bacteria,1G2GU@1117|Cyanobacteria,1HA33@1150|Oscillatoriales	1117|Cyanobacteria	K	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1738637_0	269797.Mbar_A3472	7.476e-280	877.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,2N92F@224756|Methanomicrobia	224756|Methanomicrobia	L	acid binding OB-fold tRNA helicase-type	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DnaJ_CXXCXGXG,S1,tRNA_anti-codon
SRR25158203_k127_1738637_4	1094980.Mpsy_2561	1.318e-14	74.0	COG1145@1|root,arCOG02060@2157|Archaea,2Y6W3@28890|Euryarchaeota,2NA34@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SRR25158203_k127_1738637_1	1094980.Mpsy_2560	3.38e-136	444.0	COG1233@1|root,arCOG01521@2157|Archaea,2XUA0@28890|Euryarchaeota,2N96Y@224756|Methanomicrobia	224756|Methanomicrobia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
SRR25158203_k127_1738637_2	511051.CSE_03160	9.013e-30	123.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SRR25158203_k127_1739056_5	589924.Ferp_1127	2.081e-32	127.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,246B9@183980|Archaeoglobi	183980|Archaeoglobi	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
SRR25158203_k127_1739056_4	452637.Oter_0845	5.235e-34	143.0	COG2864@1|root,COG3005@1|root,COG2864@2|Bacteria,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1
SRR25158203_k127_1739056_3	1167006.UWK_00557	1.694e-47	179.0	COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,42NQM@68525|delta/epsilon subdivisions,2WK76@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
SRR25158203_k127_1739056_2	1459636.NTE_03043	1.169e-93	319.0	COG1899@1|root,arCOG04142@2157|Archaea,41SWS@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SRR25158203_k127_1739056_0	1094980.Mpsy_1422	5.52e-167	537.0	COG0722@1|root,arCOG00245@2157|Archaea,2XU8C@28890|Euryarchaeota,2N9HG@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
SRR25158203_k127_1739056_1	1094980.Mpsy_1421	5.661e-106	349.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,2N9IF@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,2.7.1.71,4.2.1.10	ko:K00014,ko:K00891,ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R02413,R03084	RC00002,RC00078,RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0923	SKI,Shikimate_DH,Shikimate_dh_N
SRR25158203_k127_1743096_1	1094980.Mpsy_0413	7.808e-239	771.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRR25158203_k127_1743096_2	1094980.Mpsy_0414	3.554e-235	744.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2N93G@224756|Methanomicrobia	224756|Methanomicrobia	N	type II secretion system protein	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SRR25158203_k127_1743096_0	926561.KB900617_gene1960	1.429e-271	848.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,3WACS@53433|Halanaerobiales	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
SRR25158203_k127_1743096_5	246969.TAM4_1862	9.652e-20	93.0	COG1487@1|root,arCOG02219@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
SRR25158203_k127_1743096_3	768706.Desor_2586	6.43e-69	240.0	COG0778@1|root,COG0778@2|Bacteria,1V6AG@1239|Firmicutes,2515F@186801|Clostridia,266PU@186807|Peptococcaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRR25158203_k127_1743096_6	1054217.TALC_00574	2.445e-13	78.0	COG3413@1|root,arCOG02271@2157|Archaea	2157|Archaea	S	Bacterio-opsin activator HTH	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
SRR25158203_k127_1743096_4	1094980.Mpsy_2247	4.898e-24	102.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR25158203_k127_1747974_9	1041930.Mtc_1366	1.071e-47	175.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,2N9XB@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
SRR25158203_k127_1747974_2	1173027.Mic7113_2936	1.62e-176	563.0	COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria,1H75A@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
SRR25158203_k127_1747974_0	237368.SCABRO_00111	3.579e-274	860.0	COG1331@1|root,COG1331@2|Bacteria,2IX0N@203682|Planctomycetes	203682|Planctomycetes	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
SRR25158203_k127_1747974_8	1094980.Mpsy_1154	1.61e-58	215.0	COG1361@1|root,arCOG02086@2157|Archaea,2Y7NE@28890|Euryarchaeota,2NA14@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1747974_7	868131.MSWAN_0027	1.599e-60	223.0	COG0842@1|root,arCOG01463@2157|Archaea,2XVQJ@28890|Euryarchaeota,23NM6@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SRR25158203_k127_1747974_6	1121472.AQWN01000010_gene532	1.771e-67	239.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,2611J@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
SRR25158203_k127_1747974_5	1094980.Mpsy_2709	2.226e-68	242.0	COG1587@1|root,arCOG02048@2157|Archaea,2XTA1@28890|Euryarchaeota,2NBJR@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
SRR25158203_k127_1747974_3	269797.Mbar_A1791	4.806e-119	386.0	COG0007@1|root,arCOG00644@2157|Archaea,2XTE1@28890|Euryarchaeota,2N96Z@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cobA	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
SRR25158203_k127_1747974_4	1094980.Mpsy_2487	1.311e-103	346.0	COG0181@1|root,arCOG04299@2157|Archaea,2XTBP@28890|Euryarchaeota,2N97F@224756|Methanomicrobia	224756|Methanomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1465	Porphobil_deam,Porphobil_deamC
SRR25158203_k127_1747974_1	192952.MM_1743	2.453e-199	627.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,2N937@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SRR25158203_k127_174803_12	579137.Metvu_0844	7.002e-69	245.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,23QJ2@183939|Methanococci	183939|Methanococci	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
SRR25158203_k127_174803_0	1123514.KB905900_gene2162	4.207e-301	936.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales	72273|Thiotrichales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
SRR25158203_k127_174803_7	306281.AJLK01000190_gene1658	3.894e-89	306.0	COG0438@1|root,COG0438@2|Bacteria,1G0Z5@1117|Cyanobacteria,1JJW6@1189|Stigonemataceae	1117|Cyanobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_174803_5	1094980.Mpsy_0357	2.218e-118	386.0	COG4022@1|root,arCOG04893@2157|Archaea,2XVN1@28890|Euryarchaeota,2N9I3@224756|Methanomicrobia	224756|Methanomicrobia	S	Methanogenesis marker protein 8	-	-	-	-	-	-	-	-	-	-	-	-	DUF2099
SRR25158203_k127_174803_21	1094980.Mpsy_1565	3.439e-15	80.0	arCOG04995@1|root,arCOG04995@2157|Archaea,2Y7CS@28890|Euryarchaeota,2NB80@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_174803_22	1041930.Mtc_2132	3.201e-14	76.0	arCOG07113@1|root,arCOG07113@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	QueC,TBP
SRR25158203_k127_174803_2	273063.STK_13870	5.494e-168	541.0	COG0174@1|root,arCOG01909@2157|Archaea,2XPM9@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Glutamine synthetase, catalytic	glnA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SRR25158203_k127_174803_1	1094980.Mpsy_1369	2.22e-187	594.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,2N98P@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SRR25158203_k127_174803_6	1094980.Mpsy_1335	3.04e-112	371.0	COG1693@1|root,arCOG02710@2157|Archaea,2XVGZ@28890|Euryarchaeota,2N90G@224756|Methanomicrobia	224756|Methanomicrobia	K	Ribonuclease R winged-helix domain	-	-	-	ko:K09720	-	-	-	-	ko00000,ko03000	-	-	-	DUF128,HTH_12
SRR25158203_k127_174803_9	868131.MSWAN_1817	2.182e-76	257.0	COG5485@1|root,arCOG06513@2157|Archaea,2Y3E5@28890|Euryarchaeota	28890|Euryarchaeota	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
SRR25158203_k127_174803_16	1094980.Mpsy_2563	5.226e-49	178.0	COG1417@1|root,arCOG04850@2157|Archaea	2157|Archaea	S	to GB L77117 SP Q58031 PID 1591324 percent identity	-	-	-	-	-	-	-	-	-	-	-	-	DUF22
SRR25158203_k127_174803_15	1094980.Mpsy_2564	1.636e-51	188.0	arCOG10371@1|root,arCOG10371@2157|Archaea,2Y5QH@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_174803_17	1121413.JMKT01000002_gene2641	1.31e-44	166.0	COG0655@1|root,COG0655@2|Bacteria,1QV9P@1224|Proteobacteria,42RJT@68525|delta/epsilon subdivisions,2WNM5@28221|Deltaproteobacteria,2MGKQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Flavodoxin domain	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
SRR25158203_k127_174803_11	269797.Mbar_A1043	6.915e-71	251.0	COG1073@1|root,arCOG01654@2157|Archaea,2Y0NH@28890|Euryarchaeota,2NA0N@224756|Methanomicrobia	224756|Methanomicrobia	S	Acetyl xylan esterase (AXE1)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	AXE1,Hydrolase_4
SRR25158203_k127_174803_3	933801.Ahos_0309	2.226e-125	413.0	COG1960@1|root,arCOG04310@2157|Archaea,2XPUV@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRR25158203_k127_174803_23	1267533.KB906734_gene4076	4.427e-06	54.0	COG0491@1|root,COG0491@2|Bacteria,3Y3M4@57723|Acidobacteria,2JI7X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRR25158203_k127_174803_4	247490.KSU1_C0204	4.689e-124	404.0	COG1250@1|root,COG1250@2|Bacteria,2IYGX@203682|Planctomycetes	203682|Planctomycetes	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3	ko:K00074,ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
SRR25158203_k127_174803_10	273068.TTE0544	3.747e-72	252.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
SRR25158203_k127_174803_19	391623.TERMP_01338	9.201e-36	151.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,242SB@183968|Thermococci	183968|Thermococci	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_174803_14	1291050.JAGE01000001_gene160	4.027e-65	235.0	COG0535@1|root,COG0535@2|Bacteria,1UXWS@1239|Firmicutes,247NG@186801|Clostridia	186801|Clostridia	C	Radical SAM	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SRR25158203_k127_174803_8	192952.MM_2100	6.982e-78	269.0	COG2120@1|root,arCOG03460@2157|Archaea	2157|Archaea	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SRR25158203_k127_174803_20	192952.MM_1142	1.922e-34	148.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,2N9R4@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_174803_13	70601.3257229	2.829e-68	250.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,243ZB@183968|Thermococci	183968|Thermococci	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR25158203_k127_174803_18	1198232.CYCME_1450	9.133e-43	171.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,1RXH8@1236|Gammaproteobacteria,4633T@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_1765618_2	679926.Mpet_0363	1.22e-06	57.0	arCOG02421@1|root,arCOG02421@2157|Archaea	679926.Mpet_0363|-	S	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1765618_1	485913.Krac_8043	2.401e-16	80.0	28SF2@1|root,2ZERN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1765618_0	880073.Calab_2261	4.408e-191	617.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,2NNZ0@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefC	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
SRR25158203_k127_1770338_6	192952.MM_3299	1.045e-16	81.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
SRR25158203_k127_1770338_5	351160.LRC27	6.721e-57	202.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,2N9QF@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
SRR25158203_k127_1770338_4	1094980.Mpsy_1497	1.977e-67	234.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2N9MV@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
SRR25158203_k127_1770338_8	1094980.Mpsy_1496	1.774e-14	74.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y188@28890|Euryarchaeota,2NA63@224756|Methanomicrobia	224756|Methanomicrobia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
SRR25158203_k127_1770338_0	1094980.Mpsy_2713	0.0	1233.0	COG0423@1|root,COG0525@1|root,arCOG00405@2157|Archaea,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
SRR25158203_k127_1770338_2	342949.PNA2_1583	1.817e-77	267.0	COG1635@1|root,arCOG00574@2157|Archaea,2XTXH@28890|Euryarchaeota,2437Q@183968|Thermococci	183968|Thermococci	H	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur	-	-	-	ko:K03146	ko00730,ko01100,map00730,map01100	-	R10685	RC00033,RC03253,RC03254	ko00000,ko00001	-	-	-	Thi4
SRR25158203_k127_1770338_7	472759.Nhal_1702	1.215e-14	76.0	COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1TKC3@1236|Gammaproteobacteria,1X1RM@135613|Chromatiales	135613|Chromatiales	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
SRR25158203_k127_1770338_1	269797.Mbar_A1752	2.104e-192	610.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
SRR25158203_k127_1770338_3	864051.BurJ1DRAFT_3878	4.988e-75	267.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria	1224|Proteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
SRR25158203_k127_1781169_1	1094980.Mpsy_1929	1.052e-30	121.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,2N920@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Semialdehyde dehydrogenase NAD - binding	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SRR25158203_k127_1781169_4	573064.Mefer_0148	5.304e-20	102.0	COG0628@1|root,arCOG02642@2157|Archaea,2XT00@28890|Euryarchaeota,23Q5W@183939|Methanococci	183939|Methanococci	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
SRR25158203_k127_1781169_2	192952.MM_2151	2.162e-23	101.0	COG0663@1|root,arCOG01849@2157|Archaea,2Y0WS@28890|Euryarchaeota,2NAR5@224756|Methanomicrobia	224756|Methanomicrobia	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
SRR25158203_k127_1781169_3	192952.MM_0911	2.617e-23	104.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-1	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
SRR25158203_k127_1781169_0	269797.Mbar_A0707	4.643e-31	124.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-1	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
SRR25158203_k127_1782066_4	565033.GACE_1433	1.229e-06	52.0	COG2026@1|root,arCOG02414@2157|Archaea,2Y4R0@28890|Euryarchaeota,247CT@183980|Archaeoglobi	183980|Archaeoglobi	K	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
SRR25158203_k127_1782066_1	391625.PPSIR1_06858	1.967e-25	119.0	COG2385@1|root,COG2385@2|Bacteria	2|Bacteria	D	sporulation resulting in formation of a cellular spore	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Amidase_2,Amidase_3,ChW,SpoIID
SRR25158203_k127_1782066_5	1382306.JNIM01000001_gene1500	1.817e-06	60.0	COG3325@1|root,COG3469@1|root,COG3325@2|Bacteria,COG3469@2|Bacteria	2|Bacteria	G	chitinase activity	-	-	3.2.1.14,3.2.1.17	ko:K01183,ko:K13381	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	CBM15,GH18	-	CBM_2,CBM_4_9,CBM_5_12,Glyco_hydro_18,Glyco_hydro_64,fn3
SRR25158203_k127_1782066_0	192952.MM_2862	2.502e-101	338.0	COG4022@1|root,arCOG04893@2157|Archaea,2XVN1@28890|Euryarchaeota,2N9I3@224756|Methanomicrobia	224756|Methanomicrobia	S	Methanogenesis marker protein 8	-	-	-	-	-	-	-	-	-	-	-	-	DUF2099
SRR25158203_k127_1782066_2	290402.Cbei_0627	6.865e-24	105.0	COG1433@1|root,COG1433@2|Bacteria,1VEGH@1239|Firmicutes,24RHJ@186801|Clostridia,36JAI@31979|Clostridiaceae	186801|Clostridia	S	PFAM Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
SRR25158203_k127_1782570_3	1262449.CP6013_3868	9.117e-46	180.0	COG0297@1|root,COG0297@2|Bacteria,1UHYC@1239|Firmicutes,24ANR@186801|Clostridia,36G27@31979|Clostridiaceae	186801|Clostridia	G	glycosyl transferase group 1	-	-	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_1782570_5	1121403.AUCV01000032_gene2916	1.224e-18	98.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42UH1@68525|delta/epsilon subdivisions,2WQ2J@28221|Deltaproteobacteria,2MPY2@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_1782570_1	1289135.A966_09932	3.51e-105	358.0	COG1032@1|root,COG1032@2|Bacteria,2J9G9@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR25158203_k127_1782570_2	391623.TERMP_01739	2.432e-71	249.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
SRR25158203_k127_1782570_6	572546.Arcpr_0076	2.714e-08	61.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y1J3@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SRR25158203_k127_1782570_4	351160.RCIX2338	7.88e-29	122.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
SRR25158203_k127_1782570_0	192952.MM_2931	2.686e-140	458.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota,2N97K@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
SRR25158203_k127_1782570_7	485913.Krac_8476	0.0003676	45.0	COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi	200795|Chloroflexi	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRR25158203_k127_1793400_3	1094980.Mpsy_1809	2.155e-63	223.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2N9QR@224756|Methanomicrobia	224756|Methanomicrobia	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRR25158203_k127_1793400_0	1094980.Mpsy_1642	1.467e-296	923.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,2N99D@224756|Methanomicrobia	224756|Methanomicrobia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
SRR25158203_k127_1793400_1	1094980.Mpsy_0899	1.766e-178	566.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9G4@224756|Methanomicrobia	224756|Methanomicrobia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.6.1.108	ko:K19793	ko00680,map00680	-	R11038	RC00008,RC00048	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1546	Aminotran_1_2
SRR25158203_k127_1793400_4	342949.PNA2_0988	1.342e-28	130.0	COG1373@1|root,arCOG03167@2157|Archaea,2XW6H@28890|Euryarchaeota,2437E@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SRR25158203_k127_1793400_2	383372.Rcas_1737	1.972e-127	413.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GAC0@200795|Chloroflexi,376BQ@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
SRR25158203_k127_180313_0	1094980.Mpsy_2382	5.786e-305	945.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
SRR25158203_k127_180313_2	1094980.Mpsy_0336	5.777e-142	455.0	COG0040@1|root,arCOG02208@2157|Archaea,2Y2ZH@28890|Euryarchaeota,2NA8F@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
SRR25158203_k127_180313_3	192952.MM_1592	2.498e-105	350.0	COG1907@1|root,arCOG01026@2157|Archaea,2XUFK@28890|Euryarchaeota,2N92U@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P)	-	-	2.4.2.54	ko:K06984	ko00790,map00790	-	R10337,R11102	-	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0806	DUF98,GHMP_kinases_C,GHMP_kinases_N
SRR25158203_k127_180313_1	269797.Mbar_A1431	9.756e-210	664.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9CA@224756|Methanomicrobia	224756|Methanomicrobia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
SRR25158203_k127_180313_5	118168.MC7420_6252	0.0002028	49.0	COG2018@1|root,COG2018@2|Bacteria,1G7A5@1117|Cyanobacteria,1HBQ8@1150|Oscillatoriales	1117|Cyanobacteria	S	Roadblock LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SRR25158203_k127_180313_4	436308.Nmar_1463	1.441e-37	144.0	COG3324@1|root,arCOG04946@2157|Archaea	436308.Nmar_1463|-	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
SRR25158203_k127_181420_0	1094980.Mpsy_0969	7.007e-182	576.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,2N93K@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
SRR25158203_k127_181420_7	1094980.Mpsy_0970	5.323e-34	134.0	COG1412@1|root,arCOG04312@2157|Archaea,2XX55@28890|Euryarchaeota,2N9V2@224756|Methanomicrobia	224756|Methanomicrobia	V	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
SRR25158203_k127_181420_2	269797.Mbar_A0285	3.659e-75	259.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,2N9GJ@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
SRR25158203_k127_181420_8	304371.MCP_2674	5.006e-20	91.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,2NA1J@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
SRR25158203_k127_181420_5	1094980.Mpsy_0973	6.277e-51	186.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2N9R8@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
SRR25158203_k127_181420_11	192952.MM_0599	1.218e-17	88.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,2NA0E@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
SRR25158203_k127_181420_9	192952.MM_0600	6.671e-19	86.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,2NA60@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
SRR25158203_k127_181420_10	192952.MM_2919	9.89e-19	89.0	COG0599@1|root,arCOG02151@2157|Archaea,2Y0W0@28890|Euryarchaeota,2NB47@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_181420_3	192952.MM_1111	2.744e-70	243.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2N9Y8@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
SRR25158203_k127_181420_6	192952.MM_0342	2.29e-44	164.0	COG0432@1|root,arCOG04214@2157|Archaea,2XXSW@28890|Euryarchaeota,2NATS@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
SRR25158203_k127_181420_1	1094980.Mpsy_1894	5.278e-180	571.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,2N9CD@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
SRR25158203_k127_181420_4	269797.Mbar_A1006	4.321e-70	242.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,2N9E5@224756|Methanomicrobia	224756|Methanomicrobia	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
SRR25158203_k127_1844647_6	304371.MCP_0514	1.38e-26	112.0	COG4056@1|root,arCOG03225@2157|Archaea,2XW32@28890|Euryarchaeota,2N9IH@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Methyl-coenzyme M reductase operon protein C	mcrC	-	-	ko:K03421	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	MCR_C
SRR25158203_k127_1844647_7	269797.Mbar_A2452	9.263e-26	108.0	COG4855@1|root,arCOG02570@2157|Archaea,2Y11K@28890|Euryarchaeota,2NA57@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2180
SRR25158203_k127_1844647_9	1220534.B655_0553	8.197e-18	85.0	COG4855@1|root,arCOG02570@2157|Archaea,2Y11K@28890|Euryarchaeota,23PRY@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized protein conserved in archaea (DUF2180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2180
SRR25158203_k127_1844647_3	186497.PF0971	5.255e-58	213.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,243DZ@183968|Thermococci	183968|Thermococci	C	pyruvate synthase activity	porG	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SRR25158203_k127_1844647_10	926561.KB900617_gene2306	2.552e-17	93.0	COG1144@1|root,COG1144@2|Bacteria,1VAAJ@1239|Firmicutes,24NFD@186801|Clostridia,3WC0G@53433|Halanaerobiales	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
SRR25158203_k127_1844647_1	673860.AciM339_1068	2.023e-116	387.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,3F2FU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SRR25158203_k127_1844647_2	673860.AciM339_0763	8.02e-89	302.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,3F2JH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	vorB	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SRR25158203_k127_1844647_8	177437.HRM2_41070	1.935e-20	93.0	COG0695@1|root,COG0695@2|Bacteria,1NAZM@1224|Proteobacteria,42VIA@68525|delta/epsilon subdivisions,2WR8X@28221|Deltaproteobacteria,2MKPI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM Glutaredoxin	-	-	-	ko:K06191	-	-	-	-	ko00000	-	-	-	Glutaredoxin
SRR25158203_k127_1844647_4	593750.Metfor_2107	4.402e-46	171.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota,2NAWN@224756|Methanomicrobia	224756|Methanomicrobia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
SRR25158203_k127_1844647_0	351160.LRC174	7.407e-120	392.0	COG4052@1|root,arCOG03226@2157|Archaea,2XTWG@28890|Euryarchaeota,2N9D6@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogenesis marker protein 7	-	-	-	-	-	-	-	-	-	-	-	-	MCR_C
SRR25158203_k127_1844647_5	304371.MCP_1064	3.478e-38	150.0	COG4051@1|root,arCOG04904@2157|Archaea,2Y0XT@28890|Euryarchaeota,2N9XA@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2113)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2113
SRR25158203_k127_1882300_8	644282.Deba_2983	1.229e-14	83.0	COG2181@1|root,COG3005@1|root,COG2181@2|Bacteria,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	ywjF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Nitrate_red_gam
SRR25158203_k127_1882300_1	192952.MM_1844	3.051e-190	604.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,2N92Q@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
SRR25158203_k127_1882300_4	1122176.KB903538_gene1453	1.211e-63	236.0	COG1032@1|root,COG1032@2|Bacteria,4NH8Y@976|Bacteroidetes,1IRE5@117747|Sphingobacteriia	2|Bacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR25158203_k127_1882300_7	1220534.B655_0733	7.207e-25	108.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
SRR25158203_k127_1882300_5	224325.AF_0648	3.623e-39	159.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUCU@28890|Euryarchaeota,245TP@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1882300_2	368407.Memar_0659	2.381e-123	402.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N9HU@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
SRR25158203_k127_1882300_3	368407.Memar_0658	1.788e-92	310.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
SRR25158203_k127_1882300_6	192952.MM_1906	2.065e-29	120.0	arCOG03597@1|root,arCOG03597@2157|Archaea,2Y60H@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
SRR25158203_k127_1882300_0	1220534.B655_1026	1.705e-216	683.0	COG0069@1|root,arCOG03896@1|root,arCOG00619@2157|Archaea,arCOG03896@2157|Archaea,2Y7H6@28890|Euryarchaeota,23PHC@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the glutamate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769,Glu_synthase
SRR25158203_k127_1892762_3	1049564.TevJSym_af00950	2.869e-30	139.0	COG0745@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria	1224|Proteobacteria	T	GAF domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Pkinase,STAS,SpoIIE
SRR25158203_k127_1892762_0	351160.RCIX2113	2.053e-80	297.0	COG0784@1|root,arCOG03799@1|root,arCOG06712@1|root,arCOG02393@2157|Archaea,arCOG03799@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Anticodon_1,DUF835,GAF_2,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_9,Response_reg,zinc_ribbon_2
SRR25158203_k127_1892762_2	269797.Mbar_A2040	1.092e-41	162.0	arCOG03379@1|root,arCOG03379@2157|Archaea,2XZH1@28890|Euryarchaeota,2NB1B@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1892762_4	387631.Asulf_00216	6.222e-29	121.0	COG0350@1|root,arCOG02724@2157|Archaea,2XZSR@28890|Euryarchaeota	28890|Euryarchaeota	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,DUF1938
SRR25158203_k127_1892762_1	240015.ACP_0264	5.207e-50	186.0	COG2945@1|root,COG2945@2|Bacteria,3Y35I@57723|Acidobacteria,2JIVZ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
SRR25158203_k127_1892762_5	635013.TherJR_2600	7.174e-17	89.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,2617E@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
SRR25158203_k127_1900494_0	192952.MM_1096	8.538e-169	542.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR25158203_k127_1900494_2	589924.Ferp_0672	6.276e-83	313.0	arCOG09418@1|root,arCOG12382@1|root,arCOG09418@2157|Archaea,arCOG12382@2157|Archaea,2Y2B9@28890|Euryarchaeota,246WU@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1900494_7	246194.CHY_2471	5.895e-19	94.0	COG4273@1|root,COG4273@2|Bacteria,1VPFX@1239|Firmicutes,24UUR@186801|Clostridia,42HFB@68295|Thermoanaerobacterales	186801|Clostridia	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
SRR25158203_k127_1900494_3	1340434.AXVA01000026_gene4101	3.897e-62	222.0	COG0580@1|root,COG0580@2|Bacteria,1TP4T@1239|Firmicutes,4HAWP@91061|Bacilli,1ZCUB@1386|Bacillus	91061|Bacilli	G	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
SRR25158203_k127_1900494_9	1168034.FH5T_05295	4.613e-18	97.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,FrhB_FdhB_C,FrhB_FdhB_N
SRR25158203_k127_1900494_8	342949.PNA2_0801	4.613e-18	97.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,243SX@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
SRR25158203_k127_1900494_10	1209989.TepiRe1_0614	9.738e-18	89.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,42GQB@68295|Thermoanaerobacterales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SRR25158203_k127_1900494_5	118173.KB235914_gene877	9.559e-34	145.0	COG2519@1|root,COG2519@2|Bacteria,1GDNH@1117|Cyanobacteria,1HFFC@1150|Oscillatoriales	1117|Cyanobacteria	J	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1900494_11	604354.TSIB_0587	6.637e-14	79.0	COG3413@1|root,arCOG02271@2157|Archaea,2Y21Q@28890|Euryarchaeota,2443T@183968|Thermococci	183968|Thermococci	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_10
SRR25158203_k127_1900494_4	555079.Toce_0185	2.329e-57	211.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia	186801|Clostridia	P	Arsenite-activated ATPase (ArsA)	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
SRR25158203_k127_1900494_1	386456.JQKN01000019_gene1293	1.418e-101	349.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota	28890|Euryarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR25158203_k127_1900494_6	269797.Mbar_A3443	9.111e-21	102.0	arCOG03477@1|root,arCOG03477@2157|Archaea,2Y33T@28890|Euryarchaeota,2NANU@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1931085_2	269797.Mbar_A3453	2.882e-142	466.0	COG0079@1|root,COG2158@1|root,arCOG04273@2157|Archaea,arCOG05056@2157|Archaea,2XV1E@28890|Euryarchaeota,2N9D3@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,zf-like
SRR25158203_k127_1931085_3	304371.MCP_1953	2.918e-71	252.0	COG1270@1|root,arCOG04274@2157|Archaea,2XT37@28890|Euryarchaeota,2N9JD@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
SRR25158203_k127_1931085_6	1094980.Mpsy_3102	1.163e-63	224.0	COG1267@1|root,arCOG01869@2157|Archaea,2XZTX@28890|Euryarchaeota,2NA1N@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Phosphatidylglycerophosphatase A	-	-	-	-	-	-	-	-	-	-	-	-	PgpA
SRR25158203_k127_1931085_5	269797.Mbar_A3456	1.482e-67	238.0	COG0368@1|root,arCOG04338@2157|Archaea,2XU3T@28890|Euryarchaeota,2N9QS@224756|Methanomicrobia	224756|Methanomicrobia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
SRR25158203_k127_1931085_7	192952.MM_2056	2.733e-55	201.0	COG2266@1|root,arCOG01871@2157|Archaea,2XZP4@28890|Euryarchaeota,2N9T9@224756|Methanomicrobia	224756|Methanomicrobia	M	MobA-like NTP transferase domain	cobY	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SRR25158203_k127_1931085_14	192952.MM_2237	2.819e-18	88.0	COG0640@1|root,arCOG01681@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SRR25158203_k127_1931085_0	1041930.Mtc_0963	1.226e-172	548.0	COG0798@1|root,arCOG02190@2157|Archaea,2XTQC@28890|Euryarchaeota,2N935@224756|Methanomicrobia	224756|Methanomicrobia	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
SRR25158203_k127_1931085_11	269797.Mbar_A1720	1.81e-26	111.0	COG0599@1|root,arCOG02154@2157|Archaea,2Y8IJ@28890|Euryarchaeota,2NB4T@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_1931085_4	1268622.AVS7_03081	4.542e-69	249.0	COG3829@1|root,COG3920@1|root,COG5002@1|root,COG3829@2|Bacteria,COG3920@2|Bacteria,COG5002@2|Bacteria,1MVPJ@1224|Proteobacteria,2VN2J@28216|Betaproteobacteria,4AEHS@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,HisKA_2,PAS,PAS_4,PAS_9
SRR25158203_k127_1931085_15	679926.Mpet_2051	1.178e-17	86.0	COG4828@1|root,arCOG03300@2157|Archaea,2Y0K6@28890|Euryarchaeota,2NA5G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
SRR25158203_k127_1931085_8	1094980.Mpsy_0275	1.118e-37	147.0	COG3794@1|root,arCOG02924@1|root,arCOG02924@2157|Archaea,arCOG02929@2157|Archaea,2Y1NH@28890|Euryarchaeota,2NB8Y@224756|Methanomicrobia	224756|Methanomicrobia	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRR25158203_k127_1931085_12	572478.Vdis_1365	1.206e-24	106.0	COG0640@1|root,arCOG01681@2157|Archaea,2XRJK@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein, ArsR	merR	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SRR25158203_k127_1931085_1	304371.MCP_1059	8.442e-171	559.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-2	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
SRR25158203_k127_1931085_16	634498.mru_1094	2.468e-08	57.0	arCOG04838@1|root,arCOG04838@2157|Archaea,2Y1E7@28890|Euryarchaeota,23PTY@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1931085_9	387093.SUN_0691	3.666e-36	143.0	COG2608@1|root,COG2608@2|Bacteria,1QZND@1224|Proteobacteria,43CM7@68525|delta/epsilon subdivisions,2YQX3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	mercury ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1931085_10	351160.RCIX1586	1.288e-29	123.0	COG0655@1|root,arCOG00510@2157|Archaea	2157|Archaea	C	NAD(P)H dehydrogenase (quinone) activity	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
SRR25158203_k127_1931085_13	869210.Marky_0299	3.129e-20	92.0	COG3370@1|root,COG3370@2|Bacteria,1WKRN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM DsrE DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
SRR25158203_k127_1934795_5	163908.KB235896_gene2024	3.317e-56	198.0	COG0286@1|root,COG0286@2|Bacteria,1G132@1117|Cyanobacteria,1HIFC@1161|Nostocales	1117|Cyanobacteria	V	HsdM N-terminal domain	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
SRR25158203_k127_1934795_0	163908.KB235896_gene2025	0.0	1178.0	COG4096@1|root,COG4096@2|Bacteria,1G3A8@1117|Cyanobacteria,1HJQC@1161|Nostocales	1117|Cyanobacteria	L	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	CarboxypepD_reg,EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
SRR25158203_k127_1934795_14	1045854.WKK_03280	0.0001018	53.0	arCOG05209@1|root,31PIN@2|Bacteria,1V5G2@1239|Firmicutes,4HIRV@91061|Bacilli,4AXU0@81850|Leuconostocaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1934795_10	195522.BD01_2131	1.341e-08	63.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y6E7@28890|Euryarchaeota,244CY@183968|Thermococci	183968|Thermococci	V	Domain of unknown function (DUF3368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
SRR25158203_k127_1934795_8	1056495.Calag_1198	7.934e-13	72.0	COG2405@1|root,COG3609@1|root,arCOG00719@2157|Archaea,arCOG01009@2157|Archaea,2XRHA@28889|Crenarchaeota	28889|Crenarchaeota	K	nucleic acid-binding protein contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1934795_11	1449050.JNLE01000005_gene4444	1.415e-08	57.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the sulfur carrier protein TusA family	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
SRR25158203_k127_1934795_13	573063.Metin_1213	1.518e-06	56.0	COG1553@1|root,arCOG02068@2157|Archaea,2XYJ8@28890|Euryarchaeota,23R0A@183939|Methanococci	183939|Methanococci	P	PFAM DsrE family protein	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
SRR25158203_k127_1934795_9	155515.JP36_00140	2.736e-09	63.0	COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,1S809@1236|Gammaproteobacteria,1Y8TM@135625|Pasteurellales	135625|Pasteurellales	P	DsrE/DsrF-like family	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
SRR25158203_k127_1934795_12	1027273.GZ77_17870	1.645e-08	60.0	COG1553@1|root,COG1553@2|Bacteria,1NDPA@1224|Proteobacteria,1SFY2@1236|Gammaproteobacteria,1XQIZ@135619|Oceanospirillales	135619|Oceanospirillales	P	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
SRR25158203_k127_1934795_7	192952.MM_2352	1.199e-26	111.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y49G@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1934795_2	765420.OSCT_2615	2.264e-221	715.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi,37711@32061|Chloroflexia	32061|Chloroflexia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SRR25158203_k127_1934795_6	1294265.JCM21738_2131	8.033e-47	181.0	COG0530@1|root,COG0530@2|Bacteria,1TRX0@1239|Firmicutes,4HCXU@91061|Bacilli,1ZQT3@1386|Bacillus	91061|Bacilli	P	Sodium/calcium exchanger protein	yrbG	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
SRR25158203_k127_1934795_4	1121918.ARWE01000001_gene457	1.041e-78	276.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,42M92@68525|delta/epsilon subdivisions,2WJ7J@28221|Deltaproteobacteria,43S9I@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
SRR25158203_k127_1934795_1	1232410.KI421417_gene2729	1.695e-227	710.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,43UJH@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Lysine-2,3-aminomutase	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
SRR25158203_k127_1934795_3	1220534.B655_1438	9.789e-82	283.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,23NMV@183925|Methanobacteria	183925|Methanobacteria	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
SRR25158203_k127_1973215_5	192952.MM_2273	1.884e-73	251.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU9Q@28890|Euryarchaeota,2N99Y@224756|Methanomicrobia	224756|Methanomicrobia	K	Belongs to the RNA polymerase beta chain family	rpoB1	-	2.7.7.6	ko:K03045	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3
SRR25158203_k127_1973215_10	387631.Asulf_00705	1.41e-16	83.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
SRR25158203_k127_1973215_4	192952.MM_1278	6.724e-86	290.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,2N9G7@224756|Methanomicrobia	224756|Methanomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
SRR25158203_k127_1973215_2	1094980.Mpsy_1487	1.711e-119	389.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MI@28890|Euryarchaeota,2NBNK@224756|Methanomicrobia	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SRR25158203_k127_1973215_3	1094980.Mpsy_1413	1.804e-108	356.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,2N9E4@224756|Methanomicrobia	224756|Methanomicrobia	F	Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
SRR25158203_k127_1973215_1	1094980.Mpsy_1412	4.983e-135	434.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,2NAMY@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SRR25158203_k127_1973215_9	1094980.Mpsy_1626	4.241e-40	154.0	arCOG04993@1|root,arCOG04993@2157|Archaea,2Y0MZ@28890|Euryarchaeota,2NA0K@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_1973215_6	269797.Mbar_A3132	6.049e-62	219.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota,2N9QD@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM sugar isomerase (SIS)	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
SRR25158203_k127_1973215_0	1094980.Mpsy_1624	4.831e-156	500.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9E9@224756|Methanomicrobia	224756|Methanomicrobia	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SRR25158203_k127_1973215_7	1047013.AQSP01000109_gene2426	1.114e-49	181.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	yukA	-	-	ko:K03466,ko:K12217	-	-	-	-	ko00000,ko02044,ko03036	3.A.12,3.A.7.10.1,3.A.7.9.1	-	-	DUF87,FHA,FtsK_SpoIIIE,FtsK_SpoIIIE_N,TraG-D_C,TrwB_AAD_bind
SRR25158203_k127_2001741_3	868131.MSWAN_1059	8.382e-54	207.0	COG0784@1|root,arCOG06712@1|root,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea,2XWYJ@28890|Euryarchaeota	28890|Euryarchaeota	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4,PAS_9,PadR,Response_reg
SRR25158203_k127_2001741_1	386456.JQKN01000004_gene147	1.054e-83	284.0	COG0467@1|root,arCOG01171@2157|Archaea,2XXJX@28890|Euryarchaeota	28890|Euryarchaeota	T	KaiC	-	-	-	ko:K07331	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ATPase
SRR25158203_k127_2001741_0	386456.JQKN01000002_gene2414	4.081e-92	320.0	arCOG07605@1|root,arCOG07605@2157|Archaea,2XX6C@28890|Euryarchaeota	28890|Euryarchaeota	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
SRR25158203_k127_2001741_2	580332.Slit_1329	3.018e-59	209.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,2WGQ0@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg
SRR25158203_k127_2001741_4	572477.Alvin_2605	1.524e-18	87.0	COG0745@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1RGZF@1224|Proteobacteria,1S6GG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2202 FOG PAS PAC domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9
SRR25158203_k127_2053355_8	1121422.AUMW01000060_gene85	0.0009052	47.0	COG1475@1|root,COG1475@2|Bacteria,1UF7N@1239|Firmicutes,24URT@186801|Clostridia	186801|Clostridia	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,ParBc
SRR25158203_k127_2053355_3	269797.Mbar_A3720	3.991e-126	415.0	COG3875@1|root,arCOG02046@2157|Archaea,2XVDD@28890|Euryarchaeota,2N9Q8@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SRR25158203_k127_2053355_0	504728.K649_06170	4.365e-258	810.0	COG0365@1|root,COG0365@2|Bacteria,1WI8W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SRR25158203_k127_2053355_7	386456.JQKN01000008_gene1451	0.0002093	49.0	COG0589@1|root,arCOG02053@2157|Archaea,2Y8DF@28890|Euryarchaeota,23PV4@183925|Methanobacteria	183925|Methanobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SRR25158203_k127_2053355_4	1459636.NTE_02455	7.756e-68	234.0	COG1143@1|root,COG3260@1|root,arCOG01543@2157|Archaea,arCOG01553@2157|Archaea	2157|Archaea	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
SRR25158203_k127_2053355_5	264732.Moth_2185	8.014e-27	113.0	COG1143@1|root,COG1143@2|Bacteria,1UCGF@1239|Firmicutes,24HKT@186801|Clostridia,42GPS@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K12143	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_7
SRR25158203_k127_2053355_1	247490.KSU1_C0045	1.348e-176	569.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,2IZ46@203682|Planctomycetes	203682|Planctomycetes	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
SRR25158203_k127_2053355_2	351160.RCIX2384	2.151e-164	530.0	COG0651@1|root,arCOG01537@2157|Archaea,2XWXC@28890|Euryarchaeota,2NADW@224756|Methanomicrobia	224756|Methanomicrobia	C	plastoquinone (Complex I)	-	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
SRR25158203_k127_2053355_6	351160.RCIX2385	1.063e-13	71.0	COG4237@1|root,arCOG03626@2157|Archaea	2157|Archaea	C	Hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
SRR25158203_k127_2070814_8	880072.Desac_0517	1.288e-07	54.0	COG0784@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MQVW@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg,dCache_1
SRR25158203_k127_2070814_7	304371.MCP_1047	2.064e-11	70.0	arCOG11708@1|root,arCOG11708@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2070814_3	368407.Memar_2034	3.292e-156	507.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2070814_0	891968.Anamo_1586	2.525e-294	919.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,3TA4P@508458|Synergistetes	508458|Synergistetes	G	PFAM glycosyl transferase family 20	-	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
SRR25158203_k127_2070814_9	1123296.JQKE01000011_gene257	1.27e-05	51.0	COG2026@1|root,COG2026@2|Bacteria,1QDRK@1224|Proteobacteria,2VYUW@28216|Betaproteobacteria	28216|Betaproteobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
SRR25158203_k127_2070814_6	269797.Mbar_A1020	6.415e-16	79.0	arCOG03966@1|root,arCOG03966@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2070814_5	246194.CHY_0708	9.064e-95	316.0	COG0070@1|root,COG0070@2|Bacteria,1TQEB@1239|Firmicutes,24AQ1@186801|Clostridia,42EKT@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM glutamate synthase alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
SRR25158203_k127_2070814_1	304371.MCP_0709	1.167e-233	732.0	COG0069@1|root,COG1145@1|root,arCOG00619@2157|Archaea,arCOG02460@2157|Archaea,2Y7H6@28890|Euryarchaeota,2N95Y@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the glutamate synthase family	gltB2	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0664	Fer4,Fer4_10,Fer4_9,Glu_syn_central,Glu_synthase
SRR25158203_k127_2070814_2	1041930.Mtc_1482	6.434e-162	517.0	COG0067@1|root,arCOG00095@2157|Archaea,2XUF6@28890|Euryarchaeota,2N91X@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM glutamine amidotransferase, class-II	gltB1	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0665	GATase_2,GATase_6
SRR25158203_k127_2070814_4	246194.CHY_0714	1.324e-119	398.0	COG1150@1|root,COG2048@1|root,COG1150@2|Bacteria,COG2048@2|Bacteria,1V67B@1239|Firmicutes,248DI@186801|Clostridia,42H12@68295|Thermoanaerobacterales	186801|Clostridia	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SRR25158203_k127_2077499_2	1041930.Mtc_2273	4.045e-26	108.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZZ4@28890|Euryarchaeota,2N9YN@224756|Methanomicrobia	224756|Methanomicrobia	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SRR25158203_k127_2077499_0	1094980.Mpsy_2839	1.732e-259	814.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,2N9CP@224756|Methanomicrobia	224756|Methanomicrobia	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
SRR25158203_k127_2077499_1	1094980.Mpsy_2840	2.024e-66	232.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,2N9CW@224756|Methanomicrobia	224756|Methanomicrobia	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
SRR25158203_k127_2085187_24	1041930.Mtc_0862	5.866e-10	63.0	COG2892@1|root,arCOG04414@2157|Archaea,2Y1HA@28890|Euryarchaeota,2NA4K@224756|Methanomicrobia	224756|Methanomicrobia	S	Transcription factor Pcc1	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
SRR25158203_k127_2085187_7	1449126.JQKL01000073_gene3045	8.806e-80	278.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,268U9@186813|unclassified Clostridiales	186801|Clostridia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
SRR25158203_k127_2085187_1	1041930.Mtc_0022	9.294e-214	682.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,2N97T@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
SRR25158203_k127_2085187_6	192952.MM_0111	8.719e-83	284.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT8Z@28890|Euryarchaeota,2NA1D@224756|Methanomicrobia	224756|Methanomicrobia	H	RimK domain protein ATP-grasp	-	-	6.3.2.33	ko:K05844,ko:K15740	ko00790,map00790	-	R09594	RC00064,RC00141	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK
SRR25158203_k127_2085187_10	1094980.Mpsy_2610	1.191e-42	164.0	COG2454@1|root,arCOG03229@2157|Archaea,2XZNK@28890|Euryarchaeota,2NAY7@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
SRR25158203_k127_2085187_5	1094980.Mpsy_1228	9.722e-138	445.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,2N91R@224756|Methanomicrobia	224756|Methanomicrobia	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	-	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
SRR25158203_k127_2085187_20	1094980.Mpsy_0929	1.639e-11	72.0	arCOG05012@1|root,arCOG05012@2157|Archaea,2Y5SG@28890|Euryarchaeota,2NBD0@224756|Methanomicrobia	224756|Methanomicrobia	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
SRR25158203_k127_2085187_14	1094980.Mpsy_1199	1.942e-28	115.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,2NB8N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2085187_16	1094980.Mpsy_2445	1.619e-20	99.0	arCOG04038@1|root,arCOG04038@2157|Archaea,2Y5TS@28890|Euryarchaeota,2NBDA@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2085187_18	1041930.Mtc_1186	1.48e-13	73.0	arCOG02140@1|root,arCOG02140@2157|Archaea,2Y5Y2@28890|Euryarchaeota,2NBBF@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2085187_0	269797.Mbar_A0571	2.548e-221	697.0	COG0138@1|root,arCOG02824@2157|Archaea,2XT5P@28890|Euryarchaeota,2N92Z@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0571	AICARFT_IMPCHas,MGS
SRR25158203_k127_2085187_15	1041930.Mtc_1868	3.684e-28	115.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,2NB7P@224756|Methanomicrobia	224756|Methanomicrobia	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
SRR25158203_k127_2085187_13	589924.Ferp_1540	2.055e-29	119.0	COG4274@1|root,arCOG01119@2157|Archaea,2Y204@28890|Euryarchaeota,2477I@183980|Archaeoglobi	183980|Archaeoglobi	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
SRR25158203_k127_2085187_11	1306990.BARG01000030_gene3382	4.399e-41	159.0	COG1139@1|root,COG1139@2|Bacteria,2I7CT@201174|Actinobacteria	201174|Actinobacteria	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
SRR25158203_k127_2085187_12	273116.14324970	1.263e-40	153.0	COG1832@1|root,arCOG04227@2157|Archaea,2XXS6@28890|Euryarchaeota,242BJ@183967|Thermoplasmata	183967|Thermoplasmata	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
SRR25158203_k127_2085187_4	1094980.Mpsy_2495	2.826e-164	522.0	COG0535@1|root,arCOG00940@2157|Archaea,2XTQH@28890|Euryarchaeota	28890|Euryarchaeota	S	Radical SAM	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
SRR25158203_k127_2085187_9	1094980.Mpsy_2494	8.72e-54	193.0	COG1522@1|root,arCOG01629@2157|Archaea,2Y851@28890|Euryarchaeota,2N9XY@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein AsnC Lrp family	-	-	-	ko:K22225	-	-	-	-	ko00000	-	-	-	HTH_AsnC-type
SRR25158203_k127_2085187_21	123214.PERMA_0842	4.998e-11	64.0	2C5TN@1|root,30GQP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2085187_2	1094980.Mpsy_0967	1.809e-195	614.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9HE@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
SRR25158203_k127_2085187_3	710686.Mycsm_03805	1.933e-183	588.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,OapA,OapA_N,PA14,Peptidase_M23
SRR25158203_k127_2085187_8	710686.Mycsm_03804	2.932e-72	247.0	29W9K@1|root,30HUY@2|Bacteria,2H1KD@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2085187_19	591159.ACEZ01000002_gene6055	1.504e-12	68.0	COG3293@1|root,COG3293@2|Bacteria,2GMT0@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
SRR25158203_k127_2085187_17	1469607.KK073768_gene306	1.533e-15	76.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
SRR25158203_k127_2085187_25	929556.Solca_2679	4.248e-09	68.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	ko:K14054	-	-	-	-	ko00000	-	-	-	Peptidase_M14
SRR25158203_k127_2085187_23	1038860.AXAP01000055_gene3528	5.642e-10	73.0	COG1705@1|root,COG1876@1|root,COG3409@1|root,COG1705@2|Bacteria,COG1876@2|Bacteria,COG3409@2|Bacteria,1Q6GA@1224|Proteobacteria,2VCM5@28211|Alphaproteobacteria,3K56M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	MNU	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2085187_26	357808.RoseRS_1654	6.805e-09	69.0	COG3409@1|root,COG3409@2|Bacteria,2G92Y@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,PG_binding_1
SRR25158203_k127_2087956_2	489825.LYNGBM3L_54460	6.343e-55	206.0	COG3221@1|root,COG3221@2|Bacteria,1G2AZ@1117|Cyanobacteria,1HAC9@1150|Oscillatoriales	1117|Cyanobacteria	P	COG3221 ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
SRR25158203_k127_2087956_0	247490.KSU1_C0881	1.904e-173	562.0	COG1387@1|root,COG1387@2|Bacteria,2IWW1@203682|Planctomycetes	203682|Planctomycetes	L	DNA polymerase	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
SRR25158203_k127_2087956_1	1047013.AQSP01000037_gene1327	1.963e-81	278.0	COG1063@1|root,COG1063@2|Bacteria,2NPK3@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SRR25158203_k127_2103655_20	313606.M23134_00658	2.369e-38	147.0	COG3243@1|root,COG3243@2|Bacteria,4P0GQ@976|Bacteroidetes,47TSY@768503|Cytophagia	976|Bacteroidetes	I	PHB de-polymerase C-terminus	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
SRR25158203_k127_2103655_19	1123065.ATWL01000013_gene1154	4.574e-41	167.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
SRR25158203_k127_2103655_9	868595.Desca_0946	7.591e-80	273.0	COG0020@1|root,COG0020@2|Bacteria,1TRKB@1239|Firmicutes,248R2@186801|Clostridia,2612A@186807|Peptococcaceae	186801|Clostridia	I	PFAM Di-trans-poly-cis-decaprenylcistransferase	uppS1	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SRR25158203_k127_2103655_17	1094980.Mpsy_0994	1.973e-46	179.0	COG1503@1|root,arCOG01743@2157|Archaea,2XUJ5@28890|Euryarchaeota,2N9TU@224756|Methanomicrobia	224756|Methanomicrobia	J	eRF1 domain 2	-	-	-	-	-	-	-	-	-	-	-	-	eRF1_2
SRR25158203_k127_2103655_24	224325.AF_1106	8.523e-16	82.0	COG2136@1|root,arCOG03247@2157|Archaea,2XZNB@28890|Euryarchaeota,2476P@183980|Archaeoglobi	183980|Archaeoglobi	J	Probably involved in the biogenesis of the ribosome	-	-	-	ko:K14561	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	-
SRR25158203_k127_2103655_23	1094980.Mpsy_2732	1.061e-19	90.0	COG1996@1|root,arCOG04341@2157|Archaea,2XZUD@28890|Euryarchaeota,2NA5N@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
SRR25158203_k127_2103655_21	269797.Mbar_A2508	6.847e-26	111.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,2N9ZP@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
SRR25158203_k127_2103655_1	351160.RCIX2125	8.313e-114	372.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2N93P@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
SRR25158203_k127_2103655_2	351160.RCIX2124	5.726e-112	366.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,2N95P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
SRR25158203_k127_2103655_8	192952.MM_2622	6.898e-80	276.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,2N9KQ@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6,S1
SRR25158203_k127_2103655_3	1041930.Mtc_0868	6.742e-97	321.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,2N9D8@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Shwachman-Bodian-Diamond syndrome	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
SRR25158203_k127_2103655_0	269797.Mbar_A2503	1.586e-121	394.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
SRR25158203_k127_2103655_22	192952.MM_2619	2.399e-24	106.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2NA1F@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
SRR25158203_k127_2103655_18	1094980.Mpsy_2724	4.384e-44	169.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,2N9T6@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
SRR25158203_k127_2103655_10	204669.Acid345_1870	1.029e-79	282.0	COG0672@1|root,COG0672@2|Bacteria,3Y3XB@57723|Acidobacteria,2JI3D@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM Iron permease FTR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318,FTR1
SRR25158203_k127_2103655_13	698757.Pogu_2215	2.434e-56	209.0	COG3221@1|root,arCOG01805@2157|Archaea	2157|Archaea	P	ABC-type phosphate phosphonate transport system, periplasmic component	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
SRR25158203_k127_2103655_15	436308.Nmar_0874	3.058e-52	192.0	COG3638@1|root,arCOG00206@2157|Archaea,41SY4@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ABC transporter	-	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
SRR25158203_k127_2103655_12	436308.Nmar_0873	1.474e-58	212.0	COG3639@1|root,arCOG00173@2157|Archaea,41SZI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	phosphonate ABC transporter, inner membrane subunit	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
SRR25158203_k127_2103655_5	204669.Acid345_1869	2.05e-89	310.0	COG0577@1|root,COG0577@2|Bacteria,3Y36A@57723|Acidobacteria,2JIYT@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SRR25158203_k127_2103655_14	1354300.AUQY01000002_gene1226	8.916e-56	208.0	COG0577@1|root,COG0577@2|Bacteria,1TUYK@1239|Firmicutes,24CIB@186801|Clostridia,22JFI@1570339|Peptoniphilaceae	186801|Clostridia	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SRR25158203_k127_2103655_7	1034769.KB910518_gene321	2.593e-83	282.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HVXG@91061|Bacilli,2721W@186822|Paenibacillaceae	91061|Bacilli	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR25158203_k127_2103655_16	479434.Sthe_1384	6.409e-49	183.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,2G6N4@200795|Chloroflexi,27YBV@189775|Thermomicrobia	189775|Thermomicrobia	K	FeoA	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
SRR25158203_k127_2103655_6	192952.MM_1548	1.055e-86	295.0	COG1082@1|root,arCOG01895@2157|Archaea,2Y6X2@28890|Euryarchaeota,2NAFW@224756|Methanomicrobia	224756|Methanomicrobia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SRR25158203_k127_2103655_4	374847.Kcr_0286	1.718e-93	315.0	COG2248@1|root,arCOG00969@2157|Archaea	2157|Archaea	S	Belongs to the UPF0282 family	-	-	-	ko:K07022	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
SRR25158203_k127_2103655_11	1094980.Mpsy_2013	9.61e-77	262.0	COG1233@1|root,arCOG01524@2157|Archaea,2XSYN@28890|Euryarchaeota,2NA9X@224756|Methanomicrobia	224756|Methanomicrobia	Q	GDP dissociation inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
SRR25158203_k127_2107164_6	1094980.Mpsy_2247	1.377e-24	103.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR25158203_k127_2107164_2	269797.Mbar_A1370	6.844e-100	336.0	COG4012@1|root,arCOG04365@2157|Archaea,2XUWU@28890|Euryarchaeota,2N9HK@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative pyruvate format-lyase activating enzyme (DUF1786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
SRR25158203_k127_2107164_3	192952.MM_1478	3.347e-56	201.0	COG0521@1|root,arCOG00214@2157|Archaea,2XWJF@28890|Euryarchaeota,2N9SU@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM molybdenum cofactor synthesis domain	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
SRR25158203_k127_2107164_1	1121423.JONT01000032_gene2582	2.112e-129	427.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,249RZ@186801|Clostridia,2610Z@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SRR25158203_k127_2107164_4	304371.MCP_1449	1.21e-39	152.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,2N9WI@224756|Methanomicrobia	224756|Methanomicrobia	L	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
SRR25158203_k127_2107164_5	32057.KB217478_gene2807	2.829e-33	135.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1HJAX@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_2107164_0	304371.MCP_2273	9.601e-139	451.0	arCOG00787@1|root,arCOG00787@2157|Archaea	2157|Archaea	L	UvrD REP helicase	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
SRR25158203_k127_2157311_2	632335.Calkr_0387	3.095e-72	250.0	COG0675@1|root,COG0675@2|Bacteria,1TQAH@1239|Firmicutes,249JS@186801|Clostridia	186801|Clostridia	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
SRR25158203_k127_2157311_3	1094980.Mpsy_2548	9.701e-18	88.0	arCOG04960@1|root,arCOG04960@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2157311_1	192952.MM_2989	5.667e-120	395.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,2N9U1@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S protein PflX, homolog of pyruvate formate lyase activating	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SRR25158203_k127_2157311_0	1094980.Mpsy_0796	1.903e-193	615.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,2N91G@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
SRR25158203_k127_2200119_0	192952.MM_3076	4.307e-286	891.0	COG0550@1|root,arCOG01527@2157|Archaea,arCOG06233@2157|Archaea,2XU6T@28890|Euryarchaeota,2N96B@224756|Methanomicrobia	224756|Methanomicrobia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Topoisom_bac,Toprim,zf-C4_Topoisom
SRR25158203_k127_2200119_2	589924.Ferp_1121	2.434e-13	72.0	COG0425@1|root,arCOG02062@2157|Archaea,2Y7FA@28890|Euryarchaeota,247DS@183980|Archaeoglobi	183980|Archaeoglobi	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
SRR25158203_k127_2200119_1	555079.Toce_2158	8.485e-33	134.0	2E2B7@1|root,32XGJ@2|Bacteria,1UPQ4@1239|Firmicutes,25HKV@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2204706_5	706587.Desti_2017	1.707e-51	188.0	COG1196@1|root,COG1352@1|root,COG2201@1|root,COG1196@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,1NQTI@1224|Proteobacteria,43C0D@68525|delta/epsilon subdivisions,2WIYN@28221|Deltaproteobacteria,2MRCJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS_10,PAS_4
SRR25158203_k127_2204706_4	1459636.NTE_00463	1.022e-54	204.0	COG3177@1|root,arCOG03112@2157|Archaea	2157|Archaea	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
SRR25158203_k127_2204706_10	572546.Arcpr_0963	3.467e-16	78.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
SRR25158203_k127_2204706_6	673860.AciM339_0295	2.677e-51	192.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,3F2N5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	UbiA prenyltransferase family	ubiA	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
SRR25158203_k127_2204706_7	402880.MmarC5_1385	1.628e-39	159.0	COG3503@1|root,arCOG04370@2157|Archaea,2XWYK@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
SRR25158203_k127_2204706_3	316067.Geob_0747	6.119e-59	215.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
SRR25158203_k127_2204706_0	1094980.Mpsy_1028	4.104e-211	662.0	COG0119@1|root,arCOG02093@2157|Archaea,2XVVR@28890|Euryarchaeota,2N9C3@224756|Methanomicrobia	224756|Methanomicrobia	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
SRR25158203_k127_2204706_2	269797.Mbar_A0999	2.642e-144	465.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2N989@224756|Methanomicrobia	224756|Methanomicrobia	C	thiamine pyrophosphate enzyme domain protein TPP-binding	porB-1	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SRR25158203_k127_2204706_1	1094980.Mpsy_1765	2.122e-180	572.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,2N98Z@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA-1	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
SRR25158203_k127_2204706_8	593750.Metfor_2539	5.38e-32	126.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota,2N9YE@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	porD-1	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
SRR25158203_k127_2204706_9	1094980.Mpsy_1767	2.906e-25	106.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,2N9J1@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC-1	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SRR25158203_k127_2211949_2	304371.MCP_1759	4.498e-59	219.0	COG3372@1|root,arCOG04356@2157|Archaea,2XSTX@28890|Euryarchaeota,2N95G@224756|Methanomicrobia	224756|Methanomicrobia	L	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
SRR25158203_k127_2211949_0	269797.Mbar_A2643	1.009e-141	465.0	COG1061@1|root,arCOG00874@2157|Archaea,2XTYQ@28890|Euryarchaeota,2N95D@224756|Methanomicrobia	224756|Methanomicrobia	L	helicase superfamily c-terminal domain	rad25	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,ResIII
SRR25158203_k127_2211949_1	1122138.AQUZ01000001_gene1522	5.406e-105	351.0	28ISE@1|root,2Z8RK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2211949_3	521011.Mpal_0989	9.335e-21	94.0	arCOG09454@1|root,arCOG09454@2157|Archaea,2Y4CS@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2217241_2	635013.TherJR_0123	4.387e-33	133.0	COG0840@1|root,COG5278@1|root,COG0840@2|Bacteria,COG5278@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,261EY@186807|Peptococcaceae	186801|Clostridia	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1
SRR25158203_k127_2217241_1	521011.Mpal_2434	6.118e-64	228.0	COG4742@1|root,arCOG04362@2157|Archaea,2XYCM@28890|Euryarchaeota,2N9SJ@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function (DUF1724)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1724
SRR25158203_k127_2217241_0	269797.Mbar_A1225	5.709e-81	280.0	COG0382@1|root,arCOG00481@2157|Archaea,2XYIF@28890|Euryarchaeota,2N9PK@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UbiA prenyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
SRR25158203_k127_2217241_4	579137.Metvu_0819	2.613e-28	121.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XWXW@28890|Euryarchaeota,23QUZ@183939|Methanococci	183939|Methanococci	S	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-ribbon_3,zinc_ribbon_2
SRR25158203_k127_2217241_3	269797.Mbar_A0868	9.634e-29	128.0	arCOG03489@1|root,arCOG03489@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2217241_9	192952.MM_1410	9.649e-10	68.0	arCOG03489@1|root,arCOG03489@2157|Archaea	192952.MM_1410|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2217241_8	870967.VIS19158_05884	1.187e-12	76.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XTGI@135623|Vibrionales	135623|Vibrionales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	luxO	GO:0000156,GO:0000160,GO:0003674,GO:0003700,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	ko:K10912	ko02020,ko02024,ko05111,map02020,map02024,map05111	M00513	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SRR25158203_k127_2217241_7	1094980.Mpsy_0480	2.265e-25	113.0	COG1681@1|root,arCOG01829@2157|Archaea,2XTEE@28890|Euryarchaeota	28890|Euryarchaeota	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB1	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SRR25158203_k127_2217241_6	1094980.Mpsy_0480	1.354e-27	120.0	COG1681@1|root,arCOG01829@2157|Archaea,2XTEE@28890|Euryarchaeota	28890|Euryarchaeota	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB1	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SRR25158203_k127_2217241_5	1094980.Mpsy_0484	3.684e-28	120.0	COG1681@1|root,arCOG01829@2157|Archaea,2XTEE@28890|Euryarchaeota	28890|Euryarchaeota	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB1	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SRR25158203_k127_2224523_4	1094980.Mpsy_2743	2.466e-31	125.0	COG2003@1|root,arCOG04919@2157|Archaea,2XY1U@28890|Euryarchaeota,2N9SM@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
SRR25158203_k127_2224523_3	192952.MM_2793	6.373e-46	175.0	COG0746@1|root,arCOG01872@2157|Archaea,2XWJR@28890|Euryarchaeota,2N9W7@224756|Methanomicrobia	224756|Methanomicrobia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
SRR25158203_k127_2224523_2	1041930.Mtc_0273	2.286e-70	246.0	COG1526@1|root,arCOG04358@2157|Archaea,2XY9R@28890|Euryarchaeota,2NB0N@224756|Methanomicrobia	224756|Methanomicrobia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
SRR25158203_k127_2224523_5	1121459.AQXE01000017_gene2148	4.257e-31	127.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,2MB9Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Molybdopterin guanine dinucleotide synthesis protein B	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
SRR25158203_k127_2224523_8	52598.EE36_08658	2.656e-08	59.0	COG1522@1|root,COG1522@2|Bacteria,1RI7R@1224|Proteobacteria,2U9CC@28211|Alphaproteobacteria,3ZX7P@60136|Sulfitobacter	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	aldR	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
SRR25158203_k127_2224523_0	521011.Mpal_1246	7.096e-197	627.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XVRP@28890|Euryarchaeota,2N9CF@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRR25158203_k127_2224523_7	1094980.Mpsy_2002	5.89e-22	96.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
SRR25158203_k127_2224523_1	1408422.JHYF01000008_gene3784	1.695e-174	554.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,36E70@31979|Clostridiaceae	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
SRR25158203_k127_2224523_6	416591.Tlet_1800	6.219e-27	122.0	COG1597@1|root,COG1597@2|Bacteria,2GEA5@200918|Thermotogae	200918|Thermotogae	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2224894_4	272123.Anacy_3008	9.646e-20	90.0	COG3385@1|root,COG3385@2|Bacteria,1G2T1@1117|Cyanobacteria,1HMX0@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_5,DDE_Tnp_1
SRR25158203_k127_2224894_3	886293.Sinac_2126	6.279e-43	169.0	COG3464@1|root,COG3464@2|Bacteria,2J105@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
SRR25158203_k127_2224894_8	449447.MAE_34180	0.0008324	47.0	COG3464@1|root,COG3464@2|Bacteria,1G377@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
SRR25158203_k127_2224894_0	1041930.Mtc_0260	0.0	1071.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2NAP2@224756|Methanomicrobia	224756|Methanomicrobia	D	Cell division protein 48 (CDC48) domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
SRR25158203_k127_2224894_1	1094980.Mpsy_0498	3.831e-190	603.0	COG0104@1|root,arCOG04387@2157|Archaea,2XT59@28890|Euryarchaeota,2N9T2@224756|Methanomicrobia	224756|Methanomicrobia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SRR25158203_k127_2224894_7	525368.HMPREF0591_3856	3.137e-11	71.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRR25158203_k127_2224894_5	565033.GACE_0113	2.61e-14	74.0	arCOG04481@1|root,arCOG04481@2157|Archaea,2Y0HE@28890|Euryarchaeota,246H8@183980|Archaeoglobi	183980|Archaeoglobi	S	Family of unknown function (DUF5350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5350
SRR25158203_k127_2224894_2	192952.MM_2077	2e-97	323.0	COG1458@1|root,arCOG00720@2157|Archaea,2XUK7@28890|Euryarchaeota,2NAIW@224756|Methanomicrobia	224756|Methanomicrobia	V	PINc domain ribonuclease	-	-	-	ko:K09006	-	-	-	-	ko00000	-	-	-	PIN_5
SRR25158203_k127_2224894_6	1094980.Mpsy_1402	1.145e-11	68.0	arCOG04909@1|root,arCOG04909@2157|Archaea,2Y18R@28890|Euryarchaeota,2NA2P@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2248247_0	192952.MM_1297	1.106e-114	378.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2N9B3@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
SRR25158203_k127_2248247_13	589924.Ferp_1695	1.34e-12	71.0	COG3432@1|root,arCOG01055@2157|Archaea,2Y15R@28890|Euryarchaeota,247GS@183980|Archaeoglobi	183980|Archaeoglobi	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR25158203_k127_2248247_5	351160.LRC26	1.834e-80	274.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,2N9HV@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SRR25158203_k127_2248247_1	269797.Mbar_A0613	3.551e-109	362.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,2N993@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
SRR25158203_k127_2248247_10	351160.LRC24	3.549e-29	119.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,2N9U8@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
SRR25158203_k127_2248247_3	321327.CYA_0391	2.694e-92	317.0	COG0520@1|root,COG0520@2|Bacteria,1G15D@1117|Cyanobacteria,1GZJ6@1129|Synechococcus	1117|Cyanobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
SRR25158203_k127_2248247_2	269797.Mbar_A1422	4.979e-101	335.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,2N9H3@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
SRR25158203_k127_2248247_4	304371.MCP_1641	8.006e-89	297.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,2N9BZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SRR25158203_k127_2248247_12	589924.Ferp_1961	1.554e-17	83.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,247A2@183980|Archaeoglobi	183980|Archaeoglobi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
SRR25158203_k127_2248247_11	269797.Mbar_A1425	2.423e-25	105.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,2NA2D@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
SRR25158203_k127_2248247_8	1094980.Mpsy_0878	4.732e-47	172.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2N9S9@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SRR25158203_k127_2248247_7	1094980.Mpsy_0877	1.343e-47	174.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,2N9Q5@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SRR25158203_k127_2248247_9	269797.Mbar_A1428	2.568e-32	129.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2N9UH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
SRR25158203_k127_2248247_6	69014.TK2109	6.621e-54	201.0	COG1856@1|root,arCOG05825@2157|Archaea,2XY8U@28890|Euryarchaeota,242JU@183968|Thermococci	183968|Thermococci	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
SRR25158203_k127_2248247_14	272844.PAB1581	0.0002323	46.0	arCOG02979@1|root,arCOG02979@2157|Archaea,2XT08@28890|Euryarchaeota,242QH@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2280617_2	1165094.RINTHH_17370	4.014e-11	74.0	COG2006@1|root,COG2006@2|Bacteria,1G1NA@1117|Cyanobacteria,1HIZ6@1161|Nostocales	1117|Cyanobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SRR25158203_k127_2280617_1	945713.IALB_2133	6.67e-34	143.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	ycjS	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SRR25158203_k127_2280617_0	1131269.AQVV01000009_gene1094	1.359e-94	327.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR25158203_k127_2300487_0	304371.MCP_0398	1.435e-315	983.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SRR25158203_k127_2300487_5	351160.RCIX1539	5.52e-23	104.0	COG1476@1|root,arCOG01864@2157|Archaea	2157|Archaea	K	transcriptional	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SRR25158203_k127_2300487_6	579137.Metvu_0096	1.973e-08	63.0	COG3351@1|root,arCOG02964@2157|Archaea,2XVP0@28890|Euryarchaeota,23Q7Z@183939|Methanococci	183939|Methanococci	N	flagella protein	flaD	-	-	ko:K07327	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_fla_DE
SRR25158203_k127_2300487_3	1142394.PSMK_08370	7.127e-82	284.0	COG1077@1|root,COG1077@2|Bacteria	2|Bacteria	D	Cell shape determining protein MreB Mrl	mreB2	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
SRR25158203_k127_2300487_2	1094980.Mpsy_2819	2.105e-162	520.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,2N9EZ@224756|Methanomicrobia	224756|Methanomicrobia	I	Belongs to the HMG-CoA reductase family	hmgA-2	-	1.1.1.34	ko:K00021	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1972	HMG-CoA_red
SRR25158203_k127_2300487_4	192952.MM_0334	2.192e-47	173.0	arCOG02070@1|root,arCOG02070@2157|Archaea	2157|Archaea	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
SRR25158203_k127_2300487_1	1041930.Mtc_0274	4.999e-194	612.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota	28890|Euryarchaeota	I	Belongs to the HMG-CoA reductase family	hmgA-1	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
SRR25158203_k127_2317402_0	880072.Desac_2171	5.579e-64	231.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
SRR25158203_k127_2317402_3	387631.Asulf_00149	3.757e-11	67.0	arCOG10388@1|root,arCOG10388@2157|Archaea,2Y57I@28890|Euryarchaeota,247FR@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2317402_1	1094980.Mpsy_0354	4.57e-63	231.0	COG0642@1|root,COG2202@1|root,arCOG02374@2157|Archaea,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_2317402_2	667014.Thein_1165	3.121e-56	202.0	COG0778@1|root,COG0778@2|Bacteria,2GHTQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRR25158203_k127_2333280_7	247490.KSU1_D0212	1.915e-24	119.0	COG3012@1|root,COG3012@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07039,ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	DUF1186,Peptidase_M90,SEC-C
SRR25158203_k127_2333280_0	269797.Mbar_A0508	2.758e-231	722.0	COG1541@1|root,arCOG02622@2157|Archaea,2XVU6@28890|Euryarchaeota,2N93X@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
SRR25158203_k127_2333280_8	1041146.ATZB01000025_gene5548	9.34e-06	48.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,4B9B5@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
SRR25158203_k127_2333280_5	316067.Geob_0747	1.549e-56	208.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
SRR25158203_k127_2333280_4	192952.MM_0848	1.582e-59	219.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y29P@28890|Euryarchaeota,2NA5X@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2333280_3	521011.Mpal_2086	2.753e-61	217.0	COG3467@1|root,arCOG00520@2157|Archaea,2XXWD@28890|Euryarchaeota,2NAW4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
SRR25158203_k127_2333280_1	1499967.BAYZ01000155_gene659	1.745e-135	461.0	COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,2NR7U@2323|unclassified Bacteria	2|Bacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SRR25158203_k127_2333280_2	386456.JQKN01000007_gene3172	1.267e-78	286.0	COG0642@1|root,COG2202@1|root,arCOG02352@1|root,arCOG06712@1|root,arCOG02352@2157|Archaea,arCOG02358@2157|Archaea,arCOG06712@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF,GAF_2,GAF_3,HATPase_c,HTH_10,HisKA,HisKA_4TM,PAS,PAS_3,PAS_4,PAS_9
SRR25158203_k127_2333280_6	247490.KSU1_D0230	7.719e-44	162.0	COG2199@1|root,COG2203@1|root,COG3452@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3452@2|Bacteria	2|Bacteria	T	CHASE	ytrP	-	2.7.7.65	ko:K02488,ko:K21009	ko02020,ko02025,ko04112,map02020,map02025,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS_3,PAS_8,Response_reg
SRR25158203_k127_2334150_4	269797.Mbar_A1626	8.898e-75	280.0	COG1404@1|root,arCOG02512@1|root,arCOG00702@2157|Archaea,arCOG02512@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
SRR25158203_k127_2334150_7	1094980.Mpsy_2521	1.077e-19	105.0	arCOG02538@1|root,arCOG02542@1|root,arCOG02538@2157|Archaea,arCOG02542@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CARDB,PKD,PQQ_3
SRR25158203_k127_2334150_0	1183377.Py04_0863	6.078e-184	584.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
SRR25158203_k127_2334150_3	221288.JH992901_gene2375	3.952e-79	269.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria,1JI0S@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SRR25158203_k127_2334150_1	1173024.KI912148_gene4324	6.592e-119	407.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1JK1R@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SRR25158203_k127_2334150_2	118173.KB235914_gene1175	7.888e-110	372.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G1Z5@1117|Cyanobacteria,1HH3F@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
SRR25158203_k127_2334150_5	579137.Metvu_1096	5.053e-64	224.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota,23QUS@183939|Methanococci	183939|Methanococci	C	TIGRFAM archaeoflavoprotein AfpA	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
SRR25158203_k127_2334150_6	1094980.Mpsy_2028	3.74e-45	166.0	COG0655@1|root,arCOG02573@2157|Archaea,2XVV1@28890|Euryarchaeota,2N9GH@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SRR25158203_k127_2353345_9	1250006.JHZZ01000001_gene3301	2.437e-17	82.0	COG1502@1|root,COG1502@2|Bacteria,4NN1I@976|Bacteroidetes,1I2F3@117743|Flavobacteriia,3VX8J@52959|Polaribacter	976|Bacteroidetes	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
SRR25158203_k127_2353345_10	1121405.dsmv_2012	9.582e-16	79.0	COG1036@1|root,COG1036@2|Bacteria	2|Bacteria	C	dihydromethanopterin reductase activity	gltD	-	1.2.7.3,1.97.1.9	ko:K00176,ko:K06411,ko:K12527	ko00020,ko00450,ko00720,ko01100,ko01120,ko01200,map00020,map00450,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197,R07229	RC00004,RC02420,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Fer4_7,Flavoprotein,Pyr_redox_2,Pyr_redox_3
SRR25158203_k127_2353345_3	439481.Aboo_1073	5.285e-58	209.0	COG0639@1|root,arCOG01143@2157|Archaea,2XUDG@28890|Euryarchaeota,3F38Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Calcineurin-like phosphoesterase superfamily domain	rad24	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
SRR25158203_k127_2353345_2	891968.Anamo_1109	4.457e-69	246.0	COG2516@1|root,COG2516@2|Bacteria,3TB3Y@508458|Synergistetes	508458|Synergistetes	S	Radical SAM domain protein	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
SRR25158203_k127_2353345_0	1041930.Mtc_0756	1.42e-276	865.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
SRR25158203_k127_2353345_4	868131.MSWAN_0995	6.903e-57	215.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,23PMF@183925|Methanobacteria	183925|Methanobacteria	C	Fe-S cluster	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SRR25158203_k127_2353345_1	386456.JQKN01000001_gene2186	1.484e-138	450.0	COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,23NPK@183925|Methanobacteria	183925|Methanobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SRR25158203_k127_2353345_5	224325.AF_0187	4.465e-45	166.0	COG2044@1|root,arCOG02066@2157|Archaea,2XWA5@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM DsrE family protein	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,TusA
SRR25158203_k127_2353345_6	1094980.Mpsy_1384	5.955e-40	150.0	arCOG04743@1|root,arCOG04743@2157|Archaea,2XXSX@28890|Euryarchaeota,2NA4F@224756|Methanomicrobia	224756|Methanomicrobia	S	Non-histone chromosomal protein MC1	-	-	-	-	-	-	-	-	-	-	-	-	MC1
SRR25158203_k127_2353345_8	351160.RCIX1504	7.031e-25	115.0	COG1266@1|root,arCOG02769@2157|Archaea	2157|Archaea	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi,TPR_12
SRR25158203_k127_2353345_7	1238425.J07HQW2_01231	1.788e-37	152.0	COG0582@1|root,arCOG01241@2157|Archaea	2157|Archaea	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integr_3,Phage_integrase
SRR25158203_k127_2355202_10	1248232.BANQ01000143_gene3646	1.233e-15	81.0	COG1943@1|root,COG1943@2|Bacteria,1RC43@1224|Proteobacteria,1S3FI@1236|Gammaproteobacteria,1XXJF@135623|Vibrionales	135623|Vibrionales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
SRR25158203_k127_2355202_9	269797.Mbar_A0392	6.511e-17	84.0	COG2811@1|root,arCOG03363@2157|Archaea,2Y73N@28890|Euryarchaeota,2NB93@224756|Methanomicrobia	224756|Methanomicrobia	C	H subunit	-	-	-	ko:K02107	ko00190,map00190	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V-ATPase_G_2
SRR25158203_k127_2355202_2	1041930.Mtc_1401	1.385e-149	496.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2N9EB@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-1	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
SRR25158203_k127_2355202_8	589924.Ferp_2308	2.595e-21	95.0	COG0636@1|root,arCOG02455@2157|Archaea,2XZRP@28890|Euryarchaeota,246DQ@183980|Archaeoglobi	183980|Archaeoglobi	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
SRR25158203_k127_2355202_6	387631.Asulf_02196	3.617e-35	140.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,24687@183980|Archaeoglobi	183980|Archaeoglobi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
SRR25158203_k127_2355202_4	1094980.Mpsy_2504	8.918e-103	344.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2N9HH@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0388	vATP-synt_AC39
SRR25158203_k127_2355202_7	1094980.Mpsy_2505	6.875e-31	123.0	COG1436@1|root,arCOG04102@2157|Archaea,2XXYI@28890|Euryarchaeota,2N9YY@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
SRR25158203_k127_2355202_0	1094980.Mpsy_2506	1.609e-301	932.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2N93M@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SRR25158203_k127_2355202_1	1094980.Mpsy_2507	4.446e-264	817.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2N97D@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SRR25158203_k127_2355202_5	1094980.Mpsy_2508	1.381e-89	299.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,2N9IG@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0384	ATP-synt_D
SRR25158203_k127_2355202_3	574375.BAGA_09130	5.604e-110	367.0	COG3227@1|root,COG3227@2|Bacteria,1TP08@1239|Firmicutes,4H9S6@91061|Bacilli,1ZM5E@1386|Bacillus	91061|Bacilli	E	Thermolysin metallopeptidase, catalytic domain	gelE	-	3.4.24.28,3.4.24.30	ko:K01400,ko:K08605	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FTP,PepSY,Peptidase_M4,Peptidase_M4_C
SRR25158203_k127_2383148_1	1041930.Mtc_1739	2.09e-67	233.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,2N9T0@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
SRR25158203_k127_2383148_3	1094980.Mpsy_2113	2.168e-27	114.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,2NA0Z@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
SRR25158203_k127_2383148_4	351160.LRC36	7.955e-27	115.0	COG3612@1|root,arCOG04418@2157|Archaea,2XXT8@28890|Euryarchaeota,2NA4A@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
SRR25158203_k127_2383148_2	1094980.Mpsy_0874	5.16e-36	142.0	arCOG06570@1|root,arCOG06570@2157|Archaea,2Y5X3@28890|Euryarchaeota,2NBD1@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2383148_0	192952.MM_3299	8.462e-68	238.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
SRR25158203_k127_2408260_1	1094980.Mpsy_1889	1.464e-45	171.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
SRR25158203_k127_2408260_2	192952.MM_2631	4.087e-41	154.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,2N9TM@224756|Methanomicrobia	224756|Methanomicrobia	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
SRR25158203_k127_2408260_3	706587.Desti_0173	2.009e-33	133.0	COG0509@1|root,COG0509@2|Bacteria,1NYE8@1224|Proteobacteria,430NZ@68525|delta/epsilon subdivisions,2WW4N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Glycine cleavage system H protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SRR25158203_k127_2408260_4	1343739.PAP_00220	6.818e-24	106.0	COG0509@1|root,arCOG01303@2157|Archaea,2XY1B@28890|Euryarchaeota,24409@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SRR25158203_k127_2408260_0	420324.KI911994_gene8036	4.717e-102	351.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria	1224|Proteobacteria	L	Resolvase	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
SRR25158203_k127_2418778_1	304371.MCP_1488	6.693e-96	318.0	COG3328@1|root,arCOG04918@2157|Archaea	2157|Archaea	L	PFAM Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
SRR25158203_k127_2418778_2	693661.Arcve_1632	5.573e-20	94.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SRR25158203_k127_2418778_0	351160.RCIX2455	7.896e-166	529.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N92K@224756|Methanomicrobia	224756|Methanomicrobia	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
SRR25158203_k127_242200_5	192952.MM_2608	1.604e-33	131.0	COG1669@1|root,arCOG01206@2157|Archaea,2Y29X@28890|Euryarchaeota,2NBBA@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM DNA polymerase beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_242200_4	192952.MM_2607	3.394e-39	149.0	COG2361@1|root,arCOG05024@2157|Archaea,2XYV1@28890|Euryarchaeota,2NBBR@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SRR25158203_k127_242200_2	671143.DAMO_2589	4.776e-65	229.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
SRR25158203_k127_242200_1	679926.Mpet_1380	2.543e-103	353.0	COG1672@1|root,arCOG03166@2157|Archaea,2XTP2@28890|Euryarchaeota,2N9VA@224756|Methanomicrobia	224756|Methanomicrobia	S	ATPase domain predominantly from Archaea	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
SRR25158203_k127_242200_0	1094980.Mpsy_2086	1.001e-191	606.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
SRR25158203_k127_242200_3	247490.KSU1_D0012	3.988e-43	168.0	COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,2J2QC@203682|Planctomycetes	203682|Planctomycetes	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4
SRR25158203_k127_2462624_3	1094980.Mpsy_2207	1.305e-92	310.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,2N9MR@224756|Methanomicrobia	224756|Methanomicrobia	Q	PFAM tRNA methyltransferase complex GCD14 subunit	pimT	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,Methyltransf_31,PCMT
SRR25158203_k127_2462624_13	192952.MM_2053	2.049e-19	92.0	arCOG03394@1|root,arCOG03394@2157|Archaea,2Y1QT@28890|Euryarchaeota,2NA3E@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2462624_2	192952.MM_2494	5.453e-130	423.0	COG1060@1|root,arCOG00657@2157|Archaea,2XT78@28890|Euryarchaeota,2N94M@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofG	-	2.5.1.77	ko:K11780	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
SRR25158203_k127_2462624_1	1094980.Mpsy_2558	5.462e-132	430.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota,2N942@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH	-	2.5.1.77	ko:K11781	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
SRR25158203_k127_2462624_10	269797.Mbar_A1169	2.437e-27	116.0	arCOG03097@1|root,arCOG03097@2157|Archaea,2Y0PX@28890|Euryarchaeota,2N9YB@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2462624_18	693661.Arcve_0856	2.369e-08	57.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y130@28890|Euryarchaeota,246GP@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2462624_12	1041930.Mtc_1611	8.473e-24	103.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota,2NBEM@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SRR25158203_k127_2462624_15	797303.Natpe_0012	1.072e-12	79.0	arCOG04555@1|root,arCOG04555@2157|Archaea,2XUY2@28890|Euryarchaeota,23TMB@183963|Halobacteria	183963|Halobacteria	S	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
SRR25158203_k127_2462624_14	234267.Acid_0807	1.44e-18	97.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
SRR25158203_k127_2462624_17	1210884.HG799467_gene13181	1.573e-11	75.0	COG4932@1|root,COG4932@2|Bacteria,2IYDU@203682|Planctomycetes	203682|Planctomycetes	M	Cna B domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
SRR25158203_k127_2462624_8	269797.Mbar_A3465	1.434e-35	139.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,2N9UK@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM ribosomal protein S8E	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
SRR25158203_k127_2462624_4	351160.RCIX2051	6.805e-45	176.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,2N99C@224756|Methanomicrobia	224756|Methanomicrobia	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	bchP	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3
SRR25158203_k127_2462624_6	592015.HMPREF1705_00648	4.433e-42	164.0	COG0095@1|root,COG0095@2|Bacteria,3TBDG@508458|Synergistetes	508458|Synergistetes	H	PFAM Biotin lipoate A B protein ligase family	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SRR25158203_k127_2462624_16	891968.Anamo_1112	2.59e-12	71.0	COG0095@1|root,COG0095@2|Bacteria	2|Bacteria	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SRR25158203_k127_2462624_9	436308.Nmar_1155	7.939e-34	132.0	COG0640@1|root,arCOG01681@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	merR	-	2.1.1.137	ko:K07755,ko:K21903	-	-	-	-	ko00000,ko01000,ko03000	-	-	-	HTH_5
SRR25158203_k127_2462624_0	671143.DAMO_0464	4.639e-293	926.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
SRR25158203_k127_2462624_19	192952.MM_0859	3.236e-07	58.0	arCOG01060@1|root,arCOG01060@2157|Archaea,2Y63R@28890|Euryarchaeota,2NBB4@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2462624_5	1227500.C494_11335	2.988e-42	158.0	COG0599@1|root,arCOG02148@2157|Archaea,2XYCN@28890|Euryarchaeota,23W7U@183963|Halobacteria	183963|Halobacteria	S	homolog of gamma-carboxymuconolactone decarboxylase subunit	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_2491502_1	304371.MCP_1427	2.928e-111	369.0	arCOG01220@1|root,arCOG01220@2157|Archaea,2XYGI@28890|Euryarchaeota,2N9S5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PrmA
SRR25158203_k127_2491502_0	697282.Mettu_0517	5.946e-233	729.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,1T9X2@1236|Gammaproteobacteria,1XG04@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2491502_2	1162668.LFE_2212	1.712e-07	53.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
SRR25158203_k127_2510641_2	1122947.FR7_4418	4.028e-84	285.0	COG0600@1|root,COG0600@2|Bacteria,1TQVZ@1239|Firmicutes,4H5AI@909932|Negativicutes	909932|Negativicutes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SRR25158203_k127_2510641_1	431943.CKL_1039	1.381e-93	313.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,36GMS@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SRR25158203_k127_2510641_0	436308.Nmar_0471	2.943e-180	589.0	COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
SRR25158203_k127_2510641_3	192952.MM_1280	1.547e-73	253.0	COG0177@1|root,arCOG00459@2157|Archaea	2157|Archaea	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF123,EndIII_4Fe-2S,HhH-GPD
SRR25158203_k127_2516116_12	489825.LYNGBM3L_03930	1.141e-20	99.0	COG3299@1|root,COG3299@2|Bacteria,1G6J6@1117|Cyanobacteria,1HBV9@1150|Oscillatoriales	1117|Cyanobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
SRR25158203_k127_2516116_1	502025.Hoch_3608	3.639e-141	488.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42Q9A@68525|delta/epsilon subdivisions,2WM4B@28221|Deltaproteobacteria,2YVXE@29|Myxococcales	28221|Deltaproteobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
SRR25158203_k127_2516116_11	1195236.CTER_3471	1.202e-37	145.0	COG3628@1|root,COG3628@2|Bacteria,1VCD7@1239|Firmicutes,24P2S@186801|Clostridia,3WM0T@541000|Ruminococcaceae	186801|Clostridia	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
SRR25158203_k127_2516116_6	1195236.CTER_3472	1.961e-62	216.0	COG4104@1|root,COG4104@2|Bacteria,1VUNW@1239|Firmicutes,24GP3@186801|Clostridia	186801|Clostridia	S	PAAR motif	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
SRR25158203_k127_2516116_4	489825.LYNGBM3L_03970	5.217e-79	269.0	COG3501@1|root,COG3501@2|Bacteria,1G6H3@1117|Cyanobacteria,1HBBA@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Phage-related baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2516116_3	1034769.KB910518_gene1551	1.19e-86	298.0	COG3500@1|root,COG3500@2|Bacteria,1V1XA@1239|Firmicutes,4HGPH@91061|Bacilli,26RWA@186822|Paenibacillaceae	91061|Bacilli	S	Phage protein D	-	-	-	ko:K06905	-	-	-	-	ko00000	-	-	-	Phage_GPD
SRR25158203_k127_2516116_8	1034769.KB910518_gene1550	2.689e-46	174.0	COG1652@1|root,COG1652@2|Bacteria,1V83T@1239|Firmicutes,4HJ06@91061|Bacilli,26VCS@186822|Paenibacillaceae	91061|Bacilli	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
SRR25158203_k127_2516116_9	755731.Clo1100_1275	8.449e-44	163.0	2DMQT@1|root,32T2H@2|Bacteria,1VA81@1239|Firmicutes,24EAU@186801|Clostridia,36QIQ@31979|Clostridiaceae	186801|Clostridia	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
SRR25158203_k127_2516116_13	1195236.CTER_3477a	4.538e-20	91.0	arCOG11411@1|root,33A8Q@2|Bacteria,1VM7Z@1239|Firmicutes,24W4Z@186801|Clostridia,3WMQJ@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2516116_7	1291050.JAGE01000001_gene2789	1.895e-54	192.0	arCOG11412@1|root,31S84@2|Bacteria,1V6H1@1239|Firmicutes,24K0T@186801|Clostridia,3WKD6@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2516116_5	1034769.KB910518_gene1545	1.078e-63	221.0	2DB76@1|root,2Z7JZ@2|Bacteria,1V5UY@1239|Firmicutes,4HI95@91061|Bacilli,26X82@186822|Paenibacillaceae	91061|Bacilli	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
SRR25158203_k127_2516116_0	1195236.CTER_3480	2.711e-197	626.0	COG3497@1|root,COG3497@2|Bacteria,1TNY8@1239|Firmicutes,24BH8@186801|Clostridia,3WHN0@541000|Ruminococcaceae	186801|Clostridia	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
SRR25158203_k127_2516116_10	1034769.KB910518_gene1543	1.708e-41	159.0	2E7AK@1|root,331U1@2|Bacteria,1V9QD@1239|Firmicutes,4HJRQ@91061|Bacilli,26XD8@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
SRR25158203_k127_2516116_2	1195236.CTER_3482	3.017e-134	437.0	COG0464@1|root,COG0464@2|Bacteria,1TQXY@1239|Firmicutes,24AK2@186801|Clostridia,3WI7P@541000|Ruminococcaceae	186801|Clostridia	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
SRR25158203_k127_2528965_0	1121472.AQWN01000001_gene77	0.0	1309.0	COG0610@1|root,COG0610@2|Bacteria,1TP7S@1239|Firmicutes,248A6@186801|Clostridia,2610J@186807|Peptococcaceae	186801|Clostridia	V	Subunit R is required for both nuclease and ATPase activities, but not for modification	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
SRR25158203_k127_2528965_3	192952.MM_0247	4.715e-66	231.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,2N9J9@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A2079	CBS,HTH_3
SRR25158203_k127_2528965_2	1041930.Mtc_0068	2.86e-67	233.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,2N9MZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SRR25158203_k127_2528965_1	269797.Mbar_A1372	9.72e-84	282.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,2N9JI@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
SRR25158203_k127_2529498_1	1232437.KL662061_gene4151	1.56e-113	376.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42SXS@68525|delta/epsilon subdivisions,2X5BQ@28221|Deltaproteobacteria,2MPUV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
SRR25158203_k127_2529498_2	403833.Pmob_0833	3.531e-34	134.0	2CAI9@1|root,32W0I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2529498_0	1047013.AQSP01000121_gene2714	1.107e-276	861.0	COG0286@1|root,COG0286@2|Bacteria,2NNMG@2323|unclassified Bacteria	2|Bacteria	V	HsdM N-terminal domain	hsdM	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HTH_3,HTH_31,HsdM_N,N6_Mtase
SRR25158203_k127_2529498_3	679926.Mpet_2551	2.398e-11	64.0	arCOG10446@1|root,arCOG10446@2157|Archaea,2Y1MQ@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
SRR25158203_k127_2538275_2	1121422.AUMW01000010_gene1060	2.759e-68	240.0	COG2048@1|root,COG2048@2|Bacteria,1U4JW@1239|Firmicutes,24C8P@186801|Clostridia,260T4@186807|Peptococcaceae	186801|Clostridia	C	heterodisulfide reductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SRR25158203_k127_2538275_6	237368.SCABRO_01879	1.027e-35	143.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
SRR25158203_k127_2538275_3	335543.Sfum_1176	2.62e-60	222.0	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MR23@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SRR25158203_k127_2538275_5	269797.Mbar_A0896	5.414e-44	165.0	COG4055@1|root,arCOG04859@2157|Archaea,2XZ5V@28890|Euryarchaeota,2NBJT@224756|Methanomicrobia	224756|Methanomicrobia	H	Methyl-coenzyme M reductase operon protein D	mcrD	-	-	ko:K03422	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	MCR_D
SRR25158203_k127_2538275_0	192952.MM_1489	6.329e-210	656.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N918@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SRR25158203_k127_2538275_4	269797.Mbar_A0804	5.007e-58	209.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,2N9QB@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	-	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
SRR25158203_k127_2538275_1	192952.MM_2223	1.384e-126	415.0	COG0463@1|root,arCOG00894@2157|Archaea,2XUJ6@28890|Euryarchaeota,2NAND@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR25158203_k127_254599_2	1123277.KB893228_gene1981	1.247e-27	117.0	28JJ9@1|root,2Z9CC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_254599_3	386456.JQKN01000002_gene2635	9.192e-14	74.0	COG4033@1|root,arCOG04844@2157|Archaea,2XYZ8@28890|Euryarchaeota,23PP2@183925|Methanobacteria	183925|Methanobacteria	S	Domain of unknown function (DUF1894)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1894
SRR25158203_k127_254599_1	456442.Mboo_2094	1.18e-42	161.0	COG4081@1|root,arCOG04845@2157|Archaea,2XXFT@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1890
SRR25158203_k127_254599_0	1094980.Mpsy_1302	8.485e-65	227.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,2N9CU@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
SRR25158203_k127_2565146_4	368407.Memar_2161	1.847e-41	157.0	arCOG04987@1|root,arCOG04987@2157|Archaea,2Y4XS@28890|Euryarchaeota,2NB7M@224756|Methanomicrobia	224756|Methanomicrobia	S	Peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2565146_2	368407.Memar_2162	1.244e-54	201.0	COG3398@1|root,arCOG02611@2157|Archaea,2XV4M@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24
SRR25158203_k127_2565146_0	760568.Desku_2938	6.306e-82	281.0	COG2998@1|root,COG2998@2|Bacteria,1TQA9@1239|Firmicutes,249EZ@186801|Clostridia,2605W@186807|Peptococcaceae	186801|Clostridia	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
SRR25158203_k127_2565146_3	1230457.C476_02992	3.274e-53	196.0	COG4662@1|root,arCOG00166@2157|Archaea,2XTDY@28890|Euryarchaeota,23TEJ@183963|Halobacteria	183963|Halobacteria	P	ABC-type tungstate transport system, periplasmic component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
SRR25158203_k127_2565146_1	529709.PYCH_04570	4.625e-69	243.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7NF@28890|Euryarchaeota,242VD@183968|Thermococci	183968|Thermococci	G	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
SRR25158203_k127_2565146_5	1101195.Meth11DRAFT_0289	1.885e-31	126.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,2KKKZ@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
SRR25158203_k127_2568979_5	192952.MM_1005	2.749e-45	169.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,2NBGT@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
SRR25158203_k127_2568979_7	290402.Cbei_1502	2.555e-36	139.0	COG0599@1|root,COG0599@2|Bacteria,1V846@1239|Firmicutes,24NC0@186801|Clostridia,36KYB@31979|Clostridiaceae	186801|Clostridia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_2568979_8	269797.Mbar_A1272	5.625e-25	107.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
SRR25158203_k127_2568979_6	269797.Mbar_A2848	1.493e-40	154.0	COG1661@1|root,arCOG04212@2157|Archaea,2XZVT@28890|Euryarchaeota,2NA04@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
SRR25158203_k127_2568979_9	1094980.Mpsy_0644	1.032e-05	59.0	arCOG02542@1|root,arCOG10954@1|root,arCOG02542@2157|Archaea,arCOG10954@2157|Archaea,2XV12@28890|Euryarchaeota	28890|Euryarchaeota	U	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	-	-	-	-	-	-	-	-	-	-	Glug
SRR25158203_k127_2568979_1	243231.GSU1538	2.51e-157	505.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
SRR25158203_k127_2568979_0	1094980.Mpsy_2933	5.368e-201	631.0	COG0137@1|root,arCOG00112@2157|Archaea,2XU8K@28890|Euryarchaeota,2N9DR@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
SRR25158203_k127_2568979_4	198467.NP92_06685	5.816e-106	350.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4HA2J@91061|Bacilli,21VBA@150247|Anoxybacillus	91061|Bacilli	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU16100	CoA_binding,Ligase_CoA
SRR25158203_k127_2568979_2	926569.ANT_20580	1.282e-107	359.0	COG0045@1|root,COG0045@2|Bacteria,2G68A@200795|Chloroflexi	200795|Chloroflexi	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SRR25158203_k127_2568979_3	1094980.Mpsy_1079	4e-106	348.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,2N975@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the ATCase OTCase family	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SRR25158203_k127_2572969_2	1094980.Mpsy_1932	4.295e-137	443.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,2N91F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM DEAD_2 domain protein	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
SRR25158203_k127_2572969_0	1041930.Mtc_2119	0.0	1008.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,2N99U@224756|Methanomicrobia	224756|Methanomicrobia	S	KH, type 1, domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
SRR25158203_k127_2572969_3	1094980.Mpsy_2881	5.341e-89	297.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
SRR25158203_k127_2572969_1	1094980.Mpsy_2719	4.786e-233	729.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,2N95X@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0179	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SRR25158203_k127_2572969_5	269797.Mbar_A1346	3.023e-35	136.0	COG3293@1|root,arCOG03506@2157|Archaea	2157|Archaea	L	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF4096
SRR25158203_k127_2572969_4	269797.Mbar_A1346	1.207e-58	206.0	COG3293@1|root,arCOG03506@2157|Archaea	2157|Archaea	L	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF4096
SRR25158203_k127_2572969_6	269797.Mbar_A1346	5.476e-19	87.0	COG3293@1|root,arCOG03506@2157|Archaea	2157|Archaea	L	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF4096
SRR25158203_k127_2583917_0	1094980.Mpsy_1635	2.65e-233	737.0	COG0175@1|root,arCOG02449@1|root,arCOG00073@2157|Archaea,arCOG02449@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
SRR25158203_k127_2583917_1	1041930.Mtc_2102	3.243e-09	63.0	arCOG00381@1|root,arCOG00381@2157|Archaea,2XV5B@28890|Euryarchaeota,2NAYN@224756|Methanomicrobia	224756|Methanomicrobia	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2587795_13	1487953.JMKF01000069_gene148	7.835e-06	51.0	COG2801@1|root,COG2801@2|Bacteria,1G5GD@1117|Cyanobacteria,1HGQD@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
SRR25158203_k127_2587795_2	1167006.UWK_02103	3.056e-97	327.0	COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,42TZD@68525|delta/epsilon subdivisions,2WQIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Phosphonate ABC transporter, periplasmic	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
SRR25158203_k127_2587795_5	667014.Thein_0411	1.55e-56	218.0	COG4191@1|root,COG4191@2|Bacteria,2GHNA@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,PAS_4,PAS_9
SRR25158203_k127_2587795_6	1121918.ARWE01000001_gene2617	5.263e-51	188.0	COG2204@1|root,COG2204@2|Bacteria,1RKBV@1224|Proteobacteria,43079@68525|delta/epsilon subdivisions,2WV79@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRR25158203_k127_2587795_12	192952.MM_2583	1.41e-12	68.0	COG1826@1|root,arCOG02694@2157|Archaea,2XZZ6@28890|Euryarchaeota,2NB5U@224756|Methanomicrobia	224756|Methanomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SRR25158203_k127_2587795_0	187272.Mlg_0216	4.737e-234	751.0	COG0243@1|root,COG0243@2|Bacteria,1R5ZE@1224|Proteobacteria,1S1Y2@1236|Gammaproteobacteria,1X2D4@135613|Chromatiales	135613|Chromatiales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
SRR25158203_k127_2587795_4	1379698.RBG1_1C00001G0856	7.528e-70	243.0	COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
SRR25158203_k127_2587795_3	693661.Arcve_1690	1.095e-72	259.0	COG5557@1|root,arCOG02025@2157|Archaea,2XWFI@28890|Euryarchaeota,246T1@183980|Archaeoglobi	183980|Archaeoglobi	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
SRR25158203_k127_2587795_9	222984.JNCS01000007_gene429	7.329e-19	93.0	arCOG01506@1|root,arCOG01506@2157|Archaea,2XX2Q@28890|Euryarchaeota,23VVC@183963|Halobacteria	183963|Halobacteria	S	component of anaerobic dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
SRR25158203_k127_2587795_14	323097.Nham_1924	1.312e-05	54.0	2CP7W@1|root,32SIM@2|Bacteria,1MZAF@1224|Proteobacteria,2UD6E@28211|Alphaproteobacteria,3JZ2A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2587795_11	521011.Mpal_2722	3.476e-13	71.0	arCOG09502@1|root,arCOG09502@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2587795_8	521011.Mpal_2721	7.697e-43	167.0	arCOG02322@1|root,arCOG02322@2157|Archaea	2157|Archaea	T	methyl-accepting chemotaxis protein	-	-	2.7.13.3	ko:K03406,ko:K07652	ko02020,ko02030,map02020,map02030	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,MCPsignal,PAS_9,dCache_3,sCache_3_3
SRR25158203_k127_2587795_7	419665.Maeo_0270	3.161e-44	172.0	COG0226@1|root,arCOG00213@2157|Archaea,2XU6M@28890|Euryarchaeota,23Q0S@183939|Methanococci	183939|Methanococci	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SRR25158203_k127_2587795_10	247490.KSU1_D1013	1.549e-13	70.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,2J0FA@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
SRR25158203_k127_2587795_1	1094980.Mpsy_2035	1.199e-97	321.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,2N9DT@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0254	Bac_luciferase
SRR25158203_k127_2598629_1	1094980.Mpsy_2247	1.673e-218	691.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR25158203_k127_2598629_3	351160.RRC178	1.312e-58	205.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
SRR25158203_k127_2598629_2	1094980.Mpsy_1109	1.214e-109	363.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,2N9C9@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
SRR25158203_k127_2598629_0	1094980.Mpsy_2704	1.889e-260	821.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
SRR25158203_k127_2606379_2	1132509.C447_00770	3.214e-130	428.0	COG0477@1|root,arCOG00130@2157|Archaea,2XTYA@28890|Euryarchaeota,23TB9@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRR25158203_k127_2606379_1	192952.MM_0047	3.631e-167	535.0	COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2NBNP@224756|Methanomicrobia	224756|Methanomicrobia	E	Aminotransferase class-III	-	-	2.6.1.19,2.6.1.76	ko:K00823,ko:K00836	ko00250,ko00260,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00410,map00640,map00650,map01100,map01120,map01210,map01230	M00027,M00033	R00908,R01648,R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SRR25158203_k127_2606379_0	192952.MM_0048	4.025e-230	721.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,2NA9G@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Aldehyde dehydrogenase	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
SRR25158203_k127_2606915_0	1094980.Mpsy_2741	7.318e-146	476.0	COG4231@1|root,arCOG01612@2157|Archaea,2XWAR@28890|Euryarchaeota,2N95R@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C,TPP_enzyme_N
SRR25158203_k127_2606915_1	192952.MM_2789	1.507e-121	396.0	COG1571@1|root,arCOG01116@2157|Archaea,2XTUY@28890|Euryarchaeota,2N933@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF1743)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1743
SRR25158203_k127_2606915_2	693661.Arcve_1724	1.374e-61	222.0	COG1750@1|root,arCOG01937@2157|Archaea,2XUEB@28890|Euryarchaeota,245RX@183980|Archaeoglobi	183980|Archaeoglobi	O	Belongs to the peptidase S16 family	-	-	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
SRR25158203_k127_2614284_2	1121403.AUCV01000012_gene4109	7.212e-43	168.0	COG1075@1|root,COG1075@2|Bacteria,1QD4I@1224|Proteobacteria,435MR@68525|delta/epsilon subdivisions,2X9BC@28221|Deltaproteobacteria,2MNSY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2614284_3	1500259.JQLD01000001_gene3974	1.982e-22	105.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria,4BCYP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
SRR25158203_k127_2614284_0	247490.KSU1_B0448	3.075e-90	299.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	flr	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SRR25158203_k127_2614284_1	1094980.Mpsy_2111	9.57e-74	254.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,2N9NN@224756|Methanomicrobia	224756|Methanomicrobia	Q	methyltransferase small	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
SRR25158203_k127_2615113_13	1459636.NTE_03124	9.904e-26	116.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
SRR25158203_k127_2615113_5	386456.JQKN01000013_gene3060	2.512e-119	405.0	COG1502@1|root,arCOG02041@2157|Archaea	2157|Archaea	I	Phospholipase D Transphosphatidylase	-	-	-	ko:K06131,ko:K06132,ko:K06915	ko00564,ko01100,map00564,map01100	-	R07390,R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
SRR25158203_k127_2615113_7	237368.SCABRO_00580	1.894e-81	283.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CBM9_2,DUF362
SRR25158203_k127_2615113_11	234267.Acid_0434	4.507e-49	188.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	choD	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,FAD_oxidored,GMC_oxred_C,GMC_oxred_N
SRR25158203_k127_2615113_8	237368.SCABRO_00580	2.382e-81	283.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CBM9_2,DUF362
SRR25158203_k127_2615113_15	1283299.AUKG01000002_gene3738	5.706e-05	49.0	28WQB@1|root,2ZIQ0@2|Bacteria,2INA2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2615113_14	192952.MM_0371	6.527e-12	76.0	arCOG03321@1|root,arCOG03321@2157|Archaea,2Y3WV@28890|Euryarchaeota,2NATQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2615113_3	1094980.Mpsy_0115	2.552e-152	486.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,2NA7N@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SRR25158203_k127_2615113_6	1094980.Mpsy_0116	4.978e-102	342.0	COG1721@1|root,arCOG02745@2157|Archaea,2XVGA@28890|Euryarchaeota,2NAC9@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SRR25158203_k127_2615113_4	269797.Mbar_A1934	1.525e-123	418.0	arCOG02905@1|root,arCOG02905@2157|Archaea,2XU82@28890|Euryarchaeota,2NANS@224756|Methanomicrobia	224756|Methanomicrobia	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA
SRR25158203_k127_2615113_2	192952.MM_0375	9.605e-175	576.0	arCOG02907@1|root,arCOG02907@2157|Archaea,2XVFW@28890|Euryarchaeota,2NAD7@224756|Methanomicrobia	224756|Methanomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
SRR25158203_k127_2615113_10	1041930.Mtc_2154	5.143e-52	184.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,2N9T3@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
SRR25158203_k127_2615113_1	192952.MM_2264	2.232e-213	668.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SRR25158203_k127_2615113_0	1094980.Mpsy_1014	0.0	1096.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,2N9FS@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SRR25158203_k127_2615113_12	926569.ANT_20270	1.512e-33	141.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR25158203_k127_2615113_9	386456.JQKN01000001_gene1847	1.98e-68	237.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,23PGN@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	EF-hand_5,Peptidase_M48
SRR25158203_k127_2644484_4	373903.Hore_22330	1.402e-16	81.0	2DG7P@1|root,2ZUUE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2644484_1	404380.Gbem_1630	1.742e-116	380.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,42UQ1@68525|delta/epsilon subdivisions,2WQWP@28221|Deltaproteobacteria,43VZM@69541|Desulfuromonadales	28221|Deltaproteobacteria	EH	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
SRR25158203_k127_2644484_2	1047013.AQSP01000139_gene2368	4.978e-69	243.0	COG0730@1|root,COG0730@2|Bacteria,2NRZN@2323|unclassified Bacteria	2|Bacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRR25158203_k127_2644484_0	1128398.Curi_c25190	5.059e-124	409.0	COG2895@1|root,COG2895@2|Bacteria,1UI8R@1239|Firmicutes,249BX@186801|Clostridia,26AXX@186813|unclassified Clostridiales	186801|Clostridia	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SRR25158203_k127_2644484_5	342949.PNA2_1058	5.313e-10	69.0	arCOG01380@1|root,arCOG01380@2157|Archaea,2XWDR@28890|Euryarchaeota,243VH@183968|Thermococci	183968|Thermococci	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
SRR25158203_k127_2644484_3	398767.Glov_2755	1.666e-48	187.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	exoA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K16557	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
SRR25158203_k127_2644581_13	1296416.JACB01000026_gene3943	2.958e-13	74.0	COG0732@1|root,COG0732@2|Bacteria,4NK11@976|Bacteroidetes,1IGGV@117743|Flavobacteriia,2YKUS@290174|Aquimarina	976|Bacteroidetes	V	Type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
SRR25158203_k127_2644581_10	765911.Thivi_4007	3.117e-16	81.0	2ED63@1|root,3372T@2|Bacteria,1NEJK@1224|Proteobacteria,1SD1X@1236|Gammaproteobacteria,1WZG9@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2644581_3	289376.THEYE_A1691	1.093e-35	139.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
SRR25158203_k127_2644581_18	698757.Pogu_1213	2.616e-08	59.0	COG1708@1|root,arCOG01195@2157|Archaea,2XRAN@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_2644581_17	289376.THEYE_A1692	1.753e-10	64.0	COG0732@1|root,COG0732@2|Bacteria	2|Bacteria	V	type I restriction modification DNA specificity domain	hsdS	-	3.1.21.3	ko:K01153,ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
SRR25158203_k127_2644581_2	589924.Ferp_0908	1.018e-51	188.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y6E8@28890|Euryarchaeota,2473X@183980|Archaeoglobi	183980|Archaeoglobi	V	nucleic acid-binding protein contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2644581_5	589924.Ferp_0909	1.227e-35	137.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2Y8J1@28890|Euryarchaeota,247IF@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
SRR25158203_k127_2644581_11	1227454.C446_08816	3.04e-15	80.0	arCOG14112@1|root,arCOG14112@2157|Archaea,2Y0BR@28890|Euryarchaeota,23XT7@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2644581_15	1410668.JNKC01000001_gene1927	2.038e-12	68.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,36MNT@31979|Clostridiaceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
SRR25158203_k127_2644581_7	192952.MM_2919	8.436e-25	106.0	COG0599@1|root,arCOG02151@2157|Archaea,2Y0W0@28890|Euryarchaeota,2NB47@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_2644581_8	552811.Dehly_0135	1.242e-19	97.0	COG0500@1|root,COG2226@2|Bacteria,2G9AJ@200795|Chloroflexi,34D6A@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Methyltransferase domain	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_25
SRR25158203_k127_2644581_14	1444310.JANV01000032_gene679	1.3e-12	70.0	COG0425@1|root,COG0425@2|Bacteria,1VEEC@1239|Firmicutes,4HNQT@91061|Bacilli,1ZI1V@1386|Bacillus	91061|Bacilli	O	Belongs to the sulfur carrier protein TusA family	yrkI	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	-	-	-	-	-	-	-	-	-	TusA
SRR25158203_k127_2644581_9	877455.Metbo_1610	4.237e-19	91.0	COG1695@1|root,arCOG00001@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SRR25158203_k127_2644581_4	913865.DOT_3283	1.135e-35	148.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
SRR25158203_k127_2644581_6	706587.Desti_2024	1.75e-27	128.0	COG0784@1|root,COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MQW1@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_2644581_12	386456.JQKN01000021_gene26	6.796e-14	85.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SRR25158203_k127_2644581_1	192952.MM_1387	2.206e-54	198.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
SRR25158203_k127_2644581_0	386456.JQKN01000008_gene1592	1.033e-198	623.0	COG0641@1|root,arCOG00945@2157|Archaea,2XV96@28890|Euryarchaeota,23NRU@183925|Methanobacteria	183925|Methanobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
SRR25158203_k127_2644581_16	1123371.ATXH01000018_gene1376	3.128e-11	64.0	COG1028@1|root,COG1028@2|Bacteria,2GH4K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRR25158203_k127_2673393_3	269797.Mbar_A2931	1.45e-49	204.0	COG3291@1|root,arCOG06836@1|root,arCOG02546@2157|Archaea,arCOG06836@2157|Archaea	2157|Archaea	P	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	BNR_2,CARDB,Kelch_4,PKD,VWA
SRR25158203_k127_2673393_1	439235.Dalk_4098	9.599e-64	236.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,43BFP@68525|delta/epsilon subdivisions,2X6U3@28221|Deltaproteobacteria,2MPIH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
SRR25158203_k127_2673393_0	1094980.Mpsy_1552	1.028e-162	518.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,2N946@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
SRR25158203_k127_2673393_2	269797.Mbar_A0877	2.184e-59	208.0	COG1051@1|root,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,2N9US@224756|Methanomicrobia	224756|Methanomicrobia	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SRR25158203_k127_2673393_4	1041930.Mtc_1269	2.578e-30	122.0	COG1594@1|root,arCOG00579@2157|Archaea,2XY3E@28890|Euryarchaeota,2N9ZZ@224756|Methanomicrobia	224756|Methanomicrobia	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	tfs	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
SRR25158203_k127_2677606_8	67352.JODS01000001_gene168	1.3e-10	74.0	COG3469@1|root,COG3469@2|Bacteria,2GJTU@201174|Actinobacteria	201174|Actinobacteria	G	alpha-galactosidase	-	-	3.2.1.14,3.2.1.4	ko:K01179,ko:K01183	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R01206,R02334,R06200,R11307,R11308	RC00467	ko00000,ko00001,ko01000	-	GH18,GH5,GH9	-	CBM_2,CBM_4_9,Calx-beta,Cellulase,Glyco_hydro_18,PE,fn3
SRR25158203_k127_2677606_6	1254432.SCE1572_22375	2.238e-21	108.0	COG3055@1|root,COG3227@1|root,COG4412@1|root,COG3055@2|Bacteria,COG3227@2|Bacteria,COG4412@2|Bacteria,1QT4U@1224|Proteobacteria,437RQ@68525|delta/epsilon subdivisions,2X4KF@28221|Deltaproteobacteria,2YZ72@29|Myxococcales	28221|Deltaproteobacteria	E	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2677606_1	1094980.Mpsy_0523	1.848e-67	239.0	COG4743@1|root,arCOG02884@2157|Archaea,2XU3K@28890|Euryarchaeota,2N99A@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1616
SRR25158203_k127_2677606_4	192952.MM_1186	1.928e-41	162.0	COG1266@1|root,arCOG02769@2157|Archaea,2XYZF@28890|Euryarchaeota,2NAQ7@224756|Methanomicrobia	224756|Methanomicrobia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
SRR25158203_k127_2677606_2	471852.Tcur_3586	1.922e-62	222.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria,4EJ5R@85012|Streptosporangiales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR25158203_k127_2677606_0	192952.MM_0424	1.188e-154	498.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,2N985@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
SRR25158203_k127_2677606_7	1220534.B655_1877	2.416e-13	74.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,23PHY@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
SRR25158203_k127_2677606_5	386456.JQKN01000002_gene2774	1.446e-40	153.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,23PHY@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
SRR25158203_k127_2677606_3	933262.AXAM01000002_gene504	3.581e-46	171.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SRR25158203_k127_2688833_3	1380763.BG53_00890	2.069e-05	51.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23
SRR25158203_k127_2688833_2	304371.MCP_1186	9.548e-60	213.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,2N9TJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
SRR25158203_k127_2688833_0	589924.Ferp_0226	1.289e-120	394.0	COG2006@1|root,arCOG02446@2157|Archaea,2XV9B@28890|Euryarchaeota,245XE@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SRR25158203_k127_2688833_1	179408.Osc7112_6903	1.72e-70	257.0	COG5412@1|root,COG5412@2|Bacteria,1G08D@1117|Cyanobacteria,1H9PT@1150|Oscillatoriales	1117|Cyanobacteria	M	phage tail tape measure protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
SRR25158203_k127_2722463_8	251229.Chro_2890	1.788e-37	143.0	2DGVE@1|root,32U82@2|Bacteria,1G87Z@1117|Cyanobacteria,3VMSH@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2722463_14	1121285.AUFK01000006_gene1945	8.973e-16	82.0	2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,1I02M@117743|Flavobacteriia,3ZRNW@59732|Chryseobacterium	976|Bacteroidetes	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2722463_20	1550091.JROE01000032_gene4176	4.567e-05	47.0	2EHME@1|root,33BD6@2|Bacteria,4NY3V@976|Bacteroidetes,1J001@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2722463_18	591158.SSMG_04411	1.506e-05	47.0	2E4EA@1|root,3068J@2|Bacteria,2GZWZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2722463_7	596152.DesU5LDRAFT_2681	2.485e-38	145.0	2DN97@1|root,32W7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2722463_0	192952.MM_1307	4.378e-122	402.0	COG1423@1|root,arCOG04218@2157|Archaea,2XUD4@28890|Euryarchaeota,2NAK8@224756|Methanomicrobia	224756|Methanomicrobia	L	RNA ligase	-	-	6.5.1.1	ko:K07468	-	-	R00381	RC00005	ko00000,ko01000	-	-	-	RNA_ligase
SRR25158203_k127_2722463_2	192952.MM_1305	1.574e-88	299.0	COG0517@1|root,arCOG00600@2157|Archaea,2XYA3@28890|Euryarchaeota,2N9Q4@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_2722463_3	269797.Mbar_A0967	2.466e-76	265.0	COG0517@1|root,arCOG00600@2157|Archaea,2XXMJ@28890|Euryarchaeota,2N9JW@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
SRR25158203_k127_2722463_1	1094980.Mpsy_2124	7.676e-93	314.0	COG0517@1|root,arCOG00600@2157|Archaea,2XX02@28890|Euryarchaeota,2N9I1@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_2722463_4	192952.MM_1302	1.642e-73	256.0	COG0517@1|root,arCOG00602@2157|Archaea,2XYM5@28890|Euryarchaeota,2N9RH@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_2722463_6	351160.RCIX1863	1.294e-38	152.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_2722463_10	593750.Metfor_0833	4.894e-21	94.0	COG1598@1|root,arCOG02411@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SRR25158203_k127_2722463_11	395493.BegalDRAFT_3181	1.37e-20	93.0	COG1724@1|root,COG1724@2|Bacteria,1NB5I@1224|Proteobacteria,1STWS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
SRR25158203_k127_2722463_5	192952.MM_3225	5.606e-66	233.0	COG1028@1|root,arCOG01259@2157|Archaea,2Y67R@28890|Euryarchaeota,2NAMS@224756|Methanomicrobia	224756|Methanomicrobia	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
SRR25158203_k127_2740830_2	589924.Ferp_0670	8.839e-89	331.0	arCOG08705@1|root,arCOG08705@2157|Archaea	2157|Archaea	-	-	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	-
SRR25158203_k127_2740830_0	644282.Deba_1938	2.276e-182	580.0	COG2848@1|root,COG2848@2|Bacteria,1NAFG@1224|Proteobacteria,42NH7@68525|delta/epsilon subdivisions,2WJJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
SRR25158203_k127_2740830_3	647113.Metok_1109	1.85e-20	93.0	COG3830@1|root,arCOG04941@2157|Archaea,2Y0AS@28890|Euryarchaeota,23R57@183939|Methanococci	183939|Methanococci	T	Belongs to the UPF0237 family	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
SRR25158203_k127_2740830_1	192952.MM_1418	1.111e-149	483.0	COG3635@1|root,arCOG01696@2157|Archaea,2XU1U@28890|Euryarchaeota,2N95W@224756|Methanomicrobia	224756|Methanomicrobia	G	phosphoglycerate mutase	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
SRR25158203_k127_2740830_4	1094980.Mpsy_1108	3.17e-20	96.0	arCOG04419@1|root,arCOG04419@2157|Archaea,2XZTP@28890|Euryarchaeota,2NA22@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2551)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2551
SRR25158203_k127_2748176_0	269797.Mbar_A3234	2.177e-81	278.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SRR25158203_k127_2748176_1	1094980.Mpsy_2773	1.142e-80	273.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,2N9MM@224756|Methanomicrobia	224756|Methanomicrobia	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
SRR25158203_k127_2748176_4	269797.Mbar_A3232	1.878e-36	140.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,2N9UM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
SRR25158203_k127_2748176_3	269797.Mbar_A3231	2.313e-37	142.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,2N9X1@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
SRR25158203_k127_2748176_2	192952.MM_2535	6.418e-54	195.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
SRR25158203_k127_2777124_2	192952.MM_2519	5.372e-62	215.0	COG1161@1|root,arCOG00350@2157|Archaea,2XWAE@28890|Euryarchaeota,2NA9B@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF258	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
SRR25158203_k127_2777124_4	313628.LNTAR_10656	7.188e-10	60.0	COG4895@1|root,COG4895@2|Bacteria	2|Bacteria	S	conserved protein (DUF2196)	ywbE	-	-	-	-	-	-	-	-	-	-	-	DUF2196
SRR25158203_k127_2777124_0	926690.KE386573_gene1249	0.0	1036.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23RXX@183963|Halobacteria	183963|Halobacteria	O	COG0464 ATPases of the AAA class	cdc48a	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
SRR25158203_k127_2777124_3	1094980.Mpsy_2000	1.989e-23	102.0	COG1873@1|root,arCOG02155@2157|Archaea,2XYZ2@28890|Euryarchaeota,2NA15@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
SRR25158203_k127_2777124_1	269797.Mbar_A2181	4.414e-64	226.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,2N9S6@224756|Methanomicrobia	224756|Methanomicrobia	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
SRR25158203_k127_2789239_2	1094980.Mpsy_2374	3.924e-86	287.0	COG0451@1|root,arCOG01369@2157|Archaea,2XVMJ@28890|Euryarchaeota,2NAHV@224756|Methanomicrobia	224756|Methanomicrobia	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SRR25158203_k127_2789239_1	1094980.Mpsy_2065	4.828e-90	302.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,2N96I@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM bifunctional deaminase-reductase domain protein	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
SRR25158203_k127_2789239_0	304371.MCP_1803	1.774e-98	330.0	COG0053@1|root,arCOG01474@2157|Archaea,2XU96@28890|Euryarchaeota,2NAZZ@224756|Methanomicrobia	224756|Methanomicrobia	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
SRR25158203_k127_2789239_6	269797.Mbar_A1318	4.812e-30	121.0	COG3377@1|root,arCOG04424@2157|Archaea,2Y0SF@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF1805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1805
SRR25158203_k127_2789239_12	102125.Xen7305DRAFT_00053810	0.0001907	45.0	COG2336@1|root,COG2336@2|Bacteria,1GA24@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM SpoVT AbrB like domain	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
SRR25158203_k127_2789239_7	1094980.Mpsy_1253	1.979e-26	111.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y49G@28890|Euryarchaeota,2NAXH@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2789239_3	243231.GSU0487	5.376e-70	246.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42MJ0@68525|delta/epsilon subdivisions,2WKKK@28221|Deltaproteobacteria,43SA5@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TIGRFAM cation diffusion facilitator family transporter	dmeF	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
SRR25158203_k127_2789239_8	1094980.Mpsy_2264	6.275e-25	104.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
SRR25158203_k127_2789239_9	1094980.Mpsy_2259	1.248e-22	97.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
SRR25158203_k127_2789239_10	192952.MM_1357	2.525e-21	96.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota,2NA53@224756|Methanomicrobia	224756|Methanomicrobia	S	TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
SRR25158203_k127_2789239_5	269797.Mbar_A1249	7.314e-43	161.0	COG0235@1|root,arCOG04226@2157|Archaea,2XX1T@28890|Euryarchaeota,2NBHV@224756|Methanomicrobia	224756|Methanomicrobia	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1249	Aldolase_II
SRR25158203_k127_2789239_4	547144.HydHO_0636	7.566e-52	186.0	COG1793@1|root,COG1793@2|Bacteria	2|Bacteria	L	dna ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
SRR25158203_k127_2811699_19	521011.Mpal_1150	5.439e-20	93.0	arCOG09458@1|root,arCOG09458@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2811699_6	1499967.BAYZ01000028_gene1315	1.606e-107	358.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SRR25158203_k127_2811699_7	1499967.BAYZ01000028_gene1314	1.462e-100	337.0	COG0573@1|root,COG0573@2|Bacteria,2NPS2@2323|unclassified Bacteria	2|Bacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SRR25158203_k127_2811699_10	1499967.BAYZ01000028_gene1313	3.614e-95	319.0	COG0581@1|root,COG0581@2|Bacteria,2NPJS@2323|unclassified Bacteria	2|Bacteria	P	phosphate transport system permease protein	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SRR25158203_k127_2811699_5	1499967.BAYZ01000028_gene1312	5.012e-111	369.0	COG1117@1|root,COG1117@2|Bacteria,2NP2B@2323|unclassified Bacteria	2|Bacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27,3.6.3.55	ko:K02036,ko:K02068,ko:K06857	ko02010,map02010	M00186,M00211,M00222	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4,3.A.1.7	-	-	ABC_tran
SRR25158203_k127_2811699_12	1173026.Glo7428_1817	7.64e-75	259.0	COG0730@1|root,COG0730@2|Bacteria,1G72I@1117|Cyanobacteria	1117|Cyanobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRR25158203_k127_2811699_11	351160.RRC3	3.175e-87	293.0	COG0518@1|root,arCOG00090@2157|Archaea,2XTYN@28890|Euryarchaeota,2N9MH@224756|Methanomicrobia	224756|Methanomicrobia	F	Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1837	GATase
SRR25158203_k127_2811699_21	1163730.FFONT_0293	3.79e-12	72.0	COG0517@1|root,arCOG00606@2157|Archaea,2XR8I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_2811699_20	306281.AJLK01000130_gene5636	5.03e-19	89.0	COG4231@1|root,COG4231@2|Bacteria,1GQ0I@1117|Cyanobacteria,1JIVS@1189|Stigonemataceae	1117|Cyanobacteria	C	4Fe-4S dicluster domain	fdxB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
SRR25158203_k127_2811699_1	877455.Metbo_2414	5.753e-136	445.0	COG2710@1|root,arCOG00594@2157|Archaea,2XUNU@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the NifD NifK NifE NifN family	-	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
SRR25158203_k127_2811699_0	632335.Calkr_1795	2.004e-191	606.0	COG2710@1|root,COG2710@2|Bacteria,1TQUW@1239|Firmicutes,248JD@186801|Clostridia,42EWG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM oxidoreductase nitrogenase, component 1	anfD	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
SRR25158203_k127_2811699_18	645991.Sgly_2842	2.44e-35	141.0	COG0347@1|root,COG0347@2|Bacteria,1V73J@1239|Firmicutes,24KI5@186801|Clostridia,2620Y@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the P(II) protein family	-	-	-	ko:K02590	-	-	-	-	ko00000	-	-	-	P-II
SRR25158203_k127_2811699_17	1094508.Tsac_2236	2.689e-40	151.0	COG0347@1|root,COG0347@2|Bacteria,1VASB@1239|Firmicutes,24J84@186801|Clostridia,42H0M@68295|Thermoanaerobacterales	186801|Clostridia	K	Belongs to the P(II) protein family	-	-	-	ko:K02589	-	-	-	-	ko00000	-	-	-	P-II
SRR25158203_k127_2811699_2	192952.MM_0719	4.508e-134	431.0	COG1348@1|root,arCOG00590@2157|Archaea,2XUM3@28890|Euryarchaeota,2N99X@224756|Methanomicrobia	224756|Methanomicrobia	D	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	-	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
SRR25158203_k127_2811699_16	192952.MM_2014	3.457e-41	153.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,2NA1A@224756|Methanomicrobia	224756|Methanomicrobia	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a-2	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
SRR25158203_k127_2811699_24	565033.GACE_1023	3.012e-05	50.0	COG0582@1|root,arCOG01242@2157|Archaea,2Y83U@28890|Euryarchaeota,246MT@183980|Archaeoglobi	2157|Archaea	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase,zinc_ribbon_2
SRR25158203_k127_2811699_14	1041930.Mtc_0528	1.091e-54	194.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
SRR25158203_k127_2811699_22	387631.Asulf_00148	3.079e-06	51.0	arCOG06141@1|root,arCOG06141@2157|Archaea,2Y28R@28890|Euryarchaeota	28890|Euryarchaeota	S	Family of unknown function (DUF5371)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5371
SRR25158203_k127_2811699_8	1094980.Mpsy_2657	2.053e-97	324.0	COG0179@1|root,arCOG00235@2157|Archaea,2XU30@28890|Euryarchaeota,2N9DN@224756|Methanomicrobia	224756|Methanomicrobia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
SRR25158203_k127_2811699_4	1094980.Mpsy_3166	2.249e-114	374.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,2N986@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
SRR25158203_k127_2811699_9	269797.Mbar_A1392	7.703e-97	328.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,2N925@224756|Methanomicrobia	224756|Methanomicrobia	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
SRR25158203_k127_2811699_13	443144.GM21_0128	7.61e-67	233.0	COG3861@1|root,COG3861@2|Bacteria,1QE0P@1224|Proteobacteria,42TDZ@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
SRR25158203_k127_2811699_15	351160.LRC56	1.288e-49	181.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,2N9S2@224756|Methanomicrobia	224756|Methanomicrobia	J	ribosomal protein S15	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
SRR25158203_k127_2811699_3	1094980.Mpsy_2686	3.73e-126	417.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,2N9D2@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
SRR25158203_k127_2811699_23	1094980.Mpsy_2685	8.642e-06	52.0	arCOG01354@1|root,arCOG01354@2157|Archaea	2157|Archaea	-	-	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Pcc1
SRR25158203_k127_281765_7	1273538.G159_04945	6.707e-10	69.0	2950P@1|root,2ZYQG@2|Bacteria,1V5HG@1239|Firmicutes,4HI30@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_281765_6	269799.Gmet_2410	4.892e-16	80.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,43VQC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Iron/manganese superoxide dismutases, C-terminal domain	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
SRR25158203_k127_281765_2	671143.DAMO_0395	1.651e-89	298.0	COG0605@1|root,COG0605@2|Bacteria,2NP62@2323|unclassified Bacteria	2|Bacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
SRR25158203_k127_281765_4	269797.Mbar_A1085	5.105e-25	109.0	COG1935@1|root,arCOG04420@2157|Archaea,2Y1FM@28890|Euryarchaeota,2NA37@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF473)	-	-	-	ko:K09135	-	-	-	-	ko00000	-	-	-	DUF473
SRR25158203_k127_281765_1	1094980.Mpsy_1456	1.259e-91	307.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
SRR25158203_k127_281765_5	1094980.Mpsy_2469	6.071e-20	94.0	COG3874@1|root,arCOG04972@2157|Archaea	2157|Archaea	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
SRR25158203_k127_281765_8	269797.Mbar_A0807	1.478e-09	66.0	arCOG03505@1|root,arCOG03505@2157|Archaea,2Y6XT@28890|Euryarchaeota,2NBBG@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2953)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2953
SRR25158203_k127_281765_0	1173024.KI912149_gene5262	2.503e-199	659.0	COG1816@1|root,COG2202@1|root,COG2204@1|root,COG4191@1|root,COG5278@1|root,COG1816@2|Bacteria,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,COG5278@2|Bacteria,1GK1J@1117|Cyanobacteria,1JKBT@1189|Stigonemataceae	1117|Cyanobacteria	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_9,Response_reg
SRR25158203_k127_281765_3	1094980.Mpsy_2191	3.165e-60	212.0	COG0826@1|root,arCOG03202@2157|Archaea,2XVBU@28890|Euryarchaeota	28890|Euryarchaeota	O	Peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
SRR25158203_k127_283659_0	192952.MM_0836	1.045e-87	299.0	COG1232@1|root,arCOG01522@2157|Archaea,2XVES@28890|Euryarchaeota,2NAMB@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SRR25158203_k127_2847316_8	269797.Mbar_A3274	5.365e-20	91.0	COG4096@1|root,arCOG00880@2157|Archaea,2XUEI@28890|Euryarchaeota,2N9C8@224756|Methanomicrobia	224756|Methanomicrobia	V	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,Helicase_C,ResIII
SRR25158203_k127_2847316_1	1094980.Mpsy_2380	8.352e-228	722.0	COG0175@1|root,COG2221@1|root,arCOG00073@2157|Archaea,arCOG02059@2157|Archaea,2Y7JD@28890|Euryarchaeota,2N9AR@224756|Methanomicrobia	224756|Methanomicrobia	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,PAPS_reduct
SRR25158203_k127_2847316_0	247490.KSU1_C0716	2.302e-247	782.0	COG0514@1|root,COG0514@2|Bacteria,2IX4R@203682|Planctomycetes	203682|Planctomycetes	L	DEAD DEAH box helicase	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
SRR25158203_k127_2847316_5	1089553.Tph_c19520	2.395e-59	218.0	COG1856@1|root,COG1856@2|Bacteria,1V23U@1239|Firmicutes,24E3M@186801|Clostridia,42GSP@68295|Thermoanaerobacterales	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
SRR25158203_k127_2847316_6	351160.RCIX1504	1.969e-25	115.0	COG1266@1|root,arCOG02769@2157|Archaea	2157|Archaea	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi,TPR_12
SRR25158203_k127_2847316_9	1094980.Mpsy_0255	1.464e-17	95.0	COG0467@1|root,arCOG01175@2157|Archaea,2XUNH@28890|Euryarchaeota,2NAZW@224756|Methanomicrobia	224756|Methanomicrobia	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SRR25158203_k127_2847316_7	1047013.AQSP01000109_gene2440	3.289e-24	106.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
SRR25158203_k127_2847316_2	1047013.AQSP01000109_gene2441	1.328e-110	363.0	COG0500@1|root,COG2226@2|Bacteria,2NP8K@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	arsM	-	2.1.1.137,2.1.1.79	ko:K00574,ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
SRR25158203_k127_2847316_10	479434.Sthe_3143	8.235e-05	46.0	COG1145@1|root,32YX2@2|Bacteria,2G9TA@200795|Chloroflexi	200795|Chloroflexi	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2847316_3	1094980.Mpsy_1487	1.721e-108	356.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MI@28890|Euryarchaeota,2NBNK@224756|Methanomicrobia	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SRR25158203_k127_2847316_4	593750.Metfor_0114	9.754e-71	242.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,2N9J0@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM riboflavin synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
SRR25158203_k127_2859844_3	933262.AXAM01000030_gene825	7.192e-22	95.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,2MJ4J@213118|Desulfobacterales	28221|Deltaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3
SRR25158203_k127_2859844_1	1121918.ARWE01000001_gene2617	4.36e-48	179.0	COG2204@1|root,COG2204@2|Bacteria,1RKBV@1224|Proteobacteria,43079@68525|delta/epsilon subdivisions,2WV79@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRR25158203_k127_2859844_0	1041930.Mtc_0774	1.381e-89	314.0	COG0517@1|root,COG0750@1|root,arCOG00607@2157|Archaea,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,2N9D0@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
SRR25158203_k127_2859844_5	1121952.ATXT01000015_gene122	1.384e-07	65.0	COG1874@1|root,COG1874@2|Bacteria,2GIUX@201174|Actinobacteria,4FMZY@85023|Microbacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolases family 35	-	-	-	-	-	-	-	-	-	-	-	-	BetaGal_dom2,BetaGal_dom3,BetaGal_dom4_5,Glyco_hydro_35
SRR25158203_k127_2859844_4	1094980.Mpsy_0384	9.508e-10	72.0	arCOG03269@1|root,arCOG03269@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF11,PKD
SRR25158203_k127_2859844_2	693661.Arcve_1632	1.911e-23	102.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SRR25158203_k127_2874293_7	1365176.N186_00730	0.0004604	43.0	COG1249@1|root,arCOG01068@2157|Archaea,2XPKZ@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRR25158203_k127_2874293_2	472759.Nhal_2949	1.478e-88	304.0	COG2128@1|root,COG2128@2|Bacteria,1N82C@1224|Proteobacteria,1RQQI@1236|Gammaproteobacteria,1X06J@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF3179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3179
SRR25158203_k127_2874293_4	472759.Nhal_2950	2.185e-18	92.0	arCOG09065@1|root,336SW@2|Bacteria,1NEV2@1224|Proteobacteria,1SQ46@1236|Gammaproteobacteria,1X14U@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2874293_5	1274374.CBLK010000047_gene1978	7.848e-12	70.0	COG3794@1|root,COG3794@2|Bacteria,1VGNY@1239|Firmicutes,4HQS7@91061|Bacilli,275D5@186822|Paenibacillaceae	91061|Bacilli	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
SRR25158203_k127_2874293_3	1094980.Mpsy_0275	9.158e-41	156.0	COG3794@1|root,arCOG02924@1|root,arCOG02924@2157|Archaea,arCOG02929@2157|Archaea,2Y1NH@28890|Euryarchaeota,2NB8Y@224756|Methanomicrobia	224756|Methanomicrobia	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRR25158203_k127_2874293_0	1027292.HMPREF9372_3725	1.892e-124	413.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4HBZR@91061|Bacilli,26GQA@186818|Planococcaceae	91061|Bacilli	H	Resistance to Hg(2 ) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0)	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	HMA,Pyr_redox_2,Pyr_redox_dim
SRR25158203_k127_2874293_1	387631.Asulf_02006	3.508e-103	348.0	COG0535@1|root,arCOG00940@2157|Archaea	2157|Archaea	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
SRR25158203_k127_28976_0	1410616.JHXE01000001_gene2499	2.016e-103	343.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,3NH38@46205|Pseudobutyrivibrio	186801|Clostridia	E	Phenazine biosynthesis-like protein	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SRR25158203_k127_28976_1	290397.Adeh_2295	3.938e-99	329.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,42Y9Q@68525|delta/epsilon subdivisions,2WTQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
SRR25158203_k127_2906199_6	269797.Mbar_A2087	2.421e-20	93.0	COG1810@1|root,arCOG02468@2157|Archaea,2XU42@28890|Euryarchaeota,2NAEU@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF166
SRR25158203_k127_2906199_3	304371.MCP_0612	8.029e-64	224.0	COG1522@1|root,arCOG01580@2157|Archaea,2XXQR@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SRR25158203_k127_2906199_1	316067.Geob_1235	9.397e-85	287.0	COG1145@1|root,COG1145@2|Bacteria,1PW12@1224|Proteobacteria,42MZ9@68525|delta/epsilon subdivisions,2WN0W@28221|Deltaproteobacteria,43SWA@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
SRR25158203_k127_2906199_4	521011.Mpal_0033	2.36e-25	107.0	COG4033@1|root,arCOG04844@2157|Archaea,2XYZ8@28890|Euryarchaeota,2NB73@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF1894)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1894
SRR25158203_k127_2906199_7	1094980.Mpsy_1302	5.028e-12	68.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,2N9CU@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
SRR25158203_k127_2906199_5	1094980.Mpsy_2943	1.637e-21	94.0	COG1035@1|root,arCOG02653@2157|Archaea,2XUJW@28890|Euryarchaeota,2N9GU@224756|Methanomicrobia	224756|Methanomicrobia	C	coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein	-	-	1.17.1.9	ko:K00125	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_17,FrhB_FdhB_C,FrhB_FdhB_N
SRR25158203_k127_2906199_0	1094980.Mpsy_1039	1.287e-101	340.0	COG2218@1|root,arCOG00098@2157|Archaea,2XVBM@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM glutamate synthase alpha subunit	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
SRR25158203_k127_2906199_2	404589.Anae109_3161	2.572e-65	238.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase A domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,sCache_3_2
SRR25158203_k127_2920105_3	269797.Mbar_A3474	1.357e-12	68.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,2NAHP@224756|Methanomicrobia	224756|Methanomicrobia	O	Clp protease	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
SRR25158203_k127_2920105_0	192952.MM_0690	3.067e-85	294.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
SRR25158203_k127_2920105_1	656519.Halsa_1509	3.242e-39	149.0	COG4818@1|root,COG4818@2|Bacteria,1VBIZ@1239|Firmicutes,24XCH@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
SRR25158203_k127_2920105_2	593750.Metfor_2530	2.539e-30	128.0	arCOG09579@1|root,arCOG09579@2157|Archaea,2Y58J@28890|Euryarchaeota,2NBAR@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2952859_3	891968.Anamo_1108	2.603e-25	115.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	lytH	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	DUF3289,Peptidase_M23
SRR25158203_k127_2952859_0	1094980.Mpsy_1003	1.044e-138	452.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,2N91D@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent	dadD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
SRR25158203_k127_2952859_5	1158318.ATXC01000002_gene1619	1.925e-07	57.0	2EIPJ@1|root,33CEZ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
SRR25158203_k127_2952859_1	870187.Thini_3469	4.184e-30	130.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
SRR25158203_k127_2952859_2	1041930.Mtc_2102	1.103e-25	121.0	arCOG00381@1|root,arCOG00381@2157|Archaea,2XV5B@28890|Euryarchaeota,2NAYN@224756|Methanomicrobia	224756|Methanomicrobia	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2952859_6	304371.MCP_2365	9.243e-05	46.0	arCOG00381@1|root,arCOG00381@2157|Archaea,2XV5B@28890|Euryarchaeota,2NAYN@224756|Methanomicrobia	224756|Methanomicrobia	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2952859_4	693661.Arcve_1631	2.285e-15	83.0	COG0467@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,2XXH5@28890|Euryarchaeota	28890|Euryarchaeota	T	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
SRR25158203_k127_2963281_1	868131.MSWAN_0026	1.072e-21	98.0	COG1520@1|root,arCOG02482@2157|Archaea,2XUI1@28890|Euryarchaeota,23NSA@183925|Methanobacteria	183925|Methanobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
SRR25158203_k127_2963281_0	673860.AciM339_1442	3.567e-136	445.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,3F35P@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	aor1	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SRR25158203_k127_2969039_6	269797.Mbar_A2011	2.219e-05	50.0	COG3291@1|root,arCOG03259@2157|Archaea,2Y7NK@28890|Euryarchaeota,2NACD@224756|Methanomicrobia	2157|Archaea	S	cell wall organization	-	-	-	-	-	-	-	-	-	-	-	-	DUF4430,Prenyltrans,S-layer
SRR25158203_k127_2969039_3	1041930.Mtc_0131	1.003e-47	176.0	COG1370@1|root,arCOG00991@2157|Archaea,2XYFT@28890|Euryarchaeota,2N9W0@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PUA domain containing protein	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
SRR25158203_k127_2969039_1	269797.Mbar_A0366	5.257e-159	514.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,2N9DZ@224756|Methanomicrobia	224756|Methanomicrobia	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
SRR25158203_k127_2969039_5	1094980.Mpsy_1616	1.686e-07	54.0	arCOG04992@1|root,arCOG04992@2157|Archaea,2Y5MQ@28890|Euryarchaeota,2NBA9@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2969039_2	1094980.Mpsy_1615	1.053e-55	198.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,2N9QK@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
SRR25158203_k127_2969039_0	1094980.Mpsy_0047	3.174e-165	529.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2N97V@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
SRR25158203_k127_2969039_4	485913.Krac_9856	4.586e-22	100.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
SRR25158203_k127_2973510_6	269797.Mbar_A3365	1.405e-06	54.0	COG1277@1|root,arCOG02436@2157|Archaea,2Y02D@28890|Euryarchaeota,2NBG9@224756|Methanomicrobia	28890|Euryarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
SRR25158203_k127_2973510_0	269797.Mbar_A3369	1.171e-180	579.0	COG1470@1|root,arCOG02081@2157|Archaea,2Y7MM@28890|Euryarchaeota,2NBC7@224756|Methanomicrobia	224756|Methanomicrobia	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
SRR25158203_k127_2973510_2	269797.Mbar_A3370	5.749e-142	456.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,2NAHY@224756|Methanomicrobia	224756|Methanomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR25158203_k127_2973510_5	1123325.JHUV01000015_gene235	1.587e-10	63.0	COG2005@1|root,COG4148@1|root,COG2005@2|Bacteria,COG4148@2|Bacteria,2G4WG@200783|Aquificae	200783|Aquificae	H	TOBE domain	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,TOBE
SRR25158203_k127_2973510_4	269797.Mbar_A1265	6.972e-24	104.0	COG2005@1|root,arCOG00223@2157|Archaea,2Y7ND@28890|Euryarchaeota,2NA3N@224756|Methanomicrobia	224756|Methanomicrobia	S	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,TOBE
SRR25158203_k127_2973510_7	1121438.JNJA01000001_gene2650	0.0002646	46.0	COG4575@1|root,COG4575@2|Bacteria,1PZKE@1224|Proteobacteria,4317K@68525|delta/epsilon subdivisions,2WWXQ@28221|Deltaproteobacteria,2MCF9@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
SRR25158203_k127_2973510_1	1094980.Mpsy_2179	1.98e-154	493.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,2N9C4@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SRR25158203_k127_2973510_3	269797.Mbar_A1514	4.372e-124	402.0	COG0107@1|root,arCOG00617@2157|Archaea,2XU22@28890|Euryarchaeota,2N987@224756|Methanomicrobia	224756|Methanomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1514	His_biosynth
SRR25158203_k127_297463_5	1041930.Mtc_1611	4.99e-28	115.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota,2NBEM@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SRR25158203_k127_297463_1	1094980.Mpsy_1653	4.191e-105	348.0	arCOG03474@1|root,arCOG03474@2157|Archaea,2Y3J6@28890|Euryarchaeota,2NBJC@224756|Methanomicrobia	28890|Euryarchaeota	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SRR25158203_k127_297463_2	1121403.AUCV01000060_gene3725	9.717e-69	238.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,42RSQ@68525|delta/epsilon subdivisions,2WNED@28221|Deltaproteobacteria,2MJRX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM HPP family	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
SRR25158203_k127_297463_3	439235.Dalk_3566	1.406e-35	142.0	COG3448@1|root,COG3448@2|Bacteria,1Q1A8@1224|Proteobacteria,42SIQ@68525|delta/epsilon subdivisions,2WPF0@28221|Deltaproteobacteria,2MKBJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_297463_4	445972.ANACOL_03261	5.461e-32	134.0	COG2159@1|root,COG2159@2|Bacteria,1VB68@1239|Firmicutes,24PD1@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
SRR25158203_k127_297463_0	247490.KSU1_D0613	3.338e-105	349.0	COG2221@1|root,COG2221@2|Bacteria,2J35G@203682|Planctomycetes	203682|Planctomycetes	C	Nitrite/Sulfite reductase ferredoxin-like half domain	-	-	-	-	-	-	-	-	-	-	-	-	NIR_SIR_ferr
SRR25158203_k127_297463_7	237368.SCABRO_03618	4.465e-22	97.0	COG0425@1|root,COG0425@2|Bacteria,2J3XY@203682|Planctomycetes	203682|Planctomycetes	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
SRR25158203_k127_297463_6	443144.GM21_0983	1.303e-27	118.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WJ68@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Multi-haem_cyto
SRR25158203_k127_2975312_1	1459636.NTE_00644	1.143e-22	104.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2975312_0	1094980.Mpsy_1425	2.973e-181	574.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
SRR25158203_k127_2975312_3	565033.GACE_0735	3.348e-08	62.0	COG3432@1|root,arCOG01055@2157|Archaea,2Y15R@28890|Euryarchaeota,247GS@183980|Archaeoglobi	183980|Archaeoglobi	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR25158203_k127_2975312_2	1094980.Mpsy_1184	1.493e-21	111.0	arCOG02538@1|root,arCOG02544@1|root,arCOG06534@1|root,arCOG02538@2157|Archaea,arCOG02544@2157|Archaea,arCOG06534@2157|Archaea,2Y6ZG@28890|Euryarchaeota,2NAWQ@224756|Methanomicrobia	2157|Archaea	S	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,NosD,PKD,PQQ_3,Peptidase_S8,S-layer
SRR25158203_k127_2975312_4	1041930.Mtc_0259	2.358e-07	59.0	arCOG09579@1|root,arCOG09579@2157|Archaea,2Y58J@28890|Euryarchaeota,2NBAR@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2990297_2	867903.ThesuDRAFT_00932	9.872e-17	84.0	COG2250@1|root,COG2250@2|Bacteria,1VEAZ@1239|Firmicutes,24Q6D@186801|Clostridia	186801|Clostridia	S	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
SRR25158203_k127_2990297_0	304371.MCP_1925	1.02e-180	574.0	COG1625@1|root,arCOG00950@2157|Archaea,2XTIR@28890|Euryarchaeota,2N94K@224756|Methanomicrobia	224756|Methanomicrobia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SRR25158203_k127_2990297_1	1173022.Cri9333_1031	1.605e-173	557.0	COG0784@1|root,COG3852@1|root,COG4566@1|root,COG0784@2|Bacteria,COG3852@2|Bacteria,COG4566@2|Bacteria,1GHJE@1117|Cyanobacteria,1HHX1@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_2992767_1	192952.MM_2209	1.412e-165	534.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,2N951@224756|Methanomicrobia	224756|Methanomicrobia	S	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
SRR25158203_k127_2992767_0	1094980.Mpsy_2341	0.0	1249.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SRR25158203_k127_2992767_16	1313421.JHBV01000039_gene2725	1.358e-06	55.0	COG0727@1|root,COG0727@2|Bacteria,4NJH9@976|Bacteroidetes,1ITJ5@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SRR25158203_k127_2992767_13	386456.JQKN01000014_gene3102	7.132e-37	145.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota	28890|Euryarchaeota	S	zinc metalloprotease whose natural substrate is	amzA	GO:0003674,GO:0003824,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0071704,GO:0140096,GO:1901564	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
SRR25158203_k127_2992767_9	453591.Igni_0079	1.523e-66	233.0	COG2220@1|root,arCOG00497@2157|Archaea,2XQFG@28889|Crenarchaeota	28889|Crenarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
SRR25158203_k127_2992767_6	386456.JQKN01000004_gene148	6.602e-83	288.0	COG0784@1|root,arCOG06537@2157|Archaea,2XWYJ@28890|Euryarchaeota	28890|Euryarchaeota	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4,PAS_9,PadR,Response_reg
SRR25158203_k127_2992767_4	1220534.B655_0224	2.76e-99	344.0	COG0784@1|root,COG2203@1|root,COG3920@1|root,arCOG04001@1|root,arCOG06712@1|root,arCOG02335@2157|Archaea,arCOG02356@2157|Archaea,arCOG02357@2157|Archaea,arCOG04001@2157|Archaea,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SRR25158203_k127_2992767_14	192952.MM_1410	2.161e-34	149.0	arCOG03489@1|root,arCOG03489@2157|Archaea	192952.MM_1410|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2992767_15	186497.PF1864	2.445e-07	60.0	COG3316@1|root,arCOG02134@2157|Archaea,2XUAY@28890|Euryarchaeota	28890|Euryarchaeota	L	COG3316 Transposase and inactivated derivatives	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240,HTH_23
SRR25158203_k127_2992767_5	1094980.Mpsy_0113	4.033e-85	289.0	COG0077@1|root,arCOG00255@2157|Archaea,2XTAI@28890|Euryarchaeota,2N9DQ@224756|Methanomicrobia	224756|Methanomicrobia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
SRR25158203_k127_2992767_10	351160.RCIX631	8.006e-62	219.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,2N9NG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,MarR
SRR25158203_k127_2992767_7	1094980.Mpsy_1945	1.789e-82	281.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,2N9HB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1524	DHBP_synthase
SRR25158203_k127_2992767_12	304371.MCP_0085	1.725e-37	144.0	COG4738@1|root,arCOG04377@2157|Archaea,2XYIC@28890|Euryarchaeota,2NBJG@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_2992767_2	1094980.Mpsy_1548	2.943e-142	456.0	COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,2N9CI@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
SRR25158203_k127_2992767_8	192952.MM_0888	3.07e-78	269.0	COG0619@1|root,arCOG02250@2157|Archaea,2XXKA@28890|Euryarchaeota,2NAU8@224756|Methanomicrobia	224756|Methanomicrobia	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
SRR25158203_k127_2992767_3	192952.MM_0887	6.866e-103	341.0	COG1122@1|root,arCOG00202@2157|Archaea,2XT28@28890|Euryarchaeota,2NAFB@224756|Methanomicrobia	224756|Methanomicrobia	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
SRR25158203_k127_2992767_17	1220534.B655_1221	1.716e-05	56.0	COG0310@1|root,arCOG03159@2157|Archaea,2XYY3@28890|Euryarchaeota,23PTA@183925|Methanobacteria	183925|Methanobacteria	P	PDGLE domain	-	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	PDGLE
SRR25158203_k127_2992767_11	192952.MM_0893	6.89e-61	221.0	COG0310@1|root,arCOG02248@2157|Archaea,2XU97@28890|Euryarchaeota,2NAT4@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM protein	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
SRR25158203_k127_3026738_0	351160.RCIX76	1.929e-161	522.0	COG0665@1|root,arCOG00755@2157|Archaea,2XV4K@28890|Euryarchaeota,2NAF8@224756|Methanomicrobia	224756|Methanomicrobia	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
SRR25158203_k127_3026738_1	386456.JQKN01000008_gene1536	8.109e-76	261.0	arCOG10317@1|root,arCOG10317@2157|Archaea,2XWX7@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3034228_4	536232.CLM_3526	7.14e-64	225.0	COG1304@1|root,COG1304@2|Bacteria,1TPC4@1239|Firmicutes,249TX@186801|Clostridia,36F63@31979|Clostridiaceae	186801|Clostridia	C	FMN-dependent	lldD	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
SRR25158203_k127_3034228_1	1094980.Mpsy_1667	6.805e-245	766.0	COG0028@1|root,arCOG02002@2157|Archaea,2XT1P@28890|Euryarchaeota,2NAN7@224756|Methanomicrobia	224756|Methanomicrobia	E	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
SRR25158203_k127_3034228_2	1094980.Mpsy_1659	6.784e-177	565.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,2NA9G@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2542	Aldedh
SRR25158203_k127_3034228_0	269797.Mbar_A0714	0.0	1271.0	COG1048@1|root,arCOG01697@2157|Archaea,2XTIZ@28890|Euryarchaeota,2NAHN@224756|Methanomicrobia	224756|Methanomicrobia	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0714	Aconitase,Aconitase_C
SRR25158203_k127_3034228_3	584708.Apau_1398	5.445e-72	248.0	COG0740@1|root,COG0740@2|Bacteria,3T9R6@508458|Synergistetes	508458|Synergistetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
SRR25158203_k127_3043007_2	192952.MM_2889	2.619e-44	164.0	COG3431@1|root,arCOG04924@2157|Archaea,2XZ6G@28890|Euryarchaeota	28890|Euryarchaeota	S	Phosphate-starvation-inducible E	-	-	-	-	-	-	-	-	-	-	-	-	PsiE
SRR25158203_k127_3043007_1	419665.Maeo_0293	7.66e-70	246.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,23QJ2@183939|Methanococci	183939|Methanococci	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
SRR25158203_k127_3043007_4	88036.EFJ19654	4.923e-06	53.0	COG1916@1|root,KOG2860@2759|Eukaryota,37VWC@33090|Viridiplantae,3GPWA@35493|Streptophyta	35493|Streptophyta	T	TraB family	-	-	-	-	-	-	-	-	-	-	-	-	TraB
SRR25158203_k127_3043007_3	1094980.Mpsy_1732	8.517e-37	147.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,2N97A@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
SRR25158203_k127_3043007_0	909663.KI867150_gene1447	3.753e-136	444.0	COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,42N40@68525|delta/epsilon subdivisions,2WKUV@28221|Deltaproteobacteria,2MRT9@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
SRR25158203_k127_3061617_1	1094980.Mpsy_2671	2.207e-85	286.0	COG3344@1|root,arCOG03899@1|root,arCOG03317@2157|Archaea,arCOG03899@2157|Archaea,2XVTQ@28890|Euryarchaeota,2N984@224756|Methanomicrobia	224756|Methanomicrobia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1,RVT_N
SRR25158203_k127_3061617_0	221288.JH992901_gene2375	1.44e-178	599.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria,1JI0S@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SRR25158203_k127_31023_10	485917.Phep_3746	0.0002187	46.0	COG1361@1|root,COG2133@1|root,COG3291@1|root,COG4625@1|root,COG1361@2|Bacteria,COG2133@2|Bacteria,COG3291@2|Bacteria,COG4625@2|Bacteria,4NDZC@976|Bacteroidetes,1IRJP@117747|Sphingobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	CHU_C,DUF11,He_PIG,fn3
SRR25158203_k127_31023_7	589924.Ferp_0909	5.725e-20	92.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2Y8J1@28890|Euryarchaeota,247IF@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
SRR25158203_k127_31023_9	1235798.C817_03089	1.976e-05	48.0	COG2405@1|root,COG2405@2|Bacteria,1V7A0@1239|Firmicutes,25DC6@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF3368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
SRR25158203_k127_31023_4	579137.Metvu_1154	5.98e-25	108.0	arCOG06554@1|root,arCOG06554@2157|Archaea,2Y169@28890|Euryarchaeota,23RPZ@183939|Methanococci	183939|Methanococci	S	Family of unknown function (DUF5402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5402
SRR25158203_k127_31023_0	1094980.Mpsy_2191	5.762e-121	397.0	COG0826@1|root,arCOG03202@2157|Archaea,2XVBU@28890|Euryarchaeota	28890|Euryarchaeota	O	Peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
SRR25158203_k127_31023_1	1041930.Mtc_0169	2.386e-97	323.0	COG2140@1|root,arCOG02602@2157|Archaea,2XWS8@28890|Euryarchaeota,2N9IM@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Glucose-6-phosphate isomerase	gpi	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
SRR25158203_k127_31023_2	589865.DaAHT2_0048	2.924e-63	229.0	COG0755@1|root,COG0755@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
SRR25158203_k127_31023_5	304371.MCP_2831	3.515e-24	107.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2N9RC@224756|Methanomicrobia	224756|Methanomicrobia	H	adenyl ribonucleotide binding	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0975	AAA_17,RNA_binding
SRR25158203_k127_31023_3	224325.AF_1395	1.103e-59	211.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,245NW@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,RNA_binding
SRR25158203_k127_31023_8	1094980.Mpsy_2444	6.749e-16	81.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N947@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM 26S proteasome subunit P45 family	pan-1	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
SRR25158203_k127_3104240_0	1094980.Mpsy_2605	1.606e-228	716.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,2N94B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
SRR25158203_k127_3104240_2	1094980.Mpsy_1252	3.206e-54	195.0	COG0784@1|root,arCOG02594@2157|Archaea,2Y7NN@28890|Euryarchaeota,2NB1R@224756|Methanomicrobia	224756|Methanomicrobia	T	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_24,Response_reg
SRR25158203_k127_3104240_1	269797.Mbar_A1748	2.86e-130	425.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota,2N9QE@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the LDH MDH superfamily	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
SRR25158203_k127_3104240_4	192952.MM_2798	2.03e-08	56.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,2N9A6@224756|Methanomicrobia	224756|Methanomicrobia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
SRR25158203_k127_3109524_0	192952.MM_1539	3.489e-39	163.0	arCOG03489@1|root,arCOG03489@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3109524_1	1121456.ATVA01000011_gene1355	1.704e-12	75.0	COG0484@1|root,COG0484@2|Bacteria,1R72H@1224|Proteobacteria,42NCE@68525|delta/epsilon subdivisions,2WKDN@28221|Deltaproteobacteria,2M9A6@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM cytochrome c class III	hmcA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
SRR25158203_k127_3124464_4	247490.KSU1_C0755	3.389e-65	226.0	COG1592@1|root,COG1592@2|Bacteria,2J2TT@203682|Planctomycetes	203682|Planctomycetes	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SRR25158203_k127_3124464_7	1094980.Mpsy_1208	2.377e-31	127.0	COG0426@1|root,arCOG00509@2157|Archaea,2XYDW@28890|Euryarchaeota,2N9PY@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
SRR25158203_k127_3124464_0	868131.MSWAN_1536	2.423e-129	418.0	COG1600@1|root,arCOG02740@2157|Archaea,2Y2RT@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SRR25158203_k127_3124464_6	269797.Mbar_A0789	2.043e-40	163.0	arCOG03477@1|root,arCOG03477@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3124464_1	269797.Mbar_A0790	2.651e-126	414.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,2NB5Y@224756|Methanomicrobia	224756|Methanomicrobia	P	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SRR25158203_k127_3124464_3	269797.Mbar_A0791	1.163e-80	274.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2N9GV@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR25158203_k127_3124464_2	386456.JQKN01000001_gene1851	2.383e-83	286.0	COG2218@1|root,arCOG00098@2157|Archaea,2XVBM@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM glutamate synthase alpha subunit	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
SRR25158203_k127_3124464_5	404589.Anae109_2758	2.033e-52	192.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Cytochrome c oxidase, subunit I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
SRR25158203_k127_3129341_9	1094980.Mpsy_2187	1.187e-39	153.0	COG4061@1|root,arCOG04868@2157|Archaea,2XYI9@28890|Euryarchaeota,2N9JF@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrC	-	2.1.1.86	ko:K00579	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrC
SRR25158203_k127_3129341_5	1094980.Mpsy_2188	5.719e-67	235.0	COG4060@1|root,arCOG04869@2157|Archaea,2XWIA@28890|Euryarchaeota,2N9NI@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrD	-	2.1.1.86	ko:K00580	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrD
SRR25158203_k127_3129341_2	1094980.Mpsy_2189	6.195e-107	354.0	COG4059@1|root,arCOG04870@2157|Archaea,2XTGG@28890|Euryarchaeota,2N98Q@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrE	-	2.1.1.86	ko:K00581	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrE
SRR25158203_k127_3129341_0	269797.Mbar_A3491	7.156e-257	805.0	COG3158@1|root,arCOG05242@2157|Archaea,2Y37A@28890|Euryarchaeota,2NA90@224756|Methanomicrobia	224756|Methanomicrobia	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
SRR25158203_k127_3129341_6	406327.Mevan_0142	1.801e-61	237.0	COG0642@1|root,arCOG02358@2157|Archaea,2XVY8@28890|Euryarchaeota,23Q7U@183939|Methanococci	28890|Euryarchaeota	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,sCache_3_3
SRR25158203_k127_3129341_3	485916.Dtox_1919	1.588e-89	307.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260YA@186807|Peptococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,Oxidored_FMN,Pyr_redox_2
SRR25158203_k127_3129341_10	304371.MCP_0115	2.149e-38	147.0	COG1255@1|root,arCOG04385@2157|Archaea,2XYWU@28890|Euryarchaeota,2NBE6@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0146 family	-	-	-	ko:K09713	-	-	-	-	ko00000	-	-	-	UPF0146
SRR25158203_k127_3129341_4	1094980.Mpsy_2093	2.005e-82	280.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2XU3X@28890|Euryarchaeota,2NA0C@224756|Methanomicrobia	224756|Methanomicrobia	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3129341_1	693661.Arcve_1631	2.586e-130	426.0	COG0467@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,2XXH5@28890|Euryarchaeota	28890|Euryarchaeota	T	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
SRR25158203_k127_3129341_11	351160.RCIX296	1.347e-23	104.0	COG2018@1|root,arCOG02603@2157|Archaea	2157|Archaea	T	Roadblock LC7 family protein	-	-	-	ko:K06945,ko:K07131	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
SRR25158203_k127_3129341_13	1324957.K933_05358	1.948e-12	70.0	COG1534@1|root,arCOG01346@2157|Archaea,2XZWJ@28890|Euryarchaeota,23XQI@183963|Halobacteria	183963|Halobacteria	J	RNA-binding protein containing KH domain, possibly ribosomal protein	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
SRR25158203_k127_3129341_7	693661.Arcve_1760	1.314e-54	195.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,24658@183980|Archaeoglobi	183980|Archaeoglobi	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
SRR25158203_k127_3129341_12	351160.RCIX1046	3.422e-23	102.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
SRR25158203_k127_3129341_8	331113.SNE_A17000	3.695e-42	161.0	COG0215@1|root,COG0215@2|Bacteria,2JFNB@204428|Chlamydiae	204428|Chlamydiae	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
SRR25158203_k127_3132551_2	368408.Tpen_0658	7.325e-26	110.0	COG2100@1|root,arCOG00951@2157|Archaea,2XPKN@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06935	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
SRR25158203_k127_3132551_4	338969.Rfer_0855	9.738e-18	87.0	COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,2VX4U@28216|Betaproteobacteria,4AFQ6@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3132551_3	634497.HAH_1153	3.83e-20	99.0	COG3361@1|root,arCOG04579@2157|Archaea,2XV94@28890|Euryarchaeota,23UH6@183963|Halobacteria	183963|Halobacteria	S	Uncharacterized conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
SRR25158203_k127_3132551_1	1094980.Mpsy_2622	6.284e-137	442.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SRR25158203_k127_3132551_0	1499967.BAYZ01000025_gene287	0.0	1135.0	COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria	2|Bacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03694,ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
SRR25158203_k127_3135_0	192952.MM_3279	1.052e-205	649.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRR25158203_k127_3135_1	1027292.HMPREF9372_3725	8.254e-126	417.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4HBZR@91061|Bacilli,26GQA@186818|Planococcaceae	91061|Bacilli	H	Resistance to Hg(2 ) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0)	merA	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	HMA,Pyr_redox_2,Pyr_redox_dim
SRR25158203_k127_3135_2	869210.Marky_0299	2.257e-33	132.0	COG3370@1|root,COG3370@2|Bacteria,1WKRN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM DsrE DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
SRR25158203_k127_3135_3	411459.RUMOBE_02442	5.25e-06	50.0	COG3012@1|root,COG3012@2|Bacteria,1V72J@1239|Firmicutes,25F7K@186801|Clostridia	186801|Clostridia	S	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3,SEC-C
SRR25158203_k127_3142920_0	357808.RoseRS_2134	0.0	1164.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GAC0@200795|Chloroflexi,376BQ@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
SRR25158203_k127_3142920_15	523845.AQXV01000028_gene1044	3.851e-12	67.0	COG1598@1|root,arCOG02412@2157|Archaea,2Y1KV@28890|Euryarchaeota,23RSI@183939|Methanococci	183939|Methanococci	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3142920_11	1094980.Mpsy_2897	3.515e-24	107.0	arCOG05272@1|root,arCOG05272@2157|Archaea,2Y5FY@28890|Euryarchaeota,2NBD9@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3142920_16	1094980.Mpsy_1559	7.096e-07	59.0	arCOG02934@1|root,arCOG02934@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3142920_4	192952.MM_1007	1.438e-73	252.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
SRR25158203_k127_3142920_5	864051.BurJ1DRAFT_3878	1.797e-69	250.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria	1224|Proteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
SRR25158203_k127_3142920_13	1047013.AQSP01000144_gene918	1.014e-20	93.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
SRR25158203_k127_3142920_9	1122169.AREN01000023_gene1630	1.818e-31	129.0	COG0778@1|root,COG0778@2|Bacteria,1PGJY@1224|Proteobacteria,1S99H@1236|Gammaproteobacteria,1JE2K@118969|Legionellales	118969|Legionellales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRR25158203_k127_3142920_14	304371.MCP_0002	3.019e-18	93.0	COG3729@1|root,arCOG11115@2157|Archaea	2157|Archaea	S	general stress protein B in uncultured methanogenic archaeon (Q0W564)	-	-	-	-	-	-	-	-	-	-	-	-	KGG
SRR25158203_k127_3142920_1	192952.MM_1741	4.448e-157	506.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,2N97X@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
SRR25158203_k127_3142920_7	192952.MM_1740	1.377e-61	219.0	COG1648@1|root,arCOG01044@2157|Archaea,2XWMY@28890|Euryarchaeota,2N9U9@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM siroheme synthase	cysG	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
SRR25158203_k127_3142920_6	1094980.Mpsy_2493	5.085e-67	231.0	COG1522@1|root,arCOG01628@2157|Archaea,2XUFJ@28890|Euryarchaeota,2N9V6@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein AsnC Lrp family	-	-	-	ko:K22225	-	-	-	-	ko00000	-	-	-	HTH_AsnC-type
SRR25158203_k127_3142920_8	877455.Metbo_0586	6.583e-43	164.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,23P32@183925|Methanobacteria	183925|Methanobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
SRR25158203_k127_3142920_2	289376.THEYE_A1394	1.495e-133	434.0	COG1260@1|root,COG1260@2|Bacteria	2|Bacteria	I	inositol-3-phosphate synthase activity	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
SRR25158203_k127_3142920_3	56780.SYN_00522	1.167e-96	323.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,42MNY@68525|delta/epsilon subdivisions,2WJ6C@28221|Deltaproteobacteria,2MRDE@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	CobB/CobQ-like glutamine amidotransferase domain	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
SRR25158203_k127_3142920_12	1173022.Cri9333_4210	2.502e-21	98.0	2DMNB@1|root,32SNM@2|Bacteria,1G421@1117|Cyanobacteria,1HBEQ@1150|Oscillatoriales	1117|Cyanobacteria	S	RloB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	RloB
SRR25158203_k127_3142920_10	445972.ANACOL_02573	6.704e-26	109.0	COG1106@1|root,COG1106@2|Bacteria,1TSBY@1239|Firmicutes,249DS@186801|Clostridia,3WJY3@541000|Ruminococcaceae	186801|Clostridia	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
SRR25158203_k127_3148685_13	596330.HMPREF0628_0478	0.0005928	51.0	28KIX@1|root,2ZA44@2|Bacteria,1UYPD@1239|Firmicutes,24ATH@186801|Clostridia,22GKY@1570339|Peptoniphilaceae	186801|Clostridia	S	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	phaE	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
SRR25158203_k127_3148685_12	1120797.KB908261_gene156	6.702e-05	52.0	2BKX7@1|root,32FDQ@2|Bacteria,2H3D3@201174|Actinobacteria,23C81@1762|Mycobacteriaceae	201174|Actinobacteria	S	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	-	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
SRR25158203_k127_3148685_2	1410653.JHVC01000008_gene3146	8.178e-125	413.0	COG3243@1|root,COG3243@2|Bacteria,1V0SA@1239|Firmicutes,24D2G@186801|Clostridia,36RAI@31979|Clostridiaceae	186801|Clostridia	I	PHB de-polymerase C-terminus	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
SRR25158203_k127_3148685_5	1121468.AUBR01000063_gene984	2.011e-88	300.0	COG1028@1|root,COG1028@2|Bacteria,1TPIK@1239|Firmicutes,25073@186801|Clostridia,42HMP@68295|Thermoanaerobacterales	186801|Clostridia	IQ	KR domain	fabG2	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRR25158203_k127_3148685_1	1392487.JIAD01000001_gene1052	2.217e-158	509.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,25VH5@186806|Eubacteriaceae	186801|Clostridia	I	Belongs to the thiolase family	thlA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRR25158203_k127_3148685_6	187272.Mlg_0994	1.876e-76	265.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1WXR9@135613|Chromatiales	135613|Chromatiales	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
SRR25158203_k127_3148685_4	1121468.AUBR01000063_gene984	2.821e-98	327.0	COG1028@1|root,COG1028@2|Bacteria,1TPIK@1239|Firmicutes,25073@186801|Clostridia,42HMP@68295|Thermoanaerobacterales	186801|Clostridia	IQ	KR domain	fabG2	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRR25158203_k127_3148685_11	1227487.C474_11141	2.902e-05	50.0	COG0599@1|root,arCOG02148@2157|Archaea,2XYCN@28890|Euryarchaeota,23W7U@183963|Halobacteria	183963|Halobacteria	S	homolog of gamma-carboxymuconolactone decarboxylase subunit	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_3148685_3	1094980.Mpsy_0752	1.637e-107	355.0	COG1363@1|root,arCOG01518@2157|Archaea,2XT3M@28890|Euryarchaeota,2N94F@224756|Methanomicrobia	224756|Methanomicrobia	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
SRR25158203_k127_3148685_9	293826.Amet_0128	6.35e-14	79.0	2CCBH@1|root,341DK@2|Bacteria,1VWYC@1239|Firmicutes,24VB7@186801|Clostridia,36PWM@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3148685_7	693661.Arcve_0736	3.705e-19	88.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y6IM@28890|Euryarchaeota,247DB@183980|Archaeoglobi	183980|Archaeoglobi	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SRR25158203_k127_3148685_8	269797.Mbar_A3489	9.62e-17	80.0	COG3385@1|root,arCOG04496@2157|Archaea,2Y7GJ@28890|Euryarchaeota,2N9SD@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1
SRR25158203_k127_3148685_10	985665.HPL003_06165	2.775e-05	53.0	COG1474@1|root,COG1474@2|Bacteria,1TQBU@1239|Firmicutes,4HFJF@91061|Bacilli,2728M@186822|Paenibacillaceae	91061|Bacilli	LO	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3148685_0	1094980.Mpsy_0912	7.762e-180	573.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SRR25158203_k127_3167607_1	247490.KSU1_B0174	1.656e-56	201.0	COG1246@1|root,COG1246@2|Bacteria,2J092@203682|Planctomycetes	203682|Planctomycetes	E	Acetyltransferase (GNAT) domain	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7
SRR25158203_k127_3167607_0	1094980.Mpsy_1056	4.392e-209	657.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,2N963@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
SRR25158203_k127_3167607_2	118005.AWNK01000017_gene974	1.964e-55	201.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
SRR25158203_k127_3167607_3	351160.LRC537	3.019e-13	70.0	COG0463@1|root,arCOG00894@2157|Archaea,2XTEG@28890|Euryarchaeota,2N988@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
SRR25158203_k127_3178471_0	269797.Mbar_A0242	1.712e-79	275.0	COG1287@1|root,arCOG02043@2157|Archaea,2XU8G@28890|Euryarchaeota,2N921@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
SRR25158203_k127_3178471_1	192952.MM_1495	5.047e-70	245.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,2N9NJ@224756|Methanomicrobia	224756|Methanomicrobia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	iAF692.Mbar_A1332	PseudoU_synth_1
SRR25158203_k127_3178471_2	484770.UFO1_3678	3.079e-65	235.0	COG2227@1|root,COG2227@2|Bacteria,1UGIP@1239|Firmicutes	1239|Firmicutes	H	PFAM O-methyltransferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_2
SRR25158203_k127_3178471_3	1094980.Mpsy_1348	1.433e-49	183.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYAZ@28890|Euryarchaeota,2N9WV@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRR25158203_k127_3178471_4	456442.Mboo_1138	3.442e-38	151.0	COG3384@1|root,arCOG01730@2157|Archaea,2Y0BA@28890|Euryarchaeota,2NAWC@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
SRR25158203_k127_3178471_5	304371.MCP_0975	1.03e-35	138.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y72M@28890|Euryarchaeota,2NB71@224756|Methanomicrobia	224756|Methanomicrobia	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SRR25158203_k127_3178471_6	386456.JQKN01000004_gene202	3.203e-27	111.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0FK@28890|Euryarchaeota	28890|Euryarchaeota	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
SRR25158203_k127_3197300_2	1242864.D187_003538	1.557e-29	132.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,42PDK@68525|delta/epsilon subdivisions,2WJKJ@28221|Deltaproteobacteria,2YTX7@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
SRR25158203_k127_3197300_1	316274.Haur_4172	1.946e-51	202.0	COG2719@1|root,COG2719@2|Bacteria,2G83B@200795|Chloroflexi,3758M@32061|Chloroflexia	32061|Chloroflexia	S	SpoVR like protein	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
SRR25158203_k127_3197300_0	765913.ThidrDRAFT_0627	8.5e-67	237.0	COG0500@1|root,COG2226@2|Bacteria,1N3VV@1224|Proteobacteria,1SCTZ@1236|Gammaproteobacteria,1WZXH@135613|Chromatiales	135613|Chromatiales	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3200026_0	192952.MM_2147	2.85e-236	739.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,2N9AJ@224756|Methanomicrobia	224756|Methanomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
SRR25158203_k127_3200026_10	192952.MM_2146	3.419e-48	177.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,2N9U7@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
SRR25158203_k127_3200026_7	192952.MM_2145	4.241e-54	193.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,2N9JA@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM ribosomal protein L30P	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
SRR25158203_k127_3200026_1	1094980.Mpsy_1126	7.065e-91	304.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,2N954@224756|Methanomicrobia	224756|Methanomicrobia	J	With S4 and S12 plays an important role in translational accuracy	rps5	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
SRR25158203_k127_3200026_9	456442.Mboo_0551	7.502e-49	180.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2N9SW@224756|Methanomicrobia	224756|Methanomicrobia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
SRR25158203_k127_3200026_8	192952.MM_2142	6.602e-52	187.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,2N9QQ@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
SRR25158203_k127_3200026_11	1227488.C477_12950	1.248e-42	166.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,23SSD@183963|Halobacteria	183963|Halobacteria	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
SRR25158203_k127_3200026_3	192952.MM_2140	1.651e-65	228.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,2N9KP@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
SRR25158203_k127_3200026_6	351160.RCIX2561	4.161e-54	192.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2N9Q6@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
SRR25158203_k127_3200026_14	1041930.Mtc_1337	3.365e-21	93.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y04R@28890|Euryarchaeota,2NA3T@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
SRR25158203_k127_3200026_4	1094980.Mpsy_1133	5.519e-63	220.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,2N9KJ@224756|Methanomicrobia	224756|Methanomicrobia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
SRR25158203_k127_3200026_2	269797.Mbar_A0098	6.221e-75	258.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,2N9HR@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,RS4NT,Ribosomal_S4e,S4
SRR25158203_k127_3200026_12	269797.Mbar_A0099	5.3e-40	151.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,2N9XR@224756|Methanomicrobia	224756|Methanomicrobia	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
SRR25158203_k127_3200026_5	192952.MM_2134	1.05e-57	203.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,2N9SH@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SRR25158203_k127_3200026_13	573063.Metin_0628	1.118e-21	98.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23R70@183939|Methanococci	183939|Methanococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	GO:0000172,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
SRR25158203_k127_3200026_15	1094980.Mpsy_1139	5.429e-21	93.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,2NA4R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SRR25158203_k127_3200026_16	1094980.Mpsy_1140	2.032e-05	48.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,2N95N@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SRR25158203_k127_3201761_1	867903.ThesuDRAFT_01405	6.979e-15	80.0	298S5@1|root,313VY@2|Bacteria,1U9KD@1239|Firmicutes,25702@186801|Clostridia	186801|Clostridia	S	Protein of unknown function with PCYCGC motif	-	-	-	-	-	-	-	-	-	-	-	-	PCYCGC
SRR25158203_k127_3201761_0	1104324.P186_1785	6.041e-19	87.0	COG3350@1|root,arCOG04507@2157|Archaea,2XR9V@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
SRR25158203_k127_3201761_2	665571.STHERM_c14960	1.879e-09	64.0	28WAT@1|root,2ZIB9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3201761_3	565033.GACE_0129	6.128e-05	52.0	arCOG12292@1|root,arCOG12292@2157|Archaea,2Y4SX@28890|Euryarchaeota,247B1@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3206233_0	273116.14325755	1.845e-98	335.0	COG0582@1|root,arCOG01241@2157|Archaea,2XWM9@28890|Euryarchaeota	28890|Euryarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3206233_1	604354.TSIB_0264	2.118e-76	268.0	COG2441@1|root,arCOG04329@2157|Archaea,2XW6E@28890|Euryarchaeota,243JG@183968|Thermococci	183968|Thermococci	C	Protein of unknown function (DUF1464)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1464
SRR25158203_k127_3253499_8	1280954.HPO_03774	0.0008041	47.0	COG0745@1|root,COG2199@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Response_reg
SRR25158203_k127_3253499_4	635013.TherJR_2300	3.807e-61	215.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K02660,ko:K03406,ko:K03776,ko:K11525	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	GAF,HAMP,MCPsignal,PAS_3,PilZ,dCache_1
SRR25158203_k127_3253499_2	545243.BAEV01000012_gene993	7.114e-152	503.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,36DKP@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	cooS1	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
SRR25158203_k127_3253499_6	192952.MM_0066	1.642e-23	116.0	COG3291@1|root,arCOG02550@1|root,arCOG02546@2157|Archaea,arCOG02550@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CARDB,Cellulase,NosD,PKD,PQQ_3,Pkinase,VWA
SRR25158203_k127_3253499_7	997346.HMPREF9374_3172	2.499e-19	93.0	2E61F@1|root,330QP@2|Bacteria,1VASH@1239|Firmicutes,4HKBT@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF4064)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4064
SRR25158203_k127_3253499_5	589924.Ferp_1813	7.748e-39	153.0	arCOG09418@1|root,arCOG09418@2157|Archaea,2XZ3S@28890|Euryarchaeota,246F9@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3253499_0	1094980.Mpsy_0817	7.92e-207	657.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,2N968@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
SRR25158203_k127_3253499_1	1123242.JH636434_gene3359	4.083e-201	644.0	COG1166@1|root,COG1166@2|Bacteria,2IX6P@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
SRR25158203_k127_3253499_3	1094980.Mpsy_2079	8.357e-65	226.0	COG1772@1|root,arCOG04364@2157|Archaea,2XXJ6@28890|Euryarchaeota,2N9MC@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF531)	-	-	-	ko:K09725	-	-	-	-	ko00000	-	-	-	DUF531
SRR25158203_k127_3267043_1	1121468.AUBR01000063_gene984	4.38e-96	320.0	COG1028@1|root,COG1028@2|Bacteria,1TPIK@1239|Firmicutes,25073@186801|Clostridia,42HMP@68295|Thermoanaerobacterales	186801|Clostridia	IQ	KR domain	fabG2	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRR25158203_k127_3267043_2	1379698.RBG1_1C00001G1531	1.413e-93	318.0	COG0123@1|root,COG0123@2|Bacteria,2NPB6@2323|unclassified Bacteria	2|Bacteria	BQ	Histone deacetylase domain	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SRR25158203_k127_3267043_3	1089553.Tph_c01470	1.825e-24	107.0	COG3576@1|root,COG3576@2|Bacteria,1VCPZ@1239|Firmicutes,24NTP@186801|Clostridia,42IK7@68295|Thermoanaerobacterales	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
SRR25158203_k127_3267043_0	351160.RCIX1018	9.391e-123	401.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2N941@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
SRR25158203_k127_3270731_2	1094980.Mpsy_0958	3.206e-40	151.0	COG1348@1|root,arCOG00590@2157|Archaea,2XUNI@28890|Euryarchaeota,2N9FB@224756|Methanomicrobia	224756|Methanomicrobia	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	nifH-1	-	1.18.6.1,6.3.3.7	ko:K02588,ko:K21610	ko00625,ko00860,ko00910,ko01100,ko01120,map00625,map00860,map00910,map01100,map01120	M00175,M00836	R05185,R05496,R11628	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
SRR25158203_k127_3270731_0	1094980.Mpsy_0957	2.002e-191	608.0	COG1797@1|root,arCOG00106@2157|Archaea,2XTIE@28890|Euryarchaeota,2N96K@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source	cbiA-1	-	6.3.5.12	ko:K22012	ko00860,map00860	M00836	R11627	-	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
SRR25158203_k127_3270731_1	1094980.Mpsy_1785	7.172e-110	366.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,2N945@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM elongation factor Tu domain 2	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
SRR25158203_k127_327282_2	269797.Mbar_A1073	8.244e-162	518.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,2N94X@224756|Methanomicrobia	224756|Methanomicrobia	J	TGS domain protein	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
SRR25158203_k127_327282_0	247490.KSU1_C1370	2.061e-276	861.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SRR25158203_k127_327282_7	304371.MCP_2020	1.616e-39	154.0	COG0576@1|root,arCOG04772@2157|Archaea,2XUCA@28890|Euryarchaeota,2NA0X@224756|Methanomicrobia	224756|Methanomicrobia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
SRR25158203_k127_327282_1	593750.Metfor_2914	9.654e-185	592.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR25158203_k127_327282_6	485916.Dtox_0855	1.39e-59	214.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	MA20_02340	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
SRR25158203_k127_327282_3	1469607.KK073768_gene2259	1.715e-91	308.0	COG4106@1|root,COG4106@2|Bacteria,1G3BF@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
SRR25158203_k127_327282_4	351160.RCIX2132	7.064e-90	302.0	COG0390@1|root,arCOG04953@2157|Archaea,2XVRH@28890|Euryarchaeota,2NA3H@224756|Methanomicrobia	224756|Methanomicrobia	P	Uncharacterised protein family (UPF0014)	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
SRR25158203_k127_327282_5	351160.RCIX2133	1.107e-76	264.0	COG3839@1|root,arCOG00175@2157|Archaea,2XW46@28890|Euryarchaeota	28890|Euryarchaeota	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02068	-	M00211	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
SRR25158203_k127_3274020_5	1238425.J07HQW2_01231	1.941e-41	165.0	COG0582@1|root,arCOG01241@2157|Archaea	2157|Archaea	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integr_3,Phage_integrase
SRR25158203_k127_3274020_2	1094980.Mpsy_2662	1.442e-67	235.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,2N9KM@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
SRR25158203_k127_3274020_4	1094980.Mpsy_3178	3.255e-61	218.0	COG0755@1|root,arCOG00267@2157|Archaea,2XXKZ@28890|Euryarchaeota,2NA4P@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
SRR25158203_k127_3274020_0	1094980.Mpsy_3179	1.191e-77	268.0	COG2386@1|root,arCOG01328@2157|Archaea,2XTAS@28890|Euryarchaeota,2NAJD@224756|Methanomicrobia	224756|Methanomicrobia	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
SRR25158203_k127_3274020_3	192952.MM_2398	2.227e-67	237.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUWP@28890|Euryarchaeota,2NAQN@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
SRR25158203_k127_3274020_1	1094980.Mpsy_1395	6.305e-69	241.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,2N9XX@224756|Methanomicrobia	224756|Methanomicrobia	N	Peptidase A24A, prepilin type IV	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
SRR25158203_k127_3291161_0	1459636.NTE_00007	1.694e-101	349.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
SRR25158203_k127_3291161_4	1227495.C487_17360	4.379e-10	64.0	arCOG07300@1|root,arCOG07300@2157|Archaea,2XXYB@28890|Euryarchaeota,23WG9@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3291161_2	269797.Mbar_A2076	2.054e-16	81.0	COG3432@1|root,arCOG01055@2157|Archaea,2Y23V@28890|Euryarchaeota,2NBDP@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR25158203_k127_3291161_1	693661.Arcve_0168	4.953e-39	157.0	COG0382@1|root,arCOG00476@2157|Archaea,2XZI7@28890|Euryarchaeota,246CK@183980|Archaeoglobi	183980|Archaeoglobi	H	UbiA prenyltransferase family	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SRR25158203_k127_3291161_3	693661.Arcve_0169	2.788e-13	75.0	arCOG10223@1|root,arCOG10223@2157|Archaea,2XXPY@28890|Euryarchaeota,2468J@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3329769_1	1128398.Curi_c21650	3.601e-99	340.0	COG2710@1|root,COG2710@2|Bacteria,1TPJX@1239|Firmicutes,2498K@186801|Clostridia,269SD@186813|unclassified Clostridiales	186801|Clostridia	C	Nitrogenase component 1 type Oxidoreductase	-	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
SRR25158203_k127_3329769_4	1128398.Curi_c21640	1.013e-68	252.0	COG2710@1|root,COG2710@2|Bacteria,1U2YW@1239|Firmicutes,2588S@186801|Clostridia,26BWQ@186813|unclassified Clostridiales	186801|Clostridia	C	Nitrogenase component 1 type Oxidoreductase	-	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
SRR25158203_k127_3329769_0	456442.Mboo_2008	1.152e-126	410.0	COG1348@1|root,arCOG00590@2157|Archaea,2XUNI@28890|Euryarchaeota,2N9FB@224756|Methanomicrobia	224756|Methanomicrobia	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	nifH-1	-	1.18.6.1,6.3.3.7	ko:K02588,ko:K21610	ko00625,ko00860,ko00910,ko01100,ko01120,map00625,map00860,map00910,map01100,map01120	M00175,M00836	R05185,R05496,R11628	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
SRR25158203_k127_3329769_11	1150600.ADIARSV_3390	4.224e-18	96.0	COG2271@1|root,COG2271@2|Bacteria,4NFKX@976|Bacteroidetes,1IQUV@117747|Sphingobacteriia	976|Bacteroidetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRR25158203_k127_3329769_9	86416.Clopa_0937	9.736e-50	190.0	COG0715@1|root,COG0715@2|Bacteria,1UYGB@1239|Firmicutes	1239|Firmicutes	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
SRR25158203_k127_3329769_6	1122947.FR7_4418	2.624e-65	231.0	COG0600@1|root,COG0600@2|Bacteria,1TQVZ@1239|Firmicutes,4H5AI@909932|Negativicutes	909932|Negativicutes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SRR25158203_k127_3329769_7	1122947.FR7_4418	9.949e-65	236.0	COG0600@1|root,COG0600@2|Bacteria,1TQVZ@1239|Firmicutes,4H5AI@909932|Negativicutes	909932|Negativicutes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SRR25158203_k127_3329769_8	1123371.ATXH01000045_gene1866	1.677e-60	213.0	COG1751@1|root,COG1751@2|Bacteria,2GIEF@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
SRR25158203_k127_3329769_5	521011.Mpal_1125	6.02e-66	234.0	COG0500@1|root,arCOG01783@2157|Archaea,2Y0HZ@28890|Euryarchaeota,2NABS@224756|Methanomicrobia	2157|Archaea	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR25158203_k127_3329769_10	545243.BAEV01000008_gene1220	1.6e-33	144.0	COG0715@1|root,COG0715@2|Bacteria,1V8U3@1239|Firmicutes,24BTK@186801|Clostridia,36FUC@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
SRR25158203_k127_3329769_3	1122947.FR7_4418	1.949e-82	282.0	COG0600@1|root,COG0600@2|Bacteria,1TQVZ@1239|Firmicutes,4H5AI@909932|Negativicutes	909932|Negativicutes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SRR25158203_k127_3329769_2	521011.Mpal_1132	3.13e-90	301.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SRR25158203_k127_334287_3	638302.HMPREF0908_1019	0.000838	46.0	COG0492@1|root,COG3634@1|root,COG0492@2|Bacteria,COG3634@2|Bacteria,1TNZS@1239|Firmicutes,4H1Z5@909932|Negativicutes	909932|Negativicutes	C	Thioredoxin-disulfide reductase	trxB2	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
SRR25158203_k127_334287_1	269797.Mbar_A2888	7.677e-56	198.0	arCOG03197@1|root,arCOG03197@2157|Archaea,2XZKC@28890|Euryarchaeota,2N9ZV@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_334287_2	269797.Mbar_A2887	9.26e-10	60.0	arCOG04838@1|root,arCOG04838@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_334287_0	1094980.Mpsy_1449	2.786e-143	466.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
SRR25158203_k127_3347793_11	529709.PYCH_01970	3.06e-15	80.0	arCOG04797@1|root,arCOG04797@2157|Archaea,2XZMY@28890|Euryarchaeota,24531@183968|Thermococci	183968|Thermococci	S	retrograde transport, endosome to Golgi	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3347793_3	485916.Dtox_1645	1.644e-122	403.0	COG1060@1|root,COG1060@2|Bacteria,1TRHG@1239|Firmicutes,247Z2@186801|Clostridia,2609W@186807|Peptococcaceae	186801|Clostridia	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
SRR25158203_k127_3347793_2	192952.MM_0698	1.14e-165	535.0	COG0294@1|root,arCOG01978@2157|Archaea,2XTEW@28890|Euryarchaeota,2N967@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	-	-	-	-	-	-	-	-	-	-	DUF4346,Pterin_bind
SRR25158203_k127_3347793_9	192952.MM_2731	6.972e-52	192.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota,2N9VP@224756|Methanomicrobia	224756|Methanomicrobia	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
SRR25158203_k127_3347793_0	1094980.Mpsy_0575	2.197e-221	692.0	COG1061@1|root,arCOG00874@2157|Archaea,2XTYQ@28890|Euryarchaeota,2N95D@224756|Methanomicrobia	224756|Methanomicrobia	L	helicase superfamily c-terminal domain	rad25	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,ResIII
SRR25158203_k127_3347793_1	1094980.Mpsy_0576	3.098e-194	617.0	COG3372@1|root,arCOG04356@2157|Archaea,2XSTX@28890|Euryarchaeota,2N95G@224756|Methanomicrobia	224756|Methanomicrobia	L	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
SRR25158203_k127_3347793_13	439235.Dalk_5084	9.796e-06	59.0	COG2041@1|root,COG2041@2|Bacteria,1NS6T@1224|Proteobacteria,42YA7@68525|delta/epsilon subdivisions,2WTM5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3347793_5	179408.Osc7112_0245	5.737e-57	225.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1G463@1117|Cyanobacteria,1H97Y@1150|Oscillatoriales	1117|Cyanobacteria	MQ	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,SdrD_B
SRR25158203_k127_3347793_7	1123371.ATXH01000007_gene525	2.38e-56	206.0	COG4089@1|root,COG4089@2|Bacteria,2GI8X@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
SRR25158203_k127_3347793_6	868131.MSWAN_0889	8.643e-57	200.0	COG2193@1|root,arCOG01094@2157|Archaea,2Y3W0@28890|Euryarchaeota	28890|Euryarchaeota	P	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SRR25158203_k127_3347793_10	269797.Mbar_A2017	2.904e-49	179.0	COG1238@1|root,arCOG03118@2157|Archaea	2157|Archaea	I	SNARE associated Golgi protein	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
SRR25158203_k127_3347793_8	1041930.Mtc_2371	1.423e-54	198.0	COG1624@1|root,arCOG04453@2157|Archaea	2157|Archaea	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
SRR25158203_k127_3347793_4	1041930.Mtc_1408	6.314e-99	329.0	COG0253@1|root,arCOG02255@2157|Archaea,2XUYX@28890|Euryarchaeota,2NAG6@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
SRR25158203_k127_3347793_12	269799.Gmet_1924	1.593e-10	71.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1
SRR25158203_k127_336554_0	69014.TK0182	6.101e-90	301.0	COG2013@1|root,arCOG01907@2157|Archaea,2XW0I@28890|Euryarchaeota,243BV@183968|Thermococci	183968|Thermococci	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
SRR25158203_k127_336554_1	269797.Mbar_A2035	1.816e-55	199.0	COG0622@1|root,arCOG01141@2157|Archaea,2XWQ0@28890|Euryarchaeota,2N9SN@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SRR25158203_k127_337632_10	335543.Sfum_4005	2.14e-05	55.0	COG4870@1|root,COG4870@2|Bacteria,1RJ0M@1224|Proteobacteria,42V4Z@68525|delta/epsilon subdivisions,2WRZX@28221|Deltaproteobacteria,2MSFX@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
SRR25158203_k127_337632_9	693661.Arcve_0033	1.796e-09	62.0	arCOG02104@1|root,arCOG02104@2157|Archaea,2XZI1@28890|Euryarchaeota,246CQ@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_337632_3	192952.MM_1914	3.283e-101	337.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SRR25158203_k127_337632_5	351160.LRC265	7.572e-67	241.0	COG3390@1|root,arCOG02258@2157|Archaea,2XT3R@28890|Euryarchaeota,2N9P2@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
SRR25158203_k127_337632_4	269797.Mbar_A1433	7.142e-89	308.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,2N9QC@224756|Methanomicrobia	224756|Methanomicrobia	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
SRR25158203_k127_337632_2	269797.Mbar_A2036	1.664e-104	345.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,2N9I6@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein, Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
SRR25158203_k127_337632_8	192952.MM_0288	1.172e-51	187.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,2N9RU@224756|Methanomicrobia	224756|Methanomicrobia	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
SRR25158203_k127_337632_7	192952.MM_1823	1.146e-54	196.0	COG2426@1|root,arCOG01330@2157|Archaea,2XZ2Y@28890|Euryarchaeota,2NAQX@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
SRR25158203_k127_337632_1	1094980.Mpsy_1211	4.928e-140	451.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,2N91S@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rad17,Rep_fac_C
SRR25158203_k127_337632_0	192952.MM_0515	8.141e-168	534.0	COG2710@1|root,arCOG04888@2157|Archaea,2XUYC@28890|Euryarchaeota,2N90I@224756|Methanomicrobia	224756|Methanomicrobia	C	Methanogenesis marker 13 metalloprotein	-	-	6.3.3.7	ko:K21611	ko00860,ko01120,map00860,map01120	M00836	R11628	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
SRR25158203_k127_337632_6	351160.RCIX2002	1.591e-58	206.0	COG1348@1|root,arCOG00590@2157|Archaea,2XUNI@28890|Euryarchaeota,2N9FB@224756|Methanomicrobia	224756|Methanomicrobia	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	nifH-1	-	1.18.6.1,6.3.3.7	ko:K02588,ko:K21610	ko00625,ko00860,ko00910,ko01100,ko01120,map00625,map00860,map00910,map01100,map01120	M00175,M00836	R05185,R05496,R11628	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
SRR25158203_k127_3379765_13	647113.Metok_1361	2.913e-18	97.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,23R54@183939|Methanococci	183939|Methanococci	S	SMART Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
SRR25158203_k127_3379765_3	1094980.Mpsy_0255	1.267e-87	297.0	COG0467@1|root,arCOG01175@2157|Archaea,2XUNH@28890|Euryarchaeota,2NAZW@224756|Methanomicrobia	224756|Methanomicrobia	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SRR25158203_k127_3379765_9	316067.Geob_1358	1.785e-41	160.0	COG4900@1|root,COG4900@2|Bacteria,1NQAA@1224|Proteobacteria,42X8V@68525|delta/epsilon subdivisions,2WT0I@28221|Deltaproteobacteria,43V8W@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3379765_1	192952.MM_0485	2.828e-164	527.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,2N98M@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
SRR25158203_k127_3379765_2	269797.Mbar_A0622	6.425e-100	333.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,2N9EW@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM TatD-related deoxyribonuclease	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
SRR25158203_k127_3379765_4	1041930.Mtc_0357	3.642e-87	291.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,2N9N0@224756|Methanomicrobia	224756|Methanomicrobia	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbpE	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
SRR25158203_k127_3379765_5	1094980.Mpsy_2722	1.326e-84	286.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,2N9HN@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
SRR25158203_k127_3379765_11	192952.MM_2617	9.319e-33	131.0	COG1325@1|root,arCOG01042@2157|Archaea,2Y01Q@28890|Euryarchaeota,2NA08@224756|Methanomicrobia	224756|Methanomicrobia	J	RNA binding	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
SRR25158203_k127_3379765_7	1094980.Mpsy_2316	9.389e-79	278.0	COG0582@1|root,arCOG01242@2157|Archaea,2Y83U@28890|Euryarchaeota,2NAAN@224756|Methanomicrobia	224756|Methanomicrobia	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
SRR25158203_k127_3379765_16	387631.Asulf_01460	7.264e-07	58.0	arCOG02416@1|root,arCOG02416@2157|Archaea,2Y01H@28890|Euryarchaeota,247AH@183980|Archaeoglobi	183980|Archaeoglobi	N	Pfam:DUF1628	-	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
SRR25158203_k127_3379765_15	589924.Ferp_1554	8.139e-13	75.0	arCOG02416@1|root,arCOG02416@2157|Archaea,2Y01H@28890|Euryarchaeota,247AH@183980|Archaeoglobi	183980|Archaeoglobi	N	Pfam:DUF1628	-	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
SRR25158203_k127_3379765_12	1094980.Mpsy_2427	6.816e-19	87.0	arCOG06141@1|root,arCOG06141@2157|Archaea,2Y28R@28890|Euryarchaeota	28890|Euryarchaeota	S	Family of unknown function (DUF5371)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5371
SRR25158203_k127_3379765_14	693661.Arcve_0404	1.414e-13	73.0	COG1753@1|root,arCOG02681@2157|Archaea	2157|Archaea	S	Possibly the antitoxin component of a	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
SRR25158203_k127_3379765_10	589924.Ferp_1030	3.189e-36	142.0	COG1487@1|root,arCOG02219@2157|Archaea,2XZ5W@28890|Euryarchaeota,2473H@183980|Archaeoglobi	183980|Archaeoglobi	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
SRR25158203_k127_3379765_0	1094980.Mpsy_2827	9.432e-172	547.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N93E@224756|Methanomicrobia	224756|Methanomicrobia	M	transferase hexapeptide repeat containing protein	rfbM	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1937	Hexapep,NTP_transferase
SRR25158203_k127_3379765_6	1094980.Mpsy_0045	1.053e-83	283.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2N9IQ@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SRR25158203_k127_3379765_8	269797.Mbar_A1593	6.369e-42	158.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,2N9E6@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
SRR25158203_k127_3393599_9	743722.Sph21_1786	0.0003276	44.0	COG1215@1|root,COG1215@2|Bacteria,4PKM6@976|Bacteroidetes,1IT9V@117747|Sphingobacteriia	976|Bacteroidetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR25158203_k127_3393599_5	565033.GACE_0493	4.703e-68	239.0	COG0463@1|root,arCOG00895@2157|Archaea,2Y7SU@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR25158203_k127_3393599_4	192952.MM_0235	3.674e-77	273.0	arCOG05201@1|root,arCOG05201@2157|Archaea,2Y5MT@28890|Euryarchaeota,2NBBE@224756|Methanomicrobia	224756|Methanomicrobia	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3393599_0	323259.Mhun_0558	6.624e-210	660.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,2N98B@224756|Methanomicrobia	224756|Methanomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRR25158203_k127_3393599_2	1094980.Mpsy_0826	2.458e-166	532.0	COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,2N97U@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
SRR25158203_k127_3393599_7	269797.Mbar_A0831	1.576e-48	182.0	COG3291@1|root,arCOG03396@2157|Archaea	2157|Archaea	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
SRR25158203_k127_3393599_1	1041930.Mtc_1353	1.574e-175	554.0	COG0473@1|root,arCOG01163@2157|Archaea,2Y7K3@28890|Euryarchaeota,2N9DI@224756|Methanomicrobia	224756|Methanomicrobia	C	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
SRR25158203_k127_3393599_8	351160.RCIX71	5.086e-18	87.0	arCOG06692@1|root,arCOG06692@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3393599_6	273075.Ta0474	1.373e-59	208.0	COG1943@1|root,arCOG02759@2157|Archaea,2XWPT@28890|Euryarchaeota	28890|Euryarchaeota	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
SRR25158203_k127_3393599_3	1158345.JNLL01000002_gene2083	3.213e-93	320.0	COG0675@1|root,COG0675@2|Bacteria,2G4K0@200783|Aquificae	200783|Aquificae	L	COGs COG0675 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
SRR25158203_k127_3411444_5	935836.JAEL01000003_gene358	1.133e-20	95.0	COG1199@1|root,COG1199@2|Bacteria,1URXJ@1239|Firmicutes,4HF1N@91061|Bacilli,1ZG9U@1386|Bacillus	91061|Bacilli	L	HELICc2	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_2,ResIII
SRR25158203_k127_3411444_3	1220534.B655_1744	5.598e-45	169.0	COG2029@1|root,arCOG04875@2157|Archaea,2XV8B@28890|Euryarchaeota,23P0T@183925|Methanobacteria	183925|Methanobacteria	S	Domain of unknown function (DUF366)	-	-	-	ko:K09139	-	-	-	-	ko00000	-	-	-	DUF366
SRR25158203_k127_3411444_6	1094980.Mpsy_2446	2.488e-08	61.0	COG2034@1|root,arCOG02717@2157|Archaea,2Y6XS@28890|Euryarchaeota,2NBEI@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF131	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
SRR25158203_k127_3411444_7	693661.Arcve_0338	1.044e-06	56.0	COG2034@1|root,arCOG02717@2157|Archaea,2Y1TM@28890|Euryarchaeota,246IB@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function DUF131	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
SRR25158203_k127_3411444_2	1094980.Mpsy_0401	1.694e-46	179.0	arCOG04389@1|root,arCOG04389@2157|Archaea,2Y3UI@28890|Euryarchaeota,2NAW0@224756|Methanomicrobia	224756|Methanomicrobia	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3411444_4	1158338.JNLJ01000005_gene1590	1.57e-36	152.0	COG1373@1|root,COG1373@2|Bacteria,2G4ED@200783|Aquificae	200783|Aquificae	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
SRR25158203_k127_3411444_1	1094980.Mpsy_2796	6.406e-59	209.0	COG0286@1|root,arCOG02632@2157|Archaea,2XUMY@28890|Euryarchaeota,2NAGJ@224756|Methanomicrobia	28890|Euryarchaeota	V	HsdM N-terminal domain	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
SRR25158203_k127_3411444_0	933262.AXAM01000049_gene3260	7.648e-85	287.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,42RB7@68525|delta/epsilon subdivisions,2WN5V@28221|Deltaproteobacteria,2MJQK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	RadC-like JAB domain	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
SRR25158203_k127_341702_3	456442.Mboo_1980	8.209e-30	124.0	COG4742@1|root,arCOG04362@2157|Archaea,2XYCM@28890|Euryarchaeota,2N9SJ@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function (DUF1724)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1724
SRR25158203_k127_341702_2	589924.Ferp_2024	1.638e-57	213.0	COG2043@1|root,arCOG02289@2157|Archaea,2XXQ0@28890|Euryarchaeota,2468E@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
SRR25158203_k127_341702_0	589924.Ferp_2023	2.674e-166	531.0	COG1103@1|root,arCOG00091@2157|Archaea,2XU3S@28890|Euryarchaeota,24619@183980|Archaeoglobi	183980|Archaeoglobi	J	Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys))	-	-	2.5.1.73	ko:K06868	ko00970,map00970	-	R08577	RC02948	ko00000,ko00001,ko01000,ko03016	-	-	-	SepSecS
SRR25158203_k127_341702_1	909663.KI867150_gene337	4.228e-97	336.0	COG0823@1|root,COG0823@2|Bacteria,1Q2D4@1224|Proteobacteria,437ZF@68525|delta/epsilon subdivisions,2X39G@28221|Deltaproteobacteria,2MSI3@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_342146_5	192952.MM_0456	4.009e-67	235.0	COG0561@1|root,arCOG01213@2157|Archaea,2XX94@28890|Euryarchaeota,2N9JY@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the dephosphorylation of 2-phosphoglycolate	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
SRR25158203_k127_342146_0	192952.MM_0457	9.965e-164	520.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2N980@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
SRR25158203_k127_342146_1	1094980.Mpsy_1791	3.964e-121	399.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
SRR25158203_k127_342146_4	868131.MSWAN_0340	4.112e-80	269.0	COG3832@1|root,arCOG05261@2157|Archaea,2XYEH@28890|Euryarchaeota	28890|Euryarchaeota	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SRR25158203_k127_342146_6	386456.JQKN01000001_gene2092	2.429e-61	215.0	COG3832@1|root,arCOG05261@2157|Archaea,2XYEH@28890|Euryarchaeota	28890|Euryarchaeota	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SRR25158203_k127_342146_7	880070.Cycma_4779	6.648e-54	192.0	COG2764@1|root,COG2764@2|Bacteria,4NQD7@976|Bacteroidetes,47QQP@768503|Cytophagia	976|Bacteroidetes	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
SRR25158203_k127_342146_2	293826.Amet_1912	9.618e-120	392.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,24BVW@186801|Clostridia,36GH5@31979|Clostridiaceae	186801|Clostridia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
SRR25158203_k127_342146_3	1459636.NTE_02613	2.753e-91	304.0	COG0262@1|root,arCOG01490@2157|Archaea	2157|Archaea	H	Belongs to the dihydrofolate reductase family	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
SRR25158203_k127_342146_8	159087.Daro_3438	4.326e-46	169.0	COG3324@1|root,COG3324@2|Bacteria,1N1P5@1224|Proteobacteria,2W3PV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
SRR25158203_k127_3422539_0	1094980.Mpsy_2893	2.604e-211	661.0	COG1614@1|root,arCOG04360@2157|Archaea,2XU0D@28890|Euryarchaeota,2N95I@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex)	cdhC	-	-	ko:K00193	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00357,M00422	R09096,R10219	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
SRR25158203_k127_3422539_2	1094980.Mpsy_2894	3.627e-44	168.0	COG1880@1|root,arCOG04408@2157|Archaea,2XWPE@28890|Euryarchaeota,2NA4Z@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear	cdhB	-	-	ko:K00195	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002	-	-	-	CO_dh
SRR25158203_k127_3422539_1	1094980.Mpsy_2895	5.075e-114	372.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota,2N9CY@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	-	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_7,Fer4_9,Prismane
SRR25158203_k127_3442263_0	269797.Mbar_A2972	1.372e-71	243.0	arCOG04915@1|root,arCOG04915@2157|Archaea,2Y3CG@28890|Euryarchaeota,2NAQQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3442263_3	269797.Mbar_A3382	5.965e-09	65.0	COG2834@1|root,arCOG02470@2157|Archaea,2XWT9@28890|Euryarchaeota,2NB4U@224756|Methanomicrobia	224756|Methanomicrobia	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
SRR25158203_k127_3442263_2	269797.Mbar_A1819	1.132e-29	126.0	COG2512@1|root,arCOG00386@2157|Archaea	2157|Archaea	S	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR,MarR_2,TrmB
SRR25158203_k127_3442263_1	269797.Mbar_A1818	1.092e-37	153.0	arCOG04955@1|root,arCOG04955@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3444174_3	224325.AF_1797	6.504e-06	51.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2467S@183980|Archaeoglobi	183980|Archaeoglobi	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SRR25158203_k127_3444174_0	880073.Calab_1228	2.449e-63	225.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
SRR25158203_k127_3444174_1	331113.SNE_A10660	1.995e-54	207.0	COG1926@1|root,COG1926@2|Bacteria,2JG9P@204428|Chlamydiae	204428|Chlamydiae	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
SRR25158203_k127_3444174_2	269797.Mbar_A0490	2.55e-19	90.0	arCOG08232@1|root,arCOG08232@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
SRR25158203_k127_34500_1	565033.GACE_2151	1.411e-35	142.0	COG2801@1|root,arCOG02125@2157|Archaea,2Y0JU@28890|Euryarchaeota,246MS@183980|Archaeoglobi	28890|Euryarchaeota	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
SRR25158203_k127_34500_2	1449126.JQKL01000014_gene2990	2.468e-20	94.0	COG0705@1|root,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,247PT@186801|Clostridia	186801|Clostridia	S	PFAM Rhomboid family	GlpG	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SRR25158203_k127_34500_0	521011.Mpal_1317	2.158e-51	191.0	COG1624@1|root,COG3291@1|root,arCOG02510@2157|Archaea,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota,2N9M8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
SRR25158203_k127_3467897_0	1094980.Mpsy_0373	2.312e-81	278.0	COG4962@1|root,arCOG01817@2157|Archaea,2Y33P@28890|Euryarchaeota,2NAJC@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRR25158203_k127_3467897_2	456442.Mboo_2404	4.342e-44	171.0	COG2064@1|root,arCOG01808@2157|Archaea,2Y6XC@28890|Euryarchaeota,2NAII@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SRR25158203_k127_3467897_1	679926.Mpet_2639	1.845e-56	209.0	COG2064@1|root,arCOG02981@1|root,arCOG01808@2157|Archaea,arCOG02981@2157|Archaea,2Y2N6@28890|Euryarchaeota,2NANB@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SRR25158203_k127_3467897_6	1459636.NTE_01895	8.776e-13	80.0	COG1502@1|root,arCOG02039@2157|Archaea	2157|Archaea	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
SRR25158203_k127_3467897_4	391623.TERMP_01535	9.81e-30	129.0	COG0640@1|root,arCOG00472@2157|Archaea,2XTGC@28890|Euryarchaeota,242XF@183968|Thermococci	183968|Thermococci	L	Pfam:Arch_ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA
SRR25158203_k127_3467897_5	679926.Mpet_2647	6.706e-25	113.0	arCOG09549@1|root,arCOG09549@2157|Archaea,2Y5FI@28890|Euryarchaeota,2NB9S@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3467897_3	269797.Mbar_A1765	6.447e-44	169.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2NADX@224756|Methanomicrobia	224756|Methanomicrobia	K	PhoU domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SRR25158203_k127_3487306_0	1379698.RBG1_1C00001G0955	4.989e-53	196.0	COG0457@1|root,COG0457@2|Bacteria,2NPK1@2323|unclassified Bacteria	2|Bacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
SRR25158203_k127_3487306_3	192952.MM_1112	2.359e-21	95.0	arCOG04980@1|root,arCOG04980@2157|Archaea,2Y1ZN@28890|Euryarchaeota,2NA2W@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3487306_2	351160.LRC241	1.022e-46	171.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
SRR25158203_k127_3487306_1	304371.MCP_0210	6.342e-50	187.0	COG0463@1|root,arCOG01386@2157|Archaea,2Y7ST@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR25158203_k127_3487306_4	192952.MM_0292	8.505e-15	77.0	COG3390@1|root,arCOG02257@2157|Archaea,2XTM4@28890|Euryarchaeota,2N9JC@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
SRR25158203_k127_349022_2	192952.MM_3074	1.424e-72	248.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
SRR25158203_k127_349022_0	269797.Mbar_A1793	5.108e-232	721.0	COG0535@1|root,arCOG00938@2157|Archaea,2XUJG@28890|Euryarchaeota,2N9IV@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
SRR25158203_k127_349022_1	1094980.Mpsy_1381	3.661e-121	395.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,2N92D@224756|Methanomicrobia	224756|Methanomicrobia	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_349022_3	304371.MCP_1488	2.899e-10	61.0	COG3328@1|root,arCOG04918@2157|Archaea	2157|Archaea	L	PFAM Transposase, Mutator family	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
SRR25158203_k127_3499427_7	439235.Dalk_1820	2.724e-10	65.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2MISZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Cytochrome c, bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrome_C554,Cytochrome_cB
SRR25158203_k127_3499427_2	316067.Geob_1593	7.554e-96	322.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
SRR25158203_k127_3499427_1	1379698.RBG1_1C00001G0773	3.355e-123	407.0	COG5557@1|root,COG5557@2|Bacteria,2NQYU@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	hmcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NrfD
SRR25158203_k127_3499427_4	269797.Mbar_A0128	6.22e-55	198.0	COG3161@1|root,arCOG01031@2157|Archaea,2XX77@28890|Euryarchaeota,2NAT8@224756|Methanomicrobia	224756|Methanomicrobia	H	Protein of unknown function (DUF98)	-	-	-	-	-	-	-	-	-	-	-	-	DUF98
SRR25158203_k127_3499427_6	351160.RRC338	2.602e-26	111.0	COG4004@1|root,arCOG04412@2157|Archaea,2Y12M@28890|Euryarchaeota,2N9YP@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3499427_5	192952.MM_2017	6.112e-42	167.0	arCOG02780@1|root,arCOG02780@2157|Archaea,2XZQI@28890|Euryarchaeota,2N9W5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3499427_3	269797.Mbar_A1751	8.384e-90	306.0	COG1693@1|root,arCOG02711@2157|Archaea,2XUUJ@28890|Euryarchaeota,2N94A@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function DUF128	-	-	-	ko:K21640	-	-	-	-	ko00000	-	-	-	DUF128
SRR25158203_k127_3499427_0	589865.DaAHT2_0965	1.989e-210	670.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,2MKEW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
SRR25158203_k127_3499427_8	386456.JQKN01000001_gene1767	5.644e-05	45.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,23P57@183925|Methanobacteria	183925|Methanobacteria	H	Biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
SRR25158203_k127_351311_2	673860.AciM339_1442	1.967e-88	300.0	COG2414@1|root,arCOG00706@2157|Archaea,2XTUP@28890|Euryarchaeota,3F35P@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	aor1	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SRR25158203_k127_351311_1	192952.MM_1343	9.639e-94	317.0	COG0042@1|root,arCOG00604@2157|Archaea,2XY3T@28890|Euryarchaeota,2NAKI@224756|Methanomicrobia	224756|Methanomicrobia	J	Dihydrouridine synthase (Dus)	-	-	-	-	-	-	-	-	-	-	-	-	Dus
SRR25158203_k127_351311_3	639282.DEFDS_0706	2.03e-65	233.0	COG0672@1|root,COG0672@2|Bacteria,2GGKP@200930|Deferribacteres	200930|Deferribacteres	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
SRR25158203_k127_351311_5	383372.Rcas_3322	6.36e-49	182.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,2G6N4@200795|Chloroflexi,375K6@32061|Chloroflexia	32061|Chloroflexia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
SRR25158203_k127_351311_0	868131.MSWAN_0522	2.079e-140	471.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,23NWG@183925|Methanobacteria	183925|Methanobacteria	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
SRR25158203_k127_351311_4	351160.RCIX2570	4.141e-61	213.0	COG0563@1|root,arCOG01046@2157|Archaea,2XTRG@28890|Euryarchaeota,2N9GB@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0086	ADK,ADK_lid
SRR25158203_k127_3518887_2	1041930.Mtc_0359	7.089e-18	84.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,2N920@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Semialdehyde dehydrogenase NAD - binding	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SRR25158203_k127_3518887_3	589924.Ferp_1544	2.815e-17	83.0	COG1146@1|root,arCOG00959@2157|Archaea,2XZV5@28890|Euryarchaeota,246G0@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SRR25158203_k127_3518887_1	593750.Metfor_2530	3.86e-24	117.0	arCOG09579@1|root,arCOG09579@2157|Archaea,2Y58J@28890|Euryarchaeota,2NBAR@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3518887_0	192952.MM_1365	2.747e-86	292.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,2N9G5@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SRR25158203_k127_3527533_10	1229520.ADIAL_1489	4.786e-16	78.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,27FDJ@186828|Carnobacteriaceae	91061|Bacilli	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRR25158203_k127_3527533_4	1111479.AXAR01000002_gene1899	6.963e-108	353.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,2784A@186823|Alicyclobacillaceae	91061|Bacilli	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRR25158203_k127_3527533_5	387631.Asulf_00050	2.132e-75	262.0	COG1028@1|root,arCOG01259@2157|Archaea,2XSWX@28890|Euryarchaeota,2469N@183980|Archaeoglobi	183980|Archaeoglobi	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059,ko:K07535	ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220	M00083,M00540,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRR25158203_k127_3527533_0	269797.Mbar_A0575	2.626e-212	677.0	COG0303@1|root,arCOG00217@2157|Archaea,2XT2V@28890|Euryarchaeota,2N9DX@224756|Methanomicrobia	224756|Methanomicrobia	H	MoeA domain protein domain I and II	moeA-1	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
SRR25158203_k127_3527533_3	192952.MM_0708	1.191e-108	362.0	COG2038@1|root,arCOG04272@2157|Archaea,2XTPU@28890|Euryarchaeota,2N9K1@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3527533_1	351160.RCIX283	2.763e-157	507.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,2N98U@224756|Methanomicrobia	224756|Methanomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
SRR25158203_k127_3527533_8	192952.MM_0821	1.605e-30	124.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y0G2@28890|Euryarchaeota,2NA2F@224756|Methanomicrobia	224756|Methanomicrobia	L	metal ion binding	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_4
SRR25158203_k127_3527533_9	304371.MCP_0111	1.062e-23	103.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,2N9YJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
SRR25158203_k127_3527533_6	997346.HMPREF9374_0506	3.293e-52	193.0	COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,4HC5V@91061|Bacilli,27B2M@186824|Thermoactinomycetaceae	91061|Bacilli	L	Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen	ku	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
SRR25158203_k127_3527533_7	645991.Sgly_2857	4.986e-44	170.0	COG1427@1|root,COG1427@2|Bacteria,1V2PX@1239|Firmicutes,24CGN@186801|Clostridia,2618R@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
SRR25158203_k127_3527533_11	395965.Msil_0345	5.186e-13	74.0	COG3794@1|root,COG3794@2|Bacteria,1NKZ5@1224|Proteobacteria	1224|Proteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
SRR25158203_k127_3527533_2	1094980.Mpsy_1449	1.366e-141	460.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
SRR25158203_k127_3527983_2	1094980.Mpsy_2191	5.802e-74	252.0	COG0826@1|root,arCOG03202@2157|Archaea,2XVBU@28890|Euryarchaeota	28890|Euryarchaeota	O	Peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U32
SRR25158203_k127_3527983_1	1094980.Mpsy_1914	8.076e-79	272.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,2N9NJ@224756|Methanomicrobia	224756|Methanomicrobia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	iAF692.Mbar_A1332	PseudoU_synth_1
SRR25158203_k127_3527983_0	192952.MM_1496	1.722e-83	285.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,2N9HA@224756|Methanomicrobia	224756|Methanomicrobia	Q	RNA methylase	trmL	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
SRR25158203_k127_3575444_0	868131.MSWAN_0926	4.393e-111	366.0	COG0438@1|root,arCOG01403@2157|Archaea,2XVAJ@28890|Euryarchaeota,23PHK@183925|Methanobacteria	183925|Methanobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_3575444_2	710686.Mycsm_00921	4.136e-54	204.0	COG0438@1|root,COG0438@2|Bacteria,2IDYW@201174|Actinobacteria,236IE@1762|Mycobacteriaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SRR25158203_k127_3575444_1	386456.JQKN01000005_gene507	3.723e-86	302.0	COG2244@1|root,arCOG02209@2157|Archaea,2XSUR@28890|Euryarchaeota	28890|Euryarchaeota	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
SRR25158203_k127_358240_0	192952.MM_1394	2.531e-161	519.0	COG1797@1|root,arCOG00106@2157|Archaea,2XTIE@28890|Euryarchaeota,2N95E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source	cbiA-2	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
SRR25158203_k127_358240_2	693661.Arcve_1554	1.248e-122	419.0	COG5427@1|root,arCOG00563@2157|Archaea,2XV1K@28890|Euryarchaeota,246X2@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
SRR25158203_k127_358240_1	351160.RCIX1383	3.585e-123	401.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,2N922@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SRR25158203_k127_358240_3	1094980.Mpsy_1890	6e-71	244.0	COG0131@1|root,arCOG04398@2157|Archaea,2XT2K@28890|Euryarchaeota,2N9NB@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1310	IGPD
SRR25158203_k127_3602168_0	192952.MM_1410	3.559e-35	151.0	arCOG03489@1|root,arCOG03489@2157|Archaea	192952.MM_1410|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3602168_1	204669.Acid345_2713	3.706e-34	143.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
SRR25158203_k127_3602168_2	671143.DAMO_0825	2.273e-11	66.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NNNM@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b subunit of formate dehydrogenase-like protein	mccA	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016002,GO:0016043,GO:0016491,GO:0016667,GO:0017144,GO:0019748,GO:0020037,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044272,GO:0044550,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051259,GO:0051260,GO:0055114,GO:0065003,GO:0070206,GO:0070207,GO:0070813,GO:0070814,GO:0071840,GO:0097159,GO:1901363,GO:1903136	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1
SRR25158203_k127_3621924_1	1094980.Mpsy_1792	9.412e-79	267.0	COG1859@1|root,arCOG04063@2157|Archaea,2XWPC@28890|Euryarchaeota,2N9J7@224756|Methanomicrobia	224756|Methanomicrobia	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
SRR25158203_k127_3621924_0	351160.RCIX1029	1.28e-125	409.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,2N99Z@224756|Methanomicrobia	224756|Methanomicrobia	F	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
SRR25158203_k127_3621924_2	1041930.Mtc_0455	9.268e-56	200.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2N9RS@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
SRR25158203_k127_3621924_3	1094980.Mpsy_1596	4.262e-45	166.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,2N9YA@224756|Methanomicrobia	224756|Methanomicrobia	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
SRR25158203_k127_3621924_4	479434.Sthe_1545	1.971e-21	97.0	COG5553@1|root,COG5553@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I
SRR25158203_k127_3628364_10	1047013.AQSP01000037_gene1327	6.579e-08	54.0	COG1063@1|root,COG1063@2|Bacteria,2NPK3@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SRR25158203_k127_3628364_1	1459636.NTE_02180	1.834e-106	351.0	COG1830@1|root,arCOG04044@2157|Archaea,41S64@651137|Thaumarchaeota	651137|Thaumarchaeota	E	DeoC/LacD family aldolase	-	-	2.3.1.245	ko:K08321	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	DeoC
SRR25158203_k127_3628364_11	1041930.Mtc_2243	4.094e-07	57.0	arCOG06692@1|root,arCOG06692@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3628364_4	1094980.Mpsy_0258	2.163e-73	253.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,2N9JZ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
SRR25158203_k127_3628364_0	269797.Mbar_A1394	2.467e-187	588.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,2N96C@224756|Methanomicrobia	224756|Methanomicrobia	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SRR25158203_k127_3628364_9	304371.MCP_2618	8.326e-11	66.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,2NA4E@224756|Methanomicrobia	224756|Methanomicrobia	J	Gar1/Naf1 RNA binding region	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
SRR25158203_k127_3628364_3	1094980.Mpsy_0990	5.154e-85	287.0	COG1387@1|root,arCOG00304@2157|Archaea,2XVZY@28890|Euryarchaeota,2N90M@224756|Methanomicrobia	224756|Methanomicrobia	E	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
SRR25158203_k127_3628364_6	192952.MM_1557	6.856e-30	123.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y68X@28890|Euryarchaeota,2NA5V@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
SRR25158203_k127_3628364_2	1175306.GWL_15060	4.286e-96	325.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,472DU@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
SRR25158203_k127_3628364_5	368407.Memar_1039	5.099e-69	239.0	COG1392@1|root,arCOG02640@2157|Archaea	2157|Archaea	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SRR25158203_k127_3628364_8	635013.TherJR_2126	2.373e-16	79.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,261TB@186807|Peptococcaceae	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
SRR25158203_k127_362896_4	521011.Mpal_1132	8.557e-16	78.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SRR25158203_k127_362896_0	44251.PDUR_10230	4.202e-63	226.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	ko:K16129	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	Hydrolase_4,Methyltransf_11,Methyltransf_20,Methyltransf_25,Methyltransf_31,Ubie_methyltran
SRR25158203_k127_362896_7	192952.MM_0388	7.937e-07	54.0	COG2048@1|root,arCOG00965@2157|Archaea,2XYMZ@28890|Euryarchaeota,2NBF4@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S dicluster domain	hdrC-1	-	1.8.7.3	ko:K22482	ko00680,map00680	-	R11931	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4_8
SRR25158203_k127_362896_9	1041930.Mtc_1471	3.363e-06	50.0	COG1148@1|root,arCOG02236@2157|Archaea,2XV85@28890|Euryarchaeota,2NABC@224756|Methanomicrobia	224756|Methanomicrobia	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3	ko:K22480	ko00680,map00680	-	R11931	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
SRR25158203_k127_362896_2	269797.Mbar_A1577	3.205e-28	128.0	arCOG03267@1|root,arCOG03267@2157|Archaea	2157|Archaea	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
SRR25158203_k127_362896_5	1123399.AQVE01000001_gene746	1.398e-14	76.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
SRR25158203_k127_362896_8	573063.Metin_1213	1.799e-06	55.0	COG1553@1|root,arCOG02068@2157|Archaea,2XYJ8@28890|Euryarchaeota,23R0A@183939|Methanococci	183939|Methanococci	P	PFAM DsrE family protein	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
SRR25158203_k127_362896_3	1220534.B655_1175	1.031e-18	90.0	COG1553@1|root,arCOG02068@2157|Archaea,2Y0VW@28890|Euryarchaeota	28890|Euryarchaeota	P	DsrE/DsrF-like family	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
SRR25158203_k127_362896_6	1027273.GZ77_17870	5.806e-08	58.0	COG1553@1|root,COG1553@2|Bacteria,1NDPA@1224|Proteobacteria,1SFY2@1236|Gammaproteobacteria,1XQIZ@135619|Oceanospirillales	135619|Oceanospirillales	P	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
SRR25158203_k127_362896_1	1123354.AUDR01000012_gene1725	1.554e-29	119.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VKEW@28216|Betaproteobacteria,1KRJK@119069|Hydrogenophilales	119069|Hydrogenophilales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR25158203_k127_3632491_0	351160.RCIX1184	2.026e-136	440.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N947@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM 26S proteasome subunit P45 family	pan-1	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
SRR25158203_k127_3632491_2	693661.Arcve_1406	4.53e-88	298.0	COG0663@1|root,arCOG01849@2157|Archaea,2Y0WS@28890|Euryarchaeota	28890|Euryarchaeota	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
SRR25158203_k127_3632491_3	1343739.PAP_00920	4.84e-75	257.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,244E3@183968|Thermococci	183968|Thermococci	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR25158203_k127_3632491_8	1125863.JAFN01000001_gene3405	2.817e-15	88.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SRR25158203_k127_3632491_7	593750.Metfor_0507	7.975e-23	111.0	COG1361@1|root,arCOG02080@2157|Archaea,2Y0I6@28890|Euryarchaeota,2N9ZF@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
SRR25158203_k127_3632491_6	679926.Mpet_2740	3.944e-36	146.0	COG2881@1|root,arCOG03630@2157|Archaea,2XYDD@28890|Euryarchaeota,2NBAT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
SRR25158203_k127_3632491_1	1094980.Mpsy_1518	4.772e-124	407.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2N9UX@224756|Methanomicrobia	224756|Methanomicrobia	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
SRR25158203_k127_3632491_4	1094980.Mpsy_1519	2.183e-57	207.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2N9X2@224756|Methanomicrobia	224756|Methanomicrobia	L	Segregation and condensation protein ScpA	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
SRR25158203_k127_3632491_5	269797.Mbar_A1006	2.705e-41	154.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,2N9E5@224756|Methanomicrobia	224756|Methanomicrobia	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
SRR25158203_k127_3663656_0	555779.Dthio_PD3593	1.337e-207	649.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,42N9K@68525|delta/epsilon subdivisions,2WINH@28221|Deltaproteobacteria,2M8V9@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM N-6 DNA methylase	hsdM	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
SRR25158203_k127_3663656_1	386456.JQKN01000006_gene1262	6.175e-59	209.0	COG1708@1|root,arCOG01208@2157|Archaea,2Y0ZT@28890|Euryarchaeota	28890|Euryarchaeota	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
SRR25158203_k127_3663656_2	1151117.AJLF01000001_gene978	5.347e-32	129.0	COG1895@1|root,arCOG02123@2157|Archaea,2Y6HV@28890|Euryarchaeota,244KS@183968|Thermococci	183968|Thermococci	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
SRR25158203_k127_3675857_1	1094980.Mpsy_1780	1.178e-127	417.0	COG0620@1|root,arCOG01878@2157|Archaea,2XWEP@28890|Euryarchaeota,2NA99@224756|Methanomicrobia	224756|Methanomicrobia	E	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1023	-
SRR25158203_k127_3675857_0	269797.Mbar_A1787	3.366e-132	431.0	COG1223@1|root,arCOG04163@2157|Archaea,2XUPW@28890|Euryarchaeota,2NAFR@224756|Methanomicrobia	224756|Methanomicrobia	O	AAA domain (Cdc48 subfamily)	-	-	-	ko:K07392	-	-	-	-	ko00000	-	-	-	AAA
SRR25158203_k127_3677025_0	1094980.Mpsy_2182	4.249e-143	459.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2N996@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
SRR25158203_k127_3677025_5	1094980.Mpsy_2183	1.26e-16	82.0	COG4064@1|root,arCOG03380@2157|Archaea,2Y18S@28890|Euryarchaeota,2NA2X@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrG	-	2.1.1.86	ko:K00583	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrG
SRR25158203_k127_3677025_4	1094980.Mpsy_2184	4.875e-20	91.0	COG4218@1|root,arCOG03381@2157|Archaea	2157|Archaea	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrF	-	2.1.1.86	ko:K00582	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1257	MtrF
SRR25158203_k127_3677025_1	1094980.Mpsy_2185	2.037e-88	297.0	COG4063@1|root,arCOG03221@2157|Archaea,2XWSE@28890|Euryarchaeota,2N9GK@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrG	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA,MtrG
SRR25158203_k127_3677025_3	1094980.Mpsy_2186	3.352e-24	106.0	COG4062@1|root,arCOG04867@2157|Archaea,2Y0C7@28890|Euryarchaeota,2NA0I@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrB	-	2.1.1.86	ko:K00578	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrB
SRR25158203_k127_3677025_2	1041930.Mtc_0938	5.26e-25	108.0	COG4061@1|root,arCOG04868@2157|Archaea,2XYI9@28890|Euryarchaeota,2N9JF@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrC	-	2.1.1.86	ko:K00579	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrC
SRR25158203_k127_3702302_2	869213.JCM21142_3835	3.143e-07	61.0	COG0697@1|root,COG0697@2|Bacteria,4NIBF@976|Bacteroidetes	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRR25158203_k127_3702302_0	269797.Mbar_A2850	1.057e-188	599.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,2N970@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	iAF692.Mbar_A2850	Enolase_C,Enolase_N
SRR25158203_k127_3702302_1	1343739.PAP_00010	1.278e-07	59.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
SRR25158203_k127_370663_5	679926.Mpet_1697	6.277e-51	186.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,2N9GN@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
SRR25158203_k127_370663_2	192952.MM_1425	5.268e-145	478.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,2N9BA@224756|Methanomicrobia	224756|Methanomicrobia	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
SRR25158203_k127_370663_1	261292.Nit79A3_1327	5.305e-197	627.0	COG0402@1|root,COG0402@2|Bacteria,1R9S5@1224|Proteobacteria,2W13M@28216|Betaproteobacteria,37499@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SRR25158203_k127_370663_6	273063.STK_17440	7.506e-41	170.0	arCOG03430@1|root,arCOG03430@2157|Archaea	2157|Archaea	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
SRR25158203_k127_370663_3	192952.MM_2030	9.563e-75	256.0	COG0118@1|root,arCOG00089@2157|Archaea,2XTJ7@28890|Euryarchaeota,2N9N4@224756|Methanomicrobia	224756|Methanomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
SRR25158203_k127_370663_0	192952.MM_2031	1.505e-202	639.0	COG1973@1|root,arCOG00637@2157|Archaea,2XVGM@28890|Euryarchaeota,2N91N@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM AIR synthase related protein	-	-	-	ko:K07388	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SRR25158203_k127_370663_7	525897.Dbac_0541	4.141e-36	143.0	COG1986@1|root,COG1986@2|Bacteria,1Q6S4@1224|Proteobacteria,433PP@68525|delta/epsilon subdivisions,2WX89@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Protein of unknown function DUF84	-	-	-	-	-	-	-	-	-	-	-	-	NTPase_I-T
SRR25158203_k127_370663_8	394503.Ccel_1735	8.335e-30	125.0	arCOG11023@1|root,2ZBVW@2|Bacteria,1V1HI@1239|Firmicutes,24G3M@186801|Clostridia,36INM@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_370663_12	1094980.Mpsy_3096	9.392e-06	54.0	arCOG02933@1|root,arCOG02933@2157|Archaea,2Y56N@28890|Euryarchaeota,2NBBX@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_370663_9	877455.Metbo_2202	6.592e-29	119.0	COG0375@1|root,arCOG04426@2157|Archaea,2XZI2@28890|Euryarchaeota,23P60@183925|Methanobacteria	183925|Methanobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
SRR25158203_k127_370663_11	269797.Mbar_A2813	1.754e-10	65.0	arCOG04945@1|root,arCOG04945@2157|Archaea,2Y5TK@28890|Euryarchaeota,2NB8S@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_370663_4	192952.MM_2585	4.609e-54	198.0	COG0805@1|root,arCOG01919@2157|Archaea,2XV3R@28890|Euryarchaeota,2NAUW@224756|Methanomicrobia	224756|Methanomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC-1	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
SRR25158203_k127_370663_10	192952.MM_1365	5.528e-12	68.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,2N9G5@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SRR25158203_k127_3721873_4	589924.Ferp_0391	5.984e-20	95.0	arCOG00937@1|root,arCOG00937@2157|Archaea,2Y2E6@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
SRR25158203_k127_3721873_0	368408.Tpen_0750	5.431e-195	624.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
SRR25158203_k127_3721873_1	1410653.JHVC01000005_gene2487	3.379e-118	393.0	COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia,36EF4@31979|Clostridiaceae	186801|Clostridia	P	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
SRR25158203_k127_3721873_3	1227454.C446_06060	7.696e-25	106.0	COG4274@1|root,arCOG01119@2157|Archaea,2Y0ZG@28890|Euryarchaeota,23Y66@183963|Halobacteria	183963|Halobacteria	S	GYD family	-	-	-	-	-	-	-	-	-	-	-	-	GYD
SRR25158203_k127_3721873_2	1123371.ATXH01000003_gene1893	1.134e-63	225.0	COG1926@1|root,COG1926@2|Bacteria	2|Bacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
SRR25158203_k127_3721873_5	1382306.JNIM01000001_gene2696	7.225e-06	49.0	COG1488@1|root,COG1488@2|Bacteria,2G70D@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	-
SRR25158203_k127_3729847_4	1143323.M787_0557	2.435e-67	235.0	COG0215@1|root,COG0215@2|Bacteria,2JFNB@204428|Chlamydiae	204428|Chlamydiae	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
SRR25158203_k127_3729847_3	1459636.NTE_03061	4.464e-70	245.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRR25158203_k127_3729847_0	1459636.NTE_03060	1.721e-114	377.0	COG1131@1|root,arCOG00196@2157|Archaea,41S73@651137|Thaumarchaeota	651137|Thaumarchaeota	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR25158203_k127_3729847_6	1094980.Mpsy_2826	8.135e-17	84.0	arCOG03400@1|root,arCOG03400@2157|Archaea,2Y17X@28890|Euryarchaeota,2NA59@224756|Methanomicrobia	224756|Methanomicrobia	S	nucleic acid binding OB-fold tRNA helicase-type	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_anti-codon
SRR25158203_k127_3729847_5	224325.AF_0177	7.831e-36	143.0	COG2191@1|root,arCOG00762@2157|Archaea,2XYR8@28890|Euryarchaeota	28890|Euryarchaeota	C	formylmethanofuran dehydrogenase, subunit E	fwdE	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
SRR25158203_k127_3729847_2	521674.Plim_2933	4.734e-86	298.0	COG0659@1|root,COG0659@2|Bacteria,2J2QM@203682|Planctomycetes	203682|Planctomycetes	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
SRR25158203_k127_3729847_1	224325.AF_0161	1.971e-86	299.0	COG0303@1|root,arCOG00216@2157|Archaea,2XT05@28890|Euryarchaeota	28890|Euryarchaeota	H	Molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
SRR25158203_k127_3730427_2	192952.MM_1317	3.003e-123	403.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,2N9FF@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis	mfnA	-	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
SRR25158203_k127_3730427_3	1157490.EL26_19650	4.563e-122	402.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,4IS7E@91061|Bacilli,278RE@186823|Alicyclobacillaceae	91061|Bacilli	E	Methionine gamma-lyase	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
SRR25158203_k127_3730427_7	192952.MM_3243	1.079e-30	132.0	arCOG06746@1|root,arCOG06746@2157|Archaea,2Y5GC@28890|Euryarchaeota	28890|Euryarchaeota	S	Pfam:DUF422	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
SRR25158203_k127_3730427_0	1173026.Glo7428_0079	0.0	1032.0	COG1049@1|root,COG1049@2|Bacteria,1G12I@1117|Cyanobacteria	1117|Cyanobacteria	C	Belongs to the aconitase IPM isomerase family	acnB	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0045333,GO:0046395,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:0097159,GO:1901363,GO:1901575	4.2.1.3,4.2.1.99	ko:K01682	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173	R01324,R01325,R01900,R04425	RC00497,RC00498,RC00618,RC01153	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_2_N,Aconitase_B_N
SRR25158203_k127_3730427_4	1094980.Mpsy_1224	1.257e-66	239.0	COG1624@1|root,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota,2N9M8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	dacZ	-	-	-	-	-	-	-	-	-	-	-	DisA_N
SRR25158203_k127_3730427_9	269797.Mbar_A1275	1.916e-17	91.0	arCOG02874@1|root,arCOG02874@2157|Archaea,2Y43V@28890|Euryarchaeota,2NB28@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3730427_8	673860.AciM339_1477	6.332e-24	111.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,3F2K5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
SRR25158203_k127_3730427_6	192952.MM_1293	6.403e-33	132.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2NA25@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
SRR25158203_k127_3730427_1	192952.MM_0114	1.411e-172	552.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SRR25158203_k127_3730427_10	797209.ZOD2009_22142	0.0001948	53.0	COG1404@1|root,COG3420@1|root,arCOG03606@1|root,arCOG06738@1|root,arCOG00702@2157|Archaea,arCOG02519@2157|Archaea,arCOG03606@2157|Archaea,arCOG06738@2157|Archaea,2XTGN@28890|Euryarchaeota,23TTV@183963|Halobacteria	183963|Halobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CarboxypepD_reg,Peptidase_S8
SRR25158203_k127_3730427_5	1210908.HSB1_42480	7.605e-57	226.0	COG2304@1|root,arCOG07561@1|root,arCOG02902@2157|Archaea,arCOG07561@2157|Archaea,2XUQK@28890|Euryarchaeota,23TQB@183963|Halobacteria	183963|Halobacteria	K	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3731205_6	237368.SCABRO_02898	1.581e-29	132.0	COG5653@1|root,COG5653@2|Bacteria	2|Bacteria	M	Protein involved in cellulose biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
SRR25158203_k127_3731205_1	1094980.Mpsy_1111	4.223e-89	301.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
SRR25158203_k127_3731205_4	192952.MM_2157	2.16e-61	213.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,2N9RP@224756|Methanomicrobia	224756|Methanomicrobia	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
SRR25158203_k127_3731205_2	1094980.Mpsy_1113	4.977e-71	245.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,2N9QT@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
SRR25158203_k127_3731205_5	1041930.Mtc_1531	3.541e-53	196.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SRR25158203_k127_3731205_0	1220534.B655_0826	2.711e-166	530.0	COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,23NPK@183925|Methanobacteria	183925|Methanobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SRR25158203_k127_3731205_3	386456.JQKN01000001_gene2185	6.02e-62	214.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,23PMF@183925|Methanobacteria	183925|Methanobacteria	C	Fe-S cluster	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SRR25158203_k127_3731205_7	269797.Mbar_A0533	8.327e-25	107.0	COG2522@1|root,arCOG00017@2157|Archaea,2Y1WV@28890|Euryarchaeota,2NA61@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	HTH_3
SRR25158203_k127_3741455_6	1094980.Mpsy_2594	3.863e-36	143.0	COG1776@1|root,arCOG02381@2157|Archaea,2XTT2@28890|Euryarchaeota,2N9ZW@224756|Methanomicrobia	224756|Methanomicrobia	N	CheC inhibitor of MCP methylation	-	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	-
SRR25158203_k127_3741455_4	350688.Clos_1509	4.24e-44	165.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,36I61@31979|Clostridiaceae	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
SRR25158203_k127_3741455_5	192952.MM_0517	1.103e-40	154.0	COG2138@1|root,arCOG02246@2157|Archaea,2XTSY@28890|Euryarchaeota,2N9W8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin	cbiX	-	4.99.1.11,4.99.1.3	ko:K22011	ko00860,ko01100,map00860,map01100	M00836	R05807,R11626	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2400	CbiX
SRR25158203_k127_3741455_1	192952.MM_0516	1.055e-108	367.0	COG0770@1|root,arCOG02822@2157|Archaea,2XX2Y@28890|Euryarchaeota,2N9JG@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Mur ligase, middle domain protein	murD	-	6.4.1.9	ko:K21612	ko00860,ko01120,map00860,map01120	M00836	R11629	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
SRR25158203_k127_3741455_0	269797.Mbar_A0061	9.184e-133	429.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2N91B@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-2	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SRR25158203_k127_3741455_2	1094980.Mpsy_0916	3.991e-80	272.0	COG0284@1|root,arCOG00081@2157|Archaea,2XU66@28890|Euryarchaeota,2N9J4@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0060	OMPdecase
SRR25158203_k127_3741455_3	589924.Ferp_0426	4.517e-65	235.0	COG0582@1|root,arCOG01242@2157|Archaea,2Y83U@28890|Euryarchaeota,246MT@183980|Archaeoglobi	28890|Euryarchaeota	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
SRR25158203_k127_375427_3	953739.SVEN_7203	1.206e-14	83.0	COG2304@1|root,COG3227@1|root,COG2304@2|Bacteria,COG3227@2|Bacteria,2IE4G@201174|Actinobacteria	201174|Actinobacteria	E	Zinc metalloprotease (Elastase)	-	-	-	ko:K20274	ko02024,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	-
SRR25158203_k127_375427_0	572546.Arcpr_1618	9.665e-144	475.0	COG1001@1|root,arCOG00693@2157|Archaea,2XV8C@28890|Euryarchaeota,246QY@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
SRR25158203_k127_375427_1	1094980.Mpsy_0965	3.164e-35	145.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,2N9NX@224756|Methanomicrobia	224756|Methanomicrobia	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
SRR25158203_k127_375427_4	665571.STHERM_c14960	6.939e-11	69.0	28WAT@1|root,2ZIB9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_375427_2	1104324.P186_1785	8.151e-20	90.0	COG3350@1|root,arCOG04507@2157|Archaea,2XR9V@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
SRR25158203_k127_3773787_3	304371.MCP_1339	0.0006157	42.0	COG3316@1|root,arCOG02134@2157|Archaea	2157|Archaea	L	COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1,HTH_Tnp_1
SRR25158203_k127_3773787_1	273063.STK_11750	1.375e-36	141.0	COG1146@1|root,arCOG04548@2157|Archaea	2157|Archaea	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ferB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
SRR25158203_k127_3773787_0	671065.MetMK1DRAFT_00014070	3.227e-149	490.0	COG0674@1|root,arCOG01606@2157|Archaea,2XQ12@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
SRR25158203_k127_3793199_1	1094980.Mpsy_2896	7.851e-67	237.0	COG0705@1|root,COG3582@1|root,arCOG01768@2157|Archaea,arCOG01769@2157|Archaea,2XTJH@28890|Euryarchaeota,2N9X9@224756|Methanomicrobia	224756|Methanomicrobia	E	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
SRR25158203_k127_3793199_6	1220534.B655_0683	0.0004809	47.0	arCOG10459@1|root,arCOG10459@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3793199_5	386456.JQKN01000011_gene795	5.968e-31	123.0	COG0640@1|root,arCOG00731@2157|Archaea,2XYSK@28890|Euryarchaeota	2157|Archaea	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
SRR25158203_k127_3793199_0	1094980.Mpsy_0101	3.928e-70	243.0	COG0535@1|root,arCOG00938@2157|Archaea	2157|Archaea	P	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SRR25158203_k127_3793199_2	604354.TSIB_1503	6.541e-65	232.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SRR25158203_k127_3793199_3	192952.MM_2593	1.464e-53	201.0	COG0697@1|root,arCOG00274@2157|Archaea,2Y0MY@28890|Euryarchaeota,2NARA@224756|Methanomicrobia	224756|Methanomicrobia	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRR25158203_k127_3793199_4	192952.MM_1366	6.003e-51	189.0	COG1180@1|root,arCOG00952@2157|Archaea,2XZ0I@28890|Euryarchaeota,2N9XE@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	nrdG	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SRR25158203_k127_3881524_3	192952.MM_2356	2.518e-32	127.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,2NA0B@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
SRR25158203_k127_3881524_2	1094980.Mpsy_3163	1.522e-43	162.0	COG1885@1|root,arCOG02119@2157|Archaea,2XX3M@28890|Euryarchaeota,2N9T5@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0212 family	-	-	-	ko:K09731	-	-	-	-	ko00000	-	-	-	DUF555
SRR25158203_k127_3881524_0	269797.Mbar_A2904	1.003e-89	301.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,2NAV9@224756|Methanomicrobia	224756|Methanomicrobia	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
SRR25158203_k127_3881524_1	1094980.Mpsy_1636	2.875e-45	173.0	COG1468@1|root,arCOG00793@2157|Archaea,2Y05J@28890|Euryarchaeota,2NA1Y@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
SRR25158203_k127_3900619_0	1111479.AXAR01000001_gene307	2.246e-113	377.0	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,4HAI4@91061|Bacilli,2780C@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	iYO844.BSU31750	NAPRTase
SRR25158203_k127_3900619_2	795359.TOPB45_0862	2.254e-36	141.0	COG3543@1|root,COG3543@2|Bacteria,2GI0C@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function (DUF1284)	-	-	-	ko:K09706	-	-	-	-	ko00000	-	-	-	DUF1284
SRR25158203_k127_3900619_1	1094980.Mpsy_1295	2.759e-65	231.0	COG1411@1|root,arCOG00616@2157|Archaea,2XYJ0@28890|Euryarchaeota,2N9PP@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SRR25158203_k127_3900619_3	211586.SO_4533	1.237e-05	55.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RCFZ@1224|Proteobacteria,1S2QS@1236|Gammaproteobacteria,2QEEF@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
SRR25158203_k127_3946511_0	118168.MC7420_6697	6.31e-63	219.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria,1H7JR@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_3946511_2	1121403.AUCV01000013_gene3928	8.976e-49	177.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,42T9C@68525|delta/epsilon subdivisions,2WP3Z@28221|Deltaproteobacteria,2MKTX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
SRR25158203_k127_3946511_1	404589.Anae109_3161	2.879e-60	222.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase A domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,sCache_3_2
SRR25158203_k127_3946511_4	247490.KSU1_B0579	1.163e-32	140.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,2IZWU@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
SRR25158203_k127_3946511_3	1304888.ATWF01000002_gene119	2.232e-38	157.0	COG4892@1|root,COG4892@2|Bacteria,2GFKG@200930|Deferribacteres	200930|Deferribacteres	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
SRR25158203_k127_3953377_2	386456.JQKN01000004_gene148	3.454e-36	141.0	COG0784@1|root,arCOG06537@2157|Archaea,2XWYJ@28890|Euryarchaeota	28890|Euryarchaeota	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4,PAS_9,PadR,Response_reg
SRR25158203_k127_3953377_1	386456.JQKN01000004_gene147	1.456e-91	306.0	COG0467@1|root,arCOG01171@2157|Archaea,2XXJX@28890|Euryarchaeota	28890|Euryarchaeota	T	KaiC	-	-	-	ko:K07331	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ATPase
SRR25158203_k127_3953377_0	706587.Desti_3183	2.025e-137	471.0	COG2202@1|root,COG4191@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria,42QA2@68525|delta/epsilon subdivisions,2X7QC@28221|Deltaproteobacteria,2MQRX@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS_9
SRR25158203_k127_3958111_4	552811.Dehly_1194	1.763e-86	289.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SRR25158203_k127_3958111_13	869209.Tresu_1451	0.0003197	48.0	COG0727@1|root,COG0727@2|Bacteria,2J85V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SRR25158203_k127_3958111_11	589924.Ferp_1695	1.528e-10	64.0	COG3432@1|root,arCOG01055@2157|Archaea,2Y15R@28890|Euryarchaeota,247GS@183980|Archaeoglobi	183980|Archaeoglobi	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR25158203_k127_3958111_2	192952.MM_2511	2.259e-114	377.0	COG1548@1|root,arCOG04369@2157|Archaea,2XVPP@28890|Euryarchaeota,2N9IT@224756|Methanomicrobia	224756|Methanomicrobia	K	Hydantoinase/oxoprolinase	-	-	2.5.1.131	ko:K07072	ko00680,map00680	-	R11040	RC01372,RC03335	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_A
SRR25158203_k127_3958111_6	304371.MCP_1712	9.152e-56	199.0	COG2061@1|root,arCOG04396@2157|Archaea,2XWMD@28890|Euryarchaeota,2N9PF@224756|Methanomicrobia	224756|Methanomicrobia	E	amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3958111_0	192952.MM_2713	2.046e-125	409.0	COG0460@1|root,arCOG01351@2157|Archaea,2XSWF@28890|Euryarchaeota,2N91A@224756|Methanomicrobia	224756|Methanomicrobia	E	homoserine dehydrogenase	thrA	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
SRR25158203_k127_3958111_3	269797.Mbar_A2406	7.545e-109	362.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
SRR25158203_k127_3958111_7	368407.Memar_0895	4.404e-17	83.0	COG5015@1|root,arCOG00528@2157|Archaea,2XY7F@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
SRR25158203_k127_3958111_10	797302.Halru_1437	1.993e-12	77.0	COG0382@1|root,arCOG00481@2157|Archaea,2XVK8@28890|Euryarchaeota,23S8B@183963|Halobacteria	183963|Halobacteria	H	COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases	ubiA3	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SRR25158203_k127_3958111_9	192952.MM_2507	7.676e-13	70.0	COG3385@1|root,arCOG03902@2157|Archaea,2XVZ6@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase IS4 family protein	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1
SRR25158203_k127_3958111_12	192952.MM_2507	0.0001283	47.0	COG3385@1|root,arCOG03902@2157|Archaea,2XVZ6@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase IS4 family protein	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1
SRR25158203_k127_3958111_5	279010.BL01111	4.316e-83	289.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli,1ZPV5@1386|Bacillus	91061|Bacilli	O	Belongs to the peptidase S8 family	aprE	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030193,GO:0030195,GO:0032101,GO:0032102,GO:0042730,GO:0043170,GO:0044238,GO:0048519,GO:0048583,GO:0048585,GO:0050789,GO:0050818,GO:0050819,GO:0050878,GO:0051239,GO:0051241,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070011,GO:0071704,GO:0080134,GO:0140096,GO:1900046,GO:1900047,GO:1901564,GO:1903034,GO:1903035	3.4.21.62	ko:K01342,ko:K13277	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I9,Peptidase_S8,SLH
SRR25158203_k127_3958111_1	387631.Asulf_01862	2.165e-121	401.0	COG1139@1|root,arCOG00335@2157|Archaea,2Y85J@28890|Euryarchaeota,246XX@183980|Archaeoglobi	28890|Euryarchaeota	C	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	Fer4_8,LUD_dom
SRR25158203_k127_3958111_8	269798.CHU_2633	1.849e-15	81.0	COG0475@1|root,COG0475@2|Bacteria,4NFPE@976|Bacteroidetes,47NZK@768503|Cytophagia	976|Bacteroidetes	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
SRR25158203_k127_3959234_0	304371.MCP_1721	1.89e-79	272.0	COG0095@1|root,arCOG01939@2157|Archaea,2XUJ0@28890|Euryarchaeota	28890|Euryarchaeota	H	COG0095 Lipoate-protein ligase A	lpl	GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SRR25158203_k127_3959234_2	1123052.AUDF01000002_gene654	3.049e-11	67.0	COG0095@1|root,COG0095@2|Bacteria,2GJV5@201174|Actinobacteria,4FKRX@85023|Microbacteriaceae	201174|Actinobacteria	H	biotin lipoate A B protein ligase	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
SRR25158203_k127_3959234_1	1041930.Mtc_0475	7.343e-50	184.0	COG0020@1|root,arCOG01532@2157|Archaea,2XU1R@28890|Euryarchaeota,2N9SY@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Di-trans-poly-cis-decaprenylcistransferase	uppS-1	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
SRR25158203_k127_3959234_3	351160.RCIX888	1.096e-06	54.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2N936@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
SRR25158203_k127_3969930_1	1094980.Mpsy_2650	1.852e-70	242.0	COG0693@1|root,arCOG00769@2157|Archaea,2XTPH@28890|Euryarchaeota,2N9UJ@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
SRR25158203_k127_3969930_2	243164.DET1124	1.316e-37	144.0	COG0347@1|root,COG0347@2|Bacteria,2G9JD@200795|Chloroflexi,34DDF@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
SRR25158203_k127_3969930_0	1121468.AUBR01000070_gene1040	1.135e-171	548.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,42F7G@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM Ammonium transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
SRR25158203_k127_3973958_3	1499968.TCA2_1670	9.881e-07	50.0	COG1028@1|root,COG1028@2|Bacteria,1TSND@1239|Firmicutes,4HAU2@91061|Bacilli,26RB5@186822|Paenibacillaceae	91061|Bacilli	IQ	reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SRR25158203_k127_3973958_0	1410653.JHVC01000008_gene3146	6.877e-134	436.0	COG3243@1|root,COG3243@2|Bacteria,1V0SA@1239|Firmicutes,24D2G@186801|Clostridia,36RAI@31979|Clostridiaceae	186801|Clostridia	I	PHB de-polymerase C-terminus	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
SRR25158203_k127_3973958_1	65393.PCC7424_0496	1.31e-09	66.0	28KIX@1|root,2ZA44@2|Bacteria,1G064@1117|Cyanobacteria,3KHKM@43988|Cyanothece	1117|Cyanobacteria	S	TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit	phaE	GO:0008150,GO:0008152,GO:0009058,GO:0042618,GO:0042619,GO:0071704,GO:1901440,GO:1901441,GO:1901576	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
SRR25158203_k127_3973958_2	1111134.HMPREF1253_1847	4.182e-08	64.0	28KIX@1|root,2ZA44@2|Bacteria,1UYPD@1239|Firmicutes,24ATH@186801|Clostridia,22GKY@1570339|Peptoniphilaceae	186801|Clostridia	S	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	phaE	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
SRR25158203_k127_3976587_4	387631.Asulf_00474	1.339e-20	103.0	arCOG10223@1|root,arCOG10223@2157|Archaea,2XXPY@28890|Euryarchaeota,2468J@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3976587_6	330779.Saci_0986	9.211e-10	70.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
SRR25158203_k127_3976587_7	693661.Arcve_0170	1.929e-09	64.0	arCOG10224@1|root,arCOG10224@2157|Archaea,2Y1WN@28890|Euryarchaeota,246J2@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_3976587_2	572546.Arcpr_0809	5.733e-57	209.0	COG0467@1|root,arCOG01171@2157|Archaea,2XYM8@28890|Euryarchaeota,24657@183980|Archaeoglobi	183980|Archaeoglobi	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SRR25158203_k127_3976587_5	1094980.Mpsy_1085	1.855e-13	72.0	COG1722@1|root,arCOG03646@2157|Archaea	2157|Archaea	L	PFAM Exonuclease VII small subunit	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
SRR25158203_k127_3976587_0	1094980.Mpsy_1086	8.701e-125	412.0	COG1570@1|root,arCOG04513@2157|Archaea,2XVDP@28890|Euryarchaeota,2NAAC@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM Exonuclease VII large subunit	-	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
SRR25158203_k127_3976587_3	1094980.Mpsy_1586	2.195e-38	149.0	COG1259@1|root,arCOG01759@2157|Archaea,2XWIM@28890|Euryarchaeota,2NA0M@224756|Methanomicrobia	224756|Methanomicrobia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
SRR25158203_k127_3976587_1	521011.Mpal_1134	3.535e-76	267.0	COG0715@1|root,arCOG01803@2157|Archaea	2157|Archaea	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	Lipoprotein_9,NMT1,NMT1_2,TctC
SRR25158203_k127_3980089_1	269797.Mbar_A0855	8.691e-74	256.0	COG1478@1|root,arCOG02714@2157|Archaea,2XTHI@28890|Euryarchaeota,2N9KE@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
SRR25158203_k127_3980089_0	1094980.Mpsy_2104	5.246e-154	495.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2N9CT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
SRR25158203_k127_3980089_2	269797.Mbar_A0723	7.447e-30	123.0	COG1246@1|root,arCOG00827@2157|Archaea,2Y4Z4@28890|Euryarchaeota,2NB6X@224756|Methanomicrobia	224756|Methanomicrobia	E	Acetyltransferase (GNAT) domain	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
SRR25158203_k127_3989790_9	192952.MM_1243	5.124e-43	162.0	COG4055@1|root,arCOG04859@2157|Archaea,2XZ5V@28890|Euryarchaeota,2NBJT@224756|Methanomicrobia	224756|Methanomicrobia	H	Methyl-coenzyme M reductase operon protein D	mcrD	-	-	ko:K03422	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	MCR_D
SRR25158203_k127_3989790_0	192952.MM_1244	2.761e-166	533.0	COG4054@1|root,arCOG04860@2157|Archaea,2XTPD@28890|Euryarchaeota,2N9BX@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Methyl-coenzyme M reductase, beta subunit	mcrB	-	2.8.4.1	ko:K00401	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04541	RC00011,RC01542	ko00000,ko00001,ko00002,ko01000	-	-	-	MCR_beta,MCR_beta_N
SRR25158203_k127_3989790_11	1041930.Mtc_0950	3.974e-05	51.0	COG4014@1|root,arCOG04846@2157|Archaea,2Y712@28890|Euryarchaeota,2NBEW@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2098)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2098
SRR25158203_k127_3989790_7	1041930.Mtc_1856	5.92e-64	229.0	COG4087@1|root,arCOG01579@2157|Archaea,2XXV0@28890|Euryarchaeota,2N9NS@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iAF692.Mbar_A0708	Hydrolase
SRR25158203_k127_3989790_3	1123319.AUBE01000015_gene5658	4.057e-103	344.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRR25158203_k127_3989790_2	138119.DSY0505	7.225e-109	361.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,260YJ@186807|Peptococcaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRR25158203_k127_3989790_6	1227454.C446_16080	2.574e-77	268.0	COG1173@1|root,arCOG00748@2157|Archaea,2XT5Z@28890|Euryarchaeota,23SJC@183963|Halobacteria	183963|Halobacteria	P	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SRR25158203_k127_3989790_5	1227454.C446_16085	1.939e-78	274.0	COG0601@1|root,arCOG00751@2157|Archaea,2XT0J@28890|Euryarchaeota,23SR6@183963|Halobacteria	183963|Halobacteria	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SRR25158203_k127_3989790_4	926690.KE386573_gene1836	5.654e-84	301.0	COG0747@1|root,arCOG01534@2157|Archaea,2XT8J@28890|Euryarchaeota,23SWD@183963|Halobacteria	183963|Halobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRR25158203_k127_3989790_8	926560.KE387027_gene707	6.028e-55	198.0	COG1765@1|root,COG1765@2|Bacteria,1WM1H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
SRR25158203_k127_3989790_10	1123371.ATXH01000035_gene1990	2.957e-36	140.0	COG0537@1|root,COG0537@2|Bacteria,2GHXG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	FG	HIT domain	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
SRR25158203_k127_3989790_1	1094980.Mpsy_2935	3.888e-132	426.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,2N9D1@224756|Methanomicrobia	224756|Methanomicrobia	E	Carbamoyl-phosphate synthase, small chain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
SRR25158203_k127_4029219_1	1094980.Mpsy_1650	8.129e-69	237.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,2N97Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
SRR25158203_k127_4029219_0	517418.Ctha_2310	1.449e-149	519.0	COG0745@1|root,COG2202@1|root,COG3829@1|root,COG3852@1|root,COG5000@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,COG5000@2|Bacteria,1FFR1@1090|Chlorobi	2|Bacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SRR25158203_k127_4029219_3	1094980.Mpsy_2671	1.356e-06	51.0	COG3344@1|root,arCOG03899@1|root,arCOG03317@2157|Archaea,arCOG03899@2157|Archaea,2XVTQ@28890|Euryarchaeota,2N984@224756|Methanomicrobia	224756|Methanomicrobia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1,RVT_N
SRR25158203_k127_4029219_2	1094980.Mpsy_2671	4.435e-31	125.0	COG3344@1|root,arCOG03899@1|root,arCOG03317@2157|Archaea,arCOG03899@2157|Archaea,2XVTQ@28890|Euryarchaeota,2N984@224756|Methanomicrobia	224756|Methanomicrobia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1,RVT_N
SRR25158203_k127_4056649_0	1173026.Glo7428_2698	3.536e-181	579.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_4056649_10	269797.Mbar_A0205	3.688e-14	81.0	COG0705@1|root,arCOG01768@2157|Archaea,2XTJH@28890|Euryarchaeota,2N9X9@224756|Methanomicrobia	224756|Methanomicrobia	E	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
SRR25158203_k127_4056649_2	931276.Cspa_c50420	2.275e-157	505.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
SRR25158203_k127_4056649_6	192952.MM_1110	1.191e-66	233.0	COG1810@1|root,arCOG02469@2157|Archaea,2XXEB@28890|Euryarchaeota,2NA3C@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF166
SRR25158203_k127_4056649_3	192952.MM_2283	8.59e-150	483.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,2N9EA@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	dfp	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
SRR25158203_k127_4056649_8	237368.SCABRO_03905	1.984e-26	111.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4056649_11	388467.A19Y_4225	5.139e-09	57.0	2CIXY@1|root,338DR@2|Bacteria,1G934@1117|Cyanobacteria,1HDGE@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4056649_12	756067.MicvaDRAFT_3893	0.0002274	44.0	2CIXY@1|root,338DR@2|Bacteria,1G934@1117|Cyanobacteria,1HDGE@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4056649_9	1047013.AQSP01000117_gene639	9.924e-19	91.0	COG1708@1|root,COG1708@2|Bacteria,2NRY3@2323|unclassified Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_4056649_7	269799.Gmet_3258	1.119e-26	114.0	COG2445@1|root,COG2445@2|Bacteria,1Q09M@1224|Proteobacteria,4374Y@68525|delta/epsilon subdivisions,2X2K9@28221|Deltaproteobacteria,43VVJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SRR25158203_k127_4056649_1	1094980.Mpsy_2214	2.646e-166	570.0	arCOG03256@1|root,arCOG03256@2157|Archaea,2Y1RB@28890|Euryarchaeota	28890|Euryarchaeota	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
SRR25158203_k127_4056649_5	269797.Mbar_A0822	3.769e-67	235.0	COG3482@1|root,arCOG05002@2157|Archaea,2XXHR@28890|Euryarchaeota,2N9MU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM TfuA domain protein, core	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
SRR25158203_k127_4056649_4	269797.Mbar_A0821	8.108e-143	464.0	COG1944@1|root,arCOG02882@2157|Archaea,2XUE0@28890|Euryarchaeota,2N9AP@224756|Methanomicrobia	224756|Methanomicrobia	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
SRR25158203_k127_4066897_6	1469607.KK073769_gene5200	1.573e-54	194.0	COG0262@1|root,COG0262@2|Bacteria,1G6PW@1117|Cyanobacteria,1HP02@1161|Nostocales	1117|Cyanobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
SRR25158203_k127_4066897_9	237368.SCABRO_03569	1.362e-17	88.0	29WUZ@1|root,30IGG@2|Bacteria,2J4C2@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4066897_11	646529.Desaci_1335	2.041e-06	51.0	2DNM3@1|root,32Y2K@2|Bacteria	2|Bacteria	S	Hydrid cluster protein-associated redox disulfide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
SRR25158203_k127_4066897_1	192952.MM_0282	3.588e-196	617.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,2N96D@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC-1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRR25158203_k127_4066897_10	1101188.KI912156_gene4020	1.639e-08	63.0	COG0671@1|root,COG0671@2|Bacteria,2I92V@201174|Actinobacteria,1WA4Q@1268|Micrococcaceae	201174|Actinobacteria	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
SRR25158203_k127_4066897_3	192952.MM_1767	1.016e-115	381.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2N97R@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SRR25158203_k127_4066897_0	269797.Mbar_A1418	1.006e-224	702.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia	224756|Methanomicrobia	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
SRR25158203_k127_4066897_2	192952.MM_1764	2.192e-140	454.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,2N94G@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
SRR25158203_k127_4066897_5	1094980.Mpsy_0884	1.634e-71	252.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,2N9PA@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SRR25158203_k127_4066897_4	192952.MM_1762	4.568e-102	340.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2N96Q@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SRR25158203_k127_4066897_8	877455.Metbo_1151	1.019e-22	100.0	COG2329@1|root,arCOG05403@2157|Archaea,2Y22C@28890|Euryarchaeota	28890|Euryarchaeota	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4066897_7	290399.Arth_2023	3.545e-32	128.0	COG1359@1|root,COG1359@2|Bacteria,2GT9F@201174|Actinobacteria	201174|Actinobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4066897_12	290399.Arth_2023	4.673e-06	49.0	COG1359@1|root,COG1359@2|Bacteria,2GT9F@201174|Actinobacteria	201174|Actinobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4066897_13	1158345.JNLL01000001_gene934	4.319e-05	48.0	COG2886@1|root,COG2886@2|Bacteria	2|Bacteria	E	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
SRR25158203_k127_4089243_4	1094980.Mpsy_2346	4.749e-50	192.0	COG3351@1|root,COG3352@1|root,arCOG02964@2157|Archaea,arCOG05119@2157|Archaea,2XVP0@28890|Euryarchaeota	28890|Euryarchaeota	N	flagella protein	flaD	-	-	ko:K07327,ko:K07328	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_fla_DE,FlaC_arch
SRR25158203_k127_4089243_2	1094980.Mpsy_1783	9.006e-81	276.0	COG0467@1|root,arCOG01171@2157|Archaea,2XTXF@28890|Euryarchaeota	28890|Euryarchaeota	T	RecA-superfamily ATPases implicated in signal transduction	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SRR25158203_k127_4089243_7	1094980.Mpsy_0106	9.213e-08	59.0	arCOG05803@1|root,arCOG05803@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4089243_0	1094980.Mpsy_1663	2.546e-83	300.0	COG0840@1|root,COG2770@1|root,arCOG02347@1|root,arCOG06712@1|root,arCOG02344@2157|Archaea,arCOG02347@2157|Archaea,arCOG02372@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,MCPsignal,PAS,PAS_3,PAS_4,PAS_8,PAS_9
SRR25158203_k127_4089243_6	1094980.Mpsy_0050	4.948e-45	168.0	COG0835@1|root,arCOG02395@2157|Archaea,2XWHD@28890|Euryarchaeota,2NBIP@224756|Methanomicrobia	224756|Methanomicrobia	N	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
SRR25158203_k127_4089243_1	1094980.Mpsy_1292	4.8e-82	301.0	COG0840@1|root,arCOG02342@1|root,arCOG02318@2157|Archaea,arCOG02342@2157|Archaea,arCOG02344@2157|Archaea,2Y7N2@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,PAS,PAS_4,PAS_9
SRR25158203_k127_4089243_5	1094980.Mpsy_0923	9.051e-46	171.0	COG0835@1|root,arCOG02395@2157|Archaea,2XWHD@28890|Euryarchaeota,2NBIP@224756|Methanomicrobia	224756|Methanomicrobia	N	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
SRR25158203_k127_4089243_3	1220589.CD32_18020	4.849e-58	220.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,3IWZN@400634|Lysinibacillus	91061|Bacilli	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
SRR25158203_k127_4094924_0	1094980.Mpsy_2934	1.647e-224	701.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,2N92M@224756|Methanomicrobia	224756|Methanomicrobia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2374	CPSase_L_D2,CPSase_L_D3,MGS
SRR25158203_k127_4094924_2	720554.Clocl_4207	2.861e-22	106.0	COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,25ESC@186801|Clostridia,3WJTG@541000|Ruminococcaceae	186801|Clostridia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_4094924_1	1379698.RBG1_1C00001G1196	8.047e-26	109.0	COG1371@1|root,COG1371@2|Bacteria,2NPX9@2323|unclassified Bacteria	2|Bacteria	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
SRR25158203_k127_4096687_1	269797.Mbar_A1571	3.039e-72	261.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
SRR25158203_k127_4096687_0	1094980.Mpsy_1158	3.02e-84	287.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia	224756|Methanomicrobia	L	8-oxoguanine DNA glycosylase domain protein	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
SRR25158203_k127_4096687_3	243164.DET1501	1.532e-38	149.0	COG0716@1|root,COG0716@2|Bacteria,2GAZ4@200795|Chloroflexi,34DME@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4096687_4	868131.MSWAN_0341	6.604e-35	137.0	COG3832@1|root,arCOG05261@2157|Archaea,2XYEH@28890|Euryarchaeota	28890|Euryarchaeota	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SRR25158203_k127_4096687_2	1429046.RR21198_1574	2.167e-53	193.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria,4G0EJ@85025|Nocardiaceae	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
SRR25158203_k127_4096687_5	269798.CHU_2554	4.139e-15	81.0	COG3832@1|root,COG3832@2|Bacteria,4NT4P@976|Bacteroidetes,47R8X@768503|Cytophagia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SRR25158203_k127_4096687_6	176299.Atu8153	1.644e-12	73.0	29AKN@1|root,2ZXKK@2|Bacteria,1RE01@1224|Proteobacteria,2U7J8@28211|Alphaproteobacteria,4BKXH@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4096687_7	868131.MSWAN_0341	4.402e-09	59.0	COG3832@1|root,arCOG05261@2157|Archaea,2XYEH@28890|Euryarchaeota	28890|Euryarchaeota	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
SRR25158203_k127_411443_2	192952.MM_0299	4.251e-134	436.0	COG1208@1|root,arCOG00666@2157|Archaea,2XTK6@28890|Euryarchaeota,2NBNZ@224756|Methanomicrobia	224756|Methanomicrobia	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SRR25158203_k127_411443_1	1094980.Mpsy_1841	6.143e-206	647.0	COG1004@1|root,arCOG00253@2157|Archaea,2XTQY@28890|Euryarchaeota,2N99M@224756|Methanomicrobia	224756|Methanomicrobia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1119,iAF692.Mbar_A1120	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SRR25158203_k127_411443_0	269797.Mbar_A0229	1.109e-216	680.0	COG0836@1|root,arCOG02427@2157|Archaea,2XUHF@28890|Euryarchaeota,2N9CC@224756|Methanomicrobia	224756|Methanomicrobia	M	TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	-	-	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0229	MannoseP_isomer,NTP_transferase
SRR25158203_k127_411443_3	1094980.Mpsy_2375	1.766e-105	346.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2NAI6@224756|Methanomicrobia	224756|Methanomicrobia	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SRR25158203_k127_4124376_3	877455.Metbo_0632	1.208e-46	172.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,23PGN@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	EF-hand_5,Peptidase_M48
SRR25158203_k127_4124376_2	1094980.Mpsy_2677	7.377e-47	176.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	3.4.24.84	ko:K03799,ko:K06013	ko00900,ko01130,map00900,map01130	M00743	R09845	RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48
SRR25158203_k127_4124376_4	1094980.Mpsy_2678	5.486e-41	156.0	COG3682@1|root,arCOG05764@2157|Archaea,2Y1AW@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
SRR25158203_k127_4124376_1	742767.HMPREF9456_01255	7.745e-65	228.0	COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,2FPUV@200643|Bacteroidia,22WHW@171551|Porphyromonadaceae	976|Bacteroidetes	E	C-terminus of AA_permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
SRR25158203_k127_4124376_0	192952.MM_3331	2.887e-72	258.0	COG1233@1|root,arCOG01524@2157|Archaea,2XSYN@28890|Euryarchaeota,2NA9X@224756|Methanomicrobia	224756|Methanomicrobia	Q	GDP dissociation inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
SRR25158203_k127_4194023_4	1158318.ATXC01000001_gene150	3.316e-66	243.0	COG1215@1|root,COG1215@2|Bacteria,2G4H2@200783|Aquificae	200783|Aquificae	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
SRR25158203_k127_4194023_6	706587.Desti_1849	1.6e-27	130.0	COG0726@1|root,COG0726@2|Bacteria,1QZSR@1224|Proteobacteria,43D4Q@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,Polysacc_deac_1
SRR25158203_k127_4194023_2	192952.MM_1877	9.851e-124	405.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,2N9AT@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Diphthamide synthesis DPH2 protein	dph2	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
SRR25158203_k127_4194023_0	192952.MM_1284	3.492e-222	698.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,2N9FJ@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
SRR25158203_k127_4194023_3	192952.MM_0675	4.343e-111	367.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2N9IY@224756|Methanomicrobia	224756|Methanomicrobia	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
SRR25158203_k127_4194023_5	1041930.Mtc_0861	2.655e-32	130.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,2N9TP@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
SRR25158203_k127_4194023_1	1206733.BAGC01000035_gene3637	2.365e-129	430.0	COG4257@1|root,COG4257@2|Bacteria,2GUYF@201174|Actinobacteria,4FXUH@85025|Nocardiaceae	201174|Actinobacteria	V	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4243352_0	269797.Mbar_A2149	3.245e-78	278.0	COG1122@1|root,arCOG00203@2157|Archaea,2Y7N4@28890|Euryarchaeota,2N9IS@224756|Methanomicrobia	224756|Methanomicrobia	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	iAF692.Mbar_A2149	ABC_tran
SRR25158203_k127_4243352_3	247490.KSU1_D0024	8.839e-15	85.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
SRR25158203_k127_4243352_2	1121342.AUCO01000022_gene3032	3.916e-56	207.0	COG0310@1|root,COG0310@2|Bacteria,1TQVK@1239|Firmicutes,248ZZ@186801|Clostridia,36EQF@31979|Clostridiaceae	186801|Clostridia	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
SRR25158203_k127_4243352_1	1094980.Mpsy_0763	8.301e-61	218.0	COG0675@1|root,arCOG00684@2157|Archaea,2XSWB@28890|Euryarchaeota,2NAE6@224756|Methanomicrobia	28890|Euryarchaeota	L	Probable transposase	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
SRR25158203_k127_4263576_10	504728.K649_04725	0.0001011	44.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096,Resolvase
SRR25158203_k127_4263576_0	269797.Mbar_A3613	0.0	1043.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SRR25158203_k127_4263576_3	1094980.Mpsy_0259	2.194e-150	480.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SRR25158203_k127_4263576_8	1183438.GKIL_1138	3.304e-13	76.0	COG1848@1|root,COG1848@2|Bacteria,1GA9D@1117|Cyanobacteria	1117|Cyanobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4263576_5	644281.MFS40622_1035	1.157e-84	295.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SRR25158203_k127_4263576_2	269797.Mbar_A0918	1.377e-201	635.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,2N99J@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SRR25158203_k127_4263576_6	316067.Geob_1640	7.974e-63	222.0	COG3861@1|root,COG3861@2|Bacteria,1QYWN@1224|Proteobacteria,43E8W@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
SRR25158203_k127_4263576_9	204773.HEAR1743	7.407e-09	57.0	2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,2VYEK@28216|Betaproteobacteria,4757D@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4263576_7	368407.Memar_0455	1.274e-57	209.0	arCOG01572@1|root,arCOG01572@2157|Archaea,2XUU7@28890|Euryarchaeota,2NAPE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Conserved TM helix repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
SRR25158203_k127_4263576_1	1094980.Mpsy_2851	8.552e-273	863.0	COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,2N9BE@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
SRR25158203_k127_4263576_4	1041930.Mtc_2238	3.287e-123	398.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
SRR25158203_k127_4278874_6	1094980.Mpsy_1837	3.183e-22	105.0	COG0582@1|root,arCOG01242@2157|Archaea,2Y83U@28890|Euryarchaeota,2NAAN@224756|Methanomicrobia	28890|Euryarchaeota	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
SRR25158203_k127_4278874_5	192952.MM_2514	6.402e-26	109.0	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota,2NA09@224756|Methanomicrobia	224756|Methanomicrobia	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
SRR25158203_k127_4278874_7	192952.MM_2513	4.941e-20	90.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y736@28890|Euryarchaeota,2NBEG@224756|Methanomicrobia	224756|Methanomicrobia	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
SRR25158203_k127_4278874_4	1041930.Mtc_0956	8.214e-59	209.0	COG2054@1|root,arCOG00859@2157|Archaea,2XVEI@28890|Euryarchaeota,2N9QG@224756|Methanomicrobia	224756|Methanomicrobia	S	aspartate glutamate uridylate kinase	-	-	2.7.4.31	ko:K07144	ko00680,map00680	-	R11039	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SRR25158203_k127_4278874_1	269797.Mbar_A1041	3.185e-157	501.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,2N95Z@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
SRR25158203_k127_4278874_2	192952.MM_3134	1.201e-113	374.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,2N972@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SRR25158203_k127_4278874_3	1094980.Mpsy_1049	1.648e-65	228.0	arCOG04740@1|root,arCOG04740@2157|Archaea,2XU9C@28890|Euryarchaeota,2N9U2@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4278874_0	351160.RCIX1963	1.094e-173	555.0	COG0019@1|root,arCOG02268@2157|Archaea,2XSY8@28890|Euryarchaeota,2N93Z@224756|Methanomicrobia	224756|Methanomicrobia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
SRR25158203_k127_4300424_0	1094980.Mpsy_2170	1.479e-228	718.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,2N9D5@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM histone acetyltransferase, ELP3 family	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
SRR25158203_k127_4300424_2	690850.Desaf_2977	1.067e-104	345.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42N8V@68525|delta/epsilon subdivisions,2WJWB@28221|Deltaproteobacteria,2M9ST@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
SRR25158203_k127_4300424_6	484770.UFO1_3553	2.731e-75	257.0	COG2249@1|root,COG2249@2|Bacteria,1U3MF@1239|Firmicutes,4H5ET@909932|Negativicutes	909932|Negativicutes	S	NADPH-dependent FMN reductase	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
SRR25158203_k127_4300424_5	304371.MCP_2317	8.577e-89	299.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2N931@224756|Methanomicrobia	224756|Methanomicrobia	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
SRR25158203_k127_4300424_3	1094980.Mpsy_2333	1.187e-102	344.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
SRR25158203_k127_4300424_7	1070774.J07HN4v3_03240	3.673e-47	183.0	COG0618@1|root,arCOG01566@2157|Archaea,2XT9H@28890|Euryarchaeota,23S5E@183963|Halobacteria	183963|Halobacteria	S	COG1226 Kef-type K transport systems	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1,TrkA_N
SRR25158203_k127_4300424_11	877455.Metbo_0678	1.996e-08	57.0	arCOG06415@1|root,arCOG06415@2157|Archaea	2157|Archaea	L	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	zf-HIT
SRR25158203_k127_4300424_9	693661.Arcve_0443	4.479e-14	74.0	COG2104@1|root,arCOG00535@2157|Archaea	2157|Archaea	H	Sulfur transfer protein involved in thiamine biosynthesis	samp2	GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564	2.8.1.15	ko:K03154,ko:K21947	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiS
SRR25158203_k127_4300424_8	1041930.Mtc_1641	4.14e-37	144.0	arCOG05517@1|root,arCOG05517@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4300424_4	269797.Mbar_A0270	2.501e-90	310.0	COG2006@1|root,arCOG02447@2157|Archaea,2XW1U@28890|Euryarchaeota,2N9D9@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_7
SRR25158203_k127_4300424_1	192952.MM_1391	5.238e-124	402.0	COG0496@1|root,arCOG02303@2157|Archaea,2XT5R@28890|Euryarchaeota,2N9DM@224756|Methanomicrobia	224756|Methanomicrobia	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1192	SurE
SRR25158203_k127_4300424_10	269797.Mbar_A2790	5.706e-09	59.0	arCOG04931@1|root,arCOG04931@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
SRR25158203_k127_4316395_14	323259.Mhun_1055	7.629e-25	106.0	COG0234@1|root,arCOG05153@2157|Archaea	2157|Archaea	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
SRR25158203_k127_4316395_0	639282.DEFDS_0240	1.031e-218	690.0	COG0459@1|root,COG0459@2|Bacteria,2GEY4@200930|Deferribacteres	200930|Deferribacteres	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
SRR25158203_k127_4316395_4	304371.MCP_1675	3.882e-135	442.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVWR@28890|Euryarchaeota,2NBG8@224756|Methanomicrobia	224756|Methanomicrobia	P	Arsenical pump membrane protein	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB,CitMHS
SRR25158203_k127_4316395_16	1459636.NTE_00289	6.371e-05	46.0	COG3039@1|root,arCOG02751@2157|Archaea	2157|Archaea	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
SRR25158203_k127_4316395_10	330214.NIDE0497	1.387e-65	246.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,3J0QY@40117|Nitrospirae	40117|Nitrospirae	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SRR25158203_k127_4316395_6	593750.Metfor_1618	3.153e-126	412.0	COG0158@1|root,arCOG04603@2157|Archaea,2XST8@28890|Euryarchaeota	28890|Euryarchaeota	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
SRR25158203_k127_4316395_11	1125971.ASJB01000031_gene1284	2.199e-35	149.0	COG1830@1|root,COG1830@2|Bacteria,2HPYY@201174|Actinobacteria,4E70X@85010|Pseudonocardiales	201174|Actinobacteria	G	Aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
SRR25158203_k127_4316395_13	269797.Mbar_A1940	3.561e-25	116.0	COG1047@1|root,arCOG00981@2157|Archaea,2XXFW@28890|Euryarchaeota,2NAZY@224756|Methanomicrobia	224756|Methanomicrobia	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
SRR25158203_k127_4316395_8	593750.Metfor_1644	1.493e-75	265.0	COG0668@1|root,arCOG01568@2157|Archaea,2XUW2@28890|Euryarchaeota,2N9TY@224756|Methanomicrobia	224756|Methanomicrobia	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
SRR25158203_k127_4316395_5	1094980.Mpsy_2886	4.594e-129	421.0	COG2768@1|root,arCOG02448@2157|Archaea,2XW30@28890|Euryarchaeota,2N9AE@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
SRR25158203_k127_4316395_12	269797.Mbar_A1240	9.549e-29	117.0	COG1225@1|root,arCOG00310@2157|Archaea,2XY0E@28890|Euryarchaeota,2NATM@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
SRR25158203_k127_4316395_1	368407.Memar_2034	4.987e-159	515.0	COG0477@1|root,arCOG00141@2157|Archaea,2Y3ND@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4316395_2	1094980.Mpsy_2837	6.377e-157	508.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,2N94D@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
SRR25158203_k127_4316395_9	1094980.Mpsy_1115	1.925e-73	260.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	ko:K19576	-	-	-	-	ko00000,ko02000	2.A.1.2.10	-	-	MFS_1
SRR25158203_k127_4316395_7	269797.Mbar_A0919	8.665e-89	295.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,2N9KA@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
SRR25158203_k127_4316395_3	485916.Dtox_0413	5.685e-138	450.0	2DPHU@1|root,3324S@2|Bacteria,1VSRB@1239|Firmicutes,2523E@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4334337_8	397948.Cmaq_1071	2.018e-06	52.0	COG0674@1|root,arCOG01606@2157|Archaea,2XPSM@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
SRR25158203_k127_4334337_0	1459636.NTE_01234	1.033e-146	470.0	COG1013@1|root,arCOG01599@2157|Archaea,41SAB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
SRR25158203_k127_4334337_4	374847.Kcr_0592	1.379e-12	77.0	COG0500@1|root,arCOG01791@2157|Archaea	2157|Archaea	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRR25158203_k127_4334337_7	706587.Desti_1167	3.367e-08	59.0	293FK@1|root,2ZQY0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4334337_5	1041522.MCOL_V201145	5.382e-10	69.0	COG0006@1|root,COG0006@2|Bacteria,2I9EK@201174|Actinobacteria,234B8@1762|Mycobacteriaceae	201174|Actinobacteria	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
SRR25158203_k127_4334337_6	316067.Geob_1374	4.19e-09	70.0	COG3880@1|root,COG3880@2|Bacteria	2|Bacteria	E	PFAM UvrB UvrC protein	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K08999,ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	Cytochrom_CIII,Cytochrome_C7,UVR
SRR25158203_k127_4334337_2	192952.MM_2233	3.348e-29	130.0	arCOG02538@1|root,arCOG02538@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,PKD,Peptidase_S8,S-layer
SRR25158203_k127_4334337_3	589924.Ferp_0670	1.009e-20	109.0	arCOG08705@1|root,arCOG08705@2157|Archaea	2157|Archaea	-	-	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	-
SRR25158203_k127_4334337_1	247490.KSU1_D0015	1.074e-48	177.0	COG0637@1|root,COG0637@2|Bacteria,2IZIM@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
SRR25158203_k127_4351607_1	269797.Mbar_A1122	1.856e-118	385.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2N966@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SRR25158203_k127_4351607_0	1173027.Mic7113_1195	6.427e-153	509.0	COG0784@1|root,COG3437@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1H8US@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
SRR25158203_k127_4351607_3	667632.KB890164_gene2209	2.5e-55	200.0	COG2208@1|root,COG2208@2|Bacteria,1N9UZ@1224|Proteobacteria	1224|Proteobacteria	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K05518	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
SRR25158203_k127_4351607_4	667632.KB890164_gene2210	6.728e-46	170.0	COG2172@1|root,COG2172@2|Bacteria,1MZIF@1224|Proteobacteria,2VSW8@28216|Betaproteobacteria,1K88Q@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase-like ATPases	-	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2
SRR25158203_k127_4351607_5	1206737.BAGF01000045_gene2831	1.102e-43	162.0	COG1366@1|root,COG1366@2|Bacteria,2IKVE@201174|Actinobacteria,4G0GD@85025|Nocardiaceae	201174|Actinobacteria	T	STAS domain	rsbS	-	-	ko:K17762	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
SRR25158203_k127_4351607_2	247156.NFA_11600	1.676e-95	321.0	COG1366@1|root,COG1366@2|Bacteria,2HPYR@201174|Actinobacteria,4FU8E@85025|Nocardiaceae	201174|Actinobacteria	T	STAS domain	rsbR	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	RsbRD_N,STAS
SRR25158203_k127_4351607_6	192952.MM_1518	5.847e-22	97.0	COG1772@1|root,arCOG04364@2157|Archaea,2XXJ6@28890|Euryarchaeota,2N9MC@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF531)	-	-	-	ko:K09725	-	-	-	-	ko00000	-	-	-	DUF531
SRR25158203_k127_4378226_12	1094980.Mpsy_1607	8.118e-22	97.0	COG0500@1|root,arCOG04989@2157|Archaea,2XYI7@28890|Euryarchaeota,2NBJ7@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR25158203_k127_4378226_3	593750.Metfor_1459	9.584e-83	278.0	COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
SRR25158203_k127_4378226_13	269797.Mbar_A3540	6.749e-13	75.0	arCOG03480@1|root,arCOG03480@2157|Archaea,2Y23D@28890|Euryarchaeota,2NA3K@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4378226_8	1094980.Mpsy_1411	7.005e-38	148.0	COG3364@1|root,arCOG04417@2157|Archaea,2Y0WK@28890|Euryarchaeota,2N9ZI@224756|Methanomicrobia	224756|Methanomicrobia	S	Zn-ribbon containing protein	-	-	-	ko:K07163	-	-	-	-	ko00000	-	-	-	DUF2072
SRR25158203_k127_4378226_7	368407.Memar_1792	1.005e-38	148.0	COG3365@1|root,arCOG04416@2157|Archaea,2XX2F@28890|Euryarchaeota,2N9XF@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2073)	-	-	-	ko:K09743	-	-	-	-	ko00000	-	-	-	DUF2073
SRR25158203_k127_4378226_2	1094980.Mpsy_1628	6.441e-106	346.0	COG1100@1|root,arCOG00354@2157|Archaea,2XT36@28890|Euryarchaeota,2N9A5@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GTP-binding protein HSR1-related	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	MMR_HSR1
SRR25158203_k127_4378226_1	1094980.Mpsy_2782	1.302e-210	662.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,2N978@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
SRR25158203_k127_4378226_11	269797.Mbar_A3499	2.19e-23	99.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,2NA67@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
SRR25158203_k127_4378226_10	304371.MCP_2284	2.011e-29	118.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,2NA2C@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Like-Sm ribonucleoprotein, core	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
SRR25158203_k127_4378226_6	351160.LRC235	2.96e-49	181.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,2N9WM@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
SRR25158203_k127_4378226_9	1094980.Mpsy_2716	3.698e-35	138.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2N9X3@224756|Methanomicrobia	224756|Methanomicrobia	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
SRR25158203_k127_4378226_4	1094980.Mpsy_2717	4.86e-61	217.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2N9T4@224756|Methanomicrobia	224756|Methanomicrobia	S	ZPR1-related zinc finger protein	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
SRR25158203_k127_4378226_0	56780.SYN_00521	0.0	1275.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MR4G@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
SRR25158203_k127_4378226_5	192952.MM_1410	5.952e-52	197.0	arCOG03489@1|root,arCOG03489@2157|Archaea	192952.MM_1410|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4384085_2	192952.MM_2233	1.38e-22	114.0	arCOG02538@1|root,arCOG02538@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,PKD,Peptidase_S8,S-layer
SRR25158203_k127_4384085_3	693661.Arcve_1866	1.557e-22	104.0	arCOG10329@1|root,arCOG10329@2157|Archaea,2XZKH@28890|Euryarchaeota,2475P@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4384085_0	593750.Metfor_0206	1.614e-98	336.0	arCOG04932@1|root,arCOG04932@2157|Archaea,2XY95@28890|Euryarchaeota,2N9QH@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4384085_6	386456.JQKN01000011_gene816	0.0002502	51.0	COG1522@1|root,arCOG01580@2157|Archaea,2XZQD@28890|Euryarchaeota,23PPJ@183925|Methanobacteria	183925|Methanobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SRR25158203_k127_4384085_1	224324.aq_262	3.21e-38	150.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
SRR25158203_k127_4384085_5	456442.Mboo_2036	2.214e-08	60.0	arCOG09606@1|root,arCOG09606@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF3147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3147
SRR25158203_k127_4384085_4	351160.RCIX977	1.753e-16	83.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2N9CT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
SRR25158203_k127_4389414_0	1125863.JAFN01000001_gene2788	7.165e-91	316.0	COG0348@1|root,COG3350@1|root,COG0348@2|Bacteria,COG3350@2|Bacteria,1R9MN@1224|Proteobacteria,42QKX@68525|delta/epsilon subdivisions,2WMMH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CT	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5,Sigma54_activat,cNMP_binding
SRR25158203_k127_4389414_2	1379698.RBG1_1C00001G0991	4.325e-19	101.0	COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria	2|Bacteria	Q	FlgD Ig-like domain	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_3,DUF1735,Laminin_G_3
SRR25158203_k127_4389414_1	348780.NP_2664A	3.777e-26	115.0	COG1522@1|root,arCOG01585@2157|Archaea,2XW1H@28890|Euryarchaeota,23VJ7@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	Arc_trans_TRASH,HTH_24,HTH_AsnC-type
SRR25158203_k127_4400234_5	1121912.AUHD01000007_gene374	1.988e-22	104.0	COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,1HY1D@117743|Flavobacteriia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
SRR25158203_k127_4400234_6	399550.Smar_0462	2.883e-07	58.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SRR25158203_k127_4400234_1	1041930.Mtc_0225	7.273e-319	990.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N91U@224756|Methanomicrobia	224756|Methanomicrobia	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
SRR25158203_k127_4400234_0	439481.Aboo_0405	0.0	1010.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,3F39E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
SRR25158203_k127_4400234_4	374847.Kcr_0228	1.195e-32	132.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	hsp20b	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SRR25158203_k127_4400234_3	269797.Mbar_A0909	1.34e-42	163.0	COG1777@1|root,arCOG01684@2157|Archaea,2XUMR@28890|Euryarchaeota,2NA1M@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K07721	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
SRR25158203_k127_4400234_2	443143.GM18_0105	9.461e-239	762.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42QGH@68525|delta/epsilon subdivisions,2WKTM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM multicopper oxidase type 2	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
SRR25158203_k127_4427704_4	269797.Mbar_A3407	2.679e-25	109.0	COG1143@1|root,arCOG01543@2157|Archaea,2XTIJ@28890|Euryarchaeota,2NAV0@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S dicluster domain	-	-	1.5.98.3	ko:K22164	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Fer4
SRR25158203_k127_4427704_5	561175.KB894093_gene4405	3.665e-13	72.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria,4EIJM@85012|Streptosporangiales	201174|Actinobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
SRR25158203_k127_4427704_3	1094980.Mpsy_2574	6.669e-33	130.0	COG0713@1|root,arCOG03073@2157|Archaea,2XXW4@28890|Euryarchaeota,2NB01@224756|Methanomicrobia	224756|Methanomicrobia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.5.98.3	ko:K22166	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Oxidored_q2
SRR25158203_k127_4427704_0	1094980.Mpsy_2575	9.315e-234	739.0	COG1009@1|root,arCOG01539@2157|Archaea,2XT4R@28890|Euryarchaeota,2NAAS@224756|Methanomicrobia	224756|Methanomicrobia	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.5.98.3	ko:K22167	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Proton_antipo_M,Proton_antipo_N
SRR25158203_k127_4427704_1	1094980.Mpsy_2576	1.142e-186	595.0	COG1008@1|root,arCOG01538@2157|Archaea,2XTP0@28890|Euryarchaeota,2NAFX@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton-conducting membrane transporter	-	-	1.5.98.3	ko:K22168	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	Proton_antipo_M
SRR25158203_k127_4427704_2	1094980.Mpsy_2577	1.242e-163	528.0	COG1007@1|root,arCOG01540@2157|Archaea,2XSY7@28890|Euryarchaeota,2N9SZ@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton-conducting membrane transporter	-	-	1.5.98.3	ko:K22169	-	-	-	-	ko00000,ko01000	3.D.9.1	-	iAF692.Mbar_A3401	Proton_antipo_M
SRR25158203_k127_4427704_6	192952.MM_2479	2.803e-12	71.0	arCOG04959@1|root,arCOG04959@2157|Archaea,2Y54W@28890|Euryarchaeota,2NB9W@224756|Methanomicrobia	224756|Methanomicrobia	C	F420H2 dehydrogenase subunit FpoO	-	-	1.5.98.3	ko:K22170	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	FpoO
SRR25158203_k127_4427704_7	1379270.AUXF01000004_gene3076	6.359e-07	56.0	COG2332@1|root,COG2332@2|Bacteria,1ZTNV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
SRR25158203_k127_4427969_7	304371.MCP_1064	0.0001348	45.0	COG4051@1|root,arCOG04904@2157|Archaea,2Y0XT@28890|Euryarchaeota,2N9XA@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2113)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2113
SRR25158203_k127_4427969_1	1094980.Mpsy_1570	1.617e-193	610.0	COG1924@1|root,arCOG02679@2157|Archaea,2XU50@28890|Euryarchaeota,2N92J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
SRR25158203_k127_4427969_4	351160.LRC169	2.51e-60	211.0	COG4050@1|root,arCOG04903@2157|Archaea,2XY68@28890|Euryarchaeota,2N9PJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2112
SRR25158203_k127_4427969_5	1094980.Mpsy_1572	1.347e-31	128.0	COG4029@1|root,arCOG04901@2157|Archaea,2XZQS@28890|Euryarchaeota,2N9W1@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2102)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2102
SRR25158203_k127_4427969_2	192952.MM_0912	3.954e-159	516.0	COG4070@1|root,arCOG04900@2157|Archaea,2XU32@28890|Euryarchaeota,2N90Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the UPF0288 family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4427969_0	269797.Mbar_A0707	6.235e-237	743.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-1	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
SRR25158203_k127_4427969_3	269797.Mbar_A0363	6.61e-105	347.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,2N92A@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
SRR25158203_k127_4427969_6	1094980.Mpsy_0179	1.153e-08	59.0	arCOG07235@1|root,arCOG07235@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4446246_0	1094980.Mpsy_0933	2.454e-244	767.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,2N9E6@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
SRR25158203_k127_4446246_8	192952.MM_1835	1.75e-22	100.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,2N9YQ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
SRR25158203_k127_4446246_11	192952.MM_1834	2.564e-09	66.0	arCOG05013@1|root,arCOG05013@2157|Archaea,2Y4Q3@28890|Euryarchaeota,2NB50@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4446246_5	1094980.Mpsy_0930	1.293e-61	226.0	COG1340@1|root,arCOG01159@2157|Archaea,2Y3I2@28890|Euryarchaeota,2NARG@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4446246_2	269797.Mbar_A0720	4.581e-136	442.0	COG1032@1|root,arCOG01356@2157|Archaea,2XUA3@28890|Euryarchaeota,2N9AZ@224756|Methanomicrobia	224756|Methanomicrobia	C	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR25158203_k127_4446246_9	1151117.AJLF01000002_gene141	4.446e-17	91.0	COG1750@1|root,arCOG01937@2157|Archaea,2XUEB@28890|Euryarchaeota,242IS@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
SRR25158203_k127_4446246_4	1094980.Mpsy_2088	6.191e-75	259.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MI@28890|Euryarchaeota,2NBNK@224756|Methanomicrobia	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SRR25158203_k127_4446246_1	269797.Mbar_A0871	2.393e-163	522.0	COG4992@1|root,arCOG00914@2157|Archaea,2XTKV@28890|Euryarchaeota,2N98X@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SRR25158203_k127_4446246_3	269797.Mbar_A0872	5.656e-134	436.0	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,2N91P@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SRR25158203_k127_4446246_7	269797.Mbar_A0258	4.399e-34	141.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,2N9V1@224756|Methanomicrobia	224756|Methanomicrobia	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
SRR25158203_k127_4446246_10	572546.Arcpr_1191	8.424e-17	86.0	arCOG03590@1|root,arCOG03590@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4446246_6	521460.Athe_2034	6.541e-52	184.0	COG2070@1|root,COG2070@2|Bacteria,1UJNK@1239|Firmicutes,25F6P@186801|Clostridia,42J79@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ferredoxin-dependent glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
SRR25158203_k127_4447845_5	1041930.Mtc_0430	8.439e-17	85.0	COG1645@1|root,arCOG00578@2157|Archaea,2Y1BV@28890|Euryarchaeota,2NA6C@224756|Methanomicrobia	224756|Methanomicrobia	S	Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
SRR25158203_k127_4447845_0	269797.Mbar_A1605	5.948e-145	469.0	COG0042@1|root,arCOG00605@2157|Archaea,2XU1I@28890|Euryarchaeota,2N9FE@224756|Methanomicrobia	224756|Methanomicrobia	J	Dihydrouridine synthase (Dus)	-	-	-	-	-	-	-	-	-	-	-	-	Dus
SRR25158203_k127_4447845_4	330214.NIDE0615	1.577e-30	125.0	COG0838@1|root,COG0838@2|Bacteria,3J0MS@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
SRR25158203_k127_4447845_1	1449126.JQKL01000022_gene118	1.324e-61	218.0	COG0377@1|root,COG0377@2|Bacteria,1TZS1@1239|Firmicutes,24GH5@186801|Clostridia	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
SRR25158203_k127_4447845_3	273075.Ta0968	2.966e-34	137.0	COG0852@1|root,arCOG01551@2157|Archaea,2XZK1@28890|Euryarchaeota,241U6@183967|Thermoplasmata	183967|Thermoplasmata	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
SRR25158203_k127_4447845_2	1329516.JPST01000014_gene513	9.645e-58	203.0	COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,4HA4Y@91061|Bacilli,27B48@186824|Thermoactinomycetaceae	91061|Bacilli	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
SRR25158203_k127_4474787_0	316067.Geob_3570	4.389e-225	711.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SRR25158203_k127_4474787_4	316067.Geob_3569	6.851e-43	158.0	COG4251@1|root,COG4251@2|Bacteria,1N1KJ@1224|Proteobacteria,42W7E@68525|delta/epsilon subdivisions,2WSCW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
SRR25158203_k127_4474787_5	316067.Geob_3568	1.31e-35	138.0	COG4251@1|root,COG4251@2|Bacteria,1N44A@1224|Proteobacteria,431XF@68525|delta/epsilon subdivisions,2WWPK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
SRR25158203_k127_4474787_3	1173020.Cha6605_5662	4.322e-45	177.0	COG2202@1|root,COG5000@1|root,COG2202@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria	1117|Cyanobacteria	T	TIGRFAM PAS domain S-box	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SRR25158203_k127_4474787_2	221288.JH992901_gene2375	1.511e-111	368.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria,1JI0S@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
SRR25158203_k127_4474787_1	926692.AZYG01000067_gene2065	9.314e-213	679.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WA7U@53433|Halanaerobiales	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
SRR25158203_k127_4478912_1	55529.EKX42656	3.671e-58	208.0	2D4PJ@1|root,2SVUS@2759|Eukaryota	2759|Eukaryota	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4478912_0	589924.Ferp_2432	7.344e-154	494.0	COG2046@1|root,arCOG04191@2157|Archaea,2XT7C@28890|Euryarchaeota,2464J@183980|Archaeoglobi	183980|Archaeoglobi	P	sulfate adenylyltransferase	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
SRR25158203_k127_4478912_2	269797.Mbar_A2420	9.269e-08	62.0	COG1413@1|root,arCOG02973@2157|Archaea,2Y2I3@28890|Euryarchaeota,2NAKY@224756|Methanomicrobia	224756|Methanomicrobia	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
SRR25158203_k127_4496922_2	351160.RCIX1586	9.577e-23	103.0	COG0655@1|root,arCOG00510@2157|Archaea	2157|Archaea	C	NAD(P)H dehydrogenase (quinone) activity	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
SRR25158203_k127_4496922_0	1094980.Mpsy_2384	2.618e-137	447.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
SRR25158203_k127_4496922_3	1158338.JNLJ01000005_gene1577	1.626e-17	89.0	COG1331@1|root,COG1331@2|Bacteria,2G3SJ@200783|Aquificae	200783|Aquificae	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
SRR25158203_k127_4496922_1	456442.Mboo_0112	2.285e-52	191.0	COG0632@1|root,arCOG06911@2157|Archaea,2Y4CP@28890|Euryarchaeota,2NAY8@224756|Methanomicrobia	224756|Methanomicrobia	L	RuvA, C-terminal domain	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
SRR25158203_k127_4496922_4	449447.MAE_52000	3.86e-06	51.0	COG0827@1|root,COG1002@1|root,COG2810@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,COG2810@2|Bacteria,1G051@1117|Cyanobacteria	1117|Cyanobacteria	V	Type II restriction enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,TaqI_C
SRR25158203_k127_4496922_5	744872.Spica_2160	0.0003683	45.0	COG2161@1|root,COG2161@2|Bacteria,2J8GQ@203691|Spirochaetes	203691|Spirochaetes	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
SRR25158203_k127_4499589_2	1094980.Mpsy_1529	6.514e-54	208.0	arCOG02911@1|root,arCOG02911@2157|Archaea,2XUPG@28890|Euryarchaeota,2NAYI@224756|Methanomicrobia	224756|Methanomicrobia	M	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4499589_3	1094980.Mpsy_1528	1.621e-43	169.0	arCOG02911@1|root,arCOG02911@2157|Archaea,2Y73A@28890|Euryarchaeota,2NB8D@224756|Methanomicrobia	224756|Methanomicrobia	M	toxin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4499589_7	1094980.Mpsy_1527	2.64e-19	94.0	arCOG03926@1|root,arCOG03926@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4499589_6	1094980.Mpsy_1526	9.329e-26	116.0	arCOG07777@1|root,arCOG07777@2157|Archaea,2Y74C@28890|Euryarchaeota,2NBAC@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4499589_4	1094980.Mpsy_1525	7.931e-41	158.0	arCOG04652@1|root,arCOG04652@2157|Archaea,2Y71V@28890|Euryarchaeota,2NB3Q@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4499589_1	1094980.Mpsy_1876	6.393e-95	322.0	COG1668@1|root,arCOG01470@2157|Archaea,2XU06@28890|Euryarchaeota,2N9QX@224756|Methanomicrobia	224756|Methanomicrobia	C	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
SRR25158203_k127_4499589_0	1094980.Mpsy_1877	6.334e-141	467.0	COG1668@1|root,arCOG04450@2157|Archaea,2XTRJ@28890|Euryarchaeota,2N9IA@224756|Methanomicrobia	224756|Methanomicrobia	C	COG1668 ABC-type Na efflux pump, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
SRR25158203_k127_4499589_5	1094980.Mpsy_1879	9.426e-33	129.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUT0@28890|Euryarchaeota,2N9J5@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR25158203_k127_4500343_1	1303518.CCALI_01936	2.046e-52	188.0	COG0652@1|root,COG0652@2|Bacteria	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
SRR25158203_k127_4500343_3	315749.Bcer98_3764	3.365e-17	87.0	COG2389@1|root,COG2389@2|Bacteria,1VN86@1239|Firmicutes,4HXX6@91061|Bacilli	91061|Bacilli	S	Uncharacterized metal-binding protein (DUF2227)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2227
SRR25158203_k127_4500343_0	1041930.Mtc_0323	1.191e-129	421.0	COG0113@1|root,arCOG04300@2157|Archaea,2XSZ8@28890|Euryarchaeota,2N97S@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
SRR25158203_k127_4500343_2	1094980.Mpsy_2427	9.838e-19	87.0	arCOG06141@1|root,arCOG06141@2157|Archaea,2Y28R@28890|Euryarchaeota	28890|Euryarchaeota	S	Family of unknown function (DUF5371)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5371
SRR25158203_k127_4519778_0	589924.Ferp_1932	2.373e-107	360.0	COG0477@1|root,arCOG00130@2157|Archaea,2XSTP@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRR25158203_k127_4519778_4	269799.Gmet_1157	6.006e-38	149.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,42U2Q@68525|delta/epsilon subdivisions,2WQK9@28221|Deltaproteobacteria,43UPT@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Membrane protein, UPF0016 and UPF0016 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
SRR25158203_k127_4519778_7	1122609.AUGT01000017_gene926	6.212e-05	48.0	2E54J@1|root,32ZXH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4519778_5	269797.Mbar_A2727	4.931e-12	67.0	arCOG02138@1|root,arCOG02138@2157|Archaea,2Y150@28890|Euryarchaeota,2NA0H@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4519778_6	378806.STAUR_3413	2.557e-10	69.0	2EHJS@1|root,33BBN@2|Bacteria,1NP80@1224|Proteobacteria,439MQ@68525|delta/epsilon subdivisions,2X4YU@28221|Deltaproteobacteria,2YZV4@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4519778_1	426368.MmarC7_0505	1.29e-96	331.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,23Q75@183939|Methanococci	183939|Methanococci	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRR25158203_k127_4519778_2	1094980.Mpsy_1927	1.998e-79	271.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,2N9K9@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0788	AA_kinase
SRR25158203_k127_4519778_3	1094980.Mpsy_1732	1.51e-51	188.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,2N97A@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
SRR25158203_k127_4523366_4	293826.Amet_3261	1.01e-24	106.0	COG2020@1|root,COG2020@2|Bacteria,1UXZ3@1239|Firmicutes,24T5J@186801|Clostridia,36N3W@31979|Clostridiaceae	186801|Clostridia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SRR25158203_k127_4523366_6	101510.RHA1_ro11232	3.934e-22	99.0	COG0640@1|root,COG0640@2|Bacteria,2IKPW@201174|Actinobacteria,4G2PA@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
SRR25158203_k127_4523366_1	192952.MM_3292	1.354e-51	184.0	COG1553@1|root,arCOG02068@2157|Archaea,2XYJ8@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM DsrE family protein	-	-	-	ko:K06039,ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
SRR25158203_k127_4523366_5	1162668.LFE_1240	1.926e-23	104.0	COG1765@1|root,COG1765@2|Bacteria	1162668.LFE_1240|-	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4523366_0	1041930.Mtc_1954	2.701e-77	269.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota	28890|Euryarchaeota	E	Leucyl aminopeptidase (Aminopeptidase t)	pepB1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
SRR25158203_k127_4523366_2	679926.Mpet_0429	1.001e-32	130.0	COG1733@1|root,arCOG01057@2157|Archaea,2XYND@28890|Euryarchaeota,2N9WD@224756|Methanomicrobia	224756|Methanomicrobia	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
SRR25158203_k127_4523366_7	1121861.KB899925_gene2569	0.0001484	47.0	COG5615@1|root,COG5615@2|Bacteria,1N3BK@1224|Proteobacteria,2UV0A@28211|Alphaproteobacteria,2JXRC@204441|Rhodospirillales	204441|Rhodospirillales	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
SRR25158203_k127_4523366_3	402777.KB235903_gene539	3.986e-28	123.0	COG4932@1|root,COG4932@2|Bacteria,1G0MJ@1117|Cyanobacteria,1H9HP@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B,Trypsin
SRR25158203_k127_4532603_14	868595.Desca_2408	1.233e-37	151.0	COG3212@1|root,COG3212@2|Bacteria,1VJGF@1239|Firmicutes,24RQ9@186801|Clostridia,262RI@186807|Peptococcaceae	186801|Clostridia	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4532603_12	1094508.Tsac_0929	1.024e-67	238.0	COG0500@1|root,COG2226@2|Bacteria,1TT7G@1239|Firmicutes,24E44@186801|Clostridia,42IAT@68295|Thermoanaerobacterales	186801|Clostridia	Q	NOG31153 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4532603_6	436308.Nmar_0642	3.019e-92	315.0	COG0389@1|root,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
SRR25158203_k127_4532603_19	272569.rrnAC1567	4.102e-21	96.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2XYMK@28890|Euryarchaeota,23WZZ@183963|Halobacteria	183963|Halobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
SRR25158203_k127_4532603_18	519442.Huta_2555	8.021e-26	113.0	COG2405@1|root,arCOG00717@2157|Archaea,2XX67@28890|Euryarchaeota,23VSU@183963|Halobacteria	183963|Halobacteria	V	nucleic acid-binding protein, contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
SRR25158203_k127_4532603_3	1094980.Mpsy_2853	1.29e-146	468.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,2N9DB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
SRR25158203_k127_4532603_9	293826.Amet_1174	1.513e-70	247.0	COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,36EWA@31979|Clostridiaceae	186801|Clostridia	P	ABC 3 transport family	adcB	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
SRR25158203_k127_4532603_8	279010.BL03701	7.528e-73	253.0	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,4HAZI@91061|Bacilli,1ZBS5@1386|Bacillus	91061|Bacilli	P	'COG1121 ABC-type Mn Zn transport systems, ATPase component'	zurA	-	-	ko:K02074,ko:K09817	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
SRR25158203_k127_4532603_7	696369.KI912183_gene1912	2.254e-86	295.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,261H2@186807|Peptococcaceae	186801|Clostridia	P	Belongs to the bacterial solute-binding protein 9 family	adcA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	iHN637.CLJU_RS18655	ZnuA
SRR25158203_k127_4532603_17	269797.Mbar_A0992	2.363e-31	128.0	COG1321@1|root,arCOG02100@2157|Archaea,2XXXA@28890|Euryarchaeota,2N9RI@224756|Methanomicrobia	224756|Methanomicrobia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
SRR25158203_k127_4532603_13	679926.Mpet_0719	5.303e-56	206.0	COG1920@1|root,arCOG04472@2157|Archaea,2XX3C@28890|Euryarchaeota,2N9RG@224756|Methanomicrobia	224756|Methanomicrobia	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
SRR25158203_k127_4532603_15	56110.Oscil6304_5893	1.093e-34	141.0	COG1150@1|root,COG1150@2|Bacteria,1G2B8@1117|Cyanobacteria	1117|Cyanobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8,Fer4_9
SRR25158203_k127_4532603_10	1173028.ANKO01000219_gene511	3.12e-69	244.0	COG2048@1|root,COG2048@2|Bacteria,1G2JG@1117|Cyanobacteria,1HERR@1150|Oscillatoriales	1117|Cyanobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SRR25158203_k127_4532603_2	439235.Dalk_1624	3.11e-159	529.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQ2S@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
SRR25158203_k127_4532603_16	1094980.Mpsy_1108	9.968e-33	129.0	arCOG04419@1|root,arCOG04419@2157|Archaea,2XZTP@28890|Euryarchaeota,2NA22@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2551)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2551
SRR25158203_k127_4532603_5	192952.MM_0608	5.102e-120	395.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,2N929@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
SRR25158203_k127_4532603_11	351160.RCIX2437	7.192e-68	241.0	COG0142@1|root,arCOG01726@2157|Archaea,2XT85@28890|Euryarchaeota,2NBHD@224756|Methanomicrobia	224756|Methanomicrobia	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SRR25158203_k127_4532603_1	1094980.Mpsy_0364	1.475e-173	551.0	COG0436@1|root,arCOG01133@2157|Archaea,2XU6A@28890|Euryarchaeota,2N9FK@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
SRR25158203_k127_4532603_0	1094980.Mpsy_0926	5.333e-261	814.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,2N90X@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM oxaloacetate decarboxylase alpha subunit	pycB	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1586	Biotin_lipoyl,HMGL-like,PYC_OADA
SRR25158203_k127_4532603_4	1094980.Mpsy_0927	3.779e-145	465.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
SRR25158203_k127_4569162_5	192952.MM_0836	1.973e-66	231.0	COG1232@1|root,arCOG01522@2157|Archaea,2XVES@28890|Euryarchaeota,2NAMB@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
SRR25158203_k127_4569162_2	269797.Mbar_A0505	2.024e-99	329.0	COG0392@1|root,arCOG00897@2157|Archaea,2XT65@28890|Euryarchaeota,2NA8D@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	Glycos_transf_2,LPG_synthase_TM
SRR25158203_k127_4569162_1	192952.MM_0839	8.049e-117	402.0	COG5427@1|root,arCOG00563@2157|Archaea,2XV1K@28890|Euryarchaeota,2NAMT@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
SRR25158203_k127_4569162_0	1094980.Mpsy_1191	0.0	1290.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
SRR25158203_k127_4569162_7	693661.Arcve_1632	2.851e-41	155.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
SRR25158203_k127_4569162_4	489825.LYNGBM3L_41950	1.795e-72	266.0	COG0467@1|root,COG0467@2|Bacteria,1G2XC@1117|Cyanobacteria,1H8VM@1150|Oscillatoriales	1117|Cyanobacteria	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SRR25158203_k127_4569162_9	1041930.Mtc_1242	0.0006068	47.0	arCOG13256@1|root,arCOG13256@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4569162_3	1167006.UWK_02103	8.842e-79	273.0	COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,42TZD@68525|delta/epsilon subdivisions,2WQIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Phosphonate ABC transporter, periplasmic	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
SRR25158203_k127_4569162_6	523845.AQXV01000053_gene681	1.7e-52	212.0	COG0840@1|root,arCOG02320@2157|Archaea,2Y7QV@28890|Euryarchaeota,23RVM@183939|Methanococci	183939|Methanococci	T	Integral membrane sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
SRR25158203_k127_4569162_8	1094980.Mpsy_2344	2.306e-19	89.0	COG0745@1|root,arCOG02595@2157|Archaea,2XZSB@28890|Euryarchaeota,2NAXV@224756|Methanomicrobia	224756|Methanomicrobia	T	cheY-homologous receiver domain	-	-	-	ko:K07668	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SRR25158203_k127_4594645_4	269797.Mbar_A0255	2.1e-87	303.0	COG1035@1|root,arCOG02650@2157|Archaea,2Y7JA@28890|Euryarchaeota,2NAMG@224756|Methanomicrobia	224756|Methanomicrobia	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	1.5.7.2,1.5.98.3	ko:K22162	-	-	-	-	ko00000,ko01000	3.D.9.1	-	-	FrhB_FdhB_C,FrhB_FdhB_N
SRR25158203_k127_4594645_7	269797.Mbar_A0256	1.313e-70	244.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,2N9N1@224756|Methanomicrobia	224756|Methanomicrobia	F	cytidyltransferase-related domain	nadR	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
SRR25158203_k127_4594645_3	192952.MM_1504	1.496e-90	304.0	COG0106@1|root,arCOG00618@2157|Archaea,2XSUF@28890|Euryarchaeota,2N949@224756|Methanomicrobia	224756|Methanomicrobia	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
SRR25158203_k127_4594645_6	269797.Mbar_A1338	1.571e-73	251.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2N9GR@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SRR25158203_k127_4594645_10	269797.Mbar_A0625	6.745e-46	171.0	COG2242@1|root,arCOG00977@2157|Archaea,2XVKZ@28890|Euryarchaeota,2N9SF@224756|Methanomicrobia	224756|Methanomicrobia	Q	Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7	cbiT	-	2.1.1.196	ko:K02191	ko00860,map00860	-	R05813,R07774	RC00003,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	Methyltransf_18,Methyltransf_25,Methyltransf_31
SRR25158203_k127_4594645_8	192952.MM_0999	3.708e-67	245.0	COG2243@1|root,arCOG00648@2157|Archaea,2XTS5@28890|Euryarchaeota,2N9NT@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
SRR25158203_k127_4594645_2	1094980.Mpsy_2057	6.105e-93	321.0	COG2875@1|root,arCOG00645@2157|Archaea,2XSZA@28890|Euryarchaeota,2N9G2@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0627	TP_methylase
SRR25158203_k127_4594645_9	1094980.Mpsy_2058	5.739e-48	183.0	COG2073@1|root,arCOG00651@2157|Archaea,2XTVD@28890|Euryarchaeota,2N9TZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM cobalamin (vitamin B12) biosynthesis CbiG protein	-	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N
SRR25158203_k127_4594645_1	269797.Mbar_A0629	6.69e-96	321.0	COG1010@1|root,arCOG00647@2157|Archaea,2XT45@28890|Euryarchaeota,2N9B8@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.131	ko:K05934	ko00860,ko01100,map00860,map01100	-	R05180,R05809	RC00003,RC01293,RC03471	ko00000,ko00001,ko01000	-	-	-	TP_methylase
SRR25158203_k127_4594645_5	1094980.Mpsy_2061	3.372e-74	254.0	COG2082@1|root,arCOG02247@2157|Archaea,2XT0S@28890|Euryarchaeota,2N9MJ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Precorrin-8X methylmutase CbiC CobH	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0630	CbiC
SRR25158203_k127_4594645_13	632335.Calkr_1119	1.09e-07	57.0	COG1669@1|root,COG1669@2|Bacteria,1VA30@1239|Firmicutes,24N71@186801|Clostridia	186801|Clostridia	L	PFAM DNA polymerase, beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
SRR25158203_k127_4594645_11	795359.TOPB45_0150	7.405e-45	166.0	COG2445@1|root,COG2445@2|Bacteria,2GIQZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Nucleotidyltransferase substrate binding protein like	-	-	-	-	-	-	-	-	-	-	-	-	NTase_sub_bind
SRR25158203_k127_4594645_0	192952.MM_2499	1.904e-147	476.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,2N99C@224756|Methanomicrobia	224756|Methanomicrobia	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	bchP	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3
SRR25158203_k127_4594645_12	1094980.Mpsy_2555	2.856e-25	105.0	COG1145@1|root,arCOG00958@2157|Archaea,2Y1CC@28890|Euryarchaeota,2NA30@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SRR25158203_k127_4596861_3	1094980.Mpsy_1243	5.33e-08	54.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
SRR25158203_k127_4596861_4	1173263.Syn7502_01204	8.115e-07	52.0	COG0467@1|root,COG0467@2|Bacteria,1G0KY@1117|Cyanobacteria,1GZB7@1129|Synechococcus	1117|Cyanobacteria	F	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SRR25158203_k127_4596861_2	316067.Geob_3569	1.775e-09	61.0	COG4251@1|root,COG4251@2|Bacteria,1N1KJ@1224|Proteobacteria,42W7E@68525|delta/epsilon subdivisions,2WSCW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
SRR25158203_k127_4596861_1	316067.Geob_3568	1.8e-32	129.0	COG4251@1|root,COG4251@2|Bacteria,1N44A@1224|Proteobacteria,431XF@68525|delta/epsilon subdivisions,2WWPK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	KaiB	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
SRR25158203_k127_4596861_0	1173027.Mic7113_1195	9.589e-192	619.0	COG0784@1|root,COG3437@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1H8US@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
SRR25158203_k127_4600706_6	1123326.JFBL01000009_gene805	6.68e-30	121.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,42NWV@68525|delta/epsilon subdivisions,2YMN9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K17051	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	Fer4_11
SRR25158203_k127_4600706_0	640081.Dsui_0149	1.891e-272	865.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,2KZX6@206389|Rhodocyclales	206389|Rhodocyclales	C	Molydopterin dinucleotide binding domain	-	-	-	ko:K17050	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	Molybdopterin,Molydop_binding
SRR25158203_k127_4600706_11	1306947.ARQD01000001_gene797	0.0009726	42.0	2F2TP@1|root,33VPS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4600706_7	1519464.HY22_00075	4.662e-24	114.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1FEZK@1090|Chlorobi	1090|Chlorobi	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
SRR25158203_k127_4600706_8	1499967.BAYZ01000102_gene3561	1.192e-11	70.0	COG4262@1|root,COG4262@2|Bacteria,2NS3W@2323|unclassified Bacteria	2|Bacteria	S	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_1,Spermine_synth
SRR25158203_k127_4600706_2	368407.Memar_0914	8.143e-88	297.0	COG0412@1|root,arCOG01659@2157|Archaea,2XZUN@28890|Euryarchaeota	28890|Euryarchaeota	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH,Peptidase_S9
SRR25158203_k127_4600706_9	662479.C440_02688	6.218e-06	55.0	COG2512@1|root,arCOG00386@2157|Archaea,2XZKM@28890|Euryarchaeota,23W4D@183963|Halobacteria	183963|Halobacteria	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
SRR25158203_k127_4600706_4	579137.Metvu_0844	3.891e-79	274.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,23QJ2@183939|Methanococci	183939|Methanococci	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
SRR25158203_k127_4600706_10	1121289.JHVL01000026_gene206	1.579e-05	49.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,36ETV@31979|Clostridiaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	macB1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SRR25158203_k127_4600706_1	1094980.Mpsy_1251	3.647e-133	444.0	COG0642@1|root,arCOG02362@1|root,arCOG02358@2157|Archaea,arCOG02362@2157|Archaea,2XVY8@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,sCache_3_3
SRR25158203_k127_4600706_3	304371.MCP_2267	2.558e-86	292.0	COG1701@1|root,arCOG04262@2157|Archaea,2XTAP@28890|Euryarchaeota,2N9DE@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF137	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
SRR25158203_k127_4600706_5	1041930.Mtc_0041	3.729e-71	250.0	COG1829@1|root,arCOG04263@2157|Archaea,2XST6@28890|Euryarchaeota,2N9J3@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GHMP kinase	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A3255	GHMP_kinases_N
SRR25158203_k127_4607112_5	521098.Aaci_0860	9.552e-50	182.0	COG1119@1|root,COG1119@2|Bacteria,1TRR4@1239|Firmicutes,4HB4U@91061|Bacilli	91061|Bacilli	P	abc transporter atp-binding protein	ylmA3	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
SRR25158203_k127_4607112_6	646529.Desaci_1338	1.334e-37	146.0	COG2259@1|root,COG2259@2|Bacteria,1V4UI@1239|Firmicutes	1239|Firmicutes	S	'oxidoreductase	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
SRR25158203_k127_4607112_12	871968.DESME_02915	3.745e-05	46.0	28ZH9@1|root,2ZM8R@2|Bacteria,1W1QQ@1239|Firmicutes,254P2@186801|Clostridia,266IH@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4607112_8	748449.Halha_2581	9.095e-21	97.0	COG1733@1|root,COG1733@2|Bacteria,1VBI7@1239|Firmicutes,24K21@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
SRR25158203_k127_4607112_3	192952.MM_1712	1.246e-150	484.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,2N90S@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
SRR25158203_k127_4607112_0	1094980.Mpsy_1453	3.459e-248	775.0	COG0016@1|root,arCOG00411@2157|Archaea,2XUJD@28890|Euryarchaeota,2N9CX@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys)	sepS	-	6.1.1.27	ko:K07587	ko00970,map00970	M00360	R08576	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
SRR25158203_k127_4607112_4	192952.MM_2362	3.381e-106	351.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,2N96J@224756|Methanomicrobia	224756|Methanomicrobia	E	shikimate kinase activity	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3127	GHMP_kinases_N
SRR25158203_k127_4607112_7	1094980.Mpsy_2765	1.741e-24	105.0	COG1605@1|root,arCOG02098@2157|Archaea,2Y6AQ@28890|Euryarchaeota,2N9YR@224756|Methanomicrobia	224756|Methanomicrobia	E	chorismate mutase	aroQ	-	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
SRR25158203_k127_4607112_2	192952.MM_2556	7.915e-176	559.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota,2N99K@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
SRR25158203_k127_4607112_1	1094980.Mpsy_1857	7.836e-225	712.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2N924@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM PilT protein domain protein	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
SRR25158203_k127_4607112_10	797209.ZOD2009_09580	1.226e-09	64.0	COG0640@1|root,arCOG03065@2157|Archaea,2XX2N@28890|Euryarchaeota,23VTM@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SRR25158203_k127_4637762_13	247490.KSU1_D0212	2.696e-19	99.0	COG3012@1|root,COG3012@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07039,ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	DUF1186,Peptidase_M90,SEC-C
SRR25158203_k127_4637762_0	1047013.AQSP01000121_gene2710	0.0	1319.0	COG0610@1|root,COG0610@2|Bacteria,2NNNC@2323|unclassified Bacteria	2|Bacteria	V	Subunit R is required for both nuclease and ATPase activities, but not for modification	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
SRR25158203_k127_4637762_11	386456.JQKN01000001_gene1902	1.824e-51	188.0	COG1451@1|root,arCOG02625@2157|Archaea,2Y0AZ@28890|Euryarchaeota,23P96@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
SRR25158203_k127_4637762_5	877455.Metbo_0714	9.345e-125	415.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota	28890|Euryarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
SRR25158203_k127_4637762_8	1094980.Mpsy_1814	1.072e-93	314.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
SRR25158203_k127_4637762_2	1094980.Mpsy_1815	2.875e-167	535.0	COG0422@1|root,arCOG02741@2157|Archaea,2Y2NF@28890|Euryarchaeota,2NAHH@224756|Methanomicrobia	224756|Methanomicrobia	H	Radical SAM ThiC family	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
SRR25158203_k127_4637762_6	192952.MM_0438	4.742e-96	322.0	COG0685@1|root,arCOG00475@2157|Archaea,2XZYB@28890|Euryarchaeota,2NACU@224756|Methanomicrobia	224756|Methanomicrobia	E	Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
SRR25158203_k127_4637762_10	1094980.Mpsy_1817	1.209e-62	222.0	arCOG04986@1|root,arCOG04986@2157|Archaea,2Y2BY@28890|Euryarchaeota,2NAAB@224756|Methanomicrobia	224756|Methanomicrobia	S	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
SRR25158203_k127_4637762_4	1094980.Mpsy_1818	1.263e-149	483.0	COG0294@1|root,arCOG02817@2157|Archaea,2XTHA@28890|Euryarchaeota,2NBNY@224756|Methanomicrobia	224756|Methanomicrobia	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
SRR25158203_k127_4637762_7	269797.Mbar_A1749	1.135e-95	319.0	COG3359@1|root,arCOG03130@2157|Archaea,2XUES@28890|Euryarchaeota,2NANN@224756|Methanomicrobia	224756|Methanomicrobia	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
SRR25158203_k127_4637762_3	1094980.Mpsy_1726	7.882e-162	522.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
SRR25158203_k127_4637762_9	269797.Mbar_A1004	4.048e-73	250.0	COG0681@1|root,arCOG01739@2157|Archaea,2XU45@28890|Euryarchaeota,2N9SB@224756|Methanomicrobia	224756|Methanomicrobia	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
SRR25158203_k127_4637762_1	1094980.Mpsy_1728	1.832e-182	580.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,2N983@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
SRR25158203_k127_4637762_12	304371.MCP_0019	1.314e-28	116.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,2N9Y5@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
SRR25158203_k127_463951_1	555088.DealDRAFT_1378	9.482e-72	252.0	COG2221@1|root,COG2221@2|Bacteria,1TR7P@1239|Firmicutes,2493K@186801|Clostridia	186801|Clostridia	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
SRR25158203_k127_463951_3	1094980.Mpsy_2264	5.643e-23	100.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
SRR25158203_k127_463951_4	192952.MM_1357	6.08e-20	91.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota,2NA53@224756|Methanomicrobia	224756|Methanomicrobia	S	TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
SRR25158203_k127_463951_2	635013.TherJR_2548	5.263e-51	188.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,261RD@186807|Peptococcaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
SRR25158203_k127_463951_0	1123368.AUIS01000010_gene2358	1.526e-107	356.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,1RNCW@1236|Gammaproteobacteria,2NBRS@225057|Acidithiobacillales	225057|Acidithiobacillales	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
SRR25158203_k127_4650573_11	192952.MM_1746	6.889e-32	125.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,2N98G@224756|Methanomicrobia	224756|Methanomicrobia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
SRR25158203_k127_4650573_3	192952.MM_1745	6.444e-118	385.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
SRR25158203_k127_4650573_9	368407.Memar_2053	5.163e-46	170.0	COG1714@1|root,arCOG03633@2157|Archaea,2XYB1@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
SRR25158203_k127_4650573_2	1178540.BA70_18720	6.676e-130	436.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,4H9QH@91061|Bacilli,1ZBY1@1386|Bacillus	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
SRR25158203_k127_4650573_7	1094980.Mpsy_1251	6.197e-66	247.0	COG0642@1|root,arCOG02362@1|root,arCOG02358@2157|Archaea,arCOG02362@2157|Archaea,2XVY8@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg,sCache_3_3
SRR25158203_k127_4650573_6	224325.AF_0640	2.437e-77	271.0	COG0715@1|root,arCOG01803@2157|Archaea,2Y7DP@28890|Euryarchaeota,246X9@183980|Archaeoglobi	183980|Archaeoglobi	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
SRR25158203_k127_4650573_0	635013.TherJR_2732	0.0	1289.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,260NC@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
SRR25158203_k127_4650573_8	1094980.Mpsy_1454	1.146e-59	214.0	COG1515@1|root,arCOG00929@2157|Archaea,2XURE@28890|Euryarchaeota,2N9UV@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
SRR25158203_k127_4650573_10	1094980.Mpsy_1348	3.922e-45	169.0	COG0778@1|root,arCOG00288@2157|Archaea,2XYAZ@28890|Euryarchaeota,2N9WV@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRR25158203_k127_4650573_5	573064.Mefer_0985	3.666e-81	275.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,23QIT@183939|Methanococci	183939|Methanococci	O	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
SRR25158203_k127_4650573_1	1071073.KI530537_gene2188	3.221e-141	458.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,4HAH3@91061|Bacilli,1ZAUZ@1386|Bacillus	91061|Bacilli	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SRR25158203_k127_4650573_4	1071073.KI530537_gene2189	3.654e-108	361.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,4HD08@91061|Bacilli,1ZPZV@1386|Bacillus	91061|Bacilli	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SRR25158203_k127_4662469_2	1094980.Mpsy_1324	2.585e-27	114.0	COG0721@1|root,arCOG02726@2157|Archaea,2XYQ0@28890|Euryarchaeota,2N9Z4@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
SRR25158203_k127_4662469_0	1094980.Mpsy_1325	9.61e-230	718.0	COG0154@1|root,arCOG01717@2157|Archaea,2XTV3@28890|Euryarchaeota,2N94U@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
SRR25158203_k127_4662469_1	1094980.Mpsy_1326	1.514e-221	695.0	COG0064@1|root,arCOG01718@2157|Archaea,2XSV3@28890|Euryarchaeota,2N981@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
SRR25158203_k127_4672079_2	247490.KSU1_D0308	8.42e-38	147.0	COG5061@1|root,COG5061@2|Bacteria	2|Bacteria	OU	protein folding in endoplasmic reticulum	satE	-	-	ko:K19134	-	-	-	-	ko00000,ko02048	-	-	-	DUF3307
SRR25158203_k127_4672079_1	247490.KSU1_D0309	2.463e-62	222.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
SRR25158203_k127_4672079_0	351160.RCIX2387	1.015e-195	631.0	COG0651@1|root,arCOG01537@2157|Archaea,2Y85B@28890|Euryarchaeota,2NAGR@224756|Methanomicrobia	224756|Methanomicrobia	C	plastoquinone (Complex I)	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
SRR25158203_k127_4673784_7	56780.SYN_02040	2.674e-62	222.0	COG0177@1|root,COG0177@2|Bacteria,1N2HB@1224|Proteobacteria,430KB@68525|delta/epsilon subdivisions,2WW2A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4673784_3	192952.MM_0663	6.941e-115	376.0	COG0543@1|root,arCOG02199@2157|Archaea,2XTVJ@28890|Euryarchaeota,2N9F0@224756|Methanomicrobia	224756|Methanomicrobia	C	Sulfide dehydrogenase (Flavoprotein) subunit SudB	-	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K02823	ko00240,ko01100,map00240,map01100	-	R10159	-	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
SRR25158203_k127_4673784_0	192952.MM_0664	1.88e-199	631.0	COG0493@1|root,arCOG01292@2157|Archaea,2XVPT@28890|Euryarchaeota,2N9A1@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
SRR25158203_k127_4673784_4	269797.Mbar_A3053	9.566e-102	335.0	COG5423@1|root,arCOG04361@2157|Archaea,2Y0Z3@28890|Euryarchaeota,2NBIT@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
SRR25158203_k127_4673784_9	1094980.Mpsy_3089	2.201e-08	66.0	arCOG02538@1|root,arCOG03257@1|root,arCOG02538@2157|Archaea,arCOG03257@2157|Archaea	2157|Archaea	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,PKD,PQQ_3,Peptidase_S8,S-layer
SRR25158203_k127_4673784_5	1121472.AQWN01000002_gene2159	3.344e-79	269.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,260FH@186807|Peptococcaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SRR25158203_k127_4673784_8	192952.MM_2504	3.23e-58	209.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,2N95Q@224756|Methanomicrobia	224756|Methanomicrobia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SRR25158203_k127_4673784_1	1094980.Mpsy_0984	6.487e-156	497.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota,2NBNX@224756|Methanomicrobia	224756|Methanomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	gcp	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
SRR25158203_k127_4673784_6	269797.Mbar_A0279	1.798e-69	241.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,2N9B7@224756|Methanomicrobia	224756|Methanomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,RIO1
SRR25158203_k127_4673784_2	269797.Mbar_A0082	5.263e-129	419.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
SRR25158203_k127_4674627_9	386456.JQKN01000002_gene2525	8.684e-09	56.0	COG1669@1|root,arCOG01206@2157|Archaea,2Y02Z@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_4674627_4	102125.Xen7305DRAFT_00053960	1.374e-31	126.0	COG2361@1|root,COG2361@2|Bacteria,1G9J5@1117|Cyanobacteria,3VKQ2@52604|Pleurocapsales	1117|Cyanobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
SRR25158203_k127_4674627_2	877455.Metbo_1697	6.709e-47	181.0	arCOG01744@1|root,arCOG01744@2157|Archaea,2Y62D@28890|Euryarchaeota	28890|Euryarchaeota	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
SRR25158203_k127_4674627_1	1121423.JONT01000003_gene977	3.197e-84	293.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,24ANY@186801|Clostridia,26317@186807|Peptococcaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
SRR25158203_k127_4674627_0	1094980.Mpsy_3119	1.996e-142	461.0	COG2133@1|root,arCOG02796@2157|Archaea,2Y6WR@28890|Euryarchaeota,2NACH@224756|Methanomicrobia	224756|Methanomicrobia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
SRR25158203_k127_4674627_6	1094980.Mpsy_2335	4.187e-19	88.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,2N9FQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
SRR25158203_k127_4674627_3	192952.MM_1393	3.109e-40	153.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,2N9FQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
SRR25158203_k127_4674627_10	591019.Shell_0819	2.515e-06	53.0	COG2896@1|root,arCOG00930@2157|Archaea,2XQAC@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
SRR25158203_k127_4674627_8	387631.Asulf_01670	3.218e-17	84.0	COG1826@1|root,arCOG02694@2157|Archaea,2XZZ6@28890|Euryarchaeota,246CG@183980|Archaeoglobi	183980|Archaeoglobi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SRR25158203_k127_4674627_5	76114.c1A60	2.173e-26	117.0	COG3381@1|root,COG3381@2|Bacteria,1RAXF@1224|Proteobacteria,2VY6I@28216|Betaproteobacteria,2KXH2@206389|Rhodocyclales	206389|Rhodocyclales	S	Nitrate reductase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
SRR25158203_k127_4674627_7	698757.Pogu_1851	4.069e-18	93.0	arCOG04198@1|root,arCOG04198@2157|Archaea	2157|Archaea	S	Ethylbenzene dehydrogenase	-	-	-	ko:K17052	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	EB_dh
SRR25158203_k127_4680727_14	269797.Mbar_A1775	1.179e-07	63.0	arCOG03257@1|root,arCOG03257@2157|Archaea	2157|Archaea	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
SRR25158203_k127_4680727_1	926550.CLDAP_18170	4.489e-141	460.0	COG1252@1|root,COG1252@2|Bacteria,2G5SS@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SRR25158203_k127_4680727_6	483219.LILAB_16360	3.46e-77	265.0	COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,43BAG@68525|delta/epsilon subdivisions,2X6PP@28221|Deltaproteobacteria,2YUZG@29|Myxococcales	28221|Deltaproteobacteria	H	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
SRR25158203_k127_4680727_12	269797.Mbar_A3470	3.056e-44	166.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,2NA00@224756|Methanomicrobia	224756|Methanomicrobia	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
SRR25158203_k127_4680727_5	926561.KB900617_gene2016	2.675e-100	336.0	COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,248J4@186801|Clostridia	186801|Clostridia	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
SRR25158203_k127_4680727_9	760568.Desku_2247	1.844e-55	203.0	COG1424@1|root,COG1424@2|Bacteria	2|Bacteria	H	6-carboxyhexanoate-CoA ligase activity	bioW	-	2.3.1.47,6.2.1.14	ko:K00652,ko:K01906	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03209,R03210,R10124	RC00004,RC00014,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,BioW
SRR25158203_k127_4680727_4	306281.AJLK01000019_gene3738	3.344e-107	357.0	COG1748@1|root,COG1748@2|Bacteria,1G0N9@1117|Cyanobacteria,1JIBD@1189|Stigonemataceae	1117|Cyanobacteria	E	PFAM Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ELFV_dehydrog
SRR25158203_k127_4680727_3	760568.Desku_2246	5.351e-124	409.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,261UX@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47,6.2.1.14	ko:K00639,ko:K00652,ko:K01906	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03209,R03210,R10124	RC00004,RC00014,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,BioW
SRR25158203_k127_4680727_7	1121422.AUMW01000023_gene2749	1.209e-62	222.0	COG0132@1|root,COG0132@2|Bacteria,1UYA3@1239|Firmicutes,24F15@186801|Clostridia,26262@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
SRR25158203_k127_4680727_10	573064.Mefer_1527	1.463e-51	190.0	COG1268@1|root,arCOG02986@2157|Archaea,2XWSG@28890|Euryarchaeota	28890|Euryarchaeota	S	BioY protein	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
SRR25158203_k127_4680727_15	700598.Niako_3241	2.615e-05	54.0	COG3391@1|root,COG3391@2|Bacteria,4NNEF@976|Bacteroidetes,1IR2D@117747|Sphingobacteriia	976|Bacteroidetes	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA,NHL,TIG
SRR25158203_k127_4680727_8	395495.Lcho_2630	1.105e-58	222.0	COG4733@1|root,COG4733@2|Bacteria,1QZYI@1224|Proteobacteria,2VXAJ@28216|Betaproteobacteria,1KNYU@119065|unclassified Burkholderiales	2|Bacteria	S	PFAM Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Malectin,PA14,fn3
SRR25158203_k127_4680727_13	443255.SCLAV_p1431	4.535e-11	76.0	COG1361@1|root,COG3391@1|root,COG1361@2|Bacteria,COG3391@2|Bacteria,2GK45@201174|Actinobacteria	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Lactonase,TIG
SRR25158203_k127_4680727_0	545243.BAEV01000013_gene1017	1.163e-192	660.0	COG2132@1|root,COG2132@2|Bacteria,1URD7@1239|Firmicutes,249RP@186801|Clostridia,36GN8@31979|Clostridiaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22349	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_3
SRR25158203_k127_4680727_2	1232410.KI421412_gene439	8.175e-139	460.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42XHS@68525|delta/epsilon subdivisions,2WTFP@28221|Deltaproteobacteria,43VUE@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
SRR25158203_k127_4680727_11	1347086.CCBA010000003_gene3822	5.18e-46	169.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
SRR25158203_k127_4681049_2	748449.Halha_2390	4.525e-08	64.0	COG3206@1|root,COG3206@2|Bacteria,1VISC@1239|Firmicutes,24SWS@186801|Clostridia,3WBSG@53433|Halanaerobiales	186801|Clostridia	M	PFAM Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
SRR25158203_k127_4681049_0	1198232.CYCME_0277	6.517e-18	87.0	COG5652@1|root,COG5652@2|Bacteria,1NB26@1224|Proteobacteria,1SHZK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
SRR25158203_k127_4681049_1	387631.Asulf_00018	1.109e-17	86.0	2BVY9@1|root,2N553@2157|Archaea,2Y1ZH@28890|Euryarchaeota,246I9@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4682071_2	269797.Mbar_A1192	1.424e-72	248.0	COG0496@1|root,arCOG02303@2157|Archaea,2XT5R@28890|Euryarchaeota,2N9DM@224756|Methanomicrobia	224756|Methanomicrobia	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1192	SurE
SRR25158203_k127_4682071_0	1094980.Mpsy_1478	6.118e-170	544.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,2N9BT@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
SRR25158203_k127_4682071_3	1041930.Mtc_0663	1.059e-70	246.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4682071_1	192952.MM_2378	7.998e-101	340.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,2N948@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
SRR25158203_k127_4682071_4	1459636.NTE_02255	3.352e-15	81.0	COG1238@1|root,arCOG03118@2157|Archaea	2157|Archaea	I	SNARE associated Golgi protein	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
SRR25158203_k127_4689345_4	269797.Mbar_A3236	3.502e-82	280.0	COG1018@1|root,arCOG02200@2157|Archaea,2XVD3@28890|Euryarchaeota,2N9JH@224756|Methanomicrobia	224756|Methanomicrobia	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
SRR25158203_k127_4689345_2	118163.Ple7327_4018	6.691e-105	349.0	COG1752@1|root,COG1752@2|Bacteria,1G2F8@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
SRR25158203_k127_4689345_6	760568.Desku_0333	1.999e-70	249.0	COG1250@1|root,COG1250@2|Bacteria,1TPA4@1239|Firmicutes,24DBH@186801|Clostridia,263NE@186807|Peptococcaceae	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
SRR25158203_k127_4689345_1	1459636.NTE_03144	7.093e-113	372.0	COG0604@1|root,arCOG01458@2157|Archaea	2157|Archaea	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
SRR25158203_k127_4689345_10	351160.RRC294	3.162e-21	95.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0FK@28890|Euryarchaeota,2N9YX@224756|Methanomicrobia	224756|Methanomicrobia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
SRR25158203_k127_4689345_7	351160.RRC295	2.743e-46	169.0	COG4802@1|root,arCOG01099@2157|Archaea	2157|Archaea	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422,FeThRed_B,Glutaredoxin
SRR25158203_k127_4689345_9	351160.RRC297	1.443e-28	120.0	COG2146@1|root,arCOG02854@2157|Archaea	2157|Archaea	C	PFAM Rieske 2Fe-2S domain	sdx	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	DAO,Rieske
SRR25158203_k127_4689345_3	1183438.GKIL_3325	8.336e-91	312.0	COG2133@1|root,COG2133@2|Bacteria,1G5E2@1117|Cyanobacteria	1117|Cyanobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
SRR25158203_k127_4689345_0	1107311.Q767_10515	1.255e-131	429.0	COG1565@1|root,COG1565@2|Bacteria,4PD08@976|Bacteroidetes,1IDI8@117743|Flavobacteriia,2NYHP@237|Flavobacterium	976|Bacteroidetes	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
SRR25158203_k127_4689345_12	368407.Memar_2323	4.248e-11	67.0	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota,2NBAW@224756|Methanomicrobia	224756|Methanomicrobia	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
SRR25158203_k127_4689345_5	192952.MM_0895	4.242e-75	257.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,2N9S3@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
SRR25158203_k127_4689345_11	1446473.JHWH01000009_gene242	2.865e-12	67.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,2PVWT@265|Paracoccus	28211|Alphaproteobacteria	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
SRR25158203_k127_4693512_0	1094980.Mpsy_2699	1.266e-163	524.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,2N9BW@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SRR25158203_k127_4693512_1	269797.Mbar_A0220	1.176e-156	499.0	COG0059@1|root,arCOG04465@2157|Archaea,2XTGU@28890|Euryarchaeota,2N98K@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
SRR25158203_k127_4693512_7	1041930.Mtc_0432	6.093e-57	204.0	arCOG03443@1|root,arCOG03443@2157|Archaea,2Y0YU@28890|Euryarchaeota	28890|Euryarchaeota	S	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RLAN
SRR25158203_k127_4693512_3	351160.RCIX1055	1.991e-112	369.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT55@28890|Euryarchaeota,2NA3R@224756|Methanomicrobia	224756|Methanomicrobia	H	RimK-like ATP-grasp domain	rimK	-	-	-	-	-	-	-	-	-	-	-	RimK
SRR25158203_k127_4693512_16	1235803.C825_05443	1.999e-22	102.0	COG0454@1|root,COG0456@2|Bacteria,4NVA5@976|Bacteroidetes,2FT3B@200643|Bacteroidia	976|Bacteroidetes	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRR25158203_k127_4693512_11	269797.Mbar_A1096	1.424e-35	139.0	COG4048@1|root,arCOG04902@2157|Archaea,2Y8FE@28890|Euryarchaeota,2N9Y6@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2111)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2111
SRR25158203_k127_4693512_22	1210908.HSB1_04810	3.136e-08	61.0	COG0589@1|root,arCOG02053@2157|Archaea,2XXRS@28890|Euryarchaeota,23W7D@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SRR25158203_k127_4693512_15	1094980.Mpsy_2166	7.397e-23	100.0	arCOG03354@1|root,arCOG03353@2157|Archaea,2Y3N8@28890|Euryarchaeota,2NAX4@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1699)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1699
SRR25158203_k127_4693512_8	1094980.Mpsy_2771	9.651e-56	202.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,2N9RR@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM methyltransferase small	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
SRR25158203_k127_4693512_23	269799.Gmet_0909	0.000326	52.0	COG3303@1|root,COG3303@2|Bacteria,1MYBV@1224|Proteobacteria,42SER@68525|delta/epsilon subdivisions,2WPC2@28221|Deltaproteobacteria,43UYR@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
SRR25158203_k127_4693512_9	671143.DAMO_0826	5.549e-50	192.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	ko:K02569,ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrome_C7
SRR25158203_k127_4693512_21	945713.IALB_1306	3.927e-09	68.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
SRR25158203_k127_4693512_2	589924.Ferp_0646	1.771e-114	381.0	COG5557@1|root,arCOG02025@2157|Archaea,2XWFI@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
SRR25158203_k127_4693512_4	589924.Ferp_1438	1.947e-97	325.0	COG0437@1|root,arCOG01500@2157|Archaea,2XXPU@28890|Euryarchaeota,24691@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4,Fer4_11
SRR25158203_k127_4693512_12	589924.Ferp_1439	9.188e-32	129.0	arCOG12382@1|root,arCOG12382@2157|Archaea,2Y3JR@28890|Euryarchaeota,2470X@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4693512_18	443144.GM21_3175	3.672e-14	83.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
SRR25158203_k127_4693512_6	192952.MM_2433	1.303e-75	259.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,2N9HT@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
SRR25158203_k127_4693512_5	572546.Arcpr_1811	3.966e-82	283.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,245QE@183980|Archaeoglobi	183980|Archaeoglobi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SRR25158203_k127_4693512_14	565033.GACE_0402	1.224e-24	107.0	COG4738@1|root,arCOG04377@2157|Archaea,2XYIC@28890|Euryarchaeota,246AV@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_4693512_19	1031288.AXAA01000006_gene1124	6.014e-12	66.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,36MNT@31979|Clostridiaceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
SRR25158203_k127_4693512_24	573063.Metin_0799	0.0004874	46.0	COG1923@1|root,arCOG08275@2157|Archaea	2157|Archaea	S	Hfq protein	-	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
SRR25158203_k127_4693512_20	1365176.N186_01195	1.578e-11	70.0	COG0863@1|root,arCOG00129@2157|Archaea,2XPT8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA methylase N-4 N-6 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
SRR25158203_k127_4693512_17	309799.DICTH_1800	4.593e-15	76.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
SRR25158203_k127_4693512_13	572546.Arcpr_0113	7.136e-27	111.0	arCOG11129@1|root,arCOG11129@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4258
SRR25158203_k127_4693512_10	309799.DICTH_1800	1.742e-43	162.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
SRR25158203_k127_494113_14	573064.Mefer_0959	2.511e-11	64.0	COG1123@1|root,arCOG00185@2157|Archaea,2XVG9@28890|Euryarchaeota,23QB2@183939|Methanococci	183939|Methanococci	E	PFAM ABC transporter related	-	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
SRR25158203_k127_494113_2	192952.MM_0866	4.273e-98	329.0	COG0616@1|root,arCOG01311@2157|Archaea,2XTG8@28890|Euryarchaeota,2N9DH@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM signal peptide peptidase SppA, 36K type	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
SRR25158203_k127_494113_5	192952.MM_1593	3.57e-76	265.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,2N9S7@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
SRR25158203_k127_494113_0	673860.AciM339_1039	1.561e-169	541.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,3F2G3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.114,4.2.1.33,4.2.1.35	ko:K01703,ko:K16792	ko00290,ko00300,ko00660,ko00680,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00680,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00432,M00433,M00535,M00608	R03444,R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R09720,R10170,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
SRR25158203_k127_494113_7	439481.Aboo_1465	7.362e-68	233.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,3F2QD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
SRR25158203_k127_494113_8	273075.Ta0577	3.603e-57	216.0	COG0665@1|root,arCOG00755@2157|Archaea,2Y66F@28890|Euryarchaeota,24239@183967|Thermoplasmata	183967|Thermoplasmata	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
SRR25158203_k127_494113_11	387631.Asulf_01832	2.746e-27	115.0	COG1487@1|root,arCOG02219@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
SRR25158203_k127_494113_4	192952.MM_3102	7.259e-84	287.0	arCOG03273@1|root,arCOG03276@2157|Archaea	192952.MM_3102|-	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_494113_3	386456.JQKN01000011_gene733	9.601e-97	330.0	COG1304@1|root,COG1773@1|root,arCOG00613@2157|Archaea,arCOG04391@2157|Archaea,2XTFQ@28890|Euryarchaeota	28890|Euryarchaeota	H	L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases	-	-	1.13.12.4	ko:K00467	ko00620,map00620	-	R00319	RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh,Rubredoxin
SRR25158203_k127_494113_15	224325.AF_2234	6.609e-08	57.0	arCOG03597@1|root,arCOG03597@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
SRR25158203_k127_494113_12	1343739.PAP_03330	4.218e-20	91.0	COG1773@1|root,arCOG04391@2157|Archaea,2Y080@28890|Euryarchaeota,244NA@183968|Thermococci	183968|Thermococci	C	Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
SRR25158203_k127_494113_1	997346.HMPREF9374_3157	1.62e-135	446.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4HB3K@91061|Bacilli,27BBA@186824|Thermoactinomycetaceae	91061|Bacilli	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRR25158203_k127_494113_10	36033.XP_001643375.1	2.265e-38	147.0	COG0320@1|root,KOG2672@2759|Eukaryota,38EBV@33154|Opisthokonta,3NWHD@4751|Fungi,3QMC3@4890|Ascomycota,3RTNV@4891|Saccharomycetes,3RZIR@4893|Saccharomycetaceae	4751|Fungi	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
SRR25158203_k127_494113_9	649638.Trad_2085	1.722e-54	195.0	COG0320@1|root,COG0320@2|Bacteria,1WIE7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
SRR25158203_k127_494113_6	247490.KSU1_C0935	8.117e-76	264.0	COG0450@1|root,COG0450@2|Bacteria,2IZ3M@203682|Planctomycetes	203682|Planctomycetes	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
SRR25158203_k127_494113_17	237368.SCABRO_00945	0.0009645	43.0	COG4634@1|root,COG4634@2|Bacteria,2J4DQ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_494113_16	572546.Arcpr_1174	0.0003431	49.0	COG2405@1|root,arCOG00719@2157|Archaea	2157|Archaea	K	nucleic acid-binding protein contains PIN domain	-	-	-	ko:K07066	-	-	-	-	ko00000	-	-	-	DUF3368
SRR25158203_k127_494113_13	1070774.J07HN4v3_03254	1.935e-11	68.0	COG2886@1|root,arCOG00722@2157|Archaea,2Y23X@28890|Euryarchaeota,23YWW@183963|Halobacteria	183963|Halobacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
SRR25158203_k127_506484_0	1094980.Mpsy_1799	1.85e-188	606.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,2N990@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
SRR25158203_k127_506484_1	444158.MmarC6_0270	9.266e-41	157.0	COG1082@1|root,arCOG01897@2157|Archaea,2XW6D@28890|Euryarchaeota,23QGW@183939|Methanococci	183939|Methanococci	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SRR25158203_k127_518488_4	1499967.BAYZ01000080_gene935	3.595e-76	271.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
SRR25158203_k127_518488_3	192952.MM_0872	2.554e-80	276.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,2N9HI@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SRR25158203_k127_518488_9	1469607.KK073768_gene1377	1.34e-14	76.0	COG4095@1|root,COG4095@2|Bacteria,1G9AI@1117|Cyanobacteria,1HPAD@1161|Nostocales	1117|Cyanobacteria	S	PQ loop repeat	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	MtN3_slv,PQ-loop
SRR25158203_k127_518488_1	269797.Mbar_A1493	6.991e-114	376.0	COG1903@1|root,arCOG04383@2157|Archaea,2XV53@28890|Euryarchaeota,2N9AY@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
SRR25158203_k127_518488_5	269797.Mbar_A1492	3.797e-63	222.0	COG2241@1|root,arCOG00650@2157|Archaea,2XZ22@28890|Euryarchaeota,2N9VQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit	cbiE	-	2.1.1.289	ko:K03399	ko00860,ko01100,map00860,map01100	-	R05813,R07775	RC00003,RC02052,RC02053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1492	TP_methylase
SRR25158203_k127_518488_7	192952.MM_1539	9.456e-29	131.0	arCOG03489@1|root,arCOG03489@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_518488_2	192952.MM_1854	1.935e-88	297.0	COG1036@1|root,arCOG01705@2157|Archaea,2XX7Y@28890|Euryarchaeota,2NAPS@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavoprotein	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0042558,GO:0042559,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901283,GO:1901285,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:2001115,GO:2001116,GO:2001117,GO:2001118	1.5.99.15	ko:K18853	ko00790,map00790	-	R10802	RC01584	ko00000,ko00001,ko01000	-	-	-	Fer4,Flavoprotein
SRR25158203_k127_518488_8	269797.Mbar_A3597	1.505e-27	113.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0FB@28890|Euryarchaeota,2NA05@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM
SRR25158203_k127_518488_6	304371.MCP_1416	6.367e-29	119.0	COG1522@1|root,arCOG04153@2157|Archaea,2XX2W@28890|Euryarchaeota,2N9ZN@224756|Methanomicrobia	224756|Methanomicrobia	K	B-block binding subunit of TFIIIC	-	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC
SRR25158203_k127_518488_0	1094980.Mpsy_1377	4.276e-118	386.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,2N93S@224756|Methanomicrobia	224756|Methanomicrobia	C	CoB--CoM heterodisulfide reductase subunit B	hdrB-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SRR25158203_k127_52583_9	1325130.HFN_1164	4.61e-09	58.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2YN1A@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Aminotransferase	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
SRR25158203_k127_52583_8	387631.Asulf_00149	4.323e-09	61.0	arCOG10388@1|root,arCOG10388@2157|Archaea,2Y57I@28890|Euryarchaeota,247FR@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_52583_5	1094980.Mpsy_1931	1.513e-15	85.0	arCOG02425@1|root,arCOG02425@2157|Archaea	2157|Archaea	S	Archaeal Type IV pilin, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
SRR25158203_k127_52583_6	1041930.Mtc_0168	3.226e-15	75.0	arCOG07976@1|root,arCOG07976@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_52583_2	224325.AF_1935	5.233e-136	439.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2460U@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT	mch	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
SRR25158203_k127_52583_4	351160.RCIX2192	9.113e-31	122.0	COG4746@1|root,arCOG02797@2157|Archaea,2Y6V4@28890|Euryarchaeota,2N9YW@224756|Methanomicrobia	224756|Methanomicrobia	S	MTH865-like family	-	-	-	-	-	-	-	-	-	-	-	-	MTH865
SRR25158203_k127_52583_1	867903.ThesuDRAFT_02319	1.205e-136	449.0	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRR25158203_k127_52583_0	1094980.Mpsy_2178	3.126e-196	621.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,2N91C@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
SRR25158203_k127_52583_3	269797.Mbar_A0973	5.949e-86	291.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,2N9NR@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SRR25158203_k127_52583_7	323259.Mhun_2372	1.368e-10	63.0	COG3466@1|root,arCOG03883@2157|Archaea	2157|Archaea	S	to GB L77117 SP Q57808 PID 1499149 percent identity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2080
SRR25158203_k127_526291_1	1094980.Mpsy_1669	2.09e-60	213.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,2N9C5@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SRR25158203_k127_526291_2	1094980.Mpsy_2209	1.234e-19	91.0	COG0695@1|root,arCOG02607@2157|Archaea,2XZVV@28890|Euryarchaeota,2N9Z7@224756|Methanomicrobia	224756|Methanomicrobia	O	COG3634 Alkyl hydroperoxide reductase, large subunit	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
SRR25158203_k127_526291_0	1094980.Mpsy_2210	9.643e-240	748.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
SRR25158203_k127_546789_4	192952.MM_2850	1.724e-28	128.0	COG4591@1|root,arCOG02313@2157|Archaea,2Y3AK@28890|Euryarchaeota,2NAK5@224756|Methanomicrobia	224756|Methanomicrobia	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
SRR25158203_k127_546789_3	323259.Mhun_1426	3.313e-36	152.0	COG0577@1|root,arCOG02315@2157|Archaea,2XYJU@28890|Euryarchaeota,2N9SS@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
SRR25158203_k127_546789_0	1410633.JHWR01000009_gene1908	5.113e-64	226.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,27J1B@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR25158203_k127_546789_6	368407.Memar_0458	2.757e-16	87.0	COG3413@1|root,arCOG02272@2157|Archaea	2157|Archaea	S	Bacterio-opsin activator HTH	-	-	1.5.1.40	ko:K06930,ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	BAT,HTH_10
SRR25158203_k127_546789_2	797299.HALLA_05575	4.309e-38	154.0	COG1378@1|root,arCOG02037@2157|Archaea,2XT5T@28890|Euryarchaeota,23SZB@183963|Halobacteria	183963|Halobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
SRR25158203_k127_546789_1	604354.TSIB_1847	2.017e-46	182.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,242W8@183968|Thermococci	183968|Thermococci	S	Patched family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SRR25158203_k127_546789_5	523850.TON_1626	8.579e-24	112.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,242W8@183968|Thermococci	183968|Thermococci	S	Patched family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
SRR25158203_k127_549051_6	1041930.Mtc_2393	2.7e-23	101.0	COG0004@1|root,arCOG04397@2157|Archaea,2XTEB@28890|Euryarchaeota,2N971@224756|Methanomicrobia	224756|Methanomicrobia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
SRR25158203_k127_549051_1	1094980.Mpsy_1157	8.398e-146	474.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,2N94Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
SRR25158203_k127_549051_4	1094980.Mpsy_2097	2.152e-77	281.0	COG0526@1|root,COG0785@1|root,arCOG01972@2157|Archaea,arCOG02404@2157|Archaea,2Y7HT@28890|Euryarchaeota,2NA19@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
SRR25158203_k127_549051_7	330214.NIDE0677	2.353e-13	79.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbA	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	iEcSMS35_1347.EcSMS35_4241	DSBA
SRR25158203_k127_549051_0	316067.Geob_1067	4.221e-199	634.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,42Z8C@68525|delta/epsilon subdivisions,2WU08@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_549051_3	351160.RCIX2142	7.207e-88	299.0	COG0083@1|root,arCOG01027@2157|Archaea,2XUDU@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SRR25158203_k127_549051_5	1379698.RBG1_1C00001G0068	6.472e-68	234.0	COG1839@1|root,COG1839@2|Bacteria,2NPAQ@2323|unclassified Bacteria	2|Bacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
SRR25158203_k127_549051_8	547559.Nmag_3421	1.459e-08	61.0	COG0640@1|root,arCOG03065@2157|Archaea,2XX2N@28890|Euryarchaeota,23VTM@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SRR25158203_k127_549051_2	1347086.CCBA010000003_gene3822	9.917e-136	441.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
SRR25158203_k127_560568_3	269797.Mbar_A3234	1.608e-14	74.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SRR25158203_k127_560568_0	192952.MM_0246	1.412e-148	479.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,2N9EM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
SRR25158203_k127_560568_2	485914.Hmuk_0677	2.569e-37	164.0	COG1520@1|root,arCOG02556@2157|Archaea,2Y7Q9@28890|Euryarchaeota,240XC@183963|Halobacteria	183963|Halobacteria	C	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
SRR25158203_k127_560568_1	192952.MM_2210	5.171e-96	351.0	COG1287@1|root,arCOG02043@2157|Archaea,2XX8Q@28890|Euryarchaeota,2NADZ@224756|Methanomicrobia	224756|Methanomicrobia	M	Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
SRR25158203_k127_592792_0	1041930.Mtc_2146	2.664e-311	961.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,2N96G@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SRR25158203_k127_592792_1	351160.LRC356	2.02e-303	940.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,2N93R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB2	-	2.7.7.6	ko:K03044	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SRR25158203_k127_592792_2	1094980.Mpsy_1006	4.989e-162	515.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU9Q@28890|Euryarchaeota,2N99Y@224756|Methanomicrobia	224756|Methanomicrobia	K	Belongs to the RNA polymerase beta chain family	rpoB1	-	2.7.7.6	ko:K03045	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3
SRR25158203_k127_598782_2	589924.Ferp_0670	3.188e-75	271.0	arCOG08705@1|root,arCOG08705@2157|Archaea	2157|Archaea	-	-	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	-
SRR25158203_k127_598782_4	192952.MM_0458	6.476e-49	179.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2N9RM@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM cytidyltransferase-related domain	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SRR25158203_k127_598782_0	269797.Mbar_A1507	1.675e-200	640.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,2N9FV@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
SRR25158203_k127_598782_1	529709.PYCH_07920	1.551e-90	307.0	COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota,243F1@183968|Thermococci	183968|Thermococci	E	Belongs to the carbamate kinase family	cpkA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SRR25158203_k127_598782_7	264732.Moth_2496	5.249e-18	85.0	COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,25JIA@186801|Clostridia,42HCF@68295|Thermoanaerobacterales	186801|Clostridia	D	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
SRR25158203_k127_598782_3	335541.Swol_1294	2.032e-55	199.0	COG5561@1|root,COG5561@2|Bacteria,1VBDY@1239|Firmicutes,25DZ2@186801|Clostridia	186801|Clostridia	S	Proto-chlorophyllide reductase 57 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	CGGC,PCP_red
SRR25158203_k127_598782_5	192952.MM_2652	3.051e-39	153.0	COG4090@1|root,arCOG04847@2157|Archaea,2Y0R9@28890|Euryarchaeota,2NA0W@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2124
SRR25158203_k127_598782_9	1197130.BAFM01000019_gene2764	0.0005852	48.0	arCOG01207@1|root,arCOG01207@2157|Archaea,2Y0YC@28890|Euryarchaeota,23XZ6@183963|Halobacteria	183963|Halobacteria	K	IclR helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR
SRR25158203_k127_598782_8	243090.RB9985	0.0003134	46.0	28JE3@1|root,2Z98B@2|Bacteria,2J0PD@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_598782_6	304371.MCP_0401	1.65e-29	118.0	COG0715@1|root,arCOG01803@2157|Archaea,2XWEK@28890|Euryarchaeota,2NAA1@224756|Methanomicrobia	224756|Methanomicrobia	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
SRR25158203_k127_619746_18	1124780.ANNU01000012_gene3922	1.443e-15	91.0	COG2766@1|root,COG2766@2|Bacteria	2|Bacteria	T	protein kinase activity	prkA	GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
SRR25158203_k127_619746_12	192952.MM_1628	3.194e-71	245.0	COG0717@1|root,arCOG04048@2157|Archaea,2XVHA@28890|Euryarchaeota,2NBIR@224756|Methanomicrobia	224756|Methanomicrobia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
SRR25158203_k127_619746_9	269797.Mbar_A1407	1.979e-88	305.0	COG3547@1|root,arCOG03585@2157|Archaea,2XWFH@28890|Euryarchaeota	28890|Euryarchaeota	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
SRR25158203_k127_619746_7	304371.MCP_1923	5.287e-96	323.0	COG2801@1|root,arCOG10339@2157|Archaea	2157|Archaea	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
SRR25158203_k127_619746_17	304371.MCP_1924	2.253e-19	91.0	COG2963@1|root,arCOG11984@2157|Archaea	2157|Archaea	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
SRR25158203_k127_619746_19	795359.TOPB45_1232	1.843e-09	59.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
SRR25158203_k127_619746_21	909663.KI867150_gene2869	3.359e-05	47.0	COG0006@1|root,COG0006@2|Bacteria,1QNPN@1224|Proteobacteria,431BA@68525|delta/epsilon subdivisions,2WW9X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
SRR25158203_k127_619746_5	479434.Sthe_1439	4.663e-127	412.0	COG0616@1|root,COG0616@2|Bacteria,2G635@200795|Chloroflexi,27XH7@189775|Thermomicrobia	189775|Thermomicrobia	OU	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
SRR25158203_k127_619746_10	931277.C448_07222	4.24e-82	286.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,23SH5@183963|Halobacteria	183963|Halobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SRR25158203_k127_619746_0	1094980.Mpsy_2937	5.569e-246	776.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,2N9BR@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
SRR25158203_k127_619746_8	269797.Mbar_A3283	4.686e-91	316.0	COG0696@1|root,arCOG04940@2157|Archaea,2XYF6@28890|Euryarchaeota,2N9RV@224756|Methanomicrobia	224756|Methanomicrobia	G	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
SRR25158203_k127_619746_11	192952.MM_1871	1.884e-73	251.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,2N9MQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
SRR25158203_k127_619746_2	269797.Mbar_A0716	3.535e-170	543.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,2N95C@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
SRR25158203_k127_619746_3	1094980.Mpsy_2252	1.979e-166	530.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,2N98R@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
SRR25158203_k127_619746_14	1094980.Mpsy_1858	4.274e-48	174.0	COG0139@1|root,arCOG02676@2157|Archaea,2XX3X@28890|Euryarchaeota,2N9QJ@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
SRR25158203_k127_619746_6	269797.Mbar_A2257	2.572e-119	398.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,2N9WJ@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM asparagine synthase	asnB-2	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
SRR25158203_k127_619746_13	1469607.KK073768_gene4650	2.652e-66	228.0	COG0590@1|root,COG0590@2|Bacteria,1G534@1117|Cyanobacteria,1HN36@1161|Nostocales	1117|Cyanobacteria	FJ	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	MafB19-deam,dCMP_cyt_deam_1
SRR25158203_k127_619746_4	192952.MM_0126	4.678e-141	460.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SRR25158203_k127_619746_1	269797.Mbar_A2101	1.53e-228	719.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota,2N9B0@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SRR25158203_k127_619746_15	880073.Calab_0709	9.296e-35	134.0	COG2378@1|root,COG2378@2|Bacteria	2|Bacteria	K	regulation of single-species biofilm formation	yfjR	GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_DeoR,WYL
SRR25158203_k127_619746_16	192952.MM_0832	4.125e-22	108.0	COG4745@1|root,arCOG00562@2157|Archaea,2XUNV@28890|Euryarchaeota,2NAWY@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
SRR25158203_k127_62709_2	589924.Ferp_0944	1.045e-56	202.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota,246N7@183980|Archaeoglobi	183980|Archaeoglobi	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRR25158203_k127_62709_3	877455.Metbo_1144	1.102e-52	194.0	COG0784@1|root,arCOG06712@1|root,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea,2XWYJ@28890|Euryarchaeota	28890|Euryarchaeota	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4,PAS_9,PadR,Response_reg
SRR25158203_k127_62709_0	1047013.AQSP01000140_gene2511	6.881e-82	295.0	COG2202@1|root,COG2203@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3920@2|Bacteria,2NPS5@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase	pdtaS	-	2.7.13.3	ko:K00936,ko:K02030	-	M00236,M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	HATPase_c,HATPase_c_2,H_kinase_N,HisKA_2,PAS_3,PAS_9
SRR25158203_k127_62709_4	1123009.AUID01000008_gene785	8.867e-15	78.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2691N@186813|unclassified Clostridiales	186801|Clostridia	KT	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
SRR25158203_k127_62709_1	647113.Metok_1036	8.148e-58	214.0	COG0642@1|root,arCOG02322@1|root,arCOG02322@2157|Archaea,arCOG07619@2157|Archaea,2Y7TB@28890|Euryarchaeota,23RVT@183939|Methanococci	183939|Methanococci	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
SRR25158203_k127_635377_3	1094980.Mpsy_2935	3.042e-44	162.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,2N9D1@224756|Methanomicrobia	224756|Methanomicrobia	E	Carbamoyl-phosphate synthase, small chain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
SRR25158203_k127_635377_4	693661.Arcve_1976	3.436e-44	164.0	COG1708@1|root,arCOG02107@2157|Archaea	2157|Archaea	S	DNA polymerase beta domain protein region	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR25158203_k127_635377_5	1133850.SHJG_3646	1.277e-22	100.0	2E3Z4@1|root,32YW2@2|Bacteria,2IQZ7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_635377_2	1094980.Mpsy_1047	6.019e-84	284.0	COG1842@1|root,arCOG04782@2157|Archaea,2XU11@28890|Euryarchaeota,2N9P1@224756|Methanomicrobia	224756|Methanomicrobia	K	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
SRR25158203_k127_635377_0	1094980.Mpsy_3165	5.396e-196	629.0	COG0433@1|root,arCOG03732@1|root,arCOG00280@2157|Archaea,arCOG03732@2157|Archaea,2Y7MA@28890|Euryarchaeota,2NA8T@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
SRR25158203_k127_635377_1	387631.Asulf_01641	8.022e-164	525.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,245QS@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
SRR25158203_k127_63937_5	192952.MM_2271	2.4e-122	397.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,2N96G@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SRR25158203_k127_63937_3	269797.Mbar_A3691	1.313e-147	477.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,2N927@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
SRR25158203_k127_63937_17	387631.Asulf_00700	4.912e-24	104.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,246FC@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
SRR25158203_k127_63937_13	304371.MCP_1221	7.419e-53	191.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2N9SC@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription termination protein NusA	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
SRR25158203_k127_63937_12	1094980.Mpsy_1012	1.361e-66	229.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,2N9J8@224756|Methanomicrobia	224756|Methanomicrobia	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
SRR25158203_k127_63937_11	192952.MM_2266	2.122e-70	242.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,2N9K7@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
SRR25158203_k127_63937_16	693661.Arcve_1699	6.929e-28	116.0	COG1324@1|root,arCOG04231@2157|Archaea,2XYPN@28890|Euryarchaeota,246D8@183980|Archaeoglobi	183980|Archaeoglobi	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
SRR25158203_k127_63937_2	1094980.Mpsy_0407	4.433e-171	553.0	COG0517@1|root,COG0750@1|root,arCOG00607@2157|Archaea,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,2N9D0@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
SRR25158203_k127_63937_15	269797.Mbar_A2546	5.147e-44	171.0	COG0805@1|root,arCOG01919@2157|Archaea,2Y7NT@28890|Euryarchaeota,2NB1J@224756|Methanomicrobia	224756|Methanomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	-	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
SRR25158203_k127_63937_10	1041930.Mtc_1071	7.231e-87	295.0	COG1712@1|root,arCOG00254@2157|Archaea,2XUNA@28890|Euryarchaeota,2NBJI@224756|Methanomicrobia	224756|Methanomicrobia	F	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
SRR25158203_k127_63937_8	192952.MM_2070	1.29e-97	325.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,2N950@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1867	QRPTase_C,QRPTase_N
SRR25158203_k127_63937_20	1280692.AUJL01000013_gene3277	7.239e-07	61.0	COG1361@1|root,COG1361@2|Bacteria,1UQ5B@1239|Firmicutes,24AUI@186801|Clostridia,36G18@31979|Clostridiaceae	186801|Clostridia	M	conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
SRR25158203_k127_63937_4	1094980.Mpsy_1278	3.761e-137	445.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota,2NB7I@224756|Methanomicrobia	224756|Methanomicrobia	D	Involved in cell shape control	cetZ	-	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
SRR25158203_k127_63937_18	192952.MM_1824	7.424e-23	100.0	COG1145@1|root,arCOG02445@2157|Archaea	2157|Archaea	C	4 iron, 4 sulfur cluster binding	-	-	-	ko:K11260	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4
SRR25158203_k127_63937_14	1041930.Mtc_1566	2.365e-52	192.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,2N9VK@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
SRR25158203_k127_63937_9	192952.MM_0460	3.873e-93	313.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,2N9UU@224756|Methanomicrobia	224756|Methanomicrobia	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
SRR25158203_k127_63937_19	555088.DealDRAFT_0037	1.763e-11	71.0	COG1633@1|root,COG1633@2|Bacteria,1V4P6@1239|Firmicutes,24IYH@186801|Clostridia	186801|Clostridia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SRR25158203_k127_63937_7	351160.RCIX2672	1.747e-102	340.0	COG1475@1|root,arCOG00622@2157|Archaea,2XTYJ@28890|Euryarchaeota,2NAPB@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,ParBc
SRR25158203_k127_63937_6	1094980.Mpsy_1622	2.162e-116	381.0	COG2524@1|root,arCOG00610@2157|Archaea,2XVPF@28890|Euryarchaeota,2N96A@224756|Methanomicrobia	224756|Methanomicrobia	K	signal transduction protein with CBS domains	-	-	-	ko:K07744	-	-	-	-	ko00000	-	-	-	CBS,HrcA_DNA-bdg
SRR25158203_k127_63937_0	1094980.Mpsy_1396	1.28e-189	600.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,2N9E0@224756|Methanomicrobia	224756|Methanomicrobia	G	Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
SRR25158203_k127_63937_1	1094980.Mpsy_2214	1.549e-180	597.0	arCOG03256@1|root,arCOG03256@2157|Archaea,2Y1RB@28890|Euryarchaeota	28890|Euryarchaeota	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
SRR25158203_k127_641170_3	1094980.Mpsy_1494	2.064e-36	146.0	COG1234@1|root,COG1650@1|root,arCOG00501@2157|Archaea,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,2N9S6@224756|Methanomicrobia	224756|Methanomicrobia	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
SRR25158203_k127_641170_0	1094980.Mpsy_1495	5.418e-162	516.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,2N926@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin,tRNA_deacylase
SRR25158203_k127_641170_1	1041930.Mtc_1131	1.786e-51	190.0	COG0602@1|root,arCOG02173@2157|Archaea,2XUSP@28890|Euryarchaeota,2N9MX@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
SRR25158203_k127_641170_4	192952.MM_1977	6.554e-17	87.0	arCOG04981@1|root,arCOG04981@2157|Archaea,2Y42Q@28890|Euryarchaeota,2NB1S@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_641170_2	1094980.Mpsy_2212	2.724e-45	175.0	arCOG04609@1|root,arCOG04609@2157|Archaea,2XVS1@28890|Euryarchaeota,2N9XU@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
SRR25158203_k127_65470_4	192952.MM_2233	4.338e-09	70.0	arCOG02538@1|root,arCOG02538@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,He_PIG,PKD,Peptidase_S8,S-layer
SRR25158203_k127_65470_5	406327.Mevan_0195	6.635e-09	61.0	COG4743@1|root,arCOG02884@2157|Archaea,2XU3K@28890|Euryarchaeota,23R6N@183939|Methanococci	183939|Methanococci	S	Protein of unknown function (DUF1616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1616
SRR25158203_k127_65470_6	67352.JODS01000001_gene168	1.734e-05	57.0	COG3469@1|root,COG3469@2|Bacteria,2GJTU@201174|Actinobacteria	201174|Actinobacteria	G	alpha-galactosidase	-	-	3.2.1.14,3.2.1.4	ko:K01179,ko:K01183	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R01206,R02334,R06200,R11307,R11308	RC00467	ko00000,ko00001,ko01000	-	GH18,GH5,GH9	-	CBM_2,CBM_4_9,Calx-beta,Cellulase,Glyco_hydro_18,PE,fn3
SRR25158203_k127_65470_3	1133850.SHJG_7504	1.315e-35	150.0	COG3409@1|root,COG3409@2|Bacteria,2GMGY@201174|Actinobacteria	201174|Actinobacteria	M	Fungal chitosanase of glycosyl hydrolase group 75	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_75
SRR25158203_k127_65470_2	192952.MM_3105	1.584e-49	183.0	COG1513@1|root,arCOG01488@2157|Archaea	2157|Archaea	P	CMP dCMP deaminase, zinc-binding	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
SRR25158203_k127_65470_1	269797.Mbar_A3600	1.042e-94	317.0	COG0616@1|root,arCOG01911@2157|Archaea,2XU7H@28890|Euryarchaeota,2N9SV@224756|Methanomicrobia	224756|Methanomicrobia	O	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
SRR25158203_k127_65470_0	192952.MM_2532	4.21e-97	331.0	COG3174@1|root,arCOG04203@2157|Archaea,2XT0W@28890|Euryarchaeota,2N9ST@224756|Methanomicrobia	224756|Methanomicrobia	P	MgtC family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
SRR25158203_k127_677675_4	1094980.Mpsy_2166	3.186e-51	184.0	arCOG03354@1|root,arCOG03353@2157|Archaea,2Y3N8@28890|Euryarchaeota,2NAX4@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1699)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1699
SRR25158203_k127_677675_0	555079.Toce_1716	3.59e-154	500.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,42F0V@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM 2-hydroxyglutaryl-CoA dehydratase D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SRR25158203_k127_677675_3	247490.KSU1_C0461	6.448e-71	249.0	COG1775@1|root,COG1924@1|root,COG1775@2|Bacteria,COG1924@2|Bacteria,2J22H@203682|Planctomycetes	203682|Planctomycetes	EI	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,HGD-D
SRR25158203_k127_677675_2	323259.Mhun_0758	1.185e-73	254.0	COG1136@1|root,arCOG00922@2157|Archaea,2XWHK@28890|Euryarchaeota,2N9GX@224756|Methanomicrobia	224756|Methanomicrobia	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR25158203_k127_677675_1	269797.Mbar_A2654	6.778e-77	272.0	COG0577@1|root,arCOG02315@2157|Archaea,2XYJU@28890|Euryarchaeota,2N9SS@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SRR25158203_k127_677675_5	323259.Mhun_1425	1.899e-39	161.0	COG1361@1|root,arCOG02080@2157|Archaea,2Y0I6@28890|Euryarchaeota,2N9ZF@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
SRR25158203_k127_677675_6	1206733.BAGC01000044_gene848	1.4e-27	116.0	2EHMA@1|root,33BD2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABM
SRR25158203_k127_677675_7	269797.Mbar_A1050	5.956e-07	57.0	COG4742@1|root,arCOG03134@2157|Archaea,2Y7NA@28890|Euryarchaeota	28890|Euryarchaeota	K	Domain of unknown function (DUF1724)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1724
SRR25158203_k127_684210_2	298653.Franean1_6516	4.861e-14	81.0	COG2864@1|root,COG2864@2|Bacteria,2GNYK@201174|Actinobacteria,4EV8W@85013|Frankiales	201174|Actinobacteria	C	Prokaryotic cytochrome b561	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
SRR25158203_k127_684210_1	1536772.R70723_29835	1.396e-48	182.0	COG2041@1|root,COG2041@2|Bacteria,1UZMG@1239|Firmicutes,4HM5S@91061|Bacilli,26S5Q@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
SRR25158203_k127_684210_0	269797.Mbar_A1564	4.091e-151	488.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,2N99G@224756|Methanomicrobia	224756|Methanomicrobia	S	PHP C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
SRR25158203_k127_684210_3	224325.AF_0059	1.237e-12	74.0	arCOG06109@1|root,arCOG06109@2157|Archaea,2XYU6@28890|Euryarchaeota,246E2@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_693160_7	525897.Dbac_1942	2.265e-44	179.0	COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria,42MHA@68525|delta/epsilon subdivisions,2WMF3@28221|Deltaproteobacteria,2MFXQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
SRR25158203_k127_693160_5	247490.KSU1_D0525	8.017e-49	176.0	COG0662@1|root,COG0662@2|Bacteria,2J4Q9@203682|Planctomycetes	203682|Planctomycetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
SRR25158203_k127_693160_11	1210908.HSB1_35090	6.816e-31	136.0	COG2244@1|root,arCOG02209@2157|Archaea,2XZJ5@28890|Euryarchaeota	28890|Euryarchaeota	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3
SRR25158203_k127_693160_9	192952.MM_0592	6.955e-39	152.0	COG1300@1|root,arCOG01994@2157|Archaea,2XTS9@28890|Euryarchaeota,2N9U5@224756|Methanomicrobia	224756|Methanomicrobia	S	Stage II sporulation protein M	-	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	SpoIIM
SRR25158203_k127_693160_2	269797.Mbar_A0290	1.112e-77	269.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,2N9NX@224756|Methanomicrobia	224756|Methanomicrobia	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
SRR25158203_k127_693160_0	192952.MM_0590	1.744e-147	474.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,2N90F@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
SRR25158203_k127_693160_8	269797.Mbar_A0292	7.562e-43	161.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,2N9VD@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
SRR25158203_k127_693160_13	879212.DespoDRAFT_03405	2.07e-18	90.0	COG4232@1|root,COG4232@2|Bacteria,1R1X1@1224|Proteobacteria,42SD6@68525|delta/epsilon subdivisions,2WP2I@28221|Deltaproteobacteria,2MKNH@213118|Desulfobacterales	28221|Deltaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2
SRR25158203_k127_693160_14	1345697.M493_07420	5.335e-16	91.0	298S5@1|root,2ZVWF@2|Bacteria,1V8I3@1239|Firmicutes,4HHTT@91061|Bacilli,1WE67@129337|Geobacillus	91061|Bacilli	S	Protein of unknown function with PCYCGC motif	-	-	-	-	-	-	-	-	-	-	-	-	PCYCGC
SRR25158203_k127_693160_10	1227454.C446_16992	1.881e-38	153.0	COG0785@1|root,arCOG02398@2157|Archaea,2XVQF@28890|Euryarchaeota,23VEA@183963|Halobacteria	183963|Halobacteria	O	COG0785 Cytochrome c biogenesis protein	ccdA	-	-	-	-	-	-	-	-	-	-	-	DsbD
SRR25158203_k127_693160_4	646529.Desaci_3886	7.81e-52	201.0	COG0348@1|root,COG0348@2|Bacteria,1U9JQ@1239|Firmicutes,24ADI@186801|Clostridia,264FV@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
SRR25158203_k127_693160_12	931277.C448_05763	2.179e-22	102.0	COG0526@1|root,arCOG01976@2157|Archaea,2XXBW@28890|Euryarchaeota,23W0E@183963|Halobacteria	183963|Halobacteria	O	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2,Thioredoxin_7
SRR25158203_k127_693160_1	797209.ZOD2009_09625	1.126e-96	344.0	COG1138@1|root,arCOG00270@2157|Archaea,2XUDS@28890|Euryarchaeota,23SWU@183963|Halobacteria	183963|Halobacteria	O	COG1138 Cytochrome c biogenesis factor	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
SRR25158203_k127_693160_15	1333523.L593_14325	8.146e-15	81.0	COG1522@1|root,arCOG01585@2157|Archaea,2XW1H@28890|Euryarchaeota,23VJ7@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	Arc_trans_TRASH,HTH_24,HTH_AsnC-type
SRR25158203_k127_693160_6	797304.Natgr_3131	1.149e-47	180.0	COG0785@1|root,arCOG02398@2157|Archaea,2XVQF@28890|Euryarchaeota,23VEA@183963|Halobacteria	183963|Halobacteria	O	COG0785 Cytochrome c biogenesis protein	ccdA	-	-	-	-	-	-	-	-	-	-	-	DsbD
SRR25158203_k127_693160_3	589924.Ferp_0391	3.656e-53	192.0	arCOG00937@1|root,arCOG00937@2157|Archaea,2Y2E6@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
SRR25158203_k127_69374_1	565033.GACE_1826	1.487e-42	166.0	arCOG07617@1|root,arCOG07617@2157|Archaea,2Y2J4@28890|Euryarchaeota,246WI@183980|Archaeoglobi	183980|Archaeoglobi	C	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Multi-haem_cyto
SRR25158203_k127_69374_2	706587.Desti_1528	1.333e-23	105.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,42VDR@68525|delta/epsilon subdivisions,2WRKS@28221|Deltaproteobacteria,2MSC8@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
SRR25158203_k127_69374_3	572546.Arcpr_1099	3.702e-17	84.0	COG1826@1|root,arCOG02694@2157|Archaea,2XZZ6@28890|Euryarchaeota,246CG@183980|Archaeoglobi	183980|Archaeoglobi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
SRR25158203_k127_69374_4	224325.AF_0177	2.132e-08	58.0	COG2191@1|root,arCOG00762@2157|Archaea,2XYR8@28890|Euryarchaeota	28890|Euryarchaeota	C	formylmethanofuran dehydrogenase, subunit E	fwdE	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
SRR25158203_k127_69374_0	706587.Desti_5093	4.33e-220	695.0	COG2202@1|root,COG3290@1|root,COG3829@1|root,COG4251@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CQ0@68525|delta/epsilon subdivisions,2X7X9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
SRR25158203_k127_710884_0	304371.MCP_2704	1.075e-103	344.0	COG0463@1|root,arCOG00894@2157|Archaea,2XTEG@28890|Euryarchaeota,2N988@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
SRR25158203_k127_710884_3	1041930.Mtc_0006	9.651e-56	202.0	COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,2N9SI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
SRR25158203_k127_710884_2	351160.RCIX1206	3.025e-62	222.0	COG2231@1|root,arCOG00461@2157|Archaea,2Y86S@28890|Euryarchaeota,2N9TD@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM HhH-GPD family protein	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
SRR25158203_k127_710884_1	368408.Tpen_0658	4.042e-78	267.0	COG2100@1|root,arCOG00951@2157|Archaea,2XPKN@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06935	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
SRR25158203_k127_717445_3	304371.MCP_0612	5.657e-59	210.0	COG1522@1|root,arCOG01580@2157|Archaea,2XXQR@28890|Euryarchaeota	28890|Euryarchaeota	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SRR25158203_k127_717445_6	1121459.AQXE01000001_gene2946	2.429e-08	57.0	COG1149@1|root,COG1149@2|Bacteria,1QYGR@1224|Proteobacteria,43CD0@68525|delta/epsilon subdivisions,2X7NV@28221|Deltaproteobacteria,2MHHA@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SRR25158203_k127_717445_2	1434325.AZQN01000007_gene3231	9.344e-62	217.0	arCOG14808@1|root,308PC@2|Bacteria,4NR4D@976|Bacteroidetes,47PEP@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
SRR25158203_k127_717445_1	929703.KE386491_gene175	1.396e-70	247.0	COG3025@1|root,COG3025@2|Bacteria,4NM6K@976|Bacteroidetes,47PAH@768503|Cytophagia	976|Bacteroidetes	S	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
SRR25158203_k127_717445_0	192952.MM_1393	1.476e-103	344.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,2N9FQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
SRR25158203_k127_717445_7	1009370.ALO_17825	7.583e-05	54.0	COG3316@1|root,COG3316@2|Bacteria,1TTKR@1239|Firmicutes	1239|Firmicutes	L	Transposase	tnp1216	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240,Zn_Tnp_IS1
SRR25158203_k127_717445_9	1449347.JQLN01000005_gene4556	0.0009015	46.0	COG2044@1|root,COG2044@2|Bacteria,2I1Z4@201174|Actinobacteria,2M5SD@2063|Kitasatospora	201174|Actinobacteria	S	PFAM DsrE DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_717445_5	758.BBIX01000008_gene863	7.253e-09	61.0	COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,1S3RB@1236|Gammaproteobacteria,1Y8ZA@135625|Pasteurellales	135625|Pasteurellales	P	DsrE/DsrF-like family	VY92_07695	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
SRR25158203_k127_717445_8	877455.Metbo_0143	0.0007031	47.0	COG2923@1|root,arCOG02069@2157|Archaea	2157|Archaea	P	protein involved in the oxidation of intracellular sulfur	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
SRR25158203_k127_717445_4	1123371.ATXH01000004_gene1750	9.39e-14	73.0	COG0425@1|root,COG0425@2|Bacteria,2GIKM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
SRR25158203_k127_725815_8	304371.MCP_0335	2.268e-31	123.0	COG0107@1|root,arCOG00617@2157|Archaea,2XU22@28890|Euryarchaeota,2N987@224756|Methanomicrobia	224756|Methanomicrobia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1514	His_biosynth
SRR25158203_k127_725815_3	269797.Mbar_A2060	3.198e-71	244.0	COG0269@1|root,arCOG00104@2157|Archaea,2Y3EV@28890|Euryarchaeota,2NAQI@224756|Methanomicrobia	224756|Methanomicrobia	C	Formaldehyde-activating enzyme (Fae)	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
SRR25158203_k127_725815_4	697282.Mettu_0615	4.908e-68	237.0	COG5483@1|root,COG5483@2|Bacteria,1PGPH@1224|Proteobacteria,1T9D9@1236|Gammaproteobacteria,1XGWM@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
SRR25158203_k127_725815_1	479434.Sthe_0632	1.401e-107	356.0	COG0122@1|root,COG0122@2|Bacteria,2G8TI@200795|Chloroflexi,27YWG@189775|Thermomicrobia	189775|Thermomicrobia	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
SRR25158203_k127_725815_9	269797.Mbar_A2923	1.784e-28	119.0	COG1153@1|root,arCOG02674@2157|Archaea,2Y4B7@28890|Euryarchaeota,2NB20@224756|Methanomicrobia	224756|Methanomicrobia	C	Molydopterin dinucleotide binding domain	-	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2923	Molydop_binding
SRR25158203_k127_725815_0	1094980.Mpsy_2957	1.678e-143	465.0	COG1029@1|root,arCOG01498@2157|Archaea,2XTYT@28890|Euryarchaeota,2NA77@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	-
SRR25158203_k127_725815_6	1094980.Mpsy_2956	1.101e-55	198.0	COG1145@1|root,arCOG00292@2157|Archaea,2XXJH@28890|Euryarchaeota,2NAU1@224756|Methanomicrobia	224756|Methanomicrobia	C	Putative Fe-S cluster	-	-	-	ko:K11260	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	FeS,Fer4
SRR25158203_k127_725815_2	1173024.KI912148_gene4265	3.654e-104	347.0	COG1752@1|root,COG1752@2|Bacteria,1G2F8@1117|Cyanobacteria,1JKGP@1189|Stigonemataceae	1117|Cyanobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
SRR25158203_k127_725815_11	374847.Kcr_0385	8.113e-14	83.0	COG1470@1|root,arCOG03511@1|root,arCOG07813@1|root,arCOG02087@2157|Archaea,arCOG03511@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.4.99.18,3.5.1.56	ko:K03418,ko:K07151	ko00510,ko00513,ko00630,ko01100,ko04141,map00510,map00513,map00630,map01100,map04141	M00072	R02509,R04216,R05976	RC00005,RC00111,RC00482,RC00731	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	CarboxypepD_reg,DUF2341,Laminin_G_3,PKD,Pilin_N,STT3
SRR25158203_k127_725815_5	304371.MCP_0700	1.353e-66	233.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,2N9IW@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
SRR25158203_k127_725815_10	224325.AF_1404	2.128e-25	110.0	COG1522@1|root,arCOG01117@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SRR25158203_k127_731024_0	871963.Desdi_1115	4.512e-147	482.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,24BV3@186801|Clostridia,26427@186807|Peptococcaceae	186801|Clostridia	O	PFAM Cytochrome C assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
SRR25158203_k127_731024_4	693661.Arcve_1988	4.72e-16	83.0	arCOG10396@1|root,arCOG10396@2157|Archaea,2Y14P@28890|Euryarchaeota,246H4@183980|Archaeoglobi	183980|Archaeoglobi	S	CcmE	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
SRR25158203_k127_731024_3	192952.MM_2235	6.073e-36	151.0	arCOG03691@1|root,arCOG03691@2157|Archaea	2157|Archaea	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_731024_6	269797.Mbar_A2219	4.566e-09	59.0	COG3350@1|root,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
SRR25158203_k127_731024_1	748727.CLJU_c40330	9.284e-135	449.0	COG0348@1|root,COG0348@2|Bacteria,1U9JQ@1239|Firmicutes,24ADI@186801|Clostridia,36F22@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
SRR25158203_k127_731024_7	673860.AciM339_0411	1.043e-07	56.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y76C@28890|Euryarchaeota,3F3GR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_731024_5	634177.GLX_29650	9.49e-16	87.0	COG5446@1|root,COG5446@2|Bacteria,1QS5Z@1224|Proteobacteria,2U2QH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Probable cobalt transporter subunit (CbtA)	-	-	-	-	-	-	-	-	-	-	-	-	CbtA
SRR25158203_k127_731024_2	269797.Mbar_A0803	2.628e-47	177.0	COG0640@1|root,arCOG01679@2157|Archaea,2Y46C@28890|Euryarchaeota,2NAYD@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_754546_5	251229.Chro_2690	2.889e-20	93.0	COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,3VIKA@52604|Pleurocapsales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CHASE,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_754546_1	1094980.Mpsy_0872	8.175e-63	243.0	COG0642@1|root,arCOG07619@2157|Archaea,2Y7TB@28890|Euryarchaeota	28890|Euryarchaeota	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_9,sCache_3_3
SRR25158203_k127_754546_0	1121448.DGI_3236	1.026e-69	248.0	COG2172@1|root,COG2172@2|Bacteria,1RD6C@1224|Proteobacteria,42Y96@68525|delta/epsilon subdivisions,2WU6U@28221|Deltaproteobacteria,2MCK7@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM Sporulation stage II, protein E C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,SpoIIE
SRR25158203_k127_754546_3	1122611.KB904018_gene7013	1.369e-36	142.0	COG2172@1|root,COG2172@2|Bacteria,2IKM9@201174|Actinobacteria,4EJFF@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	rsbT	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2,Sigma70_r2
SRR25158203_k127_754546_4	1121448.DGI_3238	2.039e-35	139.0	COG1366@1|root,COG1366@2|Bacteria,1RJM8@1224|Proteobacteria,430EC@68525|delta/epsilon subdivisions,2WVVK@28221|Deltaproteobacteria,2MDCK@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K17762	-	-	-	-	ko00000,ko03021	-	-	-	STAS
SRR25158203_k127_754546_2	1121448.DGI_3239	1.655e-44	169.0	COG1366@1|root,COG1366@2|Bacteria,1MVPW@1224|Proteobacteria,42Z6W@68525|delta/epsilon subdivisions,2WU82@28221|Deltaproteobacteria,2MC6W@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	RsbRD_N,STAS
SRR25158203_k127_757563_3	1094980.Mpsy_0710	9.683e-167	533.0	COG0677@1|root,arCOG00252@2157|Archaea,2Y2A7@28890|Euryarchaeota,2NA83@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SRR25158203_k127_757563_9	192952.MM_2042	1.223e-46	171.0	COG3355@1|root,arCOG02242@2157|Archaea,2XX1H@28890|Euryarchaeota,2NB0S@224756|Methanomicrobia	224756|Methanomicrobia	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
SRR25158203_k127_757563_11	192952.MM_0607	1.19e-09	60.0	arCOG04476@1|root,arCOG04476@2157|Archaea	2157|Archaea	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SRR25158203_k127_757563_8	593750.Metfor_2529	4.275e-56	199.0	arCOG11331@1|root,arCOG11331@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
SRR25158203_k127_757563_5	269797.Mbar_A3715	2.69e-77	271.0	COG4069@1|root,arCOG03231@2157|Archaea,2XV7V@28890|Euryarchaeota,2N9V3@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2117
SRR25158203_k127_757563_2	1094980.Mpsy_2891	6.744e-211	661.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,2N93F@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0200	CdhD
SRR25158203_k127_757563_1	1094980.Mpsy_2890	6.738e-226	707.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
SRR25158203_k127_757563_4	565033.GACE_0218	6.131e-84	291.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,245QE@183980|Archaeoglobi	183980|Archaeoglobi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SRR25158203_k127_757563_10	192952.MM_1699	1.862e-36	142.0	arCOG02435@1|root,arCOG02435@2157|Archaea,2XX22@28890|Euryarchaeota,2NAYP@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009123,GO:0009125,GO:0009159,GO:0009162,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070694,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
SRR25158203_k127_757563_6	66875.JODY01000018_gene379	7.347e-74	256.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria	201174|Actinobacteria	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
SRR25158203_k127_757563_0	335543.Sfum_2104	2.631e-240	754.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2MRE3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	succinate dehydrogenase or fumarate reductase, flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SRR25158203_k127_757563_7	266117.Rxyl_1079	1.383e-73	258.0	COG1606@1|root,COG1606@2|Bacteria,2GPA1@201174|Actinobacteria	201174|Actinobacteria	S	PFAM ExsB family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,HAD,HAD_2,Hydrolase_like,NAD_synthase
SRR25158203_k127_777870_2	192952.MM_3081	1.044e-91	310.0	COG0478@1|root,arCOG01181@2157|Archaea,2XUJ4@28890|Euryarchaeota,2N9I8@224756|Methanomicrobia	224756|Methanomicrobia	T	Rio2, N-terminal	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
SRR25158203_k127_777870_3	439481.Aboo_0797	2.733e-25	112.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y72Y@28890|Euryarchaeota,3F3AT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
SRR25158203_k127_777870_1	192952.MM_0853	9.001e-101	334.0	COG1235@1|root,arCOG00499@2157|Archaea,2XTWY@28890|Euryarchaeota,2N9GT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM beta-lactamase domain protein	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
SRR25158203_k127_777870_0	1041930.Mtc_1759	1.051e-108	356.0	COG0464@1|root,arCOG04368@2157|Archaea,2XT63@28890|Euryarchaeota,2N9B2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
SRR25158203_k127_794594_1	1094980.Mpsy_1294	4.027e-107	351.0	COG1891@1|root,arCOG04482@2157|Archaea,2XUBQ@28890|Euryarchaeota,2N952@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P)	mfnB	-	4.2.3.153	ko:K09733	ko00680,map00680	-	R10935	RC03315	ko00000,ko00001,ko01000	-	-	-	4HFCP_synth
SRR25158203_k127_794594_0	1121430.JMLG01000005_gene721	4.306e-122	401.0	COG1060@1|root,COG1060@2|Bacteria,1TQNG@1239|Firmicutes,24AHE@186801|Clostridia,260QC@186807|Peptococcaceae	186801|Clostridia	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
SRR25158203_k127_794594_2	1094980.Mpsy_1602	4.433e-45	176.0	COG4885@1|root,arCOG04478@2157|Archaea,2XTQQ@28890|Euryarchaeota,2NANM@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_794594_4	269797.Mbar_A0823	2.409e-10	63.0	arCOG03925@1|root,arCOG03925@2157|Archaea,2Y6WQ@28890|Euryarchaeota,2NB9M@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_794594_3	269797.Mbar_A3436	2.749e-36	143.0	COG1821@1|root,arCOG01592@2157|Archaea,2XXPE@28890|Euryarchaeota,2N9JU@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	6.3.4.24	ko:K06914	ko00680,map00680	-	R10902	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_3
SRR25158203_k127_794696_5	1459636.NTE_03538	2.429e-30	126.0	COG0506@1|root,arCOG06322@2157|Archaea,41SY1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
SRR25158203_k127_794696_4	1094980.Mpsy_2190	5.354e-42	157.0	arCOG06554@1|root,arCOG06554@2157|Archaea,2Y169@28890|Euryarchaeota	28890|Euryarchaeota	S	Family of unknown function (DUF5402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5402
SRR25158203_k127_794696_3	478741.JAFS01000001_gene2020	6.889e-58	207.0	COG0655@1|root,COG0655@2|Bacteria,46ZCX@74201|Verrucomicrobia,37H9G@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Flavodoxin-like fold	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
SRR25158203_k127_794696_6	1041930.Mtc_1611	1.198e-19	92.0	COG0640@1|root,arCOG00394@2157|Archaea,2XYXY@28890|Euryarchaeota,2NBEM@224756|Methanomicrobia	224756|Methanomicrobia	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SRR25158203_k127_794696_0	1094980.Mpsy_1670	5.759e-182	578.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,2N9BK@224756|Methanomicrobia	224756|Methanomicrobia	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
SRR25158203_k127_794696_1	237368.SCABRO_00405	4.416e-172	561.0	COG0369@1|root,COG1151@2|Bacteria	2|Bacteria	C	hydroxylamine reductase activity	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
SRR25158203_k127_794696_2	1094980.Mpsy_0399	6.013e-123	404.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,2N9A6@224756|Methanomicrobia	224756|Methanomicrobia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
SRR25158203_k127_799503_9	204669.Acid345_2713	1.016e-08	66.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
SRR25158203_k127_799503_4	991.IW20_09855	3.465e-22	102.0	COG2146@1|root,COG2146@2|Bacteria,4NMQ1@976|Bacteroidetes,1I3V0@117743|Flavobacteriia,2NSHS@237|Flavobacterium	976|Bacteroidetes	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
SRR25158203_k127_799503_2	1120973.AQXL01000134_gene1561	5.811e-71	246.0	COG1290@1|root,COG1290@2|Bacteria,1TP6M@1239|Firmicutes,4H9XV@91061|Bacilli,27843@186823|Alicyclobacillaceae	91061|Bacilli	C	Cytochrome b(N-terminal)/b6/petB	qcrB	-	-	ko:K03887	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_B
SRR25158203_k127_799503_7	696281.Desru_1526	4.225e-12	72.0	COG1290@1|root,COG1290@2|Bacteria,1VJ5K@1239|Firmicutes,24U1A@186801|Clostridia,2650I@186807|Peptococcaceae	186801|Clostridia	C	Cytochrome b subunit of the bc complex	-	-	-	ko:K02637	ko00195,ko01100,map00195,map01100	M00162	-	-	ko00000,ko00001,ko00002,ko00194	-	-	-	Cytochrom_B_C
SRR25158203_k127_799503_5	469383.Cwoe_2901	7.745e-14	74.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF836
SRR25158203_k127_799503_3	1267534.KB906758_gene2184	5.995e-70	246.0	COG0500@1|root,COG2226@2|Bacteria,3Y8AQ@57723|Acidobacteria	57723|Acidobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
SRR25158203_k127_799503_1	246969.TAM4_546	9.692e-83	292.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,242SX@183968|Thermococci	183968|Thermococci	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SRR25158203_k127_799503_6	589924.Ferp_0703	2.303e-13	75.0	COG1310@1|root,arCOG01138@2157|Archaea,2Y1J4@28890|Euryarchaeota,247CF@183980|Archaeoglobi	183980|Archaeoglobi	S	JAB/MPN domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
SRR25158203_k127_799503_10	224325.AF_1478	7.758e-06	52.0	COG1753@1|root,arCOG02681@2157|Archaea	2157|Archaea	S	Possibly the antitoxin component of a	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
SRR25158203_k127_799503_0	1094980.Mpsy_1309	1.239e-101	336.0	COG2516@1|root,arCOG00662@2157|Archaea,2XV52@28890|Euryarchaeota,2N9EK@224756|Methanomicrobia	224756|Methanomicrobia	S	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SRR25158203_k127_800146_10	469383.Cwoe_4252	5.371e-08	64.0	arCOG08211@1|root,2ZBM3@2|Bacteria,2IDNP@201174|Actinobacteria,4CTVG@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_800146_4	269797.Mbar_A0552	7.01e-83	283.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,2N9HI@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain protein	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SRR25158203_k127_800146_0	1094980.Mpsy_1638	1.275e-182	575.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,2N99Q@224756|Methanomicrobia	224756|Methanomicrobia	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
SRR25158203_k127_800146_1	521011.Mpal_2509	2.261e-180	571.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
SRR25158203_k127_800146_5	269797.Mbar_A0549	6.307e-52	186.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,2N9PT@224756|Methanomicrobia	224756|Methanomicrobia	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SRR25158203_k127_800146_2	192952.MM_1523	3.874e-118	391.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,2NACS@224756|Methanomicrobia	224756|Methanomicrobia	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
SRR25158203_k127_800146_3	1254432.SCE1572_23125	2.064e-99	331.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2YUA5@29|Myxococcales	28221|Deltaproteobacteria	HP	domain protein	moeB1	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
SRR25158203_k127_800146_7	589924.Ferp_2210	2.003e-22	99.0	COG0425@1|root,arCOG02062@2157|Archaea,2Y78N@28890|Euryarchaeota,246GB@183980|Archaeoglobi	183980|Archaeoglobi	O	Sulfurtransferase TusA	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
SRR25158203_k127_800146_8	1158345.JNLL01000001_gene177	7.094e-11	67.0	COG1553@1|root,COG1553@2|Bacteria,2G5DU@200783|Aquificae	200783|Aquificae	P	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
SRR25158203_k127_800146_9	123214.PERMA_0126	1.039e-09	63.0	COG2923@1|root,COG2923@2|Bacteria,2G5D8@200783|Aquificae	200783|Aquificae	P	DsrE/DsrF-like family	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
SRR25158203_k127_800146_6	1287276.X752_17805	8.587e-31	123.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TTXA@28211|Alphaproteobacteria,43HGM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	HI0933-like protein	yhiN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
SRR25158203_k127_80796_0	269797.Mbar_A3698	3.208e-185	599.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
SRR25158203_k127_80796_2	1094980.Mpsy_2608	2.082e-50	181.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,2N9U3@224756|Methanomicrobia	224756|Methanomicrobia	J	hydrolase	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
SRR25158203_k127_80796_4	589924.Ferp_1820	6.321e-11	67.0	arCOG10234@1|root,arCOG10234@2157|Archaea,2Y4PW@28890|Euryarchaeota,24791@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_80796_3	192952.MM_1382	1.506e-48	181.0	COG2043@1|root,arCOG02289@2157|Archaea	2157|Archaea	IQ	PFAM Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
SRR25158203_k127_80796_5	1185876.BN8_04678	7.444e-06	59.0	COG0457@1|root,COG0457@2|Bacteria	1185876.BN8_04678|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_80796_6	1209072.ALBT01000038_gene2367	0.0002046	55.0	COG0457@1|root,COG0457@2|Bacteria,1NB8N@1224|Proteobacteria,1SEZN@1236|Gammaproteobacteria,1FFS9@10|Cellvibrio	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_12,TPR_16,TPR_6,TPR_8
SRR25158203_k127_80796_1	1379698.RBG1_1C00001G1307	9.899e-78	289.0	COG0457@1|root,COG0457@2|Bacteria,2NPK1@2323|unclassified Bacteria	2|Bacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
SRR25158203_k127_812383_10	795797.C497_06529	8.634e-07	55.0	COG0640@1|root,arCOG03065@2157|Archaea,2Y07S@28890|Euryarchaeota,23XRE@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20
SRR25158203_k127_812383_7	653733.Selin_0567	7.866e-23	103.0	COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	vnfA	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding
SRR25158203_k127_812383_4	572546.Arcpr_1589	2.091e-53	201.0	COG1035@1|root,arCOG02650@2157|Archaea,2XVXF@28890|Euryarchaeota,2462X@183980|Archaeoglobi	28890|Euryarchaeota	C	PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit	-	-	1.1.98.4,1.12.98.1	ko:K00441,ko:K22174	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_21,FrhB_FdhB_C,FrhB_FdhB_N
SRR25158203_k127_812383_2	589924.Ferp_0126	2.811e-110	373.0	COG0348@1|root,arCOG02772@2157|Archaea,2Y7DD@28890|Euryarchaeota,246PC@183980|Archaeoglobi	183980|Archaeoglobi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
SRR25158203_k127_812383_11	1163409.UUA_00745	0.0002481	49.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,1RQSW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	COX2,Cupredoxin_1
SRR25158203_k127_812383_5	1395571.TMS3_0107060	6.44e-47	185.0	COG4885@1|root,COG4885@2|Bacteria,1R65B@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_CBB3
SRR25158203_k127_812383_3	1121918.ARWE01000001_gene2619	1.6e-108	378.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	GSu_C4xC__C2xCH,Paired_CXXCH_1
SRR25158203_k127_812383_0	679926.Mpet_1125	8.95e-135	434.0	COG2899@1|root,arCOG05299@2157|Archaea,2Y4HF@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF475)	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
SRR25158203_k127_812383_6	221288.JH992901_gene4697	2.556e-42	160.0	COG3793@1|root,COG3793@2|Bacteria,1G6ZI@1117|Cyanobacteria,1JIP1@1189|Stigonemataceae	1117|Cyanobacteria	P	PFAM Mo-dependent nitrogenase	-	-	-	-	-	-	-	-	-	-	-	-	TerB
SRR25158203_k127_812383_9	1227457.C451_13511	2.485e-12	71.0	arCOG02498@1|root,arCOG02498@2157|Archaea,2Y82I@28890|Euryarchaeota,2413G@183963|Halobacteria	183963|Halobacteria	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
SRR25158203_k127_812383_1	269797.Mbar_A0761	1.076e-117	391.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,2N9FA@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
SRR25158203_k127_812383_8	913865.DOT_0076	9.034e-20	99.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia,26612@186807|Peptococcaceae	186801|Clostridia	H	Lipoate-protein ligase	lipM	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SRR25158203_k127_838238_1	555088.DealDRAFT_1378	1.086e-76	266.0	COG2221@1|root,COG2221@2|Bacteria,1TR7P@1239|Firmicutes,2493K@186801|Clostridia	186801|Clostridia	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
SRR25158203_k127_838238_0	1288826.MSNKSG1_06633	5.384e-110	359.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,1RNC5@1236|Gammaproteobacteria,4669P@72275|Alteromonadaceae	1236|Gammaproteobacteria	EH	Reduction of activated sulfate into sulfite	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_2328	PAPS_reduct
SRR25158203_k127_838238_3	926690.KE386573_gene818	1.208e-08	60.0	arCOG04629@1|root,arCOG04629@2157|Archaea,2XZI9@28890|Euryarchaeota,23WU3@183963|Halobacteria	183963|Halobacteria	K	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,UPF0175
SRR25158203_k127_838238_4	565033.GACE_1105	4.269e-05	48.0	COG2886@1|root,arCOG00722@2157|Archaea,2Y1NZ@28890|Euryarchaeota,2477E@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
SRR25158203_k127_838238_2	269797.Mbar_A2420	2.343e-44	167.0	COG1413@1|root,arCOG02973@2157|Archaea,2Y2I3@28890|Euryarchaeota,2NAKY@224756|Methanomicrobia	224756|Methanomicrobia	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
SRR25158203_k127_844243_13	593750.Metfor_2386	1.425e-06	55.0	arCOG01151@1|root,arCOG01151@2157|Archaea	2157|Archaea	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
SRR25158203_k127_844243_6	387631.Asulf_01706	6.77e-69	237.0	COG1814@1|root,arCOG01096@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
SRR25158203_k127_844243_8	1041930.Mtc_1015	3.927e-43	174.0	COG0457@1|root,arCOG03042@1|root,arCOG03032@2157|Archaea,arCOG03042@2157|Archaea,2Y7M7@28890|Euryarchaeota,2NBM0@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
SRR25158203_k127_844243_12	502025.Hoch_1899	6.694e-09	62.0	COG2524@1|root,COG2524@2|Bacteria,1QANB@1224|Proteobacteria,43E2I@68525|delta/epsilon subdivisions,2WZHW@28221|Deltaproteobacteria,2Z26K@29|Myxococcales	28221|Deltaproteobacteria	K	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_844243_1	1047013.AQSP01000045_gene110	5.402e-157	508.0	COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905,iNJ661.Rv2130c	DALR_2,tRNA-synt_1e,tRNA-synt_1g
SRR25158203_k127_844243_3	1094980.Mpsy_2705	2.154e-136	446.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,2N985@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
SRR25158203_k127_844243_7	1041930.Mtc_1946	3.36e-52	188.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,2N9R5@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
SRR25158203_k127_844243_4	304371.MCP_1739	1.905e-102	340.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,2N9E1@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
SRR25158203_k127_844243_9	269797.Mbar_A1584	8.351e-20	90.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,2NA1K@224756|Methanomicrobia	224756|Methanomicrobia	L	Histone-like transcription factor (CBF/NF-Y) and archaeal histone	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
SRR25158203_k127_844243_0	351160.RCIX2757	3.351e-218	683.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,2N94Z@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
SRR25158203_k127_844243_11	366602.Caul_0316	5.089e-09	63.0	COG0697@1|root,COG0697@2|Bacteria,1R25S@1224|Proteobacteria,2U51J@28211|Alphaproteobacteria,2KHPG@204458|Caulobacterales	204458|Caulobacterales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRR25158203_k127_844243_10	243164.DET0914	7.783e-15	83.0	2BVIG@1|root,32QWN@2|Bacteria,2GAP2@200795|Chloroflexi,34CXJ@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_844243_5	552811.Dehly_0432	2.398e-98	336.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
SRR25158203_k127_844243_2	368407.Memar_1826	1.569e-152	492.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota,2N9VR@224756|Methanomicrobia	224756|Methanomicrobia	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
SRR25158203_k127_856137_4	243231.GSU1538	0.0001496	44.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
SRR25158203_k127_856137_2	1094980.Mpsy_1208	5.095e-23	103.0	COG0426@1|root,arCOG00509@2157|Archaea,2XYDW@28890|Euryarchaeota,2N9PY@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
SRR25158203_k127_856137_1	351160.RRC124	4.778e-114	382.0	COG0508@1|root,arCOG01706@2157|Archaea,2XTSS@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SRR25158203_k127_856137_0	1121405.dsmv_1099	9.614e-131	424.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2MMZ0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
SRR25158203_k127_856137_3	441768.ACL_1312	1.448e-05	49.0	COG1071@1|root,COG1071@2|Bacteria,3WSVZ@544448|Tenericutes	544448|Tenericutes	C	pyruvate dehydrogenase e1 component, alpha subunit	pdhA	GO:0003674,GO:0005488,GO:0005515,GO:0140030,GO:0140032	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
SRR25158203_k127_87428_0	269797.Mbar_A1375	2e-169	542.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,2N94C@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
SRR25158203_k127_87428_2	747365.Thena_0865	1.377e-127	416.0	COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,24GKF@186801|Clostridia,42HT2@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
SRR25158203_k127_87428_1	698757.Pogu_0803	2.068e-128	428.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
SRR25158203_k127_87428_3	192952.MM_2189	5.516e-103	336.0	COG1592@1|root,arCOG01097@2157|Archaea,2XXBF@28890|Euryarchaeota,2NAY4@224756|Methanomicrobia	224756|Methanomicrobia	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SRR25158203_k127_87428_8	1293047.CBMA010000017_gene1029	9.936e-21	96.0	COG2402@1|root,arCOG04502@2157|Archaea,2XXE8@28890|Euryarchaeota,23VKJ@183963|Halobacteria	183963|Halobacteria	V	nucleic acid-binding protein, contains PIN domain	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
SRR25158203_k127_87428_9	1227497.C491_06928	1.889e-09	65.0	arCOG07990@1|root,arCOG07990@2157|Archaea,2XZ08@28890|Euryarchaeota,23X6V@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_87428_4	192952.MM_2309	3.988e-57	212.0	COG3366@1|root,arCOG00360@2157|Archaea,2XTBS@28890|Euryarchaeota,2NAST@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM nucleoside recognition domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_87428_7	1094980.Mpsy_1845	7.46e-21	94.0	arCOG03086@1|root,arCOG03086@2157|Archaea	2157|Archaea	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
SRR25158203_k127_87428_6	192952.MM_0202	1.017e-22	98.0	COG1598@1|root,arCOG02411@2157|Archaea,2Y4FJ@28890|Euryarchaeota,2NB82@224756|Methanomicrobia	224756|Methanomicrobia	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
SRR25158203_k127_87428_5	675817.VDA_003192	3.974e-24	106.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1Y2EE@135623|Vibrionales	135623|Vibrionales	L	Group II intron, maturase-specific domain	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
SRR25158203_k127_881099_8	483218.BACPEC_01559	1.106e-11	66.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia,269DS@186813|unclassified Clostridiales	186801|Clostridia	NT	CheC-like family	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
SRR25158203_k127_881099_4	1094980.Mpsy_2595	1.049e-80	278.0	COG1352@1|root,arCOG04402@2157|Archaea,2XU3Q@28890|Euryarchaeota,2N9NH@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM MCP methyltransferase CheR-type	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
SRR25158203_k127_881099_1	1321786.HMPREF1992_00529	9.014e-174	565.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,4H3AN@909932|Negativicutes	909932|Negativicutes	NT	Chemotaxis protein CheA	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
SRR25158203_k127_881099_3	1094980.Mpsy_2599	3.017e-108	361.0	COG2201@1|root,arCOG02382@2157|Archaea,2XUKR@28890|Euryarchaeota,2N9H6@224756|Methanomicrobia	224756|Methanomicrobia	N	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
SRR25158203_k127_881099_6	941639.BCO26_1145	4.656e-39	148.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4HGY2@91061|Bacilli,1ZG7Q@1386|Bacillus	91061|Bacilli	T	response regulator	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
SRR25158203_k127_881099_2	1094980.Mpsy_2351	3.258e-149	489.0	COG1955@1|root,arCOG01809@2157|Archaea,2XTAX@28890|Euryarchaeota,2N9WG@224756|Methanomicrobia	224756|Methanomicrobia	N	type II secretion system protein	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SRR25158203_k127_881099_0	1094980.Mpsy_2350	2.675e-212	672.0	COG4962@1|root,arCOG01817@2157|Archaea,2XTDM@28890|Euryarchaeota,2N9CE@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRR25158203_k127_881099_5	1094980.Mpsy_2349	2.526e-75	259.0	COG2874@1|root,arCOG04148@2157|Archaea,2XUMD@28890|Euryarchaeota,2N9IB@224756|Methanomicrobia	224756|Methanomicrobia	N	KaiC	-	-	-	ko:K07331	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ATPase
SRR25158203_k127_881099_7	1094980.Mpsy_2348	4.427e-32	130.0	COG3354@1|root,arCOG01822@2157|Archaea,2Y176@28890|Euryarchaeota	28890|Euryarchaeota	N	Archaebacterial flagellin	-	-	-	ko:K07330	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SRR25158203_k127_881099_9	1070774.J07HN4v3_03066	6.287e-09	63.0	COG3353@1|root,arCOG01824@2157|Archaea,2XYQP@28890|Euryarchaeota,23WWZ@183963|Halobacteria	183963|Halobacteria	N	archaeal flagellar protein F	flaF	-	-	ko:K07329	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SRR25158203_k127_881099_10	1094980.Mpsy_0480	2.909e-06	51.0	COG1681@1|root,arCOG01829@2157|Archaea,2XTEE@28890|Euryarchaeota	28890|Euryarchaeota	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB1	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
SRR25158203_k127_893262_5	673860.AciM339_0583	3.274e-40	158.0	COG0475@1|root,arCOG01953@2157|Archaea,2XV77@28890|Euryarchaeota	28890|Euryarchaeota	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
SRR25158203_k127_893262_4	316067.Geob_2509	7.705e-49	186.0	COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,42QIT@68525|delta/epsilon subdivisions,2WKAX@28221|Deltaproteobacteria,43SD9@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR25158203_k127_893262_0	456442.Mboo_1105	4.698e-110	361.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
SRR25158203_k127_893262_2	456442.Mboo_1105	2.566e-72	247.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
SRR25158203_k127_893262_1	269797.Mbar_A2318	3.136e-92	314.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,2N98I@224756|Methanomicrobia	224756|Methanomicrobia	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SRR25158203_k127_893262_3	269797.Mbar_A2319	2.529e-57	206.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,2N9EI@224756|Methanomicrobia	224756|Methanomicrobia	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
SRR25158203_k127_900245_1	247490.KSU1_C0085	7.221e-87	291.0	COG0225@1|root,COG0225@2|Bacteria,2IZ67@203682|Planctomycetes	203682|Planctomycetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
SRR25158203_k127_900245_3	436229.JOEH01000008_gene4208	1.771e-06	49.0	COG4430@1|root,COG4430@2|Bacteria,2I1Y7@201174|Actinobacteria,2NK6V@228398|Streptacidiphilus	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_900245_4	1321778.HMPREF1982_00481	3.401e-05	48.0	COG4430@1|root,COG4430@2|Bacteria,1VG0C@1239|Firmicutes	1239|Firmicutes	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_900245_2	269797.Mbar_A1096	5.059e-36	140.0	COG4048@1|root,arCOG04902@2157|Archaea,2Y8FE@28890|Euryarchaeota,2N9Y6@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2111)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2111
SRR25158203_k127_900245_0	1173024.KI912154_gene922	4.207e-146	485.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1JI3P@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_917419_6	290317.Cpha266_2626	2.199e-07	52.0	COG3335@1|root,COG3335@2|Bacteria,1FEIY@1090|Chlorobi	1090|Chlorobi	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
SRR25158203_k127_917419_1	192952.MM_2528	2.875e-128	421.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,2N97Q@224756|Methanomicrobia	224756|Methanomicrobia	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
SRR25158203_k127_917419_2	269797.Mbar_A1179	3.63e-125	409.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
SRR25158203_k127_917419_0	1094980.Mpsy_1387	4.253e-154	491.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,2N92B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAB	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
SRR25158203_k127_917419_4	304371.MCP_1660	6.631e-86	295.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
SRR25158203_k127_917419_5	243231.GSU1926	3.382e-23	107.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,42X7G@68525|delta/epsilon subdivisions,2WSX9@28221|Deltaproteobacteria,43VJC@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
SRR25158203_k127_917419_3	351160.LRC454	2.044e-99	342.0	arCOG04580@1|root,arCOG04580@2157|Archaea,2XUWY@28890|Euryarchaeota,2NA9J@224756|Methanomicrobia	224756|Methanomicrobia	Q	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
SRR25158203_k127_941051_12	1094980.Mpsy_0384	2.521e-06	58.0	arCOG03269@1|root,arCOG03269@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF11,PKD
SRR25158203_k127_941051_4	192952.MM_1369	1.364e-79	272.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
SRR25158203_k127_941051_2	1094980.Mpsy_0392	2.242e-107	353.0	COG3640@1|root,arCOG00587@2157|Archaea,2XW7J@28890|Euryarchaeota,2N9VV@224756|Methanomicrobia	224756|Methanomicrobia	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
SRR25158203_k127_941051_5	192952.MM_2533	3.633e-69	241.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXXF@28890|Euryarchaeota,2N9PM@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SRR25158203_k127_941051_9	351160.RCIX403	4.403e-47	176.0	COG0727@1|root,arCOG02579@2157|Archaea,2XTK2@28890|Euryarchaeota,2N9XG@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SRR25158203_k127_941051_6	1094980.Mpsy_2215	1.422e-62	219.0	COG4800@1|root,arCOG04375@2157|Archaea,2XXJS@28890|Euryarchaeota,2N9MB@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
SRR25158203_k127_941051_7	224325.AF_0640	5.385e-56	209.0	COG0715@1|root,arCOG01803@2157|Archaea,2Y7DP@28890|Euryarchaeota,246X9@183980|Archaeoglobi	183980|Archaeoglobi	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
SRR25158203_k127_941051_10	387631.Asulf_00358	1.179e-45	175.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,246K8@183980|Archaeoglobi	183980|Archaeoglobi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SRR25158203_k127_941051_3	351160.RCIX444	9.536e-93	312.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SRR25158203_k127_941051_13	1185653.A1A1_14414	0.000928	50.0	COG0589@1|root,COG0589@2|Bacteria,1V6RY@1239|Firmicutes,4HIZM@91061|Bacilli,26FGB@186818|Planococcaceae	91061|Bacilli	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SRR25158203_k127_941051_0	1220534.B655_1054	2.894e-250	801.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota	28890|Euryarchaeota	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
SRR25158203_k127_941051_8	593750.Metfor_2194	6.075e-50	206.0	arCOG02348@1|root,arCOG02352@1|root,arCOG04001@1|root,arCOG06940@1|root,arCOG02348@2157|Archaea,arCOG02352@2157|Archaea,arCOG04001@2157|Archaea,arCOG06940@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
SRR25158203_k127_941051_1	1173022.Cri9333_1031	1.066e-176	604.0	COG0784@1|root,COG3852@1|root,COG4566@1|root,COG0784@2|Bacteria,COG3852@2|Bacteria,COG4566@2|Bacteria,1GHJE@1117|Cyanobacteria,1HHX1@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
SRR25158203_k127_956080_10	296591.Bpro_4097	9.077e-27	122.0	COG2159@1|root,COG2159@2|Bacteria,1Q0C8@1224|Proteobacteria,2W550@28216|Betaproteobacteria,4AIVM@80864|Comamonadaceae	28216|Betaproteobacteria	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_956080_9	351160.RCIX2161	2.383e-33	133.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,2NB15@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
SRR25158203_k127_956080_1	192952.MM_0476	5.76e-148	475.0	COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota,2N9EF@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
SRR25158203_k127_956080_8	1094980.Mpsy_1166	1.301e-54	196.0	COG0517@1|root,arCOG00606@2157|Archaea,2XZ85@28890|Euryarchaeota,2N9UA@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR25158203_k127_956080_2	1094980.Mpsy_1165	1.759e-140	456.0	COG1364@1|root,arCOG04413@2157|Archaea,2XUG6@28890|Euryarchaeota,2N99N@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2003	ArgJ
SRR25158203_k127_956080_7	304371.MCP_2753	2.218e-63	226.0	COG1719@1|root,arCOG01688@2157|Archaea,2XY7Q@28890|Euryarchaeota,2N9Q7@224756|Methanomicrobia	224756|Methanomicrobia	K	V4R	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	HTH_5,V4R
SRR25158203_k127_956080_3	304371.MCP_0008	1.231e-128	420.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,2N9A4@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SRR25158203_k127_956080_11	1041930.Mtc_0441	2.557e-22	102.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
SRR25158203_k127_956080_12	1094980.Mpsy_0491	2.741e-13	71.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y6W8@28890|Euryarchaeota,2NA5B@224756|Methanomicrobia	224756|Methanomicrobia	J	Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
SRR25158203_k127_956080_5	1121468.AUBR01000024_gene3034	1.122e-70	249.0	2C3VA@1|root,32RCU@2|Bacteria,1VXKS@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR25158203_k127_956080_6	1094980.Mpsy_0486	2.041e-66	234.0	COG0134@1|root,arCOG01088@2157|Archaea,2XTWK@28890|Euryarchaeota,2N9V0@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3621	IGPS
SRR25158203_k127_956080_0	1094980.Mpsy_0487	4.782e-193	608.0	COG0133@1|root,arCOG01433@2157|Archaea,2XUHQ@28890|Euryarchaeota,2N9DF@224756|Methanomicrobia	224756|Methanomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRR25158203_k127_956080_4	1094980.Mpsy_0488	8.685e-103	340.0	COG0159@1|root,arCOG01086@2157|Archaea,2XTAW@28890|Euryarchaeota,2N9KY@224756|Methanomicrobia	224756|Methanomicrobia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
SRR25158203_k127_956080_13	1151292.QEW_1010	1.397e-11	69.0	COG0863@1|root,COG0863@2|Bacteria,1TPR7@1239|Firmicutes,24A3P@186801|Clostridia	186801|Clostridia	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
## 2519 queries scanned
## Total time (seconds): 2.5010321140289307
## Rate: 1007.18 q/s