## Sat Dec 13 14:52:36 2025
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/qs/new/SRR21617310_bin.21.fa -m mmseqs --itype genome -o SRR21617310_bin.21 --output_dir /data/result/bins/wyx/egg/SRR21617310_bin.21 --cpu 32
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
SRR21617310_k127_1008883_1	1089553.Tph_c26470	5.841e-108	373.0	COG1449@1|root,COG1449@2|Bacteria,1VS0V@1239|Firmicutes,24YAY@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1008883_2	1156937.MFUM_40011	3.045e-09	69.0	COG1449@1|root,COG1449@2|Bacteria,46Z1Y@74201|Verrucomicrobia,37H38@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
SRR21617310_k127_1008883_0	335543.Sfum_3452	4.281e-121	400.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,42PZB@68525|delta/epsilon subdivisions,2WK77@28221|Deltaproteobacteria,2MQXX@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
SRR21617310_k127_1024090_0	555079.Toce_1342	8.078e-202	650.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SRR21617310_k127_1024090_1	644966.Tmar_0442	7.439e-51	185.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SRR21617310_k127_1042913_2	42256.RradSPS_1084	2.393e-23	108.0	COG2317@1|root,COG2317@2|Bacteria,2IACE@201174|Actinobacteria,4CPDZ@84995|Rubrobacteria	84995|Rubrobacteria	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
SRR21617310_k127_1042913_4	589924.Ferp_0866	2.829e-07	57.0	arCOG07522@1|root,arCOG07522@2157|Archaea,2Y1I3@28890|Euryarchaeota,247FV@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1042913_3	1220534.B655_0529	1.513e-09	64.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y5SE@28890|Euryarchaeota,23PV0@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1042913_1	457570.Nther_0880	1.053e-38	149.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5
SRR21617310_k127_1042913_0	1189612.A33Q_2393	4.22e-59	207.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,47KDB@768503|Cytophagia	976|Bacteroidetes	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
SRR21617310_k127_1059675_5	985053.VMUT_0385	8.596e-06	49.0	COG0533@1|root,arCOG01185@2157|Archaea,2XQKE@28889|Crenarchaeota	28889|Crenarchaeota	T	Mn2 dependent serine threonine protein kinase	-	-	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	Pkinase,RIO1
SRR21617310_k127_1059675_1	386456.JQKN01000020_gene1319	1.683e-111	371.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
SRR21617310_k127_1059675_4	751944.HALDL1_10950	2.079e-06	55.0	COG1522@1|root,arCOG04153@2157|Archaea,2XX2W@28890|Euryarchaeota,23VIJ@183963|Halobacteria	183963|Halobacteria	K	COG1522 Transcriptional regulators	rpc34	-	-	-	-	-	-	-	-	-	-	-	MarR
SRR21617310_k127_1059675_3	523845.AQXV01000034_gene379	1.658e-57	206.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,23QIM@183939|Methanococci	183939|Methanococci	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
SRR21617310_k127_1059675_2	589924.Ferp_1510	1.719e-80	277.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,246K3@183980|Archaeoglobi	183980|Archaeoglobi	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
SRR21617310_k127_1059675_0	237368.SCABRO_03442	6.388e-135	445.0	COG0046@1|root,COG0046@2|Bacteria,2IXRT@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
SRR21617310_k127_106413_1	1365176.N186_01485	4.779e-32	129.0	COG1208@1|root,arCOG00663@2157|Archaea,2XQ9B@28889|Crenarchaeota	28889|Crenarchaeota	M	COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SRR21617310_k127_106413_3	415426.Hbut_0412	1.375e-12	72.0	COG5625@1|root,arCOG04189@2157|Archaea	2157|Archaea	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_106413_6	1500281.JQKZ01000031_gene2442	8.939e-07	57.0	COG0500@1|root,COG2226@2|Bacteria,4NQGE@976|Bacteroidetes,1IB2S@117743|Flavobacteriia,3ZQRR@59732|Chryseobacterium	976|Bacteroidetes	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR21617310_k127_106413_0	289377.HL41_04740	3.871e-174	555.0	COG0499@1|root,COG0499@2|Bacteria,2GGXJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
SRR21617310_k127_106413_5	1274524.BSONL12_16884	8.702e-11	73.0	COG1522@1|root,COG1522@2|Bacteria,1V1DR@1239|Firmicutes,4HFRT@91061|Bacilli,1ZG22@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	ywrC	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SRR21617310_k127_106413_4	413816.BBJP01000013_gene959	1.657e-11	72.0	COG0529@1|root,arCOG01040@2157|Archaea,2XWW4@28890|Euryarchaeota,23V8B@183963|Halobacteria	183963|Halobacteria	P	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33
SRR21617310_k127_106413_2	324925.Ppha_2251	8.105e-20	95.0	COG0613@1|root,COG0613@2|Bacteria,1FDKZ@1090|Chlorobi	1090|Chlorobi	S	SMART phosphoesterase PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
SRR21617310_k127_1065820_0	386456.JQKN01000001_gene2000	3.014e-59	211.0	arCOG12324@1|root,arCOG12324@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1065820_2	1041930.Mtc_2059	3.945e-21	99.0	COG2193@1|root,arCOG01094@2157|Archaea,2Y22S@28890|Euryarchaeota,2NA49@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferritin-like domain	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SRR21617310_k127_1065820_1	1459636.NTE_01233	3.646e-55	199.0	COG0674@1|root,arCOG01606@2157|Archaea,41S60@651137|Thaumarchaeota	651137|Thaumarchaeota	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
SRR21617310_k127_1070227_7	694430.Natoc_0663	2.644e-42	164.0	COG1402@1|root,arCOG04536@2157|Archaea,2XV07@28890|Euryarchaeota,23U1R@183963|Halobacteria	183963|Halobacteria	H	protein, putative amidase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SRR21617310_k127_1070227_4	393283.XP_007840959.1	2.52e-73	260.0	COG1208@1|root,KOG1322@2759|Eukaryota,38EU6@33154|Opisthokonta,3NTZ3@4751|Fungi,3QM7P@4890|Ascomycota,217U8@147550|Sordariomycetes	4751|Fungi	H	Mannose-1-phosphate guanyltransferase	MPG1	GO:0000032,GO:0003674,GO:0003824,GO:0004475,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006056,GO:0006057,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008905,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009272,GO:0009298,GO:0009653,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019673,GO:0030154,GO:0030435,GO:0031506,GO:0032502,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0043934,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0048646,GO:0048856,GO:0048869,GO:0051286,GO:0055086,GO:0070085,GO:0070568,GO:0070589,GO:0070590,GO:0071554,GO:0071704,GO:0071840,GO:0071852,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SRR21617310_k127_1070227_1	1459636.NTE_02312	2.16e-80	282.0	COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
SRR21617310_k127_1070227_2	386456.JQKN01000002_gene2582	1.109e-77	278.0	COG0677@1|root,arCOG00252@2157|Archaea,2XUJT@28890|Euryarchaeota,23NVR@183925|Methanobacteria	183925|Methanobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SRR21617310_k127_1070227_5	420247.Msm_0882	5.057e-69	246.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,23NSJ@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Oxidoreductase	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SRR21617310_k127_1070227_8	436308.Nmar_0246	4.085e-26	110.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
SRR21617310_k127_1070227_9	573063.Metin_0502	2.09e-07	54.0	COG1996@1|root,arCOG04341@2157|Archaea,2Y26M@28890|Euryarchaeota,23RB9@183939|Methanococci	183939|Methanococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	zf-C2HC5
SRR21617310_k127_1070227_3	192875.XP_004364969.1	4.468e-76	282.0	COG0526@1|root,COG1287@1|root,KOG0191@2759|Eukaryota,KOG2292@2759|Eukaryota,38D8E@33154|Opisthokonta	33154|Opisthokonta	O	subunit of the oligosaccharyltransferase complex	STT3A	GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043686,GO:0043687,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
SRR21617310_k127_1070227_0	1365176.N186_08200	1.534e-131	426.0	arCOG06759@1|root,arCOG06759@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SRR21617310_k127_1070227_6	515635.Dtur_0353	7.715e-43	160.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR21617310_k127_1074778_2	386456.JQKN01000001_gene2131	3.874e-55	199.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,23PIT@183925|Methanobacteria	183925|Methanobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
SRR21617310_k127_1074778_5	868131.MSWAN_1574	1.003e-27	119.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,23P50@183925|Methanobacteria	183925|Methanobacteria	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
SRR21617310_k127_1074778_3	877455.Metbo_2344	9.057e-53	197.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,23NXW@183925|Methanobacteria	183925|Methanobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
SRR21617310_k127_1074778_4	1459636.NTE_00770	4.691e-42	158.0	COG0231@1|root,arCOG04277@2157|Archaea,41SNP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	eIF-5a
SRR21617310_k127_1074778_1	386456.JQKN01000001_gene1642	1.505e-81	282.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,23NS4@183925|Methanobacteria	183925|Methanobacteria	O	Deoxyhypusine synthase	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SRR21617310_k127_1074778_0	186497.PF1731	1.103e-159	515.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
SRR21617310_k127_1080144_1	192952.MM_1237	4.664e-14	79.0	COG0207@1|root,arCOG03214@2157|Archaea,2XYEP@28890|Euryarchaeota,2NBGJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
SRR21617310_k127_1080144_0	525904.Tter_0805	3.208e-157	507.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SRR21617310_k127_1080144_2	1304865.JAGF01000001_gene1631	2.563e-13	78.0	COG0681@1|root,COG0681@2|Bacteria,2IIF5@201174|Actinobacteria	201174|Actinobacteria	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
SRR21617310_k127_1080144_3	453591.Igni_1396	4.144e-07	53.0	arCOG04323@1|root,arCOG04323@2157|Archaea,2XQVX@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_109103_1	439292.Bsel_3146	9.332e-23	102.0	COG1005@1|root,COG1005@2|Bacteria,1TQNU@1239|Firmicutes,4HC8R@91061|Bacilli	91061|Bacilli	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SRR21617310_k127_109103_2	338966.Ppro_0597	7.525e-19	91.0	COG1143@1|root,COG1143@2|Bacteria,1RK71@1224|Proteobacteria,42Y1X@68525|delta/epsilon subdivisions,2WQB3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K14091	-	-	-	-	ko00000	-	-	-	ETF_QO,Fer4,Fer4_7
SRR21617310_k127_109103_4	926569.ANT_22090	1.9e-05	51.0	COG1006@1|root,COG1006@2|Bacteria	2|Bacteria	P	Multisubunit Na H antiporter MnhC subunit	mnhC	-	1.6.5.3	ko:K00340,ko:K05567	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Oxidored_q2
SRR21617310_k127_109103_0	926569.ANT_22080	3.977e-80	292.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi	926569.ANT_22080|-	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_109103_3	379066.GAU_1650	2.681e-17	88.0	COG1008@1|root,COG1008@2|Bacteria,1ZUBB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SRR21617310_k127_1099426_10	1459636.NTE_01818	9.605e-30	124.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
SRR21617310_k127_1099426_4	368408.Tpen_0467	7.666e-71	248.0	COG2519@1|root,arCOG00978@2157|Archaea,2XPU6@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
SRR21617310_k127_1099426_8	572546.Arcpr_1052	6.191e-41	169.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,245ZF@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
SRR21617310_k127_1099426_5	1041930.Mtc_0466	5.123e-62	232.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
SRR21617310_k127_1099426_1	649638.Trad_0944	3.474e-100	344.0	COG0624@1|root,COG0624@2|Bacteria,1WIRQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Peptidase family M20 M25 M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
SRR21617310_k127_1099426_7	1211814.CAPG01000027_gene988	2.531e-43	170.0	COG1235@1|root,COG1235@2|Bacteria,1UWE4@1239|Firmicutes,4IK9H@91061|Bacilli,1ZG1C@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SRR21617310_k127_1099426_0	1283300.ATXB01000001_gene2238	5.225e-103	344.0	COG0826@1|root,COG0826@2|Bacteria,1RHM0@1224|Proteobacteria	1224|Proteobacteria	O	peptidase U32	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1099426_3	368408.Tpen_1222	9.484e-88	299.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPRD@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR21617310_k127_1099426_6	1365176.N186_07280	2.678e-44	171.0	COG0842@1|root,arCOG01467@2157|Archaea,2XQAJ@28889|Crenarchaeota	28889|Crenarchaeota	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRR21617310_k127_1099426_9	490899.DKAM_0964	7.132e-35	143.0	COG0842@1|root,arCOG01467@2157|Archaea,2XPZ5@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRR21617310_k127_1099426_2	342949.PNA2_0394	2.598e-89	310.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
SRR21617310_k127_1101151_1	634498.mru_1826	3.122e-45	169.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23PH1@183925|Methanobacteria	183925|Methanobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SRR21617310_k127_1101151_0	673860.AciM339_1391	4.953e-54	201.0	COG1533@1|root,arCOG01290@2157|Archaea,2XTYE@28890|Euryarchaeota,3F2Z4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SRR21617310_k127_1101151_2	877455.Metbo_1426	5.338e-42	163.0	COG0580@1|root,arCOG04431@2157|Archaea,2XT1N@28890|Euryarchaeota,23P3G@183925|Methanobacteria	183925|Methanobacteria	G	PFAM Major intrinsic protein	-	-	-	ko:K02440	-	-	-	-	ko00000,ko02000	1.A.8.1,1.A.8.2	-	-	MIP
SRR21617310_k127_1101151_3	1380370.JIBA01000010_gene2390	0.0007129	51.0	COG0454@1|root,COG0456@2|Bacteria,2I2W1@201174|Actinobacteria,4FEXW@85021|Intrasporangiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
SRR21617310_k127_1112760_1	1459636.NTE_02505	1.858e-06	54.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_1112760_0	342949.PNA2_0268	1.225e-82	285.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,242XU@183968|Thermococci	183968|Thermococci	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
SRR21617310_k127_112245_7	386456.JQKN01000009_gene1167	4.746e-17	84.0	COG0500@1|root,arCOG02702@2157|Archaea,2XZV2@28890|Euryarchaeota,23PHW@183925|Methanobacteria	183925|Methanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
SRR21617310_k127_112245_2	387631.Asulf_00555	9.423e-62	218.0	arCOG05906@1|root,arCOG05906@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_112245_8	5465.ENH87446	6.941e-05	51.0	KOG1693@1|root,KOG1693@2759|Eukaryota,38GKP@33154|Opisthokonta,3NV0D@4751|Fungi,3QNWN@4890|Ascomycota,215UH@147550|Sordariomycetes,1EXH3@1028384|Glomerellales	4751|Fungi	U	emp24/gp25L/p24 family/GOLD	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005798,GO:0006621,GO:0006810,GO:0006886,GO:0006888,GO:0008104,GO:0008150,GO:0009987,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016192,GO:0030134,GO:0030135,GO:0031224,GO:0031410,GO:0031982,GO:0032507,GO:0033036,GO:0033365,GO:0034613,GO:0035437,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0045184,GO:0045185,GO:0046907,GO:0048193,GO:0051179,GO:0051234,GO:0051235,GO:0051641,GO:0051649,GO:0051651,GO:0065007,GO:0065008,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0072595,GO:0097708	-	ko:K14825	-	-	-	-	ko00000,ko02000,ko03009,ko04131	9.B.188	-	-	EMP24_GP25L
SRR21617310_k127_112245_4	591019.Shell_0337	4.814e-27	114.0	COG4900@1|root,arCOG04217@2157|Archaea,2XQUZ@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_112245_0	1220534.B655_1154	1.127e-127	432.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23NU1@183925|Methanobacteria	183925|Methanobacteria	P	heavy metal-(Cd Co Hg Pb Zn)-translocating	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
SRR21617310_k127_112245_5	1132509.C447_15106	6.818e-24	106.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,23V9I@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
SRR21617310_k127_112245_1	1191523.MROS_2233	2.201e-116	385.0	COG0205@1|root,COG0205@2|Bacteria	2|Bacteria	G	6-phosphofructokinase activity	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SRR21617310_k127_112245_6	694429.Pyrfu_1801	1.451e-23	105.0	COG0517@1|root,arCOG00606@2157|Archaea,2XR8I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR21617310_k127_112245_3	309801.trd_A0619	1.704e-35	137.0	COG4274@1|root,COG4274@2|Bacteria,2GBAJ@200795|Chloroflexi,27YIF@189775|Thermomicrobia	189775|Thermomicrobia	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
SRR21617310_k127_1134823_2	1184251.TCELL_0961	4.012e-06	53.0	COG1392@1|root,arCOG02640@2157|Archaea,2XQJ3@28889|Crenarchaeota	28889|Crenarchaeota	P	phosphate transport	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SRR21617310_k127_1134823_1	591019.Shell_0778	2.627e-07	59.0	COG1392@1|root,arCOG02640@2157|Archaea,2XQJ3@28889|Crenarchaeota	28889|Crenarchaeota	P	phosphate transport	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SRR21617310_k127_1134823_0	289376.THEYE_A1498	1.432e-89	304.0	COG2509@1|root,COG2509@2|Bacteria	2|Bacteria	H	5-formyltetrahydrofolate cyclo-ligase activity	IV02_08645	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2
SRR21617310_k127_115120_0	1121405.dsmv_2845	1.938e-186	597.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42PXA@68525|delta/epsilon subdivisions,2WM6E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
SRR21617310_k127_115120_1	555088.DealDRAFT_0489	4.999e-155	508.0	COG3387@1|root,COG3387@2|Bacteria,1TR12@1239|Firmicutes,248Q3@186801|Clostridia,42KAA@68298|Syntrophomonadaceae	186801|Clostridia	G	PFAM glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
SRR21617310_k127_1152029_3	1158760.AQXP01000026_gene20	0.0005921	45.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,1P5B8@1224|Proteobacteria	1224|Proteobacteria	S	Haloacid dehalogenase domain protein hydrolase, type 3	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
SRR21617310_k127_1152029_2	661478.OP10G_4468	3.247e-10	66.0	2DSJI@1|root,33GEP@2|Bacteria	2|Bacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
SRR21617310_k127_1152029_1	649638.Trad_1629	6.942e-27	125.0	28J3E@1|root,2Z8ZN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1152029_0	1365176.N186_07575	1.555e-42	167.0	COG0747@1|root,arCOG01534@2157|Archaea,2XPZY@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRR21617310_k127_11550_0	391623.TERMP_00522	2.884e-99	331.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,243CK@183968|Thermococci	183968|Thermococci	J	Cysteinyl-tRNA synthetase	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
SRR21617310_k127_11550_1	234267.Acid_7473	2.339e-78	271.0	COG1028@1|root,COG1028@2|Bacteria,3Y4CZ@57723|Acidobacteria	57723|Acidobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRR21617310_k127_11550_2	930945.SiRe_0264	7.156e-08	57.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_11550_3	330779.Saci_1125	8.929e-08	53.0	COG1225@1|root,arCOG00310@2157|Archaea,2XQPI@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SRR21617310_k127_1166826_2	1365176.N186_03840	3.415e-44	163.0	COG1358@1|root,arCOG01751@2157|Archaea,2XQH4@28889|Crenarchaeota	28889|Crenarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
SRR21617310_k127_1166826_4	591019.Shell_1641	1.248e-24	105.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
SRR21617310_k127_1166826_5	330779.Saci_0697	2.074e-20	91.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
SRR21617310_k127_1166826_3	368408.Tpen_1041	7.968e-32	130.0	COG0494@1|root,arCOG01074@2157|Archaea,2XS5U@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM NUDIX hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
SRR21617310_k127_1166826_1	351627.Csac_2267	1.732e-62	221.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,42ES7@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
SRR21617310_k127_1166826_0	399550.Smar_0829	3.727e-209	666.0	COG0532@1|root,arCOG01560@2157|Archaea,2XPQ5@28889|Crenarchaeota	28889|Crenarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
SRR21617310_k127_1176890_2	1094980.Mpsy_1403	7.522e-67	234.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
SRR21617310_k127_1176890_3	443143.GM18_2743	3.123e-46	181.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
SRR21617310_k127_1176890_1	386456.JQKN01000001_gene2139	1.69e-72	255.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT1I@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR21617310_k127_1176890_0	1089547.KB913013_gene3819	3.039e-94	314.0	COG0154@1|root,COG0154@2|Bacteria,4NF8C@976|Bacteroidetes,47MMB@768503|Cytophagia	976|Bacteroidetes	J	Amidase	gatA	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
SRR21617310_k127_1180370_3	643648.Slip_2104	1.163e-15	77.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,42KH4@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
SRR21617310_k127_1180370_4	1132509.C447_05782	0.0003759	49.0	COG4190@1|root,arCOG02756@2157|Archaea,2XZKX@28890|Euryarchaeota,23WZP@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1180370_2	1343739.PAP_02785	3.999e-34	136.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,242RW@183968|Thermococci	183968|Thermococci	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360	-	-	-	-	-	-	-	-	-	-	Archease
SRR21617310_k127_1180370_0	580331.Thit_2179	3.917e-201	637.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
SRR21617310_k127_1180370_1	264732.Moth_1518	4.484e-73	252.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,42EK7@68295|Thermoanaerobacterales	186801|Clostridia	C	Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain	nfnA	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
SRR21617310_k127_1190893_1	1220534.B655_2010	1.839e-44	180.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,23NN7@183925|Methanobacteria	183925|Methanobacteria	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
SRR21617310_k127_1190893_4	1459636.NTE_01468	5.311e-08	56.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
SRR21617310_k127_1190893_0	1459636.NTE_03553	8.86e-186	589.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SRR21617310_k127_1190893_3	795359.TOPB45_0855	2.138e-28	120.0	COG5483@1|root,COG5483@2|Bacteria,2GI0U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
SRR21617310_k127_1190893_2	1042877.GQS_00910	8.933e-32	126.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,244B1@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
SRR21617310_k127_1206780_1	374847.Kcr_0387	1.915e-16	87.0	arCOG03119@1|root,arCOG03119@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SRR21617310_k127_1206780_3	4006.Lus10042189	1.587e-05	55.0	KOG1940@1|root,KOG1940@2759|Eukaryota,37KUN@33090|Viridiplantae,3GH0A@35493|Streptophyta,4JK3F@91835|fabids	35493|Streptophyta	O	CHY zinc finger	-	GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010498,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0019941,GO:0030003,GO:0030163,GO:0031667,GO:0031668,GO:0031669,GO:0032446,GO:0033554,GO:0036211,GO:0042592,GO:0042594,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051603,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0070647,GO:0071496,GO:0071704,GO:0098771,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K16276	-	-	-	-	ko00000,ko04121	-	-	-	Hemerythrin,zf-CHY,zf-RING_2,zinc_ribbon_6
SRR21617310_k127_1206780_2	255470.cbdbA1472	5.616e-10	67.0	COG0716@1|root,COG0716@2|Bacteria,2GAZ4@200795|Chloroflexi,34DME@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1206780_0	224324.aq_403	2.111e-47	175.0	COG1856@1|root,COG1856@2|Bacteria	2|Bacteria	S	radical SAM domain protein	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
SRR21617310_k127_1230223_0	1459636.NTE_00392	6.752e-42	165.0	COG0467@1|root,arCOG01174@2157|Archaea	2157|Archaea	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SRR21617310_k127_1230223_1	1227488.C477_10378	5.26e-05	55.0	COG2203@1|root,arCOG03567@1|root,arCOG02369@2157|Archaea,arCOG03567@2157|Archaea,2XUM1@28890|Euryarchaeota,23UN4@183963|Halobacteria	183963|Halobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS
SRR21617310_k127_1230223_2	1410674.JNKU01000004_gene1834	0.0001368	47.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4HC4H@91061|Bacilli,3F43H@33958|Lactobacillaceae	91061|Bacilli	D	Alpha beta	ybcH	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,Hydrolase_4
SRR21617310_k127_1254319_3	374847.Kcr_1342	2.276e-21	97.0	COG1208@1|root,arCOG05599@2157|Archaea	2157|Archaea	JM	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_4
SRR21617310_k127_1254319_0	666510.ASAC_0410	3.63e-56	209.0	COG0017@1|root,arCOG00407@2157|Archaea,2XQ0M@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (D, K and N)	-	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SRR21617310_k127_1254319_1	192952.MM_1299	3.466e-36	152.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
SRR21617310_k127_1254319_5	69014.TK1812	1.208e-08	60.0	COG2034@1|root,arCOG02717@2157|Archaea,2Y15K@28890|Euryarchaeota,244Q8@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF131	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
SRR21617310_k127_1254319_7	1151117.AJLF01000002_gene163	0.0001036	50.0	COG2034@1|root,arCOG02717@2157|Archaea,2Y15K@28890|Euryarchaeota,244Q8@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF131	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
SRR21617310_k127_1254319_4	436308.Nmar_1083	5.085e-10	66.0	COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1254319_2	192952.MM_0261	3.285e-28	120.0	COG0426@1|root,arCOG00509@2157|Archaea,2XYDW@28890|Euryarchaeota,2N9PY@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
SRR21617310_k127_1255215_1	86416.Clopa_0047	6.597e-189	610.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,36GCY@31979|Clostridiaceae	186801|Clostridia	Q	PFAM Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
SRR21617310_k127_1255215_0	694429.Pyrfu_0295	2.684e-254	806.0	COG0417@1|root,arCOG00328@2157|Archaea,2XPM8@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM DNA polymerase (pol2)	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
SRR21617310_k127_1273760_2	443144.GM21_2431	0.0001086	53.0	COG1572@1|root,COG1657@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG4733@1|root,COG1572@2|Bacteria,COG1657@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,1MWIT@1224|Proteobacteria,42W2M@68525|delta/epsilon subdivisions,2WRTW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,VCBS
SRR21617310_k127_1273760_1	591019.Shell_1011	2.113e-62	229.0	COG1136@1|root,arCOG00922@2157|Archaea,2XQ2I@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR21617310_k127_1273760_0	1220534.B655_1873	4.677e-95	320.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,23NN6@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
SRR21617310_k127_1277463_4	374847.Kcr_1094	1.199e-98	333.0	COG0601@1|root,arCOG00751@2157|Archaea	2157|Archaea	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SRR21617310_k127_1277463_2	374847.Kcr_1095	4.135e-117	384.0	COG1173@1|root,arCOG00748@2157|Archaea	2157|Archaea	P	COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SRR21617310_k127_1277463_3	1499967.BAYZ01000006_gene5459	5.037e-106	356.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SRR21617310_k127_1277463_0	374847.Kcr_1097	9.001e-130	423.0	COG4608@1|root,arCOG00184@2157|Archaea	2157|Archaea	E	COG4608 ABC-type oligopeptide transport system, ATPase component	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SRR21617310_k127_1277463_1	374847.Kcr_1093	4.34e-118	407.0	COG0747@1|root,arCOG01534@2157|Archaea	2157|Archaea	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRR21617310_k127_1277463_5	931276.Cspa_c18570	0.000666	50.0	COG2911@1|root,COG2911@2|Bacteria,1VPE0@1239|Firmicutes,24EBU@186801|Clostridia,36FS9@31979|Clostridiaceae	186801|Clostridia	N	cellulosome anchoring protein cohesin region	cipA	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CBM_X2,CarboxypepD_reg,Cohesin
SRR21617310_k127_1282729_0	1047013.AQSP01000142_gene241	1.072e-123	407.0	COG0252@1|root,COG0252@2|Bacteria,2NPMK@2323|unclassified Bacteria	2|Bacteria	EJ	Asparaginase	ansA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
SRR21617310_k127_1282729_1	453591.Igni_0077	7.608e-100	349.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
SRR21617310_k127_1282729_3	331869.BAL199_26077	9.638e-06	51.0	COG1522@1|root,COG1522@2|Bacteria,1MZDV@1224|Proteobacteria,2UBTU@28211|Alphaproteobacteria,4BSXY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Lrp/AsnC ligand binding domain	QU41_18010	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SRR21617310_k127_1282729_2	351160.RCIX1020	1.226e-55	206.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
SRR21617310_k127_1287079_9	593750.Metfor_0301	0.0001318	46.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2N93G@224756|Methanomicrobia	224756|Methanomicrobia	N	type II secretion system protein	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SRR21617310_k127_1287079_6	694440.JOMF01000005_gene106	6.715e-33	138.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,2NAP1@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SRR21617310_k127_1287079_7	374847.Kcr_0566	1.31e-31	136.0	COG2888@1|root,arCOG06883@1|root,arCOG01989@2157|Archaea,arCOG06883@2157|Archaea	2157|Archaea	J	Zn-ribbon RNA-binding protein with a function in translation	-	-	-	-	-	-	-	-	-	-	-	-	DUF2334
SRR21617310_k127_1287079_4	877455.Metbo_0811	3.581e-46	171.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
SRR21617310_k127_1287079_5	1343739.PAP_01915	2.865e-36	142.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
SRR21617310_k127_1287079_8	573064.Mefer_0486	1.144e-30	124.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,23R1N@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
SRR21617310_k127_1287079_0	591019.Shell_1652	1.827e-68	242.0	COG0202@1|root,arCOG04241@2157|Archaea,2XQ0D@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
SRR21617310_k127_1287079_2	1343739.PAP_01895	1.203e-55	198.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,243ZQ@183968|Thermococci	183968|Thermococci	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
SRR21617310_k127_1287079_1	591019.Shell_1654	3.111e-57	205.0	COG0522@1|root,arCOG04239@2157|Archaea,2XQCT@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
SRR21617310_k127_1287079_3	399550.Smar_0812	3.156e-50	183.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
SRR21617310_k127_1314567_2	1173023.KE650771_gene2305	3.623e-14	74.0	COG1801@1|root,COG1801@2|Bacteria,1G2CT@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG1801 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SRR21617310_k127_1314567_1	1459636.NTE_00004	2.579e-22	106.0	COG0468@1|root,arCOG00415@2157|Archaea	2157|Archaea	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	-	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
SRR21617310_k127_1314567_3	880072.Desac_2172	3.321e-10	64.0	arCOG07300@1|root,2ZTGG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1314567_0	1459636.NTE_00007	1.401e-181	594.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
SRR21617310_k127_1314567_4	457424.BFAG_03976	0.0007658	47.0	COG1216@1|root,COG1216@2|Bacteria,4NKPU@976|Bacteroidetes,2FQ38@200643|Bacteroidia,4ANSY@815|Bacteroidaceae	976|Bacteroidetes	S	Glycosyltransferase, group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8,Glycos_transf_2
SRR21617310_k127_1320376_5	444157.Tneu_1641	6.023e-09	57.0	COG1552@1|root,arCOG04049@2157|Archaea,2XRHJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
SRR21617310_k127_1320376_1	1463934.JOCF01000006_gene6427	2.397e-23	107.0	COG1670@1|root,COG1670@2|Bacteria,2INDG@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.82	ko:K00663	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Acetyltransf_3
SRR21617310_k127_1320376_2	633148.Tagg_0263	1.111e-19	102.0	arCOG07686@1|root,arCOG07686@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1320376_3	269797.Mbar_A1175	2.236e-17	94.0	COG0785@1|root,arCOG02404@2157|Archaea,2Y7HT@28890|Euryarchaeota,2NA19@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
SRR21617310_k127_1320376_4	330214.NIDE0629	1.873e-09	65.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	yneN	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRR21617310_k127_1320376_0	323259.Mhun_1311	1.54e-72	247.0	COG1592@1|root,arCOG01097@2157|Archaea,2XWSA@28890|Euryarchaeota,2NBII@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Rubrerythrin	rbr-1	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SRR21617310_k127_1342668_0	1410653.JHVC01000002_gene4281	3.705e-176	565.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
SRR21617310_k127_1342668_1	1408422.JHYF01000017_gene1857	4.714e-95	323.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,36EKF@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SRR21617310_k127_1342668_2	1499967.BAYZ01000069_gene1849	6.993e-84	286.0	COG1079@1|root,COG1079@2|Bacteria	2|Bacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
SRR21617310_k127_1352478_1	608538.HTH_0269	1.939e-84	295.0	COG1215@1|root,COG1215@2|Bacteria,2G4H2@200783|Aquificae	200783|Aquificae	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
SRR21617310_k127_1352478_13	273057.SSO6817	4.68e-11	64.0	COG4919@1|root,arCOG04293@2157|Archaea,2XR5C@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Ribosomal protein S30	-	-	-	ko:K02983	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04121	-	-	-	Ribosomal_S30
SRR21617310_k127_1352478_2	926569.ANT_26780	2.946e-64	228.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRR21617310_k127_1352478_3	186497.PF0752	1.616e-61	215.0	COG1225@1|root,arCOG00310@2157|Archaea,2XY0E@28890|Euryarchaeota,2440M@183968|Thermococci	183968|Thermococci	O	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
SRR21617310_k127_1352478_10	697303.Thewi_0157	2.303e-13	75.0	COG0394@1|root,COG0698@1|root,COG0394@2|Bacteria,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,42GC5@68295|Thermoanaerobacterales	186801|Clostridia	G	ribose 5-phosphate isomerase B	ywlF	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,LacAB_rpiB
SRR21617310_k127_1352478_6	289376.THEYE_A0743	6.385e-21	96.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
SRR21617310_k127_1352478_5	323259.Mhun_3201	1.47e-21	98.0	COG0745@1|root,arCOG02595@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
SRR21617310_k127_1352478_9	1131730.BAVI_07024	8.958e-17	96.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4HD4A@91061|Bacilli,1ZARI@1386|Bacillus	91061|Bacilli	T	COG0642 Signal transduction histidine kinase	kinE	-	2.7.13.3	ko:K13533	ko02020,map02020	M00485	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,dCache_1
SRR21617310_k127_1352478_0	192952.MM_0168	1.165e-103	376.0	COG2203@1|root,arCOG02350@1|root,arCOG02352@1|root,arCOG03567@1|root,arCOG04000@1|root,arCOG02350@2157|Archaea,arCOG02352@2157|Archaea,arCOG02356@2157|Archaea,arCOG02361@2157|Archaea,arCOG03567@2157|Archaea,arCOG04000@2157|Archaea,2Y7MY@28890|Euryarchaeota,2NAHA@224756|Methanomicrobia	224756|Methanomicrobia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_2,PAS_3,PAS_4,PAS_9
SRR21617310_k127_1352478_7	351160.RCIX90	1.867e-20	106.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
SRR21617310_k127_1352478_15	387631.Asulf_02179	2.611e-07	63.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,24692@183980|Archaeoglobi	183980|Archaeoglobi	S	signal transduction protein with CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR21617310_k127_1352478_8	1397666.RS24_01960	9.9e-18	85.0	2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,2U8PC@28211|Alphaproteobacteria,4BRYT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1352478_19	3712.Bo01661s030.1	0.0008714	46.0	2E8JE@1|root,2SF1C@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1352478_12	498761.HM1_3125	1.721e-11	68.0	2DSV3@1|root,33HII@2|Bacteria,1VQ64@1239|Firmicutes,24VWA@186801|Clostridia	186801|Clostridia	S	ORF located using Blastx	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1367718_4	573063.Metin_0058	9.77e-86	294.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
SRR21617310_k127_1367718_11	666510.ASAC_0183	4.666e-08	56.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
SRR21617310_k127_1367718_3	186497.PF1912	2.743e-100	342.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,243CJ@183968|Thermococci	183968|Thermococci	J	methylthiotransferase activity	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
SRR21617310_k127_1367718_6	744872.Spica_1727	1.282e-56	207.0	COG0095@1|root,COG0095@2|Bacteria,2J7CV@203691|Spirochaetes	203691|Spirochaetes	H	Lipoate-protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
SRR21617310_k127_1367718_9	1459636.NTE_01618	1.805e-23	104.0	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
SRR21617310_k127_1367718_0	1121403.AUCV01000020_gene3109	5.34e-258	820.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
SRR21617310_k127_1367718_7	351160.RRC254	2.164e-42	168.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
SRR21617310_k127_1367718_1	1054217.TALC_01492	6.178e-118	389.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,241W7@183967|Thermoplasmata	183967|Thermoplasmata	O	AIR synthase related protein, C-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
SRR21617310_k127_1367718_2	420247.Msm_0945	3.04e-115	381.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,23NRS@183925|Methanobacteria	183925|Methanobacteria	O	hydrogenase expression formation protein	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
SRR21617310_k127_1367718_8	1236689.MMALV_11500	2.696e-29	120.0	COG0375@1|root,arCOG04426@2157|Archaea,2XYBI@28890|Euryarchaeota,3F2U7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
SRR21617310_k127_1367718_5	573063.Metin_0655	1.083e-64	228.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,23QIT@183939|Methanococci	183939|Methanococci	O	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
SRR21617310_k127_1367718_10	1343739.PAP_06290	5.698e-19	88.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,244KI@183968|Thermococci	183968|Thermococci	O	HupF/HypC family	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
SRR21617310_k127_1369475_0	1459636.NTE_00462	2.58e-31	131.0	COG0455@1|root,arCOG00589@2157|Archaea	2157|Archaea	D	COG0455 ATPases involved in chromosome partitioning	-	-	-	ko:K03496,ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
SRR21617310_k127_1369475_4	31964.CMS1280	0.0009931	51.0	COG0477@1|root,COG0477@2|Bacteria,2GIYR@201174|Actinobacteria,4FKXX@85023|Microbacteriaceae	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
SRR21617310_k127_1369475_1	386456.JQKN01000001_gene1715	5.449e-28	128.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,23NK4@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SRR21617310_k127_1369475_2	1476876.JOJO01000002_gene6307	2.389e-10	66.0	COG1695@1|root,COG1695@2|Bacteria,2GRHC@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
SRR21617310_k127_1369475_3	523850.TON_0011	6.28e-10	66.0	COG1695@1|root,arCOG00001@2157|Archaea,2XZNT@28890|Euryarchaeota,244GG@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SRR21617310_k127_1385983_2	658187.LDG_5974	8.036e-46	175.0	COG1108@1|root,COG1108@2|Bacteria,1QBYD@1224|Proteobacteria,1T7JM@1236|Gammaproteobacteria,1JFGH@118969|Legionellales	118969|Legionellales	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
SRR21617310_k127_1385983_1	661367.LLO_2971	8.253e-54	197.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1JFVA@118969|Legionellales	118969|Legionellales	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
SRR21617310_k127_1385983_0	720554.Clocl_0441	1.455e-55	203.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR21617310_k127_13875_4	264732.Moth_0729	1.586e-30	137.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,42EKW@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SRR21617310_k127_13875_7	391626.OAN307_c45120	1.058e-11	75.0	COG2227@1|root,COG2227@2|Bacteria,1PSNI@1224|Proteobacteria,2TV3H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	3-demethylubiquinone-9 3-methyltransferase	ubiG2	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
SRR21617310_k127_13875_0	234267.Acid_4865	1.504e-120	392.0	COG1809@1|root,COG1809@2|Bacteria	2|Bacteria	S	phosphosulfolactate synthase activity	comA	-	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	ComA
SRR21617310_k127_13875_2	234267.Acid_4866	1.385e-71	248.0	COG2045@1|root,COG2045@2|Bacteria	2|Bacteria	H	2-phosphosulfolactate phosphatase activity	comB	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
SRR21617310_k127_13875_1	234267.Acid_4867	2.738e-120	399.0	COG3919@1|root,COG3919@2|Bacteria	2|Bacteria	E	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2
SRR21617310_k127_13875_3	374847.Kcr_0849	1.226e-66	247.0	COG2244@1|root,arCOG02209@2157|Archaea	2157|Archaea	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
SRR21617310_k127_13875_8	386456.JQKN01000008_gene1348	4.27e-09	65.0	COG4743@1|root,arCOG02879@1|root,arCOG10449@1|root,arCOG02879@2157|Archaea,arCOG02884@2157|Archaea,arCOG10449@2157|Archaea,2XU3K@28890|Euryarchaeota,23PY1@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF1616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1616
SRR21617310_k127_13875_5	1104324.P186_2053	2.77e-26	115.0	COG4743@1|root,arCOG02887@2157|Archaea,2XQK6@28889|Crenarchaeota	28889|Crenarchaeota	S	COGs COG4743 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1616
SRR21617310_k127_1408864_1	573063.Metin_0721	6.321e-35	137.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23QSQ@183939|Methanococci	183939|Methanococci	J	SMART KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
SRR21617310_k127_1408864_0	374847.Kcr_1451	1.833e-139	458.0	COG1389@1|root,arCOG01165@2157|Archaea	2157|Archaea	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
SRR21617310_k127_1419828_3	555079.Toce_0632	4.066e-43	169.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,42GS6@68295|Thermoanaerobacterales	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRR21617310_k127_1419828_0	399550.Smar_0907	1.714e-216	684.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPYR@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsB	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR21617310_k127_1419828_8	593117.TGAM_1780	9.321e-15	76.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
SRR21617310_k127_1419828_2	1042877.GQS_04200	3.37e-43	171.0	arCOG11292@1|root,arCOG11292@2157|Archaea,2Y3FT@28890|Euryarchaeota,2443S@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1419828_4	1511.CLOST_0465	4.59e-37	149.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,25SSI@186804|Peptostreptococcaceae	186801|Clostridia	L	TatD related DNase	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
SRR21617310_k127_1419828_5	1201290.M902_0453	1.565e-25	108.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42TQU@68525|delta/epsilon subdivisions,2MTFS@213481|Bdellovibrionales,2WQ3A@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	Peptidyl-prolyl cis-trans isomerase	ppiC	-	5.2.1.8	ko:K01802,ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SseB
SRR21617310_k127_1419828_9	186497.PF1491	7.884e-12	68.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,244GA@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
SRR21617310_k127_1419828_1	633148.Tagg_1147	8.071e-50	189.0	COG1475@1|root,arCOG01875@2157|Archaea,2XR7V@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM ParB domain protein nuclease	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
SRR21617310_k127_1419828_10	523841.HFX_2236	4.266e-08	58.0	COG1977@1|root,arCOG00536@2157|Archaea,2XYQA@28890|Euryarchaeota,23WPF@183963|Halobacteria	183963|Halobacteria	H	COG1977 Molybdopterin converting factor, small subunit	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SRR21617310_k127_1419828_6	65497.JODV01000014_gene3384	2.978e-21	107.0	COG2234@1|root,COG2234@2|Bacteria,2GIT0@201174|Actinobacteria,4DY8W@85010|Pseudonocardiales	201174|Actinobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
SRR21617310_k127_1419828_7	304371.MCP_1813	3.647e-16	83.0	COG0607@1|root,arCOG02021@2157|Archaea	2157|Archaea	P	COG0607 Rhodanese-related sulfurtransferase	-	-	2.8.1.11	ko:K03406,ko:K21028	ko02020,ko02030,ko04122,map02020,map02030,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko02035	-	-	-	MCPsignal,Pyr_redox_2,Pyr_redox_dim,Rhodanese
SRR21617310_k127_1437009_4	1121422.AUMW01000038_gene3024	1.648e-36	141.0	COG1941@1|root,COG1941@2|Bacteria,1V21E@1239|Firmicutes,24GWD@186801|Clostridia,264VD@186807|Peptococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
SRR21617310_k127_1437009_0	1379698.RBG1_1C00001G0047	4.735e-207	653.0	COG3259@1|root,COG3259@2|Bacteria,2NQGS@2323|unclassified Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
SRR21617310_k127_1437009_1	304371.MCP_2633	3.842e-129	420.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR21617310_k127_1437009_3	868131.MSWAN_1381	6.2e-48	176.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRR21617310_k127_1445632_5	401526.TcarDRAFT_2440	2.043e-33	134.0	COG3875@1|root,COG3875@2|Bacteria,1TUCQ@1239|Firmicutes,4H66I@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
SRR21617310_k127_1445632_0	269797.Mbar_A2103	4.253e-185	608.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SRR21617310_k127_1445632_7	1236689.MMALV_07520	2.835e-06	58.0	arCOG03450@1|root,arCOG03450@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF553
SRR21617310_k127_1445632_9	1437609.BCAL_0447	6.088e-06	55.0	COG3247@1|root,COG3247@2|Bacteria,2H3AT@201174|Actinobacteria,4D00R@85004|Bifidobacteriales	201174|Actinobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
SRR21617310_k127_1445632_1	1094980.Mpsy_3144	2.554e-97	324.0	COG4803@1|root,arCOG09748@1|root,arCOG05227@2157|Archaea,arCOG09748@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1269)	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	-
SRR21617310_k127_1445632_4	1459636.NTE_03027	1.689e-36	145.0	arCOG08805@1|root,arCOG08805@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1445632_8	1279015.KB908464_gene2118	4.126e-06	54.0	COG0668@1|root,COG0668@2|Bacteria,1QU7U@1224|Proteobacteria,1T1Q9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Mechanosensitive Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
SRR21617310_k127_1445632_3	1094980.Mpsy_3144	5.111e-65	233.0	COG4803@1|root,arCOG09748@1|root,arCOG05227@2157|Archaea,arCOG09748@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1269)	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	-
SRR21617310_k127_1445632_6	387631.Asulf_00452	2.283e-21	95.0	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
SRR21617310_k127_1445632_2	304371.MCP_2139	1.094e-80	276.0	COG3369@1|root,arCOG03174@2157|Archaea,2XX0Q@28890|Euryarchaeota,2NAIG@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART zinc finger, CDGSH-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
SRR21617310_k127_1449445_1	477974.Daud_1323	8.166e-10	61.0	COG1085@1|root,COG1085@2|Bacteria,1TS3F@1239|Firmicutes,249P3@186801|Clostridia,2602F@186807|Peptococcaceae	186801|Clostridia	H	Galactose-1-phosphate uridyl transferase, C-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,DUF4931,GalP_UDP_tr_C,GalP_UDP_transf
SRR21617310_k127_1449445_0	693661.Arcve_1221	5.286e-137	448.0	COG0438@1|root,arCOG01403@2157|Archaea,2Y8B9@28890|Euryarchaeota	28890|Euryarchaeota	M	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR21617310_k127_1449445_2	565033.GACE_0348	2.025e-05	51.0	arCOG03924@1|root,arCOG03924@2157|Archaea,2Y4ZM@28890|Euryarchaeota,247B9@183980|Archaeoglobi	183980|Archaeoglobi	K	IclR helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_146181_3	456442.Mboo_1043	3.822e-68	242.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2N996@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
SRR21617310_k127_146181_1	374847.Kcr_0965	2.123e-80	281.0	COG1748@1|root,arCOG00243@2157|Archaea	2157|Archaea	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP,Semialdhyde_dh,UDPG_MGDP_dh_N
SRR21617310_k127_146181_0	1047013.AQSP01000134_gene1338	5.79e-122	408.0	COG5598@1|root,COG5598@2|Bacteria,2NQTC@2323|unclassified Bacteria	2|Bacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SRR21617310_k127_146181_7	604354.TSIB_1440	9.418e-06	58.0	COG3368@1|root,arCOG02444@2157|Archaea,2XWVI@28890|Euryarchaeota,243A0@183968|Thermococci	183968|Thermococci	S	Membrane protein of 12 TMs	-	-	-	ko:K07087	-	-	-	-	ko00000	-	-	-	12TM_1
SRR21617310_k127_146181_2	1183377.Py04_0967	1.35e-71	251.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,243M3@183968|Thermococci	183968|Thermococci	E	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR21617310_k127_146181_6	452652.KSE_69510	3.812e-12	74.0	COG4894@1|root,COG4894@2|Bacteria,2GKWI@201174|Actinobacteria,2M2WE@2063|Kitasatospora	201174|Actinobacteria	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
SRR21617310_k127_146181_5	1266845.Q783_08170	2.008e-16	85.0	COG0346@1|root,COG0346@2|Bacteria,1V6K3@1239|Firmicutes,4HJ7X@91061|Bacilli,27GGJ@186828|Carnobacteriaceae	91061|Bacilli	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759,ko:K15772	ko00620,ko02010,map00620,map02010	M00491	R02530	RC00004,RC00740	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	Glyoxalase
SRR21617310_k127_146181_4	224325.AF_0892	3.602e-34	141.0	COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,2470I@183980|Archaeoglobi	183980|Archaeoglobi	S	NADPH-dependent F420 reductase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
SRR21617310_k127_1466932_0	351160.RRC440	5.379e-145	469.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2NADJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF650	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
SRR21617310_k127_1466932_2	591019.Shell_1147	2e-54	200.0	COG1637@1|root,arCOG01304@2157|Archaea,2XQ7Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
SRR21617310_k127_1466932_4	1121939.L861_01770	6.308e-14	79.0	COG0500@1|root,COG2226@2|Bacteria,1R6F0@1224|Proteobacteria,1RXR4@1236|Gammaproteobacteria,1XQKX@135619|Oceanospirillales	135619|Oceanospirillales	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR21617310_k127_1466932_1	933262.AXAM01000010_gene1371	1.054e-92	321.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
SRR21617310_k127_1466932_3	1343739.PAP_06275	5.392e-43	165.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,242WT@183968|Thermococci	183968|Thermococci	M	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
SRR21617310_k127_1502670_5	515635.Dtur_0011	1.125e-30	126.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SRR21617310_k127_1502670_4	479434.Sthe_1772	1.743e-53	196.0	COG1028@1|root,COG1028@2|Bacteria,2G8JD@200795|Chloroflexi,27YCF@189775|Thermomicrobia	189775|Thermomicrobia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
SRR21617310_k127_1502670_0	335543.Sfum_4051	5.35e-138	450.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
SRR21617310_k127_1502670_1	192952.MM_2876	6.253e-99	335.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
SRR21617310_k127_1502670_7	78344.BIGA_1591	1.289e-06	53.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria,4D1AW@85004|Bifidobacteriales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SRR21617310_k127_1502670_2	439235.Dalk_2354	1.029e-90	313.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,42PSQ@68525|delta/epsilon subdivisions,2WKDY@28221|Deltaproteobacteria,2MK85@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
SRR21617310_k127_1502670_3	1459636.NTE_01764	1.417e-57	205.0	COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
SRR21617310_k127_1502670_6	1459636.NTE_01763	1.126e-21	103.0	COG1392@1|root,arCOG02640@2157|Archaea,41SGI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SRR21617310_k127_1502670_8	273057.SSO0580	0.0008576	48.0	COG4996@1|root,arCOG04046@2157|Archaea,2XR0K@28889|Crenarchaeota	28889|Crenarchaeota	S	HAD-superfamily phosphatase, subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	Acid_PPase
SRR21617310_k127_1521622_2	593117.TGAM_0393	3.286e-08	64.0	COG0454@1|root,arCOG00826@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_9
SRR21617310_k127_1529053_3	913865.DOT_6258	0.0004857	43.0	COG0451@1|root,COG0451@2|Bacteria,1U9KB@1239|Firmicutes,24EDU@186801|Clostridia	186801|Clostridia	GM	PFAM NAD dependent epimerase dehydratase family	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SRR21617310_k127_1529053_0	387631.Asulf_00031	7.021e-146	469.0	COG0451@1|root,arCOG01372@2157|Archaea,2XVFK@28890|Euryarchaeota	28890|Euryarchaeota	M	Epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SRR21617310_k127_1529053_2	457570.Nther_2530	6.295e-41	164.0	COG4447@1|root,COG4447@2|Bacteria,1UKJF@1239|Firmicutes	1239|Firmicutes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1529053_1	1131266.ARWQ01000003_gene1559	2.501e-68	241.0	COG0726@1|root,arCOG02876@2157|Archaea	2157|Archaea	G	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
SRR21617310_k127_1535032_2	1499967.BAYZ01000188_gene3884	2.058e-13	75.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
SRR21617310_k127_1535032_0	387631.Asulf_01683	9.61e-30	123.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,246C8@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
SRR21617310_k127_1535032_3	1041930.Mtc_1680	7.065e-09	63.0	arCOG00764@1|root,arCOG00764@2157|Archaea,2Y49B@28890|Euryarchaeota,2NAZ2@224756|Methanomicrobia	224756|Methanomicrobia	C	formylmethanofuran dehydrogenase, subunit E	-	-	-	-	-	-	-	-	-	-	-	-	FmdE
SRR21617310_k127_1535032_1	293826.Amet_1218	7.866e-23	103.0	2CIJU@1|root,332RU@2|Bacteria,1VESI@1239|Firmicutes,24QR7@186801|Clostridia,36MZM@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1893)	-	-	-	-	-	-	-	-	-	-	-	-	TM1506
SRR21617310_k127_1559848_2	985053.VMUT_1615	2.522e-13	73.0	COG4888@1|root,arCOG04136@2157|Archaea,2XRI7@28889|Crenarchaeota	28889|Crenarchaeota	J	Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
SRR21617310_k127_1559848_1	368408.Tpen_0633	1.27e-83	284.0	COG1646@1|root,arCOG01085@2157|Archaea,2XPUP@28889|Crenarchaeota	28889|Crenarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
SRR21617310_k127_1559848_0	589924.Ferp_1250	2e-323	1024.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
SRR21617310_k127_1559848_4	1121924.ATWH01000001_gene4266	0.0008714	46.0	COG0394@1|root,COG0640@1|root,COG0394@2|Bacteria,COG0640@2|Bacteria,2IB1N@201174|Actinobacteria,4FNYP@85023|Microbacteriaceae	201174|Actinobacteria	KT	Low molecular weight phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LMWPc
SRR21617310_k127_1559848_3	1121423.JONT01000014_gene1267	1.452e-08	64.0	COG0697@1|root,COG0697@2|Bacteria,1TRTP@1239|Firmicutes,25CFI@186801|Clostridia	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
SRR21617310_k127_1563483_2	1120973.AQXL01000088_gene3241	8.934e-39	166.0	COG5002@1|root,COG5002@2|Bacteria,1VUBP@1239|Firmicutes,4HUPW@91061|Bacilli	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K02491	ko02020,map02020	M00485	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4
SRR21617310_k127_1563483_4	485913.Krac_6636	2.944e-08	67.0	COG0642@1|root,COG2205@2|Bacteria	485913.Krac_6636|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1563483_0	1131266.ARWQ01000001_gene1220	1.012e-65	237.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
SRR21617310_k127_1563483_3	909943.HIMB100_00011670	1.921e-16	91.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,4BTE3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRR21617310_k127_1563483_1	698769.JFBD01000035_gene1445	3.183e-40	158.0	COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,4HAR9@91061|Bacilli,4C4PQ@84406|Virgibacillus	91061|Bacilli	Q	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
SRR21617310_k127_1577512_0	374847.Kcr_1138	3.921e-123	406.0	COG1042@1|root,arCOG01340@2157|Archaea	2157|Archaea	C	Acyl-CoA synthetase (NDP forming)	acdA	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
SRR21617310_k127_1583245_0	634498.mru_0618	6.736e-75	261.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,23NNA@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
SRR21617310_k127_1583245_2	192952.MM_1139	2.483e-26	120.0	COG0463@1|root,arCOG01385@2157|Archaea,2XZI8@28890|Euryarchaeota,2NBGC@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR21617310_k127_1583245_1	186497.PF2046	4.648e-31	132.0	arCOG05719@1|root,arCOG05719@2157|Archaea,2Y2UN@28890|Euryarchaeota,2434Z@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF4152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4152
SRR21617310_k127_1605319_1	903814.ELI_0666	1.523e-151	499.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,25V7G@186806|Eubacteriaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SRR21617310_k127_1605319_0	858215.Thexy_0923	7.541e-250	799.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SRR21617310_k127_1605319_5	1459636.NTE_00452	8.761e-91	310.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SRR21617310_k127_1605319_4	1459636.NTE_00046	1.432e-92	316.0	COG0226@1|root,arCOG08033@1|root,arCOG00213@2157|Archaea,arCOG08033@2157|Archaea,41SXU@651137|Thaumarchaeota	651137|Thaumarchaeota	P	TIGRFAM phosphate ABC transporter	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SRR21617310_k127_1605319_3	1459636.NTE_00045	1.09e-101	340.0	COG0573@1|root,arCOG00167@2157|Archaea,41SYE@651137|Thaumarchaeota	651137|Thaumarchaeota	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SRR21617310_k127_1605319_6	436308.Nmar_0482	1.355e-78	271.0	COG0581@1|root,arCOG00168@2157|Archaea,41SZ4@651137|Thaumarchaeota	651137|Thaumarchaeota	P	TIGRFAM phosphate ABC transporter	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SRR21617310_k127_1605319_2	1459636.NTE_00043	1.151e-105	349.0	COG1117@1|root,arCOG00231@2157|Archaea,41SYJ@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
SRR21617310_k127_1605319_7	436308.Nmar_0484	2.597e-39	154.0	COG0704@1|root,arCOG00232@2157|Archaea,41T42@651137|Thaumarchaeota	651137|Thaumarchaeota	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
SRR21617310_k127_1605319_9	1184251.TCELL_0961	4.444e-17	89.0	COG1392@1|root,arCOG02640@2157|Archaea,2XQJ3@28889|Crenarchaeota	28889|Crenarchaeota	P	phosphate transport	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SRR21617310_k127_1605319_8	436308.Nmar_0488	6.404e-35	139.0	COG0394@1|root,arCOG04425@2157|Archaea,41T49@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
SRR21617310_k127_1610912_2	386456.JQKN01000016_gene901	6.258e-22	108.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
SRR21617310_k127_1610912_1	439481.Aboo_0753	7.246e-31	139.0	COG1215@1|root,arCOG01391@2157|Archaea,2XYDG@28890|Euryarchaeota,3F2WW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_tranf_2_3,Glyco_trans_2_3
SRR21617310_k127_1610912_0	420247.Msm_1058	2.492e-36	154.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
SRR21617310_k127_1617842_6	665956.HMPREF1032_01125	9.741e-05	55.0	COG1305@1|root,COG1305@2|Bacteria,1TP7G@1239|Firmicutes,24BSB@186801|Clostridia,3WM58@541000|Ruminococcaceae	186801|Clostridia	E	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SRR21617310_k127_1617842_1	443144.GM21_2441	1.008e-29	130.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,42PJB@68525|delta/epsilon subdivisions,2WK1X@28221|Deltaproteobacteria,43VMU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
SRR21617310_k127_1617842_0	1191523.MROS_0400	6.717e-78	273.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
SRR21617310_k127_1617842_3	591019.Shell_1261	2.423e-14	84.0	arCOG07758@1|root,arCOG07758@2157|Archaea,2XSAT@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1617842_4	1459636.NTE_02332	1.957e-09	68.0	arCOG10526@1|root,arCOG10526@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1617842_2	374847.Kcr_0790	1.338e-24	112.0	arCOG09429@1|root,arCOG09429@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1617842_5	935863.AWZR01000003_gene2833	3.018e-05	54.0	COG2244@1|root,COG2244@2|Bacteria,1R9CF@1224|Proteobacteria,1T6QM@1236|Gammaproteobacteria,1X7XA@135614|Xanthomonadales	135614|Xanthomonadales	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
SRR21617310_k127_1653014_0	673860.AciM339_0086	4.195e-234	743.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,3F2Z5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
SRR21617310_k127_1653014_1	370438.PTH_1573	3.267e-33	133.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,260KZ@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRR21617310_k127_165708_0	593117.TGAM_1014	6.234e-80	274.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MB@28890|Euryarchaeota	28890|Euryarchaeota	E	PFAM ABC transporter	-	-	3.6.3.29,3.6.3.30	ko:K02010,ko:K02017,ko:K02062,ko:K10112,ko:K10199,ko:K17314	ko02010,map02010	M00189,M00190,M00191,M00194,M00196,M00197,M00200,M00201,M00203,M00206,M00207,M00491,M00602,M00604,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.13,3.A.1.1.14,3.A.1.1.15,3.A.1.10,3.A.1.19,3.A.1.8	-	-	ABC_tran,TOBE_2
SRR21617310_k127_165708_1	1231391.AMZF01000063_gene1102	2.112e-78	283.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VMRE@28216|Betaproteobacteria,3T2HR@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
SRR21617310_k127_165708_2	1278308.KB907075_gene1143	4.555e-16	89.0	COG1840@1|root,COG1840@2|Bacteria,2HSTD@201174|Actinobacteria,4FQD1@85023|Microbacteriaceae	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
SRR21617310_k127_1681980_0	595460.RRSWK_00138	1.667e-07	63.0	COG0389@1|root,COG0389@2|Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF4332,IMS,IMS_C,NACHT
SRR21617310_k127_1681980_1	648996.Theam_1507	8.486e-06	56.0	COG3743@1|root,COG3743@2|Bacteria,2G52I@200783|Aquificae	200783|Aquificae	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
SRR21617310_k127_1689531_1	1304284.L21TH_1399	1.057e-66	238.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRR21617310_k127_1689531_3	1459636.NTE_01688	1.073e-18	90.0	COG3269@1|root,arCOG01641@2157|Archaea	2157|Archaea	J	RNA-binding protein contains TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
SRR21617310_k127_1689531_4	273116.14325498	9.903e-18	86.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y7BB@28890|Euryarchaeota,242B4@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
SRR21617310_k127_1689531_2	192952.MM_1231	5.711e-54	194.0	arCOG02703@1|root,arCOG02703@2157|Archaea	2157|Archaea	S	Methyltransferase type 11	aknG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
SRR21617310_k127_1689531_5	311424.DhcVS_568	1.329e-07	66.0	2A4AU@1|root,30SWE@2|Bacteria,2GARB@200795|Chloroflexi,34D5K@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1689531_7	195522.BD01_1153	4.278e-05	58.0	arCOG03553@1|root,arCOG03610@1|root,arCOG03553@2157|Archaea,arCOG03610@2157|Archaea	2157|Archaea	O	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF3344,PKD
SRR21617310_k127_1689531_6	647113.Metok_0493	2.303e-07	65.0	COG1572@1|root,COG3291@1|root,arCOG03606@1|root,arCOG02510@2157|Archaea,arCOG02532@2157|Archaea,arCOG03396@2157|Archaea,arCOG03606@2157|Archaea	2157|Archaea	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	A2M_comp,CARDB,CarboxypepD_reg,Collagen,DUF3344,PKD,Prenyltrans,Thiol-ester_cl
SRR21617310_k127_1689531_0	1122947.FR7_0764	5.02e-74	256.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
SRR21617310_k127_1698121_1	1094980.Mpsy_1639	1.695e-61	215.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
SRR21617310_k127_1698121_6	224325.AF_0284	1.521e-20	101.0	COG1545@1|root,arCOG01283@2157|Archaea,2XX0U@28890|Euryarchaeota,24665@183980|Archaeoglobi	183980|Archaeoglobi	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SRR21617310_k127_1698121_7	755731.Clo1100_2498	2.233e-15	85.0	COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24CRF@186801|Clostridia,36I2K@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
SRR21617310_k127_1698121_5	196367.JNFG01000016_gene4073	1.869e-27	121.0	COG0491@1|root,COG0491@2|Bacteria,1NFZ3@1224|Proteobacteria,2WEMI@28216|Betaproteobacteria,1KHSD@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRR21617310_k127_1698121_2	1343739.PAP_10255	1.237e-56	206.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,242T2@183968|Thermococci	183968|Thermococci	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
SRR21617310_k127_1698121_8	311424.DhcVS_1445	1.376e-09	64.0	2A40N@1|root,30SJ6@2|Bacteria,2G9WM@200795|Chloroflexi,34DKR@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1698121_4	398512.JQKC01000044_gene1246	8.649e-32	132.0	28PJ3@1|root,2ZC8W@2|Bacteria,1V220@1239|Firmicutes,24IPD@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1698121_3	342949.PNA2_1582	3.865e-37	151.0	COG0500@1|root,arCOG01773@2157|Archaea,2Y7UH@28890|Euryarchaeota,245KZ@183968|Thermococci	183968|Thermococci	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR21617310_k127_1698121_0	391623.TERMP_01507	4.76e-64	231.0	COG1668@1|root,arCOG01462@2157|Archaea,2XXQM@28890|Euryarchaeota,245BX@183968|Thermococci	183968|Thermococci	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SRR21617310_k127_1700944_3	411467.BACCAP_03776	1.475e-32	130.0	COG1478@1|root,COG1478@2|Bacteria,1VJJZ@1239|Firmicutes,24UBN@186801|Clostridia	186801|Clostridia	S	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
SRR21617310_k127_1700944_2	374847.Kcr_0835	1.306e-55	205.0	COG1478@1|root,arCOG02714@2157|Archaea	2157|Archaea	E	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	GO:0003674,GO:0003824,GO:0016874,GO:0016879,GO:0016881,GO:0052618	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
SRR21617310_k127_1700944_0	399550.Smar_1256	5.336e-110	369.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
SRR21617310_k127_1700944_1	933801.Ahos_1388	1.674e-70	245.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
SRR21617310_k127_1702736_4	1151117.AJLF01000002_gene83	3.318e-61	215.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
SRR21617310_k127_1702736_0	391623.TERMP_00163	4.671e-95	318.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
SRR21617310_k127_1702736_3	415426.Hbut_0570	7.942e-62	222.0	COG1097@1|root,arCOG00678@2157|Archaea,2XQE2@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1,KH_6
SRR21617310_k127_1702736_1	1459636.NTE_01339	2.596e-77	265.0	COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
SRR21617310_k127_1702736_2	1459636.NTE_01839	3.471e-66	233.0	COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Proteasome endopeptidase complex	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
SRR21617310_k127_1702736_5	706434.HMPREF9429_00428	5.01e-39	162.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4H2H6@909932|Negativicutes	909932|Negativicutes	V	Efflux ABC transporter permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
SRR21617310_k127_1702736_6	926569.ANT_07660	1.754e-28	116.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR21617310_k127_1703312_1	1236689.MMALV_07510	6.124e-31	128.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,3F34R@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Archaeal Nre, N-terminal	nreA	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
SRR21617310_k127_1703312_0	1131462.DCF50_p2293	5.332e-54	204.0	COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia,25ZY3@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SRR21617310_k127_173535_1	457570.Nther_0771	1.275e-71	249.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
SRR21617310_k127_173535_3	1158318.ATXC01000001_gene824	1.587e-37	156.0	COG0420@1|root,COG0420@2|Bacteria,2G45D@200783|Aquificae	200783|Aquificae	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
SRR21617310_k127_173535_4	439481.Aboo_0855	5.917e-36	157.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,3F2VF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA domain	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
SRR21617310_k127_173535_5	399550.Smar_0038	9.033e-19	94.0	COG1392@1|root,arCOG02640@2157|Archaea,2XQJ3@28889|Crenarchaeota	28889|Crenarchaeota	P	phosphate transport	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
SRR21617310_k127_173535_0	1236689.MMALV_02220	2.229e-90	310.0	COG3839@1|root,arCOG00177@2157|Archaea,2XTU1@28890|Euryarchaeota,3F2MM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	ABC transporter	potA	-	3.6.3.29,3.6.3.30,3.6.3.31,3.6.3.55	ko:K02010,ko:K02017,ko:K02052,ko:K02062,ko:K10112,ko:K11072,ko:K15497,ko:K17240	ko02010,ko02024,map02010,map02024	M00189,M00190,M00191,M00193,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00299,M00423,M00491,M00599,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.38,3.A.1.10,3.A.1.11,3.A.1.11.1,3.A.1.19,3.A.1.6.5,3.A.1.8	-	-	ABC_tran,TOBE_2
SRR21617310_k127_173535_2	1236689.MMALV_02210	1.706e-61	227.0	COG1178@1|root,arCOG00163@2157|Archaea	2157|Archaea	P	ABC-type Fe3 transport system permease component	-	-	-	ko:K02053,ko:K02054,ko:K02063	ko02010,ko02024,map02010,map02024	M00191,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.19	-	-	BPD_transp_1
SRR21617310_k127_1736325_3	573064.Mefer_0073	5.802e-06	53.0	arCOG06562@1|root,arCOG06562@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1736325_2	456320.Mvol_1374	1.376e-17	93.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,23Q6K@183939|Methanococci	183939|Methanococci	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
SRR21617310_k127_1736325_0	693661.Arcve_0808	3.567e-27	123.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,245QK@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
SRR21617310_k127_1736325_1	1220534.B655_1746	5.629e-21	100.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
SRR21617310_k127_1760874_1	521011.Mpal_1981	2.811e-44	167.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,2N9X7@224756|Methanomicrobia	224756|Methanomicrobia	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
SRR21617310_k127_1760874_2	330779.Saci_1416	2.872e-36	145.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
SRR21617310_k127_1760874_3	1236542.BALM01000008_gene2955	1.611e-21	104.0	COG2227@1|root,COG2227@2|Bacteria,1MY0S@1224|Proteobacteria,1RP69@1236|Gammaproteobacteria,2QAUV@267890|Shewanellaceae	1236|Gammaproteobacteria	H	Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs	cmoM	GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097697,GO:0140098,GO:0140101,GO:1901360	-	ko:K06219	-	-	-	-	ko00000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
SRR21617310_k127_1760874_0	572546.Arcpr_1724	1.561e-68	243.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota,246Y8@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR21617310_k127_1788096_0	273075.Ta0351	5.587e-62	222.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRR21617310_k127_1788096_2	410359.Pcal_1310	8.883e-05	52.0	COG1545@1|root,arCOG01284@2157|Archaea	2157|Archaea	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SRR21617310_k127_1788096_1	439481.Aboo_0021	9.093e-13	75.0	COG1522@1|root,arCOG01580@2157|Archaea,2Y6YT@28890|Euryarchaeota,3F2Y0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1818042_1	868131.MSWAN_0783	2.2e-95	321.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SRR21617310_k127_1818042_2	909663.KI867150_gene662	1.905e-55	201.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42QX3@68525|delta/epsilon subdivisions,2WPC7@28221|Deltaproteobacteria,2MRS6@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	4Fe-4S single cluster domain	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SRR21617310_k127_1818042_4	368408.Tpen_0751	1.861e-16	87.0	arCOG05463@1|root,arCOG05463@2157|Archaea,2XSF3@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1818042_3	1459636.NTE_02378	4.898e-22	103.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
SRR21617310_k127_1818042_5	1185876.BN8_00940	3.516e-13	76.0	COG1522@1|root,COG1522@2|Bacteria,4NNH2@976|Bacteroidetes,47PFB@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix ASNC type	-	-	-	ko:K03719,ko:K05800	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
SRR21617310_k127_1818042_6	591019.Shell_1059	1.854e-08	61.0	COG1449@1|root,arCOG03278@2157|Archaea,2XQ1R@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
SRR21617310_k127_1818042_0	368408.Tpen_0750	6.732e-157	504.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
SRR21617310_k127_1827462_5	1040982.AXAL01000024_gene6302	8.764e-12	70.0	2E69N@1|root,330XJ@2|Bacteria,1NM8X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1827462_0	797299.HALLA_20500	1.466e-220	717.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,23S50@183963|Halobacteria	183963|Halobacteria	K	DEAD H associated	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SRR21617310_k127_1827462_4	204536.SULAZ_0053	3.174e-12	77.0	COG0449@1|root,COG0449@2|Bacteria,2G3KT@200783|Aquificae	200783|Aquificae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SRR21617310_k127_1827462_2	930945.SiRe_1200	5.748e-42	163.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
SRR21617310_k127_1827462_6	933801.Ahos_1333	4.18e-11	74.0	arCOG04054@1|root,arCOG04054@2157|Archaea,2XPUY@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRC
SRR21617310_k127_1827462_3	1006006.Mcup_0109	2.795e-17	93.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1827462_1	1459636.NTE_03020	5.785e-138	451.0	COG0464@1|root,arCOG01307@2157|Archaea,41SA4@651137|Thaumarchaeota	651137|Thaumarchaeota	D	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,MIT,Vps4_C
SRR21617310_k127_1827462_7	387631.Asulf_02272	7.723e-05	49.0	arCOG04467@1|root,arCOG04467@2157|Archaea,2Y56M@28890|Euryarchaeota,247FT@183980|Archaeoglobi	183980|Archaeoglobi	H	Mo-molybdopterin cofactor metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1829211_4	671065.MetMK1DRAFT_00031890	2.074e-05	52.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SRR21617310_k127_1829211_0	1382359.JIAL01000001_gene1979	4.918e-116	387.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
SRR21617310_k127_1829211_3	1216932.CM240_1184	9.9e-12	72.0	COG1522@1|root,COG1522@2|Bacteria,1V2UC@1239|Firmicutes,25DYA@186801|Clostridia,36I9Q@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, AsnC family	asnC	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SRR21617310_k127_1829211_2	529709.PYCH_04890	1.038e-13	77.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX3W@28890|Euryarchaeota,2442A@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator	lrpA	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SRR21617310_k127_1829211_1	1459636.NTE_00183	1.11e-44	170.0	COG0477@1|root,arCOG00130@2157|Archaea,arCOG00134@2157|Archaea	2157|Archaea	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
SRR21617310_k127_1860787_3	667014.Thein_1407	9.228e-09	66.0	COG0454@1|root,COG0456@2|Bacteria,2GHSZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
SRR21617310_k127_1860787_1	1151117.AJLF01000001_gene1724	2.114e-65	237.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
SRR21617310_k127_1860787_0	415426.Hbut_0892	3.617e-66	233.0	COG2413@1|root,arCOG04066@2157|Archaea,2XQ4I@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
SRR21617310_k127_1860787_2	1042877.GQS_06845	5.376e-38	154.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,243C5@183968|Thermococci	183968|Thermococci	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
SRR21617310_k127_1865503_1	243274.THEMA_07380	6.747e-10	63.0	COG0500@1|root,COG2226@2|Bacteria,2GD3D@200918|Thermotogae	200918|Thermotogae	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SRR21617310_k127_1865503_0	694429.Pyrfu_0109	2.505e-125	409.0	COG0258@1|root,arCOG04050@2157|Archaea,2XPRH@28889|Crenarchaeota	28889|Crenarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
SRR21617310_k127_1877017_1	1379698.RBG1_1C00001G0738	1.395e-20	95.0	COG2146@1|root,COG2146@2|Bacteria,2NQ87@2323|unclassified Bacteria	2|Bacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	FeS_assembly_P,Rieske
SRR21617310_k127_1877017_2	386456.JQKN01000001_gene1962	1.577e-15	83.0	COG4010@1|root,arCOG04906@2157|Archaea,2XZ3A@28890|Euryarchaeota,23P5J@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized protein conserved in archaea (DUF2096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2096
SRR21617310_k127_1877017_0	69014.TK1017	5.028e-82	304.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
SRR21617310_k127_1886522_1	985053.VMUT_1234	8.055e-49	179.0	COG0674@1|root,arCOG01606@2157|Archaea	2157|Archaea	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	korA	-	1.2.7.1,1.2.7.11,1.2.7.3	ko:K00169,ko:K00174	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00307,M00374,M00620	R01196,R01197,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
SRR21617310_k127_1886522_0	1459636.NTE_01234	8.365e-149	477.0	COG1013@1|root,arCOG01599@2157|Archaea,41SAB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
SRR21617310_k127_1886522_2	1183438.GKIL_2755	1.754e-28	120.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
SRR21617310_k127_1888340_2	1211777.BN77_0993	0.0007856	46.0	COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TUMB@28211|Alphaproteobacteria,4B8AF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
SRR21617310_k127_1888340_1	374847.Kcr_0665	3.09e-116	385.0	COG0498@1|root,arCOG01434@2157|Archaea	2157|Archaea	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC4	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRR21617310_k127_1888340_0	374847.Kcr_1093	1.474e-124	426.0	COG0747@1|root,arCOG01534@2157|Archaea	2157|Archaea	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRR21617310_k127_1895750_0	1121430.JMLG01000004_gene880	1.336e-118	387.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24DPN@186801|Clostridia	186801|Clostridia	I	TIGRFAM Acetoacetyl-CoA synthase	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
SRR21617310_k127_1895750_3	309801.trd_0440	1.237e-08	66.0	COG2006@1|root,COG2006@2|Bacteria,2GA2Y@200795|Chloroflexi,27YWH@189775|Thermomicrobia	189775|Thermomicrobia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SRR21617310_k127_1895750_1	1232410.KI421419_gene2452	1.02e-52	198.0	COG1893@1|root,COG1893@2|Bacteria,1R96Z@1224|Proteobacteria,42PU0@68525|delta/epsilon subdivisions,2WK47@28221|Deltaproteobacteria,43SYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
SRR21617310_k127_1895750_2	439235.Dalk_3846	2.119e-43	168.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria	1224|Proteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SRR21617310_k127_1898259_2	1121423.JONT01000012_gene395	2.203e-08	57.0	COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,249J5@186801|Clostridia	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxD,DoxX,Pyr_redox_2
SRR21617310_k127_1898259_1	330779.Saci_0799	2.171e-11	68.0	COG1958@1|root,arCOG00998@2157|Archaea,2XR32@28889|Crenarchaeota	28889|Crenarchaeota	K	SMART Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
SRR21617310_k127_1898259_3	694429.Pyrfu_1029	6.089e-06	53.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K11924	-	-	-	-	ko00000,ko03000	-	-	-	HTH_45
SRR21617310_k127_1898259_0	32057.KB217478_gene3555	1.51e-26	111.0	2DNQD@1|root,32YJR@2|Bacteria,1GB5G@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF3303)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3303
SRR21617310_k127_1907555_1	246194.CHY_2336	2.142e-14	74.0	COG1351@1|root,COG1351@2|Bacteria,1TRAA@1239|Firmicutes,249DJ@186801|Clostridia,42G34@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
SRR21617310_k127_1907555_0	391623.TERMP_00308	1.325e-72	257.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,24390@183968|Thermococci	183968|Thermococci	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
SRR21617310_k127_1907555_2	457429.ABJI02000398_gene6667	4.955e-08	64.0	COG1277@1|root,COG1277@2|Bacteria,2GK3E@201174|Actinobacteria	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
SRR21617310_k127_1907555_3	1410626.JHXB01000014_gene882	6.308e-06	52.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,27I8G@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR21617310_k127_192130_1	2340.JV46_19510	8.892e-21	102.0	COG0436@1|root,COG0436@2|Bacteria,1MX43@1224|Proteobacteria,1RZ0G@1236|Gammaproteobacteria,1JAJY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SRR21617310_k127_192130_2	1121430.JMLG01000008_gene1538	1.154e-10	64.0	COG1149@1|root,COG1149@2|Bacteria,1VUEG@1239|Firmicutes,2503A@186801|Clostridia,267CF@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_21,Fer4_6
SRR21617310_k127_192130_0	868131.MSWAN_0320	2.906e-126	417.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,23NWK@183925|Methanobacteria	183925|Methanobacteria	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
SRR21617310_k127_1924056_2	269797.Mbar_A3206	1.439e-81	286.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
SRR21617310_k127_1924056_0	573063.Metin_0975	1.289e-137	451.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,23QJI@183939|Methanococci	183939|Methanococci	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
SRR21617310_k127_1924056_6	386456.JQKN01000019_gene1279	5.077e-25	110.0	COG0195@1|root,arCOG01761@2157|Archaea,2XWJU@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	KH_5
SRR21617310_k127_1924056_4	593117.TGAM_1552	1.051e-26	111.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
SRR21617310_k127_1924056_3	593117.TGAM_1766	1.146e-38	149.0	COG1522@1|root,arCOG01118@2157|Archaea,2XWRI@28890|Euryarchaeota,24403@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_Crp_2,MarR_2
SRR21617310_k127_1924056_1	633148.Tagg_1018	7.746e-107	359.0	COG0045@1|root,arCOG01337@2157|Archaea,2XPUW@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
SRR21617310_k127_1924056_5	698757.Pogu_0684	1.524e-26	110.0	COG0074@1|root,arCOG01339@2157|Archaea,2XPW3@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
SRR21617310_k127_1959350_3	1214065.BAGV01000032_gene728	0.0001616	46.0	COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,1RMZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	fosmidomycin resistance protein	fsr	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
SRR21617310_k127_1959350_2	948106.AWZT01000026_gene2389	8.771e-05	51.0	COG1522@1|root,COG1522@2|Bacteria,1RJ60@1224|Proteobacteria,2VRDZ@28216|Betaproteobacteria,1K70B@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
SRR21617310_k127_1959350_1	1459636.NTE_02412	1.168e-05	51.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_1959350_0	909663.KI867150_gene2080	1.839e-10	71.0	COG2014@1|root,COG2014@2|Bacteria,1RCPD@1224|Proteobacteria,42R4E@68525|delta/epsilon subdivisions,2WN0E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative heavy-metal chelation	-	-	-	-	-	-	-	-	-	-	-	-	DUF364,DUF4213
SRR21617310_k127_1977674_5	374847.Kcr_0332	9.955e-25	116.0	arCOG03462@1|root,arCOG03462@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
SRR21617310_k127_1977674_3	1041930.Mtc_1365	1.883e-72	256.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2N91B@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-2	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
SRR21617310_k127_1977674_7	555779.Dthio_PD3428	3.542e-07	61.0	2CX8V@1|root,32T1H@2|Bacteria,1P0EI@1224|Proteobacteria,431BK@68525|delta/epsilon subdivisions,2WWP7@28221|Deltaproteobacteria,2MFZ9@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_1977674_6	1118054.CAGW01000081_gene2621	4.177e-21	106.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HEZ6@91061|Bacilli	91061|Bacilli	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
SRR21617310_k127_1977674_0	374847.Kcr_0329	3.934e-187	595.0	COG0001@1|root,arCOG00918@2157|Archaea	2157|Archaea	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SRR21617310_k127_1977674_1	696369.KI912183_gene2506	3.509e-167	546.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260VN@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SRR21617310_k127_1977674_2	555779.Dthio_PD0371	3.071e-162	525.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria,2M8B8@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
SRR21617310_k127_1977674_8	177437.HRM2_41020	0.0001112	53.0	COG1633@1|root,COG1633@2|Bacteria,1N4PW@1224|Proteobacteria,42UZG@68525|delta/epsilon subdivisions,2WNGQ@28221|Deltaproteobacteria,2MJYE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
SRR21617310_k127_1977674_4	589924.Ferp_1675	2.444e-39	151.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,245TB@183980|Archaeoglobi	183980|Archaeoglobi	I	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SRR21617310_k127_2019762_3	1343739.PAP_10150	6.796e-06	55.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX9F@28890|Euryarchaeota,243Z9@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
SRR21617310_k127_2019762_2	1131266.ARWQ01000006_gene246	2.323e-15	88.0	arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
SRR21617310_k127_2019762_0	243232.MJ_1000	4.326e-81	292.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,23Q2X@183939|Methanococci	183939|Methanococci	J	PFAM tRNA synthetase, class II (G, H, P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
SRR21617310_k127_2019762_1	1459636.NTE_01681	1.206e-33	137.0	COG1676@1|root,arCOG01701@2157|Archaea,41SJY@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
SRR21617310_k127_2037014_1	909663.KI867150_gene622	4.33e-71	245.0	COG1584@1|root,COG1584@2|Bacteria,1N3HP@1224|Proteobacteria,42QSA@68525|delta/epsilon subdivisions,2WN08@28221|Deltaproteobacteria,2MRW3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	GPR1/FUN34/yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
SRR21617310_k127_2037014_0	665956.HMPREF1032_02369	1.836e-252	797.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3WHVU@541000|Ruminococcaceae	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
SRR21617310_k127_2037014_2	338966.Ppro_3526	5.392e-15	77.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WNT3@28221|Deltaproteobacteria,43UYP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	-	ko:K14088	-	-	-	-	ko00000	-	-	-	Oxidored_q6
SRR21617310_k127_2052663_5	436308.Nmar_1717	1.916e-41	160.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
SRR21617310_k127_2052663_2	436308.Nmar_0002	2.9e-101	350.0	COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
SRR21617310_k127_2052663_0	246969.TAM4_1154	7.59e-130	426.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
SRR21617310_k127_2052663_7	1094980.Mpsy_2445	1.945e-06	55.0	arCOG04038@1|root,arCOG04038@2157|Archaea,2Y5TS@28890|Euryarchaeota,2NBDA@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2052663_6	580327.Tthe_1387	6.706e-14	85.0	COG0433@1|root,COG0433@2|Bacteria,1UD3Y@1239|Firmicutes,24DTE@186801|Clostridia	186801|Clostridia	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
SRR21617310_k127_2052663_8	1229909.NSED_09625	0.0008778	50.0	arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
SRR21617310_k127_2052663_1	391623.TERMP_00724	7.499e-111	371.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,242SN@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
SRR21617310_k127_2052663_3	1234664.AMRO01000002_gene2196	4.697e-65	234.0	COG0388@1|root,COG0388@2|Bacteria,1UX58@1239|Firmicutes,4IE20@91061|Bacilli,1WHNS@129337|Geobacillus	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
SRR21617310_k127_2052663_4	985053.VMUT_0432	7.206e-64	228.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
SRR21617310_k127_2062195_2	443254.Marpi_1490	2.059e-19	101.0	COG1449@1|root,COG4945@1|root,COG1449@2|Bacteria,COG4945@2|Bacteria,2GC51@200918|Thermotogae	200918|Thermotogae	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Glucodextran_C,Glyco_hydro_57
SRR21617310_k127_2062195_0	342949.PNA2_0258	2.168e-91	309.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
SRR21617310_k127_2062195_5	323259.Mhun_3021	1.101e-05	53.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y1IQ@28890|Euryarchaeota,2NA28@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
SRR21617310_k127_2062195_4	391623.TERMP_01089	1.927e-14	77.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y0R1@28890|Euryarchaeota,244JC@183968|Thermococci	183968|Thermococci	J	rRNA binding	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
SRR21617310_k127_2062195_1	386456.JQKN01000002_gene2860	6.085e-50	185.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,23NZP@183925|Methanobacteria	183925|Methanobacteria	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
SRR21617310_k127_2062195_3	243232.MJ_0049	2.993e-16	83.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,23R3K@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein L31e	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
SRR21617310_k127_2065291_1	1232410.KI421415_gene2936	1.126e-15	86.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
SRR21617310_k127_2065291_0	1094980.Mpsy_1395	1.072e-26	119.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,2N9XX@224756|Methanomicrobia	224756|Methanomicrobia	N	Peptidase A24A, prepilin type IV	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
SRR21617310_k127_2065291_2	368408.Tpen_1214	3.844e-06	56.0	arCOG03871@1|root,arCOG03871@2157|Archaea,2XRGZ@28889|Crenarchaeota	28889|Crenarchaeota	N	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2067028_4	70601.3257896	1.052e-64	227.0	COG1573@1|root,arCOG00905@2157|Archaea,2XUVI@28890|Euryarchaeota,243FM@183968|Thermococci	183968|Thermococci	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
SRR21617310_k127_2067028_6	1379698.RBG1_1C00001G1028	1.423e-40	156.0	COG2094@1|root,COG2094@2|Bacteria,2NPMI@2323|unclassified Bacteria	2|Bacteria	L	Belongs to the DNA glycosylase MPG family	mpg	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
SRR21617310_k127_2067028_1	562970.Btus_0575	8.038e-116	389.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,27802@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
SRR21617310_k127_2067028_5	666510.ASAC_0939	2.703e-45	171.0	COG2110@1|root,arCOG04225@2157|Archaea,2XQEQ@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Appr-1-p processing domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
SRR21617310_k127_2067028_7	593117.TGAM_0585	1.162e-34	143.0	COG1402@1|root,arCOG04536@2157|Archaea,2XTQE@28890|Euryarchaeota,243GI@183968|Thermococci	183968|Thermococci	H	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
SRR21617310_k127_2067028_0	1041930.Mtc_0381	2.637e-138	454.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
SRR21617310_k127_2067028_8	591019.Shell_1026	2.043e-27	126.0	COG1305@1|root,arCOG02165@2157|Archaea,2XRIK@28889|Crenarchaeota	28889|Crenarchaeota	E	transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
SRR21617310_k127_2067028_3	374847.Kcr_1490	1.397e-69	243.0	COG0090@1|root,arCOG04067@2157|Archaea	2157|Archaea	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
SRR21617310_k127_2067028_9	1280689.AUJC01000003_gene886	2.766e-13	79.0	COG1378@1|root,COG1378@2|Bacteria,1UV3K@1239|Firmicutes,25CS7@186801|Clostridia,36X00@31979|Clostridiaceae	186801|Clostridia	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
SRR21617310_k127_2067028_10	768710.DesyoDRAFT_1514	2.124e-09	62.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
SRR21617310_k127_2067028_2	335543.Sfum_0266	8.03e-100	332.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MRCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,Methyltransf_31
SRR21617310_k127_209354_3	304371.MCP_0715	5.476e-49	183.0	COG2006@1|root,arCOG02447@2157|Archaea,2XWUP@28890|Euryarchaeota,2NB6D@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SRR21617310_k127_209354_4	573064.Mefer_0030	6.034e-23	111.0	COG1819@1|root,arCOG01393@2157|Archaea,2XVXT@28890|Euryarchaeota,23QI7@183939|Methanococci	183939|Methanococci	G	PFAM Glycosyltransferase 28 domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_trans_1_3
SRR21617310_k127_209354_2	1385935.N836_08400	1.165e-58	207.0	COG1225@1|root,COG1225@2|Bacteria,1G59X@1117|Cyanobacteria,1HAY7@1150|Oscillatoriales	1117|Cyanobacteria	O	Alkyl hydroperoxide reductase	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
SRR21617310_k127_209354_0	1459636.NTE_02750	0.0	1330.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
SRR21617310_k127_209354_1	415426.Hbut_1574	1.155e-256	811.0	COG0086@1|root,arCOG04257@2157|Archaea,2XPT5@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
SRR21617310_k127_2095430_2	374847.Kcr_0146	2.985e-32	132.0	COG1007@1|root,arCOG01540@2157|Archaea	2157|Archaea	C	NADH ubiquinone oxidoreductase subunit 2 (Chain N)	nuoN	-	1.1.98.4,1.6.5.3	ko:K00343,ko:K22181	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
SRR21617310_k127_2095430_0	192952.MM_0718	5.739e-60	222.0	COG0644@1|root,arCOG00570@2157|Archaea,2XWXQ@28890|Euryarchaeota,2N9RD@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
SRR21617310_k127_2095430_1	1121422.AUMW01000006_gene716	2.254e-40	153.0	COG2048@1|root,COG2048@2|Bacteria,1U4JW@1239|Firmicutes,24C8P@186801|Clostridia,260T4@186807|Peptococcaceae	186801|Clostridia	C	heterodisulfide reductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SRR21617310_k127_209647_0	706587.Desti_1479	5.183e-177	561.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,42N5K@68525|delta/epsilon subdivisions,2WK1G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase isomerase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
SRR21617310_k127_2098649_0	589924.Ferp_0652	9.473e-82	285.0	COG0123@1|root,arCOG00324@2157|Archaea,2XT0B@28890|Euryarchaeota,246V5@183980|Archaeoglobi	183980|Archaeoglobi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SRR21617310_k127_2098649_2	572546.Arcpr_0142	1.855e-13	72.0	COG1146@1|root,arCOG02618@2157|Archaea,2Y7JY@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
SRR21617310_k127_2098649_1	246969.TAM4_2161	3.246e-17	85.0	COG4003@1|root,arCOG05763@2157|Archaea,2Y3NV@28890|Euryarchaeota,2446V@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2095)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2095
SRR21617310_k127_2098649_3	243090.RB12718	6.159e-13	76.0	COG1418@1|root,COG1418@2|Bacteria,2IXYI@203682|Planctomycetes	203682|Planctomycetes	S	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
SRR21617310_k127_2101106_4	186497.PF1920	6.34e-59	209.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
SRR21617310_k127_2101106_5	374847.Kcr_0368	2.174e-52	197.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SRR21617310_k127_2101106_3	410359.Pcal_2009	4.024e-78	273.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
SRR21617310_k127_2101106_6	1220534.B655_1443	4.318e-48	183.0	COG0496@1|root,arCOG02303@2157|Archaea,2XT5R@28890|Euryarchaeota,23NXQ@183925|Methanobacteria	183925|Methanobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
SRR21617310_k127_2101106_7	370438.PTH_1653	5.094e-30	122.0	COG1254@1|root,COG1254@2|Bacteria,1VC7N@1239|Firmicutes,259HS@186801|Clostridia,2633Z@186807|Peptococcaceae	186801|Clostridia	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
SRR21617310_k127_2101106_0	604354.TSIB_0534	1.842e-183	590.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
SRR21617310_k127_2101106_2	5911.EAR95693	4.313e-85	294.0	COG0142@1|root,KOG0777@2759|Eukaryota,3ZB50@5878|Ciliophora	5878|Ciliophora	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00804	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00367	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
SRR21617310_k127_2101106_1	1041930.Mtc_2285	9.52e-107	357.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,2N94G@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
SRR21617310_k127_2101106_8	1220534.B655_1466	7.014e-07	52.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
SRR21617310_k127_2101414_0	671143.DAMO_0464	9.589e-256	809.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
SRR21617310_k127_2101414_1	203119.Cthe_1079	1.305e-108	359.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,3WGIE@541000|Ruminococcaceae	186801|Clostridia	GJM	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I
SRR21617310_k127_2101576_0	1056495.Calag_1421	1.797e-124	412.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
SRR21617310_k127_2101576_5	985053.VMUT_1349	5.204e-15	89.0	COG0747@1|root,arCOG01534@2157|Archaea	2157|Archaea	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRR21617310_k127_2101576_2	374847.Kcr_0930	1.549e-76	268.0	COG0601@1|root,arCOG00751@2157|Archaea	2157|Archaea	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SRR21617310_k127_2101576_3	304371.MCP_1562	1.558e-66	238.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota,2N9GM@224756|Methanomicrobia	224756|Methanomicrobia	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SRR21617310_k127_2101576_1	70601.3257835	7.738e-90	309.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,242V4@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SRR21617310_k127_2101576_4	439235.Dalk_0966	2.011e-19	89.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,42TDH@68525|delta/epsilon subdivisions,2WIQT@28221|Deltaproteobacteria,2MI06@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
SRR21617310_k127_2105445_1	1104325.M7W_2272	2.014e-15	77.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HCVN@91061|Bacilli,4B0MZ@81852|Enterococcaceae	91061|Bacilli	V	ABC transporter transmembrane region	XK27_10035	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SRR21617310_k127_2105445_0	485913.Krac_2495	1.128e-125	424.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi	200795|Chloroflexi	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
SRR21617310_k127_2108889_2	1183377.Py04_0032	5.958e-17	85.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
SRR21617310_k127_2108889_0	479434.Sthe_3442	4.993e-121	398.0	COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi,27XSM@189775|Thermomicrobia	2|Bacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
SRR21617310_k127_2108889_1	521045.Kole_1109	1.858e-21	103.0	COG1215@1|root,COG1215@2|Bacteria,2GDAY@200918|Thermotogae	200918|Thermotogae	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR21617310_k127_2108889_3	1054860.KB913030_gene1794	5.504e-06	54.0	COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SRR21617310_k127_211360_4	1122603.ATVI01000006_gene537	1.116e-06	53.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1X7MS@135614|Xanthomonadales	135614|Xanthomonadales	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
SRR21617310_k127_211360_2	96561.Dole_2664	7.163e-21	98.0	COG1661@1|root,COG1661@2|Bacteria,1NAWT@1224|Proteobacteria,42WJ4@68525|delta/epsilon subdivisions,2WRU1@28221|Deltaproteobacteria,2MNM8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
SRR21617310_k127_211360_0	374847.Kcr_1213	8.475e-69	241.0	COG0110@1|root,arCOG01848@2157|Archaea	2157|Archaea	E	COG0110 Acetyltransferase (isoleucine patch superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
SRR21617310_k127_211360_3	69014.TK1488	1.203e-09	66.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y1J3@28890|Euryarchaeota,243TB@183968|Thermococci	183968|Thermococci	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SRR21617310_k127_211360_1	1365176.N186_03495	2.089e-29	124.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
SRR21617310_k127_211360_5	572478.Vdis_2267	2.072e-05	49.0	arCOG05509@1|root,arCOG05509@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1922
SRR21617310_k127_211360_6	439481.Aboo_1479	0.0008363	50.0	arCOG13565@1|root,arCOG13565@2157|Archaea,2Y66R@28890|Euryarchaeota,3F331@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2124687_2	304371.MCP_1403	1.783e-15	81.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
SRR21617310_k127_2124687_1	243275.TDE_0826	3.396e-18	85.0	COG3422@1|root,COG3422@2|Bacteria,2J9C1@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF1508)	-	-	-	ko:K09946	-	-	-	-	ko00000	-	-	-	DUF1508
SRR21617310_k127_2124687_0	1211814.CAPG01000071_gene3336	2.404e-46	176.0	COG1834@1|root,COG1834@2|Bacteria,1TRPV@1239|Firmicutes,4H9YU@91061|Bacilli	91061|Bacilli	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
SRR21617310_k127_2124687_3	70601.3256446	1.115e-06	56.0	COG1522@1|root,arCOG01581@2157|Archaea,2Y3C6@28890|Euryarchaeota,2442S@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SRR21617310_k127_2133066_0	945713.IALB_2163	9.633e-31	141.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
SRR21617310_k127_2133066_2	644282.Deba_1334	5.852e-16	93.0	COG4412@1|root,COG4412@2|Bacteria,1RKAD@1224|Proteobacteria,43ARU@68525|delta/epsilon subdivisions,2X65X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Immune inhibitor A peptidase M6	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M6
SRR21617310_k127_2133066_3	399549.Msed_2295	2.635e-08	58.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
SRR21617310_k127_2133066_1	456442.Mboo_1556	1.238e-23	105.0	COG0328@1|root,arCOG02942@2157|Archaea,2XT22@28890|Euryarchaeota	28890|Euryarchaeota	L	COG0328 Ribonuclease HI	rnhA2	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
SRR21617310_k127_2147258_2	891968.Anamo_1259	3.631e-32	131.0	COG0508@1|root,COG0508@2|Bacteria,3TA12@508458|Synergistetes	508458|Synergistetes	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
SRR21617310_k127_2147258_1	552811.Dehly_1485	2.84e-109	370.0	COG0174@1|root,COG0174@2|Bacteria,2G61M@200795|Chloroflexi,34CIU@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
SRR21617310_k127_2147258_0	891968.Anamo_1263	1.223e-124	407.0	COG0022@1|root,COG0022@2|Bacteria,3TA38@508458|Synergistetes	508458|Synergistetes	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
SRR21617310_k127_215577_1	391623.TERMP_00159	1.309e-12	72.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2445Q@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
SRR21617310_k127_215577_0	1220534.B655_2423	4.475e-44	172.0	COG0053@1|root,arCOG01475@2157|Archaea,2Y8CZ@28890|Euryarchaeota	28890|Euryarchaeota	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,Nitro_FeMo-Co,ZT_dimer
SRR21617310_k127_215577_2	391623.TERMP_01378	5.003e-07	58.0	COG1522@1|root,arCOG01585@2157|Archaea,2XW1H@28890|Euryarchaeota,242Y6@183968|Thermococci	183968|Thermococci	K	Archaeal TRASH domain	-	-	-	-	-	-	-	-	-	-	-	-	Arc_trans_TRASH,HTH_24
SRR21617310_k127_2158947_2	933801.Ahos_1920	0.000228	52.0	COG0640@1|root,arCOG03859@2157|Archaea,2XR12@28889|Crenarchaeota	28889|Crenarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
SRR21617310_k127_2158947_1	985053.VMUT_1835	3.92e-12	75.0	arCOG06011@1|root,arCOG06011@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
SRR21617310_k127_2158947_0	694429.Pyrfu_0857	2.008e-16	85.0	arCOG04264@1|root,arCOG04264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2183095_1	521011.Mpal_1407	5.29e-65	228.0	COG0596@1|root,arCOG01648@2157|Archaea,2XW5K@28890|Euryarchaeota	28890|Euryarchaeota	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
SRR21617310_k127_2183095_2	365044.Pnap_4519	1.501e-23	111.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2VJJ4@28216|Betaproteobacteria,4ACHF@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
SRR21617310_k127_2183095_0	374847.Kcr_1036	9.206e-105	353.0	COG1960@1|root,arCOG04310@2157|Archaea	2157|Archaea	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRR21617310_k127_2183095_3	66373.JOFQ01000007_gene3325	6.403e-21	96.0	COG0044@1|root,COG0044@2|Bacteria,2IARA@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
SRR21617310_k127_219664_2	1123288.SOV_7c00310	1.328e-50	189.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,4H3AP@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
SRR21617310_k127_219664_3	589924.Ferp_1231	3.426e-47	175.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota,2477Y@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
SRR21617310_k127_219664_0	1125863.JAFN01000001_gene2649	1.779e-243	767.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SRR21617310_k127_219664_6	693661.Arcve_1915	1.26e-06	54.0	COG1977@1|root,arCOG00536@2157|Archaea,2Y64X@28890|Euryarchaeota,247EV@183980|Archaeoglobi	183980|Archaeoglobi	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SRR21617310_k127_219664_4	273116.14325212	7.688e-21	104.0	COG0704@1|root,arCOG00320@2157|Archaea	2157|Archaea	P	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SRR21617310_k127_219664_1	909663.KI867150_gene857	9.718e-154	493.0	COG1063@1|root,COG1063@2|Bacteria,1QVAK@1224|Proteobacteria,43BPR@68525|delta/epsilon subdivisions,2X70Z@28221|Deltaproteobacteria,2MR6P@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.368	ko:K07538	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05581	RC00850	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
SRR21617310_k127_2201213_1	1121405.dsmv_1485	2.973e-75	269.0	arCOG05143@1|root,2Z8AM@2|Bacteria,1NZHI@1224|Proteobacteria,430YM@68525|delta/epsilon subdivisions,2WVZ9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Monomethylamine methyltransferase MtmB	-	-	2.1.1.248	ko:K16176	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09998,R10014	RC00035,RC01144,RC02985	ko00000,ko00001,ko00002,ko01000	-	-	-	MtmB
SRR21617310_k127_2201213_2	1408428.JNJP01000041_gene2767	1.631e-56	204.0	COG5012@1|root,COG5012@2|Bacteria,1RDEU@1224|Proteobacteria,43BR3@68525|delta/epsilon subdivisions,2X7YW@28221|Deltaproteobacteria,2MHEU@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
SRR21617310_k127_2201213_0	1444309.JAQG01000005_gene4327	2.624e-79	278.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HA8B@91061|Bacilli,26USF@186822|Paenibacillaceae	91061|Bacilli	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
SRR21617310_k127_2201213_3	693661.Arcve_1118	1.18e-38	156.0	COG1145@1|root,arCOG02180@2157|Archaea,2XVTX@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4
SRR21617310_k127_2211411_3	1459636.NTE_03063	8.135e-10	66.0	COG0596@1|root,arCOG01648@2157|Archaea	2157|Archaea	IQ	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
SRR21617310_k127_2211411_2	456442.Mboo_0277	2.993e-24	107.0	COG1476@1|root,arCOG01864@2157|Archaea,2Y089@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
SRR21617310_k127_2211411_1	304371.MCP_2864	2.344e-64	238.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SRR21617310_k127_2211411_0	1041930.Mtc_1925	3.698e-85	288.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SRR21617310_k127_221315_0	648996.Theam_1273	2.397e-102	341.0	COG1053@1|root,COG1053@2|Bacteria,2G3PJ@200783|Aquificae	200783|Aquificae	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	sdhA	-	1.3.1.6,1.3.5.1,1.3.5.4	ko:K00239,ko:K18556	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R00402,R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SRR21617310_k127_221315_1	330214.NIDE2517	3.263e-72	255.0	COG0479@1|root,COG0479@2|Bacteria,3J14K@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10
SRR21617310_k127_221315_2	330214.NIDE2527	3.111e-22	101.0	COG2048@1|root,COG2048@2|Bacteria,3J175@40117|Nitrospirae	40117|Nitrospirae	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00241,ko:K03389	ko00020,ko00190,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00356,M00357,M00374,M00376,M00563,M00567	R02164,R04540,R11928,R11931,R11943,R11944	RC00011,RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SRR21617310_k127_2256556_1	523845.AQXV01000049_gene929	1.332e-58	207.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
SRR21617310_k127_2256556_0	386456.JQKN01000012_gene1040	1.675e-208	672.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,23NPD@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
SRR21617310_k127_2259521_2	1220534.B655_1297	1.22e-11	66.0	arCOG12322@1|root,arCOG12322@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2259521_0	153721.MYP_3119	4.201e-48	178.0	COG0262@1|root,COG0262@2|Bacteria,4NPX6@976|Bacteroidetes,47RPC@768503|Cytophagia	976|Bacteroidetes	H	RibD C-terminal domain	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
SRR21617310_k127_2259521_1	391623.TERMP_00743	5.512e-38	153.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,242NX@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SRR21617310_k127_226963_1	1408303.JNJJ01000046_gene980	5.688e-50	183.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4IMZ2@91061|Bacilli,1ZM9X@1386|Bacillus	91061|Bacilli	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SRR21617310_k127_226963_0	1183377.Py04_1357	1.354e-70	250.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,243JH@183968|Thermococci	183968|Thermococci	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SRR21617310_k127_226963_4	1183377.Py04_0134	8.576e-05	51.0	COG1522@1|root,arCOG01581@2157|Archaea,2Y3C6@28890|Euryarchaeota,2442S@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SRR21617310_k127_226963_3	1198449.ACAM_0140	1.145e-05	50.0	arCOG04057@1|root,arCOG04057@2157|Archaea,2XSD3@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL38 family	-	-	-	ko:K02923	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L38e
SRR21617310_k127_226963_2	243232.MJ_0281	7.978e-33	130.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota	28890|Euryarchaeota	S	zinc metalloprotease whose natural substrate is	amzA	GO:0003674,GO:0003824,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0071704,GO:0140096,GO:1901564	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
SRR21617310_k127_2276211_2	273116.14325124	3.022e-13	79.0	COG2244@1|root,arCOG02209@2157|Archaea,2Y7AT@28890|Euryarchaeota,24273@183967|Thermoplasmata	183967|Thermoplasmata	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
SRR21617310_k127_2276211_0	515635.Dtur_0351	4.337e-131	425.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	4.1.1.35,4.2.1.46,5.1.3.2,5.1.3.6	ko:K01710,ko:K01784,ko:K08678,ko:K08679	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R01384,R01385,R02984,R06513	RC00289,RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SRR21617310_k127_2276211_1	515635.Dtur_0352	8.994e-108	357.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	1.1.1.271,5.1.3.2,6.3.5.5	ko:K01784,ko:K01955,ko:K02377	ko00051,ko00052,ko00240,ko00250,ko00520,ko01100,map00051,map00052,map00240,map00250,map00520,map01100	M00051,M00361,M00362,M00632	R00256,R00291,R00575,R01395,R02984,R05692,R10948,R10949	RC00002,RC00010,RC00043,RC00289,RC01014,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
SRR21617310_k127_227709_0	589924.Ferp_1036	5.824e-50	179.0	COG0183@1|root,arCOG01278@2157|Archaea,2XVUA@28890|Euryarchaeota,2460R@183980|Archaeoglobi	183980|Archaeoglobi	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRR21617310_k127_227709_1	1448860.BBJO01000042_gene1779	2.19e-46	171.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXD4@28890|Euryarchaeota,23VSD@183963|Halobacteria	183963|Halobacteria	V	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SRR21617310_k127_227709_3	240302.BN982_00681	3.129e-30	132.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,4H9TB@91061|Bacilli,3NDVD@45667|Halobacillus	91061|Bacilli	K	ParB-like nuclease domain	spo0J	GO:0005575,GO:0005622,GO:0005623,GO:0007059,GO:0008150,GO:0009295,GO:0009987,GO:0022603,GO:0042173,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0043937,GO:0043938,GO:0044424,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	HTH_3,KorB,ParBc
SRR21617310_k127_227709_2	1279009.ADICEAN_00035	4.955e-31	130.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Malectin
SRR21617310_k127_227709_4	118163.Ple7327_2411	5.036e-05	45.0	COG1881@1|root,COG1881@2|Bacteria,1G5SZ@1117|Cyanobacteria,3VN4P@52604|Pleurocapsales	1117|Cyanobacteria	G	Raf kinase inhibitor-like protein, YbhB YbcL family	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
SRR21617310_k127_2306127_2	330779.Saci_0593	1.775e-09	61.0	COG0185@1|root,arCOG04099@2157|Archaea,2XQBR@28889|Crenarchaeota	28889|Crenarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SRR21617310_k127_2306127_0	186497.PF1742	2.214e-142	462.0	COG0438@1|root,arCOG01407@2157|Archaea,2XTJ5@28890|Euryarchaeota,242XN@183968|Thermococci	183968|Thermococci	M	trehalose synthase activity	treT	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
SRR21617310_k127_2306127_1	368408.Tpen_1165	5.584e-13	70.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPUC@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM ABC transporter related	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
SRR21617310_k127_2306177_2	1450525.JATV01000005_gene455	1.764e-86	295.0	COG3177@1|root,COG3177@2|Bacteria,4NESH@976|Bacteroidetes,1HZ51@117743|Flavobacteriia,2NSWR@237|Flavobacterium	976|Bacteroidetes	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
SRR21617310_k127_2306177_1	555079.Toce_0910	8.085e-111	369.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,42ESV@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
SRR21617310_k127_2306177_0	386456.JQKN01000012_gene1035	5.489e-126	412.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,23NSE@183925|Methanobacteria	183925|Methanobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
SRR21617310_k127_2317821_1	661478.OP10G_1220	8.026e-57	206.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
SRR21617310_k127_2317821_3	1286171.EAL2_c06730	1.502e-05	56.0	2AK7A@1|root,31AXF@2|Bacteria,1V92I@1239|Firmicutes,24KFJ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2317821_0	439235.Dalk_1167	3.637e-62	233.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42TFM@68525|delta/epsilon subdivisions,2WPBE@28221|Deltaproteobacteria,2MK7R@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR21617310_k127_2317821_2	374847.Kcr_0567	9.336e-18	88.0	COG1215@1|root,arCOG01389@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
SRR21617310_k127_2317943_1	304371.MCP_1496	2.215e-26	117.0	COG5549@1|root,arCOG04994@2157|Archaea,2Y4E9@28890|Euryarchaeota	28890|Euryarchaeota	O	Matrixin	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2317943_2	223926.28809009	1.321e-10	67.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,1XXN7@135623|Vibrionales	135623|Vibrionales	E	Lactoylglutathione lyase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
SRR21617310_k127_2317943_0	1220534.B655_0941	2.809e-38	145.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
SRR21617310_k127_2320790_2	368408.Tpen_0113	1.205e-50	186.0	COG1208@1|root,arCOG00663@2157|Archaea,2XQ9B@28889|Crenarchaeota	28889|Crenarchaeota	M	COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
SRR21617310_k127_2320790_0	1365176.N186_07075	1.551e-139	463.0	arCOG11614@1|root,arCOG11614@2157|Archaea,2XRPS@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2320790_1	1195236.CTER_2504	3.539e-117	385.0	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,3WH12@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
SRR21617310_k127_2320790_3	374847.Kcr_0148	5.545e-26	115.0	COG0727@1|root,arCOG02579@2157|Archaea	2157|Archaea	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SRR21617310_k127_2322610_2	1502851.FG93_01142	1.516e-13	81.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
SRR21617310_k127_2322610_1	768706.Desor_4153	4.225e-53	194.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia	186801|Clostridia	S	TIGRFAM methyltransferase cognate corrinoid proteins, Methanosarcina family	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
SRR21617310_k127_2322610_0	768706.Desor_2732	6.783e-57	214.0	COG5598@1|root,COG5598@2|Bacteria,1TR30@1239|Firmicutes,24ZPQ@186801|Clostridia	186801|Clostridia	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SRR21617310_k127_232838_0	589924.Ferp_1748	1.293e-111	374.0	COG0633@1|root,COG3894@1|root,arCOG02035@2157|Archaea,arCOG02842@2157|Archaea,2XVBE@28890|Euryarchaeota,246NQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
SRR21617310_k127_232838_1	573061.Clocel_1248	6.472e-58	209.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,36IFT@31979|Clostridiaceae	186801|Clostridia	S	PFAM Methionine synthase, B12-binding module, cap domain protein	mtbC	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
SRR21617310_k127_232838_2	339860.Msp_0182	4.968e-52	197.0	COG0407@1|root,arCOG03323@2157|Archaea,2Y8J0@28890|Euryarchaeota,23NVD@183925|Methanobacteria	28890|Euryarchaeota	H	Methylcobalamin coenzyme M methyltransferase	-	-	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
SRR21617310_k127_232838_3	192952.MM_1070	3.505e-31	126.0	COG0407@1|root,arCOG03324@2157|Archaea,2XVT1@28890|Euryarchaeota,2NA2I@224756|Methanomicrobia	224756|Methanomicrobia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	2.1.1.246	ko:K14080	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R09098,R10000	RC00035,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1054	URO-D
SRR21617310_k127_2340340_3	1070774.J07HN4v3_00427	0.0001525	47.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,23SMY@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulator with C-terminal CBS domains	cbs8	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3,HTH_31
SRR21617310_k127_2340340_2	1220534.B655_0937	1.057e-16	85.0	arCOG01917@1|root,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3,zinc_ribbon_2
SRR21617310_k127_2340340_0	1220534.B655_0941	1.116e-188	599.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
SRR21617310_k127_2393332_5	269797.Mbar_A2220	3.393e-55	200.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9DW@224756|Methanomicrobia	224756|Methanomicrobia	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SRR21617310_k127_2393332_2	1459636.NTE_00452	1.983e-90	308.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
SRR21617310_k127_2393332_0	1459636.NTE_00046	1.296e-109	366.0	COG0226@1|root,arCOG08033@1|root,arCOG00213@2157|Archaea,arCOG08033@2157|Archaea,41SXU@651137|Thaumarchaeota	651137|Thaumarchaeota	P	TIGRFAM phosphate ABC transporter	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
SRR21617310_k127_2393332_1	768704.Desmer_2751	5.798e-91	309.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,26553@186807|Peptococcaceae	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SRR21617310_k127_2393332_3	649747.HMPREF0083_00885	3.451e-67	238.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,4HAKF@91061|Bacilli,26U7E@186822|Paenibacillaceae	91061|Bacilli	P	Phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
SRR21617310_k127_2393332_4	436308.Nmar_0483	2.652e-63	222.0	COG1117@1|root,arCOG00231@2157|Archaea,41SYJ@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
SRR21617310_k127_2399834_2	368408.Tpen_0135	2.622e-09	63.0	COG1449@1|root,arCOG03278@2157|Archaea,2XQ1R@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
SRR21617310_k127_2399834_1	693661.Arcve_0376	4.725e-19	93.0	COG0517@1|root,arCOG00606@2157|Archaea,2XZ4H@28890|Euryarchaeota,246CU@183980|Archaeoglobi	183980|Archaeoglobi	S	signal transduction protein with CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
SRR21617310_k127_2399834_0	374847.Kcr_0743	4.195e-57	210.0	arCOG04032@1|root,arCOG04032@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2410931_2	456320.Mvol_1056	4.777e-09	57.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23R03@183939|Methanococci	183939|Methanococci	J	Belongs to the SUI1 family	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
SRR21617310_k127_2410931_1	1041930.Mtc_2048	1.356e-115	385.0	COG0842@1|root,arCOG01463@2157|Archaea,2XVQJ@28890|Euryarchaeota,2NB7X@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SRR21617310_k127_2410931_0	1041930.Mtc_2047	7.455e-117	386.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBN9@224756|Methanomicrobia	224756|Methanomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR21617310_k127_2425978_1	589865.DaAHT2_0376	9.001e-57	206.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2WITE@28221|Deltaproteobacteria,2MK2A@213118|Desulfobacterales	28221|Deltaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
SRR21617310_k127_2425978_0	1131266.ARWQ01000003_gene1564	8.968e-74	258.0	COG0463@1|root,arCOG00894@2157|Archaea,41T1Z@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR21617310_k127_2427125_0	589924.Ferp_2499	2.291e-77	267.0	COG1180@1|root,arCOG00947@2157|Archaea,2XWY1@28890|Euryarchaeota,246TQ@183980|Archaeoglobi	183980|Archaeoglobi	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
SRR21617310_k127_2427125_2	192952.MM_1353	1.284e-26	122.0	COG0620@1|root,arCOG01878@2157|Archaea,2XWEP@28890|Euryarchaeota,2NA99@224756|Methanomicrobia	224756|Methanomicrobia	E	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1023	-
SRR21617310_k127_2427125_1	374847.Kcr_0043	6.06e-55	205.0	COG0611@1|root,arCOG00638@2157|Archaea	2157|Archaea	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006725,GO:0006732,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
SRR21617310_k127_2435574_6	1380390.JIAT01000014_gene6078	5.941e-05	48.0	COG1363@1|root,COG1363@2|Bacteria,2I6I7@201174|Actinobacteria,4CRBK@84995|Rubrobacteria	84995|Rubrobacteria	G	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
SRR21617310_k127_2435574_2	1459636.NTE_02288	4.425e-98	332.0	COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF1512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
SRR21617310_k127_2435574_7	985053.VMUT_0137	0.000737	48.0	arCOG03770@1|root,arCOG03770@2157|Archaea	2157|Archaea	M	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2435574_4	1459636.NTE_02290	7.041e-75	262.0	COG0024@1|root,arCOG01001@2157|Archaea,41SEA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
SRR21617310_k127_2435574_5	589924.Ferp_2520	2.81e-32	133.0	COG1853@1|root,arCOG02017@2157|Archaea,2Y8H7@28890|Euryarchaeota,2476R@183980|Archaeoglobi	183980|Archaeoglobi	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
SRR21617310_k127_2435574_3	868131.MSWAN_1746	1.003e-92	317.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,23NWJ@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
SRR21617310_k127_2435574_1	386456.JQKN01000002_gene2422	3.216e-125	417.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,23NUT@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
SRR21617310_k127_2435574_0	868131.MSWAN_1300	3.063e-134	443.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,23NX2@183925|Methanobacteria	183925|Methanobacteria	J	Phenylalanyl-tRNA synthetase beta	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
SRR21617310_k127_2438466_0	985053.VMUT_0271	3.51e-14	79.0	arCOG01214@1|root,arCOG01214@2157|Archaea,2XR4Q@28889|Crenarchaeota	28889|Crenarchaeota	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3,Trehalose_PPase
SRR21617310_k127_2438466_1	1459636.NTE_02444	1.675e-07	57.0	arCOG01214@1|root,arCOG01214@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3,Trehalose_PPase
SRR21617310_k127_2438466_2	1094980.Mpsy_2169	1.773e-06	55.0	arCOG07522@1|root,arCOG07522@2157|Archaea,2Y1I3@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2438987_5	1286170.RORB6_16680	1.715e-07	53.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine	dcyD	-	4.4.1.15,4.4.1.25	ko:K05396,ko:K17950	ko00270,map00270	-	R01874,R07634	RC00382,RC01784	ko00000,ko00001,ko01000	-	-	-	PALP
SRR21617310_k127_2438987_4	1163730.FFONT_1371	5.782e-12	73.0	arCOG00552@1|root,arCOG00552@2157|Archaea,2XR6J@28889|Crenarchaeota	28889|Crenarchaeota	L	GINS complex protein	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
SRR21617310_k127_2438987_1	415426.Hbut_0903	1.843e-182	593.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
SRR21617310_k127_2438987_0	1094980.Mpsy_2704	4.732e-187	609.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
SRR21617310_k127_2438987_2	342949.PNA2_1866	1.485e-131	435.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,24385@183968|Thermococci	183968|Thermococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
SRR21617310_k127_2438987_3	693661.Arcve_1325	3.386e-60	226.0	COG0367@1|root,COG0449@1|root,arCOG00057@2157|Archaea,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota	28890|Euryarchaeota	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_6,GATase_7
SRR21617310_k127_2442654_0	1229909.NSED_05285	2.996e-154	503.0	COG4962@1|root,arCOG01817@2157|Archaea,41T25@651137|Thaumarchaeota	651137|Thaumarchaeota	N	COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
SRR21617310_k127_2442654_1	1229909.NSED_05290	1.165e-32	139.0	COG2064@1|root,arCOG01808@2157|Archaea	2157|Archaea	NU	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
SRR21617310_k127_2451582_2	565653.EGBG_02869	0.0008562	43.0	COG0517@1|root,COG0517@2|Bacteria,1TRZD@1239|Firmicutes,4HC4C@91061|Bacilli,4B076@81852|Enterococcaceae	91061|Bacilli	K	Domain in cystathionine beta-synthase and other proteins.	ccpN	GO:0006355,GO:0007154,GO:0007584,GO:0008150,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0042221,GO:0045013,GO:0045892,GO:0045934,GO:0045990,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	CBS,HTH_11
SRR21617310_k127_2451582_0	456442.Mboo_1285	4.034e-313	981.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SRR21617310_k127_2451582_1	436308.Nmar_1706	5.418e-07	56.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
SRR21617310_k127_2462985_1	1094980.Mpsy_0710	5.117e-114	384.0	COG0677@1|root,arCOG00252@2157|Archaea,2Y2A7@28890|Euryarchaeota,2NA83@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SRR21617310_k127_2462985_0	269797.Mbar_A2696	2.139e-167	536.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRR21617310_k127_2477066_2	267377.MMP0230	2.989e-34	141.0	COG3481@1|root,arCOG01861@2157|Archaea,2XW7M@28890|Euryarchaeota,23Q6Q@183939|Methanococci	183939|Methanococci	H	PFAM metal-dependent phosphohydrolase, HD sub domain	-	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.1.4.56	ko:K17487	ko00790,map00790	-	R10344,R10345	RC00763,RC03130	ko00000,ko00001,ko01000	-	-	-	HD
SRR21617310_k127_2477066_1	368408.Tpen_0682	2.333e-61	218.0	COG1515@1|root,arCOG00929@2157|Archaea,2XQNE@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
SRR21617310_k127_2477066_3	269797.Mbar_A1205	9.187e-30	126.0	COG2178@1|root,arCOG04318@2157|Archaea,2XYD0@28890|Euryarchaeota,2N9Q9@224756|Methanomicrobia	224756|Methanomicrobia	J	RNA-binding protein of the translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
SRR21617310_k127_2477066_0	453591.Igni_1433	1.842e-100	336.0	COG0731@1|root,arCOG04174@2157|Archaea,2XPM3@28889|Crenarchaeota	28889|Crenarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
SRR21617310_k127_250320_4	186497.PF1396	4.658e-26	115.0	COG1893@1|root,arCOG04139@2157|Archaea,2XTBD@28890|Euryarchaeota,243P9@183968|Thermococci	183968|Thermococci	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
SRR21617310_k127_250320_2	1123274.KB899428_gene1837	9.031e-75	259.0	COG0413@1|root,COG0413@2|Bacteria,2J6TG@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
SRR21617310_k127_250320_0	1459636.NTE_02602	9.826e-125	412.0	COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
SRR21617310_k127_250320_3	386456.JQKN01000001_gene2010	1.14e-29	125.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,23P4J@183925|Methanobacteria	183925|Methanobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
SRR21617310_k127_250320_1	1220534.B655_1877	1.729e-85	289.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,23PHY@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
SRR21617310_k127_2509765_3	391735.Veis_0867	3.805e-10	67.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,4AAIF@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sulfate ABC transporter inner membrane subunit CysT	cysT	-	-	ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5	-	-	BPD_transp_1
SRR21617310_k127_2509765_0	1459636.NTE_00656	1.319e-128	420.0	COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
SRR21617310_k127_2509765_1	573064.Mefer_0805	3.218e-41	161.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,23QD7@183939|Methanococci	183939|Methanococci	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SRR21617310_k127_2509765_5	33876.JNXY01000037_gene8033	3.86e-06	51.0	COG0454@1|root,COG0456@2|Bacteria,2INMX@201174|Actinobacteria,4DE01@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRR21617310_k127_2509765_2	1869.MB27_37360	5.467e-12	70.0	COG0454@1|root,COG0456@2|Bacteria,2INMX@201174|Actinobacteria,4DE01@85008|Micromonosporales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRR21617310_k127_2509765_4	1163730.FFONT_0168	2.429e-08	57.0	COG0467@1|root,arCOG01171@2157|Archaea,2XPNC@28889|Crenarchaeota	28889|Crenarchaeota	T	Belongs to the UPF0273 family	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
SRR21617310_k127_2511117_2	1122138.AQUZ01000059_gene3941	4.212e-14	76.0	COG3535@1|root,COG3535@2|Bacteria,2HJF5@201174|Actinobacteria,4DSA5@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF917)	-	-	-	ko:K09703	-	-	-	-	ko00000	-	-	-	DUF917
SRR21617310_k127_2511117_0	661478.OP10G_3316	2.952e-98	332.0	COG1260@1|root,COG1260@2|Bacteria	2|Bacteria	I	inositol-3-phosphate synthase activity	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
SRR21617310_k127_2511117_1	868131.MSWAN_1472	6.485e-55	205.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota,23NTH@183925|Methanobacteria	183925|Methanobacteria	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
SRR21617310_k127_2517112_4	673860.AciM339_0352	4.912e-37	144.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,3F37E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
SRR21617310_k127_2517112_2	1365176.N186_07010	1.579e-70	244.0	COG1418@1|root,arCOG01860@2157|Archaea,2XQDI@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SRR21617310_k127_2517112_1	767817.Desgi_0510	9.06e-141	456.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,261FM@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SRR21617310_k127_2517112_0	1379698.RBG1_1C00001G0895	5.964e-177	565.0	COG1775@1|root,COG1775@2|Bacteria	2|Bacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
SRR21617310_k127_2517112_3	767817.Desgi_1429	9.051e-46	171.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,261IU@186807|Peptococcaceae	186801|Clostridia	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
SRR21617310_k127_2533912_0	593750.Metfor_1717	1.576e-156	508.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
SRR21617310_k127_2533912_1	1304874.JAFY01000002_gene577	2.22e-91	318.0	COG5598@1|root,COG5598@2|Bacteria,3TC8U@508458|Synergistetes	508458|Synergistetes	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
SRR21617310_k127_2533912_2	192952.MM_1690	1.135e-46	176.0	COG5012@1|root,arCOG02028@2157|Archaea,2XX6R@28890|Euryarchaeota,2NA0S@224756|Methanomicrobia	224756|Methanomicrobia	S	Acts probably as a methyl group carrier between MttB and either MtbA or MtaA	-	-	-	ko:K14084	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124	RC00035,RC00732,RC02984	ko00000,ko00001,ko00002	-	-	-	B12-binding,B12-binding_2
SRR21617310_k127_2533912_3	1340434.AXVA01000004_gene2790	2.446e-22	110.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HA0E@91061|Bacilli,1ZDF1@1386|Bacillus	91061|Bacilli	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
SRR21617310_k127_2533912_4	1410620.SHLA_17c000470	8.926e-06	51.0	COG5598@1|root,COG5598@2|Bacteria,1N18H@1224|Proteobacteria,2TRUE@28211|Alphaproteobacteria,4BIG0@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SRR21617310_k127_254003_9	237368.SCABRO_01576	2.951e-15	79.0	COG1207@1|root,COG1207@2|Bacteria	2|Bacteria	M	glucosamine-1-phosphate N-acetyltransferase activity	glmU	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_4
SRR21617310_k127_254003_1	386456.JQKN01000002_gene2393	4.048e-152	501.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,23NRN@183925|Methanobacteria	183925|Methanobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
SRR21617310_k127_254003_2	374847.Kcr_1249	4.958e-134	440.0	COG1350@1|root,arCOG01432@2157|Archaea	2157|Archaea	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRR21617310_k127_254003_0	1365176.N186_04140	2.577e-173	554.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPMC@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SRR21617310_k127_254003_8	386456.JQKN01000008_gene1505	3.18e-25	109.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,23PPK@183925|Methanobacteria	183925|Methanobacteria	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
SRR21617310_k127_254003_4	374847.Kcr_1293	1.955e-101	338.0	COG1013@1|root,arCOG01601@2157|Archaea	2157|Archaea	C	PFAM Thiamine pyrophosphate	vorB	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
SRR21617310_k127_254003_3	391623.TERMP_01558	4.187e-128	422.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,242N1@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorA	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
SRR21617310_k127_254003_7	351160.RRC110	2.254e-28	117.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota,2NB3N@224756|Methanomicrobia	224756|Methanomicrobia	C	oxidoreductase, delta subunit	porD-2	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
SRR21617310_k127_254003_5	69014.TK1978	1.065e-60	214.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,243DZ@183968|Thermococci	183968|Thermococci	C	pyruvate synthase activity	porG	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SRR21617310_k127_254003_10	1457250.BBMO01000002_gene2811	3.314e-15	88.0	COG2309@1|root,arCOG01888@2157|Archaea,2XSUA@28890|Euryarchaeota,23TKX@183963|Halobacteria	183963|Halobacteria	E	Leucyl aminopeptidase (Aminopeptidase T)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SRR21617310_k127_254003_6	591019.Shell_1002	3.171e-58	209.0	COG1014@1|root,arCOG01603@2157|Archaea,2XQ6Y@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
SRR21617310_k127_2541185_0	351160.RCIX924	1.091e-28	126.0	COG1011@1|root,arCOG02291@2157|Archaea	2157|Archaea	S	hydrolase (HAD superfamily)	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SRR21617310_k127_2543128_10	760568.Desku_1396	1.995e-38	152.0	COG1085@1|root,COG1085@2|Bacteria,1V675@1239|Firmicutes,24JTF@186801|Clostridia,263QP@186807|Peptococcaceae	186801|Clostridia	C	galactose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2543128_2	415426.Hbut_1178	8.525e-145	481.0	COG0018@1|root,arCOG00487@2157|Archaea,2XPXC@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
SRR21617310_k127_2543128_1	436308.Nmar_0578	2.376e-161	525.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
SRR21617310_k127_2543128_11	1220534.B655_1529	2.575e-20	94.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,23P5R@183925|Methanobacteria	183925|Methanobacteria	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
SRR21617310_k127_2543128_8	529709.PYCH_07510	4.523e-48	176.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2441P@183968|Thermococci	183968|Thermococci	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
SRR21617310_k127_2543128_9	635013.TherJR_1734	5.513e-39	162.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,260PT@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SRR21617310_k127_2543128_7	342949.PNA2_0765	2.642e-73	265.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
SRR21617310_k127_2543128_3	1151117.AJLF01000002_gene132	8.991e-123	401.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,242WA@183968|Thermococci	183968|Thermococci	F	Aspartate carbamoyltransferase	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SRR21617310_k127_2543128_0	269797.Mbar_A1037	5.236e-269	848.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
SRR21617310_k127_2543128_12	670487.Ocepr_0567	9.213e-06	52.0	COG2217@1|root,COG2217@2|Bacteria,1WJ55@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	pacS	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
SRR21617310_k127_2543128_4	573064.Mefer_0922	3.639e-116	402.0	COG1328@1|root,arCOG03714@1|root,arCOG03714@2157|Archaea,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,23Q3Z@183939|Methanococci	183939|Methanococci	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,NRDD
SRR21617310_k127_2543128_6	70601.3257229	7.98e-81	287.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,243ZB@183968|Thermococci	183968|Thermococci	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR21617310_k127_2543128_5	580327.Tthe_2716	1.629e-100	332.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,42FH5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
SRR21617310_k127_2548788_5	529709.PYCH_14980	9.027e-08	63.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2432S@183968|Thermococci	183968|Thermococci	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
SRR21617310_k127_2548788_2	426368.MmarC7_0396	3.505e-89	312.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,23Q7H@183939|Methanococci	183939|Methanococci	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
SRR21617310_k127_2548788_3	192952.MM_0144	4.758e-75	270.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
SRR21617310_k127_2548788_1	386456.JQKN01000003_gene419	3.233e-93	318.0	COG4030@1|root,arCOG01161@2157|Archaea,2XWWH@28890|Euryarchaeota,23NXN@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF2961)	ehaR	-	-	ko:K14109	-	-	-	-	ko00000	-	-	-	-
SRR21617310_k127_2548788_0	572546.Arcpr_0160	8.757e-110	362.0	COG2037@1|root,arCOG02695@2157|Archaea,2XUV2@28890|Euryarchaeota,246VK@183980|Archaeoglobi	183980|Archaeoglobi	H	PFAM Formylmethanofuran tetrahydromethanopterin formyltransferase Ftr	-	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
SRR21617310_k127_2548788_4	868131.MSWAN_0959	4.501e-50	184.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,23NZS@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
SRR21617310_k127_2552947_2	385682.AFSL01000063_gene1531	3.212e-15	76.0	COG1379@1|root,COG1379@2|Bacteria,4NM08@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2552947_1	1459636.NTE_01641	4.231e-18	92.0	arCOG03119@1|root,arCOG03119@2157|Archaea,41SMJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
SRR21617310_k127_2552947_0	1232437.KL661978_gene3851	1.089e-302	943.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SRR21617310_k127_2572021_1	647113.Metok_0159	7.761e-30	123.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,23Q6M@183939|Methanococci	183939|Methanococci	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
SRR21617310_k127_2572021_0	515635.Dtur_1425	1.325e-62	220.0	COG2236@1|root,COG2236@2|Bacteria	2|Bacteria	F	xanthine phosphoribosyltransferase activity	gpt	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
SRR21617310_k127_2621076_6	1538644.KO02_19090	6.591e-06	53.0	COG1996@1|root,COG1996@2|Bacteria,4NFZ3@976|Bacteroidetes,1IRQE@117747|Sphingobacteriia	976|Bacteroidetes	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2621076_1	391589.RGAI101_1698	3.649e-45	172.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2P1PW@2433|Roseobacter	28211|Alphaproteobacteria	S	membrane protein (homolog of Drosophila rhomboid)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
SRR21617310_k127_2621076_2	374847.Kcr_1160	2.539e-41	160.0	arCOG01879@1|root,arCOG01879@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2621076_3	386456.JQKN01000001_gene1847	2.585e-41	166.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,23PGN@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	EF-hand_5,Peptidase_M48
SRR21617310_k127_2621076_0	1459636.NTE_02001	1.878e-68	243.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR21617310_k127_2621076_4	985053.VMUT_1693	7.706e-15	83.0	COG0842@1|root,arCOG01469@2157|Archaea,2XRBH@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
SRR21617310_k127_2621076_5	1198449.ACAM_1438	1.996e-08	57.0	COG1236@1|root,arCOG00545@2157|Archaea,2XQ4Z@28889|Crenarchaeota	28889|Crenarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_3
SRR21617310_k127_2624785_1	1379698.RBG1_1C00001G1133	2.2e-60	216.0	COG1575@1|root,COG1575@2|Bacteria,2NPNN@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
SRR21617310_k127_2624785_2	877455.Metbo_0434	1.452e-12	76.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y782@28890|Euryarchaeota,23P3B@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
SRR21617310_k127_2624785_0	243232.MJ_0217	2.022e-202	646.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,23Q05@183939|Methanococci	183939|Methanococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
SRR21617310_k127_2631302_2	573064.Mefer_0653	2.896e-40	156.0	COG0243@1|root,arCOG01491@2157|Archaea,2XT94@28890|Euryarchaeota,23QFK@183939|Methanococci	183939|Methanococci	C	Molybdopterin oxidoreductase Fe4S4 region	-	-	1.17.1.9,1.7.7.2	ko:K00123,ko:K00367	ko00630,ko00680,ko00910,ko01100,ko01120,ko01200,map00630,map00680,map00910,map01100,map01120,map01200	M00531	R00519,R00791	RC02796,RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SRR21617310_k127_2631302_3	604354.TSIB_1973	5.148e-38	149.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
SRR21617310_k127_2631302_4	985053.VMUT_0438	7.831e-26	114.0	COG0494@1|root,arCOG01072@2157|Archaea,2XRJY@28889|Crenarchaeota	28889|Crenarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
SRR21617310_k127_2631302_1	1540257.JQMW01000013_gene1161	1.972e-97	327.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,36DCB@31979|Clostridiaceae	186801|Clostridia	C	glycyl-radical enzyme activating protein family	csdA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
SRR21617310_k127_2631302_0	1047013.AQSP01000101_gene607	1.766e-100	333.0	COG1882@1|root,COG1882@2|Bacteria,2NQDK@2323|unclassified Bacteria	2|Bacteria	C	Pyruvate formate lyase-like	pflD	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
SRR21617310_k127_2634888_0	572546.Arcpr_0782	6.591e-06	53.0	COG3432@1|root,arCOG01055@2157|Archaea,2Y23V@28890|Euryarchaeota	28890|Euryarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_2634888_2	760568.Desku_1174	0.0002093	53.0	COG1388@1|root,COG1388@2|Bacteria,1UJSB@1239|Firmicutes,24MVZ@186801|Clostridia	186801|Clostridia	M	Intracellular proteinase inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	BsuPI,LysM
SRR21617310_k127_2634888_1	768706.Desor_3591	9.605e-06	52.0	COG2318@1|root,COG2318@2|Bacteria,1V51W@1239|Firmicutes	1239|Firmicutes	S	DinB family	dinB	-	-	-	-	-	-	-	-	-	-	-	DinB
SRR21617310_k127_2646515_3	357809.Cphy_0184	2.6e-06	52.0	28Q1F@1|root,2ZCJT@2|Bacteria,1VI7R@1239|Firmicutes,24D4W@186801|Clostridia,2216K@1506553|Lachnoclostridium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2646515_1	545693.BMQ_3853	7.177e-89	303.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli,1ZQGD@1386|Bacillus	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
SRR21617310_k127_2646515_2	985665.HPL003_07220	3.818e-41	162.0	COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,4HEMY@91061|Bacilli,276B1@186822|Paenibacillaceae	91061|Bacilli	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR21617310_k127_2646515_0	192952.MM_2931	1.958e-169	539.0	COG0607@1|root,arCOG00517@1|root,arCOG00517@2157|Archaea,arCOG02021@2157|Archaea,2XSV0@28890|Euryarchaeota,2N97K@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese-like domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
SRR21617310_k127_2673122_0	562970.Btus_1077	4.338e-80	281.0	COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,4HA14@91061|Bacilli,2788B@186823|Alicyclobacillaceae	91061|Bacilli	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
SRR21617310_k127_2673122_1	1220534.B655_1893	4.9e-08	57.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SRR21617310_k127_2678829_1	269797.Mbar_A3389	2.112e-50	187.0	COG0535@1|root,arCOG00955@2157|Archaea,2Y8D1@28890|Euryarchaeota,2NASP@224756|Methanomicrobia	224756|Methanomicrobia	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
SRR21617310_k127_2678829_3	649831.L083_5318	2.364e-06	55.0	2FJMA@1|root,34BAM@2|Bacteria,2IBW2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4760
SRR21617310_k127_2678829_0	489825.LYNGBM3L_30250	2.682e-101	335.0	COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,1H9U9@1150|Oscillatoriales	1117|Cyanobacteria	C	NADPH quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
SRR21617310_k127_2685801_1	572546.Arcpr_1724	8.549e-56	206.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota,246Y8@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
SRR21617310_k127_2685801_2	243164.DET0352	3.021e-29	136.0	COG3103@1|root,COG4991@2|Bacteria,2G9F6@200795|Chloroflexi,34D2H@301297|Dehalococcoidia	301297|Dehalococcoidia	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TIG
SRR21617310_k127_2685801_4	387631.Asulf_00226	3.995e-09	61.0	COG1594@1|root,arCOG00579@2157|Archaea,2XY3E@28890|Euryarchaeota,2473M@183980|Archaeoglobi	183980|Archaeoglobi	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
SRR21617310_k127_2685801_0	177437.HRM2_17530	6.888e-117	389.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MHKF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRR21617310_k127_2685801_6	679926.Mpet_1510	5.974e-05	51.0	COG1695@1|root,arCOG00002@2157|Archaea,2Y1PS@28890|Euryarchaeota,2NBA8@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SRR21617310_k127_2685801_3	97139.C824_03486	1.207e-17	86.0	COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,24QYU@186801|Clostridia,36KS5@31979|Clostridiaceae	186801|Clostridia	L	Excinuclease ABC C subunit domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
SRR21617310_k127_2685801_5	1131266.ARWQ01000002_gene601	1.884e-05	48.0	COG1656@1|root,arCOG04290@2157|Archaea,41T6F@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Mut7-C RNAse domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2706186_1	273116.14325498	3.327e-08	58.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y7BB@28890|Euryarchaeota,242B4@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
SRR21617310_k127_2706186_0	1459636.NTE_02069	7.375e-10	66.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_2706186_2	1121930.AQXG01000002_gene2195	7.55e-05	52.0	2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4382
SRR21617310_k127_2706186_3	1131266.ARWQ01000002_gene577	0.000359	49.0	arCOG11516@1|root,arCOG11516@2157|Archaea,41T9Y@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2730864_3	368407.Memar_0626	1.196e-20	98.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
SRR21617310_k127_2730864_0	760568.Desku_0587	1.605e-155	511.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260S3@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SRR21617310_k127_2730864_2	574087.Acear_1518	2.579e-33	134.0	COG1142@1|root,COG1142@2|Bacteria,1VCTD@1239|Firmicutes,24EHU@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S	hycB3	-	-	ko:K00196,ko:K05796,ko:K12136	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Fer4_11,Fer4_3,Fer4_4,Fer4_6,Fer4_7,Fer4_9
SRR21617310_k127_2730864_1	644281.MFS40622_0209	3.691e-37	142.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
SRR21617310_k127_2735270_11	1469245.JFBG01000083_gene220	1.937e-26	112.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales	135613|Chromatiales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
SRR21617310_k127_2735270_6	186497.PF1982	2.322e-47	180.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,243DT@183968|Thermococci	183968|Thermococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
SRR21617310_k127_2735270_19	1198449.ACAM_0706	3.091e-08	59.0	COG1534@1|root,arCOG01346@2157|Archaea,2XRFX@28889|Crenarchaeota	28889|Crenarchaeota	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
SRR21617310_k127_2735270_14	604354.TSIB_1398	2.572e-17	85.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,244AW@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
SRR21617310_k127_2735270_2	415426.Hbut_1592	2.286e-63	225.0	COG1756@1|root,arCOG04122@2157|Archaea,2XQJ6@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
SRR21617310_k127_2735270_17	69014.TK0477	1.235e-11	73.0	COG1011@1|root,arCOG02291@2157|Archaea,2XWYR@28890|Euryarchaeota,243P8@183968|Thermococci	183968|Thermococci	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SRR21617310_k127_2735270_9	263820.PTO0762	2.476e-33	139.0	arCOG06964@1|root,arCOG06964@2157|Archaea	2157|Archaea	S	Peptidase A4 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A4
SRR21617310_k127_2735270_15	1459636.NTE_03460	2.415e-14	78.0	COG0589@1|root,arCOG02053@2157|Archaea,41T7V@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
SRR21617310_k127_2735270_0	292415.Tbd_0674	2.131e-83	292.0	COG0477@1|root,COG2814@2|Bacteria,1RB5E@1224|Proteobacteria,2VQNK@28216|Betaproteobacteria,1KSII@119069|Hydrogenophilales	119069|Hydrogenophilales	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
SRR21617310_k127_2735270_8	1343739.PAP_02240	7.08e-36	144.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2441S@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
SRR21617310_k127_2735270_5	573063.Metin_1443	3.245e-55	197.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23QV5@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
SRR21617310_k127_2735270_4	272844.PAB1166	2.529e-56	203.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,242ZJ@183968|Thermococci	183968|Thermococci	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
SRR21617310_k127_2735270_3	694429.Pyrfu_0990	8.631e-58	211.0	COG0244@1|root,arCOG04288@2157|Archaea,2XPMI@28889|Crenarchaeota	28889|Crenarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
SRR21617310_k127_2735270_12	693661.Arcve_0944	2.229e-23	103.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,2476N@183980|Archaeoglobi	183980|Archaeoglobi	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
SRR21617310_k127_2735270_10	79684.XP_005344929.1	3.231e-32	134.0	COG0461@1|root,KOG1377@2759|Eukaryota,38EAF@33154|Opisthokonta,3B9I3@33208|Metazoa,3CTV1@33213|Bilateria,48B70@7711|Chordata,48XQV@7742|Vertebrata,3JC3A@40674|Mammalia,35EXN@314146|Euarchontoglires,4Q4HG@9989|Rodentia	33208|Metazoa	F	Uridine 5'-monophosphate synthase	UMPS	GO:0003674,GO:0003824,GO:0004588,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046112,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.10,4.1.1.23	ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
SRR21617310_k127_2735270_13	1042877.GQS_00850	1.869e-19	96.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,243KR@183968|Thermococci	183968|Thermococci	S	Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
SRR21617310_k127_2735270_16	935845.JADQ01000015_gene3218	6.294e-12	72.0	COG0346@1|root,COG0346@2|Bacteria,1VP7J@1239|Firmicutes,4HVYV@91061|Bacilli,26XIC@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
SRR21617310_k127_2735270_1	673860.AciM339_0717	1.322e-65	239.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,3F2FD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
SRR21617310_k127_2735270_18	273116.14324348	7.001e-09	67.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,241SY@183967|Thermoplasmata	183967|Thermoplasmata	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
SRR21617310_k127_2735270_7	693661.Arcve_2046	1.358e-44	176.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,245XN@183980|Archaeoglobi	183980|Archaeoglobi	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C
SRR21617310_k127_2736655_1	391623.TERMP_00992	4.403e-204	642.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
SRR21617310_k127_2736655_8	368408.Tpen_0838	1.782e-24	106.0	COG2164@1|root,arCOG04488@2157|Archaea	2157|Archaea	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
SRR21617310_k127_2736655_9	1365176.N186_06430	4.317e-09	61.0	COG4901@1|root,arCOG04327@2157|Archaea,2XRD4@28889|Crenarchaeota	28889|Crenarchaeota	J	S25 ribosomal protein	rps25e	-	-	ko:K02975	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S25
SRR21617310_k127_2736655_3	386456.JQKN01000002_gene2571	4.621e-154	502.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,23NK2@183925|Methanobacteria	183925|Methanobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
SRR21617310_k127_2736655_5	485916.Dtox_1591	1.253e-43	170.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SRR21617310_k127_2736655_4	1459636.NTE_02318	1.036e-58	213.0	COG1378@1|root,arCOG02038@2157|Archaea,41SFR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
SRR21617310_k127_2736655_0	374847.Kcr_0950	6.158e-208	655.0	COG0281@1|root,arCOG00853@2157|Archaea	2157|Archaea	C	malic enzyme	maeB	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
SRR21617310_k127_2736655_2	591019.Shell_1657	2.501e-197	622.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
SRR21617310_k127_2736655_7	1230460.C495_09939	9.298e-35	144.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
SRR21617310_k127_2736655_6	269797.Mbar_A2048	1.679e-39	154.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
SRR21617310_k127_2742919_2	1123278.KB893562_gene3255	1.199e-20	97.0	COG2357@1|root,COG2357@2|Bacteria,4NFMF@976|Bacteroidetes,47P2Z@768503|Cytophagia	976|Bacteroidetes	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM
SRR21617310_k127_2742919_0	529709.PYCH_13670	8.518e-256	818.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,243PB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
SRR21617310_k127_2742919_1	374847.Kcr_0231	1.686e-251	790.0	COG0495@1|root,arCOG00809@2157|Archaea	2157|Archaea	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
SRR21617310_k127_2743446_1	273116.14325261	1.293e-21	104.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,241M8@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
SRR21617310_k127_2743446_2	472759.Nhal_3595	7.628e-13	77.0	28KBH@1|root,2Z9YH@2|Bacteria,1R3W2@1224|Proteobacteria,1RRIT@1236|Gammaproteobacteria,1X0GX@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2743446_0	44689.DDB0190498	4.418e-52	198.0	2ESDX@1|root,2SUZP@2759|Eukaryota,3XEQJ@554915|Amoebozoa	554915|Amoebozoa	S	Papain-like cysteine protease AvrRpt2	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
SRR21617310_k127_2799173_0	1183377.Py04_1400	1.706e-43	167.0	COG0467@1|root,arCOG01174@2157|Archaea,2XV95@28890|Euryarchaeota,243WZ@183968|Thermococci	183968|Thermococci	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
SRR21617310_k127_2799173_1	69014.TK0214	2.846e-16	84.0	COG0243@1|root,arCOG01491@2157|Archaea,2XT94@28890|Euryarchaeota,242NI@183968|Thermococci	183968|Thermococci	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
SRR21617310_k127_2826461_7	643648.Slip_2077	1.973e-29	120.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,42KH4@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
SRR21617310_k127_2826461_9	177437.HRM2_30770	6.389e-17	93.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1PK2R@1224|Proteobacteria,42QD2@68525|delta/epsilon subdivisions,2WKVT@28221|Deltaproteobacteria,2MI3U@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,FlpD,Pyr_redox_2
SRR21617310_k127_2826461_8	224325.AF_1238	2.603e-19	101.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
SRR21617310_k127_2826461_2	269797.Mbar_A2006	3.586e-71	251.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia	224756|Methanomicrobia	L	8-oxoguanine DNA glycosylase domain protein	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
SRR21617310_k127_2826461_4	1449126.JQKL01000012_gene3503	2.032e-59	212.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,269GR@186813|unclassified Clostridiales	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRR21617310_k127_2826461_6	634498.mru_0594	2.475e-34	138.0	COG0622@1|root,arCOG01141@2157|Archaea,2XWQ0@28890|Euryarchaeota,23PK2@183925|Methanobacteria	183925|Methanobacteria	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
SRR21617310_k127_2826461_0	386456.JQKN01000001_gene1783	8.039e-177	567.0	COG0535@1|root,arCOG00940@2157|Archaea,2XTQH@28890|Euryarchaeota,23PEY@183925|Methanobacteria	183925|Methanobacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
SRR21617310_k127_2826461_1	1459636.NTE_02267	1.063e-76	267.0	COG0179@1|root,arCOG00235@2157|Archaea,41S5K@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
SRR21617310_k127_2826461_3	1333523.L593_14970	1.163e-69	252.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y09Y@28890|Euryarchaeota,23Z56@183963|Halobacteria	183963|Halobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
SRR21617310_k127_2826461_5	304371.MCP_0567	6.489e-49	180.0	COG0500@1|root,COG1131@1|root,arCOG00194@2157|Archaea,arCOG04347@2157|Archaea,2XT1I@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
SRR21617310_k127_2845984_1	401526.TcarDRAFT_1837	9.533e-67	236.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,4H2QE@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
SRR21617310_k127_2845984_2	1492737.FEM08_13720	2.001e-18	97.0	COG0318@1|root,COG0318@2|Bacteria,4NDYR@976|Bacteroidetes,1HXTW@117743|Flavobacteriia,2NSZE@237|Flavobacterium	976|Bacteroidetes	IQ	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
SRR21617310_k127_2845984_0	69014.TK2303	8.991e-123	401.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,242UA@183968|Thermococci	183968|Thermococci	O	Belongs to the TCP-1 chaperonin family	ths	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR21617310_k127_2846992_1	985053.VMUT_0238	2.862e-80	273.0	COG1180@1|root,arCOG00946@2157|Archaea,2XPTQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
SRR21617310_k127_2846992_2	1459636.NTE_02621	2.359e-62	224.0	COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
SRR21617310_k127_2846992_0	368408.Tpen_0138	5.289e-82	286.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
SRR21617310_k127_2846992_3	926569.ANT_15720	3.983e-34	133.0	COG0535@1|root,COG0535@2|Bacteria,2G5XT@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
SRR21617310_k127_2849129_3	604354.TSIB_0312	6.179e-05	45.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,243XV@183968|Thermococci	183968|Thermococci	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
SRR21617310_k127_2849129_2	1220534.B655_1487	5.661e-08	60.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23P4B@183925|Methanobacteria	183925|Methanobacteria	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
SRR21617310_k127_2849129_0	1229909.NSED_01960	1.593e-40	160.0	COG1102@1|root,arCOG01037@2157|Archaea,41SKS@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
SRR21617310_k127_2849129_1	330779.Saci_0813	6.958e-29	118.0	COG2163@1|root,arCOG04167@2157|Archaea,2XQT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14e
SRR21617310_k127_2853477_1	386456.JQKN01000012_gene1015	2.013e-13	83.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
SRR21617310_k127_2853477_0	1220534.B655_1070	3.921e-155	505.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23NV9@183925|Methanobacteria	183925|Methanobacteria	C	Fumarate reductase succinate dehydrogenase flavoprotein	sdhA	-	1.3.4.1	ko:K18209	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SRR21617310_k127_2858137_1	224325.AF_2307	2.942e-51	187.0	arCOG02723@1|root,arCOG02723@2157|Archaea,2XW9T@28890|Euryarchaeota,246KR@183980|Archaeoglobi	183980|Archaeoglobi	H	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
SRR21617310_k127_2858137_4	323259.Mhun_0080	3.136e-07	57.0	arCOG05291@1|root,arCOG05291@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_2858137_3	673860.AciM339_1383	1.041e-13	78.0	COG1714@1|root,arCOG03633@2157|Archaea,2Y6YZ@28890|Euryarchaeota,3F2YA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
SRR21617310_k127_2858137_2	289376.THEYE_A1018	1.974e-33	134.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
SRR21617310_k127_2858137_0	368408.Tpen_0269	7.271e-148	476.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
SRR21617310_k127_2904468_0	572478.Vdis_0049	1.675e-274	867.0	COG0525@1|root,arCOG00808@2157|Archaea,2XPW9@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
SRR21617310_k127_2904468_1	224719.Abm4_1182	1.34e-70	247.0	COG1235@1|root,arCOG00499@2157|Archaea,2XT48@28890|Euryarchaeota,23NXG@183925|Methanobacteria	183925|Methanobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
SRR21617310_k127_2920270_0	868131.MSWAN_1950	2.965e-90	314.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
SRR21617310_k127_2920270_1	1254432.SCE1572_17685	0.0003741	53.0	COG0515@1|root,COG2203@1|root,COG3829@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YTVN@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Pkinase,PocR,Sigma54_activat
SRR21617310_k127_315644_0	694429.Pyrfu_1864	1.8e-138	451.0	COG0012@1|root,arCOG00357@2157|Archaea,2XPTY@28889|Crenarchaeota	28889|Crenarchaeota	J	GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
SRR21617310_k127_315644_1	573064.Mefer_0013	1.466e-91	308.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,23Q8C@183939|Methanococci	183939|Methanococci	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
SRR21617310_k127_315644_3	292459.STH1696	9.325e-69	242.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia	186801|Clostridia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	mtaP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
SRR21617310_k127_315644_4	1229909.NSED_07770	1.519e-48	189.0	COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
SRR21617310_k127_315644_6	70601.3256520	7.141e-18	94.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,242V1@183968|Thermococci	183968|Thermococci	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_315644_2	415426.Hbut_1337	7.905e-77	264.0	COG1042@1|root,arCOG01338@2157|Archaea,2XQ9M@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
SRR21617310_k127_315644_5	1265505.ATUG01000002_gene1107	3.223e-39	154.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
SRR21617310_k127_319268_4	1463885.KL578430_gene6947	1.093e-35	139.0	COG1670@1|root,COG1670@2|Bacteria,2HE22@201174|Actinobacteria	201174|Actinobacteria	J	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
SRR21617310_k127_319268_3	386456.JQKN01000001_gene1847	2.428e-41	166.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,23PGN@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	EF-hand_5,Peptidase_M48
SRR21617310_k127_319268_5	304371.MCP_0749	2.712e-35	145.0	COG1293@1|root,arCOG01695@2157|Archaea	2157|Archaea	K	RNA-binding protein homologous to eukaryotic snRNP	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF814,FbpA
SRR21617310_k127_319268_2	43989.cce_3486	1.202e-42	165.0	COG2020@1|root,COG2020@2|Bacteria,1G5RJ@1117|Cyanobacteria	1117|Cyanobacteria	O	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
SRR21617310_k127_319268_0	877455.Metbo_0981	2.295e-113	382.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
SRR21617310_k127_323185_1	313612.L8106_07511	1.783e-14	79.0	COG0454@1|root,COG0456@2|Bacteria,1G5VK@1117|Cyanobacteria,1HBE4@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
SRR21617310_k127_323185_0	1157490.EL26_11975	8.245e-86	304.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
SRR21617310_k127_328898_0	1365176.N186_07085	9.765e-95	316.0	COG0543@1|root,arCOG02199@2157|Archaea,2XRSY@28889|Crenarchaeota	28889|Crenarchaeota	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind
SRR21617310_k127_328898_1	309801.trd_0565	8.098e-60	218.0	COG0491@1|root,COG0491@2|Bacteria,2G6KC@200795|Chloroflexi,27Y6V@189775|Thermomicrobia	189775|Thermomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRR21617310_k127_328898_2	368408.Tpen_0269	1.59e-58	207.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
SRR21617310_k127_333789_0	1343739.PAP_09035	3.723e-69	258.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,245CQ@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
SRR21617310_k127_337935_5	1232437.KL662030_gene2458	1.064e-35	141.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria,2MI7J@213118|Desulfobacterales	28221|Deltaproteobacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
SRR21617310_k127_337935_4	1459636.NTE_03124	3.996e-40	164.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
SRR21617310_k127_337935_2	1121472.AQWN01000005_gene2360	4.174e-52	199.0	COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,25ZZA@186807|Peptococcaceae	186801|Clostridia	G	Sugar isomerase (SIS)	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
SRR21617310_k127_337935_6	1459636.NTE_03306	1.247e-26	113.0	COG1958@1|root,arCOG00999@2157|Archaea	2157|Archaea	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
SRR21617310_k127_337935_3	224719.Abm4_1640	2.274e-46	177.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,23P1D@183925|Methanobacteria	183925|Methanobacteria	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
SRR21617310_k127_337935_0	694429.Pyrfu_0098	8.329e-124	415.0	COG0343@1|root,arCOG00989@2157|Archaea,2XPSY@28889|Crenarchaeota	28889|Crenarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
SRR21617310_k127_337935_7	323259.Mhun_2401	2.907e-19	95.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,2N9Q2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
SRR21617310_k127_337935_1	1459636.NTE_03316	3.891e-119	395.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
SRR21617310_k127_337935_8	572546.Arcpr_1020	1.761e-11	68.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota,247C7@183980|Archaeoglobi	183980|Archaeoglobi	O	zinc metalloprotease whose natural substrate is	amzA	GO:0003674,GO:0005488,GO:0008270,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
SRR21617310_k127_360490_0	395964.KE386496_gene1577	3.936e-163	532.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3NAI0@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
SRR21617310_k127_363611_1	697303.Thewi_0618	1.913e-76	267.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,42FKR@68295|Thermoanaerobacterales	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
SRR21617310_k127_363611_0	1121472.AQWN01000004_gene700	1.091e-83	292.0	COG1775@1|root,COG1775@2|Bacteria,1TS7H@1239|Firmicutes,2493U@186801|Clostridia,260S9@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD HgdB	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
SRR21617310_k127_363611_2	933262.AXAM01000036_gene2172	2.934e-31	127.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,2MJS3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
SRR21617310_k127_367188_1	565033.GACE_0502	9.136e-32	132.0	COG1216@1|root,arCOG01383@2157|Archaea,2Y668@28890|Euryarchaeota,247A7@183980|Archaeoglobi	183980|Archaeoglobi	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR21617310_k127_367188_0	1459636.NTE_01123	1.05e-124	427.0	COG0421@1|root,arCOG00050@2157|Archaea	2157|Archaea	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0003674,GO:0003824,GO:0004766,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0050314,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
SRR21617310_k127_380060_4	768710.DesyoDRAFT_1593	0.0006968	44.0	COG0006@1|root,COG0006@2|Bacteria,1TSXE@1239|Firmicutes,248AF@186801|Clostridia,2604W@186807|Peptococcaceae	186801|Clostridia	E	PFAM peptidase M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
SRR21617310_k127_380060_2	515635.Dtur_0802	4.165e-58	208.0	COG1351@1|root,COG1351@2|Bacteria	2|Bacteria	F	thymidylate synthase (FAD) activity	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
SRR21617310_k127_380060_1	1041930.Mtc_2101	8.614e-79	277.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
SRR21617310_k127_380060_3	572478.Vdis_1771	1.435e-06	54.0	COG1977@1|root,arCOG00536@2157|Archaea	2157|Archaea	H	Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
SRR21617310_k127_380060_0	246194.CHY_0789	2.107e-105	357.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
SRR21617310_k127_39063_5	1459636.NTE_01556	2.042e-61	217.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRR21617310_k127_39063_1	1121468.AUBR01000005_gene85	7.792e-90	306.0	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,42F31@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the LDH MDH superfamily. LDH family	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
SRR21617310_k127_39063_0	1041930.Mtc_1593	1.842e-131	426.0	COG0205@1|root,arCOG03640@2157|Archaea,2Y3HN@28890|Euryarchaeota,2NATH@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphofructokinase	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
SRR21617310_k127_39063_10	1459636.NTE_03146	5.913e-48	181.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SRR21617310_k127_39063_18	765177.Desmu_0890	1.91e-18	91.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
SRR21617310_k127_39063_12	529709.PYCH_01590	2.257e-44	166.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,243IZ@183968|Thermococci	183968|Thermococci	J	Ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
SRR21617310_k127_39063_3	384616.Pisl_1306	6.142e-74	255.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
SRR21617310_k127_39063_6	444157.Tneu_1254	1.32e-53	198.0	COG0256@1|root,arCOG04088@2157|Archaea,2XPNF@28889|Crenarchaeota	28889|Crenarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
SRR21617310_k127_39063_14	195522.BD01_2167	1.872e-37	146.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,243Y0@183968|Thermococci	183968|Thermococci	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
SRR21617310_k127_39063_17	1183377.Py04_1689	5.874e-34	137.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,2447U@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
SRR21617310_k127_39063_7	415426.Hbut_1316	1.565e-52	192.0	COG0097@1|root,arCOG04090@2157|Archaea,2XQ9A@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
SRR21617310_k127_39063_9	644281.MFS40622_1741	5.954e-49	177.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,23QZ4@183939|Methanococci	183939|Methanococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
SRR21617310_k127_39063_19	368408.Tpen_0241	4.437e-18	84.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
SRR21617310_k127_39063_8	1163730.FFONT_0507	3.002e-52	190.0	COG0094@1|root,arCOG04092@2157|Archaea,2XQDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
SRR21617310_k127_39063_2	272557.APE_0356.1	1.138e-74	258.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
SRR21617310_k127_39063_15	391623.TERMP_00103	4.73e-35	139.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,2444Y@183968|Thermococci	183968|Thermococci	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
SRR21617310_k127_39063_11	673860.AciM339_1108	1.755e-47	174.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,3F2NF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
SRR21617310_k127_39063_16	1184251.TCELL_0335	9.519e-35	135.0	COG0186@1|root,arCOG04096@2157|Archaea,2XQZ6@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
SRR21617310_k127_39063_20	868131.MSWAN_1462	1.579e-16	82.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
SRR21617310_k127_39063_21	1041930.Mtc_1329	5.572e-10	66.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,2NA4R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
SRR21617310_k127_39063_4	877455.Metbo_0780	1.088e-61	222.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,23NMY@183925|Methanobacteria	183925|Methanobacteria	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
SRR21617310_k127_39063_13	1459636.NTE_01832	1.204e-43	164.0	COG0091@1|root,arCOG04098@2157|Archaea,41SJ4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
SRR21617310_k127_415395_4	342949.PNA2_0207	3.713e-48	181.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2437V@183968|Thermococci	183968|Thermococci	F	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
SRR21617310_k127_415395_2	694429.Pyrfu_0913	5.281e-87	296.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
SRR21617310_k127_415395_3	1343739.PAP_01945	7.91e-70	244.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,242JS@183968|Thermococci	183968|Thermococci	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
SRR21617310_k127_415395_0	386456.JQKN01000001_gene1723	1.727e-132	435.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23NP2@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
SRR21617310_k127_415395_5	273063.STK_20635	1.469e-25	107.0	COG1644@1|root,arCOG04244@2157|Archaea,2XR60@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
SRR21617310_k127_415395_1	374847.Kcr_1049	9.08e-92	311.0	COG2421@1|root,arCOG01004@2157|Archaea	2157|Archaea	C	Acetamidase formamidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
SRR21617310_k127_415395_6	436308.Nmar_1597	0.000945	43.0	COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiD family decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
SRR21617310_k127_424354_1	1343739.PAP_05975	8.14e-86	293.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
SRR21617310_k127_424354_6	1459636.NTE_00103	2.221e-18	88.0	COG0550@1|root,arCOG01527@2157|Archaea,41TBA@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	-
SRR21617310_k127_424354_7	1184251.TCELL_0042	1.115e-06	56.0	COG0550@1|root,COG3582@1|root,arCOG01527@2157|Archaea,arCOG01769@2157|Archaea,2XQ00@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA topoisomerase, type IA, central domain protein	topA	-	5.99.1.2	ko:K03168,ko:K03169	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
SRR21617310_k127_424354_3	579137.Metvu_1168	1.741e-34	138.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,23QZ6@183939|Methanococci	183939|Methanococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
SRR21617310_k127_424354_4	797303.Natpe_1161	3.665e-25	113.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,23TKK@183963|Halobacteria	183963|Halobacteria	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
SRR21617310_k127_424354_5	1041930.Mtc_0663	1.692e-22	106.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_424354_2	178306.PAE2242	5.022e-47	187.0	COG5623@1|root,arCOG04127@2157|Archaea,2XPVW@28889|Crenarchaeota	28889|Crenarchaeota	A	PFAM Molybdopterin guanine dinucleotide synthesis protein B	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
SRR21617310_k127_424354_0	694429.Pyrfu_0813	1.849e-179	574.0	COG0008@1|root,arCOG00402@2157|Archaea,2XPVB@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SRR21617310_k127_42477_2	589924.Ferp_2169	1.045e-33	135.0	COG0727@1|root,arCOG02584@2157|Archaea	2157|Archaea	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
SRR21617310_k127_42477_4	246969.TAM4_1711	2.975e-13	75.0	COG1310@1|root,arCOG01138@2157|Archaea,2Y1J4@28890|Euryarchaeota,244HG@183968|Thermococci	183968|Thermococci	S	JAB/MPN domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
SRR21617310_k127_42477_1	374847.Kcr_0711	1.314e-43	166.0	COG0454@1|root,arCOG00826@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9,SCP2_2
SRR21617310_k127_42477_3	1131266.ARWQ01000002_gene491	4.786e-16	83.0	COG2522@1|root,arCOG00017@2157|Archaea,41SJZ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	-
SRR21617310_k127_42477_0	572546.Arcpr_0144	2.125e-53	192.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,245XN@183980|Archaeoglobi	183980|Archaeoglobi	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C
SRR21617310_k127_436296_1	224325.AF_0075	4.237e-19	91.0	COG0608@1|root,arCOG00427@2157|Archaea,2Y2ZU@28890|Euryarchaeota,246X7@183980|Archaeoglobi	183980|Archaeoglobi	L	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_436296_0	351160.LRC224	2.706e-125	411.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,2NADB@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
SRR21617310_k127_437778_4	1365176.N186_07575	5.424e-60	217.0	COG0747@1|root,arCOG01534@2157|Archaea,2XPZY@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
SRR21617310_k127_437778_1	309803.CTN_1426	3.635e-101	340.0	COG0601@1|root,COG0601@2|Bacteria,2GBYF@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
SRR21617310_k127_437778_3	403833.Pmob_1783	1.642e-81	280.0	COG1173@1|root,COG1173@2|Bacteria,2GCC1@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
SRR21617310_k127_437778_2	391009.Tmel_1191	1.805e-100	336.0	COG0444@1|root,COG0444@2|Bacteria,2GC44@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SRR21617310_k127_437778_0	591019.Shell_0853	3.96e-121	398.0	COG4608@1|root,arCOG00184@2157|Archaea,2XQ0S@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	dppF	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
SRR21617310_k127_437778_5	224325.AF_1442	8.282e-09	57.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,245YC@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
SRR21617310_k127_452991_1	1047013.AQSP01000070_gene45	2.631e-66	235.0	COG1533@1|root,COG1533@2|Bacteria,2NPK6@2323|unclassified Bacteria	2|Bacteria	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
SRR21617310_k127_452991_2	1123008.KB905692_gene110	6.179e-28	125.0	COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,2FNX9@200643|Bacteroidia,22XHF@171551|Porphyromonadaceae	976|Bacteroidetes	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
SRR21617310_k127_452991_0	1104324.P186_0510	5.74e-151	490.0	COG1201@1|root,arCOG00557@2157|Archaea,2XPNI@28889|Crenarchaeota	28889|Crenarchaeota	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
SRR21617310_k127_462445_2	1343739.PAP_05870	3.391e-33	134.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
SRR21617310_k127_462445_1	573064.Mefer_0133	5.425e-34	142.0	COG4071@1|root,arCOG02715@2157|Archaea,2XUMN@28890|Euryarchaeota,23Q3S@183939|Methanococci	183939|Methanococci	H	F420-0:Gamma-glutamyl ligase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
SRR21617310_k127_462445_3	690850.Desaf_1827	0.0002508	50.0	COG1149@1|root,COG1149@2|Bacteria,1NCD9@1224|Proteobacteria,42PHV@68525|delta/epsilon subdivisions,2WKDZ@28221|Deltaproteobacteria,2M8KV@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
SRR21617310_k127_462445_4	391623.TERMP_00370	0.0007647	44.0	arCOG07495@1|root,arCOG07495@2157|Archaea,2Y1A6@28890|Euryarchaeota,244Q6@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
SRR21617310_k127_462445_0	593750.Metfor_1717	9.471e-143	461.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
SRR21617310_k127_465060_4	374847.Kcr_0136	2.184e-24	107.0	COG0838@1|root,arCOG01557@2157|Archaea	2157|Archaea	C	NADH ubiquinone oxidoreductase subunit 3 (Chain a)	nuoA	-	1.1.98.4,1.6.5.3	ko:K00330,ko:K22171	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
SRR21617310_k127_465060_2	374847.Kcr_0137	4.111e-72	249.0	COG0377@1|root,arCOG01554@2157|Archaea	2157|Archaea	C	Belongs to the complex I 20 kDa subunit family	nuoB	-	1.1.98.4,1.6.5.3	ko:K00331,ko:K00333,ko:K22172,ko:K22173	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Oxidored_q6
SRR21617310_k127_465060_3	374847.Kcr_0138	1.396e-34	138.0	COG0852@1|root,arCOG01551@2157|Archaea	2157|Archaea	C	NADH dehydrogenase (Ubiquinone), 30 kDa subunit	nuoC	-	1.1.98.4,1.5.98.3,1.6.5.3	ko:K00331,ko:K00332,ko:K13378,ko:K22160,ko:K22172	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Complex1_30kDa,Oxidored_q6
SRR21617310_k127_465060_0	374847.Kcr_0139	3.097e-180	571.0	COG0649@1|root,arCOG01548@2157|Archaea	2157|Archaea	C	COG0852 NADH ubiquinone oxidoreductase 27 kD subunit	nuoD	-	1.1.98.4,1.6.5.3	ko:K00333,ko:K13378,ko:K22172,ko:K22173	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
SRR21617310_k127_465060_1	374847.Kcr_0140	1.36e-105	352.0	COG1005@1|root,arCOG01546@2157|Archaea	2157|Archaea	C	NADH ubiquinone oxidoreductase subunit 1 (Chain H)	nuoH	-	1.1.98.4,1.6.5.3	ko:K00337,ko:K22175	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
SRR21617310_k127_474868_3	515635.Dtur_0011	9.327e-26	113.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
SRR21617310_k127_474868_1	386456.JQKN01000001_gene2000	1.121e-55	201.0	arCOG12324@1|root,arCOG12324@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_474868_4	243164.DET0017	3.871e-12	68.0	2BQDM@1|root,32J8W@2|Bacteria,2GB0B@200795|Chloroflexi,34DPG@301297|Dehalococcoidia	301297|Dehalococcoidia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_474868_5	158190.SpiGrapes_1470	3.071e-06	58.0	COG3393@1|root,COG3393@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_9,FR47
SRR21617310_k127_474868_0	1459636.NTE_01473	1.252e-109	362.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
SRR21617310_k127_474868_2	579137.Metvu_0224	1.643e-29	120.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23R03@183939|Methanococci	183939|Methanococci	J	Belongs to the SUI1 family	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
SRR21617310_k127_477098_0	1120999.JONM01000012_gene2242	1.643e-14	85.0	COG0823@1|root,COG0841@1|root,COG1361@1|root,COG1572@1|root,COG1657@1|root,COG2373@1|root,COG4733@1|root,COG0823@2|Bacteria,COG0841@2|Bacteria,COG1361@2|Bacteria,COG1572@2|Bacteria,COG1657@2|Bacteria,COG2373@2|Bacteria,COG4733@2|Bacteria,1QV7E@1224|Proteobacteria,2WHIN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM Outer membrane protein	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
SRR21617310_k127_477098_1	379066.GAU_3141	1.14e-13	83.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG3946@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,COG3946@2|Bacteria,1ZUIV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GM	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
SRR21617310_k127_477394_7	1220534.B655_2072	3.149e-36	145.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,23P1D@183925|Methanobacteria	183925|Methanobacteria	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
SRR21617310_k127_477394_6	105559.Nwat_0998	1.314e-38	148.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,1S9PQ@1236|Gammaproteobacteria,1X0ZT@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
SRR21617310_k127_477394_9	768679.TTX_1015	2.98e-15	83.0	arCOG06011@1|root,arCOG06011@2157|Archaea,2XR5I@28889|Crenarchaeota	28889|Crenarchaeota	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
SRR21617310_k127_477394_1	368408.Tpen_0773	3.603e-134	438.0	COG0126@1|root,arCOG00496@2157|Archaea,2XPWD@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
SRR21617310_k127_477394_0	123214.PERMA_0470	3.467e-138	447.0	COG0057@1|root,COG0057@2|Bacteria,2G3TK@200783|Aquificae	200783|Aquificae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
SRR21617310_k127_477394_3	444158.MmarC6_1414	1.137e-99	340.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,23Q75@183939|Methanococci	183939|Methanococci	P	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
SRR21617310_k127_477394_8	265729.GS18_0218105	1.325e-33	139.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,1ZGG0@1386|Bacillus	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
SRR21617310_k127_477394_4	1184251.TCELL_0084	4.937e-91	314.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
SRR21617310_k127_477394_2	399550.Smar_1225	1.554e-114	378.0	COG0470@1|root,arCOG00469@2157|Archaea,2XPQ0@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rep_fac_C,RuvB_N
SRR21617310_k127_477394_5	387631.Asulf_00584	1.205e-39	151.0	COG0069@1|root,arCOG00619@2157|Archaea,2XU89@28890|Euryarchaeota	28890|Euryarchaeota	E	Glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
SRR21617310_k127_486680_6	1041930.Mtc_0697	4.218e-34	133.0	COG0715@1|root,arCOG01803@2157|Archaea,2XWEK@28890|Euryarchaeota,2NAA1@224756|Methanomicrobia	224756|Methanomicrobia	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
SRR21617310_k127_486680_0	1041930.Mtc_1467	9.693e-96	327.0	COG4032@1|root,arCOG01614@2157|Archaea,2XVNH@28890|Euryarchaeota,2N9BM@224756|Methanomicrobia	224756|Methanomicrobia	G	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	comD/comE	-	4.1.1.79	ko:K13039	ko00680,ko01120,map00680,map01120	M00358	R05774	RC00506	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
SRR21617310_k127_486680_1	192952.MM_2355	6.652e-77	266.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,2N986@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
SRR21617310_k127_486680_10	999630.TUZN_1850	1.633e-12	70.0	COG0615@1|root,COG1849@1|root,arCOG01222@2157|Archaea,arCOG01224@2157|Archaea,2XQ8K@28889|Crenarchaeota	28889|Crenarchaeota	M	TIGRFAM cytidyltransferase-related domain	-	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,DUF357
SRR21617310_k127_486680_7	420247.Msm_0859	1.925e-32	132.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,23P3H@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
SRR21617310_k127_486680_2	1459636.NTE_01635	3.254e-50	186.0	COG1339@1|root,arCOG01904@2157|Archaea,41SG9@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Domain of unknown function DUF120	-	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase
SRR21617310_k127_486680_5	1006006.Mcup_0797	2.249e-35	137.0	COG1146@1|root,arCOG04548@2157|Archaea	2157|Archaea	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ferB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
SRR21617310_k127_486680_9	1459636.NTE_01195	6.028e-19	89.0	COG1522@1|root,arCOG01117@2157|Archaea	1459636.NTE_01195|-	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_486680_11	1297570.MESS4_260032	7.473e-09	65.0	COG2944@1|root,COG2944@2|Bacteria,1N97N@1224|Proteobacteria,2UJ0U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_486680_4	673860.AciM339_0348	1.082e-43	175.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y719@28890|Euryarchaeota,3F34W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRR21617310_k127_486680_3	1054217.TALC_00336	4.266e-45	174.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota	28890|Euryarchaeota	S	ICC-like phosphoesterases	rpe	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
SRR21617310_k127_486680_8	1131266.ARWQ01000008_gene334	8.606e-27	115.0	COG0483@1|root,arCOG01349@2157|Archaea,41SIF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
SRR21617310_k127_49411_8	368408.Tpen_0588	4.569e-14	72.0	COG0574@1|root,arCOG01111@2157|Archaea,2XPWQ@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
SRR21617310_k127_49411_4	579137.Metvu_0946	4.351e-49	181.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
SRR21617310_k127_49411_9	368408.Tpen_0140	2.203e-07	60.0	COG0717@1|root,arCOG04048@2157|Archaea,2XQDF@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
SRR21617310_k127_49411_7	1047013.AQSP01000144_gene918	2.303e-21	96.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
SRR21617310_k127_49411_6	521011.Mpal_1671	8.367e-39	147.0	COG2044@1|root,arCOG02066@2157|Archaea,2XWA5@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM DsrE family protein	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,TusA
SRR21617310_k127_49411_0	401526.TcarDRAFT_0036	2.66e-145	471.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,4H31K@909932|Negativicutes	909932|Negativicutes	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
SRR21617310_k127_49411_1	555079.Toce_1131	1.263e-60	211.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,42GNH@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
SRR21617310_k127_49411_5	339860.Msp_1545	6.906e-42	163.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,23P23@183925|Methanobacteria	183925|Methanobacteria	Q	Lysine methyltransferase	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
SRR21617310_k127_49411_2	269797.Mbar_A3234	3.246e-57	210.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
SRR21617310_k127_49411_3	186497.PF1862	3.099e-53	193.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,242KI@183968|Thermococci	183968|Thermococci	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
SRR21617310_k127_528199_1	1459636.NTE_03491	5.342e-11	68.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_528199_0	273116.14325522	1.19e-46	181.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRR21617310_k127_528946_5	1449049.JONW01000009_gene4363	2.031e-05	55.0	2E7B7@1|root,331UM@2|Bacteria,1N6KN@1224|Proteobacteria,2UD50@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_528946_4	693661.Arcve_1614	5.831e-80	280.0	COG0794@1|root,arCOG00068@2157|Archaea	693661.Arcve_1614|-	G	PFAM Sugar isomerase (SIS)	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_528946_1	368407.Memar_0659	4.725e-108	358.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N9HU@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
SRR21617310_k127_528946_2	1094980.Mpsy_1950	9.803e-90	303.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
SRR21617310_k127_528946_0	589924.Ferp_1191	3.265e-125	410.0	COG2141@1|root,arCOG02410@2157|Archaea,2XV6G@28890|Euryarchaeota,246P8@183980|Archaeoglobi	183980|Archaeoglobi	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
SRR21617310_k127_528946_3	706587.Desti_2250	7.345e-89	301.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
SRR21617310_k127_539266_0	158189.SpiBuddy_0682	5.985e-13	74.0	COG0716@1|root,COG0716@2|Bacteria,2JAHG@203691|Spirochaetes	203691|Spirochaetes	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_54147_3	1454007.JAUG01000055_gene3320	8.486e-06	56.0	COG1409@1|root,COG2911@1|root,COG1409@2|Bacteria,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Big_5,CHU_C,DUF642,Haemagg_act,SprB
SRR21617310_k127_54147_0	1198449.ACAM_0568	7.54e-226	711.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRM8@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
SRR21617310_k127_54147_1	517418.Ctha_2593	1.286e-68	243.0	COG0345@1|root,COG0345@2|Bacteria,1FE2A@1090|Chlorobi	1090|Chlorobi	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
SRR21617310_k127_54147_2	634498.mru_0898	9.582e-16	79.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,23NQV@183925|Methanobacteria	183925|Methanobacteria	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	-	ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
SRR21617310_k127_547386_1	868131.MSWAN_1368	5.321e-102	342.0	COG0438@1|root,arCOG01409@2157|Archaea,2XVDC@28890|Euryarchaeota,23NW3@183925|Methanobacteria	183925|Methanobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR21617310_k127_547386_5	1173026.Glo7428_0856	2.221e-12	76.0	COG0500@1|root,COG2226@2|Bacteria,1G3V3@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
SRR21617310_k127_547386_2	387631.Asulf_00032	5.178e-98	333.0	COG0297@1|root,arCOG01420@2157|Archaea,2Y8B5@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR21617310_k127_547386_4	926569.ANT_06370	9.531e-40	162.0	COG0438@1|root,COG0438@2|Bacteria,2G61I@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR21617310_k127_547386_0	1894.JOER01000017_gene4859	6.067e-103	347.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
SRR21617310_k127_547386_3	106370.Francci3_0224	1.536e-47	178.0	COG0451@1|root,COG0451@2|Bacteria,2GK8K@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SRR21617310_k127_565487_0	710696.Intca_3539	5.489e-24	111.0	COG2227@1|root,COG2227@2|Bacteria,2IIE2@201174|Actinobacteria,4FIIB@85021|Intrasporangiaceae	201174|Actinobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.11	ko:K03428	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R04237	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
SRR21617310_k127_565588_3	1163730.FFONT_0598	2.952e-41	156.0	COG0195@1|root,arCOG01760@2157|Archaea,2XQDA@28889|Crenarchaeota	28889|Crenarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
SRR21617310_k127_565588_0	368408.Tpen_1413	1.663e-224	712.0	COG2414@1|root,arCOG00709@2157|Archaea,2XRUI@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SRR21617310_k127_565588_2	368408.Tpen_1412	1.422e-62	219.0	COG1142@1|root,arCOG01502@2157|Archaea,2XR9N@28889|Crenarchaeota	28889|Crenarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_3,Fer4_4,Fer4_6,Fer4_9
SRR21617310_k127_565588_1	1459636.NTE_03323	2.942e-184	585.0	COG0143@1|root,arCOG00810@2157|Archaea,41SAF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
SRR21617310_k127_578181_6	656024.FsymDg_4186	1.225e-06	51.0	COG0451@1|root,COG0451@2|Bacteria,2GK8K@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SRR21617310_k127_578181_4	1382315.JPOI01000001_gene1139	2.924e-11	76.0	COG0438@1|root,COG0438@2|Bacteria,1UTQH@1239|Firmicutes,4HDWV@91061|Bacilli,1WFMC@129337|Geobacillus	91061|Bacilli	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
SRR21617310_k127_578181_0	368407.Memar_2057	7.868e-163	532.0	COG0367@1|root,arCOG00071@2157|Archaea,2XV5E@28890|Euryarchaeota,2N9BC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	asnB-1	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
SRR21617310_k127_578181_5	652103.Rpdx1_0684	1.21e-07	62.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,3JTA8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
SRR21617310_k127_578181_1	593117.TGAM_2155	3.35e-100	331.0	COG2120@1|root,arCOG03460@2157|Archaea,2XVSC@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
SRR21617310_k127_578181_2	1123371.ATXH01000018_gene1376	9.648e-74	255.0	COG1028@1|root,COG1028@2|Bacteria,2GH4K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
SRR21617310_k127_578181_3	360910.BAV0089	6.029e-29	133.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	2.3.1.157,2.3.1.79,2.7.7.23	ko:K00661,ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
SRR21617310_k127_578181_7	266117.Rxyl_0952	0.0001307	48.0	COG0500@1|root,COG2226@2|Bacteria,2HENT@201174|Actinobacteria,4CQIJ@84995|Rubrobacteria	84995|Rubrobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR21617310_k127_593732_1	572478.Vdis_1836	1.982e-42	162.0	COG0417@1|root,arCOG15272@2157|Archaea,2XPPT@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART DNA-directed DNA polymerase B	dpo1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
SRR21617310_k127_593732_0	1229909.NSED_05405	3.905e-199	642.0	COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA polymerase	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
SRR21617310_k127_593732_3	374847.Kcr_1174	3.897e-20	96.0	COG4708@1|root,arCOG07487@2157|Archaea	2157|Archaea	S	QueT transporter	-	-	-	-	-	-	-	-	-	-	-	-	QueT
SRR21617310_k127_593732_2	933801.Ahos_1172	8.72e-33	130.0	COG0008@1|root,arCOG00402@2157|Archaea,2XPVB@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
SRR21617310_k127_59675_1	374847.Kcr_1548	1.105e-145	468.0	COG1052@1|root,arCOG01755@2157|Archaea	2157|Archaea	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26,1.1.1.29	ko:K00015,ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
SRR21617310_k127_59675_0	1487923.DP73_14965	5.149e-158	507.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25ZZ5@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
SRR21617310_k127_59675_2	1041930.Mtc_2078	6.306e-16	82.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
SRR21617310_k127_617299_1	797299.HALLA_01165	1.79e-44	169.0	COG4430@1|root,arCOG10241@2157|Archaea,2XUJA@28890|Euryarchaeota,23U93@183963|Halobacteria	183963|Halobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SRR21617310_k127_617299_0	272844.PAB2112	1.403e-136	448.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
SRR21617310_k127_618455_2	387092.NIS_0181	1.281e-74	272.0	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42Q7W@68525|delta/epsilon subdivisions,2YQ1A@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Glycosyl transferase family 21	-	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Glyco_tranf_2_3
SRR21617310_k127_618455_0	410359.Pcal_1583	2.408e-96	325.0	COG0087@1|root,arCOG04070@2157|Archaea,2XPNG@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
SRR21617310_k127_618455_1	529709.PYCH_01380	6.619e-81	277.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,242NF@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
SRR21617310_k127_618455_3	573063.Metin_0580	4.904e-11	66.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,23R46@183939|Methanococci	183939|Methanococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
SRR21617310_k127_660478_5	868131.MSWAN_1817	2.069e-12	66.0	COG5485@1|root,arCOG06513@2157|Archaea,2Y3E5@28890|Euryarchaeota	28890|Euryarchaeota	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
SRR21617310_k127_660478_3	1459636.NTE_00882	2.589e-21	99.0	COG0426@1|root,arCOG00509@2157|Archaea	2157|Archaea	C	flavodoxin nitric oxide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
SRR21617310_k127_660478_2	500153.JOEK01000009_gene5062	5.168e-66	235.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
SRR21617310_k127_660478_4	1459636.NTE_02444	4.867e-20	100.0	arCOG01214@1|root,arCOG01214@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3,Trehalose_PPase
SRR21617310_k127_660478_0	572478.Vdis_0423	1.716e-129	435.0	arCOG05497@1|root,arCOG05497@2157|Archaea,2XPW7@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
SRR21617310_k127_660478_1	309799.DICTH_0189	1.387e-74	257.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
SRR21617310_k127_681321_7	246969.TAM4_1301	9.756e-10	65.0	COG4044@1|root,arCOG04612@2157|Archaea,2XT7E@28890|Euryarchaeota,242Y4@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein conserved in archaea (DUF2110)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2110
SRR21617310_k127_681321_3	243232.MJ_0778	1.98e-44	167.0	COG1418@1|root,arCOG01858@2157|Archaea,2XY7Y@28890|Euryarchaeota,23R1B@183939|Methanococci	183939|Methanococci	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
SRR21617310_k127_681321_4	436308.Nmar_1607	2.078e-43	164.0	COG1675@1|root,arCOG04270@2157|Archaea,41SJ8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
SRR21617310_k127_681321_2	765177.Desmu_1262	1.39e-53	194.0	COG1303@1|root,arCOG01857@2157|Archaea,2XQAA@28889|Crenarchaeota	28889|Crenarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
SRR21617310_k127_681321_1	1041930.Mtc_0091	1.563e-95	327.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,2N99S@224756|Methanomicrobia	224756|Methanomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
SRR21617310_k127_681321_6	1220534.B655_2136	3.927e-24	108.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,23PPT@183925|Methanobacteria	183925|Methanobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
SRR21617310_k127_681321_5	572546.Arcpr_0261	1.352e-38	151.0	COG1370@1|root,arCOG00991@2157|Archaea,2XYFT@28890|Euryarchaeota,2471G@183980|Archaeoglobi	183980|Archaeoglobi	O	PUA domain containing protein	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
SRR21617310_k127_681321_0	1365176.N186_01600	9.089e-117	384.0	COG1449@1|root,arCOG03278@2157|Archaea,2XQ1R@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
SRR21617310_k127_692194_3	69014.TK0533	4.994e-26	111.0	COG1594@1|root,arCOG00579@2157|Archaea,2XZ6S@28890|Euryarchaeota,245HK@183968|Thermococci	183968|Thermococci	K	RNA polymerase subunit 9	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
SRR21617310_k127_692194_0	877455.Metbo_0201	2.701e-49	183.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota	28890|Euryarchaeota	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
SRR21617310_k127_692194_4	1151117.AJLF01000001_gene1250	1.978e-21	98.0	arCOG05836@1|root,arCOG05836@2157|Archaea,2Y48U@28890|Euryarchaeota,2444T@183968|Thermococci	183968|Thermococci	S	Ribonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_2
SRR21617310_k127_692194_5	868131.MSWAN_2282	3.878e-16	81.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
SRR21617310_k127_692194_1	604354.TSIB_0492	2.06e-39	153.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,243T0@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
SRR21617310_k127_692194_2	868131.MSWAN_1473	1.836e-33	135.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,23PIV@183925|Methanobacteria	183925|Methanobacteria	Q	Ribosomal protein L11 methyltransferase (PrmA)	prmA	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
SRR21617310_k127_705904_3	1459636.NTE_01573	3.675e-09	61.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_705904_1	1220534.B655_0427	3.246e-73	254.0	COG1478@1|root,arCOG02714@2157|Archaea,2XTHI@28890|Euryarchaeota,23P1A@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
SRR21617310_k127_705904_0	604354.TSIB_1740	4.428e-138	449.0	COG0426@1|root,arCOG00509@2157|Archaea,2XSUD@28890|Euryarchaeota,243TG@183968|Thermococci	183968|Thermococci	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
SRR21617310_k127_705904_2	552811.Dehly_1481	4.03e-45	171.0	COG3945@1|root,COG3945@2|Bacteria	2|Bacteria	P	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
SRR21617310_k127_734534_0	273063.STK_03520	3.531e-69	244.0	COG0010@1|root,arCOG01700@2157|Archaea,2XQGD@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
SRR21617310_k127_734534_4	999630.TUZN_0848	4.266e-05	50.0	COG1694@1|root,arCOG01084@2157|Archaea	2157|Archaea	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG,MazG-like
SRR21617310_k127_734534_2	909663.KI867150_gene2301	8.635e-26	118.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
SRR21617310_k127_734534_1	663278.Ethha_0627	7.27e-27	127.0	COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,3WQ83@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SRR21617310_k127_734534_3	1245469.S58_28560	3.051e-21	109.0	COG0673@1|root,COG0673@2|Bacteria,1R8B2@1224|Proteobacteria,2VDKJ@28211|Alphaproteobacteria,3K3R9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
SRR21617310_k127_734534_5	999630.TUZN_0971	0.0001193	46.0	COG0303@1|root,arCOG00217@2157|Archaea,2XPP4@28889|Crenarchaeota	28889|Crenarchaeota	H	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
SRR21617310_k127_734733_0	264732.Moth_0405	6.285e-79	284.0	COG4986@1|root,COG4986@2|Bacteria,1TRRR@1239|Firmicutes,248X4@186801|Clostridia,42HSS@68295|Thermoanaerobacterales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
SRR21617310_k127_734733_1	309798.COPRO5265_0285	1.668e-77	266.0	COG1116@1|root,COG1116@2|Bacteria,1TT4F@1239|Firmicutes,24FTR@186801|Clostridia,42GE7@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
SRR21617310_k127_736349_2	694429.Pyrfu_0140	1.178e-17	86.0	COG2520@1|root,arCOG00033@2157|Archaea,2XPMY@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
SRR21617310_k127_736349_0	694429.Pyrfu_0799	1.693e-72	254.0	COG0478@1|root,arCOG01181@2157|Archaea,2XPM0@28889|Crenarchaeota	28889|Crenarchaeota	T	RIO-like serine threonine protein kinase fused to N-terminal HTH domain	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
SRR21617310_k127_736349_1	1041930.Mtc_0093	3.202e-42	168.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
SRR21617310_k127_736500_4	760568.Desku_2230	7.729e-64	227.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,266RE@186807|Peptococcaceae	186801|Clostridia	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
SRR21617310_k127_736500_1	580331.Thit_1131	4.097e-193	615.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,42EY5@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Conserved carboxylase region	pycB	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
SRR21617310_k127_736500_6	1151117.AJLF01000002_gene75	3.351e-18	92.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,245M9@183968|Thermococci	183968|Thermococci	C	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
SRR21617310_k127_736500_0	1304284.L21TH_0800	1.111e-241	758.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,36H9W@31979|Clostridiaceae	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
SRR21617310_k127_736500_2	309801.trd_A0613	8.309e-82	284.0	COG2309@1|root,COG2309@2|Bacteria,2G62B@200795|Chloroflexi,27YZB@189775|Thermomicrobia	189775|Thermomicrobia	E	Thermophilic metalloprotease (M29)	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
SRR21617310_k127_736500_5	1229909.NSED_09150	4.605e-57	211.0	COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota	651137|Thaumarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
SRR21617310_k127_736500_3	330779.Saci_0949	4.091e-80	274.0	COG1701@1|root,arCOG04262@2157|Archaea,2XPPD@28889|Crenarchaeota	28889|Crenarchaeota	S	Pantothenate synthetase	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
SRR21617310_k127_737643_2	2325.TKV_c08460	1.183e-39	170.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,42FS7@68295|Thermoanaerobacterales	186801|Clostridia	M	Serine protease with a broad substrate specificity	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
SRR21617310_k127_737643_3	673860.AciM339_1419	2.271e-19	103.0	arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG05978@2157|Archaea,2Y7X3@28890|Euryarchaeota,3F379@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
SRR21617310_k127_737643_1	1131266.ARWQ01000003_gene1571	4.173e-81	280.0	COG0451@1|root,arCOG01372@2157|Archaea	2157|Archaea	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
SRR21617310_k127_737643_0	453591.Igni_0623	2.404e-117	388.0	COG0381@1|root,arCOG01392@2157|Archaea,2XQ7Q@28889|Crenarchaeota	28889|Crenarchaeota	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
SRR21617310_k127_739856_0	399550.Smar_0907	5.417e-207	657.0	COG0459@1|root,arCOG01257@2157|Archaea,2XPYR@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM chaperonin Cpn60 TCP-1	thsB	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
SRR21617310_k127_749388_2	1197130.BAFM01000011_gene2073	3.461e-14	81.0	COG1714@1|root,arCOG03633@2157|Archaea,2XYB1@28890|Euryarchaeota,23WIB@183963|Halobacteria	183963|Halobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
SRR21617310_k127_749388_1	323259.Mhun_2873	3.338e-24	116.0	COG0477@1|root,arCOG00130@2157|Archaea,2XTI7@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
SRR21617310_k127_749388_0	1343739.PAP_08035	3.67e-38	154.0	COG0730@1|root,arCOG02050@2157|Archaea,2XSTS@28890|Euryarchaeota,243BP@183968|Thermococci	183968|Thermococci	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
SRR21617310_k127_764916_1	342949.PNA2_0057	9.488e-32	128.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
SRR21617310_k127_764916_0	1459636.NTE_00653	2.436e-47	180.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
SRR21617310_k127_764916_2	1184251.TCELL_0428	1.504e-12	68.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
SRR21617310_k127_769569_0	387631.Asulf_00584	5.776e-193	611.0	COG0069@1|root,arCOG00619@2157|Archaea,2XU89@28890|Euryarchaeota	28890|Euryarchaeota	E	Glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
SRR21617310_k127_769569_6	1123276.KB893270_gene4732	3.385e-18	93.0	COG0671@1|root,COG0671@2|Bacteria,4NI23@976|Bacteroidetes,47QSU@768503|Cytophagia	976|Bacteroidetes	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
SRR21617310_k127_769569_4	765177.Desmu_0469	1.114e-25	117.0	COG2245@1|root,arCOG01644@2157|Archaea,2XRHI@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF996)	-	-	-	-	-	-	-	-	-	-	-	-	DUF996
SRR21617310_k127_769569_5	317936.Nos7107_5343	3.346e-22	100.0	COG5485@1|root,COG5485@2|Bacteria,1G6B9@1117|Cyanobacteria,1HTUC@1161|Nostocales	1117|Cyanobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
SRR21617310_k127_769569_8	1349820.M707_09050	5.33e-08	61.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_3,Flavodoxin_5
SRR21617310_k127_769569_9	1343739.PAP_03055	2.249e-07	59.0	COG1522@1|root,arCOG01581@2157|Archaea,2Y3C6@28890|Euryarchaeota,2442S@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
SRR21617310_k127_769569_1	1121423.JONT01000005_gene2608	7.428e-118	388.0	COG0384@1|root,COG0384@2|Bacteria,1TPPX@1239|Firmicutes,247ZD@186801|Clostridia	186801|Clostridia	S	Phenazine biosynthesis protein, PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
SRR21617310_k127_769569_11	1280688.AUJB01000009_gene1660	0.0003365	45.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia,3NHKF@46205|Pseudobutyrivibrio	186801|Clostridia	S	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,zinc_ribbon_2
SRR21617310_k127_769569_7	702450.CUW_2600	3.687e-14	78.0	COG0295@1|root,COG0295@2|Bacteria,1UW91@1239|Firmicutes,3VU2X@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
SRR21617310_k127_769569_3	1220534.B655_0836	1.394e-42	165.0	COG4430@1|root,arCOG10241@2157|Archaea,2XUJA@28890|Euryarchaeota,23PV8@183925|Methanobacteria	183925|Methanobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
SRR21617310_k127_769569_2	570952.ATVH01000017_gene1630	2.786e-86	298.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2TRCB@28211|Alphaproteobacteria,2JPJQ@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
SRR21617310_k127_771946_2	498211.CJA_3428	3.081e-05	55.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,1RREJ@1236|Gammaproteobacteria,1FFYS@10|Cellvibrio	1236|Gammaproteobacteria	G	Domain of unknown function (DUF3473)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
SRR21617310_k127_771946_0	387092.NIS_0181	1.396e-26	123.0	COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,42Q7W@68525|delta/epsilon subdivisions,2YQ1A@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Glycosyl transferase family 21	-	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Glyco_tranf_2_3
SRR21617310_k127_771946_1	521011.Mpal_0351	3.407e-15	78.0	COG2006@1|root,arCOG02447@2157|Archaea,2XWUP@28890|Euryarchaeota,2NB6D@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
SRR21617310_k127_800301_0	697281.Mahau_1925	5.759e-05	54.0	COG1975@1|root,COG3209@1|root,COG1975@2|Bacteria,COG3209@2|Bacteria,1V8N1@1239|Firmicutes,24KAW@186801|Clostridia,42GJS@68295|Thermoanaerobacterales	186801|Clostridia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	TGFb_propeptide
SRR21617310_k127_837729_0	335543.Sfum_3688	5.516e-100	338.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42YGX@68525|delta/epsilon subdivisions,2WTHT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
SRR21617310_k127_837729_3	867845.KI911784_gene292	1.962e-21	103.0	COG0500@1|root,COG2226@2|Bacteria,2G948@200795|Chloroflexi,376TJ@32061|Chloroflexia	32061|Chloroflexia	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
SRR21617310_k127_837729_1	579137.Metvu_0521	1.526e-62	220.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,23PZR@183939|Methanococci	183939|Methanococci	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
SRR21617310_k127_837729_2	573064.Mefer_1275	8.941e-51	184.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,23Q6M@183939|Methanococci	183939|Methanococci	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
SRR21617310_k127_842240_0	1449126.JQKL01000016_gene2854	2.184e-142	473.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
SRR21617310_k127_843431_2	633148.Tagg_0182	2.083e-100	342.0	COG1163@1|root,arCOG00358@2157|Archaea,2XPR5@28889|Crenarchaeota	28889|Crenarchaeota	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
SRR21617310_k127_843431_1	760568.Desku_2160	8.612e-101	334.0	COG0123@1|root,COG0123@2|Bacteria,1V066@1239|Firmicutes,2483W@186801|Clostridia,264JJ@186807|Peptococcaceae	186801|Clostridia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
SRR21617310_k127_843431_0	1343739.PAP_10275	5.708e-114	377.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
SRR21617310_k127_851742_0	1499967.BAYZ01000009_gene5268	1.528e-44	169.0	COG2220@1|root,COG2220@2|Bacteria,2NPQC@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
SRR21617310_k127_851956_5	671065.MetMK1DRAFT_00011920	1.21e-21	98.0	COG1053@1|root,arCOG00571@2157|Archaea,2XPP3@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
SRR21617310_k127_851956_0	868131.MSWAN_1693	1.284e-123	416.0	COG0247@1|root,COG0479@1|root,arCOG00333@2157|Archaea,arCOG00963@2157|Archaea,2Y85M@28890|Euryarchaeota,23NVI@183925|Methanobacteria	183925|Methanobacteria	C	fumarate reductase	-	-	1.3.4.1	ko:K18210	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00620	R10660	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,Fer2_3,Fer4_8
SRR21617310_k127_851956_4	374847.Kcr_1294	1.385e-22	113.0	COG0308@1|root,arCOG02969@2157|Archaea	2157|Archaea	E	Peptidase M1 membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
SRR21617310_k127_851956_1	420247.Msm_1031	3.124e-86	300.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
SRR21617310_k127_851956_2	868131.MSWAN_0387	4.335e-39	152.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota	28890|Euryarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
SRR21617310_k127_851956_3	192952.MM_2814	4.645e-25	109.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,2N9PE@224756|Methanomicrobia	224756|Methanomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
SRR21617310_k127_85863_0	387631.Asulf_00331	6.163e-63	229.0	COG1908@1|root,arCOG02476@2157|Archaea,2Y7JQ@28890|Euryarchaeota,247HT@183980|Archaeoglobi	183980|Archaeoglobi	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
SRR21617310_k127_859689_6	59689.fgenesh2_kg.3__2446__AT3G22320.1	5.65e-22	102.0	COG2012@1|root,KOG3218@2759|Eukaryota,37R44@33090|Viridiplantae,3GB94@35493|Streptophyta,3HU40@3699|Brassicales	35493|Streptophyta	K	DNA-directed RNA polymerases II and IV subunit 5A	-	GO:0000418,GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005730,GO:0005736,GO:0006139,GO:0006351,GO:0006366,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016591,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044452,GO:0044464,GO:0046483,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	-	ko:K03013	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb5_C,RNA_pol_Rpb5_N
SRR21617310_k127_859689_7	1459636.NTE_03491	3.125e-13	73.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_859689_9	671065.MetMK1DRAFT_00024240	5.876e-05	55.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
SRR21617310_k127_859689_4	679926.Mpet_1015	7.971e-34	145.0	COG1208@1|root,arCOG00664@2157|Archaea,2Y87H@28890|Euryarchaeota,2NBGU@224756|Methanomicrobia	224756|Methanomicrobia	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
SRR21617310_k127_859689_0	246969.TAM4_218	1.367e-124	412.0	COG1004@1|root,arCOG00253@2157|Archaea,2XTQY@28890|Euryarchaeota,242NM@183968|Thermococci	183968|Thermococci	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
SRR21617310_k127_859689_1	186497.PF1357	5.819e-111	369.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,243ND@183968|Thermococci	28890|Euryarchaeota	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
SRR21617310_k127_859689_2	1123508.JH636445_gene6704	4.683e-49	183.0	COG1216@1|root,COG1216@2|Bacteria,2J55Z@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
SRR21617310_k127_859689_5	1324957.K933_16617	2.937e-25	119.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUVC@28890|Euryarchaeota,2418N@183963|Halobacteria	183963|Halobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR21617310_k127_859689_3	579137.Metvu_0783	4.758e-39	162.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,23Q2P@183939|Methanococci	183939|Methanococci	M	PFAM Glycosyl transferase, group 1	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
SRR21617310_k127_859689_8	1254432.SCE1572_45215	2.99e-05	48.0	COG0463@1|root,COG1541@1|root,COG0463@2|Bacteria,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WMGG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	coenzyme F390	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,Glycos_transf_2
SRR21617310_k127_862447_3	1487923.DP73_08235	5.035e-43	167.0	COG5598@1|root,COG5598@2|Bacteria,1V0ZE@1239|Firmicutes,24D6Y@186801|Clostridia,266YG@186807|Peptococcaceae	186801|Clostridia	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
SRR21617310_k127_862447_2	1340434.AXVA01000008_gene3673	8.231e-69	247.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HEZ6@91061|Bacilli,1ZB1Z@1386|Bacillus	91061|Bacilli	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
SRR21617310_k127_862447_0	309801.trd_A0362	8.35e-158	508.0	COG0160@1|root,COG0160@2|Bacteria,2G7XB@200795|Chloroflexi,27Z3E@189775|Thermomicrobia	189775|Thermomicrobia	E	Aminotransferase class-III	-	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
SRR21617310_k127_862447_1	1121430.JMLG01000002_gene1106	6.567e-132	434.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248QX@186801|Clostridia,260AJ@186807|Peptococcaceae	186801|Clostridia	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
SRR21617310_k127_868410_3	693661.Arcve_1454	1.461e-10	64.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,2465E@183980|Archaeoglobi	183980|Archaeoglobi	S	amino acid-binding ACT domain protein	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	ACT
SRR21617310_k127_868410_0	186497.PF1592	1.162e-175	562.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,2438I@183968|Thermococci	183968|Thermococci	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
SRR21617310_k127_868410_2	593117.TGAM_1854	1.146e-69	244.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,242TE@183968|Thermococci	183968|Thermococci	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
SRR21617310_k127_868410_1	330779.Saci_0986	7.57e-89	305.0	COG0644@1|root,arCOG00570@2157|Archaea,2XPWV@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,Trp_halogenase
SRR21617310_k127_887639_1	694429.Pyrfu_0129	1.612e-45	171.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
SRR21617310_k127_887639_0	523845.AQXV01000053_gene658	1.577e-47	176.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,23QV3@183939|Methanococci	183939|Methanococci	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
SRR21617310_k127_887639_2	694429.Pyrfu_0044	7.85e-29	120.0	COG1931@1|root,arCOG01043@2157|Archaea,2XQU6@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
SRR21617310_k127_887639_3	573063.Metin_1052	3.325e-28	123.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,23QS3@183939|Methanococci	183939|Methanococci	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
SRR21617310_k127_887639_4	1382306.JNIM01000001_gene3984	8.894e-18	88.0	COG1695@1|root,COG1695@2|Bacteria,2G974@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
SRR21617310_k127_891858_0	573064.Mefer_1535	3.246e-113	374.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,23Q6K@183939|Methanococci	183939|Methanococci	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
SRR21617310_k127_891858_1	644281.MFS40622_0057	3.783e-95	327.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,23RGY@183939|Methanococci	183939|Methanococci	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one- carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
SRR21617310_k127_900304_1	419665.Maeo_0661	8.523e-16	82.0	COG1658@1|root,arCOG01486@2157|Archaea,2XYTB@28890|Euryarchaeota,23R5F@183939|Methanococci	183939|Methanococci	L	SMART Toprim sub domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_4
SRR21617310_k127_900304_0	186497.PF1725	2.343e-108	362.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
SRR21617310_k127_900304_2	1457250.BBMO01000002_gene2414	0.0001725	52.0	COG1378@1|root,arCOG02038@2157|Archaea,2XUX7@28890|Euryarchaeota,23TDG@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
SRR21617310_k127_909793_0	368408.Tpen_0341	7.941e-169	536.0	COG1156@1|root,arCOG00865@2157|Archaea,2XPKW@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
SRR21617310_k127_909793_1	374847.Kcr_1302	1.519e-26	117.0	COG1394@1|root,arCOG04101@2157|Archaea	2157|Archaea	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0384	ATP-synt_D
SRR21617310_k127_909793_3	357809.Cphy_3447	1.017e-07	63.0	COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia,21XTE@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
SRR21617310_k127_909793_2	374847.Kcr_1304	2.726e-11	66.0	COG0636@1|root,arCOG02455@2157|Archaea	2157|Archaea	C	H transporting two-sector ATPase C subunit	atpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0390	ATP-synt_C
SRR21617310_k127_94149_2	1198449.ACAM_1383	8.943e-101	334.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
SRR21617310_k127_94149_1	694429.Pyrfu_0958	3.759e-131	435.0	COG0252@1|root,arCOG01924@2157|Archaea,2XPTP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
SRR21617310_k127_94149_0	391623.TERMP_01713	1.584e-171	553.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,2430Z@183968|Thermococci	183968|Thermococci	K	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
SRR21617310_k127_94149_3	868131.MSWAN_1467	2.166e-42	159.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,23P04@183925|Methanobacteria	183925|Methanobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
SRR21617310_k127_951063_3	457570.Nther_2770	1.51e-14	81.0	2ACGP@1|root,3122D@2|Bacteria,1V5NE@1239|Firmicutes,24J4I@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SRR21617310_k127_951063_0	579137.Metvu_1361	3.359e-79	275.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,23Q6B@183939|Methanococci	183939|Methanococci	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
SRR21617310_k127_951063_1	1094980.Mpsy_2759	5.739e-59	214.0	COG2218@1|root,arCOG00097@2157|Archaea,2XW26@28890|Euryarchaeota,2NBJQ@224756|Methanomicrobia	224756|Methanomicrobia	C	GXGXG motif	fmdC	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
SRR21617310_k127_951063_2	224325.AF_1930	4.234e-30	124.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,245US@183980|Archaeoglobi	183980|Archaeoglobi	C	Formylmethanofuran dehydrogenase subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
SRR21617310_k127_957749_3	351160.LRC458	6.455e-10	60.0	COG1880@1|root,arCOG04408@2157|Archaea,2XWPE@28890|Euryarchaeota,2NA4Z@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear	cdhB	-	-	ko:K00195	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002	-	-	-	CO_dh
SRR21617310_k127_957749_2	593750.Metfor_1720	9.152e-35	136.0	COG1880@1|root,arCOG04408@2157|Archaea,2XWPE@28890|Euryarchaeota,2NA4Z@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear	cdhB	-	-	ko:K00195	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002	-	-	-	CO_dh
SRR21617310_k127_957749_0	593750.Metfor_1719	1.706e-191	608.0	COG1614@1|root,arCOG04360@2157|Archaea,2XU0D@28890|Euryarchaeota,2N95I@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex)	cdhC	-	-	ko:K00193	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00357,M00422	R09096,R10219	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
SRR21617310_k127_957749_1	323259.Mhun_0687	6.276e-53	194.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,2N93F@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0200	CdhD
SRR21617310_k127_97160_1	453591.Igni_0915	7.866e-23	103.0	COG1051@1|root,arCOG01075@2157|Archaea,2XR8E@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM NUDIX hydrolase	-	-	3.6.1.13,3.6.1.55	ko:K01515,ko:K03574	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
SRR21617310_k127_97160_0	439481.Aboo_0814	6.627e-34	134.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,3F2GX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
## 1144 queries scanned
## Total time (seconds): 3.7002720832824707
## Rate: 309.17 q/s