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Overview

ID MAG01616
Name HFD1_bin.24
Sample SMP0043
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Sphingomonadales
Family Sphingomonadaceae
Genus Sphingomicrobium
Species
Assembly information
Completeness (%) 83.1
Contamination (%) 2.29
GC content (%) 64.0
N50 (bp) 9,389
Genome size (bp) 1,799,562

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1908

Gene name Description KEGG GOs EC E-value Score Sequence
HFD1_k127_1010824_0 Deoxyribodipyrimidine photo-lyase-related protein K06876 - - 3.079e-214 687.0
HFD1_k127_1010824_1 Histidine kinase K02480 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 382.0
HFD1_k127_1010824_2 helix_turn_helix, Lux Regulon K07684 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002673 271.0
HFD1_k127_1010824_3 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000019 222.0
HFD1_k127_1010824_4 SOUL heme-binding protein - - - 0.000000000000000000000000000000000000000000000000000001461 199.0
HFD1_k127_1010824_5 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000000000000000000000000000000002059 195.0
HFD1_k127_1010824_6 Transposase - - - 0.000000000000000000000004493 104.0
HFD1_k127_1010824_7 Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers K06955 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050664,GO:0051287,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 - 0.00000000001735 71.0
HFD1_k127_1010824_8 NmrA-like family - - - 0.00000006228 54.0
HFD1_k127_1010824_9 Domain of unknown function (DUF309) K09763 - - 0.00001018 53.0
HFD1_k127_1028983_0 E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate K00164 - 1.2.4.2 2.035e-203 638.0
HFD1_k127_1028983_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 302.0
HFD1_k127_1031884_0 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes K00639,K00652 - 2.3.1.29,2.3.1.47 1.228e-227 709.0
HFD1_k127_1031884_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 600.0
HFD1_k127_1031884_2 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 511.0
HFD1_k127_1031884_3 asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 366.0
HFD1_k127_1031884_4 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 351.0
HFD1_k127_1031884_5 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008037 249.0
HFD1_k127_1031884_6 - - - - 0.000000000000000000000000000000000000000000000000000000000001482 217.0
HFD1_k127_1031884_7 acyl carrier protein - - - 0.000000000000000000000000000000007512 131.0
HFD1_k127_1052503_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.571e-257 806.0
HFD1_k127_1052503_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 315.0
HFD1_k127_1052503_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000002928 252.0
HFD1_k127_1063341_0 DNA helicase K03657 - 3.6.4.12 0.0 1227.0
HFD1_k127_1063341_1 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1159.0
HFD1_k127_1063341_10 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 447.0
HFD1_k127_1063341_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 447.0
HFD1_k127_1063341_12 protein conserved in bacteria K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 443.0
HFD1_k127_1063341_13 Terminase RNaseH-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009406 437.0
HFD1_k127_1063341_14 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 415.0
HFD1_k127_1063341_15 protein conserved in bacteria K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 389.0
HFD1_k127_1063341_16 serine acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 357.0
HFD1_k127_1063341_17 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005002 356.0
HFD1_k127_1063341_18 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 301.0
HFD1_k127_1063341_19 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 301.0
HFD1_k127_1063341_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 4.43e-317 977.0
HFD1_k127_1063341_20 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 288.0
HFD1_k127_1063341_21 PFAM inositol monophosphatase K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006174 295.0
HFD1_k127_1063341_22 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002437 279.0
HFD1_k127_1063341_23 protein conserved in bacteria K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007092 253.0
HFD1_k127_1063341_24 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001185 242.0
HFD1_k127_1063341_25 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002152 224.0
HFD1_k127_1063341_26 Methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000000000000353 201.0
HFD1_k127_1063341_27 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000002494 176.0
HFD1_k127_1063341_28 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000001308 155.0
HFD1_k127_1063341_29 response regulator - - - 0.00000000000000000000000000000000001836 142.0
HFD1_k127_1063341_3 Acetyl-coenzyme A transporter 1 K08218 - - 1.283e-221 701.0
HFD1_k127_1063341_30 Protein of unknown function (DUF2794) - - - 0.00000000000000000000000008463 111.0
HFD1_k127_1063341_31 Pfam:DUF1049 K08992 - - 0.000000000000000000000002894 109.0
HFD1_k127_1063341_32 PFAM blue (type 1) copper domain protein - - - 0.0000000000000001772 84.0
HFD1_k127_1063341_33 - - - - 0.000000000000001112 85.0
HFD1_k127_1063341_34 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000003191 76.0
HFD1_k127_1063341_35 Protein of unknown function (DUF2793) - - - 0.000000000007794 71.0
HFD1_k127_1063341_36 PilZ domain - - - 0.00000001642 64.0
HFD1_k127_1063341_4 beta-lactamase K01467 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 559.0
HFD1_k127_1063341_5 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008872 554.0
HFD1_k127_1063341_6 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004386 535.0
HFD1_k127_1063341_7 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 499.0
HFD1_k127_1063341_8 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 491.0
HFD1_k127_1063341_9 Transcriptional regulator K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 454.0
HFD1_k127_113744_0 Metal-dependent hydrolase - - - 3.349e-194 619.0
HFD1_k127_113744_1 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 567.0
HFD1_k127_113744_2 Thiol disulfide interchange protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 458.0
HFD1_k127_113744_3 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 407.0
HFD1_k127_1145502_0 amino acid peptide transporter K03305 - - 3.808e-253 790.0
HFD1_k127_1145502_1 amidohydrolase - - - 6.105e-230 722.0
HFD1_k127_1145502_2 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 434.0
HFD1_k127_1183316_0 Belongs to the AAA ATPase family K13525 - - 0.0 1270.0
HFD1_k127_1183316_1 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 461.0
HFD1_k127_1183316_2 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 303.0
HFD1_k127_1183316_3 KR domain K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008419 286.0
HFD1_k127_1183316_4 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000001677 190.0
HFD1_k127_1235348_0 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain K12541 - - 1.97e-234 736.0
HFD1_k127_1235348_1 Outer membrane efflux protein K12543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 477.0
HFD1_k127_1262803_0 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005199 289.0
HFD1_k127_1262803_1 Short-chain dehydrogenase reductase SDR K21883 - 1.1.1.401 0.0000000000000000000000000000000000000000000000000000000000001594 217.0
HFD1_k127_1284635_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1277.0
HFD1_k127_1284635_1 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 2.136e-227 717.0
HFD1_k127_1358202_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 5.523e-200 630.0
HFD1_k127_1358202_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007395 307.0
HFD1_k127_1358202_2 Protein required for attachment to host cells - - - 0.000000000000000000000000000000000000000000000000005722 183.0
HFD1_k127_1421131_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 7.054e-243 753.0
HFD1_k127_1421131_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 6.489e-231 721.0
HFD1_k127_1421131_10 ErfK ybiS ycfS ynhG family protein - - - 0.00000000000000000000000000000000000000000000000000000002493 206.0
HFD1_k127_1421131_11 - - - - 0.0000000000000000003722 95.0
HFD1_k127_1421131_12 NlpC/P60 family - - - 0.00000000000000005967 87.0
HFD1_k127_1421131_13 - K06078 - - 0.00000000000003936 75.0
HFD1_k127_1421131_14 PA domain - - - 0.000000000001033 78.0
HFD1_k127_1421131_2 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 611.0
HFD1_k127_1421131_3 Sugar (and other) transporter K03762 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 597.0
HFD1_k127_1421131_4 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006058 569.0
HFD1_k127_1421131_5 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008847 558.0
HFD1_k127_1421131_6 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 394.0
HFD1_k127_1421131_7 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000031 278.0
HFD1_k127_1421131_8 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005549 263.0
HFD1_k127_1421131_9 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000001386 206.0
HFD1_k127_145433_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1407.0
HFD1_k127_1550563_0 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000000000003416 166.0
HFD1_k127_1550563_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000002065 155.0
HFD1_k127_1550563_10 'Cold-shock' DNA-binding domain K03704 - - 0.00007865 48.0
HFD1_k127_1550563_11 Protein of unknown function (DUF3606) - - - 0.0000898 51.0
HFD1_k127_1550563_4 rhamnose metabolic process - - - 0.0000000000000000003326 90.0
HFD1_k127_1550563_6 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000005831 69.0
HFD1_k127_1550563_9 Antibiotic biosynthesis monooxygenase - - - 0.00001355 48.0
HFD1_k127_1604801_0 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000587 462.0
HFD1_k127_1604801_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001899 278.0
HFD1_k127_1604801_2 signal peptide peptidase K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000002197 232.0
HFD1_k127_1604801_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000000001564 177.0
HFD1_k127_161371_0 Ring hydroxylating alpha subunit (catalytic domain) - - - 2.063e-200 631.0
HFD1_k127_161371_1 Binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003539 261.0
HFD1_k127_161371_2 XRE family transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000865 255.0
HFD1_k127_161371_3 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000005713 252.0
HFD1_k127_161371_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000538 233.0
HFD1_k127_161371_5 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000000000000000221 205.0
HFD1_k127_161371_6 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000000000000000000000000000000000000002444 201.0
HFD1_k127_161371_7 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000006411 213.0
HFD1_k127_161371_8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000000000000000003202 140.0
HFD1_k127_161371_9 amino acid - - - 0.000000000001239 70.0
HFD1_k127_1613870_0 Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA K00253 - 1.3.8.4 2.806e-214 670.0
HFD1_k127_1613870_1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 571.0
HFD1_k127_1613870_2 Peptidase family M13 K07386 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 308.0
HFD1_k127_1613870_3 Endoribonuclease L-PSP - - - 0.000000000000000000005169 93.0
HFD1_k127_1676720_0 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 440.0
HFD1_k127_1676720_1 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 358.0
HFD1_k127_1676720_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 354.0
HFD1_k127_1676720_3 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 314.0
HFD1_k127_1676720_4 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000001923 199.0
HFD1_k127_1676720_5 adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000001387 132.0
HFD1_k127_1676720_6 cheY-homologous receiver domain - - - 0.000000000000000000000007615 108.0
HFD1_k127_1676720_7 - - - - 0.0000000000000000006543 89.0
HFD1_k127_168758_0 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006946 463.0
HFD1_k127_168758_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 448.0
HFD1_k127_168758_2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.0000000000000000000000000000000000000000000000000000000000001179 216.0
HFD1_k127_168758_3 import inner membrane translocase, subunit Tim44 - - - 0.00000000000006155 73.0
HFD1_k127_1736883_0 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 588.0
HFD1_k127_1736883_1 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.000000000000000000000000000000000000000000364 159.0
HFD1_k127_1736883_2 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related - - - 0.000000000000000000000008865 102.0
HFD1_k127_1745141_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0 1195.0
HFD1_k127_1745141_1 Peptidase, M16 - - - 0.0 1144.0
HFD1_k127_1745141_10 Response regulator of the LytR AlgR family K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005672 466.0
HFD1_k127_1745141_11 ABC transporter, ATP-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008109 468.0
HFD1_k127_1745141_12 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 462.0
HFD1_k127_1745141_13 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 455.0
HFD1_k127_1745141_14 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 455.0
HFD1_k127_1745141_15 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 425.0
HFD1_k127_1745141_16 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003875 372.0
HFD1_k127_1745141_17 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 369.0
HFD1_k127_1745141_18 Binding-protein-dependent transport system inner membrane component K02038 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005604 361.0
HFD1_k127_1745141_19 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000639 356.0
HFD1_k127_1745141_2 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1046.0
HFD1_k127_1745141_20 ABC-type Na efflux pump, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 346.0
HFD1_k127_1745141_21 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007875 329.0
HFD1_k127_1745141_22 PFAM CheB methylesterase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 332.0
HFD1_k127_1745141_23 protein involved in formation of curli polymers - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 324.0
HFD1_k127_1745141_24 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 326.0
HFD1_k127_1745141_25 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 296.0
HFD1_k127_1745141_26 COG2513 PEP phosphonomutase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005535 282.0
HFD1_k127_1745141_27 COG2513 PEP phosphonomutase and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002382 280.0
HFD1_k127_1745141_28 Protein of unknown function (DUF2490) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006121 276.0
HFD1_k127_1745141_29 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000001541 246.0
HFD1_k127_1745141_3 Histidine kinase - - - 1.515e-239 762.0
HFD1_k127_1745141_30 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006169 251.0
HFD1_k127_1745141_31 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001645 250.0
HFD1_k127_1745141_32 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000001846 206.0
HFD1_k127_1745141_33 Carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000109 192.0
HFD1_k127_1745141_34 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000002144 172.0
HFD1_k127_1745141_35 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000006957 171.0
HFD1_k127_1745141_36 EthD domain - - - 0.000000000000000000000000000000000000002319 148.0
HFD1_k127_1745141_37 Response regulator, receiver - - - 0.00000000000000000000005705 103.0
HFD1_k127_1745141_39 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000000001933 79.0
HFD1_k127_1745141_4 Carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 565.0
HFD1_k127_1745141_40 Response regulator receiver - - - 0.0000000003752 66.0
HFD1_k127_1745141_5 Cysteine synthase K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 554.0
HFD1_k127_1745141_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 541.0
HFD1_k127_1745141_7 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 530.0
HFD1_k127_1745141_8 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 480.0
HFD1_k127_1745141_9 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 471.0
HFD1_k127_1767830_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 1.809e-239 745.0
HFD1_k127_1767830_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 3.556e-196 619.0
HFD1_k127_1767830_2 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 366.0
HFD1_k127_1767830_3 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001876 242.0
HFD1_k127_1767830_4 AraC-like ligand binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002081 251.0
HFD1_k127_1767830_5 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000000003755 212.0
HFD1_k127_1767830_6 Domain of unknown function (DUF4386) - - - 0.0000000000000015 85.0
HFD1_k127_1767830_7 DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - 0.0003847 46.0
HFD1_k127_1786762_0 helicase K03724 - - 0.0 1215.0
HFD1_k127_1786762_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 1.449e-297 916.0
HFD1_k127_1786762_2 phosphomannomutase K01840 - 5.4.2.8 1.743e-206 647.0
HFD1_k127_1786762_3 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 540.0
HFD1_k127_1786762_4 transcriptional - - - 0.000000000000000000000000000000000000000000000001218 179.0
HFD1_k127_1786762_5 - - - - 0.0000000000000000000000000000000000000000000004939 170.0
HFD1_k127_1786762_6 - - - - 0.000000000000000005993 87.0
HFD1_k127_1786762_7 - - - - 0.000000002209 62.0
HFD1_k127_1828764_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 6.825e-316 976.0
HFD1_k127_1828764_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 601.0
HFD1_k127_1828764_10 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.00000000000000000000000000000000000000000005164 168.0
HFD1_k127_1828764_11 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000001771 49.0
HFD1_k127_1828764_2 MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 370.0
HFD1_k127_1828764_3 Polynucleotide adenylyltransferase K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 322.0
HFD1_k127_1828764_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001402 275.0
HFD1_k127_1828764_5 protein conserved in bacteria K09986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002202 262.0
HFD1_k127_1828764_6 Nudix hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001039 238.0
HFD1_k127_1828764_7 Biopolymer transport protein K03559 - - 0.00000000000000000000000000000000000000000000000000000000003921 207.0
HFD1_k127_1828764_8 Biopolymer K03559 - - 0.0000000000000000000000000000000000000000000000000000008359 196.0
HFD1_k127_1828764_9 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.00000000000000000000000000000000000000000000001014 181.0
HFD1_k127_1840750_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1026.0
HFD1_k127_1840750_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.372e-208 666.0
HFD1_k127_1840750_2 Pyridoxal-phosphate dependent enzyme K01751 - 4.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 327.0
HFD1_k127_1840750_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 304.0
HFD1_k127_1840750_4 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000002676 223.0
HFD1_k127_1840750_5 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000001787 169.0
HFD1_k127_1840750_6 Transcriptional regulator K07729 - - 0.000000000000000000000001685 104.0
HFD1_k127_1846564_0 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004356 327.0
HFD1_k127_1846564_1 Membrane - - - 0.000000000000000000000000000000000000000000000000000000002535 220.0
HFD1_k127_1846564_2 EF-hand, calcium binding motif - - - 0.00000000000000001536 98.0
HFD1_k127_1848446_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 3.507e-213 672.0
HFD1_k127_1848446_1 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006785 605.0
HFD1_k127_1848446_2 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005773 498.0
HFD1_k127_1848446_3 transcriptional regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 398.0
HFD1_k127_1848446_4 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004925 361.0
HFD1_k127_1848446_5 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001969 261.0
HFD1_k127_1848446_6 Belongs to the UPF0335 family - - - 0.0000000000000000000000000000000147 128.0
HFD1_k127_1862492_0 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 0.0 1206.0
HFD1_k127_1862492_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 6.9e-319 995.0
HFD1_k127_1862492_10 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000001192 241.0
HFD1_k127_1862492_11 Protein-disulfide isomerase - - - 0.00000000000000000000000000000000000000000000000000116 188.0
HFD1_k127_1862492_12 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000009987 142.0
HFD1_k127_1862492_2 Belongs to the IlvD Edd family K01690 - 4.2.1.12 7.08e-305 946.0
HFD1_k127_1862492_3 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 2.563e-210 669.0
HFD1_k127_1862492_4 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 2.404e-202 634.0
HFD1_k127_1862492_5 Peptidase M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 575.0
HFD1_k127_1862492_6 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 377.0
HFD1_k127_1862492_7 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 344.0
HFD1_k127_1862492_8 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008797 286.0
HFD1_k127_1862492_9 Aldolase K01625 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 4.1.2.14,4.1.3.42 0.000000000000000000000000000000000000000000000000000000000000000000000000003086 261.0
HFD1_k127_1890112_0 Dicarboxylate transport - - - 0.0 1078.0
HFD1_k127_1890112_1 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000001118 236.0
HFD1_k127_1890112_2 Domain of unknown function (DUF4163) - - - 0.0000000000000000000000000000000000000000000000000007511 198.0
HFD1_k127_1890112_3 protein conserved in bacteria K09978 - - 0.000000000000000000000000000000001179 137.0
HFD1_k127_1890112_4 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000001045 108.0
HFD1_k127_1890112_5 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00000000000000000000001213 103.0
HFD1_k127_1890112_6 Nickel/cobalt transporter regulator - - - 0.00000000000000000001475 91.0
HFD1_k127_1890112_7 YnbE-like lipoprotein - - - 0.00000000000009822 81.0
HFD1_k127_1890112_8 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000009301 63.0
HFD1_k127_1893324_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 2.513e-274 848.0
HFD1_k127_1893324_1 DNA polymerase K02337 - 2.7.7.7 7.558e-197 624.0
HFD1_k127_1913802_0 COG2801 Transposase and inactivated derivatives K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 527.0
HFD1_k127_1913802_1 Transposase K07483 - - 0.0000000000000000000000000000000000000000000007894 167.0
HFD1_k127_1913802_2 Holin of 3TMs, for gene-transfer release - - - 0.000000000000000000000000000000000004516 143.0
HFD1_k127_1913802_3 SOS response associated peptidase (SRAP) - - - 0.000000000000000000000000009796 111.0
HFD1_k127_1940462_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 498.0
HFD1_k127_1940462_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000002872 218.0
HFD1_k127_1940462_2 Regulatory protein, FmdB family - - - 0.0000000000000000003959 90.0
HFD1_k127_1958557_0 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain K03974 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 525.0
HFD1_k127_1958557_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 515.0
HFD1_k127_1958557_10 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001532 251.0
HFD1_k127_1958557_11 SufE protein probably involved in Fe-S center assembly K02426 - - 0.0000000000000000000000000000000000000000000000000000000002707 205.0
HFD1_k127_1958557_12 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000367 196.0
HFD1_k127_1958557_13 PspC domain K03973 - - 0.000000000000000000000000000000000000000004546 160.0
HFD1_k127_1958557_14 Phage shock protein B K03970 - - 0.00000000000000000000000000000007383 126.0
HFD1_k127_1958557_15 - - - - 0.00000000000000000000000000005459 123.0
HFD1_k127_1958557_16 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.000000000000000000000006879 100.0
HFD1_k127_1958557_17 methyltransferase - - - 0.0000000000000000000001279 101.0
HFD1_k127_1958557_18 - - - - 0.00000000007709 66.0
HFD1_k127_1958557_2 ABC transporter, ATP-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 453.0
HFD1_k127_1958557_21 - - - - 0.0000007985 54.0
HFD1_k127_1958557_3 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 416.0
HFD1_k127_1958557_4 2-methylthioadenine K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 406.0
HFD1_k127_1958557_5 Rieske 2Fe-2S - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 367.0
HFD1_k127_1958557_6 probably involved in intracellular septation K06190 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 317.0
HFD1_k127_1958557_7 Phage shock protein A K03969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000926 303.0
HFD1_k127_1958557_8 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 292.0
HFD1_k127_1958557_9 DnaJ molecular chaperone homology domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006828 266.0
HFD1_k127_2000501_0 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 383.0
HFD1_k127_2000501_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 376.0
HFD1_k127_2000501_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001848 279.0
HFD1_k127_2000501_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004747 276.0
HFD1_k127_2000501_4 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000007981 206.0
HFD1_k127_2000501_5 GcrA cell cycle regulator K13583 - - 0.0000000000000006158 76.0
HFD1_k127_2006648_0 Flp pilus assembly protein, ATPase CpaE K02282 - - 9.334e-232 722.0
HFD1_k127_2006648_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 5.577e-225 704.0
HFD1_k127_2006648_10 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 341.0
HFD1_k127_2006648_11 Glycine dehydrogenase (aminomethyl-transferring) K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000002054 253.0
HFD1_k127_2006648_12 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000003786 238.0
HFD1_k127_2006648_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001121 234.0
HFD1_k127_2006648_14 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000000000000000000001326 217.0
HFD1_k127_2006648_15 Pilus assembly protein CpaD K02281 - - 0.0000000000000000000000000000000000000000000000000006747 193.0
HFD1_k127_2006648_16 peptidase K02278 - 3.4.23.43 0.0000000000000000000000000000000000000000004813 163.0
HFD1_k127_2006648_2 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 613.0
HFD1_k127_2006648_3 type II secretion system protein K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 528.0
HFD1_k127_2006648_4 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007047 494.0
HFD1_k127_2006648_5 Glycine cleavage system T protein K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008248 491.0
HFD1_k127_2006648_6 Belongs to the GSP D family K02280 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 494.0
HFD1_k127_2006648_7 Pilus assembly protein CpaB K02279 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 456.0
HFD1_k127_2006648_8 pilus assembly protein TadB K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005007 428.0
HFD1_k127_2006648_9 Oxidoreductase K19746 - 1.4.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 406.0
HFD1_k127_2019740_0 ATP-dependent DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 4.839e-214 670.0
HFD1_k127_2019740_1 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 543.0
HFD1_k127_2019740_10 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000001083 196.0
HFD1_k127_2019740_2 peptidase S10 serine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 538.0
HFD1_k127_2019740_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007917 512.0
HFD1_k127_2019740_4 ABC-type (Unclassified) transport system, ATPase component K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 407.0
HFD1_k127_2019740_5 endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 369.0
HFD1_k127_2019740_6 Cold shock K03704 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006593 351.0
HFD1_k127_2019740_7 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 336.0
HFD1_k127_2019740_8 Protein conserved in bacteria K11719 - - 0.0000000000000000000000000000000000000000000000000000000000000000003099 237.0
HFD1_k127_2019740_9 protein conserved in bacteria K09774 - - 0.000000000000000000000000000000000000000000000000000000000000003548 227.0
HFD1_k127_2024486_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005678 575.0
HFD1_k127_2024486_1 NnrU protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000003294 235.0
HFD1_k127_2024486_2 amidohydrolase - - - 0.0000000000000000000001918 98.0
HFD1_k127_2045338_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 1.67e-233 734.0
HFD1_k127_2045338_1 May be involved in recombinational repair of damaged DNA K03631 - - 4.791e-206 655.0
HFD1_k127_2045338_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 439.0
HFD1_k127_2045338_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 363.0
HFD1_k127_2045338_4 Protein of unknown function (DUF1697) - - - 0.0000000000000008412 79.0
HFD1_k127_2045338_5 Protein conserved in bacteria - - - 0.000000000001011 74.0
HFD1_k127_2067474_0 membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 480.0
HFD1_k127_2067474_1 protein conserved in bacteria - - - 0.000000000000000000000000000006986 125.0
HFD1_k127_2067474_2 import inner membrane translocase, subunit Tim44 - - - 0.00000000000006958 71.0
HFD1_k127_2067474_3 response regulator - - - 0.000000000009521 66.0
HFD1_k127_209769_0 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.0 1063.0
HFD1_k127_209769_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 5.993e-218 683.0
HFD1_k127_209769_10 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000001419 139.0
HFD1_k127_209769_11 Domain of unknown function (DUF202) K00389 - - 0.0000000000000000000000000000004271 129.0
HFD1_k127_209769_12 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000481 102.0
HFD1_k127_209769_13 Ribosomal protein L30 K02907 - - 0.00000000000000000000001246 101.0
HFD1_k127_209769_15 - - - - 0.000458 48.0
HFD1_k127_209769_2 FAD linked - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 597.0
HFD1_k127_209769_3 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009505 406.0
HFD1_k127_209769_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 368.0
HFD1_k127_209769_5 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 339.0
HFD1_k127_209769_6 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 333.0
HFD1_k127_209769_7 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007443 261.0
HFD1_k127_209769_8 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000000000000000000000000000000000000007357 205.0
HFD1_k127_209769_9 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000005029 182.0
HFD1_k127_212705_0 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000005513 217.0
HFD1_k127_212705_1 - - - - 0.00000000000000008204 83.0
HFD1_k127_212705_2 Domain of unknown function (DUF202) K00389 - - 0.00000000000003759 74.0
HFD1_k127_212705_3 Domain of unknown function (DUF4287) - - - 0.000000000005396 69.0
HFD1_k127_216733_0 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000005326 164.0
HFD1_k127_216733_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000183 163.0
HFD1_k127_216733_2 Pfam:Pyridox_oxidase - - - 0.00000000000000000000000000009002 121.0
HFD1_k127_216733_3 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000006944 66.0
HFD1_k127_217973_0 enoyl-CoA hydratase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 373.0
HFD1_k127_217973_1 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 297.0
HFD1_k127_217973_2 beta' subunit K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009747 284.0
HFD1_k127_217973_3 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000000000001686 151.0
HFD1_k127_217973_4 Protein of unknown function (DUF3309) - - - 0.0000000000000000006343 87.0
HFD1_k127_2200394_0 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007476 323.0
HFD1_k127_2200394_1 Threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000004038 201.0
HFD1_k127_2200394_2 Periplasmic Protein - - - 0.00000000000000000000007044 105.0
HFD1_k127_2200394_3 KTSC domain - - - 0.00000000000002375 81.0
HFD1_k127_2228045_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 599.0
HFD1_k127_2228045_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000164 113.0
HFD1_k127_2228045_2 photosynthesis - - - 0.0000000000000001268 79.0
HFD1_k127_2228045_3 - - - - 0.0000166 49.0
HFD1_k127_2306477_0 Ferrous iron transport protein B K04759 - - 6.489e-284 884.0
HFD1_k127_2306477_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 8.083e-226 704.0
HFD1_k127_2306477_10 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000000000000000000000000005254 217.0
HFD1_k127_2306477_11 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000001522 206.0
HFD1_k127_2306477_12 Uncharacterized ACR, COG1399 - - - 0.000000000000000000000000000000000000000000000000000003464 195.0
HFD1_k127_2306477_13 Small protein A (tmRNA-binding) - - - 0.00000000000000000000000000000000000000000000007397 173.0
HFD1_k127_2306477_14 Ubiquinol-cytochrome C chaperone K17662 - - 0.0000000000000000000000000000000006486 144.0
HFD1_k127_2306477_15 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.000000000000000000000000001082 116.0
HFD1_k127_2306477_16 Fe2 transport system protein A K04758 - - 0.0000000000000000000000004049 106.0
HFD1_k127_2306477_17 - - - - 0.000006097 56.0
HFD1_k127_2306477_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.163e-194 623.0
HFD1_k127_2306477_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007177 529.0
HFD1_k127_2306477_4 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004588 466.0
HFD1_k127_2306477_5 NADH flavin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 444.0
HFD1_k127_2306477_6 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 366.0
HFD1_k127_2306477_7 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009112 354.0
HFD1_k127_2306477_8 Riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000134 284.0
HFD1_k127_2306477_9 RpsU-divergently transcribed K18587 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001179 253.0
HFD1_k127_2307064_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 6.569e-210 673.0
HFD1_k127_2307064_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 607.0
HFD1_k127_2307064_10 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 316.0
HFD1_k127_2307064_11 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005478 289.0
HFD1_k127_2307064_12 Competence protein - - - 0.000000000000000000000000000000000000000000000000000000000000000005424 238.0
HFD1_k127_2307064_13 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.000000000000000000000000000000000000000000000000000000000004367 213.0
HFD1_k127_2307064_14 Domain of unknown function (DUF2383) - - - 0.000000000000000000000000000000000000000000000000000552 187.0
HFD1_k127_2307064_15 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000002136 181.0
HFD1_k127_2307064_16 protein conserved in bacteria - - - 0.0000000000000000000000000000000000008597 143.0
HFD1_k127_2307064_18 NifU homolog involved in Fe-S cluster formation - - - 0.000000000000000000000000000632 121.0
HFD1_k127_2307064_19 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000001017 113.0
HFD1_k127_2307064_2 peptidase M48, Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 577.0
HFD1_k127_2307064_20 Colicin V production protein K03558 - - 0.00000000000000008147 81.0
HFD1_k127_2307064_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 574.0
HFD1_k127_2307064_4 phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 543.0
HFD1_k127_2307064_5 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 479.0
HFD1_k127_2307064_6 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 399.0
HFD1_k127_2307064_7 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 375.0
HFD1_k127_2307064_8 GTP cyclohydrolase K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 355.0
HFD1_k127_2307064_9 FAD-NAD(P)-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 362.0
HFD1_k127_2462523_0 Heat shock 70 kDa protein K04043 - - 0.0 1079.0
HFD1_k127_2462523_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 3.424e-230 718.0
HFD1_k127_2462523_2 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 531.0
HFD1_k127_2462523_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 473.0
HFD1_k127_2462523_4 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 416.0
HFD1_k127_2462523_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 395.0
HFD1_k127_2462523_6 Glycosyltransferase family 87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 402.0
HFD1_k127_2462523_7 Belongs to the UPF0758 family K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 321.0
HFD1_k127_2462523_8 Nickel/cobalt transporter regulator - - - 0.000000000000000000000000000005981 128.0
HFD1_k127_2462523_9 Phytochrome central region domain protein - - - 0.0000000000000000000000000001203 126.0
HFD1_k127_2466810_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1637.0
HFD1_k127_2466810_1 Histidine kinase - - - 1.567e-257 811.0
HFD1_k127_2491494_0 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 394.0
HFD1_k127_2491494_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 329.0
HFD1_k127_2491494_2 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 308.0
HFD1_k127_2491494_3 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 286.0
HFD1_k127_2491494_4 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000001676 212.0
HFD1_k127_2491494_5 Putative tRNA binding domain K06878 - - 0.000000000000000000000000000000000000000000000000005882 183.0
HFD1_k127_2491494_6 amino acid K03294 - - 0.00000000000000000000003005 102.0
HFD1_k127_2495103_0 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 591.0
HFD1_k127_2495103_1 ICC-like phosphoesterases K06953 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 345.0
HFD1_k127_2495103_2 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000009403 170.0
HFD1_k127_2495103_3 component I K01665,K03342 - 2.6.1.85,4.1.3.38 0.00000000000000000000007424 100.0
HFD1_k127_2497710_0 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 5.85e-220 689.0
HFD1_k127_2497710_1 Glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 569.0
HFD1_k127_2497710_2 Conserved TM helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 553.0
HFD1_k127_2497710_3 transcriptional - - - 0.000000000000000000000000000000000000000000000000000001519 201.0
HFD1_k127_2497710_4 Uracil-DNA glycosylase superfamily - - - 0.000000000000000000000000000000000000000000000005636 177.0
HFD1_k127_2497710_6 YjbR - - - 0.00000000000000000000000000000003238 128.0
HFD1_k127_2497710_7 P-type ATPase K17686 - 3.6.3.54 0.000002897 49.0
HFD1_k127_2497710_8 - - - - 0.000004404 50.0
HFD1_k127_2525027_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1523.0
HFD1_k127_2525027_1 Helicase K03722 - 3.6.4.12 0.0 1311.0
HFD1_k127_2525027_10 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000003827 252.0
HFD1_k127_2525027_11 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000007772 233.0
HFD1_k127_2525027_12 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000002738 210.0
HFD1_k127_2525027_13 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000758 215.0
HFD1_k127_2525027_14 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000000001007 170.0
HFD1_k127_2525027_15 phosphohistidine phosphatase K08296 - - 0.0000000000000000000000000000000000000000000001758 173.0
HFD1_k127_2525027_16 Cytochrome c - - - 0.0000000000000000000000000000000001373 139.0
HFD1_k127_2525027_17 transcriptional - - - 0.000000000000000000000000000000004671 132.0
HFD1_k127_2525027_18 TIR domain - - - 0.00000000000000000000000000001099 136.0
HFD1_k127_2525027_19 Nickel/cobalt transporter regulator - - - 0.0000000000000000000000000002148 124.0
HFD1_k127_2525027_2 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 0.0 1166.0
HFD1_k127_2525027_21 Outer membrane efflux protein - - - 0.000000000001218 77.0
HFD1_k127_2525027_22 - - - - 0.000000000004991 72.0
HFD1_k127_2525027_23 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.00006582 50.0
HFD1_k127_2525027_3 protein conserved in bacteria - - - 3.291e-298 925.0
HFD1_k127_2525027_4 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 3.153e-253 793.0
HFD1_k127_2525027_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 512.0
HFD1_k127_2525027_6 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005066 402.0
HFD1_k127_2525027_7 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 339.0
HFD1_k127_2525027_8 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 305.0
HFD1_k127_2525027_9 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 303.0
HFD1_k127_2562104_0 5-methyltetrahydrofolate--homocysteine methyltransferase K00548 - 2.1.1.13 2.686e-216 680.0
HFD1_k127_2562104_1 Methionine synthase I (cobalamin-dependent), methyltransferase domain K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 469.0
HFD1_k127_2562104_2 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 467.0
HFD1_k127_2562104_3 ArsR family transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 404.0
HFD1_k127_2562104_4 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000000000000000000000000000000000000000000000007569 193.0
HFD1_k127_2562304_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 3.905e-244 761.0
HFD1_k127_2562304_1 signal peptide peptidase K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 369.0
HFD1_k127_2562304_2 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 355.0
HFD1_k127_2562304_3 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000001358 191.0
HFD1_k127_256703_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.0 1028.0
HFD1_k127_256703_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 384.0
HFD1_k127_256703_2 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005644 242.0
HFD1_k127_256703_3 Phenazine biosynthesis protein PhzF K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000006469 238.0
HFD1_k127_256703_4 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000008399 204.0
HFD1_k127_256703_5 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000001375 141.0
HFD1_k127_2581526_0 Belongs to the GPI family K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 3.593e-201 637.0
HFD1_k127_2581526_1 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 407.0
HFD1_k127_2581526_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 341.0
HFD1_k127_2581526_3 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 316.0
HFD1_k127_2581526_4 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001572 266.0
HFD1_k127_2581526_5 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.000000000000001956 77.0
HFD1_k127_2622710_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 9.962e-224 699.0
HFD1_k127_2622710_1 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000002118 273.0
HFD1_k127_2638663_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 3.244e-229 716.0
HFD1_k127_2638663_1 Prolyl oligopeptidase family - - - 5.589e-219 694.0
HFD1_k127_2638663_10 amine dehydrogenase activity - - - 0.0000000000006072 79.0
HFD1_k127_2638663_2 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 447.0
HFD1_k127_2638663_3 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 344.0
HFD1_k127_2638663_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 342.0
HFD1_k127_2638663_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007492 341.0
HFD1_k127_2638663_6 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006898 334.0
HFD1_k127_2638663_7 COG0739 Membrane proteins related to metalloendopeptidases K21472 - - 0.00000000000000000000000000000000000000000000000000000000001708 215.0
HFD1_k127_2638663_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000008533 202.0
HFD1_k127_2638663_9 NADH dehydrogenase K00334 - 1.6.5.3 0.00000000000000000000000000000000000001542 153.0
HFD1_k127_2642727_0 Amidohydrolase family K06015 - 3.5.1.81 9.273e-244 766.0
HFD1_k127_2642727_1 UDP-N-acetylmuramate-alanine ligase K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 537.0
HFD1_k127_2642727_2 fatty acid desaturase K00508 - 1.14.19.3 0.0000000000000000000000000000000000000000000000004739 192.0
HFD1_k127_2642785_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1196.0
HFD1_k127_2642785_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 8.132e-289 891.0
HFD1_k127_2642785_10 Protein of unknown function (DUF1203) - - - 0.00000000000000000000000000000000000000000000001305 178.0
HFD1_k127_2642785_11 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000003206 130.0
HFD1_k127_2642785_12 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 - - 0.00000000000000000000000000000466 120.0
HFD1_k127_2642785_13 Acetyltransferase (GNAT) domain K03829 - - 0.0000000000000000000000007211 113.0
HFD1_k127_2642785_14 Acetyltransferase (GNAT) domain K03829 - - 0.000000000006335 66.0
HFD1_k127_2642785_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 6.121e-277 857.0
HFD1_k127_2642785_3 Flp pilus assembly protein, ATPase CpaF K02283 - - 8.187e-251 781.0
HFD1_k127_2642785_4 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 481.0
HFD1_k127_2642785_5 Metal binding domain of Ada K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 434.0
HFD1_k127_2642785_6 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000768 395.0
HFD1_k127_2642785_7 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 377.0
HFD1_k127_2642785_8 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004615 259.0
HFD1_k127_2642785_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006849 244.0
HFD1_k127_2652818_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 0.0 1147.0
HFD1_k127_2652818_1 peptidase S9 - - - 3.123e-306 948.0
HFD1_k127_2652818_10 protein conserved in bacteria K09991 - - 0.000000000000000000000000000000004671 132.0
HFD1_k127_2652818_11 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000006074 130.0
HFD1_k127_2652818_12 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000177 121.0
HFD1_k127_2652818_13 diguanylate cyclase - - - 0.0000000000000001094 93.0
HFD1_k127_2652818_14 transferase activity, transferring glycosyl groups - - - 0.00002219 50.0
HFD1_k127_2652818_15 - - - - 0.0001648 50.0
HFD1_k127_2652818_16 - - - - 0.0004584 47.0
HFD1_k127_2652818_2 membrane K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 576.0
HFD1_k127_2652818_3 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 501.0
HFD1_k127_2652818_4 NnrS protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 494.0
HFD1_k127_2652818_5 nitrogen fixation sensor protein fixL K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 447.0
HFD1_k127_2652818_6 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 442.0
HFD1_k127_2652818_7 part of global network that controls expression of aerobic respiratory terminal oxidases and carbon and nitrogen metabolic enzymes K14987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001417 280.0
HFD1_k127_2652818_8 LacY proton/sugar symporter K02575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001167 263.0
HFD1_k127_2652818_9 protein-L-isoaspartate K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000001335 213.0
HFD1_k127_2662317_0 peptidase U62, modulator of DNA gyrase K03568 - - 2.131e-237 741.0
HFD1_k127_2662317_1 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009883 469.0
HFD1_k127_2662317_2 Peptidase family M3 K01284 - 3.4.15.5 0.0000000000000000000000000000000000000000000000000000002357 198.0
HFD1_k127_2662317_3 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000008898 197.0
HFD1_k127_2662317_4 protein conserved in bacteria - - - 0.00000000000000000000000000000000355 135.0
HFD1_k127_2662317_5 protein conserved in bacteria - - - 0.0000000000000000000002511 99.0
HFD1_k127_2662317_6 Putative prokaryotic signal transducing protein - - - 0.0000002806 56.0
HFD1_k127_2663887_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006067 372.0
HFD1_k127_2663887_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 304.0
HFD1_k127_2663887_3 CHASE2 - - - 0.0000000000000000000000000000000000000000002989 164.0
HFD1_k127_2663887_4 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000001109 157.0
HFD1_k127_2681255_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 4.34e-280 865.0
HFD1_k127_2681255_1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 7.46e-210 671.0
HFD1_k127_2681255_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 404.0
HFD1_k127_2681255_3 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002482 252.0
HFD1_k127_2681255_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003964 243.0
HFD1_k127_2681255_5 - - - - 0.0000000000000000000000000000000000000000000000000000000003042 218.0
HFD1_k127_2681255_6 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000005453 183.0
HFD1_k127_2681255_7 protein conserved in bacteria K09928 - - 0.0000000000000000000000000000000000006217 148.0
HFD1_k127_2700889_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1321.0
HFD1_k127_2700889_1 peptidase M13 K07386 - - 3.306e-306 950.0
HFD1_k127_2700889_2 Histidine kinase K13587 - 2.7.13.3 2.286e-268 847.0
HFD1_k127_2700889_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 1.881e-250 776.0
HFD1_k127_2700889_4 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 352.0
HFD1_k127_2700889_5 cyclic nucleotide binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 305.0
HFD1_k127_2700889_6 COG1073 hydrolases of the alpha beta superfamily K06889 - - 0.000000000000000000000000000000000000000000000000000000000000134 225.0
HFD1_k127_2700889_7 Histidine triad (HIT) protein - - - 0.000000000000000000000000000000000000000000000000007892 184.0
HFD1_k127_2700889_8 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000001434 158.0
HFD1_k127_2700889_9 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000001552 137.0
HFD1_k127_271110_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1083.0
HFD1_k127_271110_1 protein conserved in bacteria - - - 3.169e-220 697.0
HFD1_k127_271110_10 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000000000000000000002752 211.0
HFD1_k127_271110_11 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000000000000000000007343 184.0
HFD1_k127_271110_12 X-Pro dipeptidyl-peptidase domain protein K06978 - - 0.00000000000000000000000000000000000000000000001051 172.0
HFD1_k127_271110_13 Membrane-bound metallopeptidase - - - 0.000000000000000000000000000000000000000000000245 182.0
HFD1_k127_271110_14 Disulfide bond formation protein - - - 0.00000000000000000000000000000000000000000001499 168.0
HFD1_k127_271110_15 - - - - 0.000000000000000000000000000001057 125.0
HFD1_k127_271110_2 Belongs to the peptidase S41A family K03797 - 3.4.21.102 3.831e-214 672.0
HFD1_k127_271110_3 amino acid peptide transporter K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 397.0
HFD1_k127_271110_4 beta-lactamase K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 337.0
HFD1_k127_271110_5 Protein of unknown function (DUF3667) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006714 308.0
HFD1_k127_271110_6 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001775 276.0
HFD1_k127_271110_7 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005738 278.0
HFD1_k127_271110_8 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002509 274.0
HFD1_k127_271110_9 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000001413 236.0
HFD1_k127_271797_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 2.865e-251 784.0
HFD1_k127_271797_1 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004656 360.0
HFD1_k127_271797_2 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 291.0
HFD1_k127_271797_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002948 276.0
HFD1_k127_271797_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000000000000000008017 201.0
HFD1_k127_271797_5 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000004935 164.0
HFD1_k127_278471_0 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 1.151e-278 870.0
HFD1_k127_278471_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 3.72e-197 617.0
HFD1_k127_278471_10 Protein of unknown function (FYDLN_acid) - - - 0.0000000000000000000000000000001748 134.0
HFD1_k127_278471_2 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006326 453.0
HFD1_k127_278471_3 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007198 445.0
HFD1_k127_278471_4 Serine aminopeptidase, S33 K18457 - 3.5.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 407.0
HFD1_k127_278471_5 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 376.0
HFD1_k127_278471_6 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 298.0
HFD1_k127_278471_7 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000000000000000000000000000000004903 203.0
HFD1_k127_278471_8 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000002104 203.0
HFD1_k127_278471_9 Protein of unknown function (DUF4230) - - - 0.000000000000000000000000000000000000000000000000001821 192.0
HFD1_k127_2838025_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1109.0
HFD1_k127_2838025_1 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 508.0
HFD1_k127_2838025_2 Aminomethyltransferase K06980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 355.0
HFD1_k127_2838025_3 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 311.0
HFD1_k127_2838025_4 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003793 266.0
HFD1_k127_2838025_5 - - - - 0.000000000000000000001925 96.0
HFD1_k127_2838215_0 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 1.228e-207 652.0
HFD1_k127_2838215_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 528.0
HFD1_k127_2838215_2 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004905 514.0
HFD1_k127_2838215_3 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 383.0
HFD1_k127_2838215_4 ATPase involved in DNA replication - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 289.0
HFD1_k127_2838215_5 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000001418 244.0
HFD1_k127_2838215_6 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000002752 222.0
HFD1_k127_2838215_7 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate - - - 0.0000000000000000000000000000000000000000001902 161.0
HFD1_k127_2838215_8 Peptidase inhibitor I78 family - - - 0.0000000000009955 72.0
HFD1_k127_2838215_9 - - - - 0.000000007841 66.0
HFD1_k127_2869246_0 TonB dependent receptor - - - 0.0 1056.0
HFD1_k127_2869246_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 571.0
HFD1_k127_2869246_10 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000000000005809 213.0
HFD1_k127_2869246_11 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000000000000000000000000541 157.0
HFD1_k127_2869246_12 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000003328 134.0
HFD1_k127_2869246_2 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000541 519.0
HFD1_k127_2869246_3 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 506.0
HFD1_k127_2869246_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 471.0
HFD1_k127_2869246_5 Belongs to the 'phage' integrase family K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 396.0
HFD1_k127_2869246_6 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 384.0
HFD1_k127_2869246_7 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 345.0
HFD1_k127_2869246_8 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000007109 268.0
HFD1_k127_2869246_9 Protein of unknown function, DUF484 K09921 - - 0.00000000000000000000000000000000000000000000000000000000000006096 220.0
HFD1_k127_2881756_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005777 291.0
HFD1_k127_2881756_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005036 278.0
HFD1_k127_2881756_2 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.00000000000000000000000000000005369 131.0
HFD1_k127_2881756_3 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000000000005864 119.0
HFD1_k127_2917846_0 Asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 345.0
HFD1_k127_2917846_1 DNA mediated transformation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006504 284.0
HFD1_k127_2917846_2 protein conserved in bacteria K09919 - - 0.00000000000000000000000000000000000000000000000000002768 190.0
HFD1_k127_2966475_0 Transport of potassium into the cell - - - 4.424e-306 949.0
HFD1_k127_2966475_1 Domain of unknown function (DUF4118) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 338.0
HFD1_k127_3159087_0 NADH ubiquinone oxidoreductase subunit K00341 - 1.6.5.3 0.0 1065.0
HFD1_k127_3159087_1 metallo-beta-lactamase K12574 - - 2.164e-240 754.0
HFD1_k127_3159087_2 NADH ubiquinone oxidoreductase subunit K00342 - 1.6.5.3 2.564e-232 730.0
HFD1_k127_3159087_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 9.827e-200 632.0
HFD1_k127_3159087_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 412.0
HFD1_k127_3159087_5 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 293.0
HFD1_k127_3159087_6 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000001327 214.0
HFD1_k127_3159087_7 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000001847 177.0
HFD1_k127_3159087_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000000001916 156.0
HFD1_k127_3159087_9 Protein of unknown function (DUF1467) - - - 0.00000000000000000000000003529 109.0
HFD1_k127_3165001_0 helicase K16899 - 3.6.4.12 2.28e-249 789.0
HFD1_k127_3165001_1 Phosphotransferase K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 489.0
HFD1_k127_3165001_2 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 388.0
HFD1_k127_3247475_0 MaoC like domain K02618 - 1.2.1.91,3.3.2.12 0.0 1086.0
HFD1_k127_3247475_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008034 278.0
HFD1_k127_3247475_2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000000000000000000000000000000002674 164.0
HFD1_k127_3247475_3 CBS domain - - - 0.0000000000000000000000000000000000000003289 154.0
HFD1_k127_3247475_4 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000004305 139.0
HFD1_k127_3247475_5 beta' subunit K01754 - 4.3.1.19 0.00000000000000000000000000002023 123.0
HFD1_k127_3247475_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000000003852 111.0
HFD1_k127_3250482_0 peptidase S9 K01354 - 3.4.21.83 0.0 1015.0
HFD1_k127_3250482_1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 579.0
HFD1_k127_3250482_2 Dehydrogenase K00101 - 1.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 509.0
HFD1_k127_3250482_3 Aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 452.0
HFD1_k127_3250482_4 maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000006704 269.0
HFD1_k127_3250482_5 thioesterase K07107 - - 0.000000000000000000000000000000000000000000000000000652 188.0
HFD1_k127_3250482_6 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000005693 145.0
HFD1_k127_3250482_7 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.0000000001049 64.0
HFD1_k127_3255794_0 Bacterial protein of unknown function (DUF853) K06915 - - 8.05e-227 716.0
HFD1_k127_3255794_1 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000009921 88.0
HFD1_k127_3255794_2 - - - - 0.00000000000005835 79.0
HFD1_k127_3278851_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007394 528.0
HFD1_k127_3278851_1 Domain of unknown function (DUF4424) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002385 280.0
HFD1_k127_3278851_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000006857 244.0
HFD1_k127_3278851_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000002353 229.0
HFD1_k127_3278851_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000000000000000000000000000744 208.0
HFD1_k127_3278851_5 Cupin 2, conserved barrel - - - 0.0000000000000000000000000000000000000000000000000000002583 196.0
HFD1_k127_3278851_6 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000000000000000000001721 135.0
HFD1_k127_3308041_0 Predicted permease K07089 - - 2.489e-197 626.0
HFD1_k127_3308041_1 Thioredoxin domain - - - 0.00000000000000000000000000001003 121.0
HFD1_k127_3319280_0 Belongs to the malate synthase family K01638 - 2.3.3.9 2.107e-264 821.0
HFD1_k127_3319280_1 Isocitrate lyase K01637 GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350 4.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008162 501.0
HFD1_k127_3358693_0 Subtilase family - - - 1.612e-201 642.0
HFD1_k127_3358693_1 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009529 311.0
HFD1_k127_3358693_2 FeS assembly SUF system protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000004682 237.0
HFD1_k127_3358693_3 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000000000000000000000000000000000000008595 216.0
HFD1_k127_3367828_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 8.637e-296 911.0
HFD1_k127_3367828_1 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000002532 217.0
HFD1_k127_3367828_2 protein conserved in bacteria - - - 0.00000002291 60.0
HFD1_k127_3375743_0 E1-E2 ATPase K17686 - 3.6.3.54 2.31e-289 904.0
HFD1_k127_3375743_1 copper resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 592.0
HFD1_k127_3375743_2 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000001706 183.0
HFD1_k127_3375743_3 SnoaL-like domain - - - 0.00000000000000000000000000000000000002129 148.0
HFD1_k127_339275_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1035.0
HFD1_k127_339275_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 4.173e-218 684.0
HFD1_k127_339275_10 2 iron, 2 sulfur cluster binding K02192 GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540 - 0.0000000001393 64.0
HFD1_k127_339275_2 Pyrrolo-quinoline quinone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 571.0
HFD1_k127_339275_3 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 467.0
HFD1_k127_339275_4 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 393.0
HFD1_k127_339275_5 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000003893 255.0
HFD1_k127_339275_6 COG1309 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002671 245.0
HFD1_k127_339275_7 Hpt domain K20976 - - 0.00000000000000000000000000000000000000000000000000000000000000002156 226.0
HFD1_k127_339275_8 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000000000000000000000000000006471 200.0
HFD1_k127_339275_9 - - - - 0.0000000000000000000000000000255 122.0
HFD1_k127_34368_0 Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 503.0
HFD1_k127_34368_1 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001382 252.0
HFD1_k127_3437493_0 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 595.0
HFD1_k127_3437493_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000000000002049 221.0
HFD1_k127_3437493_2 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.000000000000001303 77.0
HFD1_k127_3489982_0 Elongation factor G, domain IV K02355 - - 1.75e-288 899.0
HFD1_k127_3489982_1 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 422.0
HFD1_k127_3489982_2 PFAM polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 339.0
HFD1_k127_3489982_3 SIS domain K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 317.0
HFD1_k127_3489982_4 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 289.0
HFD1_k127_3489982_5 3-deoxy-manno-octulosonate cytidylyltransferase K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001916 278.0
HFD1_k127_3489982_6 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000904 252.0
HFD1_k127_3489982_7 sugar phosphatases of the HAD superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004536 251.0
HFD1_k127_3489982_8 transcriptional K05800 - - 0.00000000000000000000000000000000000006548 147.0
HFD1_k127_3531745_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 9.358e-247 766.0
HFD1_k127_3531745_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 5.748e-214 674.0
HFD1_k127_3531745_2 membrane metal-binding protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 520.0
HFD1_k127_3531745_3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 477.0
HFD1_k127_3531745_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 406.0
HFD1_k127_3531745_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007485 330.0
HFD1_k127_3531745_6 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000004905 168.0
HFD1_k127_3559652_0 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01469 - 3.5.2.9 0.0 1615.0
HFD1_k127_3559652_1 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 484.0
HFD1_k127_3559652_2 epimerase dehydratase K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 479.0
HFD1_k127_3559652_3 Protein of unknown function (DUF1465) K13592 - - 0.0000000000000000000000000000000000000000000000000000000419 203.0
HFD1_k127_3559652_4 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000271 199.0
HFD1_k127_3559652_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000001967 101.0
HFD1_k127_3559652_6 Small protein - - - 0.0000000007844 62.0
HFD1_k127_3559652_7 Protein of unknown function (DUF465) - - - 0.000002238 51.0
HFD1_k127_3566767_0 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003447 404.0
HFD1_k127_3566767_1 protein conserved in bacteria K09987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 369.0
HFD1_k127_3566767_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000000000000205 107.0
HFD1_k127_3566767_3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000434 81.0
HFD1_k127_3583347_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 517.0
HFD1_k127_3583347_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 436.0
HFD1_k127_3583347_10 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000646 172.0
HFD1_k127_3583347_11 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000005361 140.0
HFD1_k127_3583347_12 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000000003567 99.0
HFD1_k127_3583347_13 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000001202 85.0
HFD1_k127_3583347_14 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000006585 78.0
HFD1_k127_3583347_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 335.0
HFD1_k127_3583347_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 300.0
HFD1_k127_3583347_4 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001014 269.0
HFD1_k127_3583347_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009205 246.0
HFD1_k127_3583347_6 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000000001085 237.0
HFD1_k127_3583347_7 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000000000004336 213.0
HFD1_k127_3583347_8 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000000000000000000000000000000003692 182.0
HFD1_k127_3583347_9 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000000000000001152 176.0
HFD1_k127_3619794_0 Belongs to the heme-copper respiratory oxidase family K02298 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.10.3.10 6.058e-308 955.0
HFD1_k127_3619794_1 single-stranded-DNA-specific exonuclease RecJ K07462 - - 8.146e-242 775.0
HFD1_k127_3619794_10 CytOchrome o ubiquinol oxidase K02276,K02299 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002913 268.0
HFD1_k127_3619794_11 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001198 267.0
HFD1_k127_3619794_12 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000412 257.0
HFD1_k127_3619794_13 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000000000000009002 219.0
HFD1_k127_3619794_14 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000000000000000000000000000004972 179.0
HFD1_k127_3619794_15 mannose-6-phosphate isomerase - - - 0.000000000000000000000000000000000000000000000001581 175.0
HFD1_k127_3619794_16 endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000000009051 171.0
HFD1_k127_3619794_17 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K08295 - 6.2.1.32 0.00000000000000000000000000000000000002195 149.0
HFD1_k127_3619794_18 Prokaryotic Cytochrome C oxidase subunit IV K02300 - - 0.00000000000000000000000000000000000006111 155.0
HFD1_k127_3619794_19 - - - - 0.00000000000000000000000000004886 123.0
HFD1_k127_3619794_2 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 2.55e-223 694.0
HFD1_k127_3619794_3 in Escherichia coli this protein forms a dimer and binds manganese K11532 - 3.1.3.11,3.1.3.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 527.0
HFD1_k127_3619794_4 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 458.0
HFD1_k127_3619794_5 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007667 443.0
HFD1_k127_3619794_6 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 375.0
HFD1_k127_3619794_7 Cytochrome C oxidase subunit II, periplasmic domain K02297 - 1.10.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 352.0
HFD1_k127_3619794_8 Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione K03396 - 4.4.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 301.0
HFD1_k127_3619794_9 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 301.0
HFD1_k127_3636196_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 476.0
HFD1_k127_3636196_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 341.0
HFD1_k127_3636196_2 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001155 278.0
HFD1_k127_3636196_3 Hemolysin K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002607 267.0
HFD1_k127_3636196_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000001087 214.0
HFD1_k127_3636196_5 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.00000000000000000000000000000000000000001156 161.0
HFD1_k127_3636196_6 small heat shock protein - - - 0.0000000000000000000000000000000000000474 151.0
HFD1_k127_3636196_7 Membrane fusogenic activity K09806 - - 0.00000000000000000000000000002788 121.0
HFD1_k127_3636196_8 PFAM Cytochrome c, class I - - - 0.000000000000000001529 89.0
HFD1_k127_3636196_9 - - - - 0.000000000004853 74.0
HFD1_k127_3644299_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 1.527e-216 682.0
HFD1_k127_3644299_1 Putative peptidoglycan binding domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005009 431.0
HFD1_k127_3644299_2 Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate K06447 - 1.2.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 406.0
HFD1_k127_3657670_0 type VI secretion protein K11900 - - 1.342e-283 880.0
HFD1_k127_3657670_1 Type VI secretion protein K11896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 482.0
HFD1_k127_3657670_2 Virulence protein SciE type K11898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008739 329.0
HFD1_k127_3657670_3 Type VI secretion system, VipA, VC_A0107 or Hcp2 K11901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005888 284.0
HFD1_k127_3657670_4 ImpA, N-terminal, type VI secretion system K11902 - - 0.00000000000000000000000000000000000000000000000000000000000002621 227.0
HFD1_k127_3657670_5 Type VI secretion system effector, Hcp K11903 - - 0.000000000000000000000000000000000000000000000000002241 187.0
HFD1_k127_3657670_6 TIGRFAM type VI secretion system lysozyme-related protein K11897 - - 0.00000000000000000000000000000000000000000000001471 178.0
HFD1_k127_3657670_7 Type VI secretion system effector, Hcp K11903 - - 0.00000000000000000000000000000000004188 139.0
HFD1_k127_3683761_0 Efflux pump membrane transporter K18138 - - 0.0 1438.0
HFD1_k127_3683761_1 Penicillin-binding Protein K05515 - 3.4.16.4 2.019e-237 756.0
HFD1_k127_3683761_10 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 390.0
HFD1_k127_3683761_11 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 382.0
HFD1_k127_3683761_12 glycosyl transferase family 8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 349.0
HFD1_k127_3683761_13 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01469 - 3.5.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 327.0
HFD1_k127_3683761_14 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 302.0
HFD1_k127_3683761_15 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 298.0
HFD1_k127_3683761_16 Mitochondrial fission ELM1 K07276 - - 0.00000000000000000000000000000000000000000000000000000002152 211.0
HFD1_k127_3683761_17 rod shape-determining protein MreD K03571 - - 0.00000000000000000000000000000000000000000000000000000007244 201.0
HFD1_k127_3683761_18 non-haem dioxygenase in morphine synthesis N-terminal - - - 0.000000000000000000000000000000000000000000000000000012 202.0
HFD1_k127_3683761_19 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000001791 168.0
HFD1_k127_3683761_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 3.399e-234 737.0
HFD1_k127_3683761_20 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000002231 168.0
HFD1_k127_3683761_3 asparagine synthase K01953 - 6.3.5.4 1.209e-224 713.0
HFD1_k127_3683761_4 receptor - - - 5.036e-222 706.0
HFD1_k127_3683761_5 rod shape-determining protein MreB K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 603.0
HFD1_k127_3683761_6 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 492.0
HFD1_k127_3683761_7 RND efflux system, outer membrane lipoprotein K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006647 489.0
HFD1_k127_3683761_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 468.0
HFD1_k127_3683761_9 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 437.0
HFD1_k127_3689906_0 DNA recombination protein K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 425.0
HFD1_k127_3689906_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 335.0
HFD1_k127_3689906_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000009298 260.0
HFD1_k127_3689906_3 Ferredoxin - - - 0.000000000000000000000000000000000000000005435 169.0
HFD1_k127_3754097_0 Thioredoxin reductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 428.0
HFD1_k127_3754097_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 420.0
HFD1_k127_3754097_2 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001966 254.0
HFD1_k127_3754097_3 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000001222 222.0
HFD1_k127_3754097_4 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000002483 199.0
HFD1_k127_3760306_0 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000002317 268.0
HFD1_k127_3760306_1 Belongs to the CinA family K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000002599 207.0
HFD1_k127_3760306_2 Peptidase, M28 - - - 0.0000000000000000000000000000000000000000000000000000003231 196.0
HFD1_k127_3760306_3 dienelactone hydrolase K01061 - 3.1.1.45 0.000000151 52.0
HFD1_k127_3857055_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 1.087e-321 1009.0
HFD1_k127_3857055_1 In Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 448.0
HFD1_k127_3857055_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 364.0
HFD1_k127_3857055_3 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.0000000000000000000000000000000000000004829 151.0
HFD1_k127_3857055_4 Histidine kinase - - - 0.00000000000000000000000000002963 123.0
HFD1_k127_3857055_6 - - - - 0.0006879 45.0
HFD1_k127_3871997_0 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000834 458.0
HFD1_k127_3871997_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 452.0
HFD1_k127_3871997_2 secretion protein K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000002181 244.0
HFD1_k127_3871997_3 COG1538 Outer membrane protein - - - 0.00000000000000000000000000000000001239 141.0
HFD1_k127_3978644_0 Transposase DDE domain - - - 6.399e-196 625.0
HFD1_k127_3983918_0 nitrate reductase beta subunit K00371 - 1.7.5.1 1.19e-284 880.0
HFD1_k127_3983918_1 Uncharacterized ACR, YdiU/UPF0061 family - - - 1.031e-196 622.0
HFD1_k127_3983918_10 nitrate reductase molybdenum cofactor assembly chaperone K00373 - - 0.0000000000000000000000000000000000000000000000000000001579 202.0
HFD1_k127_3983918_11 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) - - - 0.000000000000000000000000000000000000000000000000000001043 202.0
HFD1_k127_3983918_12 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000003084 192.0
HFD1_k127_3983918_13 SCO1/SenC K07152 - - 0.0000000000000000000000000000000000000000000002204 174.0
HFD1_k127_3983918_14 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000007597 180.0
HFD1_k127_3983918_15 Molybdopterin K03635 - 2.8.1.12 0.000000000000000000000000000000000000000001113 161.0
HFD1_k127_3983918_16 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370,K17050 - 1.7.5.1 0.0000000000000000000000000000000000000001039 151.0
HFD1_k127_3983918_19 - - - - 0.00000009817 57.0
HFD1_k127_3983918_2 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 422.0
HFD1_k127_3983918_3 COG2041 Sulfite oxidase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 350.0
HFD1_k127_3983918_4 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 340.0
HFD1_k127_3983918_5 TIGRFAM respiratory nitrate reductase, gamma subunit K00374 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 303.0
HFD1_k127_3983918_6 May be involved in the biosynthesis of molybdopterin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003527 278.0
HFD1_k127_3983918_7 Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate K06447 - 1.2.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000559 258.0
HFD1_k127_3983918_8 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000194 248.0
HFD1_k127_3983918_9 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.000000000000000000000000000000000000000000000000000000000000003377 229.0
HFD1_k127_3994222_0 chemotaxis protein K03407 - 2.7.13.3 0.0 1056.0
HFD1_k127_3994222_1 RNA polymerase sigma K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 520.0
HFD1_k127_3994222_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006119 477.0
HFD1_k127_3994222_3 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006294 436.0
HFD1_k127_3994222_4 COG1352 Methylase of chemotaxis methyl-accepting proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 407.0
HFD1_k127_3994222_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 408.0
HFD1_k127_3994222_6 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 400.0
HFD1_k127_3994222_7 Histidine phosphotransferase C-terminal domain K13588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 298.0
HFD1_k127_3994222_8 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000000000000000000000001085 237.0
HFD1_k127_3994222_9 Two component signalling adaptor domain K03408 - - 0.00000000000000000000000000000000000000000000000000000000005673 208.0
HFD1_k127_400825_0 Sulfate transporter K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 612.0
HFD1_k127_400825_1 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 419.0
HFD1_k127_400825_10 - - - - 0.0000000000000000000000001954 109.0
HFD1_k127_400825_2 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 389.0
HFD1_k127_400825_3 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001713 252.0
HFD1_k127_400825_4 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000001608 166.0
HFD1_k127_400825_5 - - - - 0.000000000000000000000000000000000000000002706 163.0
HFD1_k127_400825_6 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000004485 158.0
HFD1_k127_400825_7 Domain of unknown function (DUF1476) - - - 0.00000000000000000000000000000000002943 143.0
HFD1_k127_400825_8 - - - - 0.0000000000000000000000000000002689 128.0
HFD1_k127_400825_9 Belongs to the BolA IbaG family - - - 0.00000000000000000000000000001376 121.0
HFD1_k127_4037024_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 1.62e-288 893.0
HFD1_k127_4037024_1 protein conserved in bacteria - - - 5.78e-262 820.0
HFD1_k127_4037024_10 - - - - 0.00000000000000000000000000000000000000000000000000000002413 202.0
HFD1_k127_4037024_11 Serine kinase of the HPr protein, regulates carbohydrate metabolism - - - 0.00000000000000000000000000000000000000000000000003051 182.0
HFD1_k127_4037024_12 Domain of unknown function (DUF4136) - - - 0.00000000000000000000000000000000000000000003074 171.0
HFD1_k127_4037024_13 META domain - - - 0.0000000000000000000000000000000009745 137.0
HFD1_k127_4037024_14 COG1925 Phosphotransferase system, HPr-related proteins K11189 - - 0.00000000000000000000000000114 119.0
HFD1_k127_4037024_2 Protein conserved in bacteria - - - 2.364e-241 758.0
HFD1_k127_4037024_3 Histidine kinase K14980 - 2.7.13.3 2.891e-197 629.0
HFD1_k127_4037024_4 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 521.0
HFD1_k127_4037024_5 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 400.0
HFD1_k127_4037024_6 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 374.0
HFD1_k127_4037024_7 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K14981 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 363.0
HFD1_k127_4037024_8 DNA recombination protein K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 289.0
HFD1_k127_4037024_9 PTS fructose transporter subunit IIA K02793 - 2.7.1.191 0.00000000000000000000000000000000000000000000000000000000000002035 218.0
HFD1_k127_4046420_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 332.0
HFD1_k127_4046420_1 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000000000000000000000000000001731 233.0
HFD1_k127_4046420_2 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.0000000000000000000000000000000000000000000000000000000000000007366 224.0
HFD1_k127_4046420_3 COG3773 Cell wall hydrolyses involved in spore germination - - - 0.00000000000000000000000000000000000000000000000000000000002914 213.0
HFD1_k127_4046420_4 PTS IIA-like nitrogen-regulatory protein PtsN K02806 - - 0.00000000000000000000000000000000000000000000000000000000007627 209.0
HFD1_k127_4046420_5 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000003536 193.0
HFD1_k127_4046420_6 Protein of unknown function (DUF1491) - - - 0.00000000000000003053 91.0
HFD1_k127_4046420_7 DNA repair protein MmcB-like - - - 0.00000000001572 74.0
HFD1_k127_4052933_0 amino acid K03294 - - 2.466e-257 804.0
HFD1_k127_4052933_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.14e-202 640.0
HFD1_k127_4052933_2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 504.0
HFD1_k127_4052933_3 Carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 397.0
HFD1_k127_4052933_4 CorA-like Mg2+ transporter protein K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008645 379.0
HFD1_k127_4052933_5 protein conserved in bacteria K09985 - - 0.0000000000000000000000000000000000000000000000000000000000000001047 225.0
HFD1_k127_4052933_6 Protein of unknown function (DUF2585) - - - 0.0000000000000000000000000000000000000000000000000000000000000001414 226.0
HFD1_k127_4052933_7 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000001985 219.0
HFD1_k127_4052933_8 Lipid A 3-O-deacylase (PagL) - - - 0.000000000000000000000000000000000000000000000000000000001111 206.0
HFD1_k127_4058816_0 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 4.357e-306 954.0
HFD1_k127_4058816_1 ABC transporter - - - 5.442e-273 842.0
HFD1_k127_4058816_10 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 543.0
HFD1_k127_4058816_11 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 445.0
HFD1_k127_4058816_12 BlaR1 peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 408.0
HFD1_k127_4058816_13 Lytic murein transglycosylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 394.0
HFD1_k127_4058816_14 LuxR family transcriptional regulator K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 381.0
HFD1_k127_4058816_15 DNA polymerase K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 357.0
HFD1_k127_4058816_16 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 340.0
HFD1_k127_4058816_17 MazG family K04765 - 3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 325.0
HFD1_k127_4058816_18 Sulfotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007653 328.0
HFD1_k127_4058816_19 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 308.0
HFD1_k127_4058816_2 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 5.401e-241 752.0
HFD1_k127_4058816_20 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 287.0
HFD1_k127_4058816_21 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001264 279.0
HFD1_k127_4058816_22 Oligoketide cyclase lipid transport protein K18588 - - 0.000000000000000000000000000000000000000000000000000000000000000000002433 241.0
HFD1_k127_4058816_23 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000002685 234.0
HFD1_k127_4058816_24 gag-polyprotein putative aspartyl protease K06985 - - 0.000000000000000000000000000000000000000000000000000000000000000002458 231.0
HFD1_k127_4058816_25 Peptidase M56 - - - 0.00000000000000000000000000000000000000000000000000000000000005642 226.0
HFD1_k127_4058816_26 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000000000000000000000009137 196.0
HFD1_k127_4058816_27 - - - - 0.000000000000000000000000000000000000000000000005497 177.0
HFD1_k127_4058816_28 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000001405 171.0
HFD1_k127_4058816_29 Penicillinase repressor - - - 0.00000000000000000000000000000000000000000000145 167.0
HFD1_k127_4058816_3 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 9.25e-240 762.0
HFD1_k127_4058816_30 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000002547 167.0
HFD1_k127_4058816_31 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000000000000000003174 142.0
HFD1_k127_4058816_32 Belongs to the CinA family K03743 - 3.5.1.42 0.0000000000000000000000000001138 124.0
HFD1_k127_4058816_33 - - - - 0.00000000000000000000000003249 114.0
HFD1_k127_4058816_34 receptor K16092 - - 0.00000000000000000005805 94.0
HFD1_k127_4058816_35 Domain of unknown function (DUF1905) - - - 0.00000000000000001983 94.0
HFD1_k127_4058816_36 - - - - 0.0000000000000001657 83.0
HFD1_k127_4058816_37 Resolvase, N terminal domain - - - 0.00000000000005541 75.0
HFD1_k127_4058816_4 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K13599 - - 2.741e-235 734.0
HFD1_k127_4058816_5 acyl-CoA dehydrogenase K00252 - 1.3.8.6 1.982e-220 688.0
HFD1_k127_4058816_6 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 579.0
HFD1_k127_4058816_7 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 576.0
HFD1_k127_4058816_8 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 544.0
HFD1_k127_4058816_9 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008192 545.0
HFD1_k127_4062203_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1804.0
HFD1_k127_4062203_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 1.851e-226 717.0
HFD1_k127_4062203_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000001238 113.0
HFD1_k127_4062203_11 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000000003972 112.0
HFD1_k127_4062203_12 - - - - 0.0000000000000000000000002827 113.0
HFD1_k127_4062203_14 Protein of unknown function (DUF3618) - - - 0.000000437 59.0
HFD1_k127_4062203_15 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000009654 59.0
HFD1_k127_4062203_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 7.696e-212 670.0
HFD1_k127_4062203_3 Belongs to the CarA family K01956 - 6.3.5.5 1.486e-198 624.0
HFD1_k127_4062203_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 578.0
HFD1_k127_4062203_5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001418 246.0
HFD1_k127_4062203_6 membrane protein (homolog of Drosophila rhomboid) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001537 245.0
HFD1_k127_4062203_7 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000000000000000003772 209.0
HFD1_k127_4062203_8 Septum formation initiator - - - 0.000000000000000000000000000000000042 136.0
HFD1_k127_4062203_9 Domain of unknown function (DUF4170) - - - 0.00000000000000000000000000004788 118.0
HFD1_k127_4066822_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 1.289e-294 924.0
HFD1_k127_4066822_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.441e-224 702.0
HFD1_k127_4066822_10 DNA polymerase III K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 292.0
HFD1_k127_4066822_11 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002378 272.0
HFD1_k127_4066822_12 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003539 261.0
HFD1_k127_4066822_13 to the N-terminal domain of Lon protease K07157 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004086 256.0
HFD1_k127_4066822_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000169 218.0
HFD1_k127_4066822_15 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000000000000001074 208.0
HFD1_k127_4066822_16 Domain of unknown function (DUF3576) - - - 0.000000000000000000000000000000000000000000000000000000001213 203.0
HFD1_k127_4066822_17 Lipopolysaccharide-assembly K03643 - - 0.0000000000000000000000000000000000000000000000000001221 196.0
HFD1_k127_4066822_18 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000000000000000000008599 186.0
HFD1_k127_4066822_19 COG1012 NAD-dependent aldehyde dehydrogenases - - - 0.00000000000000000000000000000000000005539 146.0
HFD1_k127_4066822_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.433e-209 656.0
HFD1_k127_4066822_20 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.00000000000004167 81.0
HFD1_k127_4066822_3 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 482.0
HFD1_k127_4066822_4 exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 451.0
HFD1_k127_4066822_5 Chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 403.0
HFD1_k127_4066822_6 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 394.0
HFD1_k127_4066822_7 Thioredoxin K05838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 355.0
HFD1_k127_4066822_8 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009475 341.0
HFD1_k127_4066822_9 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 303.0
HFD1_k127_4071717_0 Trypsin-like peptidase domain K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000001604 245.0
HFD1_k127_4071717_1 SpoIIAA-like - - - 0.000000000000000000000000000000000000000001893 158.0
HFD1_k127_4071717_2 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000007735 104.0
HFD1_k127_4071717_3 - - - - 0.000009893 50.0
HFD1_k127_4075312_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 1.998e-196 618.0
HFD1_k127_4075312_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000001235 220.0
HFD1_k127_4075312_2 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.00000000000000000000000000000000000005991 143.0
HFD1_k127_4075312_3 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000001167 127.0
HFD1_k127_4075656_0 Histidine kinase - - - 5.239e-273 858.0
HFD1_k127_4075656_1 ATPase or kinase K06925 - - 0.00000000000000000000000000000000000000000000000005205 186.0
HFD1_k127_4090679_0 Glycosyltransferase Family 4 K14335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 447.0
HFD1_k127_4090679_1 Uncharacterized protein conserved in bacteria (DUF2334) K06986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004754 263.0
HFD1_k127_4090679_2 Polynucleotide adenylyltransferase K00970 - 2.7.7.19 0.0000000000000000000000000001717 118.0
HFD1_k127_4105988_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.997e-248 769.0
HFD1_k127_4105988_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 506.0
HFD1_k127_4105988_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007991 415.0
HFD1_k127_4105988_3 membrane protein, TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005335 298.0
HFD1_k127_4105988_4 membrane protein, TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001288 256.0
HFD1_k127_4105988_5 membrane K08973 - - 0.0000000000000000000000000000000000000000000000000000000000000417 218.0
HFD1_k127_4105988_6 Maf-like protein K06287 - - 0.00000000000000096 80.0
HFD1_k127_4113641_0 synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 544.0
HFD1_k127_4113641_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000001586 172.0
HFD1_k127_4115303_0 Transport of potassium into the cell K03549 - - 2.974e-236 741.0
HFD1_k127_4115303_1 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 337.0
HFD1_k127_4116216_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.0 1137.0
HFD1_k127_4116216_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.471e-207 652.0
HFD1_k127_4116216_2 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 550.0
HFD1_k127_4116216_3 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006324 295.0
HFD1_k127_4116216_4 Domain of unknown function (DUF4115) - - - 0.0000000000000000000000001372 110.0
HFD1_k127_4139515_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 3.157e-212 664.0
HFD1_k127_4139515_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 504.0
HFD1_k127_4139515_2 Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008443 394.0
HFD1_k127_4139515_3 Electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 343.0
HFD1_k127_4139515_4 CarD family transcriptional regulator K07736 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009062 314.0
HFD1_k127_4139515_5 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000000000000000005385 120.0
HFD1_k127_4231701_0 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 381.0
HFD1_k127_4231701_1 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 325.0
HFD1_k127_4231701_2 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000006091 146.0
HFD1_k127_4261311_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 8.659e-272 848.0
HFD1_k127_4261311_1 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 428.0
HFD1_k127_4261311_10 Belongs to the BolA IbaG family K05527 - - 0.0000000000000000000000000000009029 126.0
HFD1_k127_4261311_2 enzyme related to lactoylglutathione lyase K06996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 306.0
HFD1_k127_4261311_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007092 287.0
HFD1_k127_4261311_4 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002046 279.0
HFD1_k127_4261311_5 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001053 268.0
HFD1_k127_4261311_6 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004829 254.0
HFD1_k127_4261311_7 molecular chaperone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004638 250.0
HFD1_k127_4261311_8 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000000000000000000000000004091 231.0
HFD1_k127_4261311_9 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000054 212.0
HFD1_k127_4270766_0 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 3.035e-320 1014.0
HFD1_k127_4270766_1 helicase K16899 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 336.0
HFD1_k127_4294616_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 3.641e-195 623.0
HFD1_k127_4294616_1 IS66 Orf2 like protein K07484 - - 0.0000000000000000000000000000000000000000000000275 178.0
HFD1_k127_4294616_2 Transposase K07483 - - 0.00000000000002199 79.0
HFD1_k127_430070_0 ATP-dependent DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 426.0
HFD1_k127_430070_1 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003496 276.0
HFD1_k127_430070_2 response regulator K11443 - - 0.000000000000000000000000000000000000000000006119 167.0
HFD1_k127_430070_3 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000000000000001594 106.0
HFD1_k127_430070_4 Protein of unknown function (DUF3572) - - - 0.00000000000000000001406 93.0
HFD1_k127_4315786_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1135.0
HFD1_k127_4315786_1 GGDEF domain - - - 1.739e-251 787.0
HFD1_k127_4347864_0 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 7.821e-208 657.0
HFD1_k127_4347864_1 Dimethylmenaquinone methyltransferase K10218 - 4.1.3.17 0.0000000000000001558 85.0
HFD1_k127_4357067_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 587.0
HFD1_k127_4357067_1 Protein of unknown function (DUF3089) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 459.0
HFD1_k127_4357067_10 Belongs to the ompA family K03640 - - 0.000000000000000000242 98.0
HFD1_k127_4357067_11 - - - - 0.00000000000436 72.0
HFD1_k127_4357067_2 involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 410.0
HFD1_k127_4357067_3 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 412.0
HFD1_k127_4357067_4 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 346.0
HFD1_k127_4357067_5 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009794 310.0
HFD1_k127_4357067_6 phosphomannomutase K01840 - 5.4.2.8 0.00000000000000000000000000000000000000000000000000000001091 200.0
HFD1_k127_4357067_7 thioesterase K07107 - - 0.000000000000000000000000000000000000000000000000001636 188.0
HFD1_k127_4357067_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000001473 177.0
HFD1_k127_4357067_9 FOG TPR repeat, SEL1 subfamily K07126 - - 0.000000000000000000000000000000000000000001574 158.0
HFD1_k127_4360847_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.503e-213 665.0
HFD1_k127_4360847_1 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000000000009263 218.0
HFD1_k127_4360847_2 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.0000000000000000000000031 102.0
HFD1_k127_4412001_0 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 509.0
HFD1_k127_4412001_1 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009309 495.0
HFD1_k127_4412001_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 349.0
HFD1_k127_4412001_3 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002575 274.0
HFD1_k127_4412001_4 Protein-disulfide isomerase - - - 0.0000000000000000000000000000000000461 136.0
HFD1_k127_4449196_0 Prolyl oligopeptidase family - - - 2.522e-293 915.0
HFD1_k127_4449196_1 Peptidase, M28 - - - 8.705e-197 623.0
HFD1_k127_4449196_2 Belongs to the ClpA ClpB family K03694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 433.0
HFD1_k127_4449196_3 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000007644 213.0
HFD1_k127_4449196_4 transcriptional regulator - - - 0.00000000000000000000000000000002045 134.0
HFD1_k127_4449196_5 - - - - 0.000000000000000000000000000000267 126.0
HFD1_k127_4449196_6 Predicted membrane protein (DUF2231) - - - 0.000000000000000004854 94.0
HFD1_k127_4483091_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 488.0
HFD1_k127_4483091_1 of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 447.0
HFD1_k127_4596949_0 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 391.0
HFD1_k127_4596949_1 PFAM CRISPR-associated protein Cse1 (CRISPR_cse1) K19123 - - 0.0000000000000006994 80.0
HFD1_k127_4597560_0 Transketolase, thiamine diphosphate binding domain K00163 - 1.2.4.1 1.648e-308 953.0
HFD1_k127_4597560_1 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 319.0
HFD1_k127_4597560_2 dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000863 224.0
HFD1_k127_4678765_0 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 3.796e-197 629.0
HFD1_k127_4678765_1 beta-lactamase K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 426.0
HFD1_k127_4678765_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 342.0
HFD1_k127_4678765_3 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 321.0
HFD1_k127_4678765_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004462 261.0
HFD1_k127_4678765_5 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000007088 186.0
HFD1_k127_4678765_6 - - - - 0.000009003 53.0
HFD1_k127_4684532_0 PFAM transposase, IS204 IS1001 IS1096 IS1165 family protein - - - 5.169e-195 621.0
HFD1_k127_4684532_1 Winged helix-turn helix - - - 0.000000000405 62.0
HFD1_k127_4700924_0 protein conserved in bacteria K09919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 385.0
HFD1_k127_4700924_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 341.0
HFD1_k127_4700924_2 endoribonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000002069 227.0
HFD1_k127_471250_0 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001178 253.0
HFD1_k127_471250_1 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000002408 173.0
HFD1_k127_471250_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.0000000000000000000000000000000000000002327 150.0
HFD1_k127_471250_3 Branched-chain amino acid aminotransferase - - - 0.0000000000000000000000000000000000000005337 151.0
HFD1_k127_471250_4 Short repeat of unknown function (DUF308) - - - 0.000000001173 66.0
HFD1_k127_4848363_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1134.0
HFD1_k127_4848363_1 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 338.0
HFD1_k127_4848363_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 288.0
HFD1_k127_4848363_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000002748 259.0
HFD1_k127_4848363_4 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000009754 242.0
HFD1_k127_4848363_5 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000223 131.0
HFD1_k127_4868627_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 2542.0
HFD1_k127_4868627_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 8.411e-235 731.0
HFD1_k127_4868627_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000002588 81.0
HFD1_k127_4893032_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 1.382e-231 725.0
HFD1_k127_4893032_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 8.988e-217 684.0
HFD1_k127_4893032_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 605.0
HFD1_k127_4893032_3 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 585.0
HFD1_k127_4893032_4 Cell division protein FtsI penicillin-binding protein K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 544.0
HFD1_k127_4893032_5 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 542.0
HFD1_k127_4893032_6 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 539.0
HFD1_k127_4893032_7 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 535.0
HFD1_k127_4893032_8 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 453.0
HFD1_k127_4893032_9 Cell wall formation K01921 - 6.3.2.4 0.000000000000000000000000000000000002155 140.0
HFD1_k127_4909723_0 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 477.0
HFD1_k127_4909723_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000000001241 211.0
HFD1_k127_4909723_2 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000006704 192.0
HFD1_k127_4909723_3 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000002539 179.0
HFD1_k127_4909723_4 PFAM peptidase M16 domain protein - - - 0.000000000000000000000000000000000000000000001766 169.0
HFD1_k127_4909723_5 Belongs to the 'phage' integrase family - - - 0.00000000000001192 74.0
HFD1_k127_4909723_6 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000000009089 69.0
HFD1_k127_4913042_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.143e-281 874.0
HFD1_k127_4913042_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 9.051e-214 675.0
HFD1_k127_4913042_10 Sporulation related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004284 237.0
HFD1_k127_4913042_11 Sporulation related domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004527 235.0
HFD1_k127_4913042_12 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.0000000000000000000000000000004651 125.0
HFD1_k127_4913042_13 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000004049 106.0
HFD1_k127_4913042_14 protein secretion K03116 - - 0.000000000000000000004778 96.0
HFD1_k127_4913042_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 601.0
HFD1_k127_4913042_3 dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 551.0
HFD1_k127_4913042_4 Cell wall formation K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 449.0
HFD1_k127_4913042_5 beta-N-acetylhexosaminidase K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 421.0
HFD1_k127_4913042_6 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 383.0
HFD1_k127_4913042_7 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 349.0
HFD1_k127_4913042_8 Cell division protein FtsQ K03589 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 331.0
HFD1_k127_4913042_9 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 293.0
HFD1_k127_4938968_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 3.994e-203 644.0
HFD1_k127_4938968_1 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 447.0
HFD1_k127_4938968_2 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 347.0
HFD1_k127_4938968_3 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000000000857 245.0
HFD1_k127_4938968_4 DNA polymerase III K02339 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000002184 208.0
HFD1_k127_4957479_0 Aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 586.0
HFD1_k127_4957479_1 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008838 396.0
HFD1_k127_4957479_2 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000004918 202.0
HFD1_k127_4957479_3 SnoaL-like domain - - - 0.000000000000001787 83.0
HFD1_k127_4957479_4 YCII-related domain - - - 0.0000000000002508 75.0
HFD1_k127_5003035_0 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009163 414.0
HFD1_k127_5003035_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 368.0
HFD1_k127_5003035_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 346.0
HFD1_k127_5003035_3 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 330.0
HFD1_k127_5003035_4 phosphoserine phosphatase K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 289.0
HFD1_k127_5003035_5 FOG TPR repeat, SEL1 subfamily K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000001382 239.0
HFD1_k127_5003035_6 Sporulation related domain - - - 0.000000000000000000000000000000000000000000000000000000000000002107 231.0
HFD1_k127_5003035_7 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000004909 200.0
HFD1_k127_5003035_8 - - - - 0.00000000000000000000000000000000000000000002251 172.0
HFD1_k127_5003035_9 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000000000000000772 160.0
HFD1_k127_5012563_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.0 1102.0
HFD1_k127_5012563_1 PFAM Aminotransferase class I and II K00832 - 2.6.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 529.0
HFD1_k127_5012563_2 Oxidoreductase FAD-binding domain K00523,K02613 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 503.0
HFD1_k127_5012563_3 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 358.0
HFD1_k127_5012563_4 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 300.0
HFD1_k127_5012563_5 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000001009 248.0
HFD1_k127_5012563_6 Phenylacetic acid degradation B K02610 - - 0.000000000000000000000000000000000000000000000001654 174.0
HFD1_k127_5085861_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1399.0
HFD1_k127_5085861_1 COG1505 Serine proteases of the peptidase family S9A K01322 - 3.4.21.26 0.0 1067.0
HFD1_k127_5085861_10 Galactose 1-dehydrogenase K00035 - 1.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008695 427.0
HFD1_k127_5085861_11 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 420.0
HFD1_k127_5085861_12 Arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 386.0
HFD1_k127_5085861_13 Gluconolactonase K14274 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 362.0
HFD1_k127_5085861_14 protein conserved in bacteria K09781 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007681 329.0
HFD1_k127_5085861_15 COG4313 Protein involved in meta-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005049 312.0
HFD1_k127_5085861_16 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 310.0
HFD1_k127_5085861_17 Phenylalanine-4-hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001652 282.0
HFD1_k127_5085861_18 Aldolase K01631 - 4.1.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000001393 268.0
HFD1_k127_5085861_19 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001041 261.0
HFD1_k127_5085861_2 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.0 998.0
HFD1_k127_5085861_20 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001882 246.0
HFD1_k127_5085861_21 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003471 228.0
HFD1_k127_5085861_22 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000001184 207.0
HFD1_k127_5085861_23 Iron-sulfur cluster assembly protein K02612 - - 0.00000000000000000000000000000000000000000000000000000003033 201.0
HFD1_k127_5085861_24 SOS response - - - 0.000000000000000000000000000000000000000000000000009263 188.0
HFD1_k127_5085861_25 Protein of unknown function (DUF1272) K09984 - - 0.0000000000000000000000000000000000000000000191 164.0
HFD1_k127_5085861_26 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000002015 115.0
HFD1_k127_5085861_27 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000001418 102.0
HFD1_k127_5085861_28 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000001685 70.0
HFD1_k127_5085861_29 - - - - 0.0003354 48.0
HFD1_k127_5085861_3 Glycosyl hydrolase family 1 - - - 2.924e-233 726.0
HFD1_k127_5085861_4 Histidine K01745 - 4.3.1.3 1.646e-221 709.0
HFD1_k127_5085861_5 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 2.969e-202 638.0
HFD1_k127_5085861_6 mandelate racemase muconate lactonizing K01684,K01781,K08323 - 4.2.1.6,4.2.1.8,5.1.2.2 5.095e-200 628.0
HFD1_k127_5085861_7 Belongs to the thiolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 609.0
HFD1_k127_5085861_8 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 550.0
HFD1_k127_5085861_9 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 494.0
HFD1_k127_5110771_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1358.0
HFD1_k127_5110771_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 1.644e-313 975.0
HFD1_k127_5110771_10 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 336.0
HFD1_k127_5110771_11 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 334.0
HFD1_k127_5110771_12 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 294.0
HFD1_k127_5110771_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006006 268.0
HFD1_k127_5110771_14 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001434 258.0
HFD1_k127_5110771_15 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001752 263.0
HFD1_k127_5110771_16 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000000000000000000000000001189 253.0
HFD1_k127_5110771_17 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000008842 143.0
HFD1_k127_5110771_18 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000001855 72.0
HFD1_k127_5110771_19 Transcriptional regulatory protein, C terminal - - - 0.0002817 44.0
HFD1_k127_5110771_2 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 3.681e-239 743.0
HFD1_k127_5110771_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 1.654e-225 713.0
HFD1_k127_5110771_4 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006253 451.0
HFD1_k127_5110771_5 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 447.0
HFD1_k127_5110771_6 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 444.0
HFD1_k127_5110771_7 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 398.0
HFD1_k127_5110771_8 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006748 360.0
HFD1_k127_5110771_9 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 362.0
HFD1_k127_5129265_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 317.0
HFD1_k127_5129265_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 304.0
HFD1_k127_5129265_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000001318 183.0
HFD1_k127_5129265_3 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000005868 157.0
HFD1_k127_5129265_5 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.0000002148 59.0
HFD1_k127_5172896_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 485.0
HFD1_k127_5172896_1 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005391 476.0
HFD1_k127_5172896_2 MAPEG family - - - 0.0000000000000000000000000000000000000002844 154.0
HFD1_k127_5262111_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 489.0
HFD1_k127_5262111_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 376.0
HFD1_k127_5262111_2 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000000000006279 181.0
HFD1_k127_5262111_3 cytochrome C K02198 - - 0.0000000006523 62.0
HFD1_k127_5262111_4 Histidine triad (HIT) protein - - - 0.00000002141 57.0
HFD1_k127_5284888_0 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase K06147 - - 2.371e-259 813.0
HFD1_k127_5284888_1 Dipeptidyl carboxypeptidase K01284 - 3.4.15.5 2.205e-203 650.0
HFD1_k127_5284888_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008883 464.0
HFD1_k127_5284888_3 gag-polyprotein putative aspartyl protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 340.0
HFD1_k127_5284888_4 Peroxiredoxin - - - 0.000000000000000000000000000000000000000000000000000006573 194.0
HFD1_k127_5284888_5 Protein of unknown function (DUF1810) - - - 0.0000000000000000000000000000000000000000000003137 171.0
HFD1_k127_5288070_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005134 503.0
HFD1_k127_5288070_1 enoyl-CoA hydratase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 497.0
HFD1_k127_5288070_2 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009209 427.0
HFD1_k127_5288070_3 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 406.0
HFD1_k127_5288070_4 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000002914 227.0
HFD1_k127_5288070_5 COG0694 Thioredoxin-like proteins and domains - - - 0.00000000000000000000000000000000000004037 145.0
HFD1_k127_5288070_6 Cytochrome C' - - - 0.00000000000000000000000002473 115.0
HFD1_k127_5323882_0 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 467.0
HFD1_k127_5323882_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 346.0
HFD1_k127_5388112_0 5-methyltetrahydrofolate--homocysteine methyltransferase K00548 - 2.1.1.13 1.559e-281 874.0
HFD1_k127_5388112_1 Thiol disulfide interchange protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000525 261.0
HFD1_k127_5393433_0 Peptidase, M28 - - - 2.372e-200 633.0
HFD1_k127_5393433_1 DNA repair photolyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 572.0
HFD1_k127_5393433_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000004886 48.0
HFD1_k127_542382_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 9.017e-246 771.0
HFD1_k127_542382_1 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 585.0
HFD1_k127_542382_2 COG4618 ABC-type protease lipase transport system, ATPase and permease components K06148,K12536,K16299 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 548.0
HFD1_k127_542382_3 TIGRFAM type I secretion membrane fusion protein, HlyD family K02022 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 436.0
HFD1_k127_542382_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 357.0
HFD1_k127_542382_5 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 300.0
HFD1_k127_542382_6 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000002759 226.0
HFD1_k127_542382_7 Cache domain - - - 0.00000000000000000000000000000000000000000000000000003532 196.0
HFD1_k127_542382_8 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000003387 184.0
HFD1_k127_542382_9 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00000000000000000000000000000000000000000001923 163.0
HFD1_k127_5513245_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1095.0
HFD1_k127_5513245_1 Belongs to the serpin family K13963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009725 310.0
HFD1_k127_5513245_2 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.000000000000000000000000000000000000000000000000000000000003272 214.0
HFD1_k127_5513245_3 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000007953 98.0
HFD1_k127_5578638_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 2.256e-211 670.0
HFD1_k127_5578638_1 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 499.0
HFD1_k127_5578638_10 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000000000002958 194.0
HFD1_k127_5578638_11 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000000000000000000000000000000000000000001616 180.0
HFD1_k127_5578638_12 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000004507 160.0
HFD1_k127_5578638_13 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000000000000747 134.0
HFD1_k127_5578638_14 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000000000000004226 118.0
HFD1_k127_5578638_15 - - - - 0.0000000000000000000000001343 110.0
HFD1_k127_5578638_16 Protein of unknown function (DUF2842) - - - 0.0000000000000000005264 89.0
HFD1_k127_5578638_18 heat shock protein binding K03686,K04082 - - 0.000003198 58.0
HFD1_k127_5578638_2 ATPase with chaperone activity K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 482.0
HFD1_k127_5578638_3 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 466.0
HFD1_k127_5578638_4 Belongs to the transketolase family K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 392.0
HFD1_k127_5578638_5 ATPase with chaperone activity K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008598 347.0
HFD1_k127_5578638_6 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 325.0
HFD1_k127_5578638_7 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 306.0
HFD1_k127_5578638_8 Cell Wall Hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000282 289.0
HFD1_k127_5578638_9 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000001944 219.0
HFD1_k127_5590566_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1145.0
HFD1_k127_5590566_1 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009003 303.0
HFD1_k127_5590566_2 2OG-Fe(II) oxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001982 264.0
HFD1_k127_5590566_3 Putative 2OG-Fe(II) oxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000003883 232.0
HFD1_k127_5627102_0 DNA polymerase K02337 - 2.7.7.7 0.0 1020.0
HFD1_k127_5627102_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 6.962e-239 743.0
HFD1_k127_5627102_2 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 596.0
HFD1_k127_5627102_3 cystathionine beta-lyase K01760 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 445.0
HFD1_k127_5627102_4 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 342.0
HFD1_k127_5627102_5 Transport of potassium into the cell K03549 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003217 263.0
HFD1_k127_5627102_6 2'-5' RNA ligase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000002632 209.0
HFD1_k127_5627102_7 Protein of unknown function (DUF3775) - - - 0.000000000000000000000000000000000000000000000000000005798 194.0
HFD1_k127_5628029_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1219.0
HFD1_k127_5628029_1 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 434.0
HFD1_k127_5628029_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 422.0
HFD1_k127_5628029_3 PFAM peptidase M16 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009282 269.0
HFD1_k127_5628029_4 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.000000000000000000000000000000000000000000000000000000000003165 217.0
HFD1_k127_5628029_5 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03767 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000298 203.0
HFD1_k127_5628029_6 SURF1-like protein K14998 - - 0.000000000000000000000000000000000000000000000000002954 188.0
HFD1_k127_5628029_7 Protein of unknown function (DUF983) - - - 0.000000000000000000000000000000000000000001461 161.0
HFD1_k127_5636023_0 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 595.0
HFD1_k127_5636023_1 AFG1 family ATPase K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 523.0
HFD1_k127_5636023_2 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 517.0
HFD1_k127_5636023_3 protein, possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000000000000000000000000000001141 229.0
HFD1_k127_5636023_4 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000002381 130.0
HFD1_k127_5653187_0 - - - - 0.0000000000000000000000000000000000000000000000000000006109 196.0
HFD1_k127_5653187_1 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000001309 177.0
HFD1_k127_5653187_2 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000000000019 138.0
HFD1_k127_5667233_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 2.921e-220 694.0
HFD1_k127_5667233_1 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007338 437.0
HFD1_k127_5667233_2 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001138 248.0
HFD1_k127_5683112_0 methyl-accepting chemotaxis protein K03406 - - 4.118e-214 674.0
HFD1_k127_5683112_1 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006088 557.0
HFD1_k127_5683112_2 - K18546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 374.0
HFD1_k127_5683112_3 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001426 257.0
HFD1_k127_5683112_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000921 237.0
HFD1_k127_5683112_5 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000000000000000000000000001507 208.0
HFD1_k127_5683112_6 - K03832 - - 0.000000000000000000000001647 104.0
HFD1_k127_5683112_7 PspC domain protein - - - 0.000000000000001032 83.0
HFD1_k127_5699767_0 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 467.0
HFD1_k127_5699767_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 464.0
HFD1_k127_5699767_2 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003331 348.0
HFD1_k127_5699767_3 MobA-like NTP transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001129 263.0
HFD1_k127_5699767_4 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000007863 153.0
HFD1_k127_5703479_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0 1082.0
HFD1_k127_5703479_1 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000074 481.0
HFD1_k127_5703479_2 NAD(P)H-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000005149 215.0
HFD1_k127_5703479_3 DoxX K15977 - - 0.0000000000000000000000000000000000000007293 152.0
HFD1_k127_5703479_4 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000002253 143.0
HFD1_k127_5705785_0 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007774 451.0
HFD1_k127_5705785_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 337.0
HFD1_k127_5705785_2 Flavinator of succinate dehydrogenase K09159 - - 0.0000000000000000000000000000000004442 132.0
HFD1_k127_5729320_0 Oxidoreductase - - - 2.678e-275 854.0
HFD1_k127_5729320_1 Toxic anion resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 593.0
HFD1_k127_5729320_2 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 460.0
HFD1_k127_5729320_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003768 248.0
HFD1_k127_5729320_4 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000000000000000000000000000003847 192.0
HFD1_k127_5729320_5 - - - - 0.00000000000000000000000000000000000001107 153.0
HFD1_k127_5729320_6 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000002774 139.0
HFD1_k127_5729320_7 Histidine kinase - - - 0.00002577 57.0
HFD1_k127_5755115_0 synthetase K01897 - 6.2.1.3 1.641e-269 839.0
HFD1_k127_5755115_1 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 4.353e-241 757.0
HFD1_k127_5755115_10 Aldo/keto reductase family - - - 0.00000001392 55.0
HFD1_k127_5755115_2 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 467.0
HFD1_k127_5755115_3 Protein of unknown function (DUF541) K09797 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 314.0
HFD1_k127_5755115_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 297.0
HFD1_k127_5755115_5 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001071 263.0
HFD1_k127_5755115_6 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000001274 165.0
HFD1_k127_5755115_7 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 0.000000000000000000000000000000000000003603 154.0
HFD1_k127_5755115_8 - - - - 0.0000000000000000000001661 102.0
HFD1_k127_5755115_9 Tetratricopeptide repeat - - - 0.0000000000000000000006006 104.0
HFD1_k127_5777924_0 Aerobic cobaltochelatase subunit CobS K09882 - 6.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 607.0
HFD1_k127_5777924_1 COG2931 RTX toxins and related Ca2 -binding proteins K01406 - 3.4.24.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 445.0
HFD1_k127_5777924_2 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001224 271.0
HFD1_k127_5777924_3 Lactoylglutathione lyase K07032 - - 0.0000000000000000000000000000000000000000000000000001137 190.0
HFD1_k127_5777924_4 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) K09883 - 6.6.1.2 0.0000000000000000000000000006391 116.0
HFD1_k127_5779387_0 nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000002629 211.0
HFD1_k127_5779387_1 Transcriptional regulator K07979 - - 0.0000000000000000000000000000000000000000000000005641 177.0
HFD1_k127_5779387_2 amino acid peptide transporter K03305 - - 0.00000000000000000000000000000000000000007413 151.0
HFD1_k127_5779387_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000001984 76.0
HFD1_k127_5787020_0 aminopeptidase N K01256 - 3.4.11.2 0.0 1135.0
HFD1_k127_5787020_1 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 429.0
HFD1_k127_5787020_2 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 327.0
HFD1_k127_5787020_3 transport system auxiliary component K18480 - - 0.0000000000000000000000000000000000000000000000000000002626 201.0
HFD1_k127_5787020_4 DnaK suppressor protein - - - 0.000000000000000000000000000000000003881 147.0
HFD1_k127_5787020_5 Cupin domain - - - 0.000000000000000000000000000000001777 134.0
HFD1_k127_5787020_6 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.00000000000000000000000000000149 123.0
HFD1_k127_5787020_7 - - - - 0.00000000000006544 74.0
HFD1_k127_5817074_0 chemotaxis K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 385.0
HFD1_k127_5817074_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000002158 135.0
HFD1_k127_5822118_0 GTP-binding protein TypA K06207 - - 1.266e-310 961.0
HFD1_k127_5822118_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000003308 134.0
HFD1_k127_5822118_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000005512 117.0
HFD1_k127_5822118_3 EVE domain - - - 0.00000000000000000000008322 99.0
HFD1_k127_5822118_4 Plasmid stabilization - - - 0.000000000000000000001488 95.0
HFD1_k127_5822118_5 Protein of unknown function (DUF3828) - - - 0.000000000000004326 83.0
HFD1_k127_5822118_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.000004384 54.0
HFD1_k127_5898802_0 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 604.0
HFD1_k127_5898802_1 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000004738 250.0
HFD1_k127_5898802_2 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000003707 194.0
HFD1_k127_5898802_3 Aminoacyl-tRNA editing domain - - - 0.000000000000000000000000000000000000000000000000000004137 197.0
HFD1_k127_5984717_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 8.267e-214 680.0
HFD1_k127_5984717_1 D-amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 473.0
HFD1_k127_5984717_2 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 301.0
HFD1_k127_5984717_3 Protein of unknown function (DUF2459) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001426 257.0
HFD1_k127_5984717_4 Protein of unknown function (DUF1211) - - - 0.0000000000000000000000000000000000000000000000000000000001957 209.0
HFD1_k127_5984717_5 secretion activating protein - - - 0.00000000000000000000000000000000000000000000000206 174.0
HFD1_k127_604146_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1772.0
HFD1_k127_604146_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 2.346e-240 760.0
HFD1_k127_604146_10 2-dehydropantoate 2-reductase K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 320.0
HFD1_k127_604146_11 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003858 275.0
HFD1_k127_604146_12 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000005855 255.0
HFD1_k127_604146_13 - - - - 0.000000000000000000000000000000000000000000000000000000000004744 211.0
HFD1_k127_604146_14 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000002181 177.0
HFD1_k127_604146_15 protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis - - - 0.000000000000000000000001658 110.0
HFD1_k127_604146_16 Domain of unknown function (DUF4440) - - - 0.0000003397 57.0
HFD1_k127_604146_2 Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine K01761 - 4.4.1.11 1.973e-224 701.0
HFD1_k127_604146_3 Fumarylacetoacetase K01555 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 576.0
HFD1_k127_604146_4 aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 547.0
HFD1_k127_604146_5 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007788 449.0
HFD1_k127_604146_6 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 454.0
HFD1_k127_604146_7 Acetoacetyl-CoA reductase K00023 - 1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 419.0
HFD1_k127_604146_8 Putative S-adenosyl-L-methionine-dependent methyltransferase K18164 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 386.0
HFD1_k127_604146_9 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 351.0
HFD1_k127_6056574_0 poly(R)-hydroxyalkanoic acid synthase K03821 - - 3.949e-277 863.0
HFD1_k127_6056574_1 Aminotransferase K14261 - - 2.796e-209 658.0
HFD1_k127_6056574_10 Domain of unknown function (DUF4893) - - - 0.0000000000000000000002181 101.0
HFD1_k127_6056574_2 UPF0126 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 316.0
HFD1_k127_6056574_3 RarD protein K05786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 323.0
HFD1_k127_6056574_4 PFAM peptidase S9 prolyl oligopeptidase active site domain protein K01322,K01354 - 3.4.21.26,3.4.21.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000006023 265.0
HFD1_k127_6056574_5 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000000000000000004191 199.0
HFD1_k127_6056574_6 Polyketide cyclase / dehydrase and lipid transport K18588 - - 0.00000000000000000000000000000008562 130.0
HFD1_k127_6056574_7 -acetyltransferase K03826,K03827,K18816 - 2.3.1.82 0.0000000000000000000000000005946 119.0
HFD1_k127_6056574_9 membrane - - - 0.000000000000000000000002283 105.0
HFD1_k127_6113918_0 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 342.0
HFD1_k127_6122109_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 419.0
HFD1_k127_6122109_1 Histidine-specific methyltransferase, SAM-dependent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 344.0
HFD1_k127_6122109_2 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009762 264.0
HFD1_k127_6122109_3 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007392 258.0
HFD1_k127_6122109_4 - - - - 0.00000000000000000000000000000000000000000007643 167.0
HFD1_k127_6122109_5 integral membrane protein K02221 - - 0.0000000000000000000000004689 107.0
HFD1_k127_6229771_0 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 479.0
HFD1_k127_6229771_1 PFAM Rh family protein ammonium transporter K03320 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015291,GO:0015292,GO:0015669,GO:0015670,GO:0015696,GO:0015893,GO:0016020,GO:0016021,GO:0019755,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008086 473.0
HFD1_k127_6229771_2 ATP dependent DNA ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 443.0
HFD1_k127_6229771_3 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000005038 230.0
HFD1_k127_6229771_4 Bacteriophage replication gene A protein (GPA) - - - 0.000000000001504 68.0
HFD1_k127_6229771_5 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.00000001656 56.0
HFD1_k127_6279154_0 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007406 284.0
HFD1_k127_6279154_1 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008236 271.0
HFD1_k127_6279154_2 Phasin protein - - - 0.000000000000000000000000000000000001257 148.0
HFD1_k127_6288990_0 NADH-quinone oxidoreductase K00336 - 1.6.5.3 0.0 1087.0
HFD1_k127_6288990_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.588e-258 803.0
HFD1_k127_6288990_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 587.0
HFD1_k127_6288990_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 313.0
HFD1_k127_6288990_4 NADH dehydrogenase K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 282.0
HFD1_k127_6288990_5 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000002674 244.0
HFD1_k127_6428909_0 GMC oxidoreductase - - - 2.099e-236 741.0
HFD1_k127_6435806_0 of ABC transporters with duplicated ATPase K15738 - - 1.871e-294 912.0
HFD1_k127_6435806_1 protein conserved in bacteria - - - 7.417e-280 872.0
HFD1_k127_6435806_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 6.834e-224 713.0
HFD1_k127_6435806_3 peptidase M13 - - - 2.675e-223 699.0
HFD1_k127_6435806_4 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 4.363e-218 684.0
HFD1_k127_6435806_5 Histidine kinase - - - 6.81e-198 626.0
HFD1_k127_6435806_6 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 496.0
HFD1_k127_6435806_7 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 422.0
HFD1_k127_6435806_8 - - - - 0.0000000000000000000001523 100.0
HFD1_k127_6447590_0 Malic enzyme K00029 - 1.1.1.40 0.0 1177.0
HFD1_k127_6447590_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 377.0
HFD1_k127_6447590_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 368.0
HFD1_k127_6461920_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.09e-207 664.0
HFD1_k127_6461920_1 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 464.0
HFD1_k127_6461920_2 Protease prsW family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000734 316.0
HFD1_k127_6461920_3 Protein of unknown function (DUF1223) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 295.0
HFD1_k127_6481741_0 Amidohydrolase family - - - 9.156e-215 689.0
HFD1_k127_6481741_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 355.0
HFD1_k127_6481741_10 - - - - 0.000000000000000000000000000000000000000001706 166.0
HFD1_k127_6481741_11 PFAM SWIB MDM2 domain - - - 0.000000000000000000000000000003555 124.0
HFD1_k127_6481741_2 proteins, homologs of microcin C7 resistance protein MccF K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 309.0
HFD1_k127_6481741_3 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 304.0
HFD1_k127_6481741_4 Methanol dehydrogenase K06872 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001439 269.0
HFD1_k127_6481741_5 Belongs to the NadC ModD family - - - 0.0000000000000000000000000000000000000000000000000000000000000001561 224.0
HFD1_k127_6481741_6 membrane K08988 - - 0.00000000000000000000000000000000000000000000000000000000000007642 225.0
HFD1_k127_6481741_7 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000000000000000000000000005797 214.0
HFD1_k127_6481741_8 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000000000000000000000000000001324 201.0
HFD1_k127_6481741_9 Nudix hydrolase K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000296 201.0
HFD1_k127_6541769_0 Belongs to the DEAD box helicase family - - - 3.278e-195 617.0
HFD1_k127_6541769_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 603.0
HFD1_k127_6541769_2 Glutathione S-transferase K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 475.0
HFD1_k127_6541769_3 PFAM SapC family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 370.0
HFD1_k127_6541769_4 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003 268.0
HFD1_k127_6541769_5 response regulator K13589 - - 0.00000000000000000000000000000000000000000000000000000000000000005783 225.0
HFD1_k127_6541769_6 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000003027 212.0
HFD1_k127_6541769_7 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000002031 172.0
HFD1_k127_6541769_8 - - - - 0.0000000000000000000000000000000008868 134.0
HFD1_k127_6557784_0 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000001133 223.0
HFD1_k127_6557784_1 EVE domain - - - 0.000000000000000000000000000000000000000000000000009866 183.0
HFD1_k127_6557784_2 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000001093 170.0
HFD1_k127_6557784_3 COG3773 Cell wall hydrolyses involved in spore germination K01449 - 3.5.1.28 0.000000000000000000000000000000000000000000002125 174.0
HFD1_k127_6557784_4 Protein of unknown function (DUF3828) - - - 0.00000000001467 71.0
HFD1_k127_6567613_0 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005434 529.0
HFD1_k127_6567613_1 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 462.0
HFD1_k127_6567613_2 Branched-chain amino acid aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006432 324.0
HFD1_k127_6567613_3 cation diffusion facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 316.0
HFD1_k127_6575726_0 isomerase K01809 - 5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000001577 240.0
HFD1_k127_6575726_1 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000003096 207.0
HFD1_k127_6575726_2 Thioredoxin-like - - - 0.000000000000000000000000000002049 127.0
HFD1_k127_6580797_0 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 560.0
HFD1_k127_6602280_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 5.692e-265 821.0
HFD1_k127_6602280_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 4.976e-217 679.0
HFD1_k127_6602280_2 Alkaline phosphatase with broad substrate specificity K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 582.0
HFD1_k127_6602280_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008699 342.0
HFD1_k127_6602280_4 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 331.0
HFD1_k127_6620798_0 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 1.334e-206 649.0
HFD1_k127_6620798_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 572.0
HFD1_k127_6620798_2 Belongs to the transketolase family K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 481.0
HFD1_k127_6620798_3 Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 459.0
HFD1_k127_6620798_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 312.0
HFD1_k127_6620798_5 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000003826 239.0
HFD1_k127_6620798_6 Prolyl 4-hydroxylase alpha subunit homologues. K00472 - 1.14.11.2 0.00000000000000000000000000000000000000000000000000000000000003237 221.0
HFD1_k127_6620798_7 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000008201 181.0
HFD1_k127_6672671_0 Transposase, Mutator family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 358.0
HFD1_k127_6672877_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 2.013e-222 694.0
HFD1_k127_6672877_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 613.0
HFD1_k127_6672877_10 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009427 241.0
HFD1_k127_6672877_11 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000005377 231.0
HFD1_k127_6672877_12 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000000000000000000000001089 230.0
HFD1_k127_6672877_13 dioxygenase of extradiol dioxygenase family K06991 - - 0.000000000000000000000000000000000000000000000000000000000000002754 219.0
HFD1_k127_6672877_14 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000005317 219.0
HFD1_k127_6672877_15 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000000000000000000000000000612 203.0
HFD1_k127_6672877_16 peptidase M22 - - - 0.000000000000000000000000000000000000000000000000000005125 196.0
HFD1_k127_6672877_17 Acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000002693 198.0
HFD1_k127_6672877_18 Acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000632 168.0
HFD1_k127_6672877_19 Predicted membrane protein (DUF2231) - - - 0.0000000000000000000000000000000000001003 148.0
HFD1_k127_6672877_2 glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009114 602.0
HFD1_k127_6672877_20 Predicted membrane protein (DUF2231) - - - 0.000000000000000000000007615 108.0
HFD1_k127_6672877_21 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000002608 94.0
HFD1_k127_6672877_3 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 543.0
HFD1_k127_6672877_4 Phosphate starvation-inducible protein PhoH K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 502.0
HFD1_k127_6672877_5 Chalcone and stilbene synthases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 457.0
HFD1_k127_6672877_6 glucose sorbosone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 433.0
HFD1_k127_6672877_7 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 390.0
HFD1_k127_6672877_8 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 393.0
HFD1_k127_6672877_9 Domain of Unknown Function (DUF1259) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005036 375.0
HFD1_k127_6727279_0 Methylmalonate-semialdehyde dehydrogenase K00140 - 1.2.1.18,1.2.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 475.0
HFD1_k127_6727279_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006067 434.0
HFD1_k127_6727279_2 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000001119 208.0
HFD1_k127_6727279_3 - - - - 0.0000000000000000000009599 100.0
HFD1_k127_6731560_0 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 504.0
HFD1_k127_6731560_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 332.0
HFD1_k127_6731560_2 GtrA-like protein - - - 0.00000000000000000000000000000000000000000004504 164.0
HFD1_k127_6747138_0 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007938 301.0
HFD1_k127_6747138_1 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009537 296.0
HFD1_k127_6747138_2 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000008797 184.0
HFD1_k127_67726_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008188 501.0
HFD1_k127_67726_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 312.0
HFD1_k127_67726_2 - - - - 0.0000000000000000000000000000002798 128.0
HFD1_k127_6776267_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 3.79e-293 913.0
HFD1_k127_6776267_1 C-C_Bond_Lyase of the TIM-Barrel fold K01644 - 4.1.3.34 0.00000000000000000000000000000004743 126.0
HFD1_k127_6776267_2 Protein of unknown function (DUF3833) - - - 0.000000000000000000006015 100.0
HFD1_k127_6819745_0 His Kinase A (phosphoacceptor) domain - - - 8.654e-263 818.0
HFD1_k127_6891461_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.558e-210 657.0
HFD1_k127_6891461_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 391.0
HFD1_k127_6891461_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 301.0
HFD1_k127_6891461_3 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000001362 188.0
HFD1_k127_6900517_0 receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 564.0
HFD1_k127_6900517_1 ChrR Cupin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009258 341.0
HFD1_k127_6900517_2 Glutathione S-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 324.0
HFD1_k127_6900517_3 Phage shock protein A K03969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003333 264.0
HFD1_k127_6900517_4 - - - - 0.00000000000000000000000000000000000000000000000002953 180.0
HFD1_k127_6900517_5 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000003376 172.0
HFD1_k127_6900517_6 - - - - 0.0000000000000000001679 90.0
HFD1_k127_6900517_7 positive regulation of macromolecule biosynthetic process K03973 - - 0.000000000000000003924 89.0
HFD1_k127_6931966_0 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) K09883 - 6.6.1.2 2.804e-209 663.0
HFD1_k127_6931966_1 COG1253 Hemolysins and related proteins containing CBS domains K03699 - - 8.579e-202 637.0
HFD1_k127_6931966_10 Uncharacterized protein conserved in bacteria (DUF2093) - - - 0.00000000000000000000001385 103.0
HFD1_k127_6931966_2 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006881 597.0
HFD1_k127_6931966_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 580.0
HFD1_k127_6931966_4 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000000000000000000000000000008006 230.0
HFD1_k127_6931966_5 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000008004 231.0
HFD1_k127_6931966_6 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000000000000000000000000000000005045 171.0
HFD1_k127_6931966_7 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000003883 164.0
HFD1_k127_6931966_8 NADH ubiquinone oxidoreductase 41 kD complex I subunit - - - 0.000000000000000000000000000002522 126.0
HFD1_k127_6931966_9 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.000000000000000000000000001326 121.0
HFD1_k127_6950823_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 422.0
HFD1_k127_6950823_1 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 358.0
HFD1_k127_6950823_2 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 353.0
HFD1_k127_6950823_3 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 318.0
HFD1_k127_6950823_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 313.0
HFD1_k127_6950823_5 UDP-N-acetylmuramate-alanine ligase K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 297.0
HFD1_k127_6950823_6 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003356 243.0
HFD1_k127_6950823_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000002727 226.0
HFD1_k127_6950823_8 - - - - 0.0000000000000000000000000000000000000000000000000000000216 201.0
HFD1_k127_6950823_9 - - - - 0.000000000000000000000000000000000000003109 149.0
HFD1_k127_6954284_0 Belongs to the heme-copper respiratory oxidase family K04561 - 1.7.2.5 3.924e-318 993.0
HFD1_k127_6954284_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 320.0
HFD1_k127_6954284_2 - - - - 0.0000000000364 67.0
HFD1_k127_6959119_0 X-Pro dipeptidyl-peptidase domain protein K06978 - - 8.513e-278 869.0
HFD1_k127_6959119_1 Domain of unknown function (DUF4130 K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003253 281.0
HFD1_k127_6959119_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000133 258.0
HFD1_k127_6959119_3 PFAM FMN-binding domain protein - - - 0.0000000000000000000000000000000000003966 144.0
HFD1_k127_6966690_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1311.0
HFD1_k127_6966690_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.99e-251 785.0
HFD1_k127_6966690_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006912 481.0
HFD1_k127_6966690_11 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 461.0
HFD1_k127_6966690_12 Fatty acid desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 449.0
HFD1_k127_6966690_13 molecular chaperone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 436.0
HFD1_k127_6966690_14 ribonuclease BN K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 426.0
HFD1_k127_6966690_15 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 401.0
HFD1_k127_6966690_16 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 368.0
HFD1_k127_6966690_17 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 283.0
HFD1_k127_6966690_18 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000111 261.0
HFD1_k127_6966690_19 Ferric reductase like transmembrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000203 263.0
HFD1_k127_6966690_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.373e-239 745.0
HFD1_k127_6966690_20 Protein of unknown function (DUF541) K09807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003773 250.0
HFD1_k127_6966690_21 Ribosomal protein L17 K02879 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004349 241.0
HFD1_k127_6966690_22 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000000000000000001312 196.0
HFD1_k127_6966690_23 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000000000000000000000000000000001719 198.0
HFD1_k127_6966690_24 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000174 209.0
HFD1_k127_6966690_25 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000000000002829 185.0
HFD1_k127_6966690_26 Protein of unknown function (DUF1153) - - - 0.000000000000000000000000000000000000000000000002692 173.0
HFD1_k127_6966690_27 Belongs to the HesB IscA family - - - 0.000000000000000000000000000000000000000002264 159.0
HFD1_k127_6966690_28 Transglycosylase associated protein - - - 0.000000000000000000000000000000638 124.0
HFD1_k127_6966690_29 Transglycosylase associated protein - - - 0.000000000000000000000000000136 117.0
HFD1_k127_6966690_3 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 3.004e-226 706.0
HFD1_k127_6966690_31 Domain of unknown function (DUF4136) - - - 0.0000000000000000000000002445 114.0
HFD1_k127_6966690_32 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000000000000000000003598 102.0
HFD1_k127_6966690_33 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000003692 97.0
HFD1_k127_6966690_34 Histone acetyltransferase - - - 0.00000000000001063 84.0
HFD1_k127_6966690_37 Flavin-binding monooxygenase-like - GO:0003674,GO:0003824,GO:0004497,GO:0004499,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0012505,GO:0016020,GO:0016491,GO:0016705,GO:0016709,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0055114,GO:0098827 - 0.0009906 45.0
HFD1_k127_6966690_4 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007736 594.0
HFD1_k127_6966690_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007841 563.0
HFD1_k127_6966690_6 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 546.0
HFD1_k127_6966690_7 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 543.0
HFD1_k127_6966690_8 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 535.0
HFD1_k127_6966690_9 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 473.0
HFD1_k127_6970643_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.819e-300 935.0
HFD1_k127_6970643_1 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.113e-218 687.0
HFD1_k127_6970643_10 Tetratricopeptide repeat - - - 0.00000000002922 67.0
HFD1_k127_6970643_11 Stress-induced bacterial acidophilic repeat motif K06884 - - 0.00000002245 57.0
HFD1_k127_6970643_12 Protein of unknown function - - - 0.0009029 50.0
HFD1_k127_6970643_2 Erythromycin esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 582.0
HFD1_k127_6970643_3 PFAM Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 546.0
HFD1_k127_6970643_4 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004189 262.0
HFD1_k127_6970643_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000001818 241.0
HFD1_k127_6970643_6 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000000000000000000000002041 185.0
HFD1_k127_6970643_7 PFAM Sterol-binding domain protein - - - 0.0000000000000000000000000000000000000004341 150.0
HFD1_k127_6970643_8 ACT domain - - - 0.00000000000000000007935 102.0
HFD1_k127_6970643_9 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000001335 85.0
HFD1_k127_6986824_0 YjgP YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 518.0
HFD1_k127_6986824_1 Diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 409.0
HFD1_k127_6986824_2 YjgP YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005369 408.0
HFD1_k127_6986824_3 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 319.0
HFD1_k127_6986824_4 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000000000000005969 166.0
HFD1_k127_705260_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1100.0
HFD1_k127_705260_1 Inner membrane protein CreD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 482.0
HFD1_k127_705260_2 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 439.0
HFD1_k127_705260_3 glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004584 396.0
HFD1_k127_705260_4 Belongs to the Nudix hydrolase family K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 308.0
HFD1_k127_705260_5 cytochrome C K08738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000779 278.0
HFD1_k127_705260_6 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000027 266.0
HFD1_k127_705260_7 Protein of unknown function (DUF721) - - - 0.000000000000000000000000000000000000000000000000000000000000009146 221.0
HFD1_k127_705260_8 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000005325 201.0
HFD1_k127_705260_9 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000006979 190.0
HFD1_k127_7097480_0 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 5.103e-210 659.0
HFD1_k127_7097480_1 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 608.0
HFD1_k127_7097480_2 Transketolase, thiamine diphosphate binding domain K00163 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 560.0
HFD1_k127_7097480_3 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K09699 - 2.3.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 557.0
HFD1_k127_7097480_4 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 502.0
HFD1_k127_7097480_5 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001618 261.0
HFD1_k127_7097480_6 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008465 263.0
HFD1_k127_7097480_7 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000000000000000000006365 198.0
HFD1_k127_7097480_8 - - - - 0.0000000000000000000000000006633 116.0
HFD1_k127_7097480_9 Protein of unknown function (DUF3297) - - - 0.000001872 49.0
HFD1_k127_7145631_0 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008064 512.0
HFD1_k127_7145631_1 protein conserved in bacteria K09973 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 326.0
HFD1_k127_7145631_2 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 296.0
HFD1_k127_7145631_3 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 290.0
HFD1_k127_7145631_4 protein conserved in bacteria K09973 - - 0.0000000000000000000000000000000000000000000000000000000004763 211.0
HFD1_k127_715537_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 327.0
HFD1_k127_715537_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004919 295.0
HFD1_k127_715659_0 thymidine phosphorylase K00758 - 2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 474.0
HFD1_k127_715659_1 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 292.0
HFD1_k127_715659_2 ATPase, P-type transporting, HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000002282 218.0
HFD1_k127_7237377_0 ABC-type multidrug transport system, ATPase and permease K06147 - - 2.319e-257 805.0
HFD1_k127_7237377_1 COG0729 Outer membrane protein K07278 - - 1.808e-201 647.0
HFD1_k127_7237377_10 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 342.0
HFD1_k127_7237377_11 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 336.0
HFD1_k127_7237377_12 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 330.0
HFD1_k127_7237377_13 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 329.0
HFD1_k127_7237377_14 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 304.0
HFD1_k127_7237377_15 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008151 305.0
HFD1_k127_7237377_16 COG3243 Poly(3-hydroxyalkanoate) synthetase K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 291.0
HFD1_k127_7237377_17 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006997 259.0
HFD1_k127_7237377_18 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000531 222.0
HFD1_k127_7237377_19 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000009967 221.0
HFD1_k127_7237377_2 de-polymerase K05973 - 3.1.1.75 3.112e-201 634.0
HFD1_k127_7237377_20 synthesis repressor PhaR - - - 0.000000000000000000000000000000000000000000000000000000000007069 219.0
HFD1_k127_7237377_21 - - - - 0.0000000000000000000000000000000000000000000000008912 188.0
HFD1_k127_7237377_22 - - - - 0.000000000000000000000005854 107.0
HFD1_k127_7237377_24 protein conserved in bacteria K09800 - - 0.00000000000000000000005777 108.0
HFD1_k127_7237377_25 - - - - 0.000000000000000000007387 94.0
HFD1_k127_7237377_26 - - - - 0.0000000000000003546 79.0
HFD1_k127_7237377_27 - - - - 0.0000000000000008426 88.0
HFD1_k127_7237377_29 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000002617 53.0
HFD1_k127_7237377_3 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 8.261e-199 626.0
HFD1_k127_7237377_4 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 547.0
HFD1_k127_7237377_5 decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 516.0
HFD1_k127_7237377_6 Bacterial extracellular solute-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 464.0
HFD1_k127_7237377_7 DNA topoisomerase K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005396 402.0
HFD1_k127_7237377_8 Part of the ABC transporter complex cysAWTP involved in sulfate thiosulfate import K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 387.0
HFD1_k127_7237377_9 sulfate transport system, permease K02046,K15496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005372 357.0
HFD1_k127_7267892_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 7.864e-256 795.0
HFD1_k127_7267892_1 peptidylprolyl isomerase K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007752 571.0
HFD1_k127_7267892_2 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 562.0
HFD1_k127_7267892_3 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 503.0
HFD1_k127_7267892_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 490.0
HFD1_k127_7267892_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 389.0
HFD1_k127_7267892_6 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000007298 252.0
HFD1_k127_7267892_7 Type IV pilus biogenesis stability protein PilW - - - 0.0000000000000000000000000000000000226 141.0
HFD1_k127_7279823_0 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007438 359.0
HFD1_k127_7279823_1 Protein phosphatase 2A homologues, catalytic domain. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 342.0
HFD1_k127_7279823_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006742 254.0
HFD1_k127_7279823_3 Domain of unknown function (DUF4956) - - - 0.00000000000000000000000000000000000000000000000000000000005544 211.0
HFD1_k127_7279823_4 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000001398 197.0
HFD1_k127_7279823_5 Belongs to the BI1 family K06890 - - 0.0000000000000000000000000000000000000000006015 162.0
HFD1_k127_7279823_6 NUDIX domain - - - 0.0000000000000000000000000001421 121.0
HFD1_k127_7279823_7 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000005896 98.0
HFD1_k127_7327013_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.705e-303 935.0
HFD1_k127_7327013_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005612 526.0
HFD1_k127_7327013_2 peptidylprolyl isomerase K01802,K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 482.0
HFD1_k127_7327013_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 289.0
HFD1_k127_7327013_4 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000127 283.0
HFD1_k127_7327013_5 Belongs to the Orn Lys Arg decarboxylase class-II family K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000001299 265.0
HFD1_k127_7327013_6 Preprotein translocase subunit SecG K03075 - - 0.000000000000000000000000004543 114.0
HFD1_k127_7327013_7 - - - - 0.00000001557 57.0
HFD1_k127_7337786_0 cytochrome C K02198 - - 1.217e-252 792.0
HFD1_k127_7337786_1 Alkyl hydroperoxide reductase K02199 - - 0.000000000000000000000000000000000000000000001242 173.0
HFD1_k127_7348843_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 5.654e-238 752.0
HFD1_k127_7348843_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009271 428.0
HFD1_k127_7348843_2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006278 419.0
HFD1_k127_7348843_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008744 375.0
HFD1_k127_7348843_4 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000001031 159.0
HFD1_k127_7348843_5 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000003955 124.0
HFD1_k127_7348843_6 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000000000004069 116.0
HFD1_k127_7352990_0 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 403.0
HFD1_k127_7352990_1 Belongs to the UPF0301 (AlgH) family K07735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 336.0
HFD1_k127_7352990_2 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 317.0
HFD1_k127_7352990_3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 293.0
HFD1_k127_7352990_4 Alkyl hydroperoxide reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000148 266.0
HFD1_k127_7352990_5 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000004243 203.0
HFD1_k127_7352990_6 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000001182 194.0
HFD1_k127_7366736_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1207.0
HFD1_k127_7366736_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1158.0
HFD1_k127_7366736_10 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000000000000000000000003453 210.0
HFD1_k127_7366736_11 Domain of unknown function (DUF4893) - - - 0.00000000000000000000000000000000000000000000000000000397 197.0
HFD1_k127_7366736_12 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.0000000000000000000000000000000000000000000000004926 191.0
HFD1_k127_7366736_13 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000000000001084 154.0
HFD1_k127_7366736_14 amidohydrolase - - - 0.000000000000000000000000000000000000006646 147.0
HFD1_k127_7366736_15 COG1073 Hydrolases of the alpha beta superfamily K06889,K07397 - - 0.00000000000000000000000000000000004953 140.0
HFD1_k127_7366736_2 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006973 522.0
HFD1_k127_7366736_3 alcohol dehydrogenase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007984 454.0
HFD1_k127_7366736_4 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 388.0
HFD1_k127_7366736_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 380.0
HFD1_k127_7366736_6 metalloprotease K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 337.0
HFD1_k127_7366736_7 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 313.0
HFD1_k127_7366736_8 Nucleic-acid-binding protein K07742 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004644 274.0
HFD1_k127_7366736_9 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001666 269.0
HFD1_k127_7374665_0 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 1.664e-262 811.0
HFD1_k127_7374665_1 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009114 591.0
HFD1_k127_7374665_2 protein conserved in bacteria K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002975 279.0
HFD1_k127_7381043_0 coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 443.0
HFD1_k127_7381043_1 Nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005496 338.0
HFD1_k127_7381043_2 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008625 308.0
HFD1_k127_7381043_3 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003552 270.0
HFD1_k127_7381043_4 N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000007543 242.0
HFD1_k127_7381043_5 thioesterase K07107 - - 0.000000000000000000000000000000000000000000000000000000001387 201.0
HFD1_k127_7381043_6 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000000003228 197.0
HFD1_k127_7381043_7 - - - - 0.0000000000000000000000000008381 113.0
HFD1_k127_7381043_8 - - - - 0.0000000000002775 80.0
HFD1_k127_7381916_0 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009738 402.0
HFD1_k127_7381916_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 367.0
HFD1_k127_7381916_2 Dehydrogenase K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 359.0
HFD1_k127_7381916_4 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.00000000002128 65.0
HFD1_k127_7393762_0 DNA ligase K01971 - 6.5.1.1 0.0 1189.0
HFD1_k127_7393762_1 COG2366 Protein related to penicillin acylase - - - 8.9e-322 1001.0
HFD1_k127_7393762_10 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 405.0
HFD1_k127_7393762_11 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006589 399.0
HFD1_k127_7393762_12 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 394.0
HFD1_k127_7393762_13 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 394.0
HFD1_k127_7393762_14 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 392.0
HFD1_k127_7393762_15 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine K03648 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 385.0
HFD1_k127_7393762_16 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006633 393.0
HFD1_k127_7393762_17 Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007648 353.0
HFD1_k127_7393762_18 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 311.0
HFD1_k127_7393762_19 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 293.0
HFD1_k127_7393762_2 Transporter - - - 2.662e-276 864.0
HFD1_k127_7393762_20 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 282.0
HFD1_k127_7393762_21 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002036 285.0
HFD1_k127_7393762_22 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003764 282.0
HFD1_k127_7393762_23 Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000382 274.0
HFD1_k127_7393762_24 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006629 280.0
HFD1_k127_7393762_25 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000001401 247.0
HFD1_k127_7393762_26 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000000000000000000000000000004456 235.0
HFD1_k127_7393762_27 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000000000000000009822 197.0
HFD1_k127_7393762_28 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000002526 187.0
HFD1_k127_7393762_3 glutamate--cysteine ligase K01919 - 6.3.2.2 1.375e-224 703.0
HFD1_k127_7393762_30 Protein of unknown function (DUF3035) - - - 0.00000000000000000000000000000005347 129.0
HFD1_k127_7393762_32 response regulator K02282,K07782,K19135 - - 0.000000000000000000000004371 109.0
HFD1_k127_7393762_33 - - - - 0.0000000000000000001662 98.0
HFD1_k127_7393762_34 - - - - 0.0000000000001222 81.0
HFD1_k127_7393762_37 SnoaL-like domain - - - 0.0009782 49.0
HFD1_k127_7393762_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 586.0
HFD1_k127_7393762_5 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 582.0
HFD1_k127_7393762_6 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008067 500.0
HFD1_k127_7393762_7 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 451.0
HFD1_k127_7393762_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 449.0
HFD1_k127_7393762_9 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 421.0
HFD1_k127_7454377_0 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 399.0
HFD1_k127_7454377_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 345.0
HFD1_k127_7454377_2 Cell division protein FtsI penicillin-binding protein K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 331.0
HFD1_k127_7454377_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005241 268.0
HFD1_k127_7454377_4 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005776 247.0
HFD1_k127_7454377_5 - - - - 0.000000000000000000000000000000000000000006538 166.0
HFD1_k127_7454377_6 - - - - 0.000000000000000000000000000000002875 138.0
HFD1_k127_7454377_7 - - - - 0.00000000000000000001072 96.0
HFD1_k127_7474876_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1197.0
HFD1_k127_7474876_1 DEAD DEAH box helicase K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006961 507.0
HFD1_k127_7474876_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 474.0
HFD1_k127_7474876_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 432.0
HFD1_k127_7474876_4 Carbohydrate-selective porin, OprB family K07267 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003127 324.0
HFD1_k127_7474876_5 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000004691 158.0
HFD1_k127_7474876_6 Cytochrome c - - - 0.00000000000000000000000000006084 121.0
HFD1_k127_7521102_0 Protein of unknown function (DUF3089) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006794 416.0
HFD1_k127_7521102_1 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000000000000000000000000000002606 205.0
HFD1_k127_7521102_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000002757 148.0
HFD1_k127_7555949_0 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 593.0
HFD1_k127_7555949_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 574.0
HFD1_k127_7555949_2 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 309.0
HFD1_k127_7555949_3 Outer membrane receptor proteins, mostly Fe transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001762 247.0
HFD1_k127_7555949_4 Acyl-CoA hydrolase K10806 - - 0.00000000000000000000000000000000000000000000000000000206 194.0
HFD1_k127_7555949_5 Domain of unknown function (DUF4167) - - - 0.00000000000000000000000000000000000003746 150.0
HFD1_k127_7555949_6 - - - - 0.000003116 54.0
HFD1_k127_7573982_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1020.0
HFD1_k127_7573982_1 Belongs to the Fur family K09823 - - 0.000000000000000000000000000000000000000000000000000000000000000000007659 236.0
HFD1_k127_7573982_2 MerC mercury resistance protein - - - 0.000000000000000000006924 93.0
HFD1_k127_7574606_0 Voltage-dependent anion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005261 567.0
HFD1_k127_7574606_1 Cupin domain - - - 0.00000000000000000000000000000000000000002246 154.0
HFD1_k127_7574606_2 Aldo/keto reductase family - - - 0.0000000000000000000000008919 104.0
HFD1_k127_7574606_3 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000006973 72.0
HFD1_k127_7574606_4 Protein of unknown function (DUF2845) - - - 0.0000000000003319 74.0
HFD1_k127_7599636_0 TonB dependent receptor - - - 0.0 1089.0
HFD1_k127_7599636_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 7.617e-200 627.0
HFD1_k127_7599636_10 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000408 245.0
HFD1_k127_7599636_11 Peptidase family M48 - - - 0.000000000002844 67.0
HFD1_k127_7599636_12 - - - - 0.00000002146 64.0
HFD1_k127_7599636_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.366e-194 622.0
HFD1_k127_7599636_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 537.0
HFD1_k127_7599636_4 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 478.0
HFD1_k127_7599636_5 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 478.0
HFD1_k127_7599636_6 Major facilitator superfamily K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 475.0
HFD1_k127_7599636_7 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 391.0
HFD1_k127_7599636_8 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 369.0
HFD1_k127_7599636_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006781 254.0
HFD1_k127_7619876_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1258.0
HFD1_k127_7619876_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 7.863e-252 788.0
HFD1_k127_7619876_10 - - - - 0.000000001302 63.0
HFD1_k127_7619876_2 Heparinase - - - 5.256e-228 718.0
HFD1_k127_7619876_3 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 572.0
HFD1_k127_7619876_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 466.0
HFD1_k127_7619876_5 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 448.0
HFD1_k127_7619876_6 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 353.0
HFD1_k127_7619876_7 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 334.0
HFD1_k127_7619876_8 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 287.0
HFD1_k127_7642343_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 3.538e-243 757.0
HFD1_k127_7642343_1 beta-glucosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009883 506.0
HFD1_k127_7642343_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 450.0
HFD1_k127_7642343_3 Belongs to the glycosyl hydrolase 43 family K06113 - 3.2.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000972 409.0
HFD1_k127_7642343_4 Dehydroquinase class II K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000002367 175.0
HFD1_k127_7642343_5 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000001256 164.0
HFD1_k127_7642343_6 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000005827 146.0
HFD1_k127_7642343_7 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000000000000001817 106.0
HFD1_k127_7642343_8 ubiE/COQ5 methyltransferase family - - - 0.00004872 46.0
HFD1_k127_7864585_0 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000638 565.0
HFD1_k127_7864585_1 protein conserved in bacteria K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 475.0
HFD1_k127_7864585_10 Peptidyl-prolyl cis-trans K03772 - 5.2.1.8 0.0000000000000000001997 94.0
HFD1_k127_7864585_12 - - - - 0.00000000001125 73.0
HFD1_k127_7864585_13 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.000222 48.0
HFD1_k127_7864585_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 401.0
HFD1_k127_7864585_3 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 367.0
HFD1_k127_7864585_4 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001346 266.0
HFD1_k127_7864585_5 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000000000000000000000000000000000001308 221.0
HFD1_k127_7864585_6 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000005439 134.0
HFD1_k127_7864585_7 - - - - 0.0000000000000000000000000000000002184 133.0
HFD1_k127_7864585_8 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000001374 115.0
HFD1_k127_7900026_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 9.43e-220 697.0
HFD1_k127_7900026_1 Cytochrome c1 K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 399.0
HFD1_k127_7900026_2 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 289.0
HFD1_k127_7900026_3 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000114 164.0
HFD1_k127_7900026_4 dehydratase - - - 0.00000000000000000000000004776 109.0
HFD1_k127_7900026_5 - - - - 0.0000000000000000000004739 102.0
HFD1_k127_7947019_0 gag-polyprotein putative aspartyl protease K06985 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007081 254.0
HFD1_k127_7947019_1 Pfam:Pyridox_oxidase - - - 0.000000000000000000000000000000001102 136.0
HFD1_k127_7947019_2 - - - - 0.00000002203 57.0
HFD1_k127_819738_0 overlaps another CDS with the same product name K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 466.0
HFD1_k127_819738_1 Alpha Beta K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 422.0
HFD1_k127_819738_2 overlaps another CDS with the same product name K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 424.0
HFD1_k127_819738_3 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 406.0
HFD1_k127_819738_4 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 297.0
HFD1_k127_819738_5 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000003757 213.0
HFD1_k127_819738_6 Ferredoxin K04755 - - 0.00000000000000000000000007172 112.0
HFD1_k127_837956_0 5-aminolevulinic acid synthase K00643 - 2.3.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 535.0
HFD1_k127_837956_1 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 475.0
HFD1_k127_837956_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 353.0
HFD1_k127_837956_3 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000004083 224.0
HFD1_k127_837956_4 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000004918 230.0
HFD1_k127_842511_0 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 2.453e-282 880.0
HFD1_k127_842511_1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009655 437.0
HFD1_k127_842511_2 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 385.0
HFD1_k127_842511_3 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 328.0
HFD1_k127_842511_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.00000000000000000000000000000000000000000000000000000001045 202.0
HFD1_k127_842511_5 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000313 196.0
HFD1_k127_892854_0 aminopeptidase K01262 - 3.4.11.9 1.315e-299 927.0
HFD1_k127_892854_1 Threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009411 478.0
HFD1_k127_892854_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000004124 214.0
HFD1_k127_892854_3 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000006307 186.0
HFD1_k127_892854_4 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000003699 159.0
HFD1_k127_892854_5 Protein of unknown function (DUF1059) - - - 0.000000000000000000001251 96.0
HFD1_k127_939316_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 3.453e-296 922.0
HFD1_k127_939316_1 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 510.0
HFD1_k127_939316_10 - - - - 0.000000000000000000000000000000000000000000000000000000004293 202.0
HFD1_k127_939316_11 Regulatory protein RecX K03565 - - 0.00000000000000000000000000000000000000000008659 168.0
HFD1_k127_939316_12 NADH ubiquinone oxidoreductase 17.2 kD subunit - - - 0.0000000000000000000000000000000000000000001013 163.0
HFD1_k127_939316_13 Bacterial protein of unknown function (Gcw_chp) - - - 0.0000000000000000000000000000000000000000001162 168.0
HFD1_k127_939316_14 Putative zinc-finger - - - 0.000000000000000000000000000000000000006371 154.0
HFD1_k127_939316_15 ArsC family K00537 - 1.20.4.1 0.000000000000000000000000000000000004888 143.0
HFD1_k127_939316_16 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000002694 137.0
HFD1_k127_939316_17 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000001056 130.0
HFD1_k127_939316_18 Prokaryotic cytochrome b561 K12262 - - 0.0000000000000000000000000001361 123.0
HFD1_k127_939316_19 Cytochrome c K08738 - - 0.000000000000000000000006598 106.0
HFD1_k127_939316_2 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009226 432.0
HFD1_k127_939316_20 - - - - 0.000000000000000000003564 94.0
HFD1_k127_939316_21 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00000000000000000003317 92.0
HFD1_k127_939316_24 PilZ domain - - - 0.000186 48.0
HFD1_k127_939316_3 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 432.0
HFD1_k127_939316_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 379.0
HFD1_k127_939316_5 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 306.0
HFD1_k127_939316_6 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 292.0
HFD1_k127_939316_8 Sigma-70, region 4 - - - 0.000000000000000000000000000000000000000000000000000000000000539 216.0
HFD1_k127_939316_9 Cold shock protein domain K03704 - - 0.0000000000000000000000000000000000000000000000000000000000005866 216.0
HFD1_k127_992388_0 E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate K00164 - 1.2.4.2 4.904e-263 816.0
HFD1_k127_992388_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000373 235.0