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Overview

ID MAG01753
Name HKD1_bin.73
Sample SMP0046
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanosarcinia
Order Methanotrichales
Family Methanotrichaceae
Genus JALHSR01
Species
Assembly information
Completeness (%) 79.17
Contamination (%) 3.14
GC content (%) 42.0
N50 (bp) 7,173
Genome size (bp) 2,198,298

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1935

Gene name Description KEGG GOs EC E-value Score Sequence
HKD1_k127_1005977_0 Dipeptidase K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 433.0
HKD1_k127_1005977_1 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001577 254.0
HKD1_k127_1005977_2 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000003473 117.0
HKD1_k127_1005977_3 membrane protein domain - - - 0.0000000000000000001863 92.0
HKD1_k127_1005977_4 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.00000000000000005165 84.0
HKD1_k127_1005977_5 Phospholipid methyltransferase - - - 0.00000000000003602 79.0
HKD1_k127_103303_0 CoA binding domain - - - 9.464e-255 803.0
HKD1_k127_103303_1 ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues K01648 GO:0000166,GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003878,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006084,GO:0006085,GO:0006101,GO:0006107,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009893,GO:0009987,GO:0012505,GO:0015936,GO:0016020,GO:0016053,GO:0016125,GO:0016126,GO:0016192,GO:0016740,GO:0016746,GO:0016999,GO:0017076,GO:0017144,GO:0018130,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030141,GO:0030554,GO:0031323,GO:0031325,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032940,GO:0032991,GO:0033500,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0034774,GO:0035337,GO:0035383,GO:0035384,GO:0035578,GO:0035639,GO:0036094,GO:0036230,GO:0042119,GO:0042582,GO:0042592,GO:0042593,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046165,GO:0046390,GO:0046394,GO:0046483,GO:0046903,GO:0046912,GO:0046949,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0055086,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653,GO:1904813 2.3.3.8 2.939e-230 729.0
HKD1_k127_103303_11 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000001593 207.0
HKD1_k127_103303_12 integral membrane protein K07027 - - 0.00000000000000000000000000000000000000000000000009099 191.0
HKD1_k127_103303_13 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000001152 181.0
HKD1_k127_103303_14 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000005594 174.0
HKD1_k127_103303_15 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.0000000000000000000000000000001859 123.0
HKD1_k127_103303_16 Protein of unknown function (DUF473) K09135 - - 0.0000000000000000000000001995 111.0
HKD1_k127_103303_17 PBS lyase HEAT-like repeat - - - 0.0000000000000000000001715 109.0
HKD1_k127_103303_18 Binds to the 23S rRNA K02896 - - 0.0000000000000000009532 86.0
HKD1_k127_103303_19 membrane - - - 0.000000000000000002031 94.0
HKD1_k127_103303_2 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 8.491e-228 720.0
HKD1_k127_103303_20 Belongs to the 'phage' integrase family K04763 - - 0.00000000000001263 83.0
HKD1_k127_103303_21 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000004115 67.0
HKD1_k127_103303_22 Family of unknown function (DUF5350) - - - 0.000000000005849 67.0
HKD1_k127_103303_23 - - - - 0.0000000258 64.0
HKD1_k127_103303_24 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000004719 53.0
HKD1_k127_103303_25 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000005619 53.0
HKD1_k127_103303_26 - - - - 0.0007058 43.0
HKD1_k127_103303_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007043 530.0
HKD1_k127_103303_4 ATP citrate lyase citrate-binding K15231 - 2.3.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 486.0
HKD1_k127_103303_5 PFAM dihydropteroate synthase, DHPS - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 417.0
HKD1_k127_103303_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001958 259.0
HKD1_k127_103303_7 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005376 246.0
HKD1_k127_103303_8 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000008314 242.0
HKD1_k127_103303_9 DNA polymerase Ligase (LigD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000006438 235.0
HKD1_k127_1039329_0 mechanosensitive ion channel activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 594.0
HKD1_k127_1039329_1 SPFH domain / Band 7 family - - - 0.000000000000000007895 90.0
HKD1_k127_1039329_2 SEC-C motif K01265 - 3.4.11.18 0.00000001284 57.0
HKD1_k127_1054642_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 1.427e-276 867.0
HKD1_k127_1054642_1 PFAM glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 332.0
HKD1_k127_1060381_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000006087 102.0
HKD1_k127_1060381_1 Acetyltransferase (GNAT) domain - - - 0.000000001141 70.0
HKD1_k127_1099621_0 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 454.0
HKD1_k127_1099621_1 alkylhydroperoxidase like protein, AhpD family - - - 0.000000000000000000005293 97.0
HKD1_k127_1099621_2 silverDB - - - 0.00000000000000004328 85.0
HKD1_k127_1099621_3 PFAM CBS domain K04767 - - 0.00001369 49.0
HKD1_k127_1099621_4 Protein of unknown function (DUF1059) - - - 0.0005679 45.0
HKD1_k127_1107828_0 PFAM Thiolase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 524.0
HKD1_k127_1107828_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000004171 179.0
HKD1_k127_1107828_2 Lrp/AsnC ligand binding domain - - - 0.0000000007439 66.0
HKD1_k127_1107828_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000004304 62.0
HKD1_k127_1107828_4 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00581 - 2.1.1.86 0.000000006051 59.0
HKD1_k127_1113919_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 584.0
HKD1_k127_1113919_1 Histone deacetylase domain K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 310.0
HKD1_k127_1113919_2 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008045 251.0
HKD1_k127_1113919_3 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.0000000000000000000000000000000009364 132.0
HKD1_k127_1113919_4 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - 0.00000000000000000000000000001143 120.0
HKD1_k127_1113919_5 PFAM Adenylate cyclase K05873 GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849 4.6.1.1 0.00000000000000000000000009353 111.0
HKD1_k127_1130981_0 AAA family ATPase, CDC48 subfamily K13525 - - 4.635e-296 925.0
HKD1_k127_1130981_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 558.0
HKD1_k127_1130981_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 371.0
HKD1_k127_1130981_3 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000002481 202.0
HKD1_k127_1130981_4 PFAM regulatory protein, ArsR K07721 - - 0.00000000000000000000000000000004059 133.0
HKD1_k127_1130981_5 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000017 118.0
HKD1_k127_1130981_6 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - - 0.000000000000000703 83.0
HKD1_k127_1150396_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1356.0
HKD1_k127_1150396_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 434.0
HKD1_k127_1150396_2 PFAM cyclase family protein K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000002451 178.0
HKD1_k127_1150396_3 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000005099 130.0
HKD1_k127_1150396_4 protein N-acetylglucosaminyltransferase activity K12600 - - 0.00000000000000000000002047 103.0
HKD1_k127_1150396_5 PFAM Protein kinase domain - - - 0.0000000001151 65.0
HKD1_k127_1150396_6 TPR repeat-containing protein - - - 0.0000008305 54.0
HKD1_k127_1153521_0 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000000005584 185.0
HKD1_k127_1153521_1 Uncharacterised BCR, YnfA/UPF0060 family K09771 - - 0.000000000006031 66.0
HKD1_k127_1153521_2 PFAM Uncharacterised BCR, YnfA UPF0060 family K09771 - - 0.000000000009931 68.0
HKD1_k127_1153521_3 Copper binding proteins, plastocyanin/azurin family - - - 0.00000002045 55.0
HKD1_k127_1153521_4 DDE superfamily endonuclease - - - 0.0000000342 56.0
HKD1_k127_1153521_5 Glucose / Sorbosone dehydrogenase - - - 0.0006215 44.0
HKD1_k127_1161053_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 387.0
HKD1_k127_1161053_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000004668 178.0
HKD1_k127_1161053_2 - - - - 0.00000000000000000000000000000000001959 137.0
HKD1_k127_1161053_3 integrase family K04763 - - 0.000000000000000000000000000000002695 136.0
HKD1_k127_1161053_4 - - - - 0.000000000000006966 80.0
HKD1_k127_1161053_5 integrase family K04763 - - 0.0000000007448 61.0
HKD1_k127_1162569_0 transposase K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000005244 232.0
HKD1_k127_1162569_1 bacterial OsmY and nodulation domain - - - 0.000000000000000000000000000000000000000000000000000000000000001835 224.0
HKD1_k127_1162569_2 Uncharacterized conserved protein (DUF2173) - - - 0.000000000000000000000000000000000000000000000000000005288 191.0
HKD1_k127_1162569_3 homolog of gamma-carboxymuconolactone decarboxylase subunit - - - 0.0000000000000000000000000000000000000009193 151.0
HKD1_k127_1162569_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000006078 145.0
HKD1_k127_1162569_5 membrane - - - 0.000000000000000000000000000000000001048 143.0
HKD1_k127_1162569_6 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.000000000000000000000000004529 115.0
HKD1_k127_1162569_7 response to heat - - - 0.0000000000000000000000003901 107.0
HKD1_k127_1162569_8 - - - - 0.0000000000000000000000005865 107.0
HKD1_k127_1162569_9 Ferredoxin K05337 - - 0.0000000000000000000006961 96.0
HKD1_k127_1179309_0 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 397.0
HKD1_k127_1187597_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 325.0
HKD1_k127_1187597_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 320.0
HKD1_k127_1187597_2 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000003118 242.0
HKD1_k127_1187597_3 Belongs to the UPF0215 family K09120 - - 0.000539 43.0
HKD1_k127_1190238_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 490.0
HKD1_k127_1190238_1 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 377.0
HKD1_k127_1190238_2 PFAM Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005558 274.0
HKD1_k127_1190238_3 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000000000000000000000000000002709 215.0
HKD1_k127_1190238_4 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000011 166.0
HKD1_k127_1195492_0 PFAM Cache, type 2 domain protein K02030 - - 0.0000000000000000000000000000000002115 136.0
HKD1_k127_1195492_1 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000004626 133.0
HKD1_k127_1195492_2 PFAM Cache, type 2 domain protein K02030 - - 0.00000000000000000000000000007125 121.0
HKD1_k127_1195492_3 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000008798 109.0
HKD1_k127_1195492_4 - - - - 0.000000000000001351 82.0
HKD1_k127_1212223_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 411.0
HKD1_k127_1214890_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 590.0
HKD1_k127_1214890_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 492.0
HKD1_k127_1214890_2 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001332 281.0
HKD1_k127_1214890_3 TIGRFAM archaeoflavoprotein AfpA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009054 246.0
HKD1_k127_1214890_4 integrase family K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000001369 246.0
HKD1_k127_1214890_5 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000002016 241.0
HKD1_k127_1214890_6 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000003491 217.0
HKD1_k127_1214890_7 PFAM Nucleoside 2-deoxyribosyltransferase - - - 0.0000000000000000000000005858 108.0
HKD1_k127_1214890_8 transposase activity - - - 0.000000000000000000000003713 119.0
HKD1_k127_1214890_9 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000002905 77.0
HKD1_k127_1230340_0 PFAM glycosyl transferase family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 4.345e-274 861.0
HKD1_k127_1230340_1 PFAM glycosyl transferase group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008557 534.0
HKD1_k127_1230340_2 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007325 509.0
HKD1_k127_1230340_3 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 352.0
HKD1_k127_1230340_4 PFAM Pyruvate kinase, alpha beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 281.0
HKD1_k127_1230340_5 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008942 244.0
HKD1_k127_1230340_6 PFAM PEBP family protein K06910 - - 0.000000000000000000000000000000000000000000002238 172.0
HKD1_k127_1230340_7 PFAM Secreted repeat of - - - 0.000000000000000000000000001641 117.0
HKD1_k127_1230340_8 PFAM CBS domain containing protein - - - 0.0000000000000000004082 93.0
HKD1_k127_1258806_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006703 306.0
HKD1_k127_1258806_1 Glutathione S-transferase - - - 0.000000000004342 71.0
HKD1_k127_1258806_2 Lamin Tail Domain - - - 0.0000000002147 65.0
HKD1_k127_1258806_3 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 0.0004317 43.0
HKD1_k127_1266776_0 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 345.0
HKD1_k127_1266776_1 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000001178 242.0
HKD1_k127_1266776_10 RibD C-terminal domain K14654 - 1.1.1.302 0.0001071 44.0
HKD1_k127_1266776_2 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000061 207.0
HKD1_k127_1266776_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000001078 188.0
HKD1_k127_1266776_4 Permease - - - 0.00000000000000000000000000000000000000000495 169.0
HKD1_k127_1266776_5 OsmC-like protein K07397 - - 0.00000000000000000003489 94.0
HKD1_k127_1266776_6 amino acid - - - 0.000000000000008896 83.0
HKD1_k127_1266776_7 RibD C-terminal domain K14654 - 1.1.1.302 0.00000000000006352 76.0
HKD1_k127_1266776_8 Protein of unknown function (DUF4064) - - - 0.0000000004152 66.0
HKD1_k127_1266776_9 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.000002465 49.0
HKD1_k127_1285718_0 peptidase K08303 - - 5.568e-223 717.0
HKD1_k127_1285718_1 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006031 391.0
HKD1_k127_1285718_10 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934,K21479 - 2.1.1.131,2.1.1.272 0.0000000000000000000000000000000000000002472 166.0
HKD1_k127_1285718_11 - - - - 0.00000000000000000000000000000000001254 142.0
HKD1_k127_1285718_12 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000000000000000000000000001072 124.0
HKD1_k127_1285718_13 Belongs to the UPF0147 family K09721 - - 0.0000000000000000000000000004604 115.0
HKD1_k127_1285718_14 protein N-acetylglucosaminyltransferase activity K12600 - - 0.00000000000000000000001327 106.0
HKD1_k127_1285718_15 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.00000000007775 68.0
HKD1_k127_1285718_2 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 299.0
HKD1_k127_1285718_3 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 289.0
HKD1_k127_1285718_4 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 288.0
HKD1_k127_1285718_5 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.0000000000000000000000000000000000000000000000000000000000000000007831 235.0
HKD1_k127_1285718_6 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000002853 224.0
HKD1_k127_1285718_7 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000001394 209.0
HKD1_k127_1285718_8 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.00000000000000000000000000000000000000000000000000157 194.0
HKD1_k127_1285718_9 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.000000000000000000000000000000000000000002611 162.0
HKD1_k127_129462_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.88e-273 859.0
HKD1_k127_129462_1 Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide K00399 - 2.8.4.1 6.974e-256 799.0
HKD1_k127_129462_2 PFAM Methyl-coenzyme M reductase, beta subunit K00401 - 2.8.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 578.0
HKD1_k127_129462_3 PFAM Methyl-coenzyme M reductase gamma subunit K00402 - 2.8.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 334.0
HKD1_k127_129462_4 Uncharacterized conserved protein (DUF2173) - - - 0.000000000000000000000000000000000000000000000000000002212 192.0
HKD1_k127_129462_5 Methyl-coenzyme M reductase operon protein D K03422 - - 0.00000000000000000000000000000000000002767 149.0
HKD1_k127_1302173_0 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002611 243.0
HKD1_k127_1302173_1 transcription initiation from RNA polymerase II promoter - - - 0.0001199 44.0
HKD1_k127_1304265_0 protein N-acetylglucosaminyltransferase activity K12600 - - 0.00000000000000000000000000000000001279 146.0
HKD1_k127_1327907_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 393.0
HKD1_k127_1342688_0 PBP superfamily domain K02040 - - 0.000000000000000000000000000000002062 136.0
HKD1_k127_1342688_1 oxidoreductase activity K07114 - - 0.00000005849 64.0
HKD1_k127_1363695_0 Cation transport regulator K06197 - - 0.00000000000000000000000000008275 116.0
HKD1_k127_1363695_2 PFAM blue (type 1) copper domain protein - - - 0.000000000000000003009 96.0
HKD1_k127_1425788_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 584.0
HKD1_k127_1425788_1 Mn2 dependent serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000492 418.0
HKD1_k127_1425788_10 Non-histone chromosomal protein MC1 - - - 0.0000000000000000000000000002912 115.0
HKD1_k127_1425788_11 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.00000000000000000000000001897 111.0
HKD1_k127_1425788_12 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000002757 72.0
HKD1_k127_1425788_13 SPTR Transposase, IS4 family protein - - - 0.000000001235 61.0
HKD1_k127_1425788_2 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 299.0
HKD1_k127_1425788_3 RNA methylase K07446 - 2.1.1.213 0.00000000000000000000000000000000000000000000000000000000000000000000000000001753 270.0
HKD1_k127_1425788_4 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009579 242.0
HKD1_k127_1425788_5 Transcription elongation factor Spt5 K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000124 226.0
HKD1_k127_1425788_6 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000003636 226.0
HKD1_k127_1425788_7 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000000003158 179.0
HKD1_k127_1425788_8 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000001165 175.0
HKD1_k127_1425788_9 - - - - 0.0000000000000000000000000000000000000001604 156.0
HKD1_k127_1427698_0 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.00000000000000000000000000004063 119.0
HKD1_k127_1427698_1 cytochrome c biogenesis protein, transmembrane region K06196 - - 0.00000000001409 77.0
HKD1_k127_144207_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 4.692e-202 636.0
HKD1_k127_144207_1 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.0000000000000000000000000000000000000000000000000004315 189.0
HKD1_k127_144207_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000001337 59.0
HKD1_k127_1458018_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 495.0
HKD1_k127_1458018_1 Uncharacterized protein family (UPF0051) K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 417.0
HKD1_k127_1458018_2 PFAM ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 291.0
HKD1_k127_1458018_3 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006766 285.0
HKD1_k127_1458018_4 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000001713 265.0
HKD1_k127_1458018_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008251 259.0
HKD1_k127_1458018_6 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000007125 218.0
HKD1_k127_1458018_7 Kelch motif - - - 0.000000000000000000000004178 109.0
HKD1_k127_1458018_8 - - - - 0.0000000001835 64.0
HKD1_k127_1463301_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 527.0
HKD1_k127_1463301_1 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 463.0
HKD1_k127_1463301_10 Isoprenylcysteine carboxyl methyltransferase - - - 0.00000004277 57.0
HKD1_k127_1463301_12 Fibronectin type III domain - - - 0.00006094 49.0
HKD1_k127_1463301_13 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0003761 47.0
HKD1_k127_1463301_2 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000001089 243.0
HKD1_k127_1463301_3 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000002697 256.0
HKD1_k127_1463301_4 Transposase domain (DUF772) K07481 - - 0.0000000000000000000000000000000000000000005626 160.0
HKD1_k127_1463301_5 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.000000000000000000000000000002769 124.0
HKD1_k127_1463301_6 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000003354 115.0
HKD1_k127_1463301_7 DNA photolyase activity - - - 0.000000000000000001087 93.0
HKD1_k127_1463301_8 Protein of unknown function, DUF488 - - - 0.0000000002181 63.0
HKD1_k127_1463301_9 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.0000000003595 63.0
HKD1_k127_146663_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 2.503e-225 708.0
HKD1_k127_146663_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001925 249.0
HKD1_k127_1483669_0 Flavoprotein K18853 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0042558,GO:0042559,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901283,GO:1901285,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:2001115,GO:2001116,GO:2001117,GO:2001118 1.5.99.15 0.00000000000000000000000000000000000000000000000000000000000000002343 230.0
HKD1_k127_1483669_1 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000002232 143.0
HKD1_k127_1483669_2 PFAM molybdopterin biosynthesis MoaE K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.000000000000000000000000000000005292 134.0
HKD1_k127_1483669_3 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000001102 102.0
HKD1_k127_1483669_5 DDE superfamily endonuclease - - - 0.000000000001866 68.0
HKD1_k127_1483669_6 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K04763 - - 0.00000000001362 74.0
HKD1_k127_1483669_7 - - - - 0.00004876 49.0
HKD1_k127_15361_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005161 553.0
HKD1_k127_15361_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 325.0
HKD1_k127_1537196_0 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000002684 188.0
HKD1_k127_1545017_0 Belongs to the MCM family K10726 - - 5.954e-245 775.0
HKD1_k127_1545017_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007744 563.0
HKD1_k127_1545017_10 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 - 3.1.1.29 0.000000000000000000000000000000000000006345 147.0
HKD1_k127_1545017_11 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000001169 94.0
HKD1_k127_1545017_12 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000000608 91.0
HKD1_k127_1545017_13 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000000008588 92.0
HKD1_k127_1545017_14 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000007448 80.0
HKD1_k127_1545017_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 484.0
HKD1_k127_1545017_3 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423 413.0
HKD1_k127_1545017_4 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 384.0
HKD1_k127_1545017_5 Domain of unknown function (DUF1743) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 318.0
HKD1_k127_1545017_6 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000002807 236.0
HKD1_k127_1545017_7 pfam nmd3 K07562 - - 0.00000000000000000000000000000000000000000000000000000007804 208.0
HKD1_k127_1545017_8 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000002221 194.0
HKD1_k127_1545017_9 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000156 162.0
HKD1_k127_1559261_0 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 343.0
HKD1_k127_1559261_1 Belongs to the UPF0284 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 321.0
HKD1_k127_1559261_2 Pfam:UPF0118 - - - 0.000000000000000000000000000000719 129.0
HKD1_k127_1559261_3 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000008232 91.0
HKD1_k127_1629530_0 nuclear chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003904 271.0
HKD1_k127_1629530_1 OmpA family - - - 0.0000000000000000000000000000000000000000000000000001678 192.0
HKD1_k127_1629530_3 - - - - 0.000000000000000000000009021 104.0
HKD1_k127_1629530_4 SNF2 family N-terminal domain - - - 0.00000000000000000001001 102.0
HKD1_k127_1636804_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000057 237.0
HKD1_k127_1639503_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 349.0
HKD1_k127_1639503_1 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000004107 250.0
HKD1_k127_1639503_2 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000003948 245.0
HKD1_k127_1639503_3 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000004482 152.0
HKD1_k127_1639503_4 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000000000000009259 81.0
HKD1_k127_1639503_5 Polysaccharide deacetylase - - - 0.0001403 55.0
HKD1_k127_1664173_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 6.083e-202 637.0
HKD1_k127_1664173_1 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006361 492.0
HKD1_k127_1664173_10 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000000002509 209.0
HKD1_k127_1664173_11 CoA-binding domain protein K06929 - - 0.0000000000000000000000000000000000000000000000000001958 188.0
HKD1_k127_1664173_12 Polyprenyl synthetase K02523 GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765 2.5.1.90 0.00000000000000000000000000000000000000000000000000357 192.0
HKD1_k127_1664173_13 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000002634 173.0
HKD1_k127_1664173_14 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000003949 157.0
HKD1_k127_1664173_15 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000001318 154.0
HKD1_k127_1664173_16 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.000000000000000000000000000000000003709 140.0
HKD1_k127_1664173_17 PFAM Cache, type 2 domain protein - - - 0.000000000000000000000000000000001192 133.0
HKD1_k127_1664173_18 transferase hexapeptide K02617,K03321 - - 0.0000000000000000000000000000004215 126.0
HKD1_k127_1664173_19 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.0000000000000000000007101 95.0
HKD1_k127_1664173_2 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 385.0
HKD1_k127_1664173_20 COG0526 Thiol-disulfide isomerase and thioredoxins K03671 - - 0.0000000000000000001405 91.0
HKD1_k127_1664173_21 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.00000000000000003649 82.0
HKD1_k127_1664173_22 - - - - 0.0000000000006403 72.0
HKD1_k127_1664173_23 - - - - 0.000000007847 58.0
HKD1_k127_1664173_3 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 378.0
HKD1_k127_1664173_4 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 366.0
HKD1_k127_1664173_5 Metallo-beta-lactamase superfamily K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 326.0
HKD1_k127_1664173_6 SMART Elongator protein 3 MiaB NifB K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 316.0
HKD1_k127_1664173_7 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 299.0
HKD1_k127_1664173_8 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005699 294.0
HKD1_k127_1664173_9 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000002624 231.0
HKD1_k127_1675996_0 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 410.0
HKD1_k127_1675996_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 372.0
HKD1_k127_1675996_2 Isocitrate lyase family K03417 - 4.1.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 332.0
HKD1_k127_1675996_3 DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002738 278.0
HKD1_k127_1675996_4 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000002642 183.0
HKD1_k127_1690666_0 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000005561 200.0
HKD1_k127_1690666_1 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000000004507 134.0
HKD1_k127_1690666_2 Cupin domain - - - 0.000000232 53.0
HKD1_k127_173396_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008557 534.0
HKD1_k127_173396_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 431.0
HKD1_k127_173396_2 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009265 291.0
HKD1_k127_173396_3 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005083 253.0
HKD1_k127_173396_4 Has ATPase and non-specific DNA-binding activities K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000002561 254.0
HKD1_k127_173396_5 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000002306 244.0
HKD1_k127_173396_6 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000008787 160.0
HKD1_k127_173396_7 Transcriptional regulator, TrmB - - - 0.000000000000000000000000000000000002575 141.0
HKD1_k127_173396_8 - - - - 0.000000000000000000000000000000000007609 147.0
HKD1_k127_173396_9 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.0000000003144 63.0
HKD1_k127_1757514_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000001328 130.0
HKD1_k127_1757514_2 PFAM SOUL heme-binding protein - - - 0.000003652 51.0
HKD1_k127_1757514_3 COG2335, Secreted and surface protein containing fasciclin-like repeats - - - 0.00002496 49.0
HKD1_k127_1757514_4 Nitroreductase - - - 0.0001172 44.0
HKD1_k127_177836_0 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 574.0
HKD1_k127_177836_1 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 432.0
HKD1_k127_177836_2 PFAM ABC transporter related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008767 357.0
HKD1_k127_177836_3 PFAM cobalamin synthesis protein P47K - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 352.0
HKD1_k127_177836_4 PFAM Fe-S cluster domain protein K06939 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001796 255.0
HKD1_k127_177836_5 Domain of unknown function (DUF4870) K09940 - - 0.0000000000000000000000000001964 119.0
HKD1_k127_177836_7 Phosphoserine phosphatase - - - 0.0000000000009138 79.0
HKD1_k127_177836_8 - - - - 0.00000006283 61.0
HKD1_k127_177929_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000002479 102.0
HKD1_k127_181933_0 PFAM PilT protein domain protein K06865 - - 1.915e-212 674.0
HKD1_k127_181933_1 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 404.0
HKD1_k127_181933_2 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 347.0
HKD1_k127_181933_3 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000026 162.0
HKD1_k127_181933_4 - - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464 - 0.00000006674 57.0
HKD1_k127_1850523_0 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008463 557.0
HKD1_k127_1850523_1 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 475.0
HKD1_k127_1850523_2 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000002917 146.0
HKD1_k127_1850523_3 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000000000000000003992 126.0
HKD1_k127_1850523_4 Cysteine-rich small domain K08260 - 3.5.1.90 0.000000000000000000006232 104.0
HKD1_k127_1850523_5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0004277 49.0
HKD1_k127_1887115_0 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000475 500.0
HKD1_k127_1887115_1 Nitrogen regulatory protein P-II K04751 - - 0.00000000000000000000000000000000000004037 145.0
HKD1_k127_1887115_2 Transposase domain (DUF772) K07481 - - 0.000000000000000000001982 95.0
HKD1_k127_1887115_3 transposase activity K07481 - - 0.000000237 53.0
HKD1_k127_1887115_4 Transposase domain (DUF772) K07481 - - 0.0001126 50.0
HKD1_k127_1909031_0 HMGL-like K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003897 536.0
HKD1_k127_1909031_1 PFAM helix-turn-helix HxlR type - - - 0.000000000000000000000000000000000000000000001526 171.0
HKD1_k127_1909031_2 Formylmethanofuran dehydrogenase subunit D K00203 - 1.2.7.12 0.00000000000000000000000001242 113.0
HKD1_k127_1909031_3 Peptidase family M48 K03799 - - 0.00000000000000000000005661 99.0
HKD1_k127_1909031_4 Pyridoxamine 5'-phosphate oxidase - - - 0.00000397 49.0
HKD1_k127_195312_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 558.0
HKD1_k127_195312_1 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000091 267.0
HKD1_k127_195312_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001628 262.0
HKD1_k127_2005035_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.243e-223 706.0
HKD1_k127_2005035_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000000000000000000005328 132.0
HKD1_k127_2005035_2 - - - - 0.0000000000001232 74.0
HKD1_k127_2005873_0 Probable zinc-ribbon domain - - - 0.0000000004921 60.0
HKD1_k127_2016284_0 PFAM ferredoxin-dependent glutamate synthase - - - 1.936e-297 918.0
HKD1_k127_2016284_1 S-layer protein - - - 0.0000000002666 70.0
HKD1_k127_2016284_2 Histidine kinase K07646 - 2.7.13.3 0.000001185 54.0
HKD1_k127_2049082_0 Glycogen debranching enzyme - - - 1.109e-241 750.0
HKD1_k127_2049082_1 Glycogen debranching enzyme - - - 2.711e-225 706.0
HKD1_k127_2049082_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006561 511.0
HKD1_k127_2049082_3 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 287.0
HKD1_k127_2049082_4 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004228 259.0
HKD1_k127_2049082_5 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.000000000000000000000000000000000000000000000003071 183.0
HKD1_k127_2049082_6 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000001153 170.0
HKD1_k127_2049082_7 protein conserved in archaea - - - 0.0000000000000000000000000004665 116.0
HKD1_k127_2049082_8 Transcriptional regulator, TrmB - - - 0.000000000000000000000000005049 115.0
HKD1_k127_2049082_9 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000007994 76.0
HKD1_k127_2178947_0 Belongs to the UPF0288 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008747 338.0
HKD1_k127_2178947_1 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000000149 137.0
HKD1_k127_21953_0 PFAM SMC domain protein K03546 - - 0.000005758 60.0
HKD1_k127_2230474_0 eRF1 domain 2 - - - 0.00000000000000000000000009078 118.0
HKD1_k127_2230474_1 Belongs to the UPF0248 family K09715 - - 0.0000000000000000003344 89.0
HKD1_k127_2230474_2 SOUL heme-binding protein - - - 0.000000000000000005377 91.0
HKD1_k127_2230474_3 PFAM Leucine rich repeat variant - - - 0.0000000001707 71.0
HKD1_k127_223116_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 4.1e-322 1009.0
HKD1_k127_223116_1 MacB-like periplasmic core domain K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 300.0
HKD1_k127_223116_2 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003549 275.0
HKD1_k127_223116_3 nicotinamidase activity - GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009117,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019362,GO:0019637,GO:0019674,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901360,GO:1901564 - 0.0000000000000000000000000000000000000000000000004863 183.0
HKD1_k127_223116_4 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000001548 171.0
HKD1_k127_223116_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000004334 130.0
HKD1_k127_223116_6 Protein of unknown function (DUF3467) - - - 0.0000000000000000000000000001411 119.0
HKD1_k127_223116_7 Universal stress protein family - - - 0.00000000000000000000003446 104.0
HKD1_k127_223116_8 - - - - 0.000000000000000002529 89.0
HKD1_k127_2232998_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000001733 108.0
HKD1_k127_2232998_1 small metal-binding protein - - - 0.0006314 45.0
HKD1_k127_2247586_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 574.0
HKD1_k127_2247586_1 NADH:flavin oxidoreductase / NADH oxidase family K10680 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 506.0
HKD1_k127_2247586_10 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.000000000000001696 78.0
HKD1_k127_2247586_2 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 494.0
HKD1_k127_2247586_3 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 467.0
HKD1_k127_2247586_4 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008852 296.0
HKD1_k127_2247586_5 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008532 292.0
HKD1_k127_2247586_6 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001616 281.0
HKD1_k127_2247586_7 NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001664 241.0
HKD1_k127_2247586_8 PFAM PEBP family protein K06910 - - 0.000000000000000000000000000000000000000000000003466 176.0
HKD1_k127_2247586_9 Rhomboid family K07059 - - 0.000000000000000000000000000000003377 138.0
HKD1_k127_2249209_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000007028 165.0
HKD1_k127_2249209_1 Transposase domain (DUF772) K07481 - - 0.0000000001202 65.0
HKD1_k127_225165_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007869 533.0
HKD1_k127_225165_1 Involved in cell shape control K22222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 415.0
HKD1_k127_225165_10 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000145 121.0
HKD1_k127_225165_11 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000000000000000006959 117.0
HKD1_k127_225165_2 TIGRFAM TraB family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007717 404.0
HKD1_k127_225165_3 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 343.0
HKD1_k127_225165_4 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 336.0
HKD1_k127_225165_5 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007083 317.0
HKD1_k127_225165_6 Serine protease with a broad substrate specificity K13276,K17734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002294 273.0
HKD1_k127_225165_7 PFAM glutamate synthase alpha subunit K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000001656 237.0
HKD1_k127_225165_8 PFAM Class II Aldolase K01628 - 4.1.2.17 0.00000000000000000000000000000000000000001514 159.0
HKD1_k127_225165_9 PFAM periplasmic copper-binding - - - 0.000000000000000000000000000000004485 145.0
HKD1_k127_2267505_0 KH, type 1, domain K07041 - - 1.463e-311 964.0
HKD1_k127_2267505_1 DEAD DEAH box helicase domain protein K03725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 354.0
HKD1_k127_2267505_2 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 329.0
HKD1_k127_2267505_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001333 261.0
HKD1_k127_2267505_4 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000006955 214.0
HKD1_k127_2267505_5 ArsR transcriptional regulator - - - 0.000000000000000000000000000000000000000000000002047 178.0
HKD1_k127_2267505_6 ATPase (PilT family) K06865 - - 0.00000005767 57.0
HKD1_k127_2271459_0 PFAM Chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 597.0
HKD1_k127_2271459_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 574.0
HKD1_k127_2271459_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 579.0
HKD1_k127_2271459_3 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006295 316.0
HKD1_k127_2271459_4 TIGRFAM small GTP-binding protein K06943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 297.0
HKD1_k127_2271459_5 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006021 244.0
HKD1_k127_2271459_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000001125 205.0
HKD1_k127_2271459_7 Protein of unknown function (DUF1699) - - - 0.000000000000000000000000000000000000000004098 158.0
HKD1_k127_2271459_8 PFAM methyltransferase small K02493 - 2.1.1.297 0.00000000000000000000000000000000000000006781 158.0
HKD1_k127_2271459_9 Gar1/Naf1 RNA binding region K07569 - - 0.00000000007411 66.0
HKD1_k127_22911_0 Arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 287.0
HKD1_k127_22911_1 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000241 224.0
HKD1_k127_22911_2 Isoprenylcysteine carboxyl methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000001567 211.0
HKD1_k127_22911_3 Ion channel K10716 - - 0.00000000000000000000000000000000000000000000000000000004872 205.0
HKD1_k127_22911_4 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000006423 204.0
HKD1_k127_22911_5 Domain of unknown function (DUF3786) - - - 0.0000000000000003446 85.0
HKD1_k127_22911_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000006624 74.0
HKD1_k127_2318928_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000000000000000000000000000007146 207.0
HKD1_k127_2318928_1 Domain of Unknown Function (DUF1259) - - - 0.0000000000000000000000000000000000002434 145.0
HKD1_k127_2318928_2 - - - - 0.00000005125 57.0
HKD1_k127_2318928_3 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.00000098 53.0
HKD1_k127_2318928_4 - - - - 0.000002366 53.0
HKD1_k127_2323605_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008506 289.0
HKD1_k127_2323605_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000003284 175.0
HKD1_k127_2323605_2 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000001314 123.0
HKD1_k127_2323605_3 Protein of unknown function (DUF1232) - - - 0.000000000000000000006185 97.0
HKD1_k127_2323605_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.000000000000001984 80.0
HKD1_k127_2323605_5 - - - - 0.0000000000004931 75.0
HKD1_k127_2337204_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 472.0
HKD1_k127_2337204_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009409 287.0
HKD1_k127_2337204_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.0000000000000000000000000000000000000000000000000005247 185.0
HKD1_k127_2343740_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.0 1010.0
HKD1_k127_2343740_1 Cys/Met metabolism PLP-dependent enzyme K01758,K01761 - 4.4.1.1,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009691 475.0
HKD1_k127_2343740_10 Belongs to the 'phage' integrase family - - - 0.00002748 51.0
HKD1_k127_2343740_11 Chagasin family peptidase inhibitor I42 K14475 - - 0.0003153 51.0
HKD1_k127_2343740_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000008456 237.0
HKD1_k127_2343740_3 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000006485 205.0
HKD1_k127_2343740_4 Dihydrouridine synthase (Dus) - - - 0.0000000000000000000000000000000000000000000000000001632 205.0
HKD1_k127_2343740_5 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000003503 125.0
HKD1_k127_2343740_6 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000001837 118.0
HKD1_k127_2343740_7 Hemerythrin HHE cation binding K07322 - - 0.0000000000000000000001463 100.0
HKD1_k127_2343740_8 Dodecin K09165 - - 0.00000000000000000001535 94.0
HKD1_k127_2343740_9 Putative zinc- or iron-chelating domain K06940 - - 0.00000000009101 70.0
HKD1_k127_236746_0 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001404 240.0
HKD1_k127_236746_1 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.000000000000000000000000000001849 133.0
HKD1_k127_236746_2 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000005055 126.0
HKD1_k127_236746_3 PspC domain K03973 - - 0.000000000000000000255 90.0
HKD1_k127_2368078_0 GTP-binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 310.0
HKD1_k127_2368078_1 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.0000000000000000000000000000000000008373 142.0
HKD1_k127_2368078_2 Zn-ribbon containing protein K07163 - - 0.00000000000000000002022 97.0
HKD1_k127_2368078_3 - - - - 0.00000000006319 66.0
HKD1_k127_2368078_4 Mo-molybdopterin cofactor metabolic process K03753 - - 0.00001213 51.0
HKD1_k127_2371883_0 amino acid K02030 - - 0.0000005434 60.0
HKD1_k127_2374193_0 Recombinase - - - 0.0000000000000000000000000000000000000000000000000000005936 202.0
HKD1_k127_2374193_1 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.000000000000000000000000007016 112.0
HKD1_k127_2374193_2 - K01489 - 3.5.4.5 0.000000000000001567 79.0
HKD1_k127_239063_0 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007056 311.0
HKD1_k127_239063_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000002862 151.0
HKD1_k127_2407514_0 PHP C-terminal domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006342 414.0
HKD1_k127_2407514_1 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000009403 243.0
HKD1_k127_2407514_2 Has ATPase and non-specific DNA-binding activities K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000002328 225.0
HKD1_k127_2414772_0 - - - - 0.0000000000000000002048 93.0
HKD1_k127_2414772_1 Protein of unknown function (DUF998) - - - 0.00000000000004751 74.0
HKD1_k127_2463955_0 LOR SDH bifunctional protein conserved domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 506.0
HKD1_k127_2463955_1 RNA ligase K07468 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 357.0
HKD1_k127_2463955_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001629 282.0
HKD1_k127_2463955_3 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007485 269.0
HKD1_k127_2463955_4 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003788 245.0
HKD1_k127_2463955_5 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004843 228.0
HKD1_k127_2463955_6 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000004851 165.0
HKD1_k127_2509500_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 458.0
HKD1_k127_2509500_1 Glycogen debranching enzyme N terminal - - - 0.00007105 46.0
HKD1_k127_2509500_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0004876 49.0
HKD1_k127_2529596_0 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 456.0
HKD1_k127_2529596_1 cellular potassium ion transport K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003447 375.0
HKD1_k127_2529596_2 TIGRFAM F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000115 274.0
HKD1_k127_2529596_3 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000004857 239.0
HKD1_k127_2529596_4 Belongs to the LarC family K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000003892 167.0
HKD1_k127_2529596_5 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000006848 133.0
HKD1_k127_256714_0 PFAM glycoside hydrolase 15-related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001101 249.0
HKD1_k127_256714_1 4Fe-4S dicluster domain - - - 0.00000000000000000307 85.0
HKD1_k127_256714_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000009898 83.0
HKD1_k127_2699364_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.00000000000000001503 83.0
HKD1_k127_2707864_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1236.0
HKD1_k127_2707864_1 LUD domain - - - 0.0000000000000000000000000000000000000000000003212 171.0
HKD1_k127_2707864_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000392 75.0
HKD1_k127_2743377_0 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 410.0
HKD1_k127_2743377_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002576 342.0
HKD1_k127_2743377_2 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000521 175.0
HKD1_k127_2743377_3 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.0000002526 55.0
HKD1_k127_27646_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 3.837e-223 706.0
HKD1_k127_27646_1 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 353.0
HKD1_k127_27646_2 signal transduction protein with CBS domains K07744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 293.0
HKD1_k127_27646_3 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 283.0
HKD1_k127_27646_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000003884 213.0
HKD1_k127_27646_5 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.00000000000000000000000000000000000000000000000000000000374 203.0
HKD1_k127_27646_6 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000005449 175.0
HKD1_k127_27646_7 phytol kinase activity K16368 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576 2.7.1.174 0.0000000005604 68.0
HKD1_k127_2797639_0 PFAM Cache, type 2 domain protein - - - 0.0000000000000000000000000000000000000001068 158.0
HKD1_k127_2797639_1 - - - - 0.000000000000000734 82.0
HKD1_k127_2817163_0 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006399 486.0
HKD1_k127_2817163_1 Protein of unknown function (DUF763) K09003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008134 470.0
HKD1_k127_2817163_2 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000619 205.0
HKD1_k127_2817163_3 membrane - - - 0.0000000000000000000000000000000000001366 151.0
HKD1_k127_2817163_4 Alpha/beta hydrolase family - GO:0003674,GO:0003824,GO:0016787 - 0.000000000000000000000000000000001491 135.0
HKD1_k127_2817163_5 RDD family - - - 0.00000000000000000005764 95.0
HKD1_k127_2855274_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 428.0
HKD1_k127_2855274_1 HTH-type transcriptional regulatory protein K07728 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004563 286.0
HKD1_k127_2855274_2 PFAM Phosphoribulokinase uridine kinase K00855 - 2.7.1.19 0.000000000000000034 82.0
HKD1_k127_2855274_3 PFAM Phosphoribulokinase uridine kinase K00855 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19 0.00000000000002274 78.0
HKD1_k127_2855274_4 - - - - 0.000000001775 61.0
HKD1_k127_2890569_0 PFAM peptidase M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006586 286.0
HKD1_k127_2890569_1 PFAM glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000003115 151.0
HKD1_k127_2890569_2 Dodecin K09165 - - 0.000000000000000815 78.0
HKD1_k127_2928668_0 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004475 266.0
HKD1_k127_2928668_1 Lrp/AsnC ligand binding domain - - - 0.00000002264 59.0
HKD1_k127_2928668_2 - - - - 0.000001346 56.0
HKD1_k127_297208_0 PFAM Cation K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 366.0
HKD1_k127_297208_1 Bacterial protein of unknown function (DUF922) - - - 0.00000000000133 76.0
HKD1_k127_3029909_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 421.0
HKD1_k127_3029909_1 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005991 248.0
HKD1_k127_3029909_2 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000003132 165.0
HKD1_k127_3029909_3 - - - - 0.0000000000000000001106 99.0
HKD1_k127_3034720_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1417.0
HKD1_k127_3034720_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 5.019e-236 757.0
HKD1_k127_3034720_2 PFAM AIR synthase related protein K07388 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 556.0
HKD1_k127_3034720_3 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 393.0
HKD1_k127_3034720_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 321.0
HKD1_k127_3034720_5 Major facilitator superfamily - - - 0.00000000000000000000000000000000002824 149.0
HKD1_k127_3034720_6 Protein of unknown function (DUF3467) - - - 0.0000000000000000000000000000001798 126.0
HKD1_k127_3034720_7 TPR repeat-containing protein - - - 0.00000000000000000001476 98.0
HKD1_k127_3034720_8 Lrp/AsnC ligand binding domain - - - 0.000000000000005662 77.0
HKD1_k127_3037866_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 479.0
HKD1_k127_3037866_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 405.0
HKD1_k127_3037866_10 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000003274 105.0
HKD1_k127_3037866_11 COG3634 Alkyl hydroperoxide reductase, large subunit - - - 0.000000000000000003056 86.0
HKD1_k127_3037866_12 Ribosomal protein S27E K02978 - - 0.000000000000000003396 85.0
HKD1_k127_3037866_13 protein conserved in archaea K09723 - - 0.00000000000000007055 88.0
HKD1_k127_3037866_14 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000001151 68.0
HKD1_k127_3037866_15 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000001129 57.0
HKD1_k127_3037866_2 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 334.0
HKD1_k127_3037866_3 Translation initiation factor 2 alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 312.0
HKD1_k127_3037866_4 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 311.0
HKD1_k127_3037866_5 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 307.0
HKD1_k127_3037866_6 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 298.0
HKD1_k127_3037866_7 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 288.0
HKD1_k127_3037866_8 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007381 282.0
HKD1_k127_3037866_9 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000001005 134.0
HKD1_k127_3045303_0 AAA-like domain K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 497.0
HKD1_k127_3045303_1 TGS domain protein K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 484.0
HKD1_k127_3045303_10 - - - - 0.0000000000000000000000000000000000000000001826 172.0
HKD1_k127_3045303_11 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000001807 153.0
HKD1_k127_3045303_12 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000001868 130.0
HKD1_k127_3045303_13 Serine dehydrogenase proteinase - - - 0.00000000000005642 75.0
HKD1_k127_3045303_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 426.0
HKD1_k127_3045303_3 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003804 378.0
HKD1_k127_3045303_4 PFAM peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 374.0
HKD1_k127_3045303_5 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 310.0
HKD1_k127_3045303_6 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 302.0
HKD1_k127_3045303_7 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 297.0
HKD1_k127_3045303_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001103 287.0
HKD1_k127_3045303_9 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441,K22174 - 1.1.98.4,1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000009007 250.0
HKD1_k127_3074616_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007538 437.0
HKD1_k127_3074616_1 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000001417 205.0
HKD1_k127_3074616_2 - - - - 0.0000000000000000000000000000000000000003256 165.0
HKD1_k127_3074616_3 Domain of unknown function DUF123 - - - 0.00000000000000000000000000009539 119.0
HKD1_k127_3074616_4 Domain of unknown function DUF11 - - - 0.00000000002397 78.0
HKD1_k127_3075047_0 PFAM Radical SAM domain protein K06871 - - 1.731e-195 615.0
HKD1_k127_3075047_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003972 351.0
HKD1_k127_3075047_2 Uncharacterised conserved protein (DUF2156) K01163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001063 261.0
HKD1_k127_3075047_3 von Willebrand factor, type A K07114 - - 0.0000005641 61.0
HKD1_k127_3082683_0 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 300.0
HKD1_k127_3082683_1 5'(3')-deoxyribonucleotidase - - - 0.00000000008465 70.0
HKD1_k127_3082683_2 polyketide synthase K00665 GO:0003674,GO:0003824,GO:0004312,GO:0005975,GO:0005976,GO:0005977,GO:0006073,GO:0006082,GO:0006091,GO:0006112,GO:0006629,GO:0006631,GO:0006633,GO:0006638,GO:0006639,GO:0006641,GO:0006723,GO:0007275,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009743,GO:0009744,GO:0009987,GO:0010033,GO:0015980,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0019752,GO:0032501,GO:0032502,GO:0032787,GO:0034285,GO:0042221,GO:0042335,GO:0043170,GO:0043436,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0045017,GO:0046394,GO:0046460,GO:0046463,GO:0046486,GO:0048856,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071322,GO:0071324,GO:0071329,GO:0071704,GO:0072330,GO:0097089,GO:1901576,GO:1901700,GO:1901701,GO:1902321 2.3.1.85 0.0004512 44.0
HKD1_k127_3108717_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 7.675e-204 659.0
HKD1_k127_3108717_1 Transposase domain (DUF772) K07481 - - 0.00000000003381 66.0
HKD1_k127_3108717_2 Transposase domain (DUF772) K07481 - - 0.00000004992 58.0
HKD1_k127_3108717_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0008483 42.0
HKD1_k127_3115504_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 581.0
HKD1_k127_3115504_1 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000001488 186.0
HKD1_k127_3115504_2 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000001096 201.0
HKD1_k127_3115504_3 transcription activator, effector binding - - - 0.00000000000000000000000000000000000000001769 157.0
HKD1_k127_3115504_4 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000000000000000000000000000000006927 157.0
HKD1_k127_3115504_5 Bacterial PH domain - - - 0.0000000000000000000000000000008669 126.0
HKD1_k127_3115504_6 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.000000000000000000009179 96.0
HKD1_k127_3115504_7 PFAM TM2 domain containing protein K03686 - - 0.0000000000000000002394 91.0
HKD1_k127_3115504_8 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000004926 74.0
HKD1_k127_3117720_0 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000008198 204.0
HKD1_k127_3117720_1 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000007083 187.0
HKD1_k127_3117720_2 Uncharacterised conserved protein (DUF2156) K01163 - - 0.0000000000000000000000000000000000000000003131 161.0
HKD1_k127_3117720_3 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.0000000000001341 79.0
HKD1_k127_3117720_4 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000002811 61.0
HKD1_k127_3129691_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 434.0
HKD1_k127_3129691_1 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 307.0
HKD1_k127_3129691_2 Serine dehydrogenase proteinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 286.0
HKD1_k127_3129691_3 Methyltransferase K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005039 284.0
HKD1_k127_3129691_4 PFAM GHMP kinase K06982 - 2.7.1.169 0.000000000000000000000000000000000000000000000000000000000000000002551 235.0
HKD1_k127_3129691_5 Evidence 4 Homologs of previously reported genes of - - - 0.00000000005943 69.0
HKD1_k127_3133736_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 421.0
HKD1_k127_3133736_1 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008566 346.0
HKD1_k127_3133736_2 Methanogenesis marker protein 8 - - - 0.0000000000000000000000000000000000000000000000000000007774 203.0
HKD1_k127_3133736_3 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000003518 188.0
HKD1_k127_3133736_4 TIGRFAM DJ-1 family protein K03152 - 3.5.1.124 0.000000000000000000000000000000000000000000004188 169.0
HKD1_k127_3133736_5 Transposase domain (DUF772) K07481 - - 0.00000000000000000000001617 104.0
HKD1_k127_3133736_6 Transposase domain (DUF772) K07481 - - 0.0000000000000000001967 92.0
HKD1_k127_3133736_7 Transposase domain (DUF772) K07481 - - 0.0000000000000001001 82.0
HKD1_k127_3137596_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 478.0
HKD1_k127_3137596_1 Alkyl sulfatase dimerisation - - - 0.000000000000169 74.0
HKD1_k127_3137596_2 methyltransferase - - - 0.0000002875 54.0
HKD1_k127_3137596_3 Alkyl sulfatase dimerisation - - - 0.0005102 43.0
HKD1_k127_3140250_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 3.285e-294 920.0
HKD1_k127_3140250_1 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 416.0
HKD1_k127_3140250_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 347.0
HKD1_k127_3140250_3 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 345.0
HKD1_k127_3140250_4 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.0000000000000000000003616 97.0
HKD1_k127_3171450_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 490.0
HKD1_k127_3171450_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000007426 77.0
HKD1_k127_3181923_0 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000001621 193.0
HKD1_k127_3206439_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 439.0
HKD1_k127_3206439_1 Threonine synthase N terminus K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008974 337.0
HKD1_k127_3206439_2 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 313.0
HKD1_k127_3206439_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001027 271.0
HKD1_k127_3206439_4 Protein of unknown function (DUF1699) - - - 0.000000000000000000000000000000000000000007654 158.0
HKD1_k127_3206439_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000575 90.0
HKD1_k127_3206439_6 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.000000000000000003523 87.0
HKD1_k127_3252612_0 CHAT domain K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002009 297.0
HKD1_k127_3252612_1 mannose-ethanolamine phosphotransferase activity - - - 0.0000000000000000000000000000000000000002831 171.0
HKD1_k127_3252612_2 serine-type aminopeptidase activity K02030,K14475 - - 0.0005078 53.0
HKD1_k127_3298369_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 535.0
HKD1_k127_3298369_1 PFAM peptidase M42 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 435.0
HKD1_k127_3298369_2 shikimate kinase activity K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 311.0
HKD1_k127_3298369_3 Lycopene cyclase protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 311.0
HKD1_k127_3298369_4 Hydroxymethylglutaryl-CoA reductase, degradative K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000003442 167.0
HKD1_k127_3298369_5 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000001398 168.0
HKD1_k127_3298369_6 Protein of unknown function (DUF1699) - - - 0.00000000000000000000000000000000000006317 146.0
HKD1_k127_3298369_7 Universal stress protein - - - 0.00000000000000000002544 96.0
HKD1_k127_3298369_8 chorismate mutase K04093 - 5.4.99.5 0.00000000000000001587 86.0
HKD1_k127_3298369_9 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.000000000000941 68.0
HKD1_k127_3300492_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K04088,K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000004506 239.0
HKD1_k127_3303944_0 Radical SAM ThiC family K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 446.0
HKD1_k127_3303944_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000003783 177.0
HKD1_k127_3303944_2 - - - - 0.000000002982 68.0
HKD1_k127_3304093_0 PFAM alpha amylase catalytic region - - - 6.29e-266 831.0
HKD1_k127_3304093_1 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 475.0
HKD1_k127_3304093_10 Arsenite-activated ATPase ArsA K01551 - 3.6.3.16 0.00000000000000000000000000000000002956 146.0
HKD1_k127_3304093_11 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000007587 125.0
HKD1_k127_3304093_12 Ammonium Transporter K03320 - - 0.00000000000000001968 84.0
HKD1_k127_3304093_13 - - - - 0.00000000000000002124 85.0
HKD1_k127_3304093_14 TPR repeat-containing protein - - - 0.0000001286 56.0
HKD1_k127_3304093_15 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0001746 44.0
HKD1_k127_3304093_2 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000931 331.0
HKD1_k127_3304093_3 PFAM sodium calcium exchanger membrane region K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 317.0
HKD1_k127_3304093_4 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001187 277.0
HKD1_k127_3304093_5 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001078 270.0
HKD1_k127_3304093_6 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001416 272.0
HKD1_k127_3304093_7 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005051 264.0
HKD1_k127_3304093_8 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000055 237.0
HKD1_k127_3304093_9 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000009522 158.0
HKD1_k127_335703_0 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 307.0
HKD1_k127_335703_1 phosphoesterase RecJ domain protein K15986 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001146 283.0
HKD1_k127_335703_2 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000002803 247.0
HKD1_k127_335703_3 PFAM thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000006869 162.0
HKD1_k127_335703_4 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.00000000000000004017 85.0
HKD1_k127_3365586_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 404.0
HKD1_k127_3365586_1 C-terminal region of MMR_HSR1 domain K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009671 396.0
HKD1_k127_3382724_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002511 249.0
HKD1_k127_3382724_1 CBS domain - - - 0.00000001867 63.0
HKD1_k127_3385151_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 6.525e-203 647.0
HKD1_k127_3385151_1 RibD C-terminal domain - - - 0.00000000000004329 74.0
HKD1_k127_3404750_0 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 289.0
HKD1_k127_3404750_1 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006206 273.0
HKD1_k127_3404750_2 Protein of unknown function (DUF434) - - - 0.0000000000125 68.0
HKD1_k127_342611_0 COG2897 Rhodanese-related sulfurtransferase - - - 0.0000000000000000002773 102.0
HKD1_k127_342611_1 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000001196 94.0
HKD1_k127_342611_2 - - - - 0.0000000004533 64.0
HKD1_k127_3434283_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 523.0
HKD1_k127_3434283_1 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 486.0
HKD1_k127_3434283_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000002386 204.0
HKD1_k127_3444346_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000002643 190.0
HKD1_k127_3465689_0 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006175 324.0
HKD1_k127_3465689_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000001161 124.0
HKD1_k127_3465689_2 STAS domain K04749 - - 0.000000000000000000005388 96.0
HKD1_k127_3482798_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 558.0
HKD1_k127_3482798_1 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.00000000000000000000000002812 111.0
HKD1_k127_3534702_0 NnrU protein K21310 - 2.1.1.334 0.000000000000000000000000000000000000000000000000006375 187.0
HKD1_k127_3534702_1 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000000000000002472 138.0
HKD1_k127_3534702_2 Glutaredoxin - - - 0.0000000000000000000000000000001909 124.0
HKD1_k127_3534702_3 Psort location Cytoplasmic, score - - - 0.000001436 53.0
HKD1_k127_353768_0 Glyoxalase-like domain K06996 - - 0.0000000000000003553 81.0
HKD1_k127_353768_1 transcriptional regulator - - - 0.0000000001891 63.0
HKD1_k127_353768_2 Glyoxalase-like domain K06996 - - 0.0000000003068 64.0
HKD1_k127_353768_3 PFAM Telomeric repeat-binding factor 2 - - - 0.000003122 55.0
HKD1_k127_3541292_0 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 558.0
HKD1_k127_3541292_1 alpha amylase, catalytic region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001562 249.0
HKD1_k127_354949_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 2.493e-208 666.0
HKD1_k127_354949_1 - - - - 0.0000000008987 62.0
HKD1_k127_3563450_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 543.0
HKD1_k127_3563450_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 463.0
HKD1_k127_3563450_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 421.0
HKD1_k127_3563450_3 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 407.0
HKD1_k127_3563450_4 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000000000000000007197 224.0
HKD1_k127_3563450_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000001324 206.0
HKD1_k127_3563450_6 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000008016 148.0
HKD1_k127_3563450_7 - - - - 0.0000000000000000000000000614 109.0
HKD1_k127_3567087_0 Phytoene dehydrogenase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 430.0
HKD1_k127_3567087_1 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007831 291.0
HKD1_k127_3567087_2 PFAM Cache, type 2 domain protein K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000004683 243.0
HKD1_k127_3567087_3 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000009259 190.0
HKD1_k127_3567087_4 TIGRFAM lycopene cyclase domain K22502 - 5.5.1.19 0.00000000000000000000000000000000000000003819 163.0
HKD1_k127_3567087_5 alkylhydroperoxidase like protein, AhpD family - - - 0.000000000000000000000000004667 113.0
HKD1_k127_3567087_6 ARD/ARD' family K01607 - 4.1.1.44 0.0000000000000000168 86.0
HKD1_k127_3567087_7 Nitroreductase - - - 0.0000000004778 65.0
HKD1_k127_3567087_8 Belongs to the 'phage' integrase family K03733,K04763 - - 0.00000003997 59.0
HKD1_k127_3590527_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 469.0
HKD1_k127_3590527_1 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007187 279.0
HKD1_k127_3590527_2 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000001249 101.0
HKD1_k127_3592029_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 7.949e-196 620.0
HKD1_k127_3592029_1 ATP-grasp domain K06914 - 6.3.4.24 0.000000000000000000000000000000000000000000000000000000000000000006091 236.0
HKD1_k127_3592029_2 Stage II sporulation protein M K06384 - - 0.00000000000000000000000000001201 125.0
HKD1_k127_3609720_0 PFAM alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.0000000000000000000000001263 108.0
HKD1_k127_3661104_0 PFAM peptidase - - - 0.000000000000005897 76.0
HKD1_k127_3661104_1 PFAM peptidase - - - 0.0000000004657 60.0
HKD1_k127_3661104_2 Uncharacterized conserved protein (DUF2299) - - - 0.000000001428 59.0
HKD1_k127_3661104_3 PFAM peptidase - - - 0.000003876 52.0
HKD1_k127_3661104_4 Peptidase family M50 - - - 0.00008558 47.0
HKD1_k127_366187_0 PFAM flavin reductase domain protein, FMN-binding - - - 0.0000000000000000000000000000000000000000000000000000000000001079 216.0
HKD1_k127_366187_1 flavin reductase - - - 0.000000006023 57.0
HKD1_k127_3686106_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 553.0
HKD1_k127_3686106_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 399.0
HKD1_k127_3686106_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000533 336.0
HKD1_k127_3686106_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000001641 192.0
HKD1_k127_3686106_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000003538 174.0
HKD1_k127_3686106_5 PUA domain containing protein K07398 - - 0.000000000000000000000000000000000000000000005477 168.0
HKD1_k127_3686106_6 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000009367 96.0
HKD1_k127_3686106_7 Transposase IS116/IS110/IS902 family - - - 0.000000000000000002454 89.0
HKD1_k127_3686106_8 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.0000000000000000217 89.0
HKD1_k127_3689637_0 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 298.0
HKD1_k127_3689637_1 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001268 274.0
HKD1_k127_3689637_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000506 183.0
HKD1_k127_3689637_3 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000007609 113.0
HKD1_k127_3689637_4 - - - - 0.000000007248 62.0
HKD1_k127_3689637_5 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000001066 53.0
HKD1_k127_3689637_6 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.000001029 52.0
HKD1_k127_371722_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000007508 120.0
HKD1_k127_371722_1 response to heat - - - 0.0000000000002151 71.0
HKD1_k127_371722_2 response to heat - - - 0.0000000005811 60.0
HKD1_k127_371722_3 - - - - 0.0000001641 56.0
HKD1_k127_375773_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 1.343e-264 829.0
HKD1_k127_375773_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 5.534e-240 759.0
HKD1_k127_375773_2 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 486.0
HKD1_k127_375773_3 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000001048 144.0
HKD1_k127_375773_4 Voltage gated chloride channel - - - 0.000000000000000000000000000004064 122.0
HKD1_k127_375773_5 PFAM TM2 domain containing protein K03686 - - 0.0000000000000000001117 92.0
HKD1_k127_375773_6 tetratricopeptide repeat - - - 0.0000000000001665 77.0
HKD1_k127_375773_7 transposase activity - - - 0.0000001158 55.0
HKD1_k127_375773_8 transposase activity - - - 0.00001866 48.0
HKD1_k127_375773_9 Lrp/AsnC ligand binding domain - - - 0.0004857 43.0
HKD1_k127_3776511_0 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000002954 119.0
HKD1_k127_3776511_1 - - - - 0.0000000000003201 75.0
HKD1_k127_3776511_2 DNA polymerase activity K02319 - 2.7.7.7 0.0000000007297 64.0
HKD1_k127_381475_0 DEAD/H associated K03724 - - 0.0 1112.0
HKD1_k127_381475_1 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000005645 118.0
HKD1_k127_381475_2 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K02030 - - 0.0000003093 52.0
HKD1_k127_384195_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 369.0
HKD1_k127_384195_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000002339 193.0
HKD1_k127_384195_2 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000009616 158.0
HKD1_k127_3845905_0 Transcriptional regulator K07722 - - 0.00000000000000000000000000000000000000000000000000000000000000007086 224.0
HKD1_k127_3845905_1 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000000000000000000000000000000000009453 203.0
HKD1_k127_3845905_2 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000001723 162.0
HKD1_k127_3845905_3 - - - - 0.000000000000000000000000000000000000001745 153.0
HKD1_k127_3845905_4 SMART Elongator protein 3 MiaB NifB K06936 - - 0.000006434 48.0
HKD1_k127_3845905_5 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.0002934 48.0
HKD1_k127_386413_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 470.0
HKD1_k127_386413_1 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007846 251.0
HKD1_k127_386413_2 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.000000000000000000000000000002474 121.0
HKD1_k127_386413_3 H subunit K02107 - - 0.00000003929 59.0
HKD1_k127_3879165_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 316.0
HKD1_k127_3879165_1 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 291.0
HKD1_k127_3879165_2 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000104 259.0
HKD1_k127_3879165_3 Transposase domain (DUF772) K07481 - - 0.0000000000000000000000000000000000000126 147.0
HKD1_k127_3879165_4 metal ion binding - - - 0.00000000000000000000000001046 115.0
HKD1_k127_3879165_5 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000001066 100.0
HKD1_k127_3879165_6 Periplasmic copper-binding protein (NosD) K07218 - - 0.00000000002008 76.0
HKD1_k127_3879165_7 - - - - 0.00000251 59.0
HKD1_k127_3893880_0 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000803 250.0
HKD1_k127_3893880_1 - - - - 0.00006916 51.0
HKD1_k127_3920291_0 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007059 328.0
HKD1_k127_3920291_1 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007383 245.0
HKD1_k127_3920291_2 PFAM ribonuclease II K01147 - 3.1.13.1 0.000000000000000000000000000000000000000000000000000000002366 207.0
HKD1_k127_3920291_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.000000000000000000000000001173 113.0
HKD1_k127_3920291_4 - - - - 0.0000000000000000000000002714 107.0
HKD1_k127_3920291_5 PFAM ribonuclease II K01147 - 3.1.13.1 0.00000000000000000001844 94.0
HKD1_k127_3920291_7 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.0001315 44.0
HKD1_k127_39538_0 PFAM Radical SAM domain protein K07129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 348.0
HKD1_k127_39538_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000005082 265.0
HKD1_k127_39538_2 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000000000003962 141.0
HKD1_k127_39538_3 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000006085 82.0
HKD1_k127_3982779_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008481 548.0
HKD1_k127_3982779_1 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 389.0
HKD1_k127_3982779_2 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000001203 198.0
HKD1_k127_3982779_3 Belongs to the UPF0288 family - - - 0.000000000000000000000000000000000000000000000000007569 186.0
HKD1_k127_3982779_4 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.00000000000000000000000000000000003083 139.0
HKD1_k127_3982779_5 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.00000000000000000000000000000003844 132.0
HKD1_k127_3982779_6 Carboxymuconolactone decarboxylase family - - - 0.0006648 44.0
HKD1_k127_4003504_0 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 296.0
HKD1_k127_4003504_1 Hit family K19710 - 2.7.7.53 0.000000000000000000000000000000000000000000000000000000000000001608 220.0
HKD1_k127_4003504_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000001616 224.0
HKD1_k127_4003504_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000002619 194.0
HKD1_k127_4003504_4 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000000003244 174.0
HKD1_k127_4003504_5 signal transduction protein with CBS domains - - - 0.0000000000000000000000000000000000000000491 158.0
HKD1_k127_4003504_6 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000000000003736 126.0
HKD1_k127_4003504_7 PFAM CBS domain - - - 0.0000000000000000000000000000001401 128.0
HKD1_k127_404249_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 386.0
HKD1_k127_404249_1 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000000000004729 226.0
HKD1_k127_4043585_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 2.144e-238 749.0
HKD1_k127_4043585_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 1.77e-203 644.0
HKD1_k127_4043585_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000001751 260.0
HKD1_k127_4043585_3 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000005184 208.0
HKD1_k127_4053493_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008654 455.0
HKD1_k127_4053493_1 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 398.0
HKD1_k127_4053493_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 368.0
HKD1_k127_4053493_3 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009041 365.0
HKD1_k127_4053493_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 304.0
HKD1_k127_4053493_5 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 297.0
HKD1_k127_4053493_6 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000001041 220.0
HKD1_k127_4053493_7 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000004496 206.0
HKD1_k127_4053493_8 Belongs to the TrpF family K01696,K01817 - 4.2.1.20,5.3.1.24 0.00000000000000000000000000000000000006442 150.0
HKD1_k127_4053493_9 PFAM PQ loop repeat K15383 - - 0.0000000000005771 73.0
HKD1_k127_4061494_0 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 394.0
HKD1_k127_4061494_1 PFAM Iron-containing alcohol dehydrogenase K00001,K13954 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 370.0
HKD1_k127_4061494_10 NADPH-dependent FMN reductase - - - 0.00000000000155 69.0
HKD1_k127_4061494_2 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009047 368.0
HKD1_k127_4061494_3 Nadph-dependent fmn reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 286.0
HKD1_k127_4061494_4 Iron-containing alcohol dehydrogenase K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000005256 241.0
HKD1_k127_4061494_5 PFAM helix-turn-helix HxlR type - - - 0.0000000000000000000000000000000000000000000000000000000000000003389 221.0
HKD1_k127_4061494_6 Cyclophilin-like K09143 - - 0.000000000000000000000000000000000006298 140.0
HKD1_k127_4061494_7 response to heat - - - 0.00000000000000000000000000004068 119.0
HKD1_k127_4061494_8 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000001626 108.0
HKD1_k127_4061494_9 PFAM nuclease (SNase domain protein) - - - 0.0000000000000000001949 93.0
HKD1_k127_4067821_0 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 462.0
HKD1_k127_4067821_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 432.0
HKD1_k127_4067821_2 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 314.0
HKD1_k127_4067821_3 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000003762 259.0
HKD1_k127_4067821_4 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000003057 244.0
HKD1_k127_4067821_5 Ferritin-like domain K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000000007793 183.0
HKD1_k127_4067821_6 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000000007858 103.0
HKD1_k127_4067821_7 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000000001502 99.0
HKD1_k127_4067821_8 Protein of unknown function (DUF2953) - - - 0.00000000000000001026 91.0
HKD1_k127_4077976_0 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006084 505.0
HKD1_k127_4077976_1 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000006221 225.0
HKD1_k127_4077976_2 binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000002305 217.0
HKD1_k127_4077976_3 Copper amine oxidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000003081 184.0
HKD1_k127_4077976_4 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000719 109.0
HKD1_k127_4077976_5 Copper amine oxidase N-terminal domain - - - 0.00000000000001386 74.0
HKD1_k127_4085713_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00018 - 1.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 452.0
HKD1_k127_4085713_1 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000000001614 62.0
HKD1_k127_4099874_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000003756 221.0
HKD1_k127_4099874_1 Peptidase C39 family K06992 - - 0.000000000000000000000000000000000004245 151.0
HKD1_k127_4099874_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000005895 104.0
HKD1_k127_4102160_0 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006958 448.0
HKD1_k127_4102160_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000001679 90.0
HKD1_k127_4102463_0 ATP synthase alpha/beta chain, C terminal domain K02111 - 3.6.3.14 4.884e-203 644.0
HKD1_k127_4102463_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 534.0
HKD1_k127_4102463_2 ATP synthase K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 298.0
HKD1_k127_4102463_3 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000166 220.0
HKD1_k127_4102463_4 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000004537 208.0
HKD1_k127_4102463_5 - - - - 0.0000000000000000000000000000000000000000000002882 170.0
HKD1_k127_4102463_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000002581 81.0
HKD1_k127_4103774_0 Uncharacterized conserved protein (DUF2196) - - - 0.000000000000000009756 84.0
HKD1_k127_4109587_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 7.799e-206 664.0
HKD1_k127_4109587_1 Peptidase C13 family - - - 0.000000007377 62.0
HKD1_k127_4127363_0 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004831 557.0
HKD1_k127_4127363_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007715 531.0
HKD1_k127_4127363_2 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.0000000000000000003484 94.0
HKD1_k127_4197855_0 PFAM Cache, type 2 domain protein - - - 0.0000000000000000504 85.0
HKD1_k127_4197855_1 PFAM Cache, type 2 domain protein K02030 - - 0.0000000000000001426 81.0
HKD1_k127_4197855_2 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids K04763 - - 0.00000000000002694 78.0
HKD1_k127_4197855_3 PFAM Cache, type 2 domain protein K02030 - - 0.000000000000134 72.0
HKD1_k127_4197855_4 - - - - 0.0000000000001503 75.0
HKD1_k127_4220994_0 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 1.162e-249 777.0
HKD1_k127_4220994_1 PFAM Glutamine amidotransferase, class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000521 457.0
HKD1_k127_4220994_2 GXGXG motif - - - 0.00000001332 57.0
HKD1_k127_4221142_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 476.0
HKD1_k127_4221142_1 SMART zinc finger, CDGSH-type domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 456.0
HKD1_k127_4221142_2 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000002056 216.0
HKD1_k127_4221142_3 domain, Protein K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000006817 182.0
HKD1_k127_4221142_4 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.0000000000005062 70.0
HKD1_k127_4221142_5 - - - - 0.000006658 50.0
HKD1_k127_4226318_0 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - 0.00000000000000000000000000000000001712 140.0
HKD1_k127_4238077_0 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 325.0
HKD1_k127_4238077_1 Putative TM nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000001677 213.0
HKD1_k127_4238077_2 - - - - 0.0000000000000000000000000000000005767 138.0
HKD1_k127_4238077_3 PDGLE domain K02007,K02009 - - 0.00000000000000000000000000000001247 129.0
HKD1_k127_4243128_0 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000001511 97.0
HKD1_k127_424574_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 518.0
HKD1_k127_424574_1 phosphoribosyltransferase K07100 - - 0.00000000000000000000000000000000000000000000000000000000000282 215.0
HKD1_k127_4276252_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 394.0
HKD1_k127_4276252_1 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000008749 147.0
HKD1_k127_4276252_2 Integral membrane protein DUF106 - - - 0.000000000000000000001602 95.0
HKD1_k127_4276252_3 DDE superfamily endonuclease - - - 0.00000000000000000142 86.0
HKD1_k127_4276252_4 Chagasin family peptidase inhibitor I42 K14475 - - 0.0002886 50.0
HKD1_k127_4281312_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 561.0
HKD1_k127_4281312_1 Ribbon-helix-helix protein, copG family - - - 0.0000000000000000000000000000000000000000000000000000001842 199.0
HKD1_k127_4281312_2 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000005282 153.0
HKD1_k127_4281312_3 4Fe-4S dicluster domain - - - 0.000000000004216 68.0
HKD1_k127_4281312_4 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.00000214 54.0
HKD1_k127_4297296_0 PFAM extracellular solute-binding protein family 3 K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000003357 235.0
HKD1_k127_4297296_1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000001385 233.0
HKD1_k127_4297296_2 PFAM Cache, type 2 domain protein - - - 0.0000000000000000000000000000000000000000005925 162.0
HKD1_k127_4320901_0 acid binding OB-fold tRNA helicase-type K07463 - - 8.087e-274 859.0
HKD1_k127_4320901_1 ATP-grasp domain K06913 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004215 256.0
HKD1_k127_4320901_2 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0000000000000000000000000000000000000000000000000000000000007498 214.0
HKD1_k127_4354167_0 Sulfatase K01130 - 3.1.6.1 1.16e-222 723.0
HKD1_k127_4354167_1 Heat shock 70 kDa protein K04043 - - 4.591e-194 612.0
HKD1_k127_4354167_10 - - - - 0.00001405 48.0
HKD1_k127_4354167_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008202 578.0
HKD1_k127_4354167_3 Iron-sulfur cluster-binding domain K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 571.0
HKD1_k127_4354167_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 370.0
HKD1_k127_4354167_5 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000002797 200.0
HKD1_k127_4354167_6 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.000000000000000000000000000000000000000000003292 172.0
HKD1_k127_4354167_7 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000001224 165.0
HKD1_k127_4354167_8 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000004797 126.0
HKD1_k127_4354167_9 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000000000000000007812 97.0
HKD1_k127_4407533_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 8.522e-302 934.0
HKD1_k127_4407533_1 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 2.718e-235 736.0
HKD1_k127_4407533_10 Formylmethanofuran dehydrogenase subunit D K00203 - 1.2.7.12 0.000000000000000000000702 99.0
HKD1_k127_4407533_12 Transposase domain (DUF772) K07481 - - 0.0004827 44.0
HKD1_k127_4407533_2 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 6.398e-218 689.0
HKD1_k127_4407533_3 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 577.0
HKD1_k127_4407533_4 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 540.0
HKD1_k127_4407533_5 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 507.0
HKD1_k127_4407533_6 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000004234 223.0
HKD1_k127_4407533_7 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000001948 220.0
HKD1_k127_4407533_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0000000000000000000000000000001963 124.0
HKD1_k127_4407533_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000003065 100.0
HKD1_k127_4412895_0 deoxyhypusine monooxygenase activity - - - 0.000000000009173 77.0
HKD1_k127_4413634_0 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009501 465.0
HKD1_k127_4413634_1 PFAM regulatory protein, ArsR - - - 0.0000003269 53.0
HKD1_k127_4414610_0 Carbohydrate phosphorylase K00688,K16153 - 2.4.1.1,2.4.1.11 9.372e-207 657.0
HKD1_k127_4414610_1 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 488.0
HKD1_k127_4414610_10 PFAM Imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000000000000000000000000164 118.0
HKD1_k127_4414610_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 491.0
HKD1_k127_4414610_3 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K02588,K21610 - 1.18.6.1,6.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005684 353.0
HKD1_k127_4414610_4 S-layer protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001375 289.0
HKD1_k127_4414610_5 PFAM Sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000005691 260.0
HKD1_k127_4414610_6 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000291 214.0
HKD1_k127_4414610_7 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000007903 189.0
HKD1_k127_4414610_8 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000005194 166.0
HKD1_k127_4414610_9 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.0000000000000000000000000000002217 127.0
HKD1_k127_4415066_0 TPR Domain containing protein - - - 0.00000000000000000000000000000000000000000008305 169.0
HKD1_k127_4418749_0 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 1.425e-297 938.0
HKD1_k127_4418749_1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 294.0
HKD1_k127_4428650_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 530.0
HKD1_k127_4428650_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000007775 77.0
HKD1_k127_4428650_2 S-layer protein - - - 0.0000000000002637 77.0
HKD1_k127_4429613_0 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0042221,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070482,GO:0070887,GO:0071453,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000000000000003562 80.0
HKD1_k127_4429613_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.000000000000002971 76.0
HKD1_k127_4429613_2 PINc domain ribonuclease K09006 - - 0.0000000000001383 72.0
HKD1_k127_4429613_3 Ferric uptake regulator, Fur family K03711,K09825 GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000374,GO:2001141 - 0.000000000001425 70.0
HKD1_k127_4429613_4 PFAM ribonuclease II K01147 - 3.1.13.1 0.0000000001539 62.0
HKD1_k127_4429613_5 Belongs to the Fur family K09825 - - 0.000000007942 59.0
HKD1_k127_4429613_6 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.00002798 48.0
HKD1_k127_4444805_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1561.0
HKD1_k127_4444805_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1052.0
HKD1_k127_4444805_10 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 314.0
HKD1_k127_4444805_11 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007378 301.0
HKD1_k127_4444805_12 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000012 246.0
HKD1_k127_4444805_13 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000001555 228.0
HKD1_k127_4444805_14 amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000000000000001482 202.0
HKD1_k127_4444805_15 Thioredoxin - - - 0.000000000000000000000000000000000000003251 149.0
HKD1_k127_4444805_16 PFAM ribonuclease H K03469 - 3.1.26.4 0.0000000000000000000000004554 109.0
HKD1_k127_4444805_17 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000001098 110.0
HKD1_k127_4444805_18 PBS lyase HEAT-like repeat - - - 0.0000000000000000114 94.0
HKD1_k127_4444805_19 - - - - 0.00000000000005541 75.0
HKD1_k127_4444805_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 8.841e-234 733.0
HKD1_k127_4444805_20 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000332 70.0
HKD1_k127_4444805_21 PFAM Rubrerythrin - - - 0.000000000009222 65.0
HKD1_k127_4444805_22 Transposase domain (DUF772) K07481 - - 0.0000000002295 64.0
HKD1_k127_4444805_23 membrane - - - 0.000007002 59.0
HKD1_k127_4444805_24 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00002409 48.0
HKD1_k127_4444805_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 2.299e-229 719.0
HKD1_k127_4444805_4 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 610.0
HKD1_k127_4444805_5 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006351 608.0
HKD1_k127_4444805_6 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 479.0
HKD1_k127_4444805_7 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 372.0
HKD1_k127_4444805_8 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 366.0
HKD1_k127_4444805_9 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 341.0
HKD1_k127_4466170_0 - K14986 - 2.7.13.3 0.0000000000000000000000000000000000000001428 159.0
HKD1_k127_4466170_1 - K14986 - 2.7.13.3 0.00000000000000000004642 93.0
HKD1_k127_4466170_2 - K14986 - 2.7.13.3 0.0000000000000004783 83.0
HKD1_k127_4466170_3 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.00000002613 56.0
HKD1_k127_4475883_0 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 9.976e-288 905.0
HKD1_k127_4475883_1 Belongs to the carbohydrate kinase PfkB family. LacC subfamily K16370 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007608 343.0
HKD1_k127_4475883_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001115 274.0
HKD1_k127_4475883_3 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K16305 - 2.2.1.11,4.1.2.13 0.00000000001268 65.0
HKD1_k127_4501201_0 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 285.0
HKD1_k127_4501201_1 COG1252 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000002338 236.0
HKD1_k127_4508647_0 malic enzyme K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 500.0
HKD1_k127_4508647_1 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 460.0
HKD1_k127_4508647_2 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 320.0
HKD1_k127_4508647_3 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005162 318.0
HKD1_k127_4508647_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 292.0
HKD1_k127_4508647_5 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00000000000000000000000000000000000000000000008591 175.0
HKD1_k127_4508647_6 KEOPS complex Cgi121-like subunit K09119 - - 0.000000000000000000003807 99.0
HKD1_k127_4508647_7 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000001697 82.0
HKD1_k127_4573343_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 1.128e-195 621.0
HKD1_k127_4573343_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 505.0
HKD1_k127_4573343_10 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000000003447 151.0
HKD1_k127_4573343_11 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.0000000000000000000000000000003914 131.0
HKD1_k127_4573343_12 Flavodoxin - - - 0.0000000000000000000000001844 111.0
HKD1_k127_4573343_13 PAC2 family K07159 - - 0.0000000000000000000002459 104.0
HKD1_k127_4573343_14 - - - - 0.0000001973 57.0
HKD1_k127_4573343_2 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 381.0
HKD1_k127_4573343_3 Glycosyltransferase 28 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 385.0
HKD1_k127_4573343_4 DNA polymerase beta domain protein region K09717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005398 362.0
HKD1_k127_4573343_5 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005893 259.0
HKD1_k127_4573343_6 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005862 252.0
HKD1_k127_4573343_7 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000002372 182.0
HKD1_k127_4573343_8 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000166 159.0
HKD1_k127_4573343_9 Helix-turn-helix XRE-family like proteins K03627 - - 0.000000000000000000000000000000000000004361 151.0
HKD1_k127_4623643_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 3.84e-217 683.0
HKD1_k127_4623643_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 430.0
HKD1_k127_4623643_2 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000009513 149.0
HKD1_k127_4623643_3 pyridoxamine 5'-phosphate oxidase-related FMN-binding K07005 - - 0.000000000000001849 81.0
HKD1_k127_4637045_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000161 175.0
HKD1_k127_4637045_1 - - - - 0.000000007223 59.0
HKD1_k127_4644989_0 COG2217 Cation transport ATPase K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008125 317.0
HKD1_k127_4644989_1 Ferredoxin K05337 - - 0.000000000000000002332 87.0
HKD1_k127_4644989_2 - - - - 0.00000000000008175 76.0
HKD1_k127_4644989_3 YHS domain - - - 0.000000000001993 68.0
HKD1_k127_4644989_4 Short C-terminal domain K08982 - - 0.0000368 49.0
HKD1_k127_4661345_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 516.0
HKD1_k127_4661345_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.0000000000000000000000000000000000000001656 153.0
HKD1_k127_4661345_2 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000000009366 96.0
HKD1_k127_4661345_3 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000009476 84.0
HKD1_k127_4661598_0 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 313.0
HKD1_k127_4661598_1 Domain of Unknown Function (DUF1259) - - - 0.00000000000000000000000000000000000000000000000002882 186.0
HKD1_k127_4662723_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 284.0
HKD1_k127_4662723_1 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000002644 232.0
HKD1_k127_4662723_2 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000008839 193.0
HKD1_k127_4662723_3 - - - - 0.0000007509 53.0
HKD1_k127_4673482_0 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007447 460.0
HKD1_k127_4673482_1 Belongs to the AAA ATPase family K07392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009913 412.0
HKD1_k127_4673482_10 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000000000000000000000000000000085 208.0
HKD1_k127_4673482_11 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000000000000000004749 154.0
HKD1_k127_4673482_12 Belongs to the UPF0216 family K09737 - - 0.0000000000000000009365 91.0
HKD1_k127_4673482_13 - - - - 0.0000000000000001138 85.0
HKD1_k127_4673482_14 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000005861 76.0
HKD1_k127_4673482_2 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 396.0
HKD1_k127_4673482_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007737 385.0
HKD1_k127_4673482_4 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 379.0
HKD1_k127_4673482_5 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 314.0
HKD1_k127_4673482_6 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 287.0
HKD1_k127_4673482_7 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001377 275.0
HKD1_k127_4673482_8 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000006817 268.0
HKD1_k127_4673482_9 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000000000001142 226.0
HKD1_k127_4725867_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 569.0
HKD1_k127_4725867_1 HMGL-like K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 489.0
HKD1_k127_4725867_2 sugar phosphatases of the HAD superfamily K01101,K02566 - 3.1.3.41 0.00000000000000000000000000000000000000000000000001395 185.0
HKD1_k127_4725867_3 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000008633 161.0
HKD1_k127_4725867_4 sugar phosphatases of the HAD superfamily K02566 - - 0.000000001225 62.0
HKD1_k127_4736589_0 PFAM CMP dCMP deaminase zinc-binding K01485 - 3.5.4.1 0.000000000000000000000000000000000000000000000000004008 185.0
HKD1_k127_4736589_1 - - - - 0.00000000000000000000000000000000000000009488 156.0
HKD1_k127_4736589_2 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.000000000000000001343 92.0
HKD1_k127_4736589_3 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.00006612 46.0
HKD1_k127_4764490_0 Peptidase C39 family K06992 - - 0.0000000000000000000000000000000005077 144.0
HKD1_k127_4764490_1 VIT family - - - 0.0000001009 62.0
HKD1_k127_4764490_2 - - - - 0.0005913 44.0
HKD1_k127_4764490_3 Belongs to the Fur family K03711,K09825 - - 0.000958 45.0
HKD1_k127_4781875_0 - - - - 0.00000000000009661 76.0
HKD1_k127_4790334_0 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000009008 251.0
HKD1_k127_4790334_1 K02028 polar amino acid transport system ATP-binding protein K02028 - 3.6.3.21 0.00000000000000000000000000000000000000000611 156.0
HKD1_k127_4790334_2 Saccharopine dehydrogenase - - - 0.0000000000000000000003669 105.0
HKD1_k127_4848817_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 3.52e-196 619.0
HKD1_k127_4848817_1 PFAM AIR synthase related protein K07123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 380.0
HKD1_k127_4848817_2 S-layer protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009844 266.0
HKD1_k127_4848817_3 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000002522 203.0
HKD1_k127_4921136_0 Protein of unknown function, DUF255 K06888 - - 4.616e-194 621.0
HKD1_k127_4921136_1 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000000000000000000000000002717 162.0
HKD1_k127_4921136_2 transposase activity K07481 - - 0.00000000009717 64.0
HKD1_k127_492252_0 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 298.0
HKD1_k127_492252_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000005636 259.0
HKD1_k127_492252_2 Source PGD - - - 0.00000000000000000000000000000000000000000005271 171.0
HKD1_k127_4960185_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 443.0
HKD1_k127_4960185_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 307.0
HKD1_k127_496181_0 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 325.0
HKD1_k127_496181_1 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000002608 198.0
HKD1_k127_5002503_0 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000001069 151.0
HKD1_k127_5002503_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000002828 132.0
HKD1_k127_5002503_2 Uncharacterized conserved protein (DUF2173) - - - 0.000000000000000000000000000002578 122.0
HKD1_k127_5002503_3 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000004512 98.0
HKD1_k127_5002503_4 Protein of unknown function (DUF2769) - - - 0.000000000000000003686 87.0
HKD1_k127_5002503_5 4Fe-4S dicluster domain - - - 0.000000005574 58.0
HKD1_k127_5008840_0 lyase activity - - - 0.00000000000000000000000000000000000005793 162.0
HKD1_k127_5008840_1 - - - - 0.00002065 57.0
HKD1_k127_5042615_0 - - - - 0.0000000000000000000000000000000000000000000000004303 184.0
HKD1_k127_5042615_1 Peptidase family M48 K03799 - - 0.000000000000000000000000000000003878 131.0
HKD1_k127_5042615_2 PFAM CBS domain containing protein - - - 0.0000000000006306 71.0
HKD1_k127_5048296_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.629e-210 662.0
HKD1_k127_5048296_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 287.0
HKD1_k127_5048296_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001281 274.0
HKD1_k127_5048296_3 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.000000000000000000000000000000000000000000002503 167.0
HKD1_k127_5048296_4 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000000000000000000000000000000006674 166.0
HKD1_k127_5048296_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000002002 130.0
HKD1_k127_5048296_6 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.000000000000000000000000000001715 124.0
HKD1_k127_5048296_7 N-ATPase, AtpR subunit - - - 0.00000000000002278 76.0
HKD1_k127_5051951_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 316.0
HKD1_k127_5051951_1 Transcriptional regulator, TrmB - - - 0.000000000000000000000000000000000001878 141.0
HKD1_k127_5061643_0 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 328.0
HKD1_k127_5061643_1 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000004163 198.0
HKD1_k127_5061643_2 - - - - 0.00000000000000000000000000000000001363 139.0
HKD1_k127_5116658_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.588e-222 703.0
HKD1_k127_5116658_1 PFAM Radical SAM domain protein K06937 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 552.0
HKD1_k127_5116658_10 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001684 263.0
HKD1_k127_5116658_11 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000002635 187.0
HKD1_k127_5116658_12 transposition, DNA-mediated - - - 0.00000000000000000000000000000000000000005032 156.0
HKD1_k127_5116658_13 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.0000000000000000000000000000000000001211 150.0
HKD1_k127_5116658_14 binds to the 23S rRNA K02921 - - 0.0000000000000000000000000001621 116.0
HKD1_k127_5116658_15 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.00000000000000000000000005784 113.0
HKD1_k127_5116658_16 RNA binding K07581 - - 0.000000000000000000000009693 107.0
HKD1_k127_5116658_17 Belongs to the UPF0434 family - - - 0.00000000000000000000001334 100.0
HKD1_k127_5116658_18 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.00000000000000000002038 90.0
HKD1_k127_5116658_19 ChaB K06197 - - 0.00000000000007407 75.0
HKD1_k127_5116658_2 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 550.0
HKD1_k127_5116658_20 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000001102 75.0
HKD1_k127_5116658_21 Transposase and inactivated derivatives - - - 0.000000000001617 70.0
HKD1_k127_5116658_22 Transposase and inactivated derivatives K07494 - - 0.000000001481 60.0
HKD1_k127_5116658_23 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.00000343 53.0
HKD1_k127_5116658_24 Histidine kinase K14978 - - 0.00003329 51.0
HKD1_k127_5116658_3 DNA polymerase K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009512 539.0
HKD1_k127_5116658_4 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006687 524.0
HKD1_k127_5116658_5 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 365.0
HKD1_k127_5116658_6 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 338.0
HKD1_k127_5116658_7 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 337.0
HKD1_k127_5116658_8 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 328.0
HKD1_k127_5116658_9 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002153 279.0
HKD1_k127_5119136_0 DEAD DEAH box helicase domain protein K10896 - - 7.491e-228 727.0
HKD1_k127_5119136_1 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 1.024e-211 670.0
HKD1_k127_5119136_10 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000005303 267.0
HKD1_k127_5119136_11 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001888 265.0
HKD1_k127_5119136_12 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009957 266.0
HKD1_k127_5119136_13 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000003619 255.0
HKD1_k127_5119136_14 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000001218 252.0
HKD1_k127_5119136_15 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.000000000000000000000000000000000000000000000000000000000000000004086 231.0
HKD1_k127_5119136_16 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000001639 227.0
HKD1_k127_5119136_17 methyltransferase small K07579 - - 0.000000000000000000000000000000000000000000000000000004608 196.0
HKD1_k127_5119136_18 RNA-binding protein of the translin family K07477 - - 0.0000000000000000000000000000000000000000000000000001773 192.0
HKD1_k127_5119136_19 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000005372 169.0
HKD1_k127_5119136_2 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 527.0
HKD1_k127_5119136_20 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00000000000000000000000000000000000003746 150.0
HKD1_k127_5119136_21 adenyl ribonucleotide binding - - - 0.0000000000000000000002193 103.0
HKD1_k127_5119136_22 - - - - 0.000000000000000001001 94.0
HKD1_k127_5119136_23 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000004175 84.0
HKD1_k127_5119136_24 6-phosphogluconolactonase activity - - - 0.000000000000001048 89.0
HKD1_k127_5119136_25 CHAT domain - - - 0.0000000001887 74.0
HKD1_k127_5119136_26 Transposase domain (DUF772) K07481 - - 0.000000006681 57.0
HKD1_k127_5119136_28 Transposase - - - 0.0000143 51.0
HKD1_k127_5119136_3 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 503.0
HKD1_k127_5119136_4 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 409.0
HKD1_k127_5119136_5 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 397.0
HKD1_k127_5119136_6 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 338.0
HKD1_k127_5119136_7 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 317.0
HKD1_k127_5119136_8 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 287.0
HKD1_k127_5119136_9 PFAM Glutamine cyclotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002102 273.0
HKD1_k127_5131122_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 1.889e-226 717.0
HKD1_k127_5131122_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 544.0
HKD1_k127_5131122_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000003548 217.0
HKD1_k127_5131122_3 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K20881 - 3.1.3.5 0.000000000000000000000000000000000000000000000002421 180.0
HKD1_k127_5131122_4 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000003595 103.0
HKD1_k127_5131122_5 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.00000000000000000001328 93.0
HKD1_k127_5146480_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 584.0
HKD1_k127_5146480_1 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 458.0
HKD1_k127_5146480_10 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000007419 181.0
HKD1_k127_5146480_11 Belongs to the SUI1 family K03113 - - 0.0000000000000000000000000000000000000000001644 161.0
HKD1_k127_5146480_12 B-block binding subunit of TFIIIC - - - 0.000000000000000000000003352 106.0
HKD1_k127_5146480_13 PFAM Like-Sm ribonucleoprotein, core - - - 0.000000000000000000000007467 102.0
HKD1_k127_5146480_14 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000006441 101.0
HKD1_k127_5146480_15 PFAM nitrogen-fixing NifU - - - 0.00000000000000000001208 93.0
HKD1_k127_5146480_16 - - - - 0.0000000000004392 73.0
HKD1_k127_5146480_2 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 398.0
HKD1_k127_5146480_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 367.0
HKD1_k127_5146480_4 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 369.0
HKD1_k127_5146480_5 Transposase domain (DUF772) K07481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 330.0
HKD1_k127_5146480_6 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 337.0
HKD1_k127_5146480_7 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000000000000000000000000000000323 198.0
HKD1_k127_5146480_8 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000000000000000000000000000000000000000000008141 187.0
HKD1_k127_5146480_9 Putative Fe-S cluster K11260 - - 0.00000000000000000000000000000000000000000000000002327 183.0
HKD1_k127_5182309_0 SMART Elongator protein 3 MiaB NifB - - - 1.94e-258 808.0
HKD1_k127_5182309_1 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K16305 - 2.2.1.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 441.0
HKD1_k127_5182309_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 356.0
HKD1_k127_5182309_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009005 306.0
HKD1_k127_5182309_4 Belongs to the glycosyl hydrolase 5 (cellulase A) family K05991 - 3.2.1.123 0.00000000000000000000000000000000000000006716 163.0
HKD1_k127_5223082_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 2.506e-263 822.0
HKD1_k127_5223082_1 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004346 275.0
HKD1_k127_5223082_2 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005587 249.0
HKD1_k127_5223082_3 ABC-3 protein K09816 - - 0.000000000000000000000000000000000000000000000000000000000000000000664 236.0
HKD1_k127_5223082_4 domain protein K01992,K06994 - - 0.0000000000000000000000000000000000000000000000000000001754 205.0
HKD1_k127_5223082_5 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000008058 117.0
HKD1_k127_5223082_6 extracellular matrix structural constituent - - - 0.00000000567 67.0
HKD1_k127_5223378_0 - - - - 0.000000000000000002809 87.0
HKD1_k127_5223378_1 Bacterial periplasmic substrate-binding proteins K02030 - - 0.0000000000000004014 85.0
HKD1_k127_5223378_2 Belongs to the 'phage' integrase family K04763 - - 0.0000005099 54.0
HKD1_k127_5235945_0 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 337.0
HKD1_k127_5235945_1 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001428 254.0
HKD1_k127_5235945_2 ATPases associated with a variety of cellular activities K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000001246 247.0
HKD1_k127_5235945_3 Transcriptional regulator K09714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000003837 103.0
HKD1_k127_5237561_0 PFAM CBS domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000956 482.0
HKD1_k127_5237561_1 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 426.0
HKD1_k127_5237561_2 Glutaredoxin - - - 0.0000000000000000000000000000009001 123.0
HKD1_k127_52482_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 332.0
HKD1_k127_52482_1 protein serine/threonine phosphatase activity K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000007136 256.0
HKD1_k127_52482_2 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000002818 176.0
HKD1_k127_52482_3 Lamin Tail Domain - - - 0.0000000000000004311 84.0
HKD1_k127_52482_4 Protein of unknown function (DUF4064) - - - 0.0002615 48.0
HKD1_k127_5250747_0 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000008982 181.0
HKD1_k127_5250747_1 PFAM Protein kinase domain - - - 0.000000149 59.0
HKD1_k127_5250747_2 YEATS family - - - 0.0001275 51.0
HKD1_k127_5253661_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 5.395e-202 652.0
HKD1_k127_5253661_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005599 374.0
HKD1_k127_5253661_2 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000001861 60.0
HKD1_k127_5260745_0 PFAM Orn Lys Arg decarboxylase major region K01582,K01584 - 4.1.1.18,4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005945 393.0
HKD1_k127_5260745_1 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000006456 183.0
HKD1_k127_5263318_0 - - - - 0.0000000000000000000000000000000000000001122 151.0
HKD1_k127_5263318_1 Ion channel - - - 0.0000000000009558 73.0
HKD1_k127_5275882_0 helicase superfamily c-terminal domain - - - 2.733e-211 663.0
HKD1_k127_5275882_1 Protein of unknown function (DUF790) K09744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 585.0
HKD1_k127_5275882_2 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.00000000000000000000000000001702 126.0
HKD1_k127_5275882_3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000000000000000001617 121.0
HKD1_k127_5275882_4 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0000000000000006209 81.0
HKD1_k127_5275882_5 Protein of unknown function DUF45 K07043 - - 0.00000002971 55.0
HKD1_k127_5281403_0 protein containing SIS (Sugar ISomerase) phosphosugar binding domain - - - 0.0000000000000000000000000000000000000000000000007798 177.0
HKD1_k127_5281403_1 GNAT acetyltransferase - - - 0.000000000000000000000000000002394 130.0
HKD1_k127_5307220_0 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 484.0
HKD1_k127_5314282_0 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 413.0
HKD1_k127_5314282_1 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 311.0
HKD1_k127_5314282_2 Non-histone chromosomal protein MC1 - - - 0.00000000000000000000000000004356 118.0
HKD1_k127_5314282_3 Glyco_18 K01183 - 3.2.1.14 0.000000000000002421 90.0
HKD1_k127_5338353_0 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 295.0
HKD1_k127_5338353_1 Thioredoxin K03671 - - 0.00000000000002085 85.0
HKD1_k127_5338353_2 Belongs to the thioredoxin family K03671 - - 0.0000000000006396 81.0
HKD1_k127_5345100_0 Protein of unknown function DUF262 - - - 0.000000000000000000000000000000000000000000001007 169.0
HKD1_k127_5345100_1 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000001571 132.0
HKD1_k127_5345100_2 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.00000000000000000232 88.0
HKD1_k127_5345100_3 PFAM Cache, type 2 domain protein - - - 0.00000000006714 64.0
HKD1_k127_5345100_4 - - - - 0.00001269 52.0
HKD1_k127_5359180_0 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000000002318 183.0
HKD1_k127_5359180_1 Transposase - - - 0.00000000000000000000004018 102.0
HKD1_k127_5359180_2 Transposase - - - 0.000007168 48.0
HKD1_k127_5368307_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 7.038e-285 889.0
HKD1_k127_5376441_0 - - - - 0.00000000000000000000000000000000000000000000000000000001052 202.0
HKD1_k127_5376441_1 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.0000000000415 64.0
HKD1_k127_5376441_2 PFAM Cache, type 2 domain protein - - - 0.00000006132 53.0
HKD1_k127_5398271_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 569.0
HKD1_k127_5398271_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 441.0
HKD1_k127_5398271_10 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000006429 161.0
HKD1_k127_5398271_11 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000784 167.0
HKD1_k127_5398271_12 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000002313 137.0
HKD1_k127_5398271_13 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000002676 131.0
HKD1_k127_5398271_14 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000008758 121.0
HKD1_k127_5398271_15 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000001412 113.0
HKD1_k127_5398271_16 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000003166 92.0
HKD1_k127_5398271_17 PFAM PRC-barrel domain - - - 0.00000000000000000004769 92.0
HKD1_k127_5398271_18 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000001426 81.0
HKD1_k127_5398271_19 transcription initiation from RNA polymerase II promoter - - - 0.000009839 48.0
HKD1_k127_5398271_2 C-terminal region of MMR_HSR1 domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 421.0
HKD1_k127_5398271_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000008078 228.0
HKD1_k127_5398271_4 Subtilase family K17734 - - 0.0000000000000000000000000000000000000000000000000000000124 227.0
HKD1_k127_5398271_5 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001423 205.0
HKD1_k127_5398271_6 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000003035 191.0
HKD1_k127_5398271_7 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000181 166.0
HKD1_k127_5398271_8 NUDIX domain K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000317 160.0
HKD1_k127_5398271_9 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000004414 156.0
HKD1_k127_5413239_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 365.0
HKD1_k127_5413239_1 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001215 273.0
HKD1_k127_5416201_0 PFAM ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.00000000000000006102 83.0
HKD1_k127_5419905_0 acetyltransferase - - - 0.0000000000000000000000000000003918 130.0
HKD1_k127_5419905_1 - - - - 0.000000000000001962 83.0
HKD1_k127_5419905_2 Uncharacterized conserved protein (DUF2173) - - - 0.0000000000004545 73.0
HKD1_k127_5420184_0 ABC-type metal ion transport system periplasmic component surface adhesin K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007662 263.0
HKD1_k127_5420184_1 Domain of unknown function (DUF1890) - - - 0.00000000000000000000000000000000000000000000000000000000002012 209.0
HKD1_k127_5420184_2 Nitroreductase - - - 0.000000000000000000000000000000000000000000001629 173.0
HKD1_k127_5420184_3 Putative zinc ribbon domain - - - 0.000000000000000005787 86.0
HKD1_k127_5420184_4 SPFH Band 7 PHB domain protein - - - 0.0000000000000007242 87.0
HKD1_k127_5428939_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 574.0
HKD1_k127_5428939_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773,K18779 - 2.4.2.29,2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007448 483.0
HKD1_k127_5428939_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 461.0
HKD1_k127_5428939_3 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000000008089 179.0
HKD1_k127_5428939_4 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.000000000000000000000000000008871 128.0
HKD1_k127_5428939_5 Permease - - - 0.0000000000000000000000002698 119.0
HKD1_k127_5430279_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1120.0
HKD1_k127_5430279_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 501.0
HKD1_k127_5430279_10 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000001301 51.0
HKD1_k127_5430279_2 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 365.0
HKD1_k127_5430279_3 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 356.0
HKD1_k127_5430279_4 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000001431 238.0
HKD1_k127_5430279_5 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000004396 210.0
HKD1_k127_5430279_6 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.00000000000000000000000000000000000000000000000002563 185.0
HKD1_k127_5430279_7 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000002658 163.0
HKD1_k127_5430279_8 4Fe-4S binding domain - - - 0.000000000000000000000000001536 113.0
HKD1_k127_5430279_9 4Fe-4S dicluster domain - - - 0.00000000000003972 74.0
HKD1_k127_5447925_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 379.0
HKD1_k127_5447925_1 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 316.0
HKD1_k127_5447925_2 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006112 245.0
HKD1_k127_5447925_3 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503,K19710,K21220 - 2.5.1.3,2.7.7.53 0.0000000000000000000002097 102.0
HKD1_k127_5447925_4 Iron-sulphur cluster biosynthesis K15724 - - 0.00000000008379 67.0
HKD1_k127_5467687_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006348 418.0
HKD1_k127_5467687_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 350.0
HKD1_k127_5467687_10 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000000007621 152.0
HKD1_k127_5467687_11 Pfam:DUF552 K09152 - - 0.000000000000000000005536 96.0
HKD1_k127_5467687_12 Putative zinc- or iron-chelating domain K06940 - - 0.00000003471 63.0
HKD1_k127_5467687_2 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 328.0
HKD1_k127_5467687_3 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 308.0
HKD1_k127_5467687_4 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 300.0
HKD1_k127_5467687_5 Belongs to the UPF0285 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002251 278.0
HKD1_k127_5467687_6 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000003788 215.0
HKD1_k127_5467687_7 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000002692 190.0
HKD1_k127_5467687_8 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000004132 187.0
HKD1_k127_5467687_9 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000002164 162.0
HKD1_k127_5470758_0 PFAM Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 327.0
HKD1_k127_5470758_1 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001878 279.0
HKD1_k127_5470758_2 glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000002201 192.0
HKD1_k127_5495738_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1075.0
HKD1_k127_5495738_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.234e-223 697.0
HKD1_k127_5495738_2 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000007294 181.0
HKD1_k127_5495738_3 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000005025 81.0
HKD1_k127_5495738_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000003484 67.0
HKD1_k127_5503679_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008976 292.0
HKD1_k127_5503679_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000006103 57.0
HKD1_k127_5527737_0 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002271 229.0
HKD1_k127_5527737_1 Transglutaminase-like superfamily - - - 0.0000000000000000000000009852 112.0
HKD1_k127_5530160_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 329.0
HKD1_k127_5530160_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000002113 222.0
HKD1_k127_5531767_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1200.0
HKD1_k127_5531767_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 7.466e-214 685.0
HKD1_k127_5531767_10 Transposase and inactivated derivatives K07494 - - 0.000000000000002244 79.0
HKD1_k127_5531767_11 Transglutaminase-like superfamily - - - 0.0000000001116 74.0
HKD1_k127_5531767_12 - - - - 0.00000004946 55.0
HKD1_k127_5531767_13 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.00001225 51.0
HKD1_k127_5531767_2 Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 469.0
HKD1_k127_5531767_3 Clp protease K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 415.0
HKD1_k127_5531767_4 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 323.0
HKD1_k127_5531767_5 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001011 249.0
HKD1_k127_5531767_6 Belongs to the UPF0200 family - - - 0.0000000000000000000000000000000000002378 147.0
HKD1_k127_5531767_7 - - - - 0.000000000000000000000000000000000005447 142.0
HKD1_k127_5531767_8 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000000006038 147.0
HKD1_k127_5531767_9 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000002436 134.0
HKD1_k127_5538780_0 Formate dehydrogenase alpha subunit K00123,K05299,K22341 - 1.17.1.10,1.17.1.11,1.17.1.9 1.042e-243 769.0
HKD1_k127_5538780_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000008439 174.0
HKD1_k127_5539227_0 - - - - 0.00000000000000000001973 91.0
HKD1_k127_5542481_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 9.058e-199 629.0
HKD1_k127_5542481_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 610.0
HKD1_k127_5542481_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008294 419.0
HKD1_k127_5542481_3 PFAM amino acid-binding ACT domain protein - - - 0.000000000000000648 78.0
HKD1_k127_5564425_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008438 511.0
HKD1_k127_5564425_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000001655 224.0
HKD1_k127_5564425_2 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.00000000000000000000000000000000000000000000000000001093 192.0
HKD1_k127_5564425_3 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.000000000000000000000000000000000000000001532 169.0
HKD1_k127_5564425_4 transposition, DNA-mediated - - - 0.0000000000000000000000000000000000002261 145.0
HKD1_k127_5564425_5 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.00000000000000000000000000002593 125.0
HKD1_k127_5564425_6 CHASE - - - 0.00000000000000000000000001879 113.0
HKD1_k127_5564425_7 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. K19519 - - 0.0000000000000000001155 101.0
HKD1_k127_5564425_8 PFAM CBS domain containing protein - - - 0.000000000000001567 79.0
HKD1_k127_5564425_9 Antibiotic biosynthesis monooxygenase - - - 0.000000002365 61.0
HKD1_k127_5583787_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 5.32e-229 715.0
HKD1_k127_5583787_1 PFAM Cys Met metabolism K01740 - 2.5.1.49 3.724e-215 674.0
HKD1_k127_5583787_2 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 374.0
HKD1_k127_5583787_3 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001002 281.0
HKD1_k127_5589897_0 - - - - 7.042e-229 726.0
HKD1_k127_5589897_1 PFAM ribonuclease II K01147 - 3.1.13.1 8.924e-199 631.0
HKD1_k127_5589897_2 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 533.0
HKD1_k127_5589897_3 Pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000001528 261.0
HKD1_k127_5589897_4 transcription activator, effector binding - - - 0.0000000000000000000000000000000000000005817 169.0
HKD1_k127_5589897_5 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00383 - 1.8.1.7 0.00000000318 58.0
HKD1_k127_5589897_6 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00002397 49.0
HKD1_k127_5589897_7 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382,K00383 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4,1.8.1.7 0.00003922 47.0
HKD1_k127_5605488_0 PFAM ABC transporter K00400 - - 2.541e-214 677.0
HKD1_k127_5605488_1 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000003137 138.0
HKD1_k127_5613862_0 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 538.0
HKD1_k127_5613862_1 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004386 523.0
HKD1_k127_5613862_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 297.0
HKD1_k127_5613862_3 Involved in protein export K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001917 274.0
HKD1_k127_5613862_4 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000008478 238.0
HKD1_k127_5613862_5 Dehydrogenase K00083 - 1.1.1.195 0.000000000000000000000000003042 115.0
HKD1_k127_5613862_6 alcohol dehydrogenase K13979 - - 0.00000000000000000321 90.0
HKD1_k127_5613862_7 Dehydrogenase K12957,K13979 - - 0.000000000000000003467 88.0
HKD1_k127_5613862_8 D-isomer specific 2-hydroxyacid dehydrogenase family protein of Proteobacteria UniRef RepID Q4KE06_PSEF5 K13979 - - 0.000000003034 64.0
HKD1_k127_563071_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 314.0
HKD1_k127_563071_1 TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000007614 195.0
HKD1_k127_563071_2 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000002675 170.0
HKD1_k127_563071_3 COG1404 Subtilisin-like serine proteases K09607 - - 0.00000000000000000004006 94.0
HKD1_k127_563071_4 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000006896 78.0
HKD1_k127_5667238_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 4.303e-194 619.0
HKD1_k127_5667238_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11527 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 440.0
HKD1_k127_5667238_2 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 367.0
HKD1_k127_5667238_3 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 332.0
HKD1_k127_5688968_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 2.553e-215 677.0
HKD1_k127_5688968_1 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000555 168.0
HKD1_k127_5724045_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000309 234.0
HKD1_k127_5724045_1 PFAM ribonuclease H K03469 - 3.1.26.4 0.00000000000000000001181 95.0
HKD1_k127_5787836_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005219 454.0
HKD1_k127_5787836_1 TPR Domain containing protein - - - 0.0000000000000000000002264 102.0
HKD1_k127_5787836_2 Glycogen debranching enzyme - - - 0.000001835 49.0
HKD1_k127_5789571_0 Belongs to the RtcB family K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 415.0
HKD1_k127_5789571_1 Protein of unknown function (DUF541) K09807 - - 0.000000049 57.0
HKD1_k127_5789571_2 - - - - 0.00003916 48.0
HKD1_k127_5795185_0 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 349.0
HKD1_k127_5795185_1 DnaJ molecular chaperone homology domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002152 226.0
HKD1_k127_5795185_10 HDOD domain - - - 0.000004329 51.0
HKD1_k127_5795185_11 - - - - 0.0004734 47.0
HKD1_k127_5795185_2 Signal transduction response regulator, receiver domain - - - 0.00000000000000000000000000000000001841 141.0
HKD1_k127_5795185_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000001351 124.0
HKD1_k127_5795185_4 viral genome integration into host DNA K04763 - - 0.000000000000000000004666 94.0
HKD1_k127_5795185_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000003405 95.0
HKD1_k127_5795185_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000001049 82.0
HKD1_k127_5795185_7 HDOD domain - - - 0.0000000000000001107 86.0
HKD1_k127_5795185_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000006021 73.0
HKD1_k127_5795185_9 lyase activity - - - 0.0000000003077 72.0
HKD1_k127_5802053_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000006293 230.0
HKD1_k127_5802053_1 Putative TM nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000002514 205.0
HKD1_k127_5802053_2 Ferredoxin K05337 - - 0.0000000000000000000005847 97.0
HKD1_k127_5802053_3 Chagasin family peptidase inhibitor I42 K14475 - - 0.000004526 56.0
HKD1_k127_5802053_4 - - - - 0.00000886 48.0
HKD1_k127_5802053_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0002009 46.0
HKD1_k127_5823499_0 COG0464 ATPases of the AAA class K13525 - - 1.768e-320 995.0
HKD1_k127_5823499_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 546.0
HKD1_k127_5823499_2 PFAM PRC-barrel domain - - - 0.000000000000001327 79.0
HKD1_k127_5830217_0 Transposase domain (DUF772) K07481 - - 0.000000000000000000002762 96.0
HKD1_k127_5830217_1 - - - - 0.00000000000002181 77.0
HKD1_k127_5830217_2 transposase activity K07481 - - 0.0000000000003868 70.0
HKD1_k127_5830217_3 Transposase domain (DUF772) K07481 - - 0.0000005859 51.0
HKD1_k127_5867007_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 3.961e-198 627.0
HKD1_k127_5867007_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 438.0
HKD1_k127_5867007_10 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000005302 106.0
HKD1_k127_5867007_11 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.00000000000000000002005 96.0
HKD1_k127_5867007_12 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000001022 73.0
HKD1_k127_5867007_13 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000007919 71.0
HKD1_k127_5867007_14 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A K02944 - - 0.00005188 48.0
HKD1_k127_5867007_2 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 423.0
HKD1_k127_5867007_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 406.0
HKD1_k127_5867007_4 phosphoserine phosphatase SerB K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 396.0
HKD1_k127_5867007_5 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000000000000000001369 222.0
HKD1_k127_5867007_6 cytidyltransferase-related domain K00952 - 2.7.7.1 0.0000000000000000000000000000000000000000000000000000000001019 207.0
HKD1_k127_5867007_7 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000003313 181.0
HKD1_k127_5867007_8 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.0000000000000000000000000000000000000000000006124 173.0
HKD1_k127_5867007_9 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000005289 111.0
HKD1_k127_5868363_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 546.0
HKD1_k127_5868363_1 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000164 116.0
HKD1_k127_5870298_0 oligoendopeptidase F K08602 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007014 604.0
HKD1_k127_5870298_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000003839 64.0
HKD1_k127_5870706_0 Dimerisation domain - - - 0.0000000000000000000000000000000000000000002284 162.0
HKD1_k127_5870706_1 Rhodanese Homology Domain - - - 0.0000000000000000000000756 103.0
HKD1_k127_5870706_2 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000001573 57.0
HKD1_k127_5874035_0 Glycosyl transferase family 21 - - - 0.000000000000000000000000000006577 123.0
HKD1_k127_5890704_0 NnrU protein K21310 - 2.1.1.334 0.0000000000000000000000000000000000000000000000000004812 191.0
HKD1_k127_5890704_1 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.00000000000000000000009151 99.0
HKD1_k127_5890704_2 general stress protein - - - 0.0003166 44.0
HKD1_k127_5896801_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 1.365e-217 692.0
HKD1_k127_5896801_1 Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation - - - 0.0000000000000003206 80.0
HKD1_k127_5896801_2 Involved in regulation of DNA replication K10725 - - 0.00000000001564 65.0
HKD1_k127_5897339_0 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009049 253.0
HKD1_k127_5918693_0 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 309.0
HKD1_k127_5918693_1 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000007112 133.0
HKD1_k127_5918693_2 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000287 73.0
HKD1_k127_5926181_0 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 419.0
HKD1_k127_5926181_1 Domain of unknown function (DUF4968) K01187 - 3.2.1.20 0.00000000000000000000000000000000000409 142.0
HKD1_k127_5936688_0 Sodium Bile acid symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002709 242.0
HKD1_k127_5936688_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00006513 47.0
HKD1_k127_5937382_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1088.0
HKD1_k127_5937382_1 in RNase L inhibitor, RLI K06174 - - 9.577e-241 756.0
HKD1_k127_5937382_2 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 429.0
HKD1_k127_5937382_3 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003089 250.0
HKD1_k127_5937382_4 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000183 209.0
HKD1_k127_5937382_5 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000005206 207.0
HKD1_k127_5937382_6 PIN domain of ribonuclease K07060 - - 0.0000000000000000000000000001005 120.0
HKD1_k127_5937382_7 RNase L inhibitor, RLI - - - 0.00000000000000000009725 94.0
HKD1_k127_5937382_8 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000002646 71.0
HKD1_k127_5950645_0 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000126 147.0
HKD1_k127_5950645_1 PFAM PUA domain K07398 - - 0.000007628 50.0
HKD1_k127_5950645_2 Transcriptional regulator K07722 - - 0.00007088 48.0
HKD1_k127_5950645_3 Belongs to the bacterial solute-binding protein 3 family K02030 - - 0.0003061 48.0
HKD1_k127_5967242_0 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000005666 149.0
HKD1_k127_5984604_0 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000001004 259.0
HKD1_k127_5984604_1 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000000000008249 183.0
HKD1_k127_5984604_2 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000001399 171.0
HKD1_k127_5984604_3 Prokaryotic homologs of the JAB domain - - - 0.000000000000000000000000000000000000000001312 162.0
HKD1_k127_5984604_4 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000281 149.0
HKD1_k127_5984604_5 Domain of unknown function (DUF4352) - - - 0.000000000001088 72.0
HKD1_k127_5984604_6 metal-dependent phosphoesterases (PHP family) - - - 0.000001623 52.0
HKD1_k127_6001719_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 459.0
HKD1_k127_6001719_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 398.0
HKD1_k127_6001719_10 Imidazole acetol-phosphate transaminase K00817 - 2.6.1.9 0.000000000000000000000000000004136 123.0
HKD1_k127_6001719_11 Belongs to the eukaryotic ribosomal protein eL30 family K02908 - - 0.000000000000000000000000001806 114.0
HKD1_k127_6001719_12 PAS domain - - - 0.0000000000000002168 92.0
HKD1_k127_6001719_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 371.0
HKD1_k127_6001719_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000008475 235.0
HKD1_k127_6001719_4 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000886 220.0
HKD1_k127_6001719_5 transcription termination protein NusA K02600 - - 0.000000000000000000000000000000000000000000000000000005289 192.0
HKD1_k127_6001719_6 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000000000001904 175.0
HKD1_k127_6001719_7 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000000001025 171.0
HKD1_k127_6001719_8 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.000000000000000000000000000000000000006589 151.0
HKD1_k127_6001719_9 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000005817 141.0
HKD1_k127_6095281_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 571.0
HKD1_k127_6095281_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 409.0
HKD1_k127_6095281_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 339.0
HKD1_k127_6095281_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 300.0
HKD1_k127_6095281_4 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002701 267.0
HKD1_k127_6095281_5 Large family of predicted nucleotide-binding domains K07158 - - 0.00000000000000000000000000118 116.0
HKD1_k127_6095281_6 - - - - 0.0000000000000001869 85.0
HKD1_k127_6095281_7 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0008562 43.0
HKD1_k127_6120299_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 301.0
HKD1_k127_615810_0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000000000000000000001869 199.0
HKD1_k127_615810_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000002646 172.0
HKD1_k127_615810_2 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000007367 159.0
HKD1_k127_615810_3 Ion channel - - - 0.00000000001455 70.0
HKD1_k127_615810_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000001526 62.0
HKD1_k127_6161631_0 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 332.0
HKD1_k127_6161631_1 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 313.0
HKD1_k127_6176878_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 499.0
HKD1_k127_6176878_1 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 461.0
HKD1_k127_6176878_10 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000001019 168.0
HKD1_k127_6176878_11 TfuA-like protein - - - 0.00000000000000000000000000000000000000000007615 168.0
HKD1_k127_6176878_12 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000000001431 142.0
HKD1_k127_6176878_13 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000002587 119.0
HKD1_k127_6176878_14 - - - - 0.0000000000001388 76.0
HKD1_k127_6176878_15 COG1977 Molybdopterin converting factor, small subunit K03636 - - 0.0000000001254 65.0
HKD1_k127_6176878_2 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 441.0
HKD1_k127_6176878_3 AIR synthase related protein domain protein K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 437.0
HKD1_k127_6176878_4 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008675 390.0
HKD1_k127_6176878_5 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008455 318.0
HKD1_k127_6176878_6 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000004252 260.0
HKD1_k127_6176878_7 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000194 248.0
HKD1_k127_6176878_8 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003043 246.0
HKD1_k127_6176878_9 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000001914 224.0
HKD1_k127_6243985_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 287.0
HKD1_k127_6243985_1 serine threonine protein kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001403 263.0
HKD1_k127_6243985_2 KH domain protein K06961 - - 0.000000000000000000000000000000000000000000000000000000000000006826 221.0
HKD1_k127_6243985_3 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000008242 153.0
HKD1_k127_6243985_4 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000001928 115.0
HKD1_k127_6244301_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 2.572e-238 747.0
HKD1_k127_6244301_1 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 333.0
HKD1_k127_6244301_2 Putative small multi-drug export protein - - - 0.000000000000000000000000000000000000000000000000001502 188.0
HKD1_k127_6244301_3 Helix-turn-helix domain - - - 0.0000000000000000000000000000001377 128.0
HKD1_k127_6244301_4 protein involved in the oxidation of intracellular sulfur K07236 - - 0.00000000000000000169 88.0
HKD1_k127_6244301_5 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000009159 60.0
HKD1_k127_6248333_0 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 325.0
HKD1_k127_6248333_1 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001002 245.0
HKD1_k127_6248333_2 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.0000000000000000000000000000000000000000000000002686 183.0
HKD1_k127_6255017_0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000006061 233.0
HKD1_k127_6255017_1 - - - - 0.0000000000007607 68.0
HKD1_k127_6255017_2 Pentapeptide repeats (9 copies) - - - 0.000000004046 67.0
HKD1_k127_6276068_0 phosphoserine phosphatase activity K01079,K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 478.0
HKD1_k127_6278239_0 PQQ-like domain K00114 - 1.1.2.8 0.000000000000000000000000000000000001021 157.0
HKD1_k127_6278239_1 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000005405 112.0
HKD1_k127_6303676_0 Domain of unknown function (DUF814) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 499.0
HKD1_k127_6303676_1 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 406.0
HKD1_k127_6303676_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000435 355.0
HKD1_k127_6314381_0 PFAM nuclease (SNase domain protein) - - - 0.00000000006546 70.0
HKD1_k127_6314381_1 Polysaccharide biosynthesis/export protein K01991 - - 0.00000162 55.0
HKD1_k127_6337279_0 E1-E2 ATPase K17686 - 3.6.3.54 1.582e-209 662.0
HKD1_k127_6337279_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 545.0
HKD1_k127_6337279_2 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000000000001259 85.0
HKD1_k127_6377806_0 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 468.0
HKD1_k127_6377806_1 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 439.0
HKD1_k127_6377806_2 Protein of unknown function (DUF1614) - - - 0.00000000000000000000000000000000000000000000000000000000000000000008157 237.0
HKD1_k127_6377806_3 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000005021 165.0
HKD1_k127_6396565_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 439.0
HKD1_k127_6396565_1 Conserved TM helix - - - 0.000000000000004844 76.0
HKD1_k127_6411619_0 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 370.0
HKD1_k127_6411619_1 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.0000000000000000000000000000000000000000000000000004668 191.0
HKD1_k127_6411619_2 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000001226 174.0
HKD1_k127_6411619_3 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000003015 176.0
HKD1_k127_6411619_4 Periplasmic copper-binding protein (NosD) - - - 0.00000005386 62.0
HKD1_k127_6411619_5 RibD C-terminal domain - - - 0.000002641 51.0
HKD1_k127_6417154_0 Pyridine nucleotide-disulphide oxidoreductase K07137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005252 588.0
HKD1_k127_6417154_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007593 329.0
HKD1_k127_6417154_2 - - - - 0.000000000000000000000000000000000000000000000000007846 183.0
HKD1_k127_6417154_3 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000003628 166.0
HKD1_k127_6417154_4 TPR Domain containing protein - - - 0.0000000000000000000000000000000000000000002917 167.0
HKD1_k127_6417154_5 Transcriptional regulator, TrmB - - - 0.00000000000000000000000001214 114.0
HKD1_k127_6417154_6 Protein of unknown function (DUF2551) - - - 0.00000000000000000003841 94.0
HKD1_k127_6426907_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004796 258.0
HKD1_k127_6426907_1 Pas domain - - - 0.000000000000000000000000000000000000000000981 167.0
HKD1_k127_6426907_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000002906 139.0
HKD1_k127_6426907_3 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.0000000000000004051 81.0
HKD1_k127_6426907_4 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.00000000007741 65.0
HKD1_k127_6426907_5 protein-glutamate methylesterase activity K00575,K03412,K03413,K13924 - 2.1.1.80,3.1.1.61,3.5.1.44 0.0000001599 55.0
HKD1_k127_6426907_6 PAS domain - - - 0.0000007406 60.0
HKD1_k127_6426907_7 TIGRFAM PAS sensor protein - - - 0.000002238 51.0
HKD1_k127_6426907_8 DDE superfamily endonuclease - - - 0.000003989 49.0
HKD1_k127_6432977_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 1.393e-268 839.0
HKD1_k127_645955_0 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000000000000000006409 161.0
HKD1_k127_645955_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000001502 132.0
HKD1_k127_645955_2 uncharacterised conserved protein UCP017998 - - - 0.000000000000000000000003305 113.0
HKD1_k127_645955_3 Appr-1'-p processing enzyme - - - 0.0000003622 52.0
HKD1_k127_645955_4 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00005465 50.0
HKD1_k127_6468383_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000052 495.0
HKD1_k127_6468383_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006216 454.0
HKD1_k127_6468383_10 Rubrerythrin - - - 0.000000000000000000000000000000000000000007688 156.0
HKD1_k127_6468383_11 Fe-S-cluster oxidoreductase K06940 - - 0.00000001406 63.0
HKD1_k127_6468383_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 435.0
HKD1_k127_6468383_3 PFAM Linocin_M18 bacteriocin protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008244 323.0
HKD1_k127_6468383_4 PINc domain ribonuclease K09006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 292.0
HKD1_k127_6468383_5 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003811 283.0
HKD1_k127_6468383_6 Domain of unknown function DUF128 K21640 - - 0.0000000000000000000000000000000000000000000000000000000000000000002693 236.0
HKD1_k127_6468383_7 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000000000000000000000000000000000000000000000000000000000003082 224.0
HKD1_k127_6468383_8 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000008904 207.0
HKD1_k127_6468383_9 Necessary for normal cell division and for the maintenance of normal septation - - - 0.00000000000000000000000000000000000000000000000000000001526 203.0
HKD1_k127_6502912_0 Transposase domain (DUF772) K07481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 344.0
HKD1_k127_6508518_0 PFAM Pyridoxal-dependent decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003918 375.0
HKD1_k127_6508518_1 SCO1/SenC - - - 0.000000000000000000000000000000000000000000000000000000000003798 211.0
HKD1_k127_6508518_2 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000005433 123.0
HKD1_k127_6508518_3 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000000000000000000000000004507 119.0
HKD1_k127_6516729_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007444 579.0
HKD1_k127_6516729_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 529.0
HKD1_k127_6516729_2 Protein of unknown function (DUF460) K09150 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 488.0
HKD1_k127_6516729_3 DHH family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003105 275.0
HKD1_k127_6516729_4 Nucleotidyl transferase K00966 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000001131 238.0
HKD1_k127_6516729_5 Peptidase C26 K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000005641 213.0
HKD1_k127_6516729_6 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.000000000000000000000000000000000000000000000152 173.0
HKD1_k127_6516729_7 Belongs to the TrpC family K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000001166 173.0
HKD1_k127_6516729_8 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000003844 78.0
HKD1_k127_6534350_0 Transposase domain (DUF772) K07481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 343.0
HKD1_k127_653641_0 PFAM Fibronectin type III domain - - - 0.00000000000000000000000000000000000007525 159.0
HKD1_k127_653641_1 Chagasin family peptidase inhibitor I42 K14475 - - 0.0000001628 60.0
HKD1_k127_653641_2 RHS Repeat - - - 0.0001542 50.0
HKD1_k127_6552885_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 410.0
HKD1_k127_6552885_1 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002721 279.0
HKD1_k127_6552885_2 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000000643 237.0
HKD1_k127_6552885_3 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000008028 96.0
HKD1_k127_6552885_4 Fumarase C-terminus K01678 - 4.2.1.2 0.000000000000000000006194 94.0
HKD1_k127_6552885_5 Uncharacterised ArCR, COG2043 - - - 0.0000000000007043 73.0
HKD1_k127_6555014_0 PFAM GCN5-related N-acetyltransferase K03824 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008859 263.0
HKD1_k127_6555014_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000002187 108.0
HKD1_k127_6555014_2 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.0000000000000000001864 94.0
HKD1_k127_6555014_3 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000001319 53.0
HKD1_k127_6568179_0 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000001378 173.0
HKD1_k127_6568179_1 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.0008326 44.0
HKD1_k127_6582522_0 PFAM ferredoxin-dependent glutamate synthase - - - 0.000000000000000000000000000000000000000000000000000000000000001698 220.0
HKD1_k127_6582522_1 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000001029 220.0
HKD1_k127_6582522_2 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000001307 141.0
HKD1_k127_6582866_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000002292 237.0
HKD1_k127_6582866_1 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000001129 216.0
HKD1_k127_6582866_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000002428 191.0
HKD1_k127_6582866_3 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000611 186.0
HKD1_k127_6582866_4 Belongs to the 'phage' integrase family - - - 0.00000731 51.0
HKD1_k127_6582866_5 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.00002133 50.0
HKD1_k127_6582866_6 Belongs to the 'phage' integrase family K04763 - - 0.00003042 50.0
HKD1_k127_6599521_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005063 570.0
HKD1_k127_6623604_1 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0000000000000000000000000000000000000000000000000002383 191.0
HKD1_k127_6623604_2 restriction endonuclease K07448 - - 0.0000000000000000000000000000001938 125.0
HKD1_k127_6623604_3 - - - - 0.00000002616 59.0
HKD1_k127_6679202_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 2.932e-199 627.0
HKD1_k127_6685599_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 306.0
HKD1_k127_6685599_1 methyltransferase - - - 0.000000000000000000000000000000001785 133.0
HKD1_k127_6685599_2 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000004616 76.0
HKD1_k127_6685599_3 integrase family K04763 - - 0.0000000005776 61.0
HKD1_k127_6730296_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 3.598e-264 827.0
HKD1_k127_6730296_1 Thiamine pyrophosphate enzyme, C-terminal K00187 - 1.2.7.7 3.458e-202 639.0
HKD1_k127_6730296_2 ferredoxin oxidoreductase K00186 - 1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 510.0
HKD1_k127_6730296_3 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 413.0
HKD1_k127_6730296_4 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 372.0
HKD1_k127_6730296_5 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003092 276.0
HKD1_k127_6730296_6 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000001344 221.0
HKD1_k127_6730296_7 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000001298 182.0
HKD1_k127_6730296_8 stage II sporulation K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000006331 179.0
HKD1_k127_6730296_9 - - - - 0.000000000000003134 85.0
HKD1_k127_6731733_0 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. - - - 0.00000000000000000000000000000000000000000000000000004069 192.0
HKD1_k127_6731733_1 COG2041 Sulfite oxidase and related enzymes - - - 0.0000000000000000000000000000000000000000000002661 180.0
HKD1_k127_6731733_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000003356 49.0
HKD1_k127_6732897_0 integrase family K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 327.0
HKD1_k127_6732897_1 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000001076 212.0
HKD1_k127_6732897_3 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000001001 102.0
HKD1_k127_6732897_4 Predicted membrane protein (DUF2207) - - - 0.00000000000000003174 87.0
HKD1_k127_6854739_0 Protein of unknown function (DUF1328) - - - 0.000002137 51.0
HKD1_k127_6860568_0 PFAM PRC-barrel domain protein - - - 0.00000000007669 70.0
HKD1_k127_6860568_1 Universal stress protein - - - 0.00001275 47.0
HKD1_k127_6884748_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003024 270.0
HKD1_k127_6884748_1 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000003231 134.0
HKD1_k127_6884748_2 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000008207 126.0
HKD1_k127_6884748_3 Belongs to the UPF0146 family K09713 - - 0.0000000000000000003167 92.0
HKD1_k127_6884748_4 Transposase domain (DUF772) K07481 - - 0.000000000000000005493 87.0
HKD1_k127_689093_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008363 526.0
HKD1_k127_689093_1 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 499.0
HKD1_k127_689093_10 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000009209 179.0
HKD1_k127_689093_11 PFAM nuclease (SNase domain protein) - - - 0.000002324 57.0
HKD1_k127_689093_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002921 441.0
HKD1_k127_689093_3 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 428.0
HKD1_k127_689093_4 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 327.0
HKD1_k127_689093_5 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000736 272.0
HKD1_k127_689093_6 Imidazole acetol-phosphate transaminase K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000001909 271.0
HKD1_k127_689093_7 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000007291 226.0
HKD1_k127_689093_8 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.000000000000000000000000000000000000000000000000000000000000004883 218.0
HKD1_k127_689093_9 PFAM AMMECR1 domain protein K09141 - - 0.00000000000000000000000000000000000000000000000000005251 193.0
HKD1_k127_6911256_0 zinc metalloprotease whose natural substrate is K06974 GO:0003674,GO:0003824,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000002805 178.0
HKD1_k127_6920852_0 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003921 286.0
HKD1_k127_6941832_0 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 388.0
HKD1_k127_6941832_1 PFAM Radical SAM superfamily - - - 0.00008761 51.0
HKD1_k127_6950655_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 425.0
HKD1_k127_6950655_1 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 356.0
HKD1_k127_6961604_0 TIGRFAM alpha-glucan - - - 1.776e-275 871.0
HKD1_k127_6961604_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.00007403 48.0
HKD1_k127_6961604_2 Phytol kinase K15892 GO:0000003,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0006066,GO:0006629,GO:0006714,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0007275,GO:0008150,GO:0008152,GO:0009719,GO:0009725,GO:0009737,GO:0009791,GO:0009908,GO:0009987,GO:0010033,GO:0016093,GO:0016301,GO:0016310,GO:0016487,GO:0016740,GO:0016772,GO:0016773,GO:0016999,GO:0017144,GO:0022414,GO:0032501,GO:0032502,GO:0033993,GO:0034308,GO:0042221,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0048367,GO:0048437,GO:0048438,GO:0048440,GO:0048467,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0052668,GO:0052669,GO:0052670,GO:0052671,GO:0052673,GO:0061458,GO:0071704,GO:0090567,GO:0097305,GO:0099402,GO:1901615,GO:1901700 2.7.1.216 0.0001843 52.0
HKD1_k127_699182_0 PFAM Glycosyl transferase, group 1 K12996 GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002015 265.0
HKD1_k127_7064951_0 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 410.0
HKD1_k127_7064951_1 Cobalt transport protein K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 370.0
HKD1_k127_7064951_2 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004899 368.0
HKD1_k127_7064951_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000007725 235.0
HKD1_k127_7064951_4 NYN domain - - - 0.00000000000000000000000000000000000000000000000000065 190.0
HKD1_k127_7064951_5 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000004473 161.0
HKD1_k127_7064951_6 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.0000000000000009478 77.0
HKD1_k127_7064951_7 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008677,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.1.1.169 0.00000006968 57.0
HKD1_k127_7064951_8 nuclease - - - 0.0001312 47.0
HKD1_k127_7078706_0 COG3547 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009155 333.0
HKD1_k127_7078706_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000003081 130.0
HKD1_k127_7081127_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 286.0
HKD1_k127_7081127_1 Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000000000001608 179.0
HKD1_k127_7081127_2 cellular manganese ion homeostasis - - - 0.0000000000000000000000000000000000000000001313 163.0
HKD1_k127_7081127_3 Tetratricopeptide repeat K12600 - - 0.00000000000000000000000000000000000003105 151.0
HKD1_k127_7095860_0 YCII-related domain - - - 0.0000000000000000000000000000000000004834 142.0
HKD1_k127_7095860_1 - K00960 - 2.7.7.6 0.000000000000001359 78.0
HKD1_k127_7095860_2 Bacterial regulatory protein, arsR family - - - 0.000000000000003178 79.0
HKD1_k127_7101130_0 Isocitrate/isopropylmalate dehydrogenase K00030,K00052 - 1.1.1.41,1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 571.0
HKD1_k127_7101130_1 PFAM transferase hexapeptide repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000003767 250.0
HKD1_k127_7148593_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 480.0
HKD1_k127_7152974_0 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000001386 179.0
HKD1_k127_7152974_1 PFAM Cache, type 2 domain protein - - - 0.0000000000000000000000000000000004276 137.0
HKD1_k127_7152974_2 Universal stress protein family - - - 0.000000000000000000000000001198 117.0
HKD1_k127_7152974_3 Sulfate permease K03321 - - 0.000000000000000000000000005615 114.0
HKD1_k127_7152974_4 PFAM Cache, type 2 domain protein - - - 0.000000000000000121 84.0
HKD1_k127_7152974_5 Cupin 2, conserved barrel domain protein - - - 0.0000000000003611 76.0
HKD1_k127_7163947_0 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000006541 184.0
HKD1_k127_7163947_1 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000001048 142.0
HKD1_k127_7163947_2 Transcription termination factor nusG - - - 0.00000000000000000000000000001933 124.0
HKD1_k127_7165408_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 295.0
HKD1_k127_7165408_1 PFAM Cation K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000004179 231.0
HKD1_k127_7212807_0 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000000000000000000000306 209.0
HKD1_k127_7212807_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000000000001985 103.0
HKD1_k127_7248518_0 Uncharacterized lipoprotein K07286 - - 0.000000000000000000000000005509 119.0
HKD1_k127_7248518_1 Psort location Cytoplasmic, score - - - 0.0000000000000001806 87.0
HKD1_k127_7248518_3 Alkylmercury lyase - - - 0.0000000000001032 72.0
HKD1_k127_7290260_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000001536 216.0
HKD1_k127_7290260_1 SMART Elongator protein 3 MiaB NifB K06936 - - 0.0000000000000000000000000000000000000000000000000008071 190.0
HKD1_k127_7290260_2 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000002599 152.0
HKD1_k127_7334597_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 568.0
HKD1_k127_7334597_1 PFAM Radical SAM domain protein K02585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008834 406.0
HKD1_k127_7334597_2 SMART Elongator protein 3 MiaB NifB K22226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 346.0
HKD1_k127_7334597_3 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009971 339.0
HKD1_k127_7334597_4 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 303.0
HKD1_k127_7334597_5 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000001728 208.0
HKD1_k127_7334597_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.0000000000000001782 83.0
HKD1_k127_7350504_0 4-Hydroxyphenylpyruvate dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 417.0
HKD1_k127_7350504_1 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001866 263.0
HKD1_k127_7350504_2 Spore germination protein K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004277 262.0
HKD1_k127_7350504_3 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000004056 139.0
HKD1_k127_7350504_4 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000007712 143.0
HKD1_k127_7350504_5 Protein of unknown function (DUF2769) - - - 0.0000000000000000000000003258 108.0
HKD1_k127_7350504_6 Belongs to the rubredoxin family - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114 - 0.000000000000000007957 85.0
HKD1_k127_7350504_7 LUD domain - - - 0.00000000003018 65.0
HKD1_k127_7382490_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 6.363e-320 996.0
HKD1_k127_7382490_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 391.0
HKD1_k127_7382490_10 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.000000000000000000008799 93.0
HKD1_k127_7382490_11 TIR domain - - - 0.0006215 44.0
HKD1_k127_7382490_2 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 317.0
HKD1_k127_7382490_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 304.0
HKD1_k127_7382490_4 Putative RNA methyltransferase K09142 - - 0.000000000000000000000000000000000000000000000000000000000000000139 230.0
HKD1_k127_7382490_5 Heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000002153 213.0
HKD1_k127_7382490_6 TIR domain - - - 0.0000000000000000000000000000000000000000003121 162.0
HKD1_k127_7382490_7 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000004868 126.0
HKD1_k127_7382490_8 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.0000000000000000000000000001578 117.0
HKD1_k127_7382490_9 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000205 103.0
HKD1_k127_7411197_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1689.0
HKD1_k127_7411197_1 Belongs to the glycosyl hydrolase 32 family K00692 - 2.4.1.10 0.000000000000000000000000000000002415 139.0
HKD1_k127_7452203_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 420.0
HKD1_k127_7452203_1 PFAM glutamate--cysteine ligase, GCS2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 398.0
HKD1_k127_7452203_2 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 286.0
HKD1_k127_7452203_3 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003002 259.0
HKD1_k127_7452203_4 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000003663 163.0
HKD1_k127_7463050_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 600.0
HKD1_k127_7463050_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008376 572.0
HKD1_k127_7463050_10 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 336.0
HKD1_k127_7463050_11 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 334.0
HKD1_k127_7463050_12 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004782 267.0
HKD1_k127_7463050_13 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000006548 166.0
HKD1_k127_7463050_14 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000000001161 162.0
HKD1_k127_7463050_15 Histidine kinase - - - 0.00000000000000000000000000113 116.0
HKD1_k127_7463050_16 cheY-homologous receiver domain - - - 0.0000000000000000000007621 99.0
HKD1_k127_7463050_17 Pentapeptide repeats (9 copies) - - - 0.0000000001233 74.0
HKD1_k127_7463050_18 Glycosyl transferase 4-like - - - 0.000000009374 67.0
HKD1_k127_7463050_19 Calcineurin-like phosphoesterase - - - 0.00007202 54.0
HKD1_k127_7463050_2 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 556.0
HKD1_k127_7463050_3 histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 518.0
HKD1_k127_7463050_4 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 472.0
HKD1_k127_7463050_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005803 452.0
HKD1_k127_7463050_6 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 450.0
HKD1_k127_7463050_7 Beta-eliminating lyase K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007007 442.0
HKD1_k127_7463050_8 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 408.0
HKD1_k127_7463050_9 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005091 379.0
HKD1_k127_7500876_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006928 541.0
HKD1_k127_7500876_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 330.0
HKD1_k127_7500876_2 trans-aconitate 2-methyltransferase activity K00598,K02169 - 2.1.1.144,2.1.1.197 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008891 308.0
HKD1_k127_7500876_3 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000009766 178.0
HKD1_k127_7500876_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000006786 162.0
HKD1_k127_7500876_5 Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000002438 112.0
HKD1_k127_7500876_6 Thioredoxin K03671 - - 0.00000000000000000002267 96.0
HKD1_k127_7500876_7 - - - - 0.000000000008379 72.0
HKD1_k127_7500876_8 Beta-Casp domain K07576 - - 0.00001506 49.0
HKD1_k127_7524516_0 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009256 614.0
HKD1_k127_7524516_1 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 332.0
HKD1_k127_7524516_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 316.0
HKD1_k127_7524516_3 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000004458 239.0
HKD1_k127_7524516_4 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000002665 223.0
HKD1_k127_7524516_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000001297 136.0
HKD1_k127_7524516_6 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000005194 96.0
HKD1_k127_7524516_7 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.000001612 50.0
HKD1_k127_7545897_0 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 292.0
HKD1_k127_7545897_1 Putative transposase of IS4/5 family (DUF4096) - - - 0.00000000000000000000000000000000000000000007719 162.0
HKD1_k127_7545897_2 PFAM transposase, IS4 family protein - - - 0.0000000000000000000000000000000000001025 149.0
HKD1_k127_7545897_3 Voltage gated chloride channel - - - 0.000000000000000000000000000000003941 132.0
HKD1_k127_7550613_0 helicase activity - - - 2.249e-220 708.0
HKD1_k127_7550613_1 PFAM Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 349.0
HKD1_k127_7550613_10 PFAM Lon protease (S16) C-terminal proteolytic domain K06870 - - 0.000000000000000000000001287 114.0
HKD1_k127_7550613_12 - - - - 0.00000000000000000000008835 100.0
HKD1_k127_7550613_13 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000009818 94.0
HKD1_k127_7550613_14 PFAM TspO MBR family protein K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.000000000000000006769 85.0
HKD1_k127_7550613_15 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.0000000000000001739 89.0
HKD1_k127_7550613_16 Dodecin K09165 - - 0.000000000000002187 78.0
HKD1_k127_7550613_17 TspO/MBR family K05770 - - 0.000000000000006146 78.0
HKD1_k127_7550613_18 Periplasmic copper-binding protein (NosD) - - - 0.000000000004643 79.0
HKD1_k127_7550613_19 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.000000006902 59.0
HKD1_k127_7550613_2 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005692 282.0
HKD1_k127_7550613_20 PFAM Periplasmic copper-binding protein (NosD) K07218 - - 0.000000008393 68.0
HKD1_k127_7550613_21 Purple acid Phosphatase, N-terminal domain - - - 0.00000000846 68.0
HKD1_k127_7550613_22 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 0.00000006915 55.0
HKD1_k127_7550613_23 Periplasmic copper-binding protein (NosD) K07218 - - 0.0001389 55.0
HKD1_k127_7550613_24 virion core protein (lumpy skin disease virus) - - - 0.0006183 48.0
HKD1_k127_7550613_3 Peptidase S9 prolyl oligopeptidase active site K01281 - 3.4.14.11 0.000000000000000000000000000000000000000000000000000000000000000000000012 254.0
HKD1_k127_7550613_4 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000003022 239.0
HKD1_k127_7550613_5 COG1226 Kef-type K transport systems - - - 0.0000000000000000000000000000000000000000000000000000000000000001124 242.0
HKD1_k127_7550613_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000002339 195.0
HKD1_k127_7550613_7 Large-conductance mechanosensitive channel, MscL K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000000001186 186.0
HKD1_k127_7550613_8 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000001157 162.0
HKD1_k127_7550613_9 Major Facilitator Superfamily - - - 0.000000000000000000000000000000002132 137.0
HKD1_k127_7559821_0 metal-dependent membrane protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 329.0
HKD1_k127_7559821_1 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 331.0
HKD1_k127_7559821_2 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000001822 171.0
HKD1_k127_7559821_3 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000001249 144.0
HKD1_k127_7559821_4 PFAM regulatory protein, ArsR K03892,K21903 - - 0.000000000000000001048 89.0
HKD1_k127_7559821_5 NnrU protein - - - 0.0001765 46.0
HKD1_k127_7559821_6 NnrU protein - - - 0.0003855 43.0
HKD1_k127_758961_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 593.0
HKD1_k127_758961_1 Proton-conducting membrane transporter K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 481.0
HKD1_k127_758961_10 TIGRFAM TIGR00304 family protein - - - 0.0000008539 55.0
HKD1_k127_758961_11 - - - - 0.000007137 53.0
HKD1_k127_758961_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 479.0
HKD1_k127_758961_3 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 419.0
HKD1_k127_758961_4 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 282.0
HKD1_k127_758961_5 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000000001398 220.0
HKD1_k127_758961_6 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.000000000000000000000000000000000000000000000000000000000000008966 223.0
HKD1_k127_758961_7 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000000000000000005095 172.0
HKD1_k127_758961_8 - - - - 0.000000000000000000000000000000000000002499 154.0
HKD1_k127_758961_9 AMP binding K06149,K14064,K14065 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006979,GO:0007154,GO:0008150,GO:0009267,GO:0009314,GO:0009411,GO:0009416,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0010035,GO:0031667,GO:0031668,GO:0031669,GO:0032947,GO:0033554,GO:0034644,GO:0042221,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071496,GO:0104004,GO:1901700 - 0.00000000000000000000000002744 119.0
HKD1_k127_7592955_0 Transposase DDE domain - - - 0.000000000000000000000000000002541 133.0
HKD1_k127_7602922_0 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 290.0
HKD1_k127_7602922_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000006162 240.0
HKD1_k127_7602922_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000006372 158.0
HKD1_k127_7602922_3 PFAM Secreted repeat of - - - 0.0000000000000000000000000000001067 128.0
HKD1_k127_7602922_4 4Fe-4S binding domain - - - 0.0001416 44.0
HKD1_k127_7639023_0 - - - - 0.0000000000000001468 85.0
HKD1_k127_7639023_1 - K00960 - 2.7.7.6 0.0000000000000007169 78.0
HKD1_k127_7639023_2 Transglutaminase-like superfamily - - - 0.000000003747 68.0
HKD1_k127_7639023_3 PKD domain - - - 0.000002069 59.0
HKD1_k127_7651024_0 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005013 261.0
HKD1_k127_7651024_1 extracellular matrix structural constituent - - - 0.000000000000000000000000000000002577 141.0
HKD1_k127_7651024_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K20276 - - 0.0002602 51.0
HKD1_k127_7655446_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.717e-207 654.0
HKD1_k127_7655446_1 DNA topoisomerase II activity K02469 - 5.99.1.3 0.0000000000000000000001714 97.0
HKD1_k127_7689571_0 NnrU protein K21310 - 2.1.1.334 0.00000000000000000000000000001122 124.0
HKD1_k127_7689571_1 SpoIIAA-like - - - 0.000000000001542 72.0
HKD1_k127_7689571_2 Conserved protein - - - 0.000000000001562 70.0
HKD1_k127_7689571_3 NnrU protein K21310 - 2.1.1.334 0.0000000002302 63.0
HKD1_k127_7747371_0 META domain K03668 - - 0.0000000000000000000000000000000000000000008476 168.0
HKD1_k127_7769545_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 496.0
HKD1_k127_7769545_1 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000003667 260.0
HKD1_k127_7769545_2 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. - - - 0.00000000000000000000000000000000000000000000000000006751 201.0
HKD1_k127_7769545_3 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000001865 183.0
HKD1_k127_7769545_4 Uncharacterized protein domain (DUF2202) - - - 0.00000000000000000000000000000000000000007405 165.0
HKD1_k127_7769545_5 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000003366 69.0
HKD1_k127_7796487_0 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 364.0
HKD1_k127_7796487_1 - - - - 0.000000000000000472 83.0
HKD1_k127_7796487_2 Amidohydrolase K07045 - - 0.0000000000006031 71.0
HKD1_k127_7804006_0 PFAM glutamate synthase alpha subunit domain protein K00202 GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281 1.2.7.12 0.0000000008599 68.0
HKD1_k127_7804006_1 oxidoreductase activity - - - 0.000000005958 68.0
HKD1_k127_7804006_2 associated with various cellular activities K03924 - - 0.00001306 57.0
HKD1_k127_7804006_3 proline permease K16261 - - 0.0005437 49.0
HKD1_k127_7806774_0 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 474.0
HKD1_k127_7806774_1 Putative Fe-S cluster - - - 0.0000000000000000000000008835 106.0
HKD1_k127_7806774_2 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000002553 106.0
HKD1_k127_7806774_3 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.00000000000002322 74.0
HKD1_k127_7861105_0 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000001135 105.0
HKD1_k127_7861105_1 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.0000003909 60.0
HKD1_k127_801635_0 lyase activity - - - 0.000000000000000000000000000000000000000002669 165.0
HKD1_k127_820516_0 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000005734 181.0
HKD1_k127_820516_2 Short C-terminal domain - - - 0.00000000000000001709 85.0
HKD1_k127_820516_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000005736 87.0
HKD1_k127_820516_4 membrane protein of uknown function UCP014873 - - - 0.000000000000001227 83.0
HKD1_k127_840646_0 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008659 297.0
HKD1_k127_840646_1 Oxidoreductase NAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000538 233.0
HKD1_k127_840646_2 Universal stress protein family - - - 0.000000000000000000000000000000003781 133.0
HKD1_k127_840646_3 PFAM amidohydrolase - - - 0.00000000000001006 76.0
HKD1_k127_934398_0 Glycogen synthase - - - 6.649e-201 641.0
HKD1_k127_934398_1 DEAD DEAH box helicase domain protein K03725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 466.0
HKD1_k127_934398_2 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 439.0
HKD1_k127_934398_3 Circadian clock protein KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001976 250.0
HKD1_k127_934398_4 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.00000000000000000001133 95.0
HKD1_k127_954206_0 Ion channel K10716 - - 0.00000000000000000000000000000000000000000000000000000000005756 213.0
HKD1_k127_954206_1 radical SAM domain protein - - - 0.00000000000000000000000000000003977 134.0
HKD1_k127_95816_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 496.0
HKD1_k127_95816_1 Starch synthase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 455.0
HKD1_k127_95816_2 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004616 287.0
HKD1_k127_95816_3 Starch synthase catalytic domain - - - 0.00005724 46.0
HKD1_k127_9770_0 - - - - 7.898e-239 747.0
HKD1_k127_9770_1 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 367.0
HKD1_k127_9770_2 COG0500 SAM-dependent methyltransferases K17462 - - 0.00000000000000000000000000000000000000000000000000000000687 207.0
HKD1_k127_9770_3 Flavodoxin domain K03809 - 1.6.5.2 0.0000000000000000000000000000000000000000003803 162.0
HKD1_k127_9770_4 - - - - 0.000000000000000000000000000000000000183 146.0
HKD1_k127_9770_5 Bacterial-like globin K06886 - - 0.000000000000000000000000000000002053 132.0
HKD1_k127_9770_6 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.000158 45.0
HKD1_k127_983515_0 PFAM molydopterin dinucleotide-binding region K00203 - 1.2.7.12 0.00000000000000000000000002656 112.0
HKD1_k127_983515_1 - - - - 0.0000000000000000005736 89.0
HKD1_k127_983515_2 - K01489 - 3.5.4.5 0.000000000000007574 79.0
HKD1_k127_983515_3 DNA polymerase activity K02319 - 2.7.7.7 0.00000000000003289 79.0
HKD1_k127_983515_4 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.0000000003326 62.0
HKD1_k127_983515_5 UPF0391 membrane protein - - - 0.00000003969 56.0
HKD1_k127_983515_6 Phospholipid methyltransferase - - - 0.000001689 53.0
HKD1_k127_983515_7 - - - - 0.0002447 49.0