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Overview

ID MAG01762
Name HKD1_bin.81
Sample SMP0046
Taxonomy
Kingdom Archaea
Phylum Thermoproteota
Class Nitrososphaeria
Order Nitrososphaerales
Family Nitrosopumilaceae
Genus Nitrosotalea
Species
Assembly information
Completeness (%) 51.25
Contamination (%) 0.18
GC content (%) 35.0
N50 (bp) 3,434
Genome size (bp) 873,268

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1103

Gene name Description KEGG GOs EC E-value Score Sequence
HKD1_k127_1070101_0 Enoyl-(Acyl carrier protein) reductase - - - 1.609e-237 748.0
HKD1_k127_1070101_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 508.0
HKD1_k127_1070101_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 331.0
HKD1_k127_1070101_3 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009526 294.0
HKD1_k127_1070101_4 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002975 279.0
HKD1_k127_1070101_5 - - - - 0.000000000000000000000000000000000008634 140.0
HKD1_k127_1070101_6 - - - - 0.00000000000000000000000000008669 121.0
HKD1_k127_1070101_7 - - - - 0.000000000000001446 78.0
HKD1_k127_1073124_0 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 369.0
HKD1_k127_1073124_1 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 336.0
HKD1_k127_1073124_2 FR47-like protein K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000000000001451 177.0
HKD1_k127_1073124_3 HTH DNA binding domain - - - 0.00000000000000000000000003491 108.0
HKD1_k127_1073124_4 FR47-like protein K03789 - 2.3.1.128 0.00000000000000000000009891 98.0
HKD1_k127_1073124_5 Met-10+ like-protein K15429 - 2.1.1.228 0.0000000002353 61.0
HKD1_k127_1135219_0 - - - - 0.0000000000000000000000000000000044 138.0
HKD1_k127_1158165_0 Diphthamide biosynthesis K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 492.0
HKD1_k127_1158165_1 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 402.0
HKD1_k127_1158165_2 COG1522 Transcriptional regulators - - - 0.000000000000000005171 85.0
HKD1_k127_1171462_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 525.0
HKD1_k127_1171462_1 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 425.0
HKD1_k127_1171462_2 Protein of unknown function (DUF354) K09726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 299.0
HKD1_k127_1171462_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000000001512 176.0
HKD1_k127_1174575_0 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 521.0
HKD1_k127_1174575_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 489.0
HKD1_k127_1174575_2 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000606 470.0
HKD1_k127_1174575_3 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007618 444.0
HKD1_k127_1174575_4 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 334.0
HKD1_k127_1174575_5 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000115 276.0
HKD1_k127_1174575_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00001155 48.0
HKD1_k127_1193048_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 578.0
HKD1_k127_1193048_1 Belongs to the peptidase M24B family K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007141 402.0
HKD1_k127_1193048_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 336.0
HKD1_k127_1193048_3 Pfam:DUF137 K09722 - 6.3.2.36 0.00000000000000000000000000000000000000000002287 165.0
HKD1_k127_1206580_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 610.0
HKD1_k127_1206580_1 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 299.0
HKD1_k127_1206580_2 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 295.0
HKD1_k127_1206580_3 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 284.0
HKD1_k127_1206580_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.0000000000000000000000000000000004134 132.0
HKD1_k127_1224587_0 NAD(P)H-binding K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 296.0
HKD1_k127_1224587_1 S-adenosylmethionine synthetase K00789 - 2.5.1.6 0.0000000000000000000000007016 105.0
HKD1_k127_1224587_2 homolog subfamily B member K09507,K09510,K09511 GO:0000122,GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006457,GO:0006950,GO:0006986,GO:0008134,GO:0008150,GO:0008593,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010648,GO:0019219,GO:0019222,GO:0023051,GO:0023057,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031647,GO:0035966,GO:0042221,GO:0042689,GO:0042691,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045595,GO:0045597,GO:0045610,GO:0045612,GO:0045746,GO:0045892,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0050896,GO:0051082,GO:0051087,GO:0051094,GO:0051171,GO:0051172,GO:0051239,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000001245 73.0
HKD1_k127_1224587_3 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000618 51.0
HKD1_k127_1227674_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1289.0
HKD1_k127_1227674_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 526.0
HKD1_k127_1227674_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000156 115.0
HKD1_k127_1239190_0 Peptidase family M3 K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 386.0
HKD1_k127_1239190_1 Deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007583 355.0
HKD1_k127_1307632_0 Kinase binding protein CGI-121 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001955 250.0
HKD1_k127_1307632_1 TatD related DNase K03424 - - 0.00000000000000000000004217 99.0
HKD1_k127_1307632_2 THUMP domain K06963 - - 0.0000000000000000002031 91.0
HKD1_k127_1307632_3 ribosomal protein K02962 - - 0.000000000000000002806 87.0
HKD1_k127_1312480_0 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 522.0
HKD1_k127_1312480_1 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002868 283.0
HKD1_k127_1312480_2 AMMECR1 K09141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004066 254.0
HKD1_k127_1312480_3 Protein of unknown function DUF126 K09128 - - 0.000000000000000000000000000000000000002833 150.0
HKD1_k127_1312480_4 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000000001925 143.0
HKD1_k127_1312480_5 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000009833 120.0
HKD1_k127_1318222_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K18604 - 2.1.3.15,6.4.1.2,6.4.1.3 1.611e-265 822.0
HKD1_k127_1318222_1 Carbamoyl-phosphate synthase L chain K18603 - 6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 322.0
HKD1_k127_1326481_0 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005846 441.0
HKD1_k127_1326481_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001603 236.0
HKD1_k127_1326481_2 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.00000000000000000000000000008355 119.0
HKD1_k127_1326481_3 - - - - 0.000000000008746 65.0
HKD1_k127_1342234_0 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000001312 129.0
HKD1_k127_1342234_1 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.0000000000000000000000001328 116.0
HKD1_k127_1342234_2 - - - - 0.0000000009743 61.0
HKD1_k127_1342234_3 - - - - 0.0000005097 53.0
HKD1_k127_1354513_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 559.0
HKD1_k127_1354513_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 312.0
HKD1_k127_1361408_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 2.924e-280 870.0
HKD1_k127_1361408_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 2.098e-259 805.0
HKD1_k127_1361408_2 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 355.0
HKD1_k127_1361408_3 - - - - 0.0000000000000000003568 92.0
HKD1_k127_1372052_0 Radical SAM K11781 - 2.5.1.77 3.712e-200 630.0
HKD1_k127_1372052_1 Radical SAM K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 533.0
HKD1_k127_1372052_2 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000002259 98.0
HKD1_k127_1387136_0 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 408.0
HKD1_k127_1387136_1 SMC proteins Flexible Hinge Domain K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000775 323.0
HKD1_k127_1398526_0 NAD(P)H-dependent FMN reductase K00299 - 1.5.1.38 0.000000000000000000000000000000000000000000000000000001372 194.0
HKD1_k127_1398526_1 - - - - 0.000000000000000000000000000000003085 131.0
HKD1_k127_1398526_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000000000000000006786 126.0
HKD1_k127_1398526_3 Universal stress protein - - - 0.00000000000000000000000002652 113.0
HKD1_k127_1398526_4 - - - - 0.000000000000888 70.0
HKD1_k127_1398526_5 NAD(P)H-dependent FMN reductase K00299 - 1.5.1.38 0.000004044 51.0
HKD1_k127_1468242_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.999e-216 676.0
HKD1_k127_1468242_1 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit - - - 0.00000000000000000000001367 100.0
HKD1_k127_1468242_2 - - - - 0.000000000442 61.0
HKD1_k127_1490893_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006024 567.0
HKD1_k127_1490893_1 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 355.0
HKD1_k127_1490893_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 315.0
HKD1_k127_1490893_3 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000005539 114.0
HKD1_k127_1495380_0 Glyoxalase-like domain K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000002518 170.0
HKD1_k127_1495380_1 - - - - 0.000000000000000000000000000000000002312 142.0
HKD1_k127_1495380_2 - - - - 0.0000000000000000000000000001594 115.0
HKD1_k127_1495380_3 - - - - 0.00000000000000007252 85.0
HKD1_k127_1557863_0 PFAM aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004341 531.0
HKD1_k127_1557863_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003502 268.0
HKD1_k127_1571541_0 Translation initiation factor K03238 - - 0.00000000000000000000000000000000000000000000000000000000000765 209.0
HKD1_k127_1571541_1 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000003045 154.0
HKD1_k127_1571541_2 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000004636 112.0
HKD1_k127_1571541_3 Serine threonine protein kinase involved in cell cycle control K07178 - 2.7.11.1 0.00000000000000000000003312 104.0
HKD1_k127_1571541_4 - - - - 0.000000000000000003649 84.0
HKD1_k127_1626284_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 1.466e-257 803.0
HKD1_k127_1626284_1 ribosomal protein K02912 - - 0.0000000000000000000000000000000000000000000000000000000529 198.0
HKD1_k127_1626284_2 Belongs to the peptidase S8 family K14647 - - 0.0000000000000000000125 96.0
HKD1_k127_163613_0 Vinylacetyl-CoA Delta-isomerase K14534 - 4.2.1.120,5.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 302.0
HKD1_k127_163613_1 Zinc finger domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005308 273.0
HKD1_k127_163613_2 Signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000001515 242.0
HKD1_k127_163613_3 DEAD DEAH box helicase K05592 - 3.6.4.13 0.000000000000000009392 83.0
HKD1_k127_1646709_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 365.0
HKD1_k127_1646709_1 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 367.0
HKD1_k127_1646709_2 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000000001323 226.0
HKD1_k127_1646709_3 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000000000000006978 218.0
HKD1_k127_1646709_4 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000001088 189.0
HKD1_k127_1646709_5 Binds to the 23S rRNA K02929 - - 0.00000000000000000007219 89.0
HKD1_k127_1646709_6 PFAM ribosomal protein K02978 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000002173 66.0
HKD1_k127_1699197_0 Replication factor C K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 442.0
HKD1_k127_1699197_1 PFAM 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 296.0
HKD1_k127_1699197_2 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000006366 193.0
HKD1_k127_1699197_3 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.0001344 46.0
HKD1_k127_1709464_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 544.0
HKD1_k127_1709464_1 Thioredoxin K03671 - - 0.000000000000000000000000000000000000001205 151.0
HKD1_k127_1709464_2 Archease protein family (MTH1598/TM1083) - - - 0.000000009078 57.0
HKD1_k127_174842_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 503.0
HKD1_k127_174842_1 domain protein K06959 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 326.0
HKD1_k127_1760349_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 316.0
HKD1_k127_1760349_1 ERCC4 domain K10848 - - 0.000000000000000000000000000000000000000000000000000000000004108 210.0
HKD1_k127_1760349_2 PIN domain of ribonuclease K07060 - - 0.0000000000000000000000000000000000000000000001946 172.0
HKD1_k127_178950_0 FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 420.0
HKD1_k127_178950_1 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 312.0
HKD1_k127_178950_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000002542 142.0
HKD1_k127_178950_3 - - - - 0.00000000000000000000000000000001501 130.0
HKD1_k127_182239_0 poly(R)-hydroxyalkanoic acid synthase K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000002326 214.0
HKD1_k127_182239_1 PFAM CBS domain containing protein - - - 0.00001127 55.0
HKD1_k127_1855232_0 antibiotic catabolic process K18235 - - 0.000000000000000000001394 97.0
HKD1_k127_200857_0 tetratricopeptide repeat - - - 0.000000000000000000001685 98.0
HKD1_k127_200857_1 - - - - 0.000000000000000002744 89.0
HKD1_k127_201821_0 Succinyl-CoA ligase like flavodoxin domain K18594 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 441.0
HKD1_k127_203000_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 1.143e-262 817.0
HKD1_k127_203000_1 Histone acetyltransferase K07739 - 2.3.1.48 0.0000000000004978 69.0
HKD1_k127_203000_2 - - - - 0.0000000005304 61.0
HKD1_k127_2225901_0 Thiolase, N-terminal domain K00626 - 2.3.1.9 1.656e-217 678.0
HKD1_k127_2225901_1 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 593.0
HKD1_k127_2225901_2 Carbon-nitrogen hydrolase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 402.0
HKD1_k127_2225901_3 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 305.0
HKD1_k127_2225901_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 313.0
HKD1_k127_2225901_5 - - - - 0.00000000000000000000000000000000000000000000000000002806 192.0
HKD1_k127_2225901_6 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.00000000000000000000000000000000000000002601 156.0
HKD1_k127_2225901_7 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000000000000000000009263 108.0
HKD1_k127_2225901_8 - - - - 0.00000000000000000002931 90.0
HKD1_k127_2229775_0 archaeal flagella assembly protein J K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 369.0
HKD1_k127_2229775_1 transcriptional regulators - - - 0.0000000000000000000000000000000000000000000000000001874 192.0
HKD1_k127_2229775_2 response regulator, receiver K03413 - - 0.00000000000000000000000001857 113.0
HKD1_k127_22524_0 Peptidase family M1 domain K01256,K13722 - 3.4.11.2 2.33e-204 647.0
HKD1_k127_22524_1 SNARE associated Golgi protein K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.0000000000000000000000000000148 123.0
HKD1_k127_2273485_0 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 386.0
HKD1_k127_2273485_1 - K07725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001343 277.0
HKD1_k127_2273485_2 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003449 261.0
HKD1_k127_2273485_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000001333 193.0
HKD1_k127_2273485_4 - - - - 0.00000000000006155 73.0
HKD1_k127_2297512_0 - - - - 0.0000000000000000000000000000000000000000007776 169.0
HKD1_k127_2297512_1 Cytidylyltransferase-like K02201 - 2.7.7.3 0.000000000000000000000000000000000000000309 151.0
HKD1_k127_2305180_0 AsnC-type helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007394 353.0
HKD1_k127_2305180_1 FtsX-like permease family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000948 325.0
HKD1_k127_2325934_0 3-isopropylmalate dehydratase, large subunit K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009901 426.0
HKD1_k127_2325934_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 341.0
HKD1_k127_2325934_2 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 328.0
HKD1_k127_2325934_3 PFAM Nucleotidyl transferase K00966,K03430 - 2.6.1.37,2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001616 283.0
HKD1_k127_2325934_4 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007895 274.0
HKD1_k127_2325934_5 DNA-directed RNA polymerase, alpha subunit 40 kD subunit K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000336 272.0
HKD1_k127_2325934_6 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000001591 257.0
HKD1_k127_2325934_7 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000000006592 224.0
HKD1_k127_2325934_8 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000004582 185.0
HKD1_k127_2325934_9 ribosomal protein K02883 - - 0.0000000000000000000000000000000000000012 150.0
HKD1_k127_2336345_0 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001054 280.0
HKD1_k127_2336345_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009175 276.0
HKD1_k127_2336345_2 COG1960 Acyl-CoA dehydrogenases K00252 - 1.3.8.6 0.000000000000000000000000000000000000000000000000000000002087 203.0
HKD1_k127_2336345_3 COG1960 Acyl-CoA dehydrogenases K00252 - 1.3.8.6 0.0000000000000000000000000000000000005882 141.0
HKD1_k127_2336345_4 - - - - 0.000000000000000000000000000000000002438 139.0
HKD1_k127_2353603_0 Glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 426.0
HKD1_k127_2353603_1 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000001389 175.0
HKD1_k127_2353603_2 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.00000000000000000000000000000005214 126.0
HKD1_k127_2353793_0 TIGRFAM lysine 2,3-aminomutase YodO family protein - - - 1.037e-214 674.0
HKD1_k127_2353793_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000003302 98.0
HKD1_k127_2365731_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 5.038e-233 726.0
HKD1_k127_2365731_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000902 429.0
HKD1_k127_2365731_2 Pterin binding enzyme K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 354.0
HKD1_k127_2365731_3 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 285.0
HKD1_k127_2365731_4 - - - - 0.00000000000000000000000000000000000000002971 159.0
HKD1_k127_2379437_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 1.417e-203 638.0
HKD1_k127_2379437_1 - - - - 0.0000000000000000000000006107 108.0
HKD1_k127_2379437_2 PFAM flavin reductase domain protein, FMN-binding K03574,K18915 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016722,GO:0016723,GO:0032553,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.16.1.10,3.6.1.55 0.000000000002538 68.0
HKD1_k127_2410089_0 Glycosyl transferase family 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007261 554.0
HKD1_k127_2410089_1 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 504.0
HKD1_k127_2410089_2 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 395.0
HKD1_k127_2410089_3 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 351.0
HKD1_k127_2410089_4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 336.0
HKD1_k127_2410089_5 - - - - 0.00000000000000000000000000000000000000003847 158.0
HKD1_k127_2410089_6 - - - - 0.000000000000000000000000000000000000008016 148.0
HKD1_k127_2410089_7 - - - - 0.00000000000000000000906 93.0
HKD1_k127_2455867_0 thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 339.0
HKD1_k127_2455867_1 thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000001519 116.0
HKD1_k127_2481662_0 Sugar-specific transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 494.0
HKD1_k127_2481662_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 337.0
HKD1_k127_2481662_2 conserved protein implicated in secretion - - - 0.000000000000000000000000002898 118.0
HKD1_k127_2481662_3 - - - - 0.00000000000000006056 88.0
HKD1_k127_2481662_4 - - - - 0.000000000000009792 82.0
HKD1_k127_2497272_0 AIPR protein - - - 2.051e-294 912.0
HKD1_k127_2497272_1 transcription factor (CBF NF-Y) - - - 0.000000000000000000000001634 104.0
HKD1_k127_2497272_2 - - - - 0.0000000000000004197 79.0
HKD1_k127_2497272_3 Putative zinc- or iron-chelating domain K06940 - - 0.0000000001803 62.0
HKD1_k127_2558887_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1150.0
HKD1_k127_2558887_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004435 227.0
HKD1_k127_2558887_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000000003545 131.0
HKD1_k127_261682_0 Amidohydrolase family K01464 - 3.5.2.2 2.08e-210 663.0
HKD1_k127_261682_1 Ribose 5-phosphate isomerase K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 286.0
HKD1_k127_2628897_0 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 349.0
HKD1_k127_2628897_1 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002123 278.0
HKD1_k127_2628897_2 DNA methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.000000000000000000000000000000000000000000000000000000001925 206.0
HKD1_k127_2628897_3 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000000000000000004127 144.0
HKD1_k127_2628897_4 GHMP kinases N terminal domain K00891 - 2.7.1.71 0.0000000000000000000004725 98.0
HKD1_k127_2628897_5 - - - - 0.000000126 56.0
HKD1_k127_2792639_0 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 539.0
HKD1_k127_2792639_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006431 300.0
HKD1_k127_2792639_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000006252 221.0
HKD1_k127_2792639_3 - - - - 0.00000000000000000000000000000000000000000000000003216 184.0
HKD1_k127_2792639_4 4 iron, 4 sulfur cluster binding - - - 0.000000000000846 68.0
HKD1_k127_2828944_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 321.0
HKD1_k127_2828944_1 Phosphoribosyl transferase domain K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000005406 202.0
HKD1_k127_2828944_2 DoxX family K15977,K16937 - 1.8.5.2 0.0000000000000000000000000007258 121.0
HKD1_k127_2828944_3 peptidyl-tyrosine sulfation - - - 0.0000000000007321 74.0
HKD1_k127_28395_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 1.615e-247 768.0
HKD1_k127_28395_1 Phosphomethylpyrimidine kinase K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 429.0
HKD1_k127_28395_2 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 393.0
HKD1_k127_28395_3 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000008947 183.0
HKD1_k127_28395_4 Chorismate mutase type II K00812 - 2.6.1.1 0.0000000000000000000000000000000001949 134.0
HKD1_k127_2872230_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000001163 217.0
HKD1_k127_2872230_1 - - - - 0.00000000000000000000000000000000000000006141 156.0
HKD1_k127_2872230_2 PFAM TPR repeat-containing protein - - - 0.000008697 50.0
HKD1_k127_2883011_0 FeS assembly protein SufD K09014,K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 594.0
HKD1_k127_2883011_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008228 269.0
HKD1_k127_2883011_2 of nitrite reductase and ring-hydroxylating K05710 - - 0.000000000000000000000000000000000000001084 149.0
HKD1_k127_2883011_3 FeS assembly protein SufB K09014 - - 0.000000000000002342 75.0
HKD1_k127_2884057_0 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 369.0
HKD1_k127_2884057_1 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.000000000000000000000000000000000000001102 149.0
HKD1_k127_2884057_2 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000009138 127.0
HKD1_k127_2884057_3 Ribosomal L37ae protein family K02921 - - 0.000000000000000000000000003612 111.0
HKD1_k127_2919710_0 FAD dependent oxidoreductase K15736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 559.0
HKD1_k127_2919710_1 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008221 319.0
HKD1_k127_2919710_2 - - - - 0.00000000000000000000001523 103.0
HKD1_k127_2919710_3 small metal-binding protein - - - 0.0000000000000000002499 89.0
HKD1_k127_3007796_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 430.0
HKD1_k127_3007796_1 Ribose-phosphate pyrophosphokinase K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 387.0
HKD1_k127_3007796_2 RNA methylase K07446 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.213 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 288.0
HKD1_k127_3007796_3 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription K12410 - - 0.0000000000000000000000000000000000002175 141.0
HKD1_k127_3051792_0 DNA polymerase K02319 - 2.7.7.7 0.0 1223.0
HKD1_k127_3051792_1 DEAD DEAH box helicase domain protein K03703,K10896 - - 9.058e-230 720.0
HKD1_k127_3051792_2 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 288.0
HKD1_k127_3051792_3 peptidyl-tyrosine sulfation - - - 0.00000000000005524 81.0
HKD1_k127_3068793_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009123 347.0
HKD1_k127_3068793_1 Cytidylyltransferase-like K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000002925 218.0
HKD1_k127_3068793_2 Aminotransferase class-V - - - 0.000000003018 58.0
HKD1_k127_3068793_3 CopC domain K14166 - - 0.000006036 55.0
HKD1_k127_3089879_0 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000004359 185.0
HKD1_k127_3089879_1 - - - - 0.0000000000000000000000000000000000005553 142.0
HKD1_k127_3089879_2 - - - - 0.000000000000000000000000001827 121.0
HKD1_k127_314865_0 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 397.0
HKD1_k127_314865_1 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007625 245.0
HKD1_k127_314865_2 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000004521 109.0
HKD1_k127_314865_4 Phosphate uptake regulator - - - 0.0000004986 51.0
HKD1_k127_3177396_0 membrane-associated protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002453 250.0
HKD1_k127_3177396_1 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000001047 211.0
HKD1_k127_3177396_2 - - - - 0.000000000000000000000000000000000000000002082 158.0
HKD1_k127_3177396_3 Winged helix-turn-helix - - - 0.00000000000000000000000000000000000005301 146.0
HKD1_k127_3177396_4 RNA-binding protein contains TRAM domain - - - 0.0000000000000000000000000000001719 126.0
HKD1_k127_3177396_5 - - - - 0.000000000000000000238 88.0
HKD1_k127_3177396_6 - - - - 0.000000000000002571 87.0
HKD1_k127_3177396_7 - - - - 0.00000000001092 75.0
HKD1_k127_3190008_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 544.0
HKD1_k127_3190008_1 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 312.0
HKD1_k127_3190008_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000004076 149.0
HKD1_k127_3239931_0 Dual specificity phosphatase, catalytic domain K14165 - 3.1.3.16,3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000000007034 255.0
HKD1_k127_3239931_1 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000002156 216.0
HKD1_k127_3239931_2 - - - - 0.00000000000000000000000000000000000002838 146.0
HKD1_k127_3239931_3 PPIC-type PPIASE domain K07533 - 5.2.1.8 0.0000000000000000000000000002122 116.0
HKD1_k127_3239931_4 - - - - 0.0000000000000003054 79.0
HKD1_k127_3285356_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005289 250.0
HKD1_k127_3285356_1 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000002636 128.0
HKD1_k127_3285356_2 Cbs domain - - - 0.000000000005747 72.0
HKD1_k127_3323418_0 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 4.113e-220 692.0
HKD1_k127_3323418_2 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.000000000001876 67.0
HKD1_k127_3395161_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000142 261.0
HKD1_k127_3395161_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000695 224.0
HKD1_k127_3395161_2 Transcriptional regulators - - - 0.000002216 54.0
HKD1_k127_3395161_3 - - - - 0.0006191 46.0
HKD1_k127_3397138_0 transcriptional regulators - - - 0.00000000000000000000000000002159 120.0
HKD1_k127_3397138_1 CBS domain - - - 0.00000000000000000000000002014 119.0
HKD1_k127_3397138_2 Universal stress protein family - - - 0.0000000000007099 77.0
HKD1_k127_3397138_3 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.000000000009657 66.0
HKD1_k127_3405643_0 Amino acid kinase family K00928 - 2.7.2.4 1.457e-209 660.0
HKD1_k127_3405643_1 - - - - 0.00000000003904 65.0
HKD1_k127_3414600_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 296.0
HKD1_k127_3414600_1 - - - - 0.00000000000000000000000000000000000000000000000000000004885 199.0
HKD1_k127_3414600_2 - - - - 0.000000000000000000000000000000000000000000000001799 178.0
HKD1_k127_3414600_3 Pfam:DUF385 - - - 0.00000000000000000000000002848 111.0
HKD1_k127_3414600_4 - - - - 0.000000000000003305 82.0
HKD1_k127_3423535_0 von Willebrand factor (vWF) type A domain - - - 1.4e-216 682.0
HKD1_k127_3423535_1 ATPase family associated with various cellular activities (AAA) K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 287.0
HKD1_k127_3431807_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1480.0
HKD1_k127_3431807_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 8.654e-219 686.0
HKD1_k127_3431807_2 TIGRFAM excinuclease ABC, C subunit K03703 - - 0.00000000000000000000000000000000000000000000000000000000000001093 217.0
HKD1_k127_3458254_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 9.823e-223 695.0
HKD1_k127_3458254_1 ThiF family K21029 - 2.7.7.80 1.228e-207 652.0
HKD1_k127_3458254_2 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000000009378 196.0
HKD1_k127_3458254_3 - - - - 0.000000000000000000007119 98.0
HKD1_k127_3512710_0 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily K08698 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 334.0
HKD1_k127_3512710_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000004758 178.0
HKD1_k127_3512710_2 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000000001041 119.0
HKD1_k127_351883_0 ABC1 family - - - 1.698e-215 679.0
HKD1_k127_351883_1 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004971 284.0
HKD1_k127_351883_2 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000001919 236.0
HKD1_k127_351883_3 - - - - 0.000000000000000000000000000000000000000000000001407 177.0
HKD1_k127_351883_4 PFAM glycoside hydrolase, family 10 K01181 - 3.2.1.8 0.000000000002694 79.0
HKD1_k127_3548518_0 phenylalanyl-tRNA synthetase, beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 602.0
HKD1_k127_3548518_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000006963 139.0
HKD1_k127_3548518_2 - - - - 0.00000000000000000001407 92.0
HKD1_k127_3548518_3 - - - - 0.000000000000000000417 91.0
HKD1_k127_3548518_4 - - - - 0.0000395 46.0
HKD1_k127_3548518_5 - - - - 0.0004725 51.0
HKD1_k127_3651409_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007897 332.0
HKD1_k127_3651409_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 303.0
HKD1_k127_3651409_2 pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.00005762 51.0
HKD1_k127_3669982_0 transcriptional - - - 0.000000000000000000000000000000000000000000000000000004421 196.0
HKD1_k127_3669982_1 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000006056 74.0
HKD1_k127_3707071_0 PFAM type II secretion system K07333 - - 0.000000000000000000003963 102.0
HKD1_k127_3727615_0 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 456.0
HKD1_k127_3727615_1 - - - - 0.0000000000000000000000000000000000000000000000000000000001779 208.0
HKD1_k127_373146_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 6.999e-317 973.0
HKD1_k127_373146_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000000000001405 142.0
HKD1_k127_3743482_0 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 4.514e-208 650.0
HKD1_k127_3743482_1 NADH dehydrogenase K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 301.0
HKD1_k127_3743482_2 NADH ubiquinone oxidoreductase 27 kD subunit K00332 - 1.6.5.3 0.0000000000000000000000000000000002169 132.0
HKD1_k127_3755_0 - - - - 0.00000000000003513 81.0
HKD1_k127_3760846_0 Titin-like K12567 GO:0000070,GO:0000228,GO:0000278,GO:0000280,GO:0000793,GO:0000794,GO:0000819,GO:0001701,GO:0001756,GO:0001932,GO:0002020,GO:0002576,GO:0002791,GO:0002793,GO:0003002,GO:0003007,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003300,GO:0003674,GO:0003779,GO:0003824,GO:0004672,GO:0004674,GO:0004713,GO:0005198,GO:0005200,GO:0005488,GO:0005509,GO:0005515,GO:0005516,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005829,GO:0005856,GO:0005859,GO:0005865,GO:0006323,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006928,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007015,GO:0007049,GO:0007059,GO:0007076,GO:0007154,GO:0007165,GO:0007275,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007507,GO:0007512,GO:0007517,GO:0008015,GO:0008092,GO:0008150,GO:0008152,GO:0008307,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009893,GO:0009952,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010737,GO:0010927,GO:0014706,GO:0014866,GO:0014896,GO:0014897,GO:0015629,GO:0016043,GO:0016192,GO:0016301,GO:0016310,GO:0016459,GO:0016460,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0021591,GO:0022402,GO:0022607,GO:0023052,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030048,GO:0030049,GO:0030154,GO:0030239,GO:0030240,GO:0030241,GO:0030261,GO:0030506,GO:0031032,GO:0031033,GO:0031034,GO:0031323,GO:0031399,GO:0031430,GO:0031433,GO:0031672,GO:0031674,GO:0031974,GO:0031981,GO:0032268,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032991,GO:0033058,GO:0033275,GO:0034622,GO:0035051,GO:0035265,GO:0035282,GO:0035556,GO:0035994,GO:0035995,GO:0036211,GO:0036379,GO:0040007,GO:0040011,GO:0042221,GO:0042325,GO:0042692,GO:0042802,GO:0042805,GO:0043009,GO:0043056,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043292,GO:0043412,GO:0043549,GO:0043621,GO:0043933,GO:0044057,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0044877,GO:0045055,GO:0045214,GO:0045859,GO:0046872,GO:0046903,GO:0048285,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048644,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048739,GO:0048747,GO:0048769,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050982,GO:0051015,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051146,GO:0051171,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051246,GO:0051276,GO:0051338,GO:0051371,GO:0051393,GO:0051592,GO:0051606,GO:0051716,GO:0055001,GO:0055002,GO:0055003,GO:0055006,GO:0055007,GO:0055008,GO:0055013,GO:0060047,GO:0060048,GO:0060255,GO:0060322,GO:0060415,GO:0060419,GO:0060429,GO:0060537,GO:0061053,GO:0061061,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070201,GO:0070252,GO:0070925,GO:0071103,GO:0071688,GO:0071704,GO:0071840,GO:0072359,GO:0080090,GO:0090087,GO:0090257,GO:0097435,GO:0097493,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0140014,GO:0140096,GO:1901077,GO:1901564,GO:1901897,GO:1903047,GO:1903530,GO:1903532,GO:1904951 2.7.11.1 0.0000000000000000375 90.0
HKD1_k127_3780587_0 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 383.0
HKD1_k127_3780587_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000000000000000000000000000000000000000000000002311 202.0
HKD1_k127_3780587_2 - - - - 0.0000168 47.0
HKD1_k127_3825562_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 1.048e-221 698.0
HKD1_k127_3825562_1 ATP-grasp domain K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 534.0
HKD1_k127_3825562_2 - - - - 0.000000000000000000000000000000000000009459 147.0
HKD1_k127_3874288_0 Isocitrate isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 518.0
HKD1_k127_3874288_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 468.0
HKD1_k127_3874288_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 393.0
HKD1_k127_3874288_3 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001557 269.0
HKD1_k127_3874288_4 zinc finger - - - 0.0000000000000000000000008436 106.0
HKD1_k127_3874288_5 Transglutaminase-like superfamily - - - 0.000000000000000000001855 95.0
HKD1_k127_3874288_6 PFAM UspA domain protein - - - 0.000000000000000000003433 98.0
HKD1_k127_3874288_7 - - - - 0.000000000008049 69.0
HKD1_k127_3874288_8 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000003592 59.0
HKD1_k127_3874288_9 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0002445 46.0
HKD1_k127_3888155_0 PLD-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006947 280.0
HKD1_k127_3888155_1 Winged helix-turn-helix - - - 0.00000000000000000000000019 108.0
HKD1_k127_3895230_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 508.0
HKD1_k127_3895230_1 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 417.0
HKD1_k127_3895230_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000002331 117.0
HKD1_k127_3895230_3 - - - - 0.00000000000000000000146 96.0
HKD1_k127_3895230_4 Peptidase C13 family - - - 0.00000000003397 74.0
HKD1_k127_3927491_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 553.0
HKD1_k127_3927491_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 349.0
HKD1_k127_3927491_2 thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000002922 225.0
HKD1_k127_3927491_3 Belongs to the small heat shock protein (HSP20) family - - - 0.000000000000000000002078 95.0
HKD1_k127_3928700_0 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 386.0
HKD1_k127_3928700_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 293.0
HKD1_k127_3928700_2 PFAM SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000348 202.0
HKD1_k127_3928700_3 Mut7-C RNAse domain - - - 0.000000000000000000000000001725 114.0
HKD1_k127_3928700_4 - - - - 0.000000000000007712 75.0
HKD1_k127_3928700_5 zinc finger - - - 0.000000000301 62.0
HKD1_k127_3987701_0 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 308.0
HKD1_k127_3987701_1 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005018 244.0
HKD1_k127_3987701_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000003825 195.0
HKD1_k127_3987701_3 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000009971 157.0
HKD1_k127_3987701_4 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000000008001 89.0
HKD1_k127_3987701_5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000001097 76.0
HKD1_k127_3987701_6 - - - - 0.0003898 47.0
HKD1_k127_3994963_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 488.0
HKD1_k127_3994963_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002495 274.0
HKD1_k127_3994963_2 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000000000000000000000001837 171.0
HKD1_k127_3999652_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000007571 190.0
HKD1_k127_3999652_1 tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000001093 180.0
HKD1_k127_3999652_2 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.00000000000000000000001502 106.0
HKD1_k127_3999652_3 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.0000000000000000000002062 103.0
HKD1_k127_4005402_0 Radical SAM - - - 2.2e-307 946.0
HKD1_k127_4005402_1 - - - - 0.0000000000000000000000000000000000008314 143.0
HKD1_k127_4005402_2 peptidyl-tyrosine sulfation - - - 0.000000000000007323 76.0
HKD1_k127_4005402_3 VIT family - - - 0.00000000602 57.0
HKD1_k127_4032269_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 376.0
HKD1_k127_4032269_1 Histidine kinase K07709 - 2.7.13.3 0.0000000000000000000000000000000000001799 152.0
HKD1_k127_4061877_0 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 381.0
HKD1_k127_4061877_1 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 325.0
HKD1_k127_4061877_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000009567 136.0
HKD1_k127_4072914_0 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 432.0
HKD1_k127_4072914_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000003887 175.0
HKD1_k127_4072914_2 membrane - - - 0.0000004377 55.0
HKD1_k127_4101510_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 477.0
HKD1_k127_4101510_1 pfkB family carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 323.0
HKD1_k127_4101510_2 - - - - 0.00000000000000000000000000000000000000000000000000000005561 200.0
HKD1_k127_4101510_3 dUTPase - - - 0.000000000000000000000000000000000000000000000000003951 183.0
HKD1_k127_4101510_4 Tetrahydromethanopterin S-methyltransferase, subunit A K00577 - 2.1.1.86 0.00000000000000000000000000000000000000000000003277 174.0
HKD1_k127_4113574_0 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000009761 219.0
HKD1_k127_4113574_1 Peptidase A24A, prepilin type IV K02278,K07991 - 3.4.23.43,3.4.23.52 0.00000000007948 67.0
HKD1_k127_4178519_0 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 606.0
HKD1_k127_4178519_1 Lysine biosynthesis K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 436.0
HKD1_k127_4178519_2 Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) K05828 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005845 427.0
HKD1_k127_4178519_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 309.0
HKD1_k127_4230983_0 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009677 445.0
HKD1_k127_4230983_1 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.0000000000000000000000000000000000000000000000000000000000001321 222.0
HKD1_k127_4230983_2 Sodium/hydrogen exchanger family K03316 - - 0.000000000000000000000000000000000000008989 160.0
HKD1_k127_4230983_3 Peptidase family M1 domain K01256,K13722 - 3.4.11.2 0.00000000000000000000000000000000002702 137.0
HKD1_k127_4230983_4 Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome K10389 - - 0.000000000002433 77.0
HKD1_k127_4233783_0 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 486.0
HKD1_k127_4233783_1 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000000000000000000000213 139.0
HKD1_k127_4233783_2 Thioredoxin K03671 - - 0.0000000000000000000000006736 106.0
HKD1_k127_4249839_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000356 253.0
HKD1_k127_4249839_1 - - - - 0.00000000000000000000000000000000000000000000000006165 184.0
HKD1_k127_4249839_2 HIT domain K02503 - - 0.00000000000000000000000000000000000000000000007453 172.0
HKD1_k127_4249839_3 OST3 / OST6 family, transporter family K09584 GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005783,GO:0005788,GO:0006457,GO:0006950,GO:0008150,GO:0008152,GO:0009987,GO:0012505,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016671,GO:0016853,GO:0016860,GO:0016864,GO:0019153,GO:0031974,GO:0033554,GO:0034975,GO:0034976,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070013,GO:0140096 5.3.4.1 0.00000000003097 67.0
HKD1_k127_4298382_0 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 293.0
HKD1_k127_4298382_1 Protein of unknown function DUF99 K09120 - - 0.0000000000000000000000000000000000000000000000000000000005401 205.0
HKD1_k127_4298382_2 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - 0.0000000000000000000000000006551 117.0
HKD1_k127_4303925_0 Nitroreductase K19286 - 1.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 375.0
HKD1_k127_4303925_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 350.0
HKD1_k127_4303925_2 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 299.0
HKD1_k127_4303925_3 YHS domain - - - 0.0000000000000000002587 87.0
HKD1_k127_4303925_4 Pentapeptide repeats (9 copies) - - - 0.0000000000000002413 88.0
HKD1_k127_4303925_5 - - - - 0.0000000001601 67.0
HKD1_k127_4303925_6 Transcriptional regulator K07108 - - 0.0000002238 53.0
HKD1_k127_4325164_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002204 238.0
HKD1_k127_4325164_1 Patch-forming domain C2 of tRNA-guanine transglycosylase K07398 - - 0.00000000000000000000000000000000000000000000000000000000008043 209.0
HKD1_k127_4325164_2 - - - - 0.0000000000000000000000000000000000000000000002095 171.0
HKD1_k127_4325164_3 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000000000000003107 166.0
HKD1_k127_4325164_4 - - - - 0.00000000000000000000806 95.0
HKD1_k127_4372797_0 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004804 369.0
HKD1_k127_4372797_1 KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 317.0
HKD1_k127_4372797_3 Archaeal flagellar protein F K07329 - - 0.0000000000000008957 83.0
HKD1_k127_4395681_0 TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 - 2.6.1.16 9.141e-271 844.0
HKD1_k127_4395681_1 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 412.0
HKD1_k127_4395681_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 301.0
HKD1_k127_4395681_3 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 289.0
HKD1_k127_4395681_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000005104 229.0
HKD1_k127_4395681_5 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000001757 96.0
HKD1_k127_441166_0 response regulator, receiver K03413 - - 0.000000000000000000000006197 108.0
HKD1_k127_441166_1 Fe-S-cluster oxidoreductase K06940 - - 0.00000000000000000000175 94.0
HKD1_k127_441166_2 Lrp/AsnC ligand binding domain - - - 0.000000000000000000002283 95.0
HKD1_k127_441166_3 - - - - 0.0000000000000223 83.0
HKD1_k127_441166_4 sister chromatid segregation - - - 0.00000000001995 74.0
HKD1_k127_441166_5 helix_turn_helix ASNC type K03719 - - 0.0000000009337 66.0
HKD1_k127_4411999_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000008159 267.0
HKD1_k127_4411999_1 membrane K07507 - - 0.0000000000000000000000000000000000000002022 154.0
HKD1_k127_4411999_2 - - - - 0.000000000000000000000006086 103.0
HKD1_k127_4411999_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000001445 99.0
HKD1_k127_4411999_4 Belongs to the universal stress protein A family - - - 0.000000000006376 71.0
HKD1_k127_4411999_5 CBS domain - - - 0.00002939 48.0
HKD1_k127_4417927_0 Pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 507.0
HKD1_k127_4417927_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001316 250.0
HKD1_k127_4421867_0 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 283.0
HKD1_k127_4421867_1 PFAM GvpD gas vesicle - - - 0.0000000000000000000000000000000004209 147.0
HKD1_k127_4421867_2 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000001046 132.0
HKD1_k127_4421867_3 Belongs to the P(II) protein family K02589 - - 0.00002855 51.0
HKD1_k127_454710_0 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 296.0
HKD1_k127_454710_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009125 285.0
HKD1_k127_454710_2 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000006149 201.0
HKD1_k127_454710_3 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000001123 134.0
HKD1_k127_4554176_0 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 451.0
HKD1_k127_4554176_1 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005668 313.0
HKD1_k127_4554176_2 - - - - 0.0000000000000000000000000000000000004239 142.0
HKD1_k127_4557896_0 Zinc-binding dehydrogenase K13979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007168 401.0
HKD1_k127_4557896_1 3-hydroxyacyl-CoA dehydrogenase K15016 - 1.1.1.35,4.2.1.17 0.00000000000000000000000000000000000001424 145.0
HKD1_k127_4557896_2 - - - - 0.0000000000000000000000000007058 114.0
HKD1_k127_4557896_3 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000002603 118.0
HKD1_k127_4563084_0 magnesium chelatase K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 595.0
HKD1_k127_4563084_1 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 460.0
HKD1_k127_4563084_2 - - - - 0.000000000000000002035 88.0
HKD1_k127_4568500_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 490.0
HKD1_k127_4568500_1 ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000001172 218.0
HKD1_k127_4568500_2 - - - - 0.000000000000000000000000000000000001422 140.0
HKD1_k127_4568500_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000001311 83.0
HKD1_k127_4591584_0 Cysteine desulfurase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003941 550.0
HKD1_k127_4591584_1 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 506.0
HKD1_k127_4591584_2 tRNA methyl transferase K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 331.0
HKD1_k127_4591584_3 - - - - 0.000000005087 64.0
HKD1_k127_4619888_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005239 348.0
HKD1_k127_4619888_1 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000116 188.0
HKD1_k127_4619888_2 Binds to the 23S rRNA K02929 - - 0.00000000000000000000000000000000000002122 145.0
HKD1_k127_4619888_3 PFAM ribosomal protein K02978 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000001309 65.0
HKD1_k127_4622618_0 - - - - 0.00000000000001005 82.0
HKD1_k127_4622618_1 Metal-sensitive transcriptional repressor - - - 0.0000000001797 64.0
HKD1_k127_4634920_0 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.0000000000000000000000000000000000000000000000000000001641 197.0
HKD1_k127_4634920_1 ATPase involved in DNA repair - - - 0.000000000000000000000000000000000000000000000000000001602 203.0
HKD1_k127_4634920_2 - - - - 0.000000000000000000000000000000000000005074 148.0
HKD1_k127_4634920_3 - - - - 0.00000000000000000000000000000000000006226 144.0
HKD1_k127_4665092_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000005641 214.0
HKD1_k127_4665092_1 Histidine kinase K03406 - - 0.00000000000000000000000000000000000000000000000002157 196.0
HKD1_k127_4716982_0 Large family of predicted nucleotide-binding domains K06865 - - 0.0000000000000000000000000000000000000000000000000000000000000000004014 234.0
HKD1_k127_4716982_1 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000247 135.0
HKD1_k127_4716982_2 - - - - 0.000000000000000000004145 104.0
HKD1_k127_4780916_0 MGS-like domain K01955 - 6.3.5.5 2.314e-311 962.0
HKD1_k127_4780916_1 carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 451.0
HKD1_k127_4780916_2 MGS-like domain K01955 - 6.3.5.5 0.000003899 48.0
HKD1_k127_4785959_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 509.0
HKD1_k127_4785959_1 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 489.0
HKD1_k127_4785959_2 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004243 278.0
HKD1_k127_4785959_3 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003164 242.0
HKD1_k127_4785959_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000006889 83.0
HKD1_k127_4820568_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006226 499.0
HKD1_k127_4820568_1 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 347.0
HKD1_k127_4820568_2 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 325.0
HKD1_k127_4829352_0 Belongs to the MCM family K10726 - - 1.93e-198 625.0
HKD1_k127_4829352_1 GINS complex protein K09723 - - 0.00000000000000000000000000000000000000000000000006242 182.0
HKD1_k127_4839793_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 362.0
HKD1_k127_4839793_1 - - - - 0.00000000000000000000000000000000000000000000000000000000002956 212.0
HKD1_k127_4839793_2 ATP synthase subunit C K02124 - - 0.00000000000000000000000000531 113.0
HKD1_k127_4839793_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000002925 105.0
HKD1_k127_4839793_4 - - - - 0.00000000000000000000004257 102.0
HKD1_k127_4839793_5 - - - - 0.000000000000003943 83.0
HKD1_k127_4839793_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000002955 71.0
HKD1_k127_4892342_0 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005261 251.0
HKD1_k127_4892342_1 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000001666 235.0
HKD1_k127_4892342_2 Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000001032 137.0
HKD1_k127_4892342_3 PFAM phosphoesterase, PA-phosphatase related K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.000000000000000001419 88.0
HKD1_k127_4897403_0 GTPase of unknown function C-terminal K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 548.0
HKD1_k127_4897403_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 535.0
HKD1_k127_4897403_2 Mn2 -dependent serine threonine protein kinase K08851 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001265 258.0
HKD1_k127_4897403_3 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.00000000000000000000000000000000000000000000000001068 182.0
HKD1_k127_4897403_4 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.000000000000000000000000000000000000000000000006132 177.0
HKD1_k127_4897403_5 - - - - 0.000000000000000000000000000000114 127.0
HKD1_k127_4897403_6 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000002021 93.0
HKD1_k127_4913237_0 NOSIC (NUC001) domain K14564 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 510.0
HKD1_k127_4913237_1 Catalyzes the conversion of dihydroorotate to orotate K00226,K00254,K17723,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 466.0
HKD1_k127_4913237_2 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007105 381.0
HKD1_k127_4913237_3 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 319.0
HKD1_k127_4913237_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005217 269.0
HKD1_k127_4913237_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000000000000000000000001678 264.0
HKD1_k127_4913237_6 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000001571 213.0
HKD1_k127_4962388_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 1.718e-196 620.0
HKD1_k127_4962388_1 - - - - 0.00000006963 55.0
HKD1_k127_4969370_0 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 449.0
HKD1_k127_4969370_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 349.0
HKD1_k127_4969370_2 amine dehydrogenase activity - - - 0.00000000000000000000000000000373 128.0
HKD1_k127_4984512_0 Fibronectin type III domain protein K12567 - 2.7.11.1 0.00000000000000038 92.0
HKD1_k127_4984512_1 - - - - 0.0000000000000004033 84.0
HKD1_k127_4984512_2 Fungalysin metallopeptidase (M36) - - - 0.000000725 55.0
HKD1_k127_4989420_0 Belongs to the MCM family K10726 - - 2.276e-225 703.0
HKD1_k127_4989420_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0000000000000000000000000000000000004565 141.0
HKD1_k127_5003076_0 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen K11159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000074 540.0
HKD1_k127_5003076_1 competence protein COMEC K02238 - - 0.000000000000000000000000000000000000007047 156.0
HKD1_k127_5003076_2 COG0784 FOG CheY-like receiver K03413 - - 0.00000000000000000000000001799 112.0
HKD1_k127_5003076_3 HxlR-like helix-turn-helix - - - 0.00000001718 57.0
HKD1_k127_5003076_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412,K03413 - 3.1.1.61,3.5.1.44 0.000006696 52.0
HKD1_k127_5048568_0 homocysteine S-methyltransferase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 521.0
HKD1_k127_5048568_1 Methionine synthase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000421 260.0
HKD1_k127_5048568_2 cytochrome-c peroxidase activity - - - 0.00000000000000000000000006561 111.0
HKD1_k127_5055408_0 AhpC/TSA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 565.0
HKD1_k127_5055408_1 tRNA pseudouridine synthase K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009279 492.0
HKD1_k127_5055408_10 copper ion binding - - - 0.0000002155 61.0
HKD1_k127_5055408_2 antibiotic catabolic process K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 422.0
HKD1_k127_5055408_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006496 258.0
HKD1_k127_5055408_4 Ribosomal protein L15E K02877 - - 0.0000000000000000000000000000000000000000000000000000000000000006622 222.0
HKD1_k127_5055408_5 - - - - 0.0000000000000004967 86.0
HKD1_k127_5055408_6 PFAM regulatory protein AsnC Lrp family - - - 0.000000000002569 69.0
HKD1_k127_5055408_7 - - - - 0.000000001638 65.0
HKD1_k127_5055408_9 - - - - 0.00000001089 63.0
HKD1_k127_5107271_0 DEAD/H associated K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 417.0
HKD1_k127_5107271_1 S-adenosylmethionine synthetase K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 348.0
HKD1_k127_5107271_2 RecA RadA K04482,K04483 - - 0.000000000000000000000000000000000000000000000000008827 187.0
HKD1_k127_5107271_3 snRNP Sm proteins K04796 - - 0.0000000000000000000000000000000002731 132.0
HKD1_k127_5133838_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000128 264.0
HKD1_k127_5133838_1 Sua5 YciO YrdC YwlC family K07566 - 2.7.7.87 0.00000000000000000000000000000000000004221 147.0
HKD1_k127_5133838_2 Winged helix-turn-helix - - - 0.000000000000000000000000000000001285 131.0
HKD1_k127_5136103_0 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 381.0
HKD1_k127_5136103_1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000005724 243.0
HKD1_k127_5136103_2 AsnC-type helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000001122 181.0
HKD1_k127_5136103_3 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.000000000000000000000000000000000000006112 149.0
HKD1_k127_5137598_0 Phosphoglycerate kinase K00927 - 2.7.2.3 1.433e-199 627.0
HKD1_k127_5137598_1 - - - - 0.00000000000000000000000000697 113.0
HKD1_k127_5137598_2 SUF system FeS assembly protein K04488 - - 0.00000000000007144 72.0
HKD1_k127_5137598_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000002844 74.0
HKD1_k127_5143451_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 4.927e-242 759.0
HKD1_k127_5143451_1 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 493.0
HKD1_k127_5143451_10 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000004223 112.0
HKD1_k127_5143451_2 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 434.0
HKD1_k127_5143451_3 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 414.0
HKD1_k127_5143451_4 Amino acid kinase family K06981 - 2.7.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005053 341.0
HKD1_k127_5143451_5 RNA methylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 330.0
HKD1_k127_5143451_6 NUDIX domain K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 297.0
HKD1_k127_5143451_7 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 302.0
HKD1_k127_5143451_8 - - - - 0.000000000000000000000000000000000000000002608 158.0
HKD1_k127_5143451_9 Rieske 2Fe-2S K05710 - - 0.000000000000000000000000000000000000000006963 156.0
HKD1_k127_5191623_0 GTPase of unknown function C-terminal K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 286.0
HKD1_k127_5191623_1 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000000009131 206.0
HKD1_k127_5191623_2 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000000002954 164.0
HKD1_k127_5191623_3 - - - - 0.00000000000000000000000004138 111.0
HKD1_k127_5208059_0 Protein of unknown function (DUF1512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 489.0
HKD1_k127_5208059_1 FAD linked - - - 0.0000000000000000000000000000000000000000000000000000000000000000000571 238.0
HKD1_k127_5208059_2 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000001672 206.0
HKD1_k127_5208059_3 metalloendopeptidase activity - - - 0.00000000000001833 75.0
HKD1_k127_5214498_0 Transcriptional regulator K07332 - - 0.000000000000000000000000000000000000000007987 163.0
HKD1_k127_5214498_1 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000002816 105.0
HKD1_k127_5214498_2 - - - - 0.00000000000000001624 87.0
HKD1_k127_5214498_3 - - - - 0.0000000002519 65.0
HKD1_k127_5248656_0 conserved protein implicated in secretion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007562 257.0
HKD1_k127_5248656_1 - - - - 0.0000000000000000000000000000000000006098 146.0
HKD1_k127_5248656_2 Major Facilitator Superfamily - - - 0.00000000000000000000003222 113.0
HKD1_k127_5260610_0 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 478.0
HKD1_k127_5260610_1 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007212 470.0
HKD1_k127_5260610_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000001948 70.0
HKD1_k127_5264400_0 Proteasome endopeptidase complex K03432 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 374.0
HKD1_k127_5264400_1 Putative RNA methyltransferase K09142 - - 0.00000000000000000000000000000000000000000000000000003349 192.0
HKD1_k127_5264400_2 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000000000000000000000001938 179.0
HKD1_k127_5264400_3 Helix-turn-helix domain - - - 0.000000000000000000000006972 104.0
HKD1_k127_5265143_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 552.0
HKD1_k127_5265143_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 308.0
HKD1_k127_5265143_2 antibiotic catabolic process K18235 - - 0.0000000000000000000000000008434 129.0
HKD1_k127_5265143_3 - - - - 0.00000000000000005653 87.0
HKD1_k127_5265143_4 Protein of unknown function (DUF3311) - - - 0.0000003943 54.0
HKD1_k127_5305124_0 aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 424.0
HKD1_k127_5305124_1 Belongs to the universal ribosomal protein uS5 family K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004225 315.0
HKD1_k127_5305124_2 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001031 243.0
HKD1_k127_5305124_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000001809 76.0
HKD1_k127_5325883_0 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 446.0
HKD1_k127_5325883_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 342.0
HKD1_k127_5325883_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 307.0
HKD1_k127_5325883_3 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000002071 176.0
HKD1_k127_5325883_4 - - - - 0.0000000000000000000000000000004314 128.0
HKD1_k127_5338827_0 Methionine synthase K00548 - 2.1.1.13 5.446e-316 977.0
HKD1_k127_5338827_1 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000001798 194.0
HKD1_k127_5338827_2 Belongs to the eukaryotic ribosomal protein eL39 family K02924 - - 0.00000000000000006889 81.0
HKD1_k127_5372993_0 DHHA1 domain K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 458.0
HKD1_k127_5372993_1 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.0000000000000000000000000000000000000000000000000000002588 198.0
HKD1_k127_5372993_2 TIGRFAM 2-methylcitrate synthase citrate synthase II K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000003121 162.0
HKD1_k127_5372993_3 - - - - 0.0000005439 53.0
HKD1_k127_5412372_0 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 526.0
HKD1_k127_5412372_1 - - - - 0.000000000000000000000000000000000000000000000000000000001031 212.0
HKD1_k127_5412372_2 Lrp/AsnC ligand binding domain - - - 0.0000000000000003206 80.0
HKD1_k127_5412372_3 Protein of unknown function (DUF541) K09807 - - 0.000009026 49.0
HKD1_k127_5417166_0 Chorismate mutase type II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 537.0
HKD1_k127_5417166_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 532.0
HKD1_k127_5417166_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006646 522.0
HKD1_k127_5471811_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 5.954e-246 770.0
HKD1_k127_5471811_1 Oxidoreductase family, NAD-binding Rossmann fold K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 466.0
HKD1_k127_5471811_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 452.0
HKD1_k127_5471811_3 glycosyl transferase family K01001 - 2.7.8.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 444.0
HKD1_k127_5471811_4 oxidoreductase FAD NAD(P)-binding K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007234 301.0
HKD1_k127_5471811_5 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007469 250.0
HKD1_k127_5471811_6 Nicotinamide-nucleotide adenylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002148 252.0
HKD1_k127_5471811_7 Trm112p-like protein - - - 0.000000000000000000000000000000000000133 143.0
HKD1_k127_5471811_8 - - - - 0.0000000000000000001623 91.0
HKD1_k127_5487192_0 Probable cobalt transporter subunit (CbtA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 302.0
HKD1_k127_5487192_1 Probable cobalt transporter subunit (CbtB) - - - 0.000000000000005861 76.0
HKD1_k127_5487192_2 COG1199 Rad3-related DNA helicases K03722,K10844 - 3.6.4.12 0.0000006042 60.0
HKD1_k127_548811_0 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 516.0
HKD1_k127_548811_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000001753 262.0
HKD1_k127_548811_2 Siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000003133 263.0
HKD1_k127_548811_3 Aldo/keto reductase family - - - 0.00000000000000000000000000000001159 128.0
HKD1_k127_5495215_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 461.0
HKD1_k127_5495215_1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 384.0
HKD1_k127_5495215_2 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 380.0
HKD1_k127_5495215_3 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 374.0
HKD1_k127_5518986_0 Phosphate uptake regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008467 454.0
HKD1_k127_5518986_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 315.0
HKD1_k127_5519613_0 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 435.0
HKD1_k127_5519613_1 Conserved hypothetical ATP binding protein K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 392.0
HKD1_k127_5519613_2 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 364.0
HKD1_k127_5519613_3 Belongs to the enoyl-CoA hydratase isomerase family K15019 - 4.2.1.116 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003356 280.0
HKD1_k127_552907_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 495.0
HKD1_k127_552907_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000504 347.0
HKD1_k127_552907_2 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002516 270.0
HKD1_k127_552907_3 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000000000000000000000000000000000000000000000000000000000000000003973 248.0
HKD1_k127_552907_4 Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity K08096 - 3.5.4.29 0.0000000000000000000000000000000000000000000000000000000000000008865 224.0
HKD1_k127_552907_5 TIGRFAM riboflavin-specific deaminase C-terminal K14654 - 1.1.1.302 0.000000000000000000000000000000000000000000000009528 178.0
HKD1_k127_5530524_0 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 503.0
HKD1_k127_5530524_1 Guanylyl transferase CofC like K14941 - 2.7.7.68 0.0000000000000000000000000000000000000000003425 161.0
HKD1_k127_5530524_2 - - - - 0.0001516 48.0
HKD1_k127_5545391_0 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 385.0
HKD1_k127_5545391_1 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000002351 162.0
HKD1_k127_5545391_2 Binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000006963 156.0
HKD1_k127_5545391_3 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000004186 145.0
HKD1_k127_5545391_4 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.00000000000002891 74.0
HKD1_k127_5547661_0 Cobalamin B12-binding domain protein K16955,K22491 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002416 276.0
HKD1_k127_5547661_1 CBS domain - - - 0.00000000000000000000000000000000000000000003892 167.0
HKD1_k127_5548062_0 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis K07332 - - 6.711e-195 617.0
HKD1_k127_5548062_1 TIGRFAM archaeal flagellin N-terminal-like domain - - - 0.0000000000000000000000000000000000000000000002588 175.0
HKD1_k127_5548062_2 von Willebrand factor, type A K04043,K07114 - - 0.0000000000000000000001364 102.0
HKD1_k127_5559152_0 Chlorophyllase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 343.0
HKD1_k127_5559152_1 copper ion binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000001261 244.0
HKD1_k127_5559152_2 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000007042 164.0
HKD1_k127_5559152_4 - - - - 0.0000000000004822 74.0
HKD1_k127_5559152_5 - - - - 0.0000000000006113 76.0
HKD1_k127_5559152_6 - - - - 0.00000005923 55.0
HKD1_k127_5573530_0 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003859 388.0
HKD1_k127_5573530_1 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 317.0
HKD1_k127_5573530_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412,K03413 - 3.1.1.61,3.5.1.44 0.00000000000000000000000002141 112.0
HKD1_k127_5573530_3 Cyclase dehydrase - - - 0.000000000001334 73.0
HKD1_k127_5577533_0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004748 365.0
HKD1_k127_5577533_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000553 230.0
HKD1_k127_5577533_2 - - - - 0.00000000000000000000000000000000000000000000000000000001202 202.0
HKD1_k127_5623743_0 Glycosyl transferase family group 2 - - - 3.977e-283 883.0
HKD1_k127_5623743_1 Required for chromosome condensation and partitioning - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 388.0
HKD1_k127_5623743_2 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000001337 171.0
HKD1_k127_5627069_0 - - - - 0.0000000000000000000000000000000000001278 146.0
HKD1_k127_5627069_1 - - - - 0.00000000000000000000000000001536 124.0
HKD1_k127_5627069_3 Zinc-dependent metalloprotease - - - 0.000000000000000002143 100.0
HKD1_k127_5643674_0 Belongs to the phosphohexose mutase family K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 577.0
HKD1_k127_5643674_1 Formyl transferase K01433 - 3.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007737 385.0
HKD1_k127_5643674_2 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000000008248 200.0
HKD1_k127_5643674_3 Binds to the 23S rRNA K02896 - - 0.00000000000000000000000000000002273 126.0
HKD1_k127_5643674_4 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.0000000000000000000000001827 106.0
HKD1_k127_5643674_6 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000009729 57.0
HKD1_k127_5643674_8 Nucleoside diphosphate kinase K00940 GO:0000302,GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009636,GO:0009987,GO:0010035,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046677,GO:0046939,GO:0050896,GO:0051716,GO:0055086,GO:0070301,GO:0070887,GO:0071236,GO:0071704,GO:0097237,GO:1901360,GO:1901700,GO:1901701 2.7.4.6 0.00003453 46.0
HKD1_k127_5667324_0 Tyrosine--tRNA ligase K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 495.0
HKD1_k127_5667324_1 PFAM Luciferase-like monooxygenase - - - 0.00001476 52.0
HKD1_k127_56981_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 1.013e-226 710.0
HKD1_k127_56981_1 - - - - 0.00000000000000000000000000000000000000000008672 169.0
HKD1_k127_56981_2 ATPase family associated with various cellular activities (AAA) K04748 - - 0.000000000000000000000000000001717 121.0
HKD1_k127_5739559_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 8.389e-310 959.0
HKD1_k127_5739559_1 - - - - 0.000000000000000000000001083 109.0
HKD1_k127_5739559_2 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000007169 78.0
HKD1_k127_5741923_0 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000001646 195.0
HKD1_k127_5741923_1 - - - - 0.00000000000000000000000000000000000000000000000000008599 188.0
HKD1_k127_5741923_2 Domain of unknown function (DUF4443) - - - 0.00000000000000000000000000000000000003636 148.0
HKD1_k127_5741923_3 lactoylglutathione lyase activity - - - 0.00000000004471 68.0
HKD1_k127_5822784_0 TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006456 542.0
HKD1_k127_5822784_1 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005061 295.0
HKD1_k127_5822784_2 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.000000000000000000000000000000000000000000000000000000000000001268 224.0
HKD1_k127_5822784_3 COG2002 Regulators of stationary sporulation gene expression - - - 0.00000000000000000000000000000000000004442 146.0
HKD1_k127_5822784_4 - - - - 0.000000000000000000000006867 106.0
HKD1_k127_5822784_5 - - - - 0.000000000000000000006397 98.0
HKD1_k127_5822784_6 CBS domain - - - 0.0000639 48.0
HKD1_k127_5849536_0 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000004067 149.0
HKD1_k127_5849536_1 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000001131 147.0
HKD1_k127_5849536_2 Lrp/AsnC ligand binding domain - - - 0.000000000000000739 78.0
HKD1_k127_5849536_3 - K00960 - 2.7.7.6 0.000000000000004616 76.0
HKD1_k127_5849536_4 signal transduction histidine kinase - - - 0.0008026 49.0
HKD1_k127_5868819_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008992 452.0
HKD1_k127_5868819_1 Chlorite dismutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009475 332.0
HKD1_k127_5868819_2 Domain of unknown function (DUF1802) - - - 0.00000000000000000000000000000000000000000000000000000000000000004058 227.0
HKD1_k127_5868819_3 - - - - 0.00000000000000000000000000000000000000000000133 171.0
HKD1_k127_5868819_4 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.0000000000000000000005942 98.0
HKD1_k127_5868819_5 - - - - 0.000000001739 63.0
HKD1_k127_5868819_6 - - - - 0.0009819 49.0
HKD1_k127_5869787_0 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 350.0
HKD1_k127_5869787_1 - - - - 0.00000000000000002793 85.0
HKD1_k127_5873977_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006053 481.0
HKD1_k127_5873977_1 Winged helix-turn-helix - - - 0.0000000000000000000000000000000000000008566 149.0
HKD1_k127_5949490_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.019e-210 666.0
HKD1_k127_5949490_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 490.0
HKD1_k127_5949490_2 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 285.0
HKD1_k127_6036257_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000002165 214.0
HKD1_k127_6036257_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K02548,K17105,K20616 - 2.5.1.42,2.5.1.74 0.000000000000000000000000000789 124.0
HKD1_k127_6036257_2 COG0784 FOG CheY-like receiver K03413 - - 0.00000000000000000000000003488 112.0
HKD1_k127_6036257_3 - - - - 0.00001926 51.0
HKD1_k127_6206178_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 295.0
HKD1_k127_6261137_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 461.0
HKD1_k127_6261137_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 360.0
HKD1_k127_6261137_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K01817 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20,5.3.1.24 0.000000000000000000000000000000000000000000000007397 174.0
HKD1_k127_6290287_0 - - - - 0.000000000000000000000000000000000000004466 153.0
HKD1_k127_6290287_1 - - - - 0.00000000000000000000000000000000000005101 145.0
HKD1_k127_6290287_2 Uncharacterized conserved protein (DUF2196) - - - 0.00000000000000000000004654 99.0
HKD1_k127_6299121_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 497.0
HKD1_k127_6299121_1 PAC2 family K06869 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000195 260.0
HKD1_k127_6299121_2 cysteinyl-tRNA synthetase K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000673 225.0
HKD1_k127_6299121_3 Alba K03622 - - 0.000000000000000000000000001968 113.0
HKD1_k127_6299121_4 COG1522 Transcriptional regulators - - - 0.0000000000000000000005576 97.0
HKD1_k127_6299121_5 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000003557 92.0
HKD1_k127_6299121_6 - - - - 0.000000000000000001951 87.0
HKD1_k127_6299121_7 - - - - 0.000108 48.0
HKD1_k127_6299121_8 Acetyltransferase (GNAT) family - - - 0.0002311 48.0
HKD1_k127_6327274_0 Histone acetyltransferase K07739 - 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 521.0
HKD1_k127_6327274_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 494.0
HKD1_k127_6327274_2 COG0530 Ca2 Na antiporter K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 302.0
HKD1_k127_6327274_3 - - - - 0.0000000000000000000000000000000000000000000000000005863 185.0
HKD1_k127_6327274_4 COG1522 Transcriptional regulators - - - 0.000000000000000000003466 96.0
HKD1_k127_6332794_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 301.0
HKD1_k127_6332794_1 - - - - 0.000000000000000000000006082 101.0
HKD1_k127_6332794_2 - - - - 0.00000000002643 64.0
HKD1_k127_6339451_0 DEAD DEAH box helicase K06877 - - 0.0 1118.0
HKD1_k127_6339451_1 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 347.0
HKD1_k127_6339629_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000904 252.0
HKD1_k127_6339629_1 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000001045 179.0
HKD1_k127_6339629_2 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000000000000000000005114 161.0
HKD1_k127_6339629_3 RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000000000000000001543 154.0
HKD1_k127_6339629_4 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000001509 107.0
HKD1_k127_6339629_5 Methyltransferase K02493 - 2.1.1.297 0.00000000001837 71.0
HKD1_k127_6343567_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000006801 238.0
HKD1_k127_6383498_0 RNase L inhibitor, RLI K06174 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001191 264.0
HKD1_k127_6383498_1 RNase L inhibitor, RLI K06174 - - 0.00000000000000000000000000000000000000000000000000002609 189.0
HKD1_k127_6383498_3 - - - - 0.00000000001004 67.0
HKD1_k127_6394770_0 FAD linked - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001409 250.0
HKD1_k127_6394770_1 Putative tRNA binding domain K06878 - - 0.00000000000000000000000000000000000000000003114 163.0
HKD1_k127_6394770_2 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000004551 150.0
HKD1_k127_6394770_3 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.000002438 49.0
HKD1_k127_6434895_0 PFAM Iron-containing alcohol dehydrogenase K18602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 512.0
HKD1_k127_6434895_1 Luciferase-like monooxygenase K14728 - - 0.0000000000000000000000000000000000000000000000000000000000004333 212.0
HKD1_k127_6434895_2 - - - - 0.00000000000000000000000000000000000000000000000000001814 196.0
HKD1_k127_6434895_3 MOFRL family K11529 - 2.7.1.165 0.000000001268 64.0
HKD1_k127_6536434_0 COG1252 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009821 341.0
HKD1_k127_6536434_1 - - - - 0.00000000889 58.0
HKD1_k127_6536624_0 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 600.0
HKD1_k127_6536624_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 380.0
HKD1_k127_6536624_2 Iron-sulfur cluster assembly protein - - - 0.0000000000000000000000000000000000000000000000546 170.0
HKD1_k127_6537315_0 Cysteine synthase K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 487.0
HKD1_k127_6537315_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004731 464.0
HKD1_k127_6553208_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000095 466.0
HKD1_k127_6553208_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 343.0
HKD1_k127_6553208_2 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 322.0
HKD1_k127_6553208_3 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000008494 244.0
HKD1_k127_6553208_4 Subtilase family - - - 0.00000000000000000000000000000000000003774 152.0
HKD1_k127_6564116_0 cytochrome c biogenesis protein K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006849 313.0
HKD1_k127_6564116_1 AhpC/TSA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 306.0
HKD1_k127_6564116_2 8-amino-7-oxononanoate synthase K00639 - 2.3.1.29 0.00000000000000000000000000000000005321 136.0
HKD1_k127_656629_0 methyl-accepting chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 362.0
HKD1_k127_656629_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001097 268.0
HKD1_k127_656629_2 Chemotaxis signal transduction protein K03408 - - 0.0000000000000000000000000001274 119.0
HKD1_k127_6580468_0 Cytochrome b subunit of the bc complex K00412 - - 9.673e-240 747.0
HKD1_k127_6580468_1 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 376.0
HKD1_k127_6580468_2 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.00000000000000000000000000000000000000006413 154.0
HKD1_k127_6580468_3 COG0723 Rieske Fe-S protein K15878 - - 0.000001789 57.0
HKD1_k127_6604366_0 aspartate-semialdehyde dehydrogenase K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 549.0
HKD1_k127_6604366_1 UbiD family decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 520.0
HKD1_k127_6604366_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 458.0
HKD1_k127_6604366_3 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000001158 225.0
HKD1_k127_6604366_4 Lrp/AsnC ligand binding domain K03718 - - 0.00000000000000000000000000000000000000000000000000000000000001286 218.0
HKD1_k127_662083_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 578.0
HKD1_k127_662083_1 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 377.0
HKD1_k127_662083_2 8-amino-7-oxononanoate synthase K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 311.0
HKD1_k127_6624948_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 473.0
HKD1_k127_6624948_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 308.0
HKD1_k127_6624948_2 Multicopper oxidase K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000156 235.0
HKD1_k127_6624948_3 Cytochrome oxidase assembly protein K02259 - - 0.000000000000000000000000000000000000000000000000000000002178 203.0
HKD1_k127_6624948_4 - - - - 0.0000000000000000009166 86.0
HKD1_k127_6624948_5 - - - - 0.000000000000000002348 93.0
HKD1_k127_6624948_6 zinc finger - - - 0.000000000000001287 77.0
HKD1_k127_6659877_0 Uncharacterised protein family (UPF0182) K09118 - - 0.0 1286.0
HKD1_k127_6659877_1 glutamine amidotransferase K01951 - 6.3.5.2 0.0000000000000000000000000000000004998 135.0
HKD1_k127_6659877_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000005428 123.0
HKD1_k127_6659877_3 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000000000000009309 74.0
HKD1_k127_6659877_4 glutamine amidotransferase K01951 - 6.3.5.2 0.00001077 47.0
HKD1_k127_6668418_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 322.0
HKD1_k127_6668418_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003246 253.0
HKD1_k127_6668418_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000000000003703 227.0
HKD1_k127_6668418_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000001813 184.0
HKD1_k127_6668418_4 Located at the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000002923 153.0
HKD1_k127_6668418_5 - - - - 0.000000000000000000000000000000000002862 139.0
HKD1_k127_6668418_6 ribosomal protein S14 K02954 - - 0.000000000000000000000002017 102.0
HKD1_k127_6668418_7 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000003585 75.0
HKD1_k127_6694534_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 503.0
HKD1_k127_6694534_1 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000043 259.0
HKD1_k127_6694534_2 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000184 250.0
HKD1_k127_6694534_3 Belongs to the archaeal adenylate kinase family K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000001303 200.0
HKD1_k127_6725797_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 1.048e-195 622.0
HKD1_k127_6725797_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 464.0
HKD1_k127_674906_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 493.0
HKD1_k127_674906_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 377.0
HKD1_k127_674906_2 Hemerythrin HHE cation binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000004314 235.0
HKD1_k127_674906_3 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.00000000000000000000000000000000001101 140.0
HKD1_k127_682871_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 527.0
HKD1_k127_682871_1 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 349.0
HKD1_k127_682871_2 - K07725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006648 271.0
HKD1_k127_682871_3 conserved protein implicated in secretion - - - 0.000000000000000000000001883 104.0
HKD1_k127_682871_4 - - - - 0.0000000000003476 71.0
HKD1_k127_6928656_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 497.0
HKD1_k127_6928656_1 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 468.0
HKD1_k127_6928656_2 Cobalt chelatase (CbiK) K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 366.0
HKD1_k127_6928656_3 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 293.0
HKD1_k127_6928656_4 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000006268 117.0
HKD1_k127_698881_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 589.0
HKD1_k127_698881_1 F420-0:Gamma-glutamyl ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 308.0
HKD1_k127_698881_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004299 258.0
HKD1_k127_7025421_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 507.0
HKD1_k127_7025421_1 helix_turn_helix ASNC type - - - 0.00000000000000000000000000000000000000000003135 164.0
HKD1_k127_7095079_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 524.0
HKD1_k127_7095079_1 Radical SAM domain protein K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007372 513.0
HKD1_k127_7095079_2 transporter - - - 0.0000000000000000000000000002957 117.0
HKD1_k127_7095079_4 - - - - 0.00000001887 58.0
HKD1_k127_7098458_0 Belongs to the SUI1 family K03113 - - 0.00000000000000000000000000000000000000000000001373 171.0
HKD1_k127_7098458_1 Predicted membrane protein (DUF2070) K08979 - - 0.000000000000000000000000000000000000000000000431 174.0
HKD1_k127_7098458_2 CAAX protease self-immunity - - - 0.000000000000000000000000007513 113.0
HKD1_k127_7098458_3 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.0000000000000000000000007042 107.0
HKD1_k127_7098458_4 Sec61beta family - - - 0.00000000000000007365 81.0
HKD1_k127_7125968_0 TCP-1/cpn60 chaperonin family K22447 - - 3.285e-282 874.0
HKD1_k127_7125968_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008212 381.0
HKD1_k127_7125968_2 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000000000005505 225.0
HKD1_k127_7127840_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.654e-232 726.0
HKD1_k127_7127840_1 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 406.0
HKD1_k127_7127840_2 phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 346.0
HKD1_k127_7127840_3 - - - - 0.000000000000000000000000000000000059 138.0
HKD1_k127_7127840_4 Cupredoxin-like domain - - - 0.000000000000000000000000000001107 127.0
HKD1_k127_7127840_5 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000327 88.0
HKD1_k127_7143013_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 397.0
HKD1_k127_7143013_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002606 280.0
HKD1_k127_7143013_2 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000000000000000000000000000003721 207.0
HKD1_k127_7219493_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 589.0
HKD1_k127_7219493_1 UbiD family decarboxylase K03182 - 4.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 558.0
HKD1_k127_7219493_2 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 556.0
HKD1_k127_7219493_3 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 412.0
HKD1_k127_7219493_4 - - - - 0.00000000005386 65.0
HKD1_k127_7234769_0 DHHA1 domain K07463 - - 9.799e-204 642.0
HKD1_k127_7234769_1 ribosomal protein K02956 - - 0.0000000000000000000000000000000000000000000000000000000000000001644 224.0
HKD1_k127_7234769_2 - - - - 0.000000000000000000000000000000000004589 139.0
HKD1_k127_7234769_3 - - - - 0.00000000000000002218 85.0
HKD1_k127_7234769_4 - - - - 0.0000000000007842 69.0
HKD1_k127_7243283_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1190.0
HKD1_k127_7243283_1 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 0.0 1079.0
HKD1_k127_7243283_10 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000004015 147.0
HKD1_k127_7243283_11 - - - - 0.0000000000000000000000007732 105.0
HKD1_k127_7243283_2 adenylosuccinate lyase K01756 - 4.3.2.2 1.038e-210 663.0
HKD1_k127_7243283_3 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 410.0
HKD1_k127_7243283_4 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 309.0
HKD1_k127_7243283_5 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002617 284.0
HKD1_k127_7243283_6 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001757 277.0
HKD1_k127_7243283_7 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000001853 247.0
HKD1_k127_7243283_8 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000000000000000000000787 200.0
HKD1_k127_7243283_9 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 0.00000000000000000000000000000000000000000000000000001546 189.0
HKD1_k127_7251324_0 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 423.0
HKD1_k127_7251324_1 - - - - 0.00000000000000000000000000000000000000000000000000000000003633 218.0
HKD1_k127_7251324_2 cytochrome-c peroxidase activity - - - 0.000000000000000000000000000000000000005848 148.0
HKD1_k127_731298_0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 1.672e-211 662.0
HKD1_k127_731298_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000003292 254.0
HKD1_k127_731298_2 Rieske-like [2Fe-2S] domain K05710 - - 0.000000000000000000000000000000000000000000000004566 173.0
HKD1_k127_731298_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000004242 134.0
HKD1_k127_7344910_0 Signal peptidase K13280 - 3.4.21.89 0.0000000000003588 79.0
HKD1_k127_7344910_1 Protein of unknown function (DUF1722) - - - 0.0001268 44.0
HKD1_k127_7344910_2 - - - - 0.0001471 52.0
HKD1_k127_7376757_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01868 - 6.1.1.3 2.522e-297 921.0
HKD1_k127_7376757_1 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 351.0
HKD1_k127_7376757_2 Tetratricopeptide repeat - - - 0.0000000000000000000001779 98.0
HKD1_k127_7378336_0 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 550.0
HKD1_k127_7378336_1 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000002829 185.0
HKD1_k127_7378336_2 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000001035 104.0
HKD1_k127_7380116_0 PFAM Alcohol dehydrogenase GroES-like domain - - - 1.048e-197 619.0
HKD1_k127_7380116_1 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000216 229.0
HKD1_k127_7391640_0 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003057 275.0
HKD1_k127_7391640_1 Fungalysin metallopeptidase (M36) - - - 0.0000000000000005467 86.0
HKD1_k127_7413862_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 303.0
HKD1_k127_7413862_1 inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000001711 221.0
HKD1_k127_7415300_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000001812 226.0
HKD1_k127_7463819_0 conserved protein implicated in secretion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 331.0
HKD1_k127_7463819_1 Asp/Glu/Hydantoin racemase K01776 - 5.1.1.3 0.000000000000000000000000000000000000000004072 158.0
HKD1_k127_7463819_2 - - - - 0.0000000008313 66.0
HKD1_k127_7464308_0 COG1252 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 2.062e-197 623.0
HKD1_k127_7464308_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001748 267.0
HKD1_k127_7464308_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000004393 198.0
HKD1_k127_7464308_3 - - - - 0.000000000000000000000000000000000000007477 147.0
HKD1_k127_7468069_0 Collagen triple helix repeat (20 copies) - - - 0.00000000000000000000001347 104.0
HKD1_k127_7468069_1 Domain of unknown function (DUF333) - - - 0.00000000000001168 76.0
HKD1_k127_7476602_0 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 394.0
HKD1_k127_7476602_1 Transcription elongation factor - - - 0.0000000000000000000000000000000000000000000000000000000001876 209.0
HKD1_k127_7476602_2 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - 0.0000000000000000000000000000000000000000000003952 169.0
HKD1_k127_7539644_0 xylanase chitin deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000008592 130.0
HKD1_k127_7539644_1 Transglutaminase-like superfamily - - - 0.000000000000002305 81.0
HKD1_k127_7539644_2 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis - - - 0.000000000005925 70.0
HKD1_k127_7539644_3 - - - - 0.000000000134 66.0
HKD1_k127_7566012_0 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 337.0
HKD1_k127_7566012_1 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005322 276.0
HKD1_k127_761501_0 chromosome segregation and condensation protein ScpA K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 287.0
HKD1_k127_761501_1 segregation and condensation protein K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005711 264.0
HKD1_k127_761501_2 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000000000000000000000001821 204.0
HKD1_k127_761501_3 response regulator, receiver K03413 - - 0.000000000000000000000000000000000000000000000000000003491 199.0
HKD1_k127_761501_4 - - - - 0.000000000000000000000000000000000000000000001096 172.0
HKD1_k127_761501_5 Ribosomal protein S8e K02995 - - 0.0000000000000000000003301 98.0
HKD1_k127_761501_6 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000891 87.0
HKD1_k127_7618268_0 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 499.0
HKD1_k127_7618268_1 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 378.0
HKD1_k127_7618268_2 Monooxygenase subunit B protein K10945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001877 255.0
HKD1_k127_7618268_3 - - - - 0.000000000000000000000000000003706 123.0
HKD1_k127_7618268_4 kinase activity K01006,K01007,K22424 - 2.7.3.13,2.7.9.1,2.7.9.2 0.0000000000000000001199 98.0
HKD1_k127_7618268_5 PFAM blue (type 1) copper domain protein - - - 0.000000000000006484 80.0
HKD1_k127_7618268_6 - - - - 0.00000003119 61.0
HKD1_k127_7628818_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412,K03413 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 345.0
HKD1_k127_7628818_1 Signal transducing histidine kinase, homodimeric K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 300.0
HKD1_k127_7628818_2 Methylase of chemotaxis methyl-accepting K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000006233 185.0
HKD1_k127_7628818_3 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000001665 162.0
HKD1_k127_7628818_4 PFAM CheC domain protein K03410 - - 0.00000007383 58.0
HKD1_k127_7671759_0 H( )-stimulated, divalent metal cation uptake system K03322 - - 0.00000000000000000000000000000000000000000000000000001738 197.0
HKD1_k127_7671759_1 phosphoribosyltransferase K07101 - - 0.000000000000000000000000000000000000000001143 160.0
HKD1_k127_7671759_2 - - - - 0.00000000000002991 76.0
HKD1_k127_7684211_0 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 310.0
HKD1_k127_7684211_1 Domain of unknown function (DUF1297) K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000003778 261.0
HKD1_k127_7684211_2 Zinc-dependent metalloprotease - - - 0.0000000000000000004792 99.0
HKD1_k127_7684211_3 mttA/Hcf106 family K03116 - - 0.0000000000000001878 80.0
HKD1_k127_7684211_4 - - - - 0.0000009651 52.0
HKD1_k127_7707337_0 Pfam Transposase IS66 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 452.0
HKD1_k127_7707337_1 Phage tail protein - - - 0.0000000000000000000000000000000000000000000000000000000001362 212.0
HKD1_k127_7707337_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00000000000000000000000000516 128.0
HKD1_k127_774815_0 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 494.0
HKD1_k127_774815_1 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000905 404.0
HKD1_k127_774815_2 NUDIX domain - - - 0.00000000000000000000000000000000000000000001164 165.0
HKD1_k127_774815_3 - - - - 0.00000000000000000000000000000002242 131.0
HKD1_k127_774815_4 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 - 4.1.1.23 0.000000000000000000000000005719 111.0
HKD1_k127_7763380_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 536.0
HKD1_k127_7763380_1 ATPase family associated with various cellular activities (AAA) K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009987 517.0
HKD1_k127_7763380_2 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003758 350.0
HKD1_k127_7763380_3 - - - - 0.00000000000000000000000000000000000000000000000001781 181.0
HKD1_k127_7763380_4 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K18604 - 2.1.3.15,6.4.1.2,6.4.1.3 0.000000000000000000000000000000000000000001173 158.0
HKD1_k127_7763380_5 - K03646 - - 0.0000000000001459 74.0
HKD1_k127_7790708_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 496.0
HKD1_k127_7790708_1 - - - - 0.0000000000000000000000000000000000000000000000000002101 191.0
HKD1_k127_7790708_2 Bacterial Fe(2+) trafficking - - - 0.00000000000000000000000000000000000002814 144.0
HKD1_k127_7790708_3 - - - - 0.00000000000000000000000001984 109.0
HKD1_k127_7790708_4 - - - - 0.0000000000000008983 78.0
HKD1_k127_7829314_0 MGS-like domain K01955 - 6.3.5.5 1.079e-217 681.0
HKD1_k127_7829314_1 Belongs to the GARS family K01945 - 6.3.4.13 2.538e-198 625.0
HKD1_k127_7829314_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 428.0
HKD1_k127_7829314_3 Calcineurin-like phosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 308.0
HKD1_k127_7829314_4 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000001241 191.0
HKD1_k127_7829314_5 - - - - 0.00000000000000000000000000000000000001598 145.0
HKD1_k127_7829314_6 - - - - 0.000000000000000000000000249 108.0
HKD1_k127_7829314_7 Cupin domain - - - 0.0000000000000000000000007732 105.0
HKD1_k127_7835259_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1547.0
HKD1_k127_7835259_1 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000001194 154.0
HKD1_k127_7844362_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 402.0
HKD1_k127_7844362_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 334.0
HKD1_k127_7844362_2 Domain of unknown function (DUF309) K09763 - - 0.000000000000000000000000000000000000000000000000000000006013 203.0
HKD1_k127_7844362_3 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000008433 181.0
HKD1_k127_7844362_4 DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - 0.0000000000000000000000000000000000000005644 155.0
HKD1_k127_7844362_5 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000000000001375 141.0
HKD1_k127_7844362_6 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.0000000000000000000002126 96.0
HKD1_k127_7848670_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 GO:0000166,GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005488,GO:0006082,GO:0006103,GO:0006520,GO:0006536,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016043,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0022607,GO:0034214,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051259,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070402,GO:0070403,GO:0070404,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901605 1.4.1.2,1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 446.0
HKD1_k127_7848670_1 major facilitator superfamily K08153,K08221 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 359.0
HKD1_k127_7848670_2 mttA/Hcf106 family K03116 - - 0.0000000000000000000000001692 109.0
HKD1_k127_7865602_0 Iron-sulfur cluster assembly accessory protein K13628 - - 0.000000000000000000000000000000000000000000000000000004043 191.0
HKD1_k127_7865602_1 - - - - 0.00000000000000000000000000001871 118.0
HKD1_k127_7865602_3 VIT family - - - 0.0000000005531 64.0
HKD1_k127_7894114_0 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000000000000001358 174.0
HKD1_k127_7894114_1 - - - - 0.000000000000000000000000000000315 128.0
HKD1_k127_7894114_2 COG1522 Transcriptional regulators - - - 0.000000000000001004 79.0
HKD1_k127_7895754_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 468.0
HKD1_k127_7895754_2 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000005464 179.0
HKD1_k127_7895754_3 - - - - 0.000000000000000000000000003707 113.0
HKD1_k127_7895754_4 - - - - 0.00000000000000000000003275 102.0
HKD1_k127_7895754_5 - - - - 0.00000000000000000002585 92.0
HKD1_k127_7895754_6 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0006075 50.0
HKD1_k127_7929761_0 DNA Topoisomerase I (eukaryota) K03163 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 519.0
HKD1_k127_7932245_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000797 393.0
HKD1_k127_7932245_1 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007402 342.0
HKD1_k127_7932245_2 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001202 275.0
HKD1_k127_7932245_3 Tetrapyrrole (Corrin/Porphyrin) Methylases K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000000000000000000000000007855 170.0
HKD1_k127_7932245_4 - - - - 0.0000000000000103 79.0
HKD1_k127_7938447_0 Belongs to the peptidase S8 family K14647 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009372 610.0
HKD1_k127_7938447_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 459.0
HKD1_k127_7938447_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 334.0
HKD1_k127_7938447_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000000002929 144.0
HKD1_k127_7938447_4 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.0000000001998 61.0
HKD1_k127_7967344_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 7.717e-237 749.0
HKD1_k127_7967344_1 aspartate carbamoyltransferase K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 467.0
HKD1_k127_7967344_2 PFAM ABC transporter K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 342.0
HKD1_k127_7967344_3 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 328.0
HKD1_k127_7967344_4 Periplasmic solute binding protein K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 307.0
HKD1_k127_7967344_5 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005313 246.0
HKD1_k127_7967344_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000636 195.0
HKD1_k127_7967344_7 Ribbon-helix-helix protein, copG family K07722 - - 0.000000000000000000000000000000000000000000000000002905 184.0
HKD1_k127_7967344_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000005033 160.0
HKD1_k127_7974675_0 HELICc2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009163 573.0
HKD1_k127_7974675_1 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 498.0
HKD1_k127_7974675_10 Belongs to the UPF0201 family K09736 - - 0.00000000000000000000000000000000009752 137.0
HKD1_k127_7974675_12 zinc finger - - - 0.000000000000000000000000003124 112.0
HKD1_k127_7974675_13 - - - - 0.000000000000003436 78.0
HKD1_k127_7974675_14 - - - - 0.000000008131 66.0
HKD1_k127_7974675_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009892 462.0
HKD1_k127_7974675_3 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 436.0
HKD1_k127_7974675_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005356 357.0
HKD1_k127_7974675_5 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003376 240.0
HKD1_k127_7974675_6 protein conserved in archaea K09723 - - 0.00000000000000000000000000000000000000000000000000000000001103 211.0
HKD1_k127_7974675_7 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000002799 194.0
HKD1_k127_7974675_8 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000001393 190.0
HKD1_k127_7974675_9 Ser thr protein kinase K07176 - - 0.0000000000000000000000000000000000000000000000001315 186.0
HKD1_k127_7974987_0 Tfp pilus assembly protein FimV - - - 0.00000000000000000000000000000000000000000000000000000000001719 227.0
HKD1_k127_8008568_0 component I K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 334.0
HKD1_k127_8008568_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.00000000000000000000000000000000000000000000003237 171.0
HKD1_k127_8021186_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008824 364.0
HKD1_k127_8021186_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00002856 46.0
HKD1_k127_8037012_0 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000006465 258.0
HKD1_k127_8037012_1 - - - - 0.000000000000000000000000000000000000000002381 158.0
HKD1_k127_8037012_2 - - - - 0.0000000000000000000000000000000000001482 147.0
HKD1_k127_8037012_3 AbrB family - - - 0.000000000001039 68.0
HKD1_k127_831364_0 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000001026 79.0
HKD1_k127_861186_0 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001458 281.0
HKD1_k127_861186_1 Cupin domain - - - 0.00000000000000000003369 91.0
HKD1_k127_861186_2 LamG domain protein jellyroll fold domain protein K12567 - 2.7.11.1 0.00000002055 63.0
HKD1_k127_861186_3 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000001387 57.0
HKD1_k127_932617_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004145 400.0
HKD1_k127_932617_1 synthetase (class II) K01880 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000001763 217.0
HKD1_k127_932617_2 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000002637 206.0
HKD1_k127_950534_0 thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000002808 231.0
HKD1_k127_950534_1 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.000000000000000000000000000000000000000007061 159.0
HKD1_k127_950534_2 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000001493 117.0
HKD1_k127_95514_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000001094 209.0
HKD1_k127_95514_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412,K03413 - 3.1.1.61,3.5.1.44 0.0000001551 58.0
HKD1_k127_957288_0 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 378.0
HKD1_k127_957288_1 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 335.0
HKD1_k127_957288_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 301.0
HKD1_k127_957288_3 riboflavin synthase, alpha K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000005898 266.0
HKD1_k127_957288_4 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000206 194.0
HKD1_k127_957288_5 Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity K08096 - 3.5.4.29 0.0000000000000000000000000000000000000000000003129 169.0