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Overview

ID MAG01770
Name HKD2_bin.1
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Sphingomonadales
Family Sphingomonadaceae
Genus Sphingomicrobium
Species
Assembly information
Completeness (%) 99.8
Contamination (%) 1.23
GC content (%) 62.0
N50 (bp) 63,337
Genome size (bp) 2,765,162

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2674

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10102200_0 NMT1-like family - - - 1.52e-244 766.0
HKD2_k127_10102200_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009201 278.0
HKD2_k127_10102200_2 Tetratricopeptide repeat - - - 0.000000000000000000000000001465 117.0
HKD2_k127_10102200_3 ABC transporter substrate binding protein K01989 - - 0.00000000000002155 74.0
HKD2_k127_1044586_0 Amidohydrolase family - - - 0.0 1324.0
HKD2_k127_1044586_1 Transketolase, thiamine diphosphate binding domain K00163 - 1.2.4.1 0.0 1172.0
HKD2_k127_1044586_10 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 466.0
HKD2_k127_1044586_11 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 428.0
HKD2_k127_1044586_12 exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 383.0
HKD2_k127_1044586_13 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004282 391.0
HKD2_k127_1044586_14 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 331.0
HKD2_k127_1044586_15 Phenazine biosynthesis-like protein K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 292.0
HKD2_k127_1044586_16 Phage shock protein A K03969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001357 270.0
HKD2_k127_1044586_17 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003805 265.0
HKD2_k127_1044586_18 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003543 237.0
HKD2_k127_1044586_19 AntiSigma factor - - - 0.00000000000000000000000000000000000000000000000000000000000000002379 232.0
HKD2_k127_1044586_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.175e-299 929.0
HKD2_k127_1044586_20 conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000008701 222.0
HKD2_k127_1044586_21 mRNA catabolic process K06950 - - 0.0000000000000000000000000000000000000000000000000000000914 203.0
HKD2_k127_1044586_22 - - - - 0.00000000000000000000000000000000000000000000000000007287 188.0
HKD2_k127_1044586_23 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000003505 185.0
HKD2_k127_1044586_24 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000000000403 171.0
HKD2_k127_1044586_25 Protein of unknown function (DUF3297) - - - 0.000000000000000000000000000000000002938 141.0
HKD2_k127_1044586_26 - - - - 0.0000000000000000000000000000001346 131.0
HKD2_k127_1044586_27 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000004057 125.0
HKD2_k127_1044586_28 - - - - 0.0000000000000000000000001736 113.0
HKD2_k127_1044586_29 Protein of unknown function (DUF3833) - - - 0.0000000000000000000000005963 113.0
HKD2_k127_1044586_3 cytochrome c biogenesis protein - - - 1.22e-222 703.0
HKD2_k127_1044586_30 - - - - 0.0000000000000000003026 93.0
HKD2_k127_1044586_31 positive regulation of macromolecule biosynthetic process K03973 - - 0.000000000000000007995 88.0
HKD2_k127_1044586_32 - - - - 0.0000000000000002306 82.0
HKD2_k127_1044586_33 - - - - 0.00005384 48.0
HKD2_k127_1044586_4 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 1.704e-219 694.0
HKD2_k127_1044586_5 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 603.0
HKD2_k127_1044586_6 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006499 565.0
HKD2_k127_1044586_7 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K09699 - 2.3.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 552.0
HKD2_k127_1044586_8 Major Facilitator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 468.0
HKD2_k127_1044586_9 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 464.0
HKD2_k127_1302467_0 TonB dependent receptor K02014 - - 0.0 1060.0
HKD2_k127_1302467_1 PQQ-like domain K05889 - 1.1.2.6 3.343e-268 839.0
HKD2_k127_1302467_10 Transketolase, pyrimidine binding domain K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 572.0
HKD2_k127_1302467_11 Dehydrogenase E1 component K21416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 522.0
HKD2_k127_1302467_12 acetyl-coa acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 516.0
HKD2_k127_1302467_13 pyridine nucleotide-disulfide oxidoreductase K00529 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 493.0
HKD2_k127_1302467_14 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007399 492.0
HKD2_k127_1302467_15 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 482.0
HKD2_k127_1302467_16 KR domain K13774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 428.0
HKD2_k127_1302467_17 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 414.0
HKD2_k127_1302467_18 Enoyl-(Acyl carrier protein) reductase K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 374.0
HKD2_k127_1302467_19 Protein of unknown function (DUF692) K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 357.0
HKD2_k127_1302467_2 AMP-dependent synthetase and ligase K00666 - - 1.958e-258 809.0
HKD2_k127_1302467_20 Trehalose utilisation K09992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 347.0
HKD2_k127_1302467_21 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 346.0
HKD2_k127_1302467_22 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000609 336.0
HKD2_k127_1302467_23 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008158 331.0
HKD2_k127_1302467_24 Enoyl-(Acyl carrier protein) reductase K05296 - 1.1.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 327.0
HKD2_k127_1302467_25 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 336.0
HKD2_k127_1302467_26 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 308.0
HKD2_k127_1302467_27 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004873 280.0
HKD2_k127_1302467_28 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006212 263.0
HKD2_k127_1302467_29 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005323 257.0
HKD2_k127_1302467_3 Ring hydroxylating alpha subunit (catalytic domain) - - - 4.154e-222 695.0
HKD2_k127_1302467_30 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002696 254.0
HKD2_k127_1302467_31 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003569 247.0
HKD2_k127_1302467_32 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003454 249.0
HKD2_k127_1302467_33 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000000000577 237.0
HKD2_k127_1302467_34 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000001372 225.0
HKD2_k127_1302467_35 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000003121 202.0
HKD2_k127_1302467_36 KR domain - - - 0.0000000000000000000000000000000000000000000000000000001068 203.0
HKD2_k127_1302467_37 - - - - 0.00000000000000000000000000000000000000000000000000001651 194.0
HKD2_k127_1302467_38 DoxX K15977 - - 0.0000000000000000000000000000000000000000000000000006038 187.0
HKD2_k127_1302467_39 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000000000000000000000000000000001042 183.0
HKD2_k127_1302467_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.459e-221 694.0
HKD2_k127_1302467_40 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000007955 182.0
HKD2_k127_1302467_41 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000000009969 179.0
HKD2_k127_1302467_42 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000000000000000000007343 171.0
HKD2_k127_1302467_43 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000705 168.0
HKD2_k127_1302467_44 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000002756 164.0
HKD2_k127_1302467_45 Cupin - - - 0.0000000000000000000000000000000000002669 147.0
HKD2_k127_1302467_46 ferredoxin K04755 - - 0.00000000000000000000000000000000000253 143.0
HKD2_k127_1302467_47 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000004175 133.0
HKD2_k127_1302467_48 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000001504 129.0
HKD2_k127_1302467_49 Predicted integral membrane protein (DUF2282) - - - 0.0000000000000000000000000001181 120.0
HKD2_k127_1302467_5 Ring hydroxylating alpha subunit (catalytic domain) - - - 8.308e-219 685.0
HKD2_k127_1302467_50 Putative DNA-binding domain - - - 0.0000000000000000000000000001197 124.0
HKD2_k127_1302467_51 hydroperoxide reductase activity K04756 - - 0.0000000000000000000000000001812 122.0
HKD2_k127_1302467_52 carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000005213 130.0
HKD2_k127_1302467_53 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.000000000000000000000000000609 119.0
HKD2_k127_1302467_54 Ribosomal protein L30 K02907 - - 0.0000000000000000000007701 100.0
HKD2_k127_1302467_55 histidine kinase, dimerisation and phosphoacceptor region - - - 0.00000001602 67.0
HKD2_k127_1302467_6 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 6.932e-197 624.0
HKD2_k127_1302467_7 FAD linked - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006697 600.0
HKD2_k127_1302467_8 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 592.0
HKD2_k127_1302467_9 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 583.0
HKD2_k127_1335349_0 Dehydratase family K01687,K22186 - 4.2.1.82,4.2.1.9 1.132e-294 914.0
HKD2_k127_1335349_1 Fumarylacetoacetate (FAA) hydrolase family K01826 - 5.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 453.0
HKD2_k127_1335349_2 Glucose dehydrogenase C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 398.0
HKD2_k127_1335349_3 ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 363.0
HKD2_k127_1335349_4 Enoyl-(Acyl carrier protein) reductase K00019,K18335 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 329.0
HKD2_k127_1335349_5 Anabaena sensory rhodopsin transducer - - - 0.00000000000000000000000000000000000000000000001654 175.0
HKD2_k127_1405884_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1084.0
HKD2_k127_1405884_1 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 5.289e-299 922.0
HKD2_k127_1405884_10 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 406.0
HKD2_k127_1405884_11 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005757 387.0
HKD2_k127_1405884_12 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 378.0
HKD2_k127_1405884_13 Peptidase S41 K00405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006507 367.0
HKD2_k127_1405884_14 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 345.0
HKD2_k127_1405884_15 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 357.0
HKD2_k127_1405884_16 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 338.0
HKD2_k127_1405884_17 GcrA cell cycle regulator K13583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 330.0
HKD2_k127_1405884_18 Nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 319.0
HKD2_k127_1405884_19 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 302.0
HKD2_k127_1405884_2 P-type ATPase K01533 - 3.6.3.4 1.64e-243 775.0
HKD2_k127_1405884_20 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009198 277.0
HKD2_k127_1405884_21 Cupin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006465 265.0
HKD2_k127_1405884_22 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000007441 238.0
HKD2_k127_1405884_23 N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006724 237.0
HKD2_k127_1405884_24 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000102 233.0
HKD2_k127_1405884_25 Disulfide bond formation protein DsbB - - - 0.000000000000000000000000000000000000000000000000000000000001511 214.0
HKD2_k127_1405884_26 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.0000000000000000000000000000000000000000000000000000000003154 208.0
HKD2_k127_1405884_27 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000003117 198.0
HKD2_k127_1405884_28 thioesterase K07107 - - 0.00000000000000000000000000000000000000000000000000000004602 198.0
HKD2_k127_1405884_29 - - - - 0.00000000000000000000000000000000000000000000000000002675 195.0
HKD2_k127_1405884_3 Nitrogen fixation protein fixG - - - 2.217e-222 699.0
HKD2_k127_1405884_30 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000568 172.0
HKD2_k127_1405884_31 Integral membrane protein linked to a cation - - - 0.0000000000000000000000000000000004105 138.0
HKD2_k127_1405884_32 TIR domain - - - 0.000000000000000000000000000000006035 147.0
HKD2_k127_1405884_33 - - - - 0.00000000000000000000000000008876 117.0
HKD2_k127_1405884_34 oxidation-reduction process K09022 - 3.5.99.10 0.0000000000000000000000000001046 120.0
HKD2_k127_1405884_35 - - - - 0.0000000000000000000000000001601 119.0
HKD2_k127_1405884_36 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000000000000213 92.0
HKD2_k127_1405884_38 - - - - 0.00000000000000001035 93.0
HKD2_k127_1405884_39 - - - - 0.000000000000006966 80.0
HKD2_k127_1405884_4 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 2.185e-211 661.0
HKD2_k127_1405884_42 Cytochrome oxidase maturation protein cbb3-type - - - 0.0000000000001477 76.0
HKD2_k127_1405884_43 EF-hand, calcium binding motif - - - 0.000000001513 64.0
HKD2_k127_1405884_44 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.00000001285 59.0
HKD2_k127_1405884_45 Penicillinase repressor - - - 0.00000003136 61.0
HKD2_k127_1405884_48 Transcriptional regulatory protein, C terminal - - - 0.00002968 57.0
HKD2_k127_1405884_49 EF-hand domain pair - - - 0.00041 49.0
HKD2_k127_1405884_5 Methionine aminopeptidase K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 487.0
HKD2_k127_1405884_6 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005408 451.0
HKD2_k127_1405884_7 coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 453.0
HKD2_k127_1405884_8 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 438.0
HKD2_k127_1405884_9 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007343 436.0
HKD2_k127_1441662_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 505.0
HKD2_k127_1441662_1 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 320.0
HKD2_k127_1441662_2 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 282.0
HKD2_k127_1441662_3 2-methylthioadenine K18707 - 2.8.4.5 0.0000000000000000000000000000000000000000000001745 171.0
HKD2_k127_1451283_0 Phage integrase, N-terminal SAM-like domain - - - 3.162e-195 611.0
HKD2_k127_1451283_1 Phage integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008887 597.0
HKD2_k127_1451283_2 Phage integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009206 574.0
HKD2_k127_1451283_3 Transposase K07484 - - 0.00000000000000005068 83.0
HKD2_k127_1451283_4 Transposase K07484 - - 0.00001903 49.0
HKD2_k127_1548231_0 Belongs to the peptidase S16 family - - - 1.24e-321 1003.0
HKD2_k127_1548231_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - 7.961e-267 829.0
HKD2_k127_1548231_2 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 333.0
HKD2_k127_1548231_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000000000264 196.0
HKD2_k127_1548231_4 - - - - 0.0000000000000001734 90.0
HKD2_k127_1548231_5 - - - - 0.0000000000004708 69.0
HKD2_k127_1548231_6 - - - - 0.00000000005582 63.0
HKD2_k127_1548231_7 Protein of unknown function (DUF3775) - - - 0.0000323 51.0
HKD2_k127_1645861_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1286.0
HKD2_k127_1645861_1 NADH ubiquinone oxidoreductase subunit K00341 - 1.6.5.3 0.0 1088.0
HKD2_k127_1645861_10 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.093e-238 748.0
HKD2_k127_1645861_11 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 1.205e-236 741.0
HKD2_k127_1645861_12 response regulator - - - 1.881e-232 732.0
HKD2_k127_1645861_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 1.997e-230 719.0
HKD2_k127_1645861_14 5-aminolevulinic acid synthase K00643 - 2.3.1.37 5.001e-223 696.0
HKD2_k127_1645861_15 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 6.834e-213 675.0
HKD2_k127_1645861_16 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 6.043e-204 640.0
HKD2_k127_1645861_17 peptidase - - - 6.007e-197 633.0
HKD2_k127_1645861_18 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 591.0
HKD2_k127_1645861_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 586.0
HKD2_k127_1645861_2 NADH-quinone oxidoreductase K00336 - 1.6.5.3 0.0 1077.0
HKD2_k127_1645861_20 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 561.0
HKD2_k127_1645861_21 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 560.0
HKD2_k127_1645861_22 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 523.0
HKD2_k127_1645861_23 N-carbamoylputrescine amidase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 501.0
HKD2_k127_1645861_24 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 491.0
HKD2_k127_1645861_25 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 488.0
HKD2_k127_1645861_26 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 478.0
HKD2_k127_1645861_27 Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis K01623 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 455.0
HKD2_k127_1645861_28 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 447.0
HKD2_k127_1645861_29 membrane-bound lytic murein transglycosylase K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 451.0
HKD2_k127_1645861_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0 1054.0
HKD2_k127_1645861_30 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006433 428.0
HKD2_k127_1645861_31 glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 409.0
HKD2_k127_1645861_32 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008361 378.0
HKD2_k127_1645861_33 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000033 392.0
HKD2_k127_1645861_34 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004892 376.0
HKD2_k127_1645861_35 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 376.0
HKD2_k127_1645861_36 NADH dehydrogenase K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008915 362.0
HKD2_k127_1645861_37 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006931 355.0
HKD2_k127_1645861_38 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 352.0
HKD2_k127_1645861_39 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000707 346.0
HKD2_k127_1645861_4 Belongs to the transketolase family K00615 - 2.2.1.1 1.432e-320 992.0
HKD2_k127_1645861_40 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 341.0
HKD2_k127_1645861_41 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 335.0
HKD2_k127_1645861_42 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 336.0
HKD2_k127_1645861_43 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 336.0
HKD2_k127_1645861_44 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000985 318.0
HKD2_k127_1645861_45 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006399 318.0
HKD2_k127_1645861_47 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009348 306.0
HKD2_k127_1645861_48 aspartate racemase K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 303.0
HKD2_k127_1645861_49 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 303.0
HKD2_k127_1645861_5 Bacterial protein of unknown function (DUF885) - - - 4.563e-269 841.0
HKD2_k127_1645861_50 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 308.0
HKD2_k127_1645861_51 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007966 299.0
HKD2_k127_1645861_52 O-Antigen ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003081 290.0
HKD2_k127_1645861_53 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K07313 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008841 279.0
HKD2_k127_1645861_54 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004329 276.0
HKD2_k127_1645861_55 import inner membrane translocase, subunit Tim44 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004834 274.0
HKD2_k127_1645861_56 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002144 272.0
HKD2_k127_1645861_57 polysaccharide export K01991 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008536 274.0
HKD2_k127_1645861_58 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002532 267.0
HKD2_k127_1645861_59 Cell Wall Hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001963 274.0
HKD2_k127_1645861_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.821e-263 813.0
HKD2_k127_1645861_60 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002876 273.0
HKD2_k127_1645861_61 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000000000005429 238.0
HKD2_k127_1645861_62 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000005737 224.0
HKD2_k127_1645861_63 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000002304 230.0
HKD2_k127_1645861_64 Prolyl 4-hydroxylase alpha subunit homologues. K00472 - 1.14.11.2 0.00000000000000000000000000000000000000000000000000000000000000127 226.0
HKD2_k127_1645861_65 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000003834 220.0
HKD2_k127_1645861_66 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000000000000000000000000000000000000004194 217.0
HKD2_k127_1645861_67 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000003332 223.0
HKD2_k127_1645861_68 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000009489 200.0
HKD2_k127_1645861_69 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000000000000000001772 204.0
HKD2_k127_1645861_7 protein involved in exopolysaccharide biosynthesis - - - 2.752e-251 796.0
HKD2_k127_1645861_70 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000003111 200.0
HKD2_k127_1645861_71 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000000000000000000000000000000000001252 192.0
HKD2_k127_1645861_72 protein affecting Mg2 Co2 transport K06195 - - 0.00000000000000000000000000000000000000000000000000002667 190.0
HKD2_k127_1645861_73 COG0739 Membrane proteins related to metalloendopeptidases K21472 - - 0.0000000000000000000000000000000000000000000000000002884 194.0
HKD2_k127_1645861_74 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000003511 197.0
HKD2_k127_1645861_75 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000004486 177.0
HKD2_k127_1645861_76 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000085 171.0
HKD2_k127_1645861_77 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000001073 168.0
HKD2_k127_1645861_78 nad(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000003578 160.0
HKD2_k127_1645861_79 COG2801 Transposase and inactivated derivatives K07497 - - 0.000000000000000000000000000000000000000001736 158.0
HKD2_k127_1645861_8 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 6.527e-248 774.0
HKD2_k127_1645861_80 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000003329 156.0
HKD2_k127_1645861_81 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000008612 144.0
HKD2_k127_1645861_82 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000000000004838 129.0
HKD2_k127_1645861_83 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000000000000000000002822 128.0
HKD2_k127_1645861_84 - - - - 0.00000000000000000000000000000003013 140.0
HKD2_k127_1645861_85 protein conserved in bacteria - - - 0.0000000000000000000000000000002297 129.0
HKD2_k127_1645861_86 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000000000000002381 124.0
HKD2_k127_1645861_87 ParE toxin of type II toxin-antitoxin system, parDE K19092 - - 0.0000000000000000000000000000109 123.0
HKD2_k127_1645861_88 addiction module - - - 0.0000000000000000000000000001051 118.0
HKD2_k127_1645861_89 PFAM Exopolysaccharide synthesis ExoD - - - 0.0000000000000000000000000006543 121.0
HKD2_k127_1645861_9 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 1.716e-240 752.0
HKD2_k127_1645861_90 - - - - 0.0000000000000000000000003879 109.0
HKD2_k127_1645861_91 Belongs to the TPP enzyme family K00156 - 1.2.5.1 0.00000000000000000005722 96.0
HKD2_k127_1645861_92 - - - - 0.0000000000000000003062 98.0
HKD2_k127_1645861_93 - - - - 0.0000000000000000003897 96.0
HKD2_k127_1645861_95 Protein of unknown function (DUF2842) - - - 0.000000000000002321 87.0
HKD2_k127_1645861_96 belongs to the thioredoxin family - - - 0.00000000009668 73.0
HKD2_k127_1645861_98 CAAX protease self-immunity - - - 0.0000008634 59.0
HKD2_k127_1645861_99 DnaJ-class molecular chaperone - - - 0.000003503 58.0
HKD2_k127_1676977_0 Efflux pump membrane transporter - - - 0.0 1762.0
HKD2_k127_1676977_1 amine dehydrogenase activity - - - 0.0 1205.0
HKD2_k127_1676977_10 6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 357.0
HKD2_k127_1676977_11 Major Facilitator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009609 341.0
HKD2_k127_1676977_12 COG3210 Large exoproteins involved in heme utilization or adhesion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 358.0
HKD2_k127_1676977_13 Protease prsW family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 321.0
HKD2_k127_1676977_14 TetR family transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004044 270.0
HKD2_k127_1676977_15 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000007344 199.0
HKD2_k127_1676977_17 - - - - 0.00000000000000000000000379 108.0
HKD2_k127_1676977_18 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000000001981 106.0
HKD2_k127_1676977_19 COG2346 Truncated hemoglobins K06886 - - 0.0000000000002516 74.0
HKD2_k127_1676977_2 protein conserved in bacteria - - - 1.22e-287 918.0
HKD2_k127_1676977_20 Protein of unknown function (DUF2501) - - - 0.00000000001827 72.0
HKD2_k127_1676977_21 Stress-induced bacterial acidophilic repeat motif K06884 - - 0.000002986 50.0
HKD2_k127_1676977_3 receptor - - - 2.14e-227 724.0
HKD2_k127_1676977_4 PFAM Outer membrane efflux protein - - - 1.155e-194 617.0
HKD2_k127_1676977_5 COG2831 Hemolysin activation secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006836 547.0
HKD2_k127_1676977_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 526.0
HKD2_k127_1676977_7 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 499.0
HKD2_k127_1676977_8 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 435.0
HKD2_k127_1676977_9 Repeat of Unknown Function (DUF347) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008172 380.0
HKD2_k127_1767365_0 ammonium transporter K03320 - - 4.975e-194 613.0
HKD2_k127_1767365_1 Resolvase K06400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 323.0
HKD2_k127_1767365_2 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001008 227.0
HKD2_k127_1767365_3 Protein of unknown function (DUF2924) - - - 0.00000000000000000000000000000000000000000000000001008 185.0
HKD2_k127_1767365_4 - - - - 0.00000000000000000000000003426 112.0
HKD2_k127_1767365_5 Protein of unknown function (DUF3489) - - - 0.00000000000000000000002342 101.0
HKD2_k127_1792044_0 Belongs to the UPF0276 family K09930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 370.0
HKD2_k127_1792044_1 Transposase IS116/IS110/IS902 family K07486 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 362.0
HKD2_k127_1792044_2 Putative DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002331 235.0
HKD2_k127_1792044_3 Protein of unknown function (DUF1223) - - - 0.00000000000000000000000000000000000000000000000000000000000000002021 231.0
HKD2_k127_1792044_4 Protein of unknown function (DUF1109) - - - 0.000000000000000000000000000000000000000000000000000000000000007795 222.0
HKD2_k127_1792044_5 - - - - 0.000000000000000000000000000000000000000000000002312 177.0
HKD2_k127_1792044_6 Predicted integral membrane protein (DUF2282) - - - 0.0000000000000000000000000001554 120.0
HKD2_k127_1792044_7 - - - - 0.000000000000000000000000002716 114.0
HKD2_k127_1792044_8 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000164 74.0
HKD2_k127_1792044_9 LysE type translocator - - - 0.000000001166 67.0
HKD2_k127_1811572_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 351.0
HKD2_k127_1811572_1 Pfam Transposase IS66 - - - 0.00000000000000000000000000000000000000000000002739 188.0
HKD2_k127_1819584_0 COG2801 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 413.0
HKD2_k127_1819584_1 Transposase - - - 0.000000000000000000000000000000000000001745 148.0
HKD2_k127_1819584_2 Major facilitator Superfamily - - - 0.00000001153 59.0
HKD2_k127_1911194_0 Transposase DDE domain - - - 2.113e-209 659.0
HKD2_k127_1911194_1 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007046 494.0
HKD2_k127_1968704_0 chemotaxis protein K03407 - 2.7.13.3 0.0 1074.0
HKD2_k127_1968704_1 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 560.0
HKD2_k127_1968704_10 Carboxylesterase family - - - 0.0000000000002491 70.0
HKD2_k127_1968704_2 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 419.0
HKD2_k127_1968704_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 427.0
HKD2_k127_1968704_4 COG1352 Methylase of chemotaxis methyl-accepting proteins K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007678 411.0
HKD2_k127_1968704_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 398.0
HKD2_k127_1968704_6 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 331.0
HKD2_k127_1968704_7 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000000000000000000000001446 237.0
HKD2_k127_1968704_8 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.000000000000000000000000000000000000000000000000000000000000000146 239.0
HKD2_k127_1968704_9 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000000000000000000000000000000009347 211.0
HKD2_k127_2240356_0 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 5.43e-204 643.0
HKD2_k127_2240356_1 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000006598 129.0
HKD2_k127_228392_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1404.0
HKD2_k127_228392_1 DNA ligase K01971 - 6.5.1.1 0.0 1208.0
HKD2_k127_228392_10 amino acid peptide transporter K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009461 605.0
HKD2_k127_228392_11 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005329 584.0
HKD2_k127_228392_12 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 573.0
HKD2_k127_228392_13 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 526.0
HKD2_k127_228392_14 beta-glucosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 511.0
HKD2_k127_228392_15 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 503.0
HKD2_k127_228392_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003984 506.0
HKD2_k127_228392_17 YjgP YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 501.0
HKD2_k127_228392_18 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 449.0
HKD2_k127_228392_19 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 427.0
HKD2_k127_228392_2 COG2366 Protein related to penicillin acylase - - - 1.381e-305 958.0
HKD2_k127_228392_20 YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 415.0
HKD2_k127_228392_21 Diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009648 405.0
HKD2_k127_228392_22 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 400.0
HKD2_k127_228392_23 Belongs to the glycosyl hydrolase 43 family K06113 - 3.2.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 398.0
HKD2_k127_228392_24 Predicted metal-dependent hydrolase K07044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 390.0
HKD2_k127_228392_25 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 398.0
HKD2_k127_228392_26 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 383.0
HKD2_k127_228392_27 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 392.0
HKD2_k127_228392_28 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005129 383.0
HKD2_k127_228392_29 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 380.0
HKD2_k127_228392_3 PQQ-like domain K00117 GO:0000287,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008876,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0031224,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044425,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0048039,GO:0055114,GO:0070968,GO:0071944,GO:0097159,GO:1901363 1.1.5.2 1.799e-270 857.0
HKD2_k127_228392_30 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 367.0
HKD2_k127_228392_31 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 365.0
HKD2_k127_228392_32 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine K03648 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 362.0
HKD2_k127_228392_33 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 369.0
HKD2_k127_228392_34 Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 344.0
HKD2_k127_228392_35 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009038 337.0
HKD2_k127_228392_36 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 332.0
HKD2_k127_228392_37 protein conserved in bacteria K09990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 320.0
HKD2_k127_228392_38 RES domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 316.0
HKD2_k127_228392_39 Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 283.0
HKD2_k127_228392_4 Transporter - - - 8.588e-268 839.0
HKD2_k127_228392_40 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001402 284.0
HKD2_k127_228392_41 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003248 276.0
HKD2_k127_228392_42 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000001376 273.0
HKD2_k127_228392_43 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000004187 271.0
HKD2_k127_228392_44 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006712 246.0
HKD2_k127_228392_45 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000000000000000000000006837 227.0
HKD2_k127_228392_46 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000007206 227.0
HKD2_k127_228392_47 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000000005969 216.0
HKD2_k127_228392_48 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000000000000000000000004379 208.0
HKD2_k127_228392_49 - - - - 0.000000000000000000000000000000000000000000000000001173 188.0
HKD2_k127_228392_5 glutamate--cysteine ligase K01919 - 6.3.2.2 4.414e-248 770.0
HKD2_k127_228392_50 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000003821 181.0
HKD2_k127_228392_51 small integral membrane protein - - - 0.0000000000000000000000000000000000000000000000007124 179.0
HKD2_k127_228392_52 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000000000000000000653 167.0
HKD2_k127_228392_53 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000003084 163.0
HKD2_k127_228392_54 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000002003 161.0
HKD2_k127_228392_55 Predicted membrane protein (DUF2127) - - - 0.000000000000000000000000000000000002003 142.0
HKD2_k127_228392_56 Protein of unknown function (DUF3035) - - - 0.0000000000000000000000000000000001157 137.0
HKD2_k127_228392_57 acyl carrier protein - - - 0.00000000000000000000000000000001714 130.0
HKD2_k127_228392_58 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000001591 102.0
HKD2_k127_228392_59 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.000000000000000556 81.0
HKD2_k127_228392_6 Histidine kinase - - - 8.906e-234 740.0
HKD2_k127_228392_60 - - - - 0.0000000000000005587 87.0
HKD2_k127_228392_62 - - - - 0.0000003344 55.0
HKD2_k127_228392_63 DnaJ molecular chaperone homology domain - - - 0.0000003857 62.0
HKD2_k127_228392_7 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes K00639,K00652 - 2.3.1.29,2.3.1.47 4.236e-226 704.0
HKD2_k127_228392_8 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 8.067e-213 681.0
HKD2_k127_228392_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 2.099e-198 621.0
HKD2_k127_2304178_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1335.0
HKD2_k127_2304178_1 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.0 1054.0
HKD2_k127_2304178_10 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 606.0
HKD2_k127_2304178_11 Mate efflux family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 599.0
HKD2_k127_2304178_12 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005937 589.0
HKD2_k127_2304178_13 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) K01484 - 3.5.3.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 599.0
HKD2_k127_2304178_14 membrane K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 574.0
HKD2_k127_2304178_15 peptidase M48, Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 570.0
HKD2_k127_2304178_16 synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 564.0
HKD2_k127_2304178_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 563.0
HKD2_k127_2304178_18 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008224 524.0
HKD2_k127_2304178_19 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 513.0
HKD2_k127_2304178_2 peptidase S9 - - - 1.4e-322 999.0
HKD2_k127_2304178_20 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 513.0
HKD2_k127_2304178_21 arginine N-succinyltransferase K00673 - 2.3.1.109 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 511.0
HKD2_k127_2304178_22 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007247 488.0
HKD2_k127_2304178_23 Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 467.0
HKD2_k127_2304178_24 alpha/beta hydrolase fold K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 461.0
HKD2_k127_2304178_25 Protein of unknown function (DUF3570) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 469.0
HKD2_k127_2304178_26 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 448.0
HKD2_k127_2304178_27 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 430.0
HKD2_k127_2304178_28 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 408.0
HKD2_k127_2304178_29 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 398.0
HKD2_k127_2304178_3 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 3.625e-318 990.0
HKD2_k127_2304178_30 Belongs to the 'phage' integrase family K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 399.0
HKD2_k127_2304178_31 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 394.0
HKD2_k127_2304178_32 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007529 378.0
HKD2_k127_2304178_33 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 376.0
HKD2_k127_2304178_34 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 374.0
HKD2_k127_2304178_35 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 317.0
HKD2_k127_2304178_36 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 309.0
HKD2_k127_2304178_37 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 312.0
HKD2_k127_2304178_38 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005684 307.0
HKD2_k127_2304178_39 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 304.0
HKD2_k127_2304178_4 acyl-CoA dehydrogenase - - - 5.154e-280 871.0
HKD2_k127_2304178_40 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009069 270.0
HKD2_k127_2304178_41 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002458 266.0
HKD2_k127_2304178_42 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000239 269.0
HKD2_k127_2304178_43 RES - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004744 264.0
HKD2_k127_2304178_44 RES - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000368 257.0
HKD2_k127_2304178_45 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000008015 252.0
HKD2_k127_2304178_46 Pfam Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001825 228.0
HKD2_k127_2304178_47 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000005933 224.0
HKD2_k127_2304178_48 protein-L-isoaspartate K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000002504 212.0
HKD2_k127_2304178_49 stress protein (general stress protein 26) - - - 0.00000000000000000000000000000000000000000000000000000000003563 210.0
HKD2_k127_2304178_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.462e-259 805.0
HKD2_k127_2304178_50 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000005508 207.0
HKD2_k127_2304178_51 helix_turn_helix, cAMP Regulatory protein - - - 0.00000000000000000000000000000000000000000000000000001989 201.0
HKD2_k127_2304178_52 PFAM MaoC domain protein dehydratase - - - 0.00000000000000000000000000000000000000000000000000232 186.0
HKD2_k127_2304178_53 Colicin V production protein K03558 - - 0.0000000000000000000000000000000000000000000000001385 181.0
HKD2_k127_2304178_54 Putative stress-induced transcription regulator - - - 0.00000000000000000000000000000000000000000000000915 180.0
HKD2_k127_2304178_55 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000001695 177.0
HKD2_k127_2304178_56 Protein of unknown function (DUF2384) - - - 0.00000000000000000000000000000000000001167 149.0
HKD2_k127_2304178_57 protein conserved in bacteria - - - 0.0000000000000000000000000000000000001828 145.0
HKD2_k127_2304178_58 Redoxin domain protein - - - 0.0000000000000000000000000000000000007859 151.0
HKD2_k127_2304178_59 protein conserved in bacteria K09991 - - 0.000000000000000000000000000000000001761 142.0
HKD2_k127_2304178_6 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 2.587e-220 696.0
HKD2_k127_2304178_60 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000001791 136.0
HKD2_k127_2304178_61 - - - - 0.0000000000000000000000000002708 120.0
HKD2_k127_2304178_62 NifU homolog involved in Fe-S cluster formation - - - 0.000000000000000000000000005157 115.0
HKD2_k127_2304178_63 - - - - 0.000000000000000000000000008504 114.0
HKD2_k127_2304178_64 - - - - 0.000000000000000000000001518 105.0
HKD2_k127_2304178_65 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000000000027 109.0
HKD2_k127_2304178_66 - - - - 0.0000000000000000000002121 100.0
HKD2_k127_2304178_67 - - - - 0.0000000000000000000002715 104.0
HKD2_k127_2304178_68 - - - - 0.00000000000000000000218 97.0
HKD2_k127_2304178_69 - - - - 0.00000000000000000001072 96.0
HKD2_k127_2304178_7 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 1.41e-219 711.0
HKD2_k127_2304178_70 Nickel/cobalt transporter regulator - - - 0.000000000000000002903 91.0
HKD2_k127_2304178_71 Chromate transporter K07240 - - 0.0000000000000001297 81.0
HKD2_k127_2304178_72 Domain of unknown function (DUF4266) - - - 0.000000000000008188 78.0
HKD2_k127_2304178_73 cheY-homologous receiver domain - - - 0.00000000000001197 79.0
HKD2_k127_2304178_75 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000000001483 63.0
HKD2_k127_2304178_77 - - - - 0.00000001864 59.0
HKD2_k127_2304178_79 transferase activity, transferring glycosyl groups - - - 0.00001719 46.0
HKD2_k127_2304178_8 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 9.092e-211 673.0
HKD2_k127_2304178_80 - - - - 0.0000695 46.0
HKD2_k127_2304178_9 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 1.024e-198 627.0
HKD2_k127_2355802_0 ftsk spoiiie K03466 - - 3.716e-214 692.0
HKD2_k127_2355802_1 WD domain, G-beta repeat - - - 0.000000000000000000000000000000000001123 160.0
HKD2_k127_2580394_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1796.0
HKD2_k127_2580394_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1449.0
HKD2_k127_2580394_10 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 600.0
HKD2_k127_2580394_11 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 570.0
HKD2_k127_2580394_12 COG4618 ABC-type protease lipase transport system, ATPase and permease components K06148,K12536,K16299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 547.0
HKD2_k127_2580394_13 Phosphotransferase K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 498.0
HKD2_k127_2580394_14 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 448.0
HKD2_k127_2580394_15 TIGRFAM type I secretion membrane fusion protein, HlyD family K02022 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 436.0
HKD2_k127_2580394_16 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 385.0
HKD2_k127_2580394_17 - K18546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006091 372.0
HKD2_k127_2580394_18 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 348.0
HKD2_k127_2580394_19 Belongs to the UPF0301 (AlgH) family K07735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 326.0
HKD2_k127_2580394_2 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1444.0
HKD2_k127_2580394_20 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 310.0
HKD2_k127_2580394_21 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008623 306.0
HKD2_k127_2580394_22 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 309.0
HKD2_k127_2580394_23 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001895 284.0
HKD2_k127_2580394_24 Prolyl 4-hydroxylase alpha subunit homologues. K07336 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005569 277.0
HKD2_k127_2580394_25 Alkyl hydroperoxide reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001879 264.0
HKD2_k127_2580394_26 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000002191 256.0
HKD2_k127_2580394_27 Trypsin-like peptidase domain K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000008218 254.0
HKD2_k127_2580394_28 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000006507 238.0
HKD2_k127_2580394_29 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000005961 235.0
HKD2_k127_2580394_3 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.0 1071.0
HKD2_k127_2580394_30 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000006625 223.0
HKD2_k127_2580394_31 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000004825 228.0
HKD2_k127_2580394_32 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000000000000000000000000000000000000302 214.0
HKD2_k127_2580394_33 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000001908 207.0
HKD2_k127_2580394_34 - - - - 0.0000000000000000000000000000000000000000000000000001545 200.0
HKD2_k127_2580394_35 - K03832 - - 0.0000000000000000000000000000000000000000000000001417 186.0
HKD2_k127_2580394_36 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000006788 188.0
HKD2_k127_2580394_37 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000121 171.0
HKD2_k127_2580394_38 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000000000000000000001059 136.0
HKD2_k127_2580394_4 helicase K16899 - 3.6.4.12 0.0 1022.0
HKD2_k127_2580394_40 ATPase or kinase K06925,K07102 - 2.7.1.221 0.00000000000000000000000005235 112.0
HKD2_k127_2580394_42 PspC domain protein - - - 0.00000000000003398 79.0
HKD2_k127_2580394_44 - - - - 0.00000000000425 74.0
HKD2_k127_2580394_48 Predicted integral membrane protein (DUF2189) - - - 0.0000132 49.0
HKD2_k127_2580394_5 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 3.715e-317 983.0
HKD2_k127_2580394_6 Histidine kinase - - - 2.924e-282 887.0
HKD2_k127_2580394_7 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 9.073e-273 842.0
HKD2_k127_2580394_8 Protein of unknown function (DUF1343) - - - 4.934e-222 696.0
HKD2_k127_2580394_9 methyl-accepting chemotaxis protein K03406 - - 1.44e-217 686.0
HKD2_k127_2584012_0 cystathionine K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 547.0
HKD2_k127_2584012_1 homoserine dehydrogenase K00003,K12524 - 1.1.1.3,2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008149 334.0
HKD2_k127_2584012_2 Belongs to the AB hydrolase superfamily. MetX family K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.00000000000000000000000000000000000000000002065 167.0
HKD2_k127_2638603_0 Cation transporter/ATPase, N-terminus K01531,K01535 - 3.6.3.2,3.6.3.6 7.258e-293 921.0
HKD2_k127_2638603_1 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008487 371.0
HKD2_k127_2638603_2 Membrane bound O-acyl transferase, MBOAT family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000628 235.0
HKD2_k127_2638603_3 Domain of unknown function (DUF202) K00389 - - 0.0000000000000000000000000001035 123.0
HKD2_k127_2638603_4 Cytochrome c - - - 0.000000000000000000000000006027 116.0
HKD2_k127_2638603_5 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000003771 58.0
HKD2_k127_2659229_0 Major facilitator superfamily K03446 - - 7.467e-222 698.0
HKD2_k127_2659229_1 Secretion protein, HlyD K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 387.0
HKD2_k127_2659229_2 Fic/DOC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002485 237.0
HKD2_k127_2659229_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000001755 174.0
HKD2_k127_2659229_4 TIGRFAM mobile mystery protein A - - - 0.000000000000000000000000000000000000000000001659 169.0
HKD2_k127_2659229_5 YCII-related domain K09780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000001025 55.0
HKD2_k127_2694854_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 363.0
HKD2_k127_2694854_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006055 241.0
HKD2_k127_2694854_2 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000001654 183.0
HKD2_k127_2694854_3 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000001839 122.0
HKD2_k127_2694854_4 - - - - 0.0000000000000000000001896 98.0
HKD2_k127_2694854_5 Outer membrane protein beta-barrel domain - - - 0.0007204 44.0
HKD2_k127_2774605_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1695.0
HKD2_k127_2774605_1 Sulfatase K01130 - 3.1.6.1 0.0 1401.0
HKD2_k127_2774605_10 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 551.0
HKD2_k127_2774605_11 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 496.0
HKD2_k127_2774605_12 Belongs to the NadC ModD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007304 425.0
HKD2_k127_2774605_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 420.0
HKD2_k127_2774605_14 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 330.0
HKD2_k127_2774605_15 proteins, homologs of microcin C7 resistance protein MccF K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 311.0
HKD2_k127_2774605_16 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007995 297.0
HKD2_k127_2774605_17 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 291.0
HKD2_k127_2774605_18 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005864 267.0
HKD2_k127_2774605_19 Methanol dehydrogenase K06872 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009308 246.0
HKD2_k127_2774605_2 Amidohydrolase family - - - 0.0 1129.0
HKD2_k127_2774605_20 - - - - 0.00000000000000000000000000000000000000000000000000000000009201 213.0
HKD2_k127_2774605_21 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000002059 210.0
HKD2_k127_2774605_22 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000000000000000004101 205.0
HKD2_k127_2774605_23 membrane K08988 - - 0.00000000000000000000000000000000000000000000000000000001886 210.0
HKD2_k127_2774605_24 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000003916 203.0
HKD2_k127_2774605_25 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000000000000000000000001504 205.0
HKD2_k127_2774605_26 Nudix hydrolase K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000003937 194.0
HKD2_k127_2774605_27 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000002805 194.0
HKD2_k127_2774605_28 - - - - 0.000000000000000000000000000000000000000000000748 175.0
HKD2_k127_2774605_29 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000001145 175.0
HKD2_k127_2774605_3 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 9.426e-307 946.0
HKD2_k127_2774605_30 - - - - 0.0000000000000000000000000000000000000000001219 169.0
HKD2_k127_2774605_31 - - - - 0.0000000000000000000000000000000000000000007736 166.0
HKD2_k127_2774605_32 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000000001887 156.0
HKD2_k127_2774605_33 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000004625 153.0
HKD2_k127_2774605_34 rhamnose metabolic process - - - 0.00000000000000000000000000000000000008399 143.0
HKD2_k127_2774605_35 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000106 146.0
HKD2_k127_2774605_36 Protein of unknown function (DUF1109) - - - 0.000000000000000000000000000000000008987 143.0
HKD2_k127_2774605_37 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000001979 145.0
HKD2_k127_2774605_38 SWI complex, BAF60b domains - - - 0.00000000000000000000000000001596 123.0
HKD2_k127_2774605_4 acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 2.296e-293 912.0
HKD2_k127_2774605_40 UDP-N-acetylmuramate-alanine ligase K01924 - 6.3.2.8 0.0000000000000000000000317 110.0
HKD2_k127_2774605_42 OmpA family - - - 0.000003465 57.0
HKD2_k127_2774605_43 Adenylate cyclase - - - 0.00002283 57.0
HKD2_k127_2774605_44 - - - - 0.0000527 53.0
HKD2_k127_2774605_5 2-nitropropane dioxygenase - - - 2.538e-281 868.0
HKD2_k127_2774605_6 Amidohydrolase family K06015 - 3.5.1.81 1.64e-248 779.0
HKD2_k127_2774605_7 Peptidase m28 K01269 - - 3.989e-217 688.0
HKD2_k127_2774605_8 Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA K00253 - 1.3.8.4 2.555e-213 668.0
HKD2_k127_2774605_9 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 573.0
HKD2_k127_2912857_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789 - - 0.0 1554.0
HKD2_k127_2912857_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 6.009e-196 619.0
HKD2_k127_2912857_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799,K18990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002288 259.0
HKD2_k127_2947566_0 Penicillin-binding Protein K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004171 569.0
HKD2_k127_2947566_1 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000102 218.0
HKD2_k127_2947566_2 rod shape-determining protein MreD K03571 - - 0.000000000000000000000000000000000000000000000000000000009281 204.0
HKD2_k127_298557_0 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000004429 177.0
HKD2_k127_298557_1 - - - - 0.0000000000000000000000000000000000002964 143.0
HKD2_k127_309643_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0 1261.0
HKD2_k127_309643_1 Sulfotransferase family - - - 4.83e-259 819.0
HKD2_k127_309643_10 Protein of unknown function (DUF1109) - - - 0.0000000000000000000000000000000000000000000000000000325 198.0
HKD2_k127_309643_11 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000004429 184.0
HKD2_k127_309643_12 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000000000002011 176.0
HKD2_k127_309643_13 lactoylglutathione lyase activity K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000002587 156.0
HKD2_k127_309643_14 Thioredoxin-like - - - 0.0000000000000000000000000000000515 130.0
HKD2_k127_309643_15 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000002127 127.0
HKD2_k127_309643_16 PFAM blue (type 1) copper domain protein - - - 0.00000000000000002118 87.0
HKD2_k127_309643_17 Penicillinase repressor - - - 0.00000000132 66.0
HKD2_k127_309643_18 Belongs to the GST superfamily - - - 0.00000001672 60.0
HKD2_k127_309643_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 591.0
HKD2_k127_309643_3 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 514.0
HKD2_k127_309643_4 8-amino-7-oxononanoate synthase K00652 - 2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007844 421.0
HKD2_k127_309643_5 Chalcone and stilbene synthases, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 407.0
HKD2_k127_309643_6 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935,K02169 - 2.1.1.197,6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004095 273.0
HKD2_k127_309643_7 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006595 259.0
HKD2_k127_309643_8 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000001074 220.0
HKD2_k127_309643_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000007081 202.0
HKD2_k127_3150445_0 ATP-dependent helicase K03579 - 3.6.4.13 0.0 1169.0
HKD2_k127_3150445_1 peptidase M13 - - - 0.0 1095.0
HKD2_k127_3150445_10 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 484.0
HKD2_k127_3150445_11 alcohol dehydrogenase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 448.0
HKD2_k127_3150445_12 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 432.0
HKD2_k127_3150445_13 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 386.0
HKD2_k127_3150445_14 Pfam:HipA_N K07154 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 384.0
HKD2_k127_3150445_15 metalloprotease K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 332.0
HKD2_k127_3150445_16 Domain of unknown function (DUF4893) - - - 0.000000000000000000000000000000000000000000000000000001794 198.0
HKD2_k127_3150445_17 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.000000000000000000000000000000000000000000000003493 187.0
HKD2_k127_3150445_18 ETC complex I subunit - - - 0.000000000000000000000000000000007544 129.0
HKD2_k127_3150445_19 - - - - 0.0000000000000000000000007529 108.0
HKD2_k127_3150445_2 of ABC transporters with duplicated ATPase K15738 - - 5.784e-299 925.0
HKD2_k127_3150445_3 protein conserved in bacteria - - - 3.07e-270 844.0
HKD2_k127_3150445_4 Pfam Sulfatase K01130 - 3.1.6.1 7.646e-220 687.0
HKD2_k127_3150445_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 2.165e-219 702.0
HKD2_k127_3150445_6 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 1.69e-216 684.0
HKD2_k127_3150445_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 616.0
HKD2_k127_3150445_8 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009311 578.0
HKD2_k127_3150445_9 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 511.0
HKD2_k127_3185446_0 Thioredoxin K05838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 448.0
HKD2_k127_3185446_1 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 366.0
HKD2_k127_3185446_2 Transcriptional regulator, AbiEi antitoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 329.0
HKD2_k127_3185446_3 to the N-terminal domain of Lon protease K07157 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008412 322.0
HKD2_k127_3185446_4 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 293.0
HKD2_k127_3185446_5 - - - - 0.00000000000000000000000000000000000000000000000000003376 193.0
HKD2_k127_3185446_6 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000001472 154.0
HKD2_k127_3185446_7 - - - - 0.000001948 51.0
HKD2_k127_3207800_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0 1084.0
HKD2_k127_3207800_1 Cytochrome C and Quinol oxidase polypeptide I K04561 - 1.7.2.5 0.0 1072.0
HKD2_k127_3207800_10 Alanine racemase, N-terminal domain K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 546.0
HKD2_k127_3207800_11 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 533.0
HKD2_k127_3207800_12 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006416 478.0
HKD2_k127_3207800_13 dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 450.0
HKD2_k127_3207800_14 D-amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 447.0
HKD2_k127_3207800_15 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 432.0
HKD2_k127_3207800_16 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006427 402.0
HKD2_k127_3207800_17 ribosomal protein L11 K02687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 375.0
HKD2_k127_3207800_18 chemotaxis K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 380.0
HKD2_k127_3207800_19 Dehydrogenase K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 369.0
HKD2_k127_3207800_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0 1050.0
HKD2_k127_3207800_20 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 364.0
HKD2_k127_3207800_21 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 361.0
HKD2_k127_3207800_22 COG0491 Zn-dependent hydrolases, including glyoxylases K17837 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 332.0
HKD2_k127_3207800_23 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005227 305.0
HKD2_k127_3207800_24 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 299.0
HKD2_k127_3207800_25 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002186 283.0
HKD2_k127_3207800_26 short-chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002006 272.0
HKD2_k127_3207800_27 N-terminal domain of ribose phosphate pyrophosphokinase K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000003695 269.0
HKD2_k127_3207800_28 Protein of unknown function (DUF2459) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007917 263.0
HKD2_k127_3207800_29 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002616 261.0
HKD2_k127_3207800_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 3.854e-229 721.0
HKD2_k127_3207800_30 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000002987 240.0
HKD2_k127_3207800_31 Protein of unknown function (DUF1211) - - - 0.0000000000000000000000000000000000000000000000000000000000004263 220.0
HKD2_k127_3207800_32 Acetyltransferase (GNAT) domain K03830 - - 0.00000000000000000000000000000000000000002649 164.0
HKD2_k127_3207800_33 succinate dehydrogenase K00241 - - 0.00000000000000000000000000000000000000003737 155.0
HKD2_k127_3207800_34 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.00000000000000000000000000000000000000008049 156.0
HKD2_k127_3207800_35 RelE-like toxin of type II toxin-antitoxin system HigB - - - 0.0000000000000000000000000000000000009164 142.0
HKD2_k127_3207800_36 Preprotein translocase subunit YajC K03210 - - 0.0000000000000000000000000000000002025 136.0
HKD2_k127_3207800_37 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.000000000000000000000000000000001044 133.0
HKD2_k127_3207800_38 succinate dehydrogenase K00242 - - 0.00000000000000000000000001984 119.0
HKD2_k127_3207800_39 KR domain - - - 0.00000000000000000000000008273 115.0
HKD2_k127_3207800_4 peptidase S10 serine carboxypeptidase - - - 1.939e-224 709.0
HKD2_k127_3207800_40 Domain of unknown function (DUF1993) K09983 - - 0.00000000000000000000007509 104.0
HKD2_k127_3207800_41 ISXO2-like transposase domain - - - 0.0000000000000000000002849 107.0
HKD2_k127_3207800_42 Ketosteroid isomerase-related protein - - - 0.0000000000000000003696 91.0
HKD2_k127_3207800_44 - - - - 0.0000000007025 64.0
HKD2_k127_3207800_5 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 1.266e-221 703.0
HKD2_k127_3207800_6 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.358e-207 655.0
HKD2_k127_3207800_7 May be involved in recombinational repair of damaged DNA K03631 - - 1.061e-206 661.0
HKD2_k127_3207800_8 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 610.0
HKD2_k127_3207800_9 Thymidine phosphorylase K00758 - 2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 567.0
HKD2_k127_3327467_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000001809 234.0
HKD2_k127_3327467_1 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000202 209.0
HKD2_k127_3327467_2 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000002116 156.0
HKD2_k127_3327467_3 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0000000009727 62.0
HKD2_k127_3327467_4 Penicillinase repressor - - - 0.000000002956 64.0
HKD2_k127_3375556_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004392 263.0
HKD2_k127_3375556_1 Acetyltransferase (GNAT) domain K03827 - - 0.0000000000000000000000000000000000007091 147.0
HKD2_k127_3375556_2 transcriptional K05800 - - 0.0000000000000000000000000000000001673 138.0
HKD2_k127_3375556_3 copper resistance protein K07245 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000003635 138.0
HKD2_k127_3375556_4 homoserine dehydrogenase K00003,K12524 - 1.1.1.3,2.7.2.4 0.000000000000000000000001288 104.0
HKD2_k127_3375556_5 Copper resistance protein K07156 - - 0.00000000000000000000002184 104.0
HKD2_k127_3375556_6 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000000000000005081 83.0
HKD2_k127_3375556_7 - - - - 0.00000000112 68.0
HKD2_k127_3401037_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.0 1104.0
HKD2_k127_3401037_1 Heat shock 70 kDa protein K04043 - - 0.0 1091.0
HKD2_k127_3401037_10 PFAM Aminotransferase class I and II K00832 - 2.6.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 526.0
HKD2_k127_3401037_11 Oxidoreductase FAD-binding domain K00523,K02613 - 1.17.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 507.0
HKD2_k127_3401037_12 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 474.0
HKD2_k127_3401037_13 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 438.0
HKD2_k127_3401037_14 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 422.0
HKD2_k127_3401037_15 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 399.0
HKD2_k127_3401037_16 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009764 407.0
HKD2_k127_3401037_17 enoyl-CoA hydratase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 392.0
HKD2_k127_3401037_18 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007219 373.0
HKD2_k127_3401037_19 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 351.0
HKD2_k127_3401037_2 MaoC like domain K02618 - 1.2.1.91,3.3.2.12 0.0 1073.0
HKD2_k127_3401037_20 Binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 317.0
HKD2_k127_3401037_21 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007442 313.0
HKD2_k127_3401037_22 beta' subunit K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 293.0
HKD2_k127_3401037_23 polysaccharide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001193 269.0
HKD2_k127_3401037_24 XRE family transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002148 252.0
HKD2_k127_3401037_25 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000315 218.0
HKD2_k127_3401037_26 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000000000000000000000000000000000009107 199.0
HKD2_k127_3401037_27 DnaJ molecular chaperone homology domain K05516 - - 0.0000000000000000000000000000000000000000000000001229 185.0
HKD2_k127_3401037_28 Phenylacetic acid degradation B K02610 - - 0.0000000000000000000000000000000000000000000000007157 178.0
HKD2_k127_3401037_29 Domain of unknown function (DUF4163) - - - 0.000000000000000000000000000000000000000000001458 175.0
HKD2_k127_3401037_3 Dicarboxylate transport - - - 0.0 1048.0
HKD2_k127_3401037_30 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000000006227 160.0
HKD2_k127_3401037_31 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000000000006683 154.0
HKD2_k127_3401037_32 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000151 149.0
HKD2_k127_3401037_33 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000000000000000002333 141.0
HKD2_k127_3401037_34 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000001564 141.0
HKD2_k127_3401037_35 PFAM OsmC family protein K06889,K07397 - - 0.00000000000000000000000000000000005898 139.0
HKD2_k127_3401037_36 - - - - 0.0000000000000000000000000000000001673 139.0
HKD2_k127_3401037_37 protein conserved in bacteria K09978 - - 0.0000000000000000000000000000001605 130.0
HKD2_k127_3401037_38 Nucleotidyltransferase - - - 0.0000000000000000000000001457 111.0
HKD2_k127_3401037_39 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000000001469 107.0
HKD2_k127_3401037_4 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 3.781e-231 721.0
HKD2_k127_3401037_40 signal transduction histidine kinase - - - 0.0000000000000000000372 100.0
HKD2_k127_3401037_41 Glycosyltransferase family 87 - - - 0.0000000000000000001653 101.0
HKD2_k127_3401037_43 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.0000000000000002087 84.0
HKD2_k127_3401037_5 acyl-CoA dehydrogenase K00249 - 1.3.8.7 3.965e-207 650.0
HKD2_k127_3401037_6 Ring hydroxylating alpha subunit (catalytic domain) - - - 7.638e-200 628.0
HKD2_k127_3401037_7 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 3.868e-194 607.0
HKD2_k127_3401037_8 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 556.0
HKD2_k127_3401037_9 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006833 548.0
HKD2_k127_3434606_0 Glycosyl transferase family 41 - - - 2.902e-196 636.0
HKD2_k127_3434606_1 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 531.0
HKD2_k127_3434606_2 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000002574 178.0
HKD2_k127_3474036_0 receptor K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 560.0
HKD2_k127_3474036_1 - - - - 0.0000000000000000000000000000000000000000000008858 171.0
HKD2_k127_3474036_2 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000115 166.0
HKD2_k127_3474036_3 50S ribosomal protein L31 K02909 - - 0.000000000000000000000000000000000004041 138.0
HKD2_k127_359951_0 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain K03974 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 535.0
HKD2_k127_359951_1 ABC transporter, ATP-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 468.0
HKD2_k127_359951_10 Phage shock protein B K03970 - - 0.00000000000000000000000000001607 119.0
HKD2_k127_359951_11 - - - - 0.0000000000000000000000000001554 120.0
HKD2_k127_359951_12 - - - - 0.00000000000000000004369 92.0
HKD2_k127_359951_14 - - - - 0.0000004302 60.0
HKD2_k127_359951_15 - - - - 0.0006339 46.0
HKD2_k127_359951_2 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 404.0
HKD2_k127_359951_3 Carboxylesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 375.0
HKD2_k127_359951_4 Phage shock protein A K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 309.0
HKD2_k127_359951_5 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 298.0
HKD2_k127_359951_6 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002978 277.0
HKD2_k127_359951_7 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000256 271.0
HKD2_k127_359951_8 SufE protein probably involved in Fe-S center assembly K02426 - - 0.000000000000000000000000000000000000000000000000000000006365 201.0
HKD2_k127_359951_9 PspC domain K03973 - - 0.000000000000000000000000000000000000001745 153.0
HKD2_k127_3660866_0 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005934 529.0
HKD2_k127_3660866_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006179 376.0
HKD2_k127_3660866_2 nodulation K00612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 327.0
HKD2_k127_3660866_3 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000001799 121.0
HKD2_k127_3660866_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000001897 86.0
HKD2_k127_3660866_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0003674,GO:0005215 - 0.00000000000003151 74.0
HKD2_k127_3660866_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0003674,GO:0005215 - 0.0000000000001019 79.0
HKD2_k127_3660866_7 COG3658 Cytochrome b - - - 0.000000007143 62.0
HKD2_k127_3835838_0 Protein export membrane protein - - - 0.0 1655.0
HKD2_k127_3835838_1 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000006009 227.0
HKD2_k127_3836428_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 2.08e-322 1004.0
HKD2_k127_3836428_1 Glycosyl hydrolase family 1 - - - 0.00000000000000000000000000000000000000000002493 166.0
HKD2_k127_3836428_2 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000000000001409 69.0
HKD2_k127_3836428_3 Short-chain dehydrogenase reductase sdr - - - 0.0000003456 54.0
HKD2_k127_3836428_4 transposition K07483,K07497 - - 0.000005166 48.0
HKD2_k127_3849855_0 WD40-like Beta Propeller Repeat - - - 0.0 1191.0
HKD2_k127_3849855_1 NADH:flavin oxidoreductase / NADH oxidase family K00317 - 1.5.8.1,1.5.8.2 0.0 1008.0
HKD2_k127_3849855_10 AraC family transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006359 249.0
HKD2_k127_3849855_11 Major facilitator Superfamily K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000001 248.0
HKD2_k127_3849855_12 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000002666 255.0
HKD2_k127_3849855_13 Outer membrane protein beta-barrel domain - - - 0.0000000000000000000000000000000000000000000000000000002079 209.0
HKD2_k127_3849855_14 - - - - 0.0000000000000000000000000000000000000000000000000000003701 204.0
HKD2_k127_3849855_15 - - - - 0.00000000000000000000000000000000000000000000000000000378 200.0
HKD2_k127_3849855_16 Phage derived protein Gp49-like (DUF891) - - - 0.0000000000000000000000000000000000000000000000000006146 185.0
HKD2_k127_3849855_17 Sulfotransferase domain - - - 0.00000000000000000000000000000000000000000001601 173.0
HKD2_k127_3849855_18 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000002725 165.0
HKD2_k127_3849855_19 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000001874 127.0
HKD2_k127_3849855_2 asparagine synthase K01953 - 6.3.5.4 1.132e-223 710.0
HKD2_k127_3849855_20 long-chain fatty acid transport protein - - - 0.00000000000000000000000000001677 128.0
HKD2_k127_3849855_21 Transcriptional regulator - - - 0.0000000000000000000000000005433 117.0
HKD2_k127_3849855_22 Cache 3/Cache 2 fusion domain K02480 - 2.7.13.3 0.0000000000000000000001151 108.0
HKD2_k127_3849855_23 Domain of unknown function (DUF4880) K07165 - - 0.0000000000000005714 88.0
HKD2_k127_3849855_24 - - - - 0.00000000009454 68.0
HKD2_k127_3849855_25 helix_turn_helix, Lux Regulon - - - 0.0000000002756 68.0
HKD2_k127_3849855_26 - - - - 0.00000004521 61.0
HKD2_k127_3849855_27 Nucleoside-diphosphate-sugar epimerase K07276 - - 0.000000145 54.0
HKD2_k127_3849855_28 P63C domain - - - 0.00006997 49.0
HKD2_k127_3849855_3 Aldehyde dehydrogenase family - - - 7.588e-197 633.0
HKD2_k127_3849855_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 583.0
HKD2_k127_3849855_5 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 385.0
HKD2_k127_3849855_6 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 407.0
HKD2_k127_3849855_7 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 354.0
HKD2_k127_3849855_8 aminopeptidase activity K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000586 353.0
HKD2_k127_3849855_9 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 284.0
HKD2_k127_3853807_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1817.0
HKD2_k127_3853807_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 8.921e-304 944.0
HKD2_k127_3853807_10 - - - - 0.00000000000000000000000000002601 125.0
HKD2_k127_3853807_11 Domain of unknown function (DUF4170) - - - 0.00000000000000000000000000006466 117.0
HKD2_k127_3853807_12 - - - - 0.000000000000000000000000161 115.0
HKD2_k127_3853807_13 Transcriptional regulator - - - 0.00000000000000004579 88.0
HKD2_k127_3853807_14 Transcriptional regulator - - - 0.0000000000000002752 85.0
HKD2_k127_3853807_15 - - - - 0.000000000000937 73.0
HKD2_k127_3853807_16 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000004771 70.0
HKD2_k127_3853807_17 Protein of unknown function (DUF3618) - - - 0.0000000121 64.0
HKD2_k127_3853807_18 - - - - 0.0000000255 57.0
HKD2_k127_3853807_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 2.578e-218 701.0
HKD2_k127_3853807_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 5.572e-217 682.0
HKD2_k127_3853807_4 Belongs to the CarA family K01956 - 6.3.5.5 2.591e-200 630.0
HKD2_k127_3853807_5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004427 250.0
HKD2_k127_3853807_6 membrane protein (homolog of Drosophila rhomboid) - - - 0.0000000000000000000000000000000000000000000000000000000000000000008122 236.0
HKD2_k127_3853807_7 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000000000000000000002307 214.0
HKD2_k127_3853807_8 SpoIIAA-like - - - 0.00000000000000000000000000000000000000000002284 164.0
HKD2_k127_3853807_9 Septum formation initiator - - - 0.0000000000000000000000000000000000129 141.0
HKD2_k127_3854826_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 327.0
HKD2_k127_3854826_1 Response regulator of the LytR AlgR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000009931 242.0
HKD2_k127_3854826_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000289 242.0
HKD2_k127_3854826_3 - - - - 0.00000000000000000001244 98.0
HKD2_k127_3923161_0 TonB dependent receptor - - - 0.0 1041.0
HKD2_k127_3923161_1 Elongation factor G, domain IV K02355 - - 9.904e-290 903.0
HKD2_k127_3923161_10 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 484.0
HKD2_k127_3923161_11 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006979 477.0
HKD2_k127_3923161_12 Major facilitator superfamily K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 469.0
HKD2_k127_3923161_13 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 424.0
HKD2_k127_3923161_14 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 371.0
HKD2_k127_3923161_15 PFAM polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 346.0
HKD2_k127_3923161_16 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 335.0
HKD2_k127_3923161_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008293 321.0
HKD2_k127_3923161_18 Arginase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 323.0
HKD2_k127_3923161_19 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008954 302.0
HKD2_k127_3923161_2 Domain of Unknown Function with PDB structure (DUF3857) - - - 2.711e-282 902.0
HKD2_k127_3923161_20 3-deoxy-manno-octulosonate cytidylyltransferase K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000005431 273.0
HKD2_k127_3923161_21 sugar phosphatases of the HAD superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001699 259.0
HKD2_k127_3923161_22 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005723 249.0
HKD2_k127_3923161_23 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000004482 241.0
HKD2_k127_3923161_24 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000001061 216.0
HKD2_k127_3923161_26 - - - - 0.0000002157 64.0
HKD2_k127_3923161_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 2.613e-268 831.0
HKD2_k127_3923161_4 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 2.703e-197 623.0
HKD2_k127_3923161_5 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 4.698e-197 618.0
HKD2_k127_3923161_6 Alkaline phosphatase with broad substrate specificity K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000736 597.0
HKD2_k127_3923161_7 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 581.0
HKD2_k127_3923161_8 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 552.0
HKD2_k127_3923161_9 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 500.0
HKD2_k127_3966018_2 TRANSCRIPTIONal - - - 0.0004867 48.0
HKD2_k127_3980105_0 UDP-N-acetylmuramate-alanine ligase K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 616.0
HKD2_k127_3980105_1 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006692 597.0
HKD2_k127_3980105_10 - - - - 0.0000000000000000000000000001625 123.0
HKD2_k127_3980105_12 Virulence factor BrkB K07058 - - 0.00000000005293 64.0
HKD2_k127_3980105_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 437.0
HKD2_k127_3980105_3 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 362.0
HKD2_k127_3980105_4 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 341.0
HKD2_k127_3980105_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009878 324.0
HKD2_k127_3980105_6 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001044 242.0
HKD2_k127_3980105_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003683 228.0
HKD2_k127_3980105_8 - - - - 0.0000000000000000000000000000000000000000000000000000002288 207.0
HKD2_k127_3980105_9 - - - - 0.0000000000000000000000000000000000000000531 155.0
HKD2_k127_4022539_0 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 481.0
HKD2_k127_4022539_1 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005633 258.0
HKD2_k127_4022539_2 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000002496 203.0
HKD2_k127_4022539_3 Cupin - - - 0.00000001553 57.0
HKD2_k127_4132778_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1590.0
HKD2_k127_4132778_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.0 997.0
HKD2_k127_4132778_10 Alpha beta hydrolase - - - 0.00000009516 54.0
HKD2_k127_4132778_2 Histidine K01745 - 4.3.1.3 4.766e-225 706.0
HKD2_k127_4132778_3 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 526.0
HKD2_k127_4132778_4 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000003655 209.0
HKD2_k127_4132778_5 SOS response K14160 - - 0.0000000000000000000000000000000000000000000000001824 184.0
HKD2_k127_4132778_6 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000000000000006173 111.0
HKD2_k127_4132778_7 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000001657 102.0
HKD2_k127_4132778_8 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.000000000000000000001492 98.0
HKD2_k127_4132778_9 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000000008656 98.0
HKD2_k127_4354675_0 E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate K00164 - 1.2.4.2 0.0 1528.0
HKD2_k127_4354675_1 5-methyltetrahydrofolate--homocysteine methyltransferase K00548 - 2.1.1.13 0.0 1337.0
HKD2_k127_4354675_10 signal peptide peptidase K04773 - - 1.513e-212 676.0
HKD2_k127_4354675_11 Metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 617.0
HKD2_k127_4354675_12 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 617.0
HKD2_k127_4354675_13 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 610.0
HKD2_k127_4354675_14 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 579.0
HKD2_k127_4354675_15 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 569.0
HKD2_k127_4354675_16 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 560.0
HKD2_k127_4354675_17 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 549.0
HKD2_k127_4354675_18 dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 545.0
HKD2_k127_4354675_19 AFG1 family ATPase K06916 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 524.0
HKD2_k127_4354675_2 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0 1019.0
HKD2_k127_4354675_20 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 518.0
HKD2_k127_4354675_21 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 521.0
HKD2_k127_4354675_22 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 474.0
HKD2_k127_4354675_23 Methionine synthase I (cobalamin-dependent), methyltransferase domain K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 481.0
HKD2_k127_4354675_24 Na -driven multidrug efflux pump K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 470.0
HKD2_k127_4354675_25 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K13584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006816 456.0
HKD2_k127_4354675_26 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 456.0
HKD2_k127_4354675_27 In Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 448.0
HKD2_k127_4354675_28 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 419.0
HKD2_k127_4354675_29 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 415.0
HKD2_k127_4354675_3 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 9.281e-311 957.0
HKD2_k127_4354675_30 beta-N-acetylhexosaminidase K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 419.0
HKD2_k127_4354675_31 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 399.0
HKD2_k127_4354675_32 ArsR family transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007659 392.0
HKD2_k127_4354675_33 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 364.0
HKD2_k127_4354675_34 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 349.0
HKD2_k127_4354675_35 Pseudouridine synthase K06177 - 5.4.99.28,5.4.99.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 315.0
HKD2_k127_4354675_36 cation diffusion facilitator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 312.0
HKD2_k127_4354675_37 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003447 277.0
HKD2_k127_4354675_38 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000141 265.0
HKD2_k127_4354675_39 GAF domain-containing protein K08968 - 1.8.4.14 0.0000000000000000000000000000000000000000000000000000000000000000000001236 243.0
HKD2_k127_4354675_4 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.409e-280 872.0
HKD2_k127_4354675_40 Sporulation related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008157 237.0
HKD2_k127_4354675_41 protein, possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000000000000000000000000000009617 228.0
HKD2_k127_4354675_42 Sporulation related domain - - - 0.00000000000000000000000000000000000000000000000000000000000001201 232.0
HKD2_k127_4354675_43 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000008223 201.0
HKD2_k127_4354675_44 Universal stress protein - - - 0.000000000000000000000000000000000000000000000000001135 186.0
HKD2_k127_4354675_45 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000002249 188.0
HKD2_k127_4354675_46 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000000000000000000004414 179.0
HKD2_k127_4354675_47 chain release factor K15034 - - 0.000000000000000000000000000000000000000002842 159.0
HKD2_k127_4354675_48 Thioesterase superfamily K10806 - - 0.00000000000000000000000000000000000001143 148.0
HKD2_k127_4354675_5 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 4.082e-244 759.0
HKD2_k127_4354675_50 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000000000000000000000000007449 123.0
HKD2_k127_4354675_51 protein secretion K03116 - - 0.0000000000000000000006807 98.0
HKD2_k127_4354675_54 - - - - 0.00005303 47.0
HKD2_k127_4354675_6 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 8.592e-237 739.0
HKD2_k127_4354675_7 Thiol disulfide interchange protein - - - 9.413e-228 722.0
HKD2_k127_4354675_8 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 2.937e-219 687.0
HKD2_k127_4354675_9 peptidase S10 serine carboxypeptidase - - - 5.834e-215 680.0
HKD2_k127_4393299_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 1.848e-241 753.0
HKD2_k127_4393299_1 Luciferase-like monooxygenase K17228 - 1.14.14.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008211 548.0
HKD2_k127_4393299_10 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000000000000000000000000000000000007549 200.0
HKD2_k127_4393299_11 - - - - 0.0000000000000000000000000000000005595 135.0
HKD2_k127_4393299_2 Thioredoxin reductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 437.0
HKD2_k127_4393299_3 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 419.0
HKD2_k127_4393299_4 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006173 407.0
HKD2_k127_4393299_5 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 364.0
HKD2_k127_4393299_6 2-methylthioadenine K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 311.0
HKD2_k127_4393299_7 Predicted integral membrane protein (DUF2189) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001377 276.0
HKD2_k127_4393299_8 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000000000000000000000000000000001544 205.0
HKD2_k127_4393299_9 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000007201 204.0
HKD2_k127_453729_0 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009719 312.0
HKD2_k127_453729_1 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001573 252.0
HKD2_k127_453729_2 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000001109 220.0
HKD2_k127_453729_3 Amidohydrolase family - - - 0.0000000000000000000000006718 109.0
HKD2_k127_4736781_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1373.0
HKD2_k127_4736781_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1372.0
HKD2_k127_4736781_10 ATP-dependent DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.134e-261 814.0
HKD2_k127_4736781_100 membrane K08973 - - 0.0000000000000000000000000000000000000000000000000000000000003788 215.0
HKD2_k127_4736781_101 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000004507 221.0
HKD2_k127_4736781_102 Protein conserved in bacteria K11719 - - 0.0000000000000000000000000000000000000000000000000000000000007908 218.0
HKD2_k127_4736781_103 COG3773 Cell wall hydrolyses involved in spore germination - - - 0.00000000000000000000000000000000000000000000000000000000001619 214.0
HKD2_k127_4736781_104 protein conserved in bacteria K09774 - - 0.00000000000000000000000000000000000000000000000000000000002105 217.0
HKD2_k127_4736781_105 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000000000000001519 204.0
HKD2_k127_4736781_106 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000002276 215.0
HKD2_k127_4736781_107 Protein of unknown function (DUF1345) - - - 0.0000000000000000000000000000000000000000000000000000000003058 212.0
HKD2_k127_4736781_108 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000003101 208.0
HKD2_k127_4736781_109 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000001545 205.0
HKD2_k127_4736781_11 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 4.185e-261 812.0
HKD2_k127_4736781_110 PTS IIA-like nitrogen-regulatory protein PtsN K02806 - - 0.000000000000000000000000000000000000000000000000000000004485 202.0
HKD2_k127_4736781_111 Domain of unknown function (DUF3576) - - - 0.00000000000000000000000000000000000000000000000000000001514 200.0
HKD2_k127_4736781_112 Acyl-CoA hydrolase K10806 - - 0.000000000000000000000000000000000000000000000000000004137 197.0
HKD2_k127_4736781_113 Lipopolysaccharide-assembly K03643 - - 0.00000000000000000000000000000000000000000000000000001748 193.0
HKD2_k127_4736781_114 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.0000000000000000000000000000000000000000000000000000284 202.0
HKD2_k127_4736781_115 Uncharacterized ACR, COG1399 - - - 0.0000000000000000000000000000000000000000000000000002673 192.0
HKD2_k127_4736781_116 Pfam:HipA_N - - - 0.0000000000000000000000000000000000000000000000000005482 191.0
HKD2_k127_4736781_117 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000000001563 192.0
HKD2_k127_4736781_118 membrane - - - 0.000000000000000000000000000000000000000000000000008215 183.0
HKD2_k127_4736781_119 Cell division protein K09811 - - 0.0000000000000000000000000000000000000000000000001313 188.0
HKD2_k127_4736781_12 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.021e-249 773.0
HKD2_k127_4736781_120 Domain of unknown function (DUF4167) - - - 0.0000000000000000000000000000000000000000000000001556 185.0
HKD2_k127_4736781_121 CBS domain - - - 0.000000000000000000000000000000000000000000000008557 175.0
HKD2_k127_4736781_122 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000000000002149 179.0
HKD2_k127_4736781_123 - - - - 0.0000000000000000000000000000000000000000000000239 174.0
HKD2_k127_4736781_124 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.000000000000000000000000000000000000000000000119 178.0
HKD2_k127_4736781_125 Small protein A (tmRNA-binding) - - - 0.0000000000000000000000000000000000000000000006162 170.0
HKD2_k127_4736781_126 zinc-ribbon domain - - - 0.000000000000000000000000000000000000000000003794 175.0
HKD2_k127_4736781_127 response regulator K11443 - - 0.00000000000000000000000000000000000000000007637 167.0
HKD2_k127_4736781_128 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000001959 166.0
HKD2_k127_4736781_129 Small Multidrug Resistance protein K11741 - - 0.000000000000000000000000000000000000000001083 162.0
HKD2_k127_4736781_13 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 8.067e-241 755.0
HKD2_k127_4736781_130 Domain of unknown function (DUF4402) - - - 0.00000000000000000000000000000000000001693 150.0
HKD2_k127_4736781_131 Ankyrin repeat - - - 0.00000000000000000000000000000000000003039 151.0
HKD2_k127_4736781_132 - - - - 0.0000000000000000000000000000000000003493 158.0
HKD2_k127_4736781_133 Metal-dependent hydrolase K07043 - - 0.00000000000000000000000000000000003201 144.0
HKD2_k127_4736781_134 Protein conserved in bacteria - - - 0.00000000000000000000000000000000012 136.0
HKD2_k127_4736781_135 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000000000000000000000000186 134.0
HKD2_k127_4736781_137 Pfam:HipA_N K07154 - 2.7.11.1 0.000000000000000000000000000004316 123.0
HKD2_k127_4736781_138 Ubiquinol-cytochrome C chaperone K17662 - - 0.000000000000000000000000001829 121.0
HKD2_k127_4736781_139 Fe2 transport system protein A K04758 - - 0.000000000000000000000000002242 113.0
HKD2_k127_4736781_14 peptidase U62, modulator of DNA gyrase K03568 - - 4.058e-239 747.0
HKD2_k127_4736781_140 Protein of unknown function (DUF502) - - - 0.000000000000000000000000006441 118.0
HKD2_k127_4736781_141 Beta-Ig-H3 fasciclin - - - 0.00000000000000000000000001113 117.0
HKD2_k127_4736781_142 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000000000000004659 106.0
HKD2_k127_4736781_144 Domain of unknown function (DUF4402) - - - 0.000000000000000000000006484 107.0
HKD2_k127_4736781_146 - - - - 0.00000000000000000000001447 99.0
HKD2_k127_4736781_147 protein conserved in bacteria - - - 0.000000000000000000002144 95.0
HKD2_k127_4736781_148 - - - - 0.000000000000000000003261 97.0
HKD2_k127_4736781_149 - - - - 0.000000000000000000006122 93.0
HKD2_k127_4736781_15 Heparinase - - - 1.196e-229 724.0
HKD2_k127_4736781_150 Protein of unknown function (DUF3572) - - - 0.00000000000000000001342 93.0
HKD2_k127_4736781_152 Domain of unknown function (DUF4402) - - - 0.000000000000000002424 91.0
HKD2_k127_4736781_153 Protein of unknown function (DUF1491) - - - 0.000000000000000004347 93.0
HKD2_k127_4736781_155 - - - - 0.0000000000000004667 81.0
HKD2_k127_4736781_158 - - - - 0.000000000000005078 85.0
HKD2_k127_4736781_159 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.000000000000006501 83.0
HKD2_k127_4736781_16 Isocitrate lyase K01637 - 4.1.3.1 5.262e-222 698.0
HKD2_k127_4736781_160 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.00000000000003396 79.0
HKD2_k127_4736781_161 - - - - 0.0000000000007854 80.0
HKD2_k127_4736781_162 Domain of unknown function (DUF4402) - - - 0.0000000004681 68.0
HKD2_k127_4736781_163 - - - - 0.0000002181 55.0
HKD2_k127_4736781_164 - - - - 0.0000006092 57.0
HKD2_k127_4736781_165 Putative MetA-pathway of phenol degradation - - - 0.000001053 61.0
HKD2_k127_4736781_168 - - - - 0.0002561 53.0
HKD2_k127_4736781_17 Malate synthase K01637,K01638 GO:0003674,GO:0003824,GO:0004451,GO:0004474,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0007275,GO:0007568,GO:0008150,GO:0008152,GO:0008340,GO:0009987,GO:0010259,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032501,GO:0032502,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046487,GO:0046912,GO:0048856,GO:0071704 2.3.3.9,4.1.3.1 3.02e-219 692.0
HKD2_k127_4736781_18 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 5.543e-219 685.0
HKD2_k127_4736781_19 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 1.042e-213 673.0
HKD2_k127_4736781_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1282.0
HKD2_k127_4736781_20 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 9.157e-210 657.0
HKD2_k127_4736781_21 Outer membrane receptor proteins, mostly Fe transport - - - 1.432e-208 685.0
HKD2_k127_4736781_22 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 2.711e-207 647.0
HKD2_k127_4736781_23 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 4.415e-196 619.0
HKD2_k127_4736781_24 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 3.625e-195 619.0
HKD2_k127_4736781_25 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 584.0
HKD2_k127_4736781_26 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 573.0
HKD2_k127_4736781_27 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 583.0
HKD2_k127_4736781_28 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 576.0
HKD2_k127_4736781_29 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007563 573.0
HKD2_k127_4736781_3 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0 1047.0
HKD2_k127_4736781_30 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 547.0
HKD2_k127_4736781_31 peptidase S10 serine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 554.0
HKD2_k127_4736781_32 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 536.0
HKD2_k127_4736781_33 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 532.0
HKD2_k127_4736781_34 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007831 531.0
HKD2_k127_4736781_35 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 534.0
HKD2_k127_4736781_36 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 524.0
HKD2_k127_4736781_37 protein conserved in bacteria K09919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 509.0
HKD2_k127_4736781_38 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 512.0
HKD2_k127_4736781_39 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 527.0
HKD2_k127_4736781_4 DNA segregation ATPase FtsK SpoIIIE K03466 - - 8.545e-301 942.0
HKD2_k127_4736781_40 DEAD DEAH box helicase K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 512.0
HKD2_k127_4736781_41 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 496.0
HKD2_k127_4736781_42 Phage integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 496.0
HKD2_k127_4736781_43 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 484.0
HKD2_k127_4736781_44 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 477.0
HKD2_k127_4736781_45 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 471.0
HKD2_k127_4736781_46 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 460.0
HKD2_k127_4736781_47 (EC 2.1.1.113) (N-4 cytosine-specific methyltransferase K00590 - 2.1.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009244 463.0
HKD2_k127_4736781_48 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 456.0
HKD2_k127_4736781_49 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 456.0
HKD2_k127_4736781_5 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 3.177e-299 932.0
HKD2_k127_4736781_50 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 447.0
HKD2_k127_4736781_51 (EC 2.1.1.113) (N-4 cytosine-specific methyltransferase K00590 - 2.1.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 456.0
HKD2_k127_4736781_52 IrrE N-terminal-like domain K07110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 452.0
HKD2_k127_4736781_53 NADH flavin oxidoreductase NADH oxidase K10680 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 433.0
HKD2_k127_4736781_54 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 424.0
HKD2_k127_4736781_55 beta-lactamase K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 426.0
HKD2_k127_4736781_56 ABC-type (Unclassified) transport system, ATPase component K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 415.0
HKD2_k127_4736781_57 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 408.0
HKD2_k127_4736781_58 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005843 407.0
HKD2_k127_4736781_59 Chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 398.0
HKD2_k127_4736781_6 Sulfatase K01130 - 3.1.6.1 1.205e-279 870.0
HKD2_k127_4736781_60 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 400.0
HKD2_k127_4736781_61 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 368.0
HKD2_k127_4736781_62 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003617 370.0
HKD2_k127_4736781_63 endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 364.0
HKD2_k127_4736781_64 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 367.0
HKD2_k127_4736781_65 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 362.0
HKD2_k127_4736781_66 Cold shock K03704 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 362.0
HKD2_k127_4736781_67 MTH538 TIR-like domain (DUF1863) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 381.0
HKD2_k127_4736781_68 cell division K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 364.0
HKD2_k127_4736781_69 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 357.0
HKD2_k127_4736781_7 Ferrous iron transport protein B K04759 - - 2.527e-279 872.0
HKD2_k127_4736781_70 Thioredoxin K05838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 360.0
HKD2_k127_4736781_71 Asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 352.0
HKD2_k127_4736781_72 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 343.0
HKD2_k127_4736781_73 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 353.0
HKD2_k127_4736781_74 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 336.0
HKD2_k127_4736781_75 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 340.0
HKD2_k127_4736781_76 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009828 333.0
HKD2_k127_4736781_77 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006535 327.0
HKD2_k127_4736781_78 Carbohydrate-selective porin, OprB family K07267 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 327.0
HKD2_k127_4736781_79 COG3121 P pilus assembly protein, chaperone PapD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 313.0
HKD2_k127_4736781_8 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 3.051e-279 865.0
HKD2_k127_4736781_80 Riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 306.0
HKD2_k127_4736781_81 membrane protein, TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009837 288.0
HKD2_k127_4736781_82 DNA polymerase III K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003686 290.0
HKD2_k127_4736781_83 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001263 265.0
HKD2_k127_4736781_84 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002583 261.0
HKD2_k127_4736781_85 RpsU-divergently transcribed K18587 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003103 261.0
HKD2_k127_4736781_86 DNA mediated transformation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003314 275.0
HKD2_k127_4736781_87 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003529 257.0
HKD2_k127_4736781_88 membrane protein, TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003789 259.0
HKD2_k127_4736781_89 to the N-terminal domain of Lon protease K07157 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002722 255.0
HKD2_k127_4736781_9 usher protein - - - 7.364e-266 846.0
HKD2_k127_4736781_90 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000001441 252.0
HKD2_k127_4736781_91 Belongs to the UPF0260 family K09160 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006888 238.0
HKD2_k127_4736781_92 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.000000000000000000000000000000000000000000000000000000000000000001043 232.0
HKD2_k127_4736781_93 endoribonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000002066 238.0
HKD2_k127_4736781_94 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000000002543 231.0
HKD2_k127_4736781_95 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000000000000000000000000000000000000000000000000000000000000000008121 230.0
HKD2_k127_4736781_96 DNA repair protein MmcB-like - - - 0.0000000000000000000000000000000000000000000000000000000000000001431 224.0
HKD2_k127_4736781_97 EamA-like transporter family K15270 - - 0.000000000000000000000000000000000000000000000000000000000000001364 233.0
HKD2_k127_4736781_98 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000000000000009958 225.0
HKD2_k127_4736781_99 - - - - 0.0000000000000000000000000000000000000000000000000000000000002514 219.0
HKD2_k127_4778890_0 Transposase DDE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008693 586.0
HKD2_k127_4778890_1 Phage integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 362.0
HKD2_k127_4778890_2 Integrase core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 299.0
HKD2_k127_4778890_3 DNA excision - - - 0.000000000000001137 81.0
HKD2_k127_4915731_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 536.0
HKD2_k127_4915731_1 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006419 509.0
HKD2_k127_4915731_2 Amidinotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002734 276.0
HKD2_k127_4915731_3 Major facilitator superfamily K03446 - - 0.00000000000000000000000000000000000000000000000009345 181.0
HKD2_k127_4915731_4 Belongs to the UPF0235 family K09131 - - 0.0000000006075 69.0
HKD2_k127_5027270_0 protein related to capsule biosynthesis enzymes K07154 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007663 278.0
HKD2_k127_5027270_1 Flavodoxin-like fold K00355 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000005158 270.0
HKD2_k127_5027270_10 LysE type translocator - - - 0.000000000000000000000000001033 124.0
HKD2_k127_5027270_2 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001083 261.0
HKD2_k127_5027270_3 Alcohol dehydrogenase GroES-like domain K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000705 241.0
HKD2_k127_5027270_4 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000001956 222.0
HKD2_k127_5027270_5 rhodanese-related sulfurtransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000703 215.0
HKD2_k127_5027270_6 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000001258 209.0
HKD2_k127_5027270_7 LysR substrate binding domain K03566 - - 0.000000000000000000000000000000000000000000000000000002915 200.0
HKD2_k127_5027270_8 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000001972 172.0
HKD2_k127_5027270_9 Helix-turn-helix domain - - - 0.000000000000000000000000000004869 122.0
HKD2_k127_5061325_0 of ABC transporters with duplicated ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008662 556.0
HKD2_k127_5061325_1 Transcription elongation factor, GreA/GreB, C-term K06140 - - 0.00000000000000000000000000000000000006955 146.0
HKD2_k127_5061325_2 Acid phosphatase homologues - - - 0.0000000000000000002524 93.0
HKD2_k127_5061325_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000008157 86.0
HKD2_k127_5061325_4 - - - - 0.000001062 55.0
HKD2_k127_5061325_5 - - - - 0.0002769 49.0
HKD2_k127_5061325_6 LysR substrate binding domain - - - 0.0008731 44.0
HKD2_k127_5169895_0 Diguanylate cyclase - - - 4.401e-198 634.0
HKD2_k127_5169895_1 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002487 233.0
HKD2_k127_5171720_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 6.93e-251 787.0
HKD2_k127_5171720_1 rod shape-determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 605.0
HKD2_k127_5171720_10 Sporulation related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 307.0
HKD2_k127_5171720_11 FOG TPR repeat, SEL1 subfamily K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000211 256.0
HKD2_k127_5171720_12 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000001194 226.0
HKD2_k127_5171720_13 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000000000000000000000000000000000001881 224.0
HKD2_k127_5171720_14 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000000000006983 186.0
HKD2_k127_5171720_15 - - - - 0.0000000000000000000000000000000000000000000000001097 185.0
HKD2_k127_5171720_16 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000001208 153.0
HKD2_k127_5171720_17 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000000000000001715 145.0
HKD2_k127_5171720_18 membrane - - - 0.0000000000000000000000000000000000008687 143.0
HKD2_k127_5171720_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 592.0
HKD2_k127_5171720_3 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 415.0
HKD2_k127_5171720_4 Protein of unknown function (DUF3089) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003278 405.0
HKD2_k127_5171720_5 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 392.0
HKD2_k127_5171720_6 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 365.0
HKD2_k127_5171720_7 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 319.0
HKD2_k127_5171720_8 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 306.0
HKD2_k127_5171720_9 phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 308.0
HKD2_k127_5181918_0 His Kinase A (phosphoacceptor) domain - - - 0.0 2231.0
HKD2_k127_5181918_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.0 1002.0
HKD2_k127_5181918_10 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 408.0
HKD2_k127_5181918_11 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 405.0
HKD2_k127_5181918_12 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 394.0
HKD2_k127_5181918_13 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 392.0
HKD2_k127_5181918_14 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 372.0
HKD2_k127_5181918_15 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 299.0
HKD2_k127_5181918_16 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008895 263.0
HKD2_k127_5181918_17 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001578 250.0
HKD2_k127_5181918_18 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000000000000000001267 237.0
HKD2_k127_5181918_19 Serine/threonine phosphatases, family 2C, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000001274 226.0
HKD2_k127_5181918_2 Histidine kinase - - - 6.921e-257 809.0
HKD2_k127_5181918_20 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000000000000000000000000000000002344 219.0
HKD2_k127_5181918_21 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.000000000000000000000000000000000000000000000000000000000003734 218.0
HKD2_k127_5181918_22 peptidyl-prolyl cis-trans isomerase K03767 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000001242 204.0
HKD2_k127_5181918_23 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000002318 207.0
HKD2_k127_5181918_24 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000001086 182.0
HKD2_k127_5181918_25 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000002417 179.0
HKD2_k127_5181918_26 SURF1-like protein K14998 - - 0.0000000000000000000000000000000000000001321 157.0
HKD2_k127_5181918_27 Protein of unknown function (DUF983) - - - 0.00000000000000000000000000000000000004044 150.0
HKD2_k127_5181918_28 - - - - 0.0000000000000000000000000000000005465 132.0
HKD2_k127_5181918_29 DNA mediated transformation - - - 0.0000000000000000000000000000000174 137.0
HKD2_k127_5181918_3 His Kinase A (phosphoacceptor) domain - - - 2.938e-249 773.0
HKD2_k127_5181918_31 Peptidyl-prolyl cis-trans K03772 - 5.2.1.8 0.0000000000000000000000000000005043 128.0
HKD2_k127_5181918_32 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000009203 113.0
HKD2_k127_5181918_33 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.000000000000000000002793 99.0
HKD2_k127_5181918_34 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000000002181 63.0
HKD2_k127_5181918_4 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 567.0
HKD2_k127_5181918_5 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 475.0
HKD2_k127_5181918_6 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 449.0
HKD2_k127_5181918_7 protein conserved in bacteria K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 458.0
HKD2_k127_5181918_8 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007576 420.0
HKD2_k127_5181918_9 PFAM peptidase M16 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 421.0
HKD2_k127_5184055_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.0 1148.0
HKD2_k127_5184055_1 Required for chromosome condensation and partitioning K03529 - - 0.0 1090.0
HKD2_k127_5184055_10 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 393.0
HKD2_k127_5184055_11 glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 396.0
HKD2_k127_5184055_12 beta-lactamase K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 327.0
HKD2_k127_5184055_13 Belongs to the Nudix hydrolase family K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 316.0
HKD2_k127_5184055_14 Membrane-associated sensor, integral membrane domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003984 325.0
HKD2_k127_5184055_15 Protein of unknown function (DUF3667) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 312.0
HKD2_k127_5184055_16 amine dehydrogenase activity K17285 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 304.0
HKD2_k127_5184055_17 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 289.0
HKD2_k127_5184055_18 OmpW family K07275 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008818 289.0
HKD2_k127_5184055_19 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004054 281.0
HKD2_k127_5184055_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1078.0
HKD2_k127_5184055_20 cytochrome C K08738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000225 274.0
HKD2_k127_5184055_21 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000001546 271.0
HKD2_k127_5184055_22 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007359 274.0
HKD2_k127_5184055_23 Domain of unknown function (DUF4115) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001866 253.0
HKD2_k127_5184055_24 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001181 243.0
HKD2_k127_5184055_25 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003363 248.0
HKD2_k127_5184055_26 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000139 243.0
HKD2_k127_5184055_27 FMN_bind - - - 0.000000000000000000000000000000000000000000000000000000000000000000055 237.0
HKD2_k127_5184055_28 Protein of unknown function (DUF721) - - - 0.00000000000000000000000000000000000000000000000000000000000002282 220.0
HKD2_k127_5184055_29 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000000000000000000000001109 214.0
HKD2_k127_5184055_3 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 8.239e-314 972.0
HKD2_k127_5184055_30 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000128 209.0
HKD2_k127_5184055_31 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000000000000000000004495 187.0
HKD2_k127_5184055_32 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000003143 193.0
HKD2_k127_5184055_33 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000003422 191.0
HKD2_k127_5184055_34 Membrane-bound metallopeptidase - - - 0.0000000000000000000000000000000000000000000000009615 189.0
HKD2_k127_5184055_35 Disulfide bond formation protein - - - 0.00000000000000000000000000000000000000000000005759 174.0
HKD2_k127_5184055_36 to be involved in C-type cytochrome biogenesis - - - 0.00000000000000000000000000000000000000004173 160.0
HKD2_k127_5184055_37 Histidine kinase - - - 0.00000000000000000000000000000000000001781 158.0
HKD2_k127_5184055_38 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000005284 138.0
HKD2_k127_5184055_39 Integrase core domain - - - 0.000000000000000000000000000000000007491 140.0
HKD2_k127_5184055_4 DNA-binding protein with the helix-hairpin-helix motif - - - 3.111e-210 659.0
HKD2_k127_5184055_40 Staphylococcal nuclease homologue - - - 0.00000000000000000000000000000000004857 136.0
HKD2_k127_5184055_42 - - - - 0.0000000000000000000000000002056 120.0
HKD2_k127_5184055_43 - - - - 0.000000000000000000000000000343 119.0
HKD2_k127_5184055_44 fatty acid desaturase K00508 - 1.14.19.3 0.00000000000000000000000003252 113.0
HKD2_k127_5184055_45 Ribonuclease B OB domain K03704 - - 0.00000000000000000000003164 104.0
HKD2_k127_5184055_46 Staphylococcal nuclease homologue - - - 0.000000000000007866 78.0
HKD2_k127_5184055_47 Fatty acid desaturase K00508 - 1.14.19.3 0.00000000007249 67.0
HKD2_k127_5184055_48 - - - - 0.000000001796 62.0
HKD2_k127_5184055_5 Belongs to the peptidase S41A family K03797 - 3.4.21.102 5.9e-209 661.0
HKD2_k127_5184055_50 - - - - 0.000000989 55.0
HKD2_k127_5184055_6 Uracil-DNA glycosylase K21929 - 3.2.2.27 1.206e-194 617.0
HKD2_k127_5184055_7 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 464.0
HKD2_k127_5184055_8 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 433.0
HKD2_k127_5184055_9 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 393.0
HKD2_k127_5224244_0 Voltage gated chloride channel K03281 - - 5.663e-208 657.0
HKD2_k127_5224244_1 Outer membrane efflux protein K18300,K19593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 567.0
HKD2_k127_5224244_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 565.0
HKD2_k127_5224244_3 Caspase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001675 278.0
HKD2_k127_5224244_4 helix_turn_helix, Lux Regulon K14987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009845 252.0
HKD2_k127_5226878_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1272.0
HKD2_k127_5226878_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 4.163e-209 669.0
HKD2_k127_5226878_2 peptidase M20 K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007955 526.0
HKD2_k127_5226878_3 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 394.0
HKD2_k127_5226878_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 315.0
HKD2_k127_5226878_5 - - - - 0.00000000000000000000000000000000000000000000000000002147 199.0
HKD2_k127_5226878_6 - - - - 0.0000000000000000000000000000003025 129.0
HKD2_k127_5226878_7 COG1403 Restriction endonuclease - - - 0.0000000002106 68.0
HKD2_k127_5226878_8 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.00003359 51.0
HKD2_k127_5230799_0 Autotransporter beta-domain - - - 8.61e-257 827.0
HKD2_k127_5230799_1 Aerobic cobaltochelatase subunit CobS K09882 - 6.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 607.0
HKD2_k127_5230799_10 molecular chaperone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001031 243.0
HKD2_k127_5230799_11 Glutathione S-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000008933 231.0
HKD2_k127_5230799_12 Lactoylglutathione lyase K07032 - - 0.0000000000000000000000000000000000000000000000000000000002294 206.0
HKD2_k127_5230799_13 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000416 183.0
HKD2_k127_5230799_14 Belongs to the BolA IbaG family K05527 - - 0.000000000000000000000000000000006887 131.0
HKD2_k127_5230799_2 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 443.0
HKD2_k127_5230799_3 COG2931 RTX toxins and related Ca2 -binding proteins K01406 - 3.4.24.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 443.0
HKD2_k127_5230799_4 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 300.0
HKD2_k127_5230799_5 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005316 281.0
HKD2_k127_5230799_6 PFAM 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001433 276.0
HKD2_k127_5230799_7 Protein of unknown function (DUF1428) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001761 278.0
HKD2_k127_5230799_8 enzyme related to lactoylglutathione lyase K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001112 279.0
HKD2_k127_5230799_9 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001234 259.0
HKD2_k127_5286156_0 GTP cyclohydrolase K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 359.0
HKD2_k127_5286156_1 FAD-NAD(P)-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 360.0
HKD2_k127_5286156_2 Domain of unknown function (DUF2383) - - - 0.000000000000000000000000000000000000000003265 158.0
HKD2_k127_5331816_0 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 0.0 1207.0
HKD2_k127_5331816_1 Belongs to the ClpA ClpB family K03694 - - 0.0 1204.0
HKD2_k127_5331816_10 Belongs to the DEAD box helicase family - - - 5.272e-194 614.0
HKD2_k127_5331816_11 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 6.163e-194 613.0
HKD2_k127_5331816_12 Peptidase M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 574.0
HKD2_k127_5331816_13 Belongs to the glycosyl hydrolase 43 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 571.0
HKD2_k127_5331816_14 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 537.0
HKD2_k127_5331816_15 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006279 519.0
HKD2_k127_5331816_16 Natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008832 522.0
HKD2_k127_5331816_17 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 507.0
HKD2_k127_5331816_18 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 481.0
HKD2_k127_5331816_19 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 466.0
HKD2_k127_5331816_2 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 1.023e-317 995.0
HKD2_k127_5331816_20 NADPH quinone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 459.0
HKD2_k127_5331816_21 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 452.0
HKD2_k127_5331816_22 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 447.0
HKD2_k127_5331816_23 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 446.0
HKD2_k127_5331816_24 nitrogen fixation sensor protein fixL K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 439.0
HKD2_k127_5331816_25 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 436.0
HKD2_k127_5331816_26 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 408.0
HKD2_k127_5331816_27 PFAM SapC family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 377.0
HKD2_k127_5331816_28 protein conserved in bacteria K09987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007551 368.0
HKD2_k127_5331816_29 COG1538 Outer membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 381.0
HKD2_k127_5331816_3 Cytochrome C and Quinol oxidase polypeptide I K02298 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.10.3.10 3.231e-315 976.0
HKD2_k127_5331816_30 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 357.0
HKD2_k127_5331816_31 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 362.0
HKD2_k127_5331816_32 Cytochrome C oxidase subunit II, periplasmic domain K02297 - 1.10.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 344.0
HKD2_k127_5331816_33 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 339.0
HKD2_k127_5331816_34 Protein phosphatase 2A homologues, catalytic domain. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005433 340.0
HKD2_k127_5331816_35 dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 318.0
HKD2_k127_5331816_36 Belongs to the MIP aquaporin (TC 1.A.8) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009908 312.0
HKD2_k127_5331816_37 Belongs to the BI1 family K06890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 308.0
HKD2_k127_5331816_38 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003059 279.0
HKD2_k127_5331816_39 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004926 277.0
HKD2_k127_5331816_4 GTP-binding protein TypA K06207 - - 1.887e-309 957.0
HKD2_k127_5331816_40 part of global network that controls expression of aerobic respiratory terminal oxidases and carbon and nitrogen metabolic enzymes K14987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003119 270.0
HKD2_k127_5331816_41 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003704 273.0
HKD2_k127_5331816_42 oxidase subunit K02299 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001653 261.0
HKD2_k127_5331816_43 Protein-disulfide isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003826 266.0
HKD2_k127_5331816_44 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000004873 252.0
HKD2_k127_5331816_45 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005518 261.0
HKD2_k127_5331816_46 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000006548 246.0
HKD2_k127_5331816_47 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000004013 240.0
HKD2_k127_5331816_48 Cation efflux family - - - 0.000000000000000000000000000000000000000000000000000000000000000000009941 244.0
HKD2_k127_5331816_49 HlyD family secretion protein K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000001482 239.0
HKD2_k127_5331816_5 Prolyl oligopeptidase family - - - 1.435e-291 910.0
HKD2_k127_5331816_50 Protein involved in meta-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000000000000000000000000003422 237.0
HKD2_k127_5331816_51 response regulator K13589 - - 0.00000000000000000000000000000000000000000000000000000000000000008239 224.0
HKD2_k127_5331816_52 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001303 227.0
HKD2_k127_5331816_53 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.00000000000000000000000000000000000000000000000000000000000003604 220.0
HKD2_k127_5331816_54 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000006908 217.0
HKD2_k127_5331816_55 EVE domain - - - 0.000000000000000000000000000000000000000000000000000004632 193.0
HKD2_k127_5331816_56 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000001716 190.0
HKD2_k127_5331816_57 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000966 191.0
HKD2_k127_5331816_58 COG3773 Cell wall hydrolyses involved in spore germination K01449 - 3.5.1.28 0.00000000000000000000000000000000000000000007058 170.0
HKD2_k127_5331816_59 Prokaryotic Cytochrome C oxidase subunit IV K02300 - - 0.000000000000000000000000000000000001012 149.0
HKD2_k127_5331816_6 Peptidase, M28 - - - 4.828e-233 733.0
HKD2_k127_5331816_60 - - - - 0.00000000000000000000000000000000002103 139.0
HKD2_k127_5331816_61 - - - - 0.00000000000000000000000000000002268 132.0
HKD2_k127_5331816_62 Pfam:Pyridox_oxidase - - - 0.00000000000000000000000000000005328 132.0
HKD2_k127_5331816_63 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000000000000001267 113.0
HKD2_k127_5331816_64 Plasmid stabilization - - - 0.00000000000000000003606 92.0
HKD2_k127_5331816_65 - - - - 0.00000000000008347 80.0
HKD2_k127_5331816_66 Protein of unknown function (DUF3828) - - - 0.0000000000004182 77.0
HKD2_k127_5331816_67 - - - - 0.000000000004664 71.0
HKD2_k127_5331816_68 Protein of unknown function (DUF1192) - - - 0.000000000006789 70.0
HKD2_k127_5331816_69 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.0000001103 57.0
HKD2_k127_5331816_7 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 2.88e-230 722.0
HKD2_k127_5331816_70 helix_turn_helix multiple antibiotic resistance protein - - - 0.000005984 53.0
HKD2_k127_5331816_8 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 7.728e-219 688.0
HKD2_k127_5331816_9 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 1.258e-206 646.0
HKD2_k127_5361652_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008776 585.0
HKD2_k127_5361652_1 Protein of unknown function (DUF2975) - - - 0.0000000000000000000000000000000000001042 149.0
HKD2_k127_5402028_0 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006102 529.0
HKD2_k127_5402028_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 469.0
HKD2_k127_5402028_10 Transcriptional K22042 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000004171 114.0
HKD2_k127_5402028_11 Putative phosphatase (DUF442) K17218 - 1.8.5.4 0.00000000000000000000000001021 122.0
HKD2_k127_5402028_12 Cold-shock protein K03704 - - 0.0000000000000000000000006131 107.0
HKD2_k127_5402028_13 - - - - 0.00000000003777 68.0
HKD2_k127_5402028_14 - - - - 0.0008175 45.0
HKD2_k127_5402028_2 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 380.0
HKD2_k127_5402028_3 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 346.0
HKD2_k127_5402028_4 Major Facilitator Superfamily K08169 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 347.0
HKD2_k127_5402028_5 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003413 271.0
HKD2_k127_5402028_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000002304 219.0
HKD2_k127_5402028_7 fatty acid desaturase K00508 - 1.14.19.3 0.0000000000000000000000000000000000000000000000000001652 200.0
HKD2_k127_5402028_8 transporter component K07112 - - 0.000000000000000000000000000000000000000003579 166.0
HKD2_k127_5402028_9 Sulphur transport K07112 - - 0.0000000000000000000000000000000000003655 146.0
HKD2_k127_5475965_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1516.0
HKD2_k127_5475965_1 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0 1207.0
HKD2_k127_5475965_10 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.012e-201 638.0
HKD2_k127_5475965_11 Belongs to the thiolase family - - - 1.775e-198 628.0
HKD2_k127_5475965_12 mandelate racemase muconate lactonizing K01684,K01781,K08323 - 4.2.1.6,4.2.1.8,5.1.2.2 2.127e-198 623.0
HKD2_k127_5475965_13 epoxide hydrolase K01253,K21159 - 3.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 617.0
HKD2_k127_5475965_14 phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 550.0
HKD2_k127_5475965_15 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006008 544.0
HKD2_k127_5475965_16 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 497.0
HKD2_k127_5475965_17 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 494.0
HKD2_k127_5475965_18 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 482.0
HKD2_k127_5475965_19 ABC transporter, ATP-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 468.0
HKD2_k127_5475965_2 COG1505 Serine proteases of the peptidase family S9A K01322 - 3.4.21.26 0.0 1058.0
HKD2_k127_5475965_20 Response regulator of the LytR AlgR family K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 457.0
HKD2_k127_5475965_21 Domain of unknown function (DUF4118) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009584 456.0
HKD2_k127_5475965_22 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 458.0
HKD2_k127_5475965_23 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 442.0
HKD2_k127_5475965_24 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 424.0
HKD2_k127_5475965_25 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 420.0
HKD2_k127_5475965_26 phosphate-selective porin K07221 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006429 422.0
HKD2_k127_5475965_27 Castor and Pollux, part of voltage-gated ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009729 406.0
HKD2_k127_5475965_28 Galactose 1-dehydrogenase K00035 - 1.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 402.0
HKD2_k127_5475965_29 Carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 391.0
HKD2_k127_5475965_3 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1051.0
HKD2_k127_5475965_30 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 404.0
HKD2_k127_5475965_31 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 376.0
HKD2_k127_5475965_32 Aminomethyltransferase K06980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 369.0
HKD2_k127_5475965_33 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 368.0
HKD2_k127_5475965_34 Binding-protein-dependent transport system inner membrane component K02038 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 365.0
HKD2_k127_5475965_35 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005725 360.0
HKD2_k127_5475965_36 Gluconolactonase K14274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007666 356.0
HKD2_k127_5475965_37 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 348.0
HKD2_k127_5475965_38 ABC-type Na efflux pump, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 347.0
HKD2_k127_5475965_39 protein conserved in bacteria K09781 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 336.0
HKD2_k127_5475965_4 Transport of potassium into the cell - - - 8.385e-303 939.0
HKD2_k127_5475965_40 Histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 329.0
HKD2_k127_5475965_41 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 312.0
HKD2_k127_5475965_42 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006279 302.0
HKD2_k127_5475965_43 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 301.0
HKD2_k127_5475965_44 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 295.0
HKD2_k127_5475965_45 protein involved in formation of curli polymers - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 296.0
HKD2_k127_5475965_46 COG2513 PEP phosphonomutase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000447 279.0
HKD2_k127_5475965_47 COG2513 PEP phosphonomutase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001114 276.0
HKD2_k127_5475965_48 Aldolase K01631 - 4.1.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000003305 266.0
HKD2_k127_5475965_49 Phenylalanine-4-hydroxylase K00500 - 1.14.16.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002701 267.0
HKD2_k127_5475965_5 Histidine kinase - - - 3.005e-268 850.0
HKD2_k127_5475965_50 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003867 264.0
HKD2_k127_5475965_51 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001699 269.0
HKD2_k127_5475965_52 protein conserved in bacteria K09985 - - 0.0000000000000000000000000000000000000000000000000000000000000000003278 232.0
HKD2_k127_5475965_53 protein conserved in bacteria K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000007071 234.0
HKD2_k127_5475965_54 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000005574 226.0
HKD2_k127_5475965_55 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000006986 223.0
HKD2_k127_5475965_56 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000008044 229.0
HKD2_k127_5475965_57 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.0000000000000000000000000000000000000000000000000000000000000001336 228.0
HKD2_k127_5475965_58 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000004334 240.0
HKD2_k127_5475965_59 periplasmic protein - - - 0.000000000000000000000000000000000000000000000000000000000000002077 227.0
HKD2_k127_5475965_6 amino acid K03294 - - 5.491e-262 816.0
HKD2_k127_5475965_60 Iron-sulfur cluster assembly protein K02612 - - 0.00000000000000000000000000000000000000000000000000000000004242 210.0
HKD2_k127_5475965_61 Lipid A 3-O-deacylase (PagL) - - - 0.00000000000000000000000000000000000000000000000000000000043 206.0
HKD2_k127_5475965_62 UPF0314 protein - - - 0.00000000000000000000000000000000000000000000000000000004009 204.0
HKD2_k127_5475965_63 GAF domain - - - 0.0000000000000000000000000000000000000000000000002718 186.0
HKD2_k127_5475965_64 helix_turn_helix, Lux Regulon K07685 - - 0.000000000000000000000000000000000000000000002823 172.0
HKD2_k127_5475965_65 Protein of unknown function (DUF1272) K09984 - - 0.00000000000000000000000000000000000000000006194 161.0
HKD2_k127_5475965_66 Putative esterase K07017 - - 0.0000000000000000000000000000000000000000002322 170.0
HKD2_k127_5475965_67 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000001002 115.0
HKD2_k127_5475965_68 Response regulator receiver - - - 0.000000000000000000000002566 107.0
HKD2_k127_5475965_69 - - - - 0.000000000000000000001319 98.0
HKD2_k127_5475965_7 Glycosyl hydrolase family 1 - - - 6.547e-232 724.0
HKD2_k127_5475965_70 - - - - 0.0000000000000000005438 91.0
HKD2_k127_5475965_71 Alpha beta hydrolase - - - 0.00000000000003759 74.0
HKD2_k127_5475965_72 - - - - 0.0000000000009146 78.0
HKD2_k127_5475965_74 - - - - 0.0006157 48.0
HKD2_k127_5475965_8 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 5.305e-210 660.0
HKD2_k127_5475965_9 GvpD gas vesicle protein K08482 - - 8.575e-205 649.0
HKD2_k127_5479237_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 409.0
HKD2_k127_5479237_1 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000217 212.0
HKD2_k127_5479237_2 PP-loop superfamily ATPase - - - 0.000000000000000000000000000000001019 136.0
HKD2_k127_5479237_3 biosynthesis protein E K06139 - - 0.000000000000000000005875 96.0
HKD2_k127_56066_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 477.0
HKD2_k127_56066_1 Protein of unknown function (DUF3485) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 416.0
HKD2_k127_56066_2 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 290.0
HKD2_k127_56066_3 polysaccharide deactylase family protein - - - 0.00000000000000000000000000000000000000000000002637 171.0
HKD2_k127_5617525_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1210.0
HKD2_k127_5617525_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1181.0
HKD2_k127_5617525_10 acyl-CoA dehydrogenase K00249 - 1.3.8.7 6.037e-216 673.0
HKD2_k127_5617525_11 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 2.34e-215 680.0
HKD2_k127_5617525_12 TonB-dependent receptor plug - - - 3.774e-205 666.0
HKD2_k127_5617525_13 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 2.079e-201 634.0
HKD2_k127_5617525_14 Beta-lactamase - - - 5.241e-201 646.0
HKD2_k127_5617525_15 Uncharacterized ACR, YdiU/UPF0061 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 608.0
HKD2_k127_5617525_16 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 587.0
HKD2_k127_5617525_17 POT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009858 567.0
HKD2_k127_5617525_18 Peptidase, M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 568.0
HKD2_k127_5617525_19 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689 554.0
HKD2_k127_5617525_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0 1054.0
HKD2_k127_5617525_20 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 522.0
HKD2_k127_5617525_21 Phosphate starvation-inducible protein PhoH K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 511.0
HKD2_k127_5617525_22 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000937 504.0
HKD2_k127_5617525_23 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 498.0
HKD2_k127_5617525_24 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 486.0
HKD2_k127_5617525_25 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 480.0
HKD2_k127_5617525_26 glucose sorbosone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 456.0
HKD2_k127_5617525_27 enoyl-CoA hydratase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007782 450.0
HKD2_k127_5617525_28 Chalcone and stilbene synthases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 445.0
HKD2_k127_5617525_29 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 445.0
HKD2_k127_5617525_3 MacB-like periplasmic core domain K02004 - - 5.268e-320 999.0
HKD2_k127_5617525_30 Domain of unknown function (DUF389) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 444.0
HKD2_k127_5617525_31 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 430.0
HKD2_k127_5617525_32 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 426.0
HKD2_k127_5617525_33 Putative peptidoglycan binding domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 425.0
HKD2_k127_5617525_34 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 411.0
HKD2_k127_5617525_35 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 391.0
HKD2_k127_5617525_36 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003929 380.0
HKD2_k127_5617525_37 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009125 393.0
HKD2_k127_5617525_38 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 374.0
HKD2_k127_5617525_39 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 366.0
HKD2_k127_5617525_4 MacB-like periplasmic core domain K02004 - - 1.349e-315 987.0
HKD2_k127_5617525_40 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 370.0
HKD2_k127_5617525_41 Cro/C1-type HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 331.0
HKD2_k127_5617525_42 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 336.0
HKD2_k127_5617525_43 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004981 321.0
HKD2_k127_5617525_44 Beta-lactamase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 313.0
HKD2_k127_5617525_45 glutathione transferase activity K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006272 289.0
HKD2_k127_5617525_46 COG0694 Thioredoxin-like proteins and domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 284.0
HKD2_k127_5617525_47 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005247 252.0
HKD2_k127_5617525_48 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001418 243.0
HKD2_k127_5617525_49 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007732 239.0
HKD2_k127_5617525_5 Methylmalonate-semialdehyde dehydrogenase K00140 - 1.2.1.18,1.2.1.27 6.506e-294 906.0
HKD2_k127_5617525_50 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002703 242.0
HKD2_k127_5617525_51 Nucleic-acid-binding protein K07742 - - 0.00000000000000000000000000000000000000000000000000000000000000000006797 239.0
HKD2_k127_5617525_52 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000000000000000000000000002738 235.0
HKD2_k127_5617525_53 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000004483 235.0
HKD2_k127_5617525_54 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00000000000000000000000000000000000000000000000000000000000006401 215.0
HKD2_k127_5617525_55 dioxygenase of extradiol dioxygenase family K06991 - - 0.0000000000000000000000000000000000000000000000000000000000001691 215.0
HKD2_k127_5617525_56 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000003398 216.0
HKD2_k127_5617525_57 Acetyltransferase (GNAT) domain K22479 - - 0.00000000000000000000000000000000000000000000000000000000001345 216.0
HKD2_k127_5617525_58 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000000000000000000000000000006201 208.0
HKD2_k127_5617525_59 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000000000000000000000000414 207.0
HKD2_k127_5617525_6 Participates in both transcription termination and antitermination K02600 - - 4.618e-280 867.0
HKD2_k127_5617525_60 Glutathione S-transferase, C-terminal domain K00799 GO:0000302,GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0016740,GO:0016765,GO:0042221,GO:0042493,GO:0042542,GO:0044424,GO:0044464,GO:0046677,GO:0050896,GO:1901700 2.5.1.18 0.0000000000000000000000000000000000000000000000000000001389 201.0
HKD2_k127_5617525_61 Isoprenylcysteine carboxyl methyltransferase K16168 - - 0.0000000000000000000000000000000000000000000000000002324 193.0
HKD2_k127_5617525_62 Cupin domain - - - 0.0000000000000000000000000000000000000000000000002421 180.0
HKD2_k127_5617525_63 peptidase M22 - - - 0.0000000000000000000000000000000000000000000000002924 184.0
HKD2_k127_5617525_64 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.00000000000000000000000000000000000000000000001805 187.0
HKD2_k127_5617525_65 Acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000003469 180.0
HKD2_k127_5617525_66 SCO1/SenC K07152 - - 0.000000000000000000000000000000000000000000001323 173.0
HKD2_k127_5617525_67 PFAM DoxX family protein K15977 - - 0.0000000000000000000000000000000000000000001054 163.0
HKD2_k127_5617525_68 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000000000002141 153.0
HKD2_k127_5617525_69 Transcriptional - - - 0.00000000000000000000000000000000000004072 146.0
HKD2_k127_5617525_7 Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate K06447 - 1.2.1.71 7.422e-241 752.0
HKD2_k127_5617525_70 Acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000004824 155.0
HKD2_k127_5617525_71 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000000000000000000002146 139.0
HKD2_k127_5617525_72 Domain of unknown function (DUF4136) - - - 0.0000000000000000000000000000136 124.0
HKD2_k127_5617525_73 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.0000000000000000000000000005844 116.0
HKD2_k127_5617525_74 PIN domain - - - 0.0000000000000000000000000006562 119.0
HKD2_k127_5617525_75 Motility quorum-sensing regulator, toxin of MqsA K13651 - - 0.0000000000000000000000005878 104.0
HKD2_k127_5617525_76 Cytochrome C' - - - 0.000000000000000000000001344 111.0
HKD2_k127_5617525_77 - - - - 0.000000000000000000000003687 109.0
HKD2_k127_5617525_78 - - - - 0.0000000000000000000002996 99.0
HKD2_k127_5617525_79 - - - - 0.00000000000000000002873 95.0
HKD2_k127_5617525_8 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 9.314e-222 692.0
HKD2_k127_5617525_80 Antitoxin component of bacterial toxin-antitoxin system, MqsA - - - 0.00000000000000000006187 91.0
HKD2_k127_5617525_81 Antitoxin component of bacterial toxin-antitoxin system, MqsA K13655 - - 0.000000000000000002529 88.0
HKD2_k127_5617525_82 PIN domain - - - 0.0000000000000000104 83.0
HKD2_k127_5617525_83 PFAM Integrase core domain - - - 0.00000000000000001172 82.0
HKD2_k127_5617525_84 - - - - 0.00000000000000278 81.0
HKD2_k127_5617525_85 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K21563 - - 0.000000000000009091 84.0
HKD2_k127_5617525_86 positive regulation of growth - - - 0.00000003729 57.0
HKD2_k127_5617525_9 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 6.358e-217 684.0
HKD2_k127_5745577_0 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 486.0
HKD2_k127_5745577_1 ATP dependent DNA ligase C terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 454.0
HKD2_k127_5745577_10 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.00000004314 55.0
HKD2_k127_5745577_11 - - - - 0.00001719 46.0
HKD2_k127_5745577_12 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00005465 50.0
HKD2_k127_5745577_2 imidazolonepropionase activity K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006618 423.0
HKD2_k127_5745577_3 chemotaxis K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 415.0
HKD2_k127_5745577_4 Arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009808 383.0
HKD2_k127_5745577_5 Alkylated DNA repair protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001757 229.0
HKD2_k127_5745577_6 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.00000000000000000000000000000000000001233 152.0
HKD2_k127_5745577_7 Filamentation induced by cAMP protein fic - - - 0.00000000000000000000000000002467 120.0
HKD2_k127_5745577_8 - - - - 0.00000000000004175 73.0
HKD2_k127_5745577_9 Bacteriophage replication gene A protein (GPA) - - - 0.0000000001234 66.0
HKD2_k127_5753705_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1423.0
HKD2_k127_5753705_1 ABC transporter - - - 0.0 1024.0
HKD2_k127_5753705_10 DNA repair photolyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 580.0
HKD2_k127_5753705_11 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 574.0
HKD2_k127_5753705_12 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 580.0
HKD2_k127_5753705_13 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009026 531.0
HKD2_k127_5753705_14 overlaps another CDS with the same product name K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 456.0
HKD2_k127_5753705_15 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 445.0
HKD2_k127_5753705_16 Alpha Beta K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004592 419.0
HKD2_k127_5753705_17 overlaps another CDS with the same product name K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 428.0
HKD2_k127_5753705_18 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 403.0
HKD2_k127_5753705_19 Major Facilitator K03762 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007394 402.0
HKD2_k127_5753705_2 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 3.484e-288 891.0
HKD2_k127_5753705_20 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 405.0
HKD2_k127_5753705_21 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 304.0
HKD2_k127_5753705_22 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007119 316.0
HKD2_k127_5753705_23 of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 297.0
HKD2_k127_5753705_24 aspartate racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 287.0
HKD2_k127_5753705_25 Sulfotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008805 269.0
HKD2_k127_5753705_26 Protein required for attachment to host cells - - - 0.00000000000000000000000000000000000000000000000000000000006488 207.0
HKD2_k127_5753705_27 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000000000000000297 197.0
HKD2_k127_5753705_28 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000002186 199.0
HKD2_k127_5753705_29 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000004512 198.0
HKD2_k127_5753705_3 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 3.916e-230 719.0
HKD2_k127_5753705_30 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000007391 179.0
HKD2_k127_5753705_31 EF hand - - - 0.000000000000000000000000000000000000000002972 165.0
HKD2_k127_5753705_32 Ferredoxin K04755 - - 0.0000000000000000000000000000000000000001785 152.0
HKD2_k127_5753705_33 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000000001811 153.0
HKD2_k127_5753705_34 EF hand - - - 0.000000000000000000000000000000000001425 147.0
HKD2_k127_5753705_35 MAPEG family - - - 0.000000000000000000000000000000000001691 144.0
HKD2_k127_5753705_36 Domain of unknown function (DUF4142) K08995 - - 0.000000000000000000000000003706 121.0
HKD2_k127_5753705_37 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000792 115.0
HKD2_k127_5753705_38 ergosterol biosynthetic process K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000007415 109.0
HKD2_k127_5753705_39 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000001332 93.0
HKD2_k127_5753705_4 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 2.59e-227 715.0
HKD2_k127_5753705_40 Domain of unknown function (DUF1905) - - - 0.000000000000000001585 92.0
HKD2_k127_5753705_42 Septum formation initiator - - - 0.00000000002368 63.0
HKD2_k127_5753705_5 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K20034 - 6.2.1.44 2.279e-225 711.0
HKD2_k127_5753705_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 7.961e-223 703.0
HKD2_k127_5753705_7 Peptidase, M28 - - - 1.762e-214 674.0
HKD2_k127_5753705_8 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 2.382e-208 656.0
HKD2_k127_5753705_9 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 2.636e-197 619.0
HKD2_k127_5877932_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005246 495.0
HKD2_k127_5877932_1 Belongs to the UPF0262 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008938 285.0
HKD2_k127_5877932_2 Glycosyl hydrolases family 25 K07273 - - 0.000000000000000000000000000000002448 131.0
HKD2_k127_5921091_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1771.0
HKD2_k127_5921091_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1300.0
HKD2_k127_5921091_10 Belongs to the MurCDEF family K01924 - 6.3.2.8 5.573e-235 735.0
HKD2_k127_5921091_101 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.000007811 56.0
HKD2_k127_5921091_11 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 1.536e-226 708.0
HKD2_k127_5921091_12 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 9.588e-225 701.0
HKD2_k127_5921091_13 Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine K01761 - 4.4.1.11 2.042e-218 687.0
HKD2_k127_5921091_14 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 1.491e-213 674.0
HKD2_k127_5921091_15 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 1.474e-195 620.0
HKD2_k127_5921091_16 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 605.0
HKD2_k127_5921091_17 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 602.0
HKD2_k127_5921091_18 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 599.0
HKD2_k127_5921091_19 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008814 572.0
HKD2_k127_5921091_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1200.0
HKD2_k127_5921091_20 Pyrrolo-quinoline quinone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 556.0
HKD2_k127_5921091_21 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 540.0
HKD2_k127_5921091_22 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 539.0
HKD2_k127_5921091_23 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005991 534.0
HKD2_k127_5921091_24 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 533.0
HKD2_k127_5921091_25 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008718 522.0
HKD2_k127_5921091_26 Cell wall formation K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 512.0
HKD2_k127_5921091_27 aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 524.0
HKD2_k127_5921091_28 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 500.0
HKD2_k127_5921091_29 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 479.0
HKD2_k127_5921091_3 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.374e-304 938.0
HKD2_k127_5921091_30 exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 469.0
HKD2_k127_5921091_31 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 470.0
HKD2_k127_5921091_32 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 475.0
HKD2_k127_5921091_33 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009287 465.0
HKD2_k127_5921091_34 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 467.0
HKD2_k127_5921091_35 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 465.0
HKD2_k127_5921091_36 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009997 457.0
HKD2_k127_5921091_37 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 448.0
HKD2_k127_5921091_38 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 433.0
HKD2_k127_5921091_39 Acetoacetyl-CoA reductase K00023 - 1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009785 422.0
HKD2_k127_5921091_4 poly(R)-hydroxyalkanoic acid synthase K03821 - - 1.046e-274 855.0
HKD2_k127_5921091_40 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 436.0
HKD2_k127_5921091_41 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008121 419.0
HKD2_k127_5921091_42 molecular chaperone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 415.0
HKD2_k127_5921091_43 Putative S-adenosyl-L-methionine-dependent methyltransferase K18164 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 398.0
HKD2_k127_5921091_44 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 396.0
HKD2_k127_5921091_45 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 388.0
HKD2_k127_5921091_46 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 381.0
HKD2_k127_5921091_47 RarD protein K05786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 354.0
HKD2_k127_5921091_48 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 345.0
HKD2_k127_5921091_49 Cell division protein FtsQ K03589 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 343.0
HKD2_k127_5921091_5 Protein of unknown function (DUF3604) - - - 8.191e-272 852.0
HKD2_k127_5921091_50 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 334.0
HKD2_k127_5921091_51 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 329.0
HKD2_k127_5921091_52 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 312.0
HKD2_k127_5921091_53 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 312.0
HKD2_k127_5921091_54 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 296.0
HKD2_k127_5921091_55 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 307.0
HKD2_k127_5921091_56 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 292.0
HKD2_k127_5921091_57 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 288.0
HKD2_k127_5921091_58 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 289.0
HKD2_k127_5921091_59 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005744 268.0
HKD2_k127_5921091_6 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 3.295e-256 799.0
HKD2_k127_5921091_60 Domain of unknown function (DUF4893) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001766 269.0
HKD2_k127_5921091_61 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000009581 254.0
HKD2_k127_5921091_62 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009125 251.0
HKD2_k127_5921091_63 Hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000002914 255.0
HKD2_k127_5921091_64 Xre family transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001889 252.0
HKD2_k127_5921091_65 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002503 245.0
HKD2_k127_5921091_66 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000000000000000000000000000000000000001748 238.0
HKD2_k127_5921091_67 Hpt domain K20976 - - 0.00000000000000000000000000000000000000000000000000000000000000007305 226.0
HKD2_k127_5921091_68 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000000000000000000003868 200.0
HKD2_k127_5921091_69 Protein of unknown function (DUF560) - - - 0.00000000000000000000000000000000000000000000000000000002849 213.0
HKD2_k127_5921091_7 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 2.481e-251 785.0
HKD2_k127_5921091_70 Tetratricopeptide repeat-like domain - - - 0.000000000000000000000000000000000000000000000000000000183 201.0
HKD2_k127_5921091_71 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000008542 190.0
HKD2_k127_5921091_72 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000009356 192.0
HKD2_k127_5921091_73 Nudix hydrolase - - - 0.000000000000000000000000000000000000000000000000006355 191.0
HKD2_k127_5921091_74 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000003823 182.0
HKD2_k127_5921091_75 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000007693 185.0
HKD2_k127_5921091_76 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000000000000000000000000008709 180.0
HKD2_k127_5921091_77 Protein of unknown function (DUF1153) - - - 0.000000000000000000000000000000000000000000000001265 175.0
HKD2_k127_5921091_78 Belongs to the HesB IscA family - - - 0.000000000000000000000000000000000000000000003428 168.0
HKD2_k127_5921091_79 - - - - 0.000000000000000000000000000000000000000000007352 171.0
HKD2_k127_5921091_8 Cell division protein FtsI penicillin-binding protein K03587 - 3.4.16.4 4.349e-244 767.0
HKD2_k127_5921091_80 - - - - 0.000000000000000000000000000000000002315 144.0
HKD2_k127_5921091_81 Phasin protein - - - 0.00000000000000000000000000000000005667 147.0
HKD2_k127_5921091_82 - - - - 0.0000000000000000000000000000000005757 142.0
HKD2_k127_5921091_83 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000001868 137.0
HKD2_k127_5921091_84 Transglycosylase associated protein - - - 0.00000000000000000000000000000005035 127.0
HKD2_k127_5921091_85 lactoylglutathione lyase activity K00941,K01724,K01759,K07032,K08234 - 2.7.1.49,2.7.4.7,4.2.1.96,4.4.1.5 0.0000000000000000000000000000001543 129.0
HKD2_k127_5921091_86 alpha, beta K06889 - - 0.00000000000000000000000000114 120.0
HKD2_k127_5921091_87 Transglycosylase associated protein - - - 0.00000000000000000000000001162 115.0
HKD2_k127_5921091_88 -acetyltransferase K03826,K03827,K18816 - 2.3.1.82 0.00000000000000000000000002904 113.0
HKD2_k127_5921091_89 protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis - - - 0.000000000000000000000005144 104.0
HKD2_k127_5921091_9 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 5.444e-237 737.0
HKD2_k127_5921091_90 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000000001528 99.0
HKD2_k127_5921091_91 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K22441 - 2.3.1.57 0.000000000000000000001696 106.0
HKD2_k127_5921091_92 Protein of unknown function (DUF4239) - - - 0.000000000000000000001933 104.0
HKD2_k127_5921091_94 - - - - 0.00000000000000000007853 93.0
HKD2_k127_5921091_95 - - - - 0.000000000000000104 91.0
HKD2_k127_5921091_96 BFD-like [2Fe-2S] binding domain K02192 - - 0.000000000008126 69.0
HKD2_k127_5921091_97 COG2826 Transposase and inactivated derivatives, IS30 family K07482 - - 0.0000001097 53.0
HKD2_k127_5921091_98 - - - - 0.0000001228 61.0
HKD2_k127_604892_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1337.0
HKD2_k127_604892_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 999.0
HKD2_k127_604892_10 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 5.593e-254 791.0
HKD2_k127_604892_100 - - - - 0.000003338 58.0
HKD2_k127_604892_11 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 8.234e-249 771.0
HKD2_k127_604892_12 metallo-beta-lactamase K12574 - - 8.898e-246 769.0
HKD2_k127_604892_13 Belongs to the citrate synthase family K01647 - 2.3.3.1 4.572e-244 757.0
HKD2_k127_604892_14 Protein conserved in bacteria - - - 3.714e-235 741.0
HKD2_k127_604892_15 NADH ubiquinone oxidoreductase subunit K00342 - 1.6.5.3 2.417e-231 728.0
HKD2_k127_604892_16 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 6.315e-217 682.0
HKD2_k127_604892_17 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 1.876e-212 679.0
HKD2_k127_604892_18 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 4.034e-209 655.0
HKD2_k127_604892_19 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 1.146e-202 641.0
HKD2_k127_604892_2 peptidase M13 K07386 - - 7.969e-305 948.0
HKD2_k127_604892_20 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 4.297e-201 646.0
HKD2_k127_604892_21 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 5.531e-201 629.0
HKD2_k127_604892_22 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 1.969e-195 627.0
HKD2_k127_604892_23 Histidine kinase K14980 - 2.7.13.3 1.124e-194 622.0
HKD2_k127_604892_24 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 625.0
HKD2_k127_604892_25 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 596.0
HKD2_k127_604892_26 peptidylprolyl isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 576.0
HKD2_k127_604892_27 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 538.0
HKD2_k127_604892_28 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 516.0
HKD2_k127_604892_29 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 511.0
HKD2_k127_604892_3 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.461e-300 925.0
HKD2_k127_604892_30 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 481.0
HKD2_k127_604892_31 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008971 485.0
HKD2_k127_604892_32 DNA recombination protein K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 481.0
HKD2_k127_604892_33 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 475.0
HKD2_k127_604892_34 PFAM alpha beta hydrolase fold K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 468.0
HKD2_k127_604892_35 PFAM major facilitator superfamily MFS_1 K08169 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 475.0
HKD2_k127_604892_36 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 469.0
HKD2_k127_604892_37 Belongs to the Orn Lys Arg decarboxylase class-II family K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007306 435.0
HKD2_k127_604892_38 peptidylprolyl isomerase K01802,K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 446.0
HKD2_k127_604892_39 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006674 407.0
HKD2_k127_604892_4 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 3.504e-298 920.0
HKD2_k127_604892_40 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005158 396.0
HKD2_k127_604892_41 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 394.0
HKD2_k127_604892_42 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 388.0
HKD2_k127_604892_43 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 395.0
HKD2_k127_604892_44 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006416 389.0
HKD2_k127_604892_45 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 386.0
HKD2_k127_604892_46 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 389.0
HKD2_k127_604892_47 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 378.0
HKD2_k127_604892_48 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 376.0
HKD2_k127_604892_49 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K14981 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 364.0
HKD2_k127_604892_5 Transport of potassium into the cell K03549 - - 1.372e-296 922.0
HKD2_k127_604892_50 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007746 346.0
HKD2_k127_604892_51 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 350.0
HKD2_k127_604892_52 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 329.0
HKD2_k127_604892_53 cyclic nucleotide binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 307.0
HKD2_k127_604892_54 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007421 316.0
HKD2_k127_604892_55 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 301.0
HKD2_k127_604892_56 ATPase involved in DNA replication - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002008 290.0
HKD2_k127_604892_57 Peptidase family S41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008201 292.0
HKD2_k127_604892_58 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002406 279.0
HKD2_k127_604892_59 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000001124 266.0
HKD2_k127_604892_6 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 2.154e-286 897.0
HKD2_k127_604892_60 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004161 248.0
HKD2_k127_604892_61 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000000005915 248.0
HKD2_k127_604892_62 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000002359 250.0
HKD2_k127_604892_63 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006907 247.0
HKD2_k127_604892_64 COG1073 hydrolases of the alpha beta superfamily K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000003716 234.0
HKD2_k127_604892_65 PTS fructose transporter subunit IIA K02793 - 2.7.1.191 0.000000000000000000000000000000000000000000000000000000000000004014 220.0
HKD2_k127_604892_66 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000233 215.0
HKD2_k127_604892_67 DNA polymerase III K02339 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000003573 205.0
HKD2_k127_604892_68 - - - - 0.000000000000000000000000000000000000000000000000000000001809 208.0
HKD2_k127_604892_69 2'-5' RNA ligase superfamily - - - 0.00000000000000000000000000000000000000000000000000000008125 203.0
HKD2_k127_604892_7 Histidine kinase K13587 - 2.7.13.3 1.344e-267 845.0
HKD2_k127_604892_70 Protein of unknown function (DUF3775) - - - 0.000000000000000000000000000000000000000000000000000001566 194.0
HKD2_k127_604892_71 Alkyl hydroperoxide reductase K02199 - - 0.000000000000000000000000000000000000000000000000000003617 195.0
HKD2_k127_604892_72 Serine kinase of the HPr protein, regulates carbohydrate metabolism - - - 0.000000000000000000000000000000000000000000000000000008253 194.0
HKD2_k127_604892_73 PRC-barrel domain - - - 0.00000000000000000000000000000000000000000000000000003532 196.0
HKD2_k127_604892_74 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000000268 188.0
HKD2_k127_604892_75 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000000000086 186.0
HKD2_k127_604892_76 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000005453 183.0
HKD2_k127_604892_77 Dopa 4,5-dioxygenase family K10253 - - 0.000000000000000000000000000000000000000000000003032 176.0
HKD2_k127_604892_78 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000009573 182.0
HKD2_k127_604892_79 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000000000000001093 170.0
HKD2_k127_604892_8 cytochrome C K02198 - - 1.165e-260 817.0
HKD2_k127_604892_80 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000000000139 172.0
HKD2_k127_604892_81 Histidine triad (HIT) protein - - - 0.0000000000000000000000000000000000000000000005397 170.0
HKD2_k127_604892_82 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate - - - 0.0000000000000000000000000000000000000000000152 164.0
HKD2_k127_604892_83 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000003401 157.0
HKD2_k127_604892_84 Domain of unknown function (DUF4136) - - - 0.00000000000000000000000000000000000000007145 159.0
HKD2_k127_604892_85 Cytochrome c biogenesis factor K02200 - - 0.00000000000000000000000000000000000001247 156.0
HKD2_k127_604892_86 NADH ubiquinone oxidoreductase subunit K00341 - 1.6.5.3 0.00000000000000000000000000000000000001258 145.0
HKD2_k127_604892_87 Type IV pilus biogenesis stability protein PilW - - - 0.0000000000000000000000000000000000003524 147.0
HKD2_k127_604892_88 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.00000000000000000000000000000000000434 147.0
HKD2_k127_604892_89 protein conserved in bacteria K09928 - - 0.00000000000000000000000000000000005295 142.0
HKD2_k127_604892_9 protein conserved in bacteria - - - 5.268e-255 806.0
HKD2_k127_604892_90 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000006974 136.0
HKD2_k127_604892_91 META domain - - - 0.0000000000000000000000000000000002777 136.0
HKD2_k127_604892_92 - - - - 0.00000000000000000000000000000002969 136.0
HKD2_k127_604892_93 NIPSNAP - - - 0.0000000000000000000000000000001185 126.0
HKD2_k127_604892_94 COG1925 Phosphotransferase system, HPr-related proteins K11189 - - 0.000000000000000000000000000004233 123.0
HKD2_k127_604892_95 Protein of unknown function (DUF1467) - - - 0.000000000000000000000000000005283 121.0
HKD2_k127_604892_96 Preprotein translocase subunit SecG K03075 - - 0.0000000000000000000000000009205 117.0
HKD2_k127_6253610_0 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) K09883 - 6.6.1.2 7.16e-274 853.0
HKD2_k127_6253610_1 COG1253 Hemolysins and related proteins containing CBS domains K03699 - - 4.092e-203 640.0
HKD2_k127_6253610_10 Uncharacterized protein conserved in bacteria (DUF2093) - - - 0.000000000000000000000002551 103.0
HKD2_k127_6253610_13 COG2931 RTX toxins and related Ca2 -binding proteins K01406 - 3.4.24.40 0.000000000000001917 81.0
HKD2_k127_6253610_14 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000005845 66.0
HKD2_k127_6253610_2 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 601.0
HKD2_k127_6253610_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 601.0
HKD2_k127_6253610_4 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000002432 225.0
HKD2_k127_6253610_5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.000000000000000000000000000000000000000000000000000000000000001078 221.0
HKD2_k127_6253610_6 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000000000000000000000000000000006033 168.0
HKD2_k127_6253610_7 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000001896 160.0
HKD2_k127_6253610_8 NADH ubiquinone oxidoreductase 41 kD complex I subunit - - - 0.000000000000000000000000000000003417 135.0
HKD2_k127_6253610_9 - - - - 0.00000000000000000000000000000002985 132.0
HKD2_k127_6413617_0 COG2801 Transposase and inactivated derivatives K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 402.0
HKD2_k127_6413617_1 Transposase - - - 0.0000000000000000000000000000000000000000000000002321 179.0
HKD2_k127_6413617_2 PFAM transposase IS3 IS911 family protein K07483 - - 0.00000000000000000000000000000001463 132.0
HKD2_k127_6413617_3 IS66 Orf2 K07484 - - 0.000000000004622 69.0
HKD2_k127_6462295_0 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 419.0
HKD2_k127_6462295_1 Autoinducer binding domain K19731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002412 278.0
HKD2_k127_6462295_2 Acyl-homoserine-lactone synthase K18096 - 2.3.1.228,2.3.1.229 0.0000000000000000000000000000000000000000000000000000000000000000003537 236.0
HKD2_k127_6462295_3 Bacterial regulatory proteins, gntR family - - - 0.0000000000000000000000000000000000000001737 156.0
HKD2_k127_6462295_4 Transglutaminase-like superfamily - - - 0.0000000000000000000000118 109.0
HKD2_k127_6462295_5 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000006253 93.0
HKD2_k127_6462295_6 Bacterial regulatory proteins, luxR family - - - 0.00000000005155 66.0
HKD2_k127_6463612_0 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 4.609e-218 688.0
HKD2_k127_6463612_1 Glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005781 548.0
HKD2_k127_6463612_10 - - - - 0.00009787 45.0
HKD2_k127_6463612_2 Conserved TM helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 524.0
HKD2_k127_6463612_3 copper resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006347 517.0
HKD2_k127_6463612_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 422.0
HKD2_k127_6463612_5 Glutaredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 352.0
HKD2_k127_6463612_6 transcriptional - - - 0.00000000000000000000000000000000000000000000000000000002234 203.0
HKD2_k127_6463612_7 Uracil-DNA glycosylase superfamily - - - 0.000000000000000000000000000000000000000000001251 169.0
HKD2_k127_6463612_9 YjbR - - - 0.00000000000000000000000000000004442 128.0
HKD2_k127_6468136_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1250.0
HKD2_k127_6468136_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 4.846e-232 721.0
HKD2_k127_6468136_10 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000000000973 208.0
HKD2_k127_6468136_11 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000000000000001007 177.0
HKD2_k127_6468136_13 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000000002476 143.0
HKD2_k127_6468136_14 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000000005354 102.0
HKD2_k127_6468136_15 large ribosomal subunit rRNA binding - - - 0.0000001962 52.0
HKD2_k127_6468136_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 518.0
HKD2_k127_6468136_3 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 442.0
HKD2_k127_6468136_4 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 377.0
HKD2_k127_6468136_5 Forms part of the polypeptide exit tunnel K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 347.0
HKD2_k127_6468136_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 287.0
HKD2_k127_6468136_7 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002867 271.0
HKD2_k127_6468136_8 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000082 253.0
HKD2_k127_6468136_9 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000000000000005735 222.0
HKD2_k127_6471135_0 Flp pilus assembly protein, ATPase CpaF K02283 - - 9.321e-269 834.0
HKD2_k127_6471135_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007471 514.0
HKD2_k127_6471135_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 468.0
HKD2_k127_6471135_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 - - 0.000000000000000000000000000001557 124.0
HKD2_k127_6471135_4 - - - - 0.000000000000000000000007832 113.0
HKD2_k127_6471135_5 - - - - 0.000000000001243 70.0
HKD2_k127_6551499_0 nitrate reductase, gamma subunit K00374 - 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008489 409.0
HKD2_k127_6551499_1 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 379.0
HKD2_k127_6551499_2 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 309.0
HKD2_k127_6551499_3 Nitrate reductase beta subunit K00371 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005241 268.0
HKD2_k127_6551499_4 Nitrate reductase delta subunit K00373 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005301 263.0
HKD2_k127_6551499_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000922 247.0
HKD2_k127_6551499_6 Cold shock protein domain K03704 - - 0.00000000000000000000000000000000000000000005894 165.0
HKD2_k127_6551499_7 - - - - 0.0000000000001088 74.0
HKD2_k127_6551499_8 - - - - 0.00004389 46.0
HKD2_k127_6627667_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1527.0
HKD2_k127_6627667_1 Peptidase, M16 - - - 0.0 1127.0
HKD2_k127_6627667_10 asparaginase K01424,K13051 - 3.4.19.5,3.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 333.0
HKD2_k127_6627667_11 Castor and Pollux, part of voltage-gated ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 321.0
HKD2_k127_6627667_12 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000001651 254.0
HKD2_k127_6627667_13 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000001515 207.0
HKD2_k127_6627667_14 gag-polyprotein putative aspartyl protease K06985 - - 0.000000000000000000000012 107.0
HKD2_k127_6627667_15 - - - - 0.00000000000000004175 84.0
HKD2_k127_6627667_17 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000001089 78.0
HKD2_k127_6627667_19 - - - - 0.0000000000001079 78.0
HKD2_k127_6627667_2 Histidine kinase - - - 6.534e-234 752.0
HKD2_k127_6627667_20 - - - - 0.000000000003694 73.0
HKD2_k127_6627667_21 YMGG-like Gly-zipper - - - 0.0000000001283 66.0
HKD2_k127_6627667_22 - - - - 0.0004873 46.0
HKD2_k127_6627667_3 Carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 577.0
HKD2_k127_6627667_4 outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 576.0
HKD2_k127_6627667_5 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004991 520.0
HKD2_k127_6627667_6 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 463.0
HKD2_k127_6627667_7 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000521 457.0
HKD2_k127_6627667_8 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 356.0
HKD2_k127_6627667_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009712 351.0
HKD2_k127_6781253_0 Amino-transferase class IV K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 461.0
HKD2_k127_6781253_1 Branched-chain amino acid aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 305.0
HKD2_k127_6781253_2 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000001574 198.0
HKD2_k127_6781253_3 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000001547 166.0
HKD2_k127_6781253_4 Protein of unknown function (DUF3140) - - - 0.000000000000000000000000000000000000003498 150.0
HKD2_k127_6781253_5 Short repeat of unknown function (DUF308) - - - 0.000000009016 66.0
HKD2_k127_6826463_0 RNA polymerase sigma K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 529.0
HKD2_k127_6826463_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 484.0
HKD2_k127_6826463_2 Histidine phosphotransferase C-terminal domain K13588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 293.0
HKD2_k127_6826463_3 Elongation factor G, domain IV K02355 - - 0.000000000000000000000000000000000000000000000000000003518 193.0
HKD2_k127_6930297_0 Transposase - - - 4.664e-268 833.0
HKD2_k127_6930297_1 Plasmid pRiA4b ORF-3-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 305.0
HKD2_k127_6930297_2 Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3' - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 299.0
HKD2_k127_6930297_3 IS66 Orf2 like protein K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000699 228.0
HKD2_k127_6930297_4 Transposase K07483 - - 0.000000000000000000000000000000007588 131.0
HKD2_k127_6930297_5 Transposase - - - 0.000000000000000000000000000156 115.0
HKD2_k127_7386290_0 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004616 430.0
HKD2_k127_7386290_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001959 251.0
HKD2_k127_7386290_2 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000275 91.0
HKD2_k127_7386290_3 - - - - 0.0000000003981 65.0
HKD2_k127_7386290_4 Adenylate cyclase - - - 0.000000002785 61.0
HKD2_k127_7682088_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1183.0
HKD2_k127_7682088_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1098.0
HKD2_k127_7682088_10 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.058e-197 624.0
HKD2_k127_7682088_11 GGDEF domain - - - 6.098e-197 629.0
HKD2_k127_7682088_12 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 3.338e-196 622.0
HKD2_k127_7682088_13 Belongs to the GPI family K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 618.0
HKD2_k127_7682088_14 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 598.0
HKD2_k127_7682088_15 Toxic anion resistance - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 592.0
HKD2_k127_7682088_16 Sugar (and other) transporter K03762 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 588.0
HKD2_k127_7682088_17 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 569.0
HKD2_k127_7682088_18 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 564.0
HKD2_k127_7682088_19 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004595 528.0
HKD2_k127_7682088_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1e-323 997.0
HKD2_k127_7682088_20 Bacterial sugar transferase K21303 - 2.7.8.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 501.0
HKD2_k127_7682088_21 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 478.0
HKD2_k127_7682088_22 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000357 477.0
HKD2_k127_7682088_23 amino acid transport K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 484.0
HKD2_k127_7682088_24 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 471.0
HKD2_k127_7682088_25 III protein, CoA-transferase family K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006324 466.0
HKD2_k127_7682088_26 Polynucleotide adenylyltransferase K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 462.0
HKD2_k127_7682088_27 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 449.0
HKD2_k127_7682088_28 Glycosyltransferase Family 4 K14335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 439.0
HKD2_k127_7682088_29 Metal binding domain of Ada K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 434.0
HKD2_k127_7682088_3 TonB dependent receptor - - - 1.263e-309 973.0
HKD2_k127_7682088_30 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 417.0
HKD2_k127_7682088_31 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 410.0
HKD2_k127_7682088_32 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006939 408.0
HKD2_k127_7682088_33 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 393.0
HKD2_k127_7682088_34 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 391.0
HKD2_k127_7682088_35 Belongs to the 'phage' integrase family K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007653 376.0
HKD2_k127_7682088_36 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 374.0
HKD2_k127_7682088_37 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008248 368.0
HKD2_k127_7682088_38 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 363.0
HKD2_k127_7682088_39 MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 367.0
HKD2_k127_7682088_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.568e-291 899.0
HKD2_k127_7682088_40 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 373.0
HKD2_k127_7682088_41 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 340.0
HKD2_k127_7682088_42 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 337.0
HKD2_k127_7682088_43 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 331.0
HKD2_k127_7682088_44 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 304.0
HKD2_k127_7682088_45 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 311.0
HKD2_k127_7682088_46 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000084 301.0
HKD2_k127_7682088_47 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009413 295.0
HKD2_k127_7682088_48 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 286.0
HKD2_k127_7682088_49 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001953 285.0
HKD2_k127_7682088_5 Oxidoreductase - - - 5.318e-272 845.0
HKD2_k127_7682088_50 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003824 278.0
HKD2_k127_7682088_51 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002694 275.0
HKD2_k127_7682088_52 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005285 278.0
HKD2_k127_7682088_53 Uncharacterized protein conserved in bacteria (DUF2334) K06986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005098 265.0
HKD2_k127_7682088_54 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009853 263.0
HKD2_k127_7682088_55 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001935 263.0
HKD2_k127_7682088_56 protein conserved in bacteria K09986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000786 260.0
HKD2_k127_7682088_57 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003397 259.0
HKD2_k127_7682088_58 Inward rectifier potassium channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006749 250.0
HKD2_k127_7682088_59 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001985 249.0
HKD2_k127_7682088_6 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.553e-245 775.0
HKD2_k127_7682088_60 Response regulator of the LytR AlgR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000006332 239.0
HKD2_k127_7682088_61 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000000000000000000000000000006681 236.0
HKD2_k127_7682088_62 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000001016 241.0
HKD2_k127_7682088_63 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000156 237.0
HKD2_k127_7682088_64 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000006193 228.0
HKD2_k127_7682088_65 Protein of unknown function, DUF484 K09921 - - 0.0000000000000000000000000000000000000000000000000000000000000006539 224.0
HKD2_k127_7682088_66 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000000000001385 214.0
HKD2_k127_7682088_67 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000001019 207.0
HKD2_k127_7682088_68 Biopolymer transport protein K03559 - - 0.000000000000000000000000000000000000000000000000000001797 194.0
HKD2_k127_7682088_69 Biopolymer K03559 - - 0.000000000000000000000000000000000000000000000000000005546 194.0
HKD2_k127_7682088_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 1.609e-241 751.0
HKD2_k127_7682088_70 - - - - 0.00000000000000000000000000000000000000000000000000008547 191.0
HKD2_k127_7682088_71 aspartic-type endopeptidase activity - - - 0.0000000000000000000000000000000000000000000000001447 190.0
HKD2_k127_7682088_72 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000001461 181.0
HKD2_k127_7682088_73 Protein of unknown function (DUF1203) - - - 0.0000000000000000000000000000000000000000000000005932 179.0
HKD2_k127_7682088_74 Acetyltransferase (GNAT) domain K03829 - - 0.0000000000000000000000000000000000000000000003279 171.0
HKD2_k127_7682088_75 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.00000000000000000000000000000000000000000003924 168.0
HKD2_k127_7682088_76 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000248 166.0
HKD2_k127_7682088_77 - - - - 0.00000000000000000000000000000000000000002723 160.0
HKD2_k127_7682088_78 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000000000005975 141.0
HKD2_k127_7682088_79 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000006291 132.0
HKD2_k127_7682088_8 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 5.65e-226 707.0
HKD2_k127_7682088_80 TadE-like protein - - - 0.000000000000000000000000000000009863 139.0
HKD2_k127_7682088_81 TadE-like protein - - - 0.00000000000000000000003905 106.0
HKD2_k127_7682088_82 NlpC/P60 family - - - 0.000000000000000009459 89.0
HKD2_k127_7682088_83 Flp pilus assembly protein, pilin Flp K02651 - - 0.000000000000003281 76.0
HKD2_k127_7682088_84 Histidine kinase - - - 0.0000005895 63.0
HKD2_k127_7682088_85 - - - - 0.00002397 49.0
HKD2_k127_7682088_9 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 1.801e-224 702.0
HKD2_k127_7727281_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 559.0
HKD2_k127_7727281_1 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 443.0
HKD2_k127_7727281_2 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 416.0
HKD2_k127_7727281_3 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 391.0
HKD2_k127_7727281_4 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244,K19743 - 1.4.1.1,1.5.1.1,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009247 288.0
HKD2_k127_7727281_5 Threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000007549 263.0
HKD2_k127_7727281_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000006663 136.0
HKD2_k127_7727281_7 Thioesterase K01075 - 3.1.2.23 0.00000000000000000000001173 110.0
HKD2_k127_7766546_0 COG3420 Nitrous oxidase accessory protein K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008549 420.0
HKD2_k127_7766546_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 390.0
HKD2_k127_7766546_2 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992,K19341 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 374.0
HKD2_k127_7766546_3 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 341.0
HKD2_k127_7766546_4 lipoprotein involved in nitrous oxide reduction K19342 - - 0.000000000000000000000000000000000000000000000000000000000000000000000202 248.0
HKD2_k127_7766546_5 protein involved in response to NO K07234 - - 0.00000000000000000000000000000002574 128.0
HKD2_k127_7824308_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1446.0
HKD2_k127_7824308_1 peptidase S9 K01354 - 3.4.21.83 0.0 1009.0
HKD2_k127_7824308_10 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 527.0
HKD2_k127_7824308_11 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 472.0
HKD2_k127_7824308_12 Threonine aldolase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 458.0
HKD2_k127_7824308_13 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 453.0
HKD2_k127_7824308_14 Aldolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 448.0
HKD2_k127_7824308_15 FMN-dependent dehydrogenase K00101 - 1.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 444.0
HKD2_k127_7824308_16 Putative 2OG-Fe(II) oxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 439.0
HKD2_k127_7824308_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 411.0
HKD2_k127_7824308_18 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 368.0
HKD2_k127_7824308_19 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 345.0
HKD2_k127_7824308_2 aminopeptidase K01262 - 3.4.11.9 1.027e-295 918.0
HKD2_k127_7824308_20 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005135 335.0
HKD2_k127_7824308_21 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 311.0
HKD2_k127_7824308_22 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930,K22478 - 2.3.1.1,2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 293.0
HKD2_k127_7824308_23 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001425 278.0
HKD2_k127_7824308_24 maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000001361 259.0
HKD2_k127_7824308_25 Peptidase M15 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001111 253.0
HKD2_k127_7824308_26 COG1309 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000002693 236.0
HKD2_k127_7824308_27 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000133 226.0
HKD2_k127_7824308_28 thioesterase K07107 - - 0.000000000000000000000000000000000000000000000000000004425 193.0
HKD2_k127_7824308_29 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000004574 184.0
HKD2_k127_7824308_3 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 1.376e-231 720.0
HKD2_k127_7824308_30 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000004052 187.0
HKD2_k127_7824308_31 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000002426 170.0
HKD2_k127_7824308_32 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000000002698 167.0
HKD2_k127_7824308_33 Arginine repressor, DNA binding domain K03402 - - 0.00000000000000000000000000000000000000001599 158.0
HKD2_k127_7824308_34 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000002091 143.0
HKD2_k127_7824308_35 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.00000000000000000000000001983 113.0
HKD2_k127_7824308_36 Periplasmic Protein - - - 0.00000000000000000001244 100.0
HKD2_k127_7824308_37 KTSC domain - - - 0.0000000000000001426 81.0
HKD2_k127_7824308_38 - - - - 0.000000000002818 69.0
HKD2_k127_7824308_4 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 8.311e-219 684.0
HKD2_k127_7824308_42 - - - - 0.0003443 44.0
HKD2_k127_7824308_5 argininosuccinate lyase K01755 - 4.3.2.1 5.857e-213 670.0
HKD2_k127_7824308_6 Putative diguanylate phosphodiesterase - - - 1.749e-203 658.0
HKD2_k127_7824308_7 Fumarylacetoacetase K01555 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 587.0
HKD2_k127_7824308_8 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 580.0
HKD2_k127_7824308_9 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007694 535.0
HKD2_k127_78620_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.143e-314 974.0
HKD2_k127_78620_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 1.162e-202 638.0
HKD2_k127_78620_2 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 286.0
HKD2_k127_78620_3 metal-dependent hydrolase of the TIM-barrel fold K07045,K14333,K15063,K20941 - 4.1.1.103,4.1.1.46 0.000000000000000000000000000000000000000000000000001488 186.0
HKD2_k127_78620_4 Protein of unknown function (FYDLN_acid) - - - 0.0000000000000000000000000005881 118.0
HKD2_k127_78620_5 GIY-YIG catalytic domain - - - 0.00000000000002307 75.0
HKD2_k127_78620_6 signal peptide peptidase SppA K04773 - - 0.00000000002542 65.0
HKD2_k127_7883842_0 Transposase DDE domain - - - 1.853e-195 617.0
HKD2_k127_7883842_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000006042 115.0
HKD2_k127_7951765_0 Phytoene dehydrogenase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 2.888e-224 717.0
HKD2_k127_7951765_1 Type IV secretory pathway VirD2 - - - 1.459e-213 681.0
HKD2_k127_7951765_10 Fatty acid hydroxylase superfamily K15746 - 1.14.15.24 0.0000000000000000000000000000000000000000000000000000000000000000000001467 241.0
HKD2_k127_7951765_11 periplasmic protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002461 233.0
HKD2_k127_7951765_12 SOUL heme-binding protein - - - 0.000000000000000000000000000000000000000000000000000003845 201.0
HKD2_k127_7951765_13 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000001752 176.0
HKD2_k127_7951765_14 Type ii secretion system protein e - - - 0.00000000000000000000000000000000000000000000025 171.0
HKD2_k127_7951765_15 salt-induced outer membrane protein K07283 - - 0.0000000000000000000000000000000000000000000005751 179.0
HKD2_k127_7951765_16 Protein of unknown function (DUF736) - - - 0.000000000000000000000000000000000000000000008855 165.0
HKD2_k127_7951765_17 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000005406 156.0
HKD2_k127_7951765_18 Cupin domain - - - 0.00000000000000000000000000000000000005251 147.0
HKD2_k127_7951765_19 - - - - 0.000000000000000000000000000006293 129.0
HKD2_k127_7951765_2 COG0659 Sulfate permease and related transporters (MFS superfamily K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 509.0
HKD2_k127_7951765_20 OmpA family - - - 0.000000000000000000000000001262 121.0
HKD2_k127_7951765_22 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.0000000000000000002196 91.0
HKD2_k127_7951765_23 DJ-1/PfpI family - - - 0.000000000000009542 82.0
HKD2_k127_7951765_24 protein deglycation - - - 0.00000000000001038 78.0
HKD2_k127_7951765_25 AcrB/AcrD/AcrF family - - - 0.0000000003617 63.0
HKD2_k127_7951765_26 Domain of unknown function (DUF4440) - - - 0.00000006961 61.0
HKD2_k127_7951765_3 Nitrite reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 447.0
HKD2_k127_7951765_4 NnrS protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 428.0
HKD2_k127_7951765_5 sterol desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 374.0
HKD2_k127_7951765_6 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 359.0
HKD2_k127_7951765_7 Lycopene cyclase protein K06443 - 5.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 364.0
HKD2_k127_7951765_8 Phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007093 297.0
HKD2_k127_7951765_9 LytB protein K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 297.0
HKD2_k127_7952196_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 1.033e-295 917.0
HKD2_k127_7952196_1 X-Pro dipeptidyl-peptidase domain protein - - - 4.969e-263 833.0
HKD2_k127_7952196_10 Sigma-70, region 4 - - - 0.00000000000000000000000000000000000000000000000000000000000002417 220.0
HKD2_k127_7952196_11 Cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000000000000001503 193.0
HKD2_k127_7952196_12 Regulatory protein RecX K03565 - - 0.000000000000000000000000000000000000006759 159.0
HKD2_k127_7952196_13 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000001446 155.0
HKD2_k127_7952196_14 Putative zinc-finger - - - 0.00000000000000000000000000000000000003155 151.0
HKD2_k127_7952196_15 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000001708 135.0
HKD2_k127_7952196_16 Belongs to the peptidase S1C family K04771,K04772,K08070 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0031224,GO:0031226,GO:0031233,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051603,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 1.3.1.74,3.4.21.107 0.0000000000001441 82.0
HKD2_k127_7952196_17 recombinase activity - - - 0.000001164 53.0
HKD2_k127_7952196_2 Chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 617.0
HKD2_k127_7952196_3 Sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006155 456.0
HKD2_k127_7952196_4 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 428.0
HKD2_k127_7952196_5 ABC transporter K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 381.0
HKD2_k127_7952196_6 Binding-protein-dependent transport system inner membrane component K02046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 346.0
HKD2_k127_7952196_7 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005199 330.0
HKD2_k127_7952196_8 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 303.0
HKD2_k127_7952196_9 Cold shock protein domain K03704 - - 0.00000000000000000000000000000000000000000000000000000000000000376 222.0
HKD2_k127_8206479_0 TonB dependent receptor - - - 0.0 1047.0
HKD2_k127_8206479_1 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000003471 233.0
HKD2_k127_8206479_2 Protein of unknown function, DUF417 - - - 0.0000000000000000000000000000000000000000000000000000000000000002816 223.0
HKD2_k127_8206479_3 Transcriptional regulator - - - 0.00000000000000000000007866 103.0
HKD2_k127_8206479_4 Transcriptional regulator - - - 0.000000004275 66.0
HKD2_k127_8228572_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 351.0
HKD2_k127_8228572_1 Aminotransferase class v - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 338.0
HKD2_k127_8228572_2 Cytochrome c K08738 - - 0.0000000000000000000002678 104.0
HKD2_k127_8242600_0 DDE superfamily endonuclease - - - 2.037e-220 692.0
HKD2_k127_8293165_0 ABC-2 family transporter protein K13926 - - 0.0 1361.0
HKD2_k127_8293165_1 Osmosensitive K channel K07646 - 2.7.13.3 0.0 1077.0
HKD2_k127_8293165_10 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 341.0
HKD2_k127_8293165_11 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007134 338.0
HKD2_k127_8293165_12 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 304.0
HKD2_k127_8293165_13 PFAM secretion protein HlyD family protein K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002286 291.0
HKD2_k127_8293165_14 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000003113 232.0
HKD2_k127_8293165_15 Domain of unknown function (DUF4118) - - - 0.000000000000000000000000000000000000000000000000000000001117 211.0
HKD2_k127_8293165_16 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000000000000000002216 187.0
HKD2_k127_8293165_17 Biotin carboxylase - - - 0.0000000005633 67.0
HKD2_k127_8293165_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.063e-317 984.0
HKD2_k127_8293165_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 5.225e-257 803.0
HKD2_k127_8293165_4 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.896e-247 786.0
HKD2_k127_8293165_5 Sulfate permease family - - - 4.933e-232 732.0
HKD2_k127_8293165_6 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004319 546.0
HKD2_k127_8293165_7 RND efflux system, outer membrane lipoprotein K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 495.0
HKD2_k127_8293165_8 Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 375.0
HKD2_k127_8293165_9 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 341.0
HKD2_k127_847467_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 342.0
HKD2_k127_847467_1 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000005757 184.0
HKD2_k127_847467_2 Signal peptidase, peptidase S26 - - - 0.0000000000000000000000000000000000000001596 162.0
HKD2_k127_847467_3 Acetyltransferase - - - 0.0000000000000000000000002709 113.0
HKD2_k127_847467_4 Uncharacterized conserved protein (DUF2285) - - - 0.00000000000000000000001185 112.0
HKD2_k127_847467_5 Helix-turn-helix domain - - - 0.0000000000000000000001592 100.0
HKD2_k127_847467_6 Transcriptional regulator - - - 0.00000000000009022 79.0
HKD2_k127_8539882_0 Transposase (IS116 IS110 IS902 family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006703 585.0
HKD2_k127_8539882_1 transposition K07497 - - 0.000000000000000000000000000505 118.0
HKD2_k127_8539882_2 InterPro IPR001584 COGs COG2801 - - - 0.00000000000000000009273 92.0
HKD2_k127_8539882_3 Winged helix-turn helix - - - 0.000000000204 63.0
HKD2_k127_8577346_0 amino acid peptide transporter K03305 - - 1.696e-280 874.0
HKD2_k127_8577346_1 amidohydrolase - - - 9.164e-234 733.0
HKD2_k127_8577346_10 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 413.0
HKD2_k127_8577346_11 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain K12541 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 372.0
HKD2_k127_8577346_12 CHASE2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 364.0
HKD2_k127_8577346_13 Cell Wall Hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008749 335.0
HKD2_k127_8577346_15 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 304.0
HKD2_k127_8577346_16 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 300.0
HKD2_k127_8577346_17 nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000006212 219.0
HKD2_k127_8577346_18 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.000000000000000000000000000000000000000000000008273 183.0
HKD2_k127_8577346_19 Transcriptional regulator K07979 - - 0.00000000000000000000000000000000000000000000002499 172.0
HKD2_k127_8577346_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 5.858e-225 704.0
HKD2_k127_8577346_20 OmpA family - - - 0.000000000000000000000000000000000000000000007631 171.0
HKD2_k127_8577346_21 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000002276 159.0
HKD2_k127_8577346_22 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000004252 143.0
HKD2_k127_8577346_23 FecR protein - - - 0.0000000000000000000000000000000000005207 144.0
HKD2_k127_8577346_24 Periplasmic Protein - - - 0.000000000000000000000000000000000001121 147.0
HKD2_k127_8577346_25 PAP2 superfamily - - - 0.000000000000000000000000418 117.0
HKD2_k127_8577346_26 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000000001321 98.0
HKD2_k127_8577346_27 Glutaredoxin - - - 0.0000000000000000001025 102.0
HKD2_k127_8577346_28 SnoaL-like polyketide cyclase - - - 0.0000000002886 63.0
HKD2_k127_8577346_3 Belongs to the aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 2.539e-204 647.0
HKD2_k127_8577346_4 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 606.0
HKD2_k127_8577346_5 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009379 577.0
HKD2_k127_8577346_6 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 571.0
HKD2_k127_8577346_7 type I secretion membrane fusion protein K12542 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 542.0
HKD2_k127_8577346_8 dihydropteroate synthase K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 444.0
HKD2_k127_8577346_9 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 440.0
HKD2_k127_8706327_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 3.441e-216 677.0
HKD2_k127_8706327_1 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 525.0
HKD2_k127_8706327_2 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 484.0
HKD2_k127_8706327_3 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 429.0
HKD2_k127_8706327_4 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 436.0
HKD2_k127_8706327_5 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000000000000000000000000000002982 205.0
HKD2_k127_8706327_6 CDP-archaeol synthase K19664 - 2.7.7.67 0.00000000000000000000000000000000000000000001938 167.0
HKD2_k127_8706327_7 Phosphopantetheine attachment site - - - 0.0000000000000000000005427 98.0
HKD2_k127_8706327_8 permease YjgP YjgQ K11720 - - 0.000001791 50.0
HKD2_k127_8791040_0 Cytochrome C biogenesis protein transmembrane region K08970 - - 0.0000000000000000000000000000000000000000000000000000000000004164 214.0
HKD2_k127_8791040_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000001732 177.0
HKD2_k127_8791040_2 diguanylate cyclase (GGDEF domain) - - - 0.0000000000000000000000001655 108.0
HKD2_k127_8962104_0 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01469 - 3.5.2.9 0.0 1662.0
HKD2_k127_8962104_1 Efflux pump membrane transporter K18138 - - 0.0 1450.0
HKD2_k127_8962104_10 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 1.382e-231 725.0
HKD2_k127_8962104_11 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 1.884e-221 702.0
HKD2_k127_8962104_12 Sulfotransferase family - - - 3.235e-215 683.0
HKD2_k127_8962104_13 Peptidase family M28 - - - 1.217e-212 673.0
HKD2_k127_8962104_14 de-polymerase K05973 - 3.1.1.75 2e-201 633.0
HKD2_k127_8962104_15 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 9.145e-200 628.0
HKD2_k127_8962104_16 COG0729 Outer membrane protein K07278 - - 1.527e-199 643.0
HKD2_k127_8962104_17 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 624.0
HKD2_k127_8962104_18 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 603.0
HKD2_k127_8962104_19 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006916 595.0
HKD2_k127_8962104_2 protein conserved in bacteria K09800 - - 0.0 1356.0
HKD2_k127_8962104_20 Beta-lactamase class C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 602.0
HKD2_k127_8962104_21 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005878 534.0
HKD2_k127_8962104_22 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 517.0
HKD2_k127_8962104_23 type II secretion system protein K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002932 518.0
HKD2_k127_8962104_24 decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 520.0
HKD2_k127_8962104_25 Glycine cleavage system T protein K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 490.0
HKD2_k127_8962104_26 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009274 486.0
HKD2_k127_8962104_27 epimerase dehydratase K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 486.0
HKD2_k127_8962104_28 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 483.0
HKD2_k127_8962104_29 RND efflux system, outer membrane lipoprotein K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 486.0
HKD2_k127_8962104_3 Glycine dehydrogenase (aminomethyl-transferring) K00283 - 1.4.4.2 3.707e-290 899.0
HKD2_k127_8962104_30 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 481.0
HKD2_k127_8962104_31 Pilus assembly protein CpaB K02279 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 465.0
HKD2_k127_8962104_32 pilus assembly protein TadB K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 445.0
HKD2_k127_8962104_33 DNA topoisomerase K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 444.0
HKD2_k127_8962104_34 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 438.0
HKD2_k127_8962104_35 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 419.0
HKD2_k127_8962104_36 Cytochrome c1 K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000598 409.0
HKD2_k127_8962104_37 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 402.0
HKD2_k127_8962104_38 Oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 399.0
HKD2_k127_8962104_39 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 374.0
HKD2_k127_8962104_4 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 4.023e-276 854.0
HKD2_k127_8962104_40 glycosyl transferase family 8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 350.0
HKD2_k127_8962104_41 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 334.0
HKD2_k127_8962104_42 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 339.0
HKD2_k127_8962104_43 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 329.0
HKD2_k127_8962104_44 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 310.0
HKD2_k127_8962104_45 protein conserved in bacteria K09973 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 309.0
HKD2_k127_8962104_46 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 308.0
HKD2_k127_8962104_47 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000855 316.0
HKD2_k127_8962104_48 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 304.0
HKD2_k127_8962104_49 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 309.0
HKD2_k127_8962104_5 TonB-dependent Receptor Plug Domain - - - 5.646e-271 860.0
HKD2_k127_8962104_50 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 293.0
HKD2_k127_8962104_51 COG3243 Poly(3-hydroxyalkanoate) synthetase K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 298.0
HKD2_k127_8962104_52 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 292.0
HKD2_k127_8962104_53 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 285.0
HKD2_k127_8962104_54 photosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000387 274.0
HKD2_k127_8962104_55 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001637 272.0
HKD2_k127_8962104_56 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000001402 244.0
HKD2_k127_8962104_57 gag-polyprotein putative aspartyl protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001926 250.0
HKD2_k127_8962104_58 Protein of unknown function (DUF938) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001293 237.0
HKD2_k127_8962104_59 PilZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001295 240.0
HKD2_k127_8962104_6 Domain of unknown function (DUF5117) - - - 1.463e-267 847.0
HKD2_k127_8962104_60 - - - - 0.00000000000000000000000000000000000000000000000000000000000000005537 229.0
HKD2_k127_8962104_61 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000001283 223.0
HKD2_k127_8962104_62 Pilus assembly protein CpaD K02281 - - 0.000000000000000000000000000000000000000000000000000000000000009177 227.0
HKD2_k127_8962104_63 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000048 217.0
HKD2_k127_8962104_64 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000000000000000000001538 216.0
HKD2_k127_8962104_65 synthesis repressor PhaR - - - 0.0000000000000000000000000000000000000000000000000000000000009118 216.0
HKD2_k127_8962104_66 PilZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000113 213.0
HKD2_k127_8962104_67 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000001374 206.0
HKD2_k127_8962104_68 Protein of unknown function (DUF1465) K13592 - - 0.000000000000000000000000000000000000000000000000000000005596 204.0
HKD2_k127_8962104_69 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000001322 203.0
HKD2_k127_8962104_7 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 2.448e-267 842.0
HKD2_k127_8962104_70 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000002147 215.0
HKD2_k127_8962104_71 ErfK ybiS ycfS ynhG family protein - - - 0.00000000000000000000000000000000000000000000000000000135 202.0
HKD2_k127_8962104_72 protein conserved in bacteria K09973 - - 0.00000000000000000000000000000000000000000000000000008246 196.0
HKD2_k127_8962104_73 Mitochondrial fission ELM1 K07276 - - 0.000000000000000000000000000000000000000000000000002287 194.0
HKD2_k127_8962104_74 peptidase K02278 - 3.4.23.43 0.0000000000000000000000000000000000003994 152.0
HKD2_k127_8962104_75 SnoaL-like domain K06893 - - 0.0000000000000000000000000000007066 126.0
HKD2_k127_8962104_76 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000000000000000000000007953 123.0
HKD2_k127_8962104_77 Cupin domain - - - 0.00000000000000000000000000002475 120.0
HKD2_k127_8962104_78 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000002443 117.0
HKD2_k127_8962104_8 ABC-type multidrug transport system, ATPase and permease K06147 - - 3.926e-249 781.0
HKD2_k127_8962104_80 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000002154 98.0
HKD2_k127_8962104_82 - - - - 0.000000000000000000001141 98.0
HKD2_k127_8962104_83 - - - - 0.00000000000000000007599 94.0
HKD2_k127_8962104_84 - - - - 0.0000000000000000001512 95.0
HKD2_k127_8962104_85 - K06078 - - 0.000000000000000001425 88.0
HKD2_k127_8962104_9 Flp pilus assembly protein, ATPase CpaE K02282 - - 8.973e-232 723.0
HKD2_k127_8962104_90 Small protein - - - 0.000000003183 64.0
HKD2_k127_8962104_92 Protein of unknown function (DUF938) - - - 0.0000000533 54.0
HKD2_k127_8962104_96 Protein of unknown function (DUF938) - - - 0.000007517 48.0
HKD2_k127_8968728_0 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.0 1050.0
HKD2_k127_8968728_1 Recombinase zinc beta ribbon domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 489.0
HKD2_k127_8968728_2 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007154 403.0
HKD2_k127_8968728_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008729 373.0
HKD2_k127_8968728_4 Prokaryotic cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000000000000000000000000000004474 232.0
HKD2_k127_8968728_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000004529 138.0
HKD2_k127_8968728_6 Domain of unknown function (DUF202) K00389 - - 0.00000000000000000000000000000000002543 141.0
HKD2_k127_8968728_7 ABC-2 family transporter protein K01992 - - 0.000000000000000006412 84.0
HKD2_k127_8968728_8 - - - - 0.0000000101 65.0
HKD2_k127_9020324_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1030.0
HKD2_k127_9020324_1 peptidase M13 K07386 - - 1.595e-215 689.0
HKD2_k127_9020324_10 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000004949 239.0
HKD2_k127_9020324_11 Belongs to the Fur family K09823 - - 0.000000000000000000000000000000000000000000000000000000000000000001368 232.0
HKD2_k127_9020324_12 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000209 235.0
HKD2_k127_9020324_13 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.0000000000000000000000000000000000000001753 162.0
HKD2_k127_9020324_14 Dopa 4,5-dioxygenase family K10253 - - 0.0000000000000000000000000000000000000001983 153.0
HKD2_k127_9020324_15 Membrane fusogenic activity K09806 - - 0.0000000000000000000000000000003768 126.0
HKD2_k127_9020324_16 MerC mercury resistance protein - - - 0.000000000000000000000000000001774 124.0
HKD2_k127_9020324_17 NUDIX domain - - - 0.0000000000000000000000000001336 121.0
HKD2_k127_9020324_18 - - - - 0.000000000000000000000000003043 115.0
HKD2_k127_9020324_19 CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000249 106.0
HKD2_k127_9020324_2 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 479.0
HKD2_k127_9020324_21 - - - - 0.00000000000001436 82.0
HKD2_k127_9020324_22 Psort location CytoplasmicMembrane, score K00887,K00901 - 2.7.1.107,2.7.1.66 0.000000000001691 73.0
HKD2_k127_9020324_3 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006311 430.0
HKD2_k127_9020324_4 Hemolysin K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 378.0
HKD2_k127_9020324_5 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009258 299.0
HKD2_k127_9020324_6 Biotin carboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 303.0
HKD2_k127_9020324_7 PFAM CHAD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000211 297.0
HKD2_k127_9020324_8 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001658 278.0
HKD2_k127_9020324_9 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000275 268.0
HKD2_k127_9050156_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1796.0
HKD2_k127_9050156_1 Protein of unknown function (DUF1254) - - - 2.573e-209 662.0
HKD2_k127_9050156_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 294.0
HKD2_k127_9050156_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001427 281.0
HKD2_k127_9050156_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000000000000000002488 205.0
HKD2_k127_9050156_5 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000000000000000000000001329 197.0
HKD2_k127_9050156_6 - - - - 0.0000000000000001945 82.0
HKD2_k127_9081658_0 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006806 555.0
HKD2_k127_9081658_1 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 482.0
HKD2_k127_9081658_2 - - - - 0.00000000000000000000000000000000000008235 150.0
HKD2_k127_9081658_3 SnoaL-like domain - - - 0.0000000000000000000000000000000000002162 144.0
HKD2_k127_9100247_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 335.0
HKD2_k127_9100247_1 Nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000001063 216.0
HKD2_k127_9100247_2 Helix-turn-helix XRE-family like proteins K07726 - - 0.000000000000000000000000007313 112.0
HKD2_k127_9105573_0 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003816 384.0
HKD2_k127_9105573_1 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 281.0
HKD2_k127_9151697_0 Polysaccharide deacetylase K22278 - 3.5.1.104 0.0 1343.0
HKD2_k127_9151697_1 helicase K03724 - - 0.0 1212.0
HKD2_k127_9151697_10 acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 2.452e-310 965.0
HKD2_k127_9151697_100 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000007781 175.0
HKD2_k127_9151697_101 - - - - 0.000000000000000000000000000000000000000000001745 168.0
HKD2_k127_9151697_102 GtrA-like protein - - - 0.00000000000000000000000000000000000000000001163 166.0
HKD2_k127_9151697_103 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000166 159.0
HKD2_k127_9151697_104 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000000000000000000002095 159.0
HKD2_k127_9151697_105 FOG TPR repeat, SEL1 subfamily K07126 - - 0.00000000000000000000000000000000000001164 146.0
HKD2_k127_9151697_106 - - - - 0.00000000000000000000000000000000000002878 153.0
HKD2_k127_9151697_107 Redoxin - - - 0.000000000000000000000000000000003417 135.0
HKD2_k127_9151697_108 Diacylglycerol kinase - - - 0.00000000000000000000000000000001651 132.0
HKD2_k127_9151697_109 Belongs to the UPF0335 family - - - 0.000000000000000000000000000001695 122.0
HKD2_k127_9151697_11 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 9.243e-310 961.0
HKD2_k127_9151697_110 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000002783 133.0
HKD2_k127_9151697_111 invasion associated locus B - - - 0.000000000000000000000000000008172 124.0
HKD2_k127_9151697_112 GtrA-like protein - - - 0.00000000000000000000000000005496 121.0
HKD2_k127_9151697_113 - - - - 0.000000000000000000000000002603 118.0
HKD2_k127_9151697_114 Transcriptional regulator K07729 - - 0.00000000000000000000000009897 108.0
HKD2_k127_9151697_115 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.0000000000000000000000001796 115.0
HKD2_k127_9151697_116 integral membrane protein K02221 - - 0.0000000000000000000000001814 108.0
HKD2_k127_9151697_117 Tetratricopeptide repeat - - - 0.000000000000000000000002127 112.0
HKD2_k127_9151697_118 EF-hand, calcium binding motif - - - 0.0000000000000000000533 99.0
HKD2_k127_9151697_119 - - - - 0.00000000000000000007143 92.0
HKD2_k127_9151697_12 Domain of unknown function DUF87 K06915 - - 1.07e-296 917.0
HKD2_k127_9151697_120 Belongs to the ompA family K03640 - - 0.000000000000000001402 91.0
HKD2_k127_9151697_121 - - - - 0.000000000000000002792 87.0
HKD2_k127_9151697_122 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.000000000000000003317 86.0
HKD2_k127_9151697_123 - - - - 0.00000000000000001282 91.0
HKD2_k127_9151697_124 COG2826 Transposase and inactivated derivatives, IS30 family - - - 0.00000000000002406 76.0
HKD2_k127_9151697_125 - - - - 0.00000000000005184 76.0
HKD2_k127_9151697_126 - - - - 0.000000000003619 73.0
HKD2_k127_9151697_127 - - - - 0.000000000005037 70.0
HKD2_k127_9151697_129 Belongs to the ompA family - - - 0.000006666 57.0
HKD2_k127_9151697_13 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 2.023e-294 907.0
HKD2_k127_9151697_14 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 9.605e-289 889.0
HKD2_k127_9151697_15 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 8.991e-277 866.0
HKD2_k127_9151697_16 synthetase K01897 - 6.2.1.3 1.642e-276 861.0
HKD2_k127_9151697_17 Thi4 family - - - 8.225e-270 837.0
HKD2_k127_9151697_18 Sulfotransferase family - - - 2.832e-260 823.0
HKD2_k127_9151697_19 single-stranded-DNA-specific exonuclease RecJ K07462 - - 1.072e-245 771.0
HKD2_k127_9151697_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1212.0
HKD2_k127_9151697_20 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.189e-237 747.0
HKD2_k127_9151697_21 Subtilase family - - - 1.592e-235 754.0
HKD2_k127_9151697_22 phosphomannomutase K01840 - 5.4.2.8 3.158e-231 722.0
HKD2_k127_9151697_23 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 2.746e-227 705.0
HKD2_k127_9151697_24 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 2.077e-222 692.0
HKD2_k127_9151697_25 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 2.246e-213 672.0
HKD2_k127_9151697_26 oligosaccharyl transferase activity - - - 3.943e-212 676.0
HKD2_k127_9151697_27 Peptidase dimerisation domain - - - 2.324e-199 633.0
HKD2_k127_9151697_28 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 596.0
HKD2_k127_9151697_29 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 608.0
HKD2_k127_9151697_3 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 0.0 1209.0
HKD2_k127_9151697_30 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 590.0
HKD2_k127_9151697_31 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 567.0
HKD2_k127_9151697_32 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 566.0
HKD2_k127_9151697_33 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 537.0
HKD2_k127_9151697_34 in Escherichia coli this protein forms a dimer and binds manganese K11532 - 3.1.3.11,3.1.3.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005219 515.0
HKD2_k127_9151697_35 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes K00957 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 512.0
HKD2_k127_9151697_36 Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007811 501.0
HKD2_k127_9151697_37 synthase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 498.0
HKD2_k127_9151697_38 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 494.0
HKD2_k127_9151697_39 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 474.0
HKD2_k127_9151697_4 helicase K17675 - 3.6.4.13 0.0 1196.0
HKD2_k127_9151697_40 Protein of unknown function (DUF3089) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000721 466.0
HKD2_k127_9151697_41 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 447.0
HKD2_k127_9151697_42 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009448 437.0
HKD2_k127_9151697_43 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 441.0
HKD2_k127_9151697_44 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004476 430.0
HKD2_k127_9151697_45 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008511 434.0
HKD2_k127_9151697_46 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 431.0
HKD2_k127_9151697_47 ABC-type transport system involved in Fe-S cluster assembly, ATPase component K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009006 409.0
HKD2_k127_9151697_48 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 396.0
HKD2_k127_9151697_49 Histidine-specific methyltransferase, SAM-dependent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009515 400.0
HKD2_k127_9151697_5 Malic enzyme K00029 - 1.1.1.40 0.0 1191.0
HKD2_k127_9151697_50 involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 405.0
HKD2_k127_9151697_51 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 398.0
HKD2_k127_9151697_52 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 405.0
HKD2_k127_9151697_53 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 380.0
HKD2_k127_9151697_54 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 373.0
HKD2_k127_9151697_55 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007733 372.0
HKD2_k127_9151697_56 HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 362.0
HKD2_k127_9151697_57 Phosphoglycerate mutase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 362.0
HKD2_k127_9151697_58 Putative transmembrane protein (Alph_Pro_TM) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 365.0
HKD2_k127_9151697_59 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 348.0
HKD2_k127_9151697_6 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0 1176.0
HKD2_k127_9151697_60 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 334.0
HKD2_k127_9151697_61 Hydrolase K07025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 330.0
HKD2_k127_9151697_62 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 325.0
HKD2_k127_9151697_63 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 326.0
HKD2_k127_9151697_64 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 325.0
HKD2_k127_9151697_65 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 313.0
HKD2_k127_9151697_66 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 301.0
HKD2_k127_9151697_67 Protein of unknown function (DUF541) K09797 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 302.0
HKD2_k127_9151697_68 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 306.0
HKD2_k127_9151697_69 MltA-interacting protein MipA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 302.0
HKD2_k127_9151697_7 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1119.0
HKD2_k127_9151697_70 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 293.0
HKD2_k127_9151697_71 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 291.0
HKD2_k127_9151697_72 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 286.0
HKD2_k127_9151697_73 methyltransferase activity K21310 - 2.1.1.334 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 285.0
HKD2_k127_9151697_74 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004543 291.0
HKD2_k127_9151697_75 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000206 279.0
HKD2_k127_9151697_76 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005337 282.0
HKD2_k127_9151697_77 ABC-type transport system involved in Fe-S cluster assembly, permease component K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006206 273.0
HKD2_k127_9151697_78 glutamine amidotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007812 270.0
HKD2_k127_9151697_79 Chromosome partitioning - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004877 261.0
HKD2_k127_9151697_8 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0 1073.0
HKD2_k127_9151697_80 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001219 260.0
HKD2_k127_9151697_81 UPF0056 membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003083 262.0
HKD2_k127_9151697_82 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000003377 251.0
HKD2_k127_9151697_83 COG0346 Lactoylglutathione lyase and related lyases K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000523 247.0
HKD2_k127_9151697_84 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008758 248.0
HKD2_k127_9151697_85 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000000000000000000000005464 241.0
HKD2_k127_9151697_86 FeS assembly SUF system protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002138 241.0
HKD2_k127_9151697_87 methylmalonyl-CoA epimerase K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000004302 235.0
HKD2_k127_9151697_88 adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000004506 239.0
HKD2_k127_9151697_89 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000000000000000000000002794 226.0
HKD2_k127_9151697_9 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0 1035.0
HKD2_k127_9151697_90 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000000000000000000000000000000000006598 217.0
HKD2_k127_9151697_91 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000001292 215.0
HKD2_k127_9151697_92 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000000000000000004567 192.0
HKD2_k127_9151697_93 - - - - 0.000000000000000000000000000000000000000000000000000007097 201.0
HKD2_k127_9151697_94 Putative esterase K07017 - - 0.0000000000000000000000000000000000000000000000000001213 200.0
HKD2_k127_9151697_95 Redox protein regulator of disulfide bond formation - - - 0.0000000000000000000000000000000000000000000000000001909 190.0
HKD2_k127_9151697_96 thioesterase K07107 - - 0.000000000000000000000000000000000000000000000000009215 189.0
HKD2_k127_9151697_97 transcriptional - - - 0.000000000000000000000000000000000000000000000000024 185.0
HKD2_k127_9151697_98 - - - - 0.0000000000000000000000000000000000000000000000003795 182.0
HKD2_k127_9151697_99 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000000000000000000000001013 176.0
HKD2_k127_9172197_0 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 1.414e-201 640.0
HKD2_k127_9172197_1 NAD(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 534.0
HKD2_k127_9172197_2 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009654 506.0
HKD2_k127_9172197_3 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006945 382.0
HKD2_k127_9172197_4 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 319.0
HKD2_k127_9172197_5 Aminoacyl-tRNA editing domain - - - 0.000000000000000000000000000000000000000000000000004513 186.0
HKD2_k127_9172197_6 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000487 173.0
HKD2_k127_9270401_0 Helicase K03722 - 3.6.4.12 0.0 1297.0
HKD2_k127_9270401_1 Belongs to the AAA ATPase family K13525 - - 0.0 1280.0
HKD2_k127_9270401_10 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004651 598.0
HKD2_k127_9270401_11 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009423 571.0
HKD2_k127_9270401_12 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 541.0
HKD2_k127_9270401_13 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 527.0
HKD2_k127_9270401_14 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 514.0
HKD2_k127_9270401_15 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 507.0
HKD2_k127_9270401_16 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 485.0
HKD2_k127_9270401_17 tail specific protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 486.0
HKD2_k127_9270401_18 Sulfatase-modifying factor enzyme 1 K20333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 475.0
HKD2_k127_9270401_19 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 481.0
HKD2_k127_9270401_2 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 0.0 1245.0
HKD2_k127_9270401_20 Electron transfer flavoprotein K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 452.0
HKD2_k127_9270401_21 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 448.0
HKD2_k127_9270401_22 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 450.0
HKD2_k127_9270401_23 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 452.0
HKD2_k127_9270401_24 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 442.0
HKD2_k127_9270401_25 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 436.0
HKD2_k127_9270401_26 Glutaminase K01425 - 3.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 423.0
HKD2_k127_9270401_27 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 402.0
HKD2_k127_9270401_28 Aldose 1-epimerase K01785 - 5.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 387.0
HKD2_k127_9270401_29 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 354.0
HKD2_k127_9270401_3 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1035.0
HKD2_k127_9270401_30 ICC-like phosphoesterases K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 332.0
HKD2_k127_9270401_31 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007311 319.0
HKD2_k127_9270401_32 CarD family transcriptional regulator K07736 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 310.0
HKD2_k127_9270401_33 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 306.0
HKD2_k127_9270401_34 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 299.0
HKD2_k127_9270401_35 isomerase K01809 - 5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 289.0
HKD2_k127_9270401_36 KR domain K07124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 288.0
HKD2_k127_9270401_37 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000002219 267.0
HKD2_k127_9270401_38 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000004054 262.0
HKD2_k127_9270401_39 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008129 258.0
HKD2_k127_9270401_4 protein conserved in bacteria - - - 8.284e-270 844.0
HKD2_k127_9270401_40 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007992 256.0
HKD2_k127_9270401_41 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000000000000000000000000000000000000000007781 238.0
HKD2_k127_9270401_42 ribonuclease E activity - - - 0.00000000000000000000000000000000000000000000000000000000000001878 226.0
HKD2_k127_9270401_43 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 GO:0005575,GO:0005576 1.3.3.11 0.000000000000000000000000000000000000000000000000000000000003956 214.0
HKD2_k127_9270401_44 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000003413 199.0
HKD2_k127_9270401_45 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000003873 193.0
HKD2_k127_9270401_46 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000472 180.0
HKD2_k127_9270401_47 AsnC-type helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000003091 181.0
HKD2_k127_9270401_48 endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000000002498 174.0
HKD2_k127_9270401_49 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000000002882 170.0
HKD2_k127_9270401_5 Sulfatase K01130 - 3.1.6.1 5.971e-262 816.0
HKD2_k127_9270401_50 phosphohistidine phosphatase K08296 - - 0.000000000000000000000000000000000000000000001161 171.0
HKD2_k127_9270401_51 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000000000000002164 164.0
HKD2_k127_9270401_52 Protein of unknown function (DUF1489) - - - 0.00000000000000000000000000000000000000000008081 163.0
HKD2_k127_9270401_53 Protein of unknown function (DUF2721) - - - 0.000000000000000000000000000000000000000000165 164.0
HKD2_k127_9270401_54 Protein of unknown function (DUF3313) - - - 0.000000000000000000000000000000000000000002804 164.0
HKD2_k127_9270401_55 Putative auto-transporter adhesin, head GIN domain - - - 0.000000000000000000000000000000000000000003562 164.0
HKD2_k127_9270401_56 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000008373 142.0
HKD2_k127_9270401_57 transcriptional - - - 0.0000000000000000000000000000000007235 134.0
HKD2_k127_9270401_58 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000000000000000000000000000007388 139.0
HKD2_k127_9270401_59 Bile acid K03453 - - 0.000000000000000000000000000000005583 141.0
HKD2_k127_9270401_6 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 1.32e-246 771.0
HKD2_k127_9270401_60 Domain of unknown function (DUF202) K00389 - - 0.000000000000000000000000000000009924 133.0
HKD2_k127_9270401_61 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000000000000000001221 126.0
HKD2_k127_9270401_62 Ion channel - - - 0.000000000000000000000000000001841 129.0
HKD2_k127_9270401_63 Protein of unknown function (DUF1622) - - - 0.00000000000000000000000000004357 121.0
HKD2_k127_9270401_64 Nickel/cobalt transporter regulator - - - 0.0000000000000000000000000000805 129.0
HKD2_k127_9270401_66 - - - - 0.0000000000000000000000101 108.0
HKD2_k127_9270401_67 Domain of unknown function (DUF4136) - - - 0.00000000000000000000003402 106.0
HKD2_k127_9270401_68 component I K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000002328 98.0
HKD2_k127_9270401_69 Cyclic nucleotide-monophosphate binding domain K10914 - - 0.0000000000000000000009503 104.0
HKD2_k127_9270401_7 PFAM sulfatase K01130 - 3.1.6.1 1.423e-245 768.0
HKD2_k127_9270401_70 Domain of unknown function (DUF4136) - - - 0.000000000000000002627 92.0
HKD2_k127_9270401_71 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000000001139 85.0
HKD2_k127_9270401_73 ketosteroid isomerase - - - 0.000000004213 67.0
HKD2_k127_9270401_74 Resolvase - - - 0.0000001587 55.0
HKD2_k127_9270401_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 2.118e-217 680.0
HKD2_k127_9270401_9 Acts as a magnesium transporter K06213 - - 1.512e-211 667.0
HKD2_k127_9310446_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1380.0
HKD2_k127_9310446_1 DNA polymerase K02337 - 2.7.7.7 0.0 1341.0
HKD2_k127_9310446_10 cystathionine beta-lyase K01760 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 454.0
HKD2_k127_9310446_11 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 447.0
HKD2_k127_9310446_12 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 437.0
HKD2_k127_9310446_13 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 404.0
HKD2_k127_9310446_14 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 382.0
HKD2_k127_9310446_15 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 366.0
HKD2_k127_9310446_16 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 359.0
HKD2_k127_9310446_17 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 355.0
HKD2_k127_9310446_18 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 323.0
HKD2_k127_9310446_19 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 288.0
HKD2_k127_9310446_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1116.0
HKD2_k127_9310446_20 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000000001504 259.0
HKD2_k127_9310446_21 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004232 254.0
HKD2_k127_9310446_23 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000004428 197.0
HKD2_k127_9310446_24 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000001761 195.0
HKD2_k127_9310446_25 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000008749 190.0
HKD2_k127_9310446_26 Outer membrane protein (OmpH-like) - - - 0.000000000000000000000000000000000000000000324 164.0
HKD2_k127_9310446_27 TIR domain - - - 0.00000000000000000000000000000000000009943 162.0
HKD2_k127_9310446_28 Helix-turn-helix K21498 - - 0.000000000000000000000000000009784 122.0
HKD2_k127_9310446_29 RelE-like toxin of type II toxin-antitoxin system HigB - - - 0.0000000000000004539 78.0
HKD2_k127_9310446_3 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 1.407e-238 741.0
HKD2_k127_9310446_30 Peptidase inhibitor I9 K20754 - 3.4.21.111 0.000000001252 70.0
HKD2_k127_9310446_31 Involved in the tonB-independent uptake of proteins - - - 0.000001536 51.0
HKD2_k127_9310446_4 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.184e-237 739.0
HKD2_k127_9310446_5 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 1.802e-201 644.0
HKD2_k127_9310446_6 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009737 608.0
HKD2_k127_9310446_7 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 497.0
HKD2_k127_9310446_8 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005446 464.0
HKD2_k127_9310446_9 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 454.0
HKD2_k127_9331086_0 Integrase core domain K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 522.0
HKD2_k127_9331086_1 Transposase K07497 - - 0.000000000000000000000000000000000003242 138.0
HKD2_k127_9342622_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 2557.0
HKD2_k127_9342622_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 3.768e-263 856.0
HKD2_k127_9342622_10 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000001477 92.0
HKD2_k127_9342622_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 2.556e-252 783.0
HKD2_k127_9342622_3 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 467.0
HKD2_k127_9342622_4 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 374.0
HKD2_k127_9342622_5 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000115 287.0
HKD2_k127_9342622_6 Bacterial transcriptional activator domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000006292 258.0
HKD2_k127_9342622_7 Domain of unknown function (DUF4956) - - - 0.00000000000000000000000000000000000000000000000000000000009911 212.0
HKD2_k127_9342622_8 DNA helicase - - - 0.000000000000000000000182 114.0
HKD2_k127_9342622_9 DNA helicase - - - 0.0000000000000000000003023 113.0
HKD2_k127_9655635_0 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006527 470.0
HKD2_k127_9655635_1 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 326.0
HKD2_k127_9655635_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000004892 138.0
HKD2_k127_9655635_3 - - - - 0.0000000000000000000000000000493 121.0
HKD2_k127_9788736_0 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 1.822e-299 935.0
HKD2_k127_9788736_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 6.563e-256 796.0
HKD2_k127_9788736_10 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 453.0
HKD2_k127_9788736_11 Lytic murein transglycosylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 399.0
HKD2_k127_9788736_12 LuxR family transcriptional regulator K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 386.0
HKD2_k127_9788736_13 BlaR1 peptidase M56 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 402.0
HKD2_k127_9788736_14 DNA polymerase K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 351.0
HKD2_k127_9788736_15 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 343.0
HKD2_k127_9788736_16 MazG family K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 326.0
HKD2_k127_9788736_17 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008264 326.0
HKD2_k127_9788736_18 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 289.0
HKD2_k127_9788736_19 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001572 276.0
HKD2_k127_9788736_2 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K13599 - - 1.568e-233 728.0
HKD2_k127_9788736_20 gag-polyprotein putative aspartyl protease K06985 - - 0.00000000000000000000000000000000000000000000000000000000000000000001212 238.0
HKD2_k127_9788736_21 Belongs to the CinA family K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000003168 237.0
HKD2_k127_9788736_22 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000004086 231.0
HKD2_k127_9788736_23 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000000000000000000000000002302 209.0
HKD2_k127_9788736_24 Peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000002177 201.0
HKD2_k127_9788736_25 Protein of unknown function (DUF3313) - - - 0.000000000000000000000000000000000000000000000000212 186.0
HKD2_k127_9788736_26 Penicillinase repressor - - - 0.00000000000000000000000000000000000000000000004488 171.0
HKD2_k127_9788736_27 PAS domain - - - 0.000000000000000000000000000000000000000000004816 169.0
HKD2_k127_9788736_28 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000004528 158.0
HKD2_k127_9788736_29 Oligoketide cyclase lipid transport protein K18588 - - 0.0000000000000000000000000000000000000004503 157.0
HKD2_k127_9788736_3 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 7.594e-221 708.0
HKD2_k127_9788736_30 - - - - 0.00000000000000000000000002893 112.0
HKD2_k127_9788736_32 Glycosyl transferase family 41 - - - 0.0001198 51.0
HKD2_k127_9788736_4 acyl-CoA dehydrogenase K00252 - 1.3.8.6 2.522e-217 681.0
HKD2_k127_9788736_5 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007737 598.0
HKD2_k127_9788736_6 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 557.0
HKD2_k127_9788736_7 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 548.0
HKD2_k127_9788736_8 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 534.0
HKD2_k127_9788736_9 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 544.0
HKD2_k127_9815420_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 0.0 1138.0
HKD2_k127_9815420_1 aminopeptidase N K01256 - 3.4.11.2 0.0 1104.0
HKD2_k127_9815420_10 Putative MetA-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000001163 184.0
HKD2_k127_9815420_11 - - - - 0.0000000000000000000000000000000000000000003582 161.0
HKD2_k127_9815420_12 - - - - 0.0000000000000000000000000000000013 132.0
HKD2_k127_9815420_13 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.0000000000000000000000000000007671 126.0
HKD2_k127_9815420_14 Cupin domain - - - 0.00000000000000000000000000002564 123.0
HKD2_k127_9815420_16 SnoaL-like polyketide cyclase - - - 0.00000000000037 76.0
HKD2_k127_9815420_18 nuclease - - - 0.000000003142 65.0
HKD2_k127_9815420_2 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 1.503e-213 665.0
HKD2_k127_9815420_3 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 515.0
HKD2_k127_9815420_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 449.0
HKD2_k127_9815420_5 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 433.0
HKD2_k127_9815420_6 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 411.0
HKD2_k127_9815420_7 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 345.0
HKD2_k127_9815420_8 MobA-like NTP transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002087 268.0
HKD2_k127_9815420_9 transport system auxiliary component K18480 - - 0.000000000000000000000000000000000000000000000000009132 189.0
HKD2_k127_9853109_0 III protein, CoA-transferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 371.0
HKD2_k127_9853109_1 Acyl-CoA dehydrogenase, C-terminal domain K06446 - - 0.0000000000000000000000000000000000000000000000004353 179.0
HKD2_k127_9853109_2 PFAM ABC transporter K01996 - - 0.000000000000000000000000000000000001722 141.0
HKD2_k127_9937444_0 DNA helicase K03657 - 3.6.4.12 0.0 1227.0
HKD2_k127_9937444_1 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1193.0
HKD2_k127_9937444_10 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 2.715e-197 618.0
HKD2_k127_9937444_11 Aminotransferase class-III K00822 - 2.6.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006681 582.0
HKD2_k127_9937444_12 Erythromycin esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 580.0
HKD2_k127_9937444_13 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 556.0
HKD2_k127_9937444_14 beta-lactamase K01467 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 547.0
HKD2_k127_9937444_15 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 531.0
HKD2_k127_9937444_16 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 484.0
HKD2_k127_9937444_17 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007411 488.0
HKD2_k127_9937444_18 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006048 463.0
HKD2_k127_9937444_19 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 460.0
HKD2_k127_9937444_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.412e-320 987.0
HKD2_k127_9937444_20 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 452.0
HKD2_k127_9937444_21 protein conserved in bacteria K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 448.0
HKD2_k127_9937444_22 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005158 447.0
HKD2_k127_9937444_23 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 434.0
HKD2_k127_9937444_24 Transcriptional regulator K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 434.0
HKD2_k127_9937444_25 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 427.0
HKD2_k127_9937444_26 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 429.0
HKD2_k127_9937444_27 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 412.0
HKD2_k127_9937444_28 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 418.0
HKD2_k127_9937444_29 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 395.0
HKD2_k127_9937444_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 6.064e-308 949.0
HKD2_k127_9937444_30 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 391.0
HKD2_k127_9937444_31 asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 390.0
HKD2_k127_9937444_32 protein conserved in bacteria K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005218 379.0
HKD2_k127_9937444_33 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 358.0
HKD2_k127_9937444_34 serine acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 347.0
HKD2_k127_9937444_35 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006328 347.0
HKD2_k127_9937444_36 protein conserved in bacteria K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 314.0
HKD2_k127_9937444_37 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 306.0
HKD2_k127_9937444_38 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 291.0
HKD2_k127_9937444_39 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005781 294.0
HKD2_k127_9937444_4 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 3.15e-280 875.0
HKD2_k127_9937444_40 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 287.0
HKD2_k127_9937444_41 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000009521 263.0
HKD2_k127_9937444_42 PFAM inositol monophosphatase K01082 - 3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000001172 261.0
HKD2_k127_9937444_43 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000002956 245.0
HKD2_k127_9937444_44 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002903 243.0
HKD2_k127_9937444_45 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000006121 241.0
HKD2_k127_9937444_46 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000000000000007782 221.0
HKD2_k127_9937444_48 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000002696 215.0
HKD2_k127_9937444_49 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000002593 201.0
HKD2_k127_9937444_5 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 1.481e-247 768.0
HKD2_k127_9937444_50 Protein of unknown function (DUF4230) - - - 0.000000000000000000000000000000000000000000000000000004262 198.0
HKD2_k127_9937444_51 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.0000000000000000000000000000000000000000000000001383 177.0
HKD2_k127_9937444_52 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000126 175.0
HKD2_k127_9937444_53 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000001493 175.0
HKD2_k127_9937444_54 NADH ubiquinone oxidoreductase 17.2 kD subunit - - - 0.0000000000000000000000000000000000000000000004334 171.0
HKD2_k127_9937444_55 Protein of unknown function (DUF2794) - - - 0.000000000000000000000000000000000000000000001652 167.0
HKD2_k127_9937444_56 PFAM Glutathione S-transferase domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000002724 171.0
HKD2_k127_9937444_57 Domain of unknown function (DUF4112) - - - 0.00000000000000000000000000000000000000000002597 165.0
HKD2_k127_9937444_58 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.0000000000000000000000000000000000000000001011 162.0
HKD2_k127_9937444_59 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000001753 164.0
HKD2_k127_9937444_6 metal-dependent hydrolase with the TIM-barrel fold - - - 2.22e-236 743.0
HKD2_k127_9937444_60 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. - - - 0.000000000000000000000000000000000000000001445 164.0
HKD2_k127_9937444_61 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000001906 168.0
HKD2_k127_9937444_62 response regulator - - - 0.00000000000000000000000000000000000001084 149.0
HKD2_k127_9937444_63 PFAM Sterol-binding domain protein - - - 0.00000000000000000000000000000000000006843 144.0
HKD2_k127_9937444_64 Protein of unknown function (FYDLN_acid) - - - 0.00000000000000000000000000000000000007935 146.0
HKD2_k127_9937444_65 ArsC family K00537 - 1.20.4.1 0.0000000000000000000000000000000000001719 143.0
HKD2_k127_9937444_66 Domain of unknown function (DUF1476) - - - 0.00000000000000000000000000000000000586 141.0
HKD2_k127_9937444_67 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000003343 132.0
HKD2_k127_9937444_68 Belongs to the BolA IbaG family - - - 0.000000000000000000000000000000555 124.0
HKD2_k127_9937444_69 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000001298 122.0
HKD2_k127_9937444_7 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 4.97e-223 699.0
HKD2_k127_9937444_70 Pfam Methyltransferase - - - 0.00000000000000000000000000199 123.0
HKD2_k127_9937444_71 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000002316 117.0
HKD2_k127_9937444_72 Pfam:DUF1049 K08992 - - 0.00000000000000000000000005211 111.0
HKD2_k127_9937444_73 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000234 111.0
HKD2_k127_9937444_74 acetyltransferase K06975 - - 0.000000000000000000000003755 104.0
HKD2_k127_9937444_75 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000000000000001424 107.0
HKD2_k127_9937444_76 Low affinity iron permease - - - 0.0000000000000000000000552 104.0
HKD2_k127_9937444_77 - - - - 0.000000000000000000001585 108.0
HKD2_k127_9937444_78 ACT domain - - - 0.000000000000000000002057 97.0
HKD2_k127_9937444_79 Protein of unknown function (DUF4239) - - - 0.00000000000000000005645 100.0
HKD2_k127_9937444_8 Acetyl-coenzyme A transporter 1 K08218 - - 6.816e-220 695.0
HKD2_k127_9937444_80 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000003711 92.0
HKD2_k127_9937444_81 helix_turn_helix ASNC type - - - 0.0000000000000002095 86.0
HKD2_k127_9937444_82 Flp pilus assembly protein, pilin Flp K02651 - - 0.000000000000002961 77.0
HKD2_k127_9937444_83 Outer membrane lipoprotein - - - 0.000000000000003016 79.0
HKD2_k127_9937444_84 - - - - 0.00000000000002755 76.0
HKD2_k127_9937444_85 - - - - 0.00000000000006507 81.0
HKD2_k127_9937444_86 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000003947 70.0
HKD2_k127_9937444_88 PilZ domain - - - 0.000184 51.0
HKD2_k127_9937444_9 Sugar (and other) transporter - - - 2.278e-197 623.0