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Overview

ID MAG01788
Name HKD2_bin.30
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Desulfobacterota
Class Desulfobulbia
Order Desulfobulbales
Family Desulfobulbaceae
Genus UBA10518
Species
Assembly information
Completeness (%) 94.22
Contamination (%) 4.68
GC content (%) 63.0
N50 (bp) 9,459
Genome size (bp) 3,168,671

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2821

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10000605_0 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000001168 179.0
HKD2_k127_10000605_1 ribonucleoside-diphosphate reductase activity K00525,K00526 - 1.17.4.1 0.000000000000000000000000000000000000001247 148.0
HKD2_k127_10000605_2 SdpI/YhfL protein family - - - 0.00000001311 61.0
HKD2_k127_10000605_3 - - - - 0.000002343 51.0
HKD2_k127_10008632_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 320.0
HKD2_k127_10008632_1 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000002789 237.0
HKD2_k127_10008632_2 lysyltransferase activity K07027 - - 0.0000000000000000000000000000000000001072 163.0
HKD2_k127_10015730_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 1.52e-214 678.0
HKD2_k127_10021095_0 sulphate transporter K03321 - - 7.178e-225 711.0
HKD2_k127_10021095_1 Collagenase K08303 - - 1.296e-219 702.0
HKD2_k127_10021095_10 4 iron, 4 sulfur cluster binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 316.0
HKD2_k127_10021095_11 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007794 248.0
HKD2_k127_10021095_12 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000004876 241.0
HKD2_k127_10021095_13 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000001167 229.0
HKD2_k127_10021095_14 Appr-1'-p processing enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000002124 219.0
HKD2_k127_10021095_15 chondroitin AC lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000007411 228.0
HKD2_k127_10021095_16 MarR family transcriptional K15973 - - 0.00000000000000000000000000000000368 134.0
HKD2_k127_10021095_2 Domain of unknown function (DUF4445) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 572.0
HKD2_k127_10021095_3 PFAM phosphoesterase RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 528.0
HKD2_k127_10021095_4 permease YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 493.0
HKD2_k127_10021095_5 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 473.0
HKD2_k127_10021095_6 methionine sulfoxide reductase K07305,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008251 394.0
HKD2_k127_10021095_7 cell wall binding repeat 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 404.0
HKD2_k127_10021095_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 320.0
HKD2_k127_10021095_9 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 316.0
HKD2_k127_10055870_0 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007838 554.0
HKD2_k127_10055870_1 Transcriptional activator domain - - - 0.000000000000000000000000000000000000000003658 161.0
HKD2_k127_10058341_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 452.0
HKD2_k127_10058341_1 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000000000000000000000000000001078 161.0
HKD2_k127_10058341_2 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000003562 153.0
HKD2_k127_10058341_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000004815 72.0
HKD2_k127_10070283_0 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000002211 217.0
HKD2_k127_10070283_2 cellulose 1,4-beta-cellobiosidase activity K01278,K01727,K03561,K12287,K21449 - 3.4.14.5,4.2.2.1 0.00000000000000000000000244 107.0
HKD2_k127_10070283_3 Methyltransferase domain - - - 0.00000000002876 75.0
HKD2_k127_10092143_0 SNF2 family N-terminal domain - - - 1.214e-226 706.0
HKD2_k127_10092143_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000007558 116.0
HKD2_k127_10100308_0 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 431.0
HKD2_k127_10100308_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0000000000000000000000000002039 115.0
HKD2_k127_10144754_0 type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 606.0
HKD2_k127_10144754_1 General secretion pathway protein C K02452 - - 0.0000000000000000000000000000000000000000000000000000002638 206.0
HKD2_k127_10144754_2 type II secretion system protein E K02454 - - 0.00000000000000000000001502 106.0
HKD2_k127_10156686_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1911.0
HKD2_k127_10156686_1 Voltage gated chloride channel K03281 - - 1.716e-279 881.0
HKD2_k127_10156686_2 chorismate binding enzyme K01665,K03342 - 2.6.1.85,4.1.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000651 548.0
HKD2_k127_10156686_3 SMART metal-dependent phosphohydrolase HD region K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 490.0
HKD2_k127_10156686_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 373.0
HKD2_k127_10156686_5 PFAM CBS domain containing protein K04767 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 314.0
HKD2_k127_10156686_6 - - - - 0.00000000000005077 73.0
HKD2_k127_10168451_0 AMP-binding enzyme K00666 - - 0.0 1036.0
HKD2_k127_10168451_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 3.519e-194 631.0
HKD2_k127_10168451_2 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 461.0
HKD2_k127_10168451_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003048 278.0
HKD2_k127_1028521_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.292e-200 640.0
HKD2_k127_1028521_1 PFAM Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 589.0
HKD2_k127_1028521_2 Sigma-54-dependent sensor transcriptional response regulator, PAS domain-containing K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 527.0
HKD2_k127_1028521_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008706 473.0
HKD2_k127_1028521_4 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 323.0
HKD2_k127_1028521_5 Class III cytochrome C family - - - 0.000000000000000000000000000000000000000002305 163.0
HKD2_k127_1028521_6 PhoQ Sensor - - - 0.00000000000000000002832 98.0
HKD2_k127_1030540_0 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007558 359.0
HKD2_k127_1030540_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000002391 233.0
HKD2_k127_1030540_2 Peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000001084 186.0
HKD2_k127_1030540_3 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000000002992 129.0
HKD2_k127_1030540_4 auxin-activated signaling pathway K07088 - - 0.000000000000000004762 87.0
HKD2_k127_1047305_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 525.0
HKD2_k127_1047305_1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.0000000000000000000000000000000000000000000000000000000006416 213.0
HKD2_k127_1051360_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.0 1068.0
HKD2_k127_1051360_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 5.284e-276 854.0
HKD2_k127_1051360_2 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 471.0
HKD2_k127_1051360_3 Belongs to the arginase family K01476,K01480 - 3.5.3.1,3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009164 397.0
HKD2_k127_1051360_4 PFAM phosphoesterase RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 378.0
HKD2_k127_1051360_5 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008501 302.0
HKD2_k127_1051360_6 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000003139 269.0
HKD2_k127_1051360_7 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000000000162 221.0
HKD2_k127_1051360_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000006295 149.0
HKD2_k127_1051360_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000004106 134.0
HKD2_k127_1063888_0 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007489 403.0
HKD2_k127_1063888_1 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 341.0
HKD2_k127_1063888_2 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000004615 84.0
HKD2_k127_1063888_3 NMT1/THI5 like K02051 - - 0.0000001996 53.0
HKD2_k127_1089211_0 TIGRFAM alpha-glucan K00688 - 2.4.1.1 2.662e-300 936.0
HKD2_k127_1089211_1 Radical SAM superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 555.0
HKD2_k127_1089211_10 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000472 228.0
HKD2_k127_1089211_11 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000003158 219.0
HKD2_k127_1089211_12 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000000000000002287 203.0
HKD2_k127_1089211_13 - - - - 0.0000000000000000000000000000000000000000000000000000005577 196.0
HKD2_k127_1089211_14 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000000000000000000000000000000000006638 166.0
HKD2_k127_1089211_15 Belongs to the UPF0296 family K09777 - - 0.0000000000000000000000000000000000001788 143.0
HKD2_k127_1089211_16 PFAM Outer membrane K06142 - - 0.00000000000000000000000001641 117.0
HKD2_k127_1089211_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 556.0
HKD2_k127_1089211_3 PFAM RNA binding S1 domain protein K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 498.0
HKD2_k127_1089211_4 Bifunctional protein K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 439.0
HKD2_k127_1089211_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 383.0
HKD2_k127_1089211_6 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 332.0
HKD2_k127_1089211_7 Domain of unknown function (DUF3786) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003718 261.0
HKD2_k127_1089211_8 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000003942 259.0
HKD2_k127_1089211_9 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000000000000000000000000000000000000000000000000003943 227.0
HKD2_k127_111108_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 4.586e-249 784.0
HKD2_k127_111108_1 TIGRFAM molybdenum cofactor synthesis domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 492.0
HKD2_k127_111108_2 - - - - 0.000000000000000000000000000000000000000000000006811 175.0
HKD2_k127_111108_4 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000001063 125.0
HKD2_k127_111108_5 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000285 105.0
HKD2_k127_111108_6 - - - - 0.000000000003478 74.0
HKD2_k127_1125233_0 PFAM aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 597.0
HKD2_k127_1125233_1 SCP-2 sterol transfer family - - - 0.00000000000000000000000004587 112.0
HKD2_k127_1228986_0 Beta-L-arabinofuranosidase, GH127 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 595.0
HKD2_k127_1228986_1 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 447.0
HKD2_k127_1228986_2 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 335.0
HKD2_k127_1228986_3 Adenylosuccinate lyase C-terminus K01756,K01857 - 4.3.2.2,5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 320.0
HKD2_k127_1228986_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007219 313.0
HKD2_k127_1228986_5 HupE / UreJ protein K03192 - - 0.000000000000000000000000000000000000000000000000001219 189.0
HKD2_k127_1228986_6 Belongs to the NiCoT transporter (TC 2.A.52) family K08970 - - 0.0000000000000000000000000000000000001034 154.0
HKD2_k127_1228986_8 Tetratricopeptide repeat - - - 0.000000005776 64.0
HKD2_k127_1234825_0 AcrB/AcrD/AcrF family K03296,K19594 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 411.0
HKD2_k127_1234825_1 AcrB/AcrD/AcrF family K03296,K19594 - - 0.00000000000000000000000000000000000000000000000000000000000000000002182 235.0
HKD2_k127_1234825_2 Biotin-lipoyl like K19595 - - 0.00000000000000000000000199 105.0
HKD2_k127_1252926_0 PFAM Outer membrane efflux protein K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 570.0
HKD2_k127_1252926_1 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 361.0
HKD2_k127_1252926_2 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000101 92.0
HKD2_k127_1252926_3 Sulfatase - - - 0.0000000000000131 78.0
HKD2_k127_125330_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.0 1967.0
HKD2_k127_125330_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 9.69e-231 721.0
HKD2_k127_125330_10 HlyD membrane-fusion protein of T1SS K03543 - - 0.000000000000000000000000000000000000000000000000000000000009863 216.0
HKD2_k127_125330_11 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000001401 177.0
HKD2_k127_125330_12 - - - - 0.00000000000000000000000002545 113.0
HKD2_k127_125330_13 S4 domain K14761 - - 0.0000000000000001359 84.0
HKD2_k127_125330_14 ATP-independent chaperone mediated protein folding - - - 0.0000000000001817 79.0
HKD2_k127_125330_15 COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases K01153 - 3.1.21.3 0.0005123 43.0
HKD2_k127_125330_2 PFAM natural resistance-associated macrophage protein K03322 - - 1.019e-198 627.0
HKD2_k127_125330_3 Major Facilitator Superfamily K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 572.0
HKD2_k127_125330_4 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 348.0
HKD2_k127_125330_5 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 342.0
HKD2_k127_125330_6 May be involved in recombination - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006578 269.0
HKD2_k127_125330_7 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008537 249.0
HKD2_k127_125330_8 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000000000004949 239.0
HKD2_k127_125330_9 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000002425 219.0
HKD2_k127_1274447_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1071.0
HKD2_k127_1274447_1 signal peptide processing - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 430.0
HKD2_k127_1274447_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000009812 197.0
HKD2_k127_1274447_3 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000006963 55.0
HKD2_k127_1285249_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 515.0
HKD2_k127_1285249_1 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007007 310.0
HKD2_k127_1285249_2 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 306.0
HKD2_k127_1285249_3 SMART Rhodanese domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000002202 220.0
HKD2_k127_1285249_4 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000001331 125.0
HKD2_k127_1285249_5 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.00000000000000000000000000001806 127.0
HKD2_k127_1285249_6 PFAM Type IV pilus assembly PilZ - - - 0.0000000000000000000004403 100.0
HKD2_k127_1285249_7 PFAM Late competence development protein ComFB - - - 0.0000000000000000005219 91.0
HKD2_k127_1285249_8 PFAM CheW domain protein K03408 - - 0.00000000000000006643 82.0
HKD2_k127_1285249_9 methyl-accepting chemotaxis protein K03406 - - 0.0001007 50.0
HKD2_k127_1286604_0 PFAM Hemerythrin HHE cation binding domain K09155 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 408.0
HKD2_k127_1286604_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0000000000000000000000000000000000000000000000000000000003768 210.0
HKD2_k127_1286604_2 Pro-kumamolisin, activation domain - - - 0.00000000000000000001747 100.0
HKD2_k127_1297563_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 1.261e-213 678.0
HKD2_k127_1297563_1 Bacterial regulatory protein, Fis family K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 558.0
HKD2_k127_1297563_10 PFAM Dinitrogenase iron-molybdenum cofactor - - - 0.000000000000000000071 94.0
HKD2_k127_1297563_2 NAD(P)H-binding K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 511.0
HKD2_k127_1297563_3 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 460.0
HKD2_k127_1297563_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005609 355.0
HKD2_k127_1297563_5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007402 338.0
HKD2_k127_1297563_6 Putative transmembrane protein (Alph_Pro_TM) - - - 0.0000000000000000000000000000000000000000002539 169.0
HKD2_k127_1297563_7 part of a sulfur-relay system - - - 0.0000000000000000000000000000008348 124.0
HKD2_k127_1297563_8 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000009749 123.0
HKD2_k127_1297563_9 Protein of unknown function DUF134 - - - 0.00000000000000000000000000008768 118.0
HKD2_k127_1332049_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007036 559.0
HKD2_k127_1332049_1 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000166 265.0
HKD2_k127_1332049_2 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000003394 149.0
HKD2_k127_1360609_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0 1170.0
HKD2_k127_1360609_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000001485 188.0
HKD2_k127_1394655_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 1.63e-300 932.0
HKD2_k127_1394655_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 6.777e-236 734.0
HKD2_k127_1394655_10 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 300.0
HKD2_k127_1394655_11 PFAM ABC transporter K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003172 255.0
HKD2_k127_1394655_12 PFAM amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000004989 219.0
HKD2_k127_1394655_13 PFAM Curli production assembly transport component CsgG - - - 0.000000000000000000000000000000000000000000000000001035 205.0
HKD2_k127_1394655_14 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000005432 179.0
HKD2_k127_1394655_15 - - - - 0.00000000000000000000000000000000004575 140.0
HKD2_k127_1394655_16 - - - - 0.000004853 51.0
HKD2_k127_1394655_2 PFAM ABC transporter K06158 - - 2.944e-200 631.0
HKD2_k127_1394655_3 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 497.0
HKD2_k127_1394655_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 471.0
HKD2_k127_1394655_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 439.0
HKD2_k127_1394655_6 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 358.0
HKD2_k127_1394655_7 Radical_SAM C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 335.0
HKD2_k127_1394655_8 GHKL domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008615 329.0
HKD2_k127_1394655_9 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 314.0
HKD2_k127_1445231_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 5.716e-199 632.0
HKD2_k127_1445231_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 496.0
HKD2_k127_1445231_10 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000004317 111.0
HKD2_k127_1445231_11 general secretion pathway protein - - - 0.000001127 59.0
HKD2_k127_1445231_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007282 488.0
HKD2_k127_1445231_3 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008784 357.0
HKD2_k127_1445231_4 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 316.0
HKD2_k127_1445231_5 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001128 280.0
HKD2_k127_1445231_6 general secretion pathway protein G K02456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001754 246.0
HKD2_k127_1445231_7 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000006295 232.0
HKD2_k127_1445231_8 general secretion pathway protein K02457,K02458,K10926,K10930,K10931 GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840 - 0.00000000000000000000000000000000000000000002649 179.0
HKD2_k127_1445231_9 Pentapeptide repeats (8 copies) - - - 0.000000000000000000000000000000000000000001966 172.0
HKD2_k127_1449517_0 cysteinyl-tRNA synthetase K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.0 1167.0
HKD2_k127_1449517_1 LapD/MoxY periplasmic domain - - - 9.131e-196 625.0
HKD2_k127_1449517_2 PFAM Outer membrane efflux protein K12543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 450.0
HKD2_k127_1449517_3 PFAM transglutaminase family protein cysteine peptidase BTLCP - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001411 274.0
HKD2_k127_1449517_4 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.000000000000000001552 93.0
HKD2_k127_1455423_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 611.0
HKD2_k127_1455423_1 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 323.0
HKD2_k127_1455423_2 sigma-70 region 2 domain protein K03088 - - 0.0000000000209 65.0
HKD2_k127_1455423_3 AntiSigma factor - - - 0.000000003604 68.0
HKD2_k127_1455423_4 PFAM Pyrrolo-quinoline quinone - - - 0.0000002518 54.0
HKD2_k127_1491664_0 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 456.0
HKD2_k127_1491664_1 PFAM PhoH-like protein K07175 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 346.0
HKD2_k127_1491664_2 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 311.0
HKD2_k127_1491664_3 - - - - 0.00000000000000000000000000000000000000000001854 168.0
HKD2_k127_1501390_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006638 382.0
HKD2_k127_1501390_1 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000001198 78.0
HKD2_k127_1501390_2 domain, Protein - - - 0.0000000001227 72.0
HKD2_k127_1504691_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 5.78e-312 962.0
HKD2_k127_1504691_1 ATP-dependent Clp protease ATP-binding subunit ClpA K03694 - - 2.71e-309 964.0
HKD2_k127_1504691_10 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 317.0
HKD2_k127_1504691_11 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002072 250.0
HKD2_k127_1504691_12 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000000001506 155.0
HKD2_k127_1504691_13 lyase activity - - - 0.000000000000000000003297 96.0
HKD2_k127_1504691_14 heavy metal transport detoxification protein K07213,K08364 - - 0.000000000000007306 78.0
HKD2_k127_1504691_3 Protein of unknown function (DUF3373) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 555.0
HKD2_k127_1504691_4 TIGRFAM histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 539.0
HKD2_k127_1504691_5 PFAM 2-nitropropane dioxygenase NPD K00459,K02371 - 1.13.12.16,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 479.0
HKD2_k127_1504691_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008544 475.0
HKD2_k127_1504691_7 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000451 460.0
HKD2_k127_1504691_8 Esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 469.0
HKD2_k127_1504691_9 DNA polymerase III, delta' K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 422.0
HKD2_k127_1535038_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.141e-234 740.0
HKD2_k127_1536050_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 446.0
HKD2_k127_1536050_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000002875 173.0
HKD2_k127_1536050_2 response regulator - - - 0.0000000000000000000000000000002327 128.0
HKD2_k127_1536050_3 Dinitrogenase iron-molybdenum cofactor - - - 0.000000000000000000000411 99.0
HKD2_k127_1536050_4 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0001086 51.0
HKD2_k127_1536453_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 620.0
HKD2_k127_1536453_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840,K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 580.0
HKD2_k127_1536453_10 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000263 155.0
HKD2_k127_1536453_11 - - - - 0.00000000000000000000000000000000001744 155.0
HKD2_k127_1536453_12 PilZ domain - - - 0.00000000000000000000000000000000004305 138.0
HKD2_k127_1536453_13 - - - - 0.00000000000000000000000000000324 128.0
HKD2_k127_1536453_14 polyketide synthase - - - 0.000001808 58.0
HKD2_k127_1536453_2 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 505.0
HKD2_k127_1536453_3 cytochrome C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 392.0
HKD2_k127_1536453_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 339.0
HKD2_k127_1536453_5 PFAM ApbE family K09740 - - 0.000000000000000000000000000000000000000000000000000000000000000000000317 246.0
HKD2_k127_1536453_6 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000003679 213.0
HKD2_k127_1536453_7 Glycosyl transferase family 2 K09931 - - 0.000000000000000000000000000000000000000000000001643 181.0
HKD2_k127_1536453_8 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000000000000000000001956 171.0
HKD2_k127_1536453_9 Colicin V production protein K03558 - - 0.0000000000000000000000000000000000000000368 160.0
HKD2_k127_1549657_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003831 537.0
HKD2_k127_1549657_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 341.0
HKD2_k127_1549657_2 Acid phosphatase homologues - - - 0.0000000000000000000000000000000004061 138.0
HKD2_k127_155563_0 plastoquinone (complex I) K05568,K12137 - - 1.633e-295 916.0
HKD2_k127_155563_1 Proton-conducting membrane transporter K05568 - - 7.292e-267 827.0
HKD2_k127_155563_2 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 5.804e-216 681.0
HKD2_k127_155563_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 580.0
HKD2_k127_155563_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 535.0
HKD2_k127_155563_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000007509 224.0
HKD2_k127_155563_6 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000005434 205.0
HKD2_k127_155563_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.00000000000000000000000000000000000000006598 164.0
HKD2_k127_1580331_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 7.786e-216 672.0
HKD2_k127_1580331_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 585.0
HKD2_k127_1580331_2 Tetracycline repressor, C-terminal all-alpha domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000009566 233.0
HKD2_k127_1586454_0 PFAM malic K00027,K00029 - 1.1.1.38,1.1.1.40 9.711e-271 846.0
HKD2_k127_1586454_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 503.0
HKD2_k127_1586454_10 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.000000000000000000000000000000000000000000000000000000001106 208.0
HKD2_k127_1586454_11 PFAM NosL family protein - - - 0.000000000000000000000000000000000000000005709 165.0
HKD2_k127_1586454_12 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000001847 149.0
HKD2_k127_1586454_13 - - - - 0.000000000000000000001091 102.0
HKD2_k127_1586454_14 Histidine kinase K15011 - 2.7.13.3 0.0000000000000000001871 89.0
HKD2_k127_1586454_2 FtsX-like permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 473.0
HKD2_k127_1586454_3 TIGRFAM lysine 2,3-aminomutase YodO family protein K01843 - 5.4.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 462.0
HKD2_k127_1586454_4 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008145 442.0
HKD2_k127_1586454_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 333.0
HKD2_k127_1586454_6 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007006 318.0
HKD2_k127_1586454_7 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002192 282.0
HKD2_k127_1586454_9 response regulator K15012 - - 0.000000000000000000000000000000000000000000000000000000000000000006691 229.0
HKD2_k127_1590340_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1088.0
HKD2_k127_1590340_1 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 382.0
HKD2_k127_1590340_2 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 325.0
HKD2_k127_1590340_3 Belongs to the ompA family - - - 0.0000000000000000001368 98.0
HKD2_k127_1595034_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 7.951e-244 757.0
HKD2_k127_1595034_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 2.5e-217 678.0
HKD2_k127_1595034_2 G-rich domain on putative tyrosine kinase K16554 - - 3.368e-201 650.0
HKD2_k127_1595034_3 Homocysteine S-methyltransferase K00297,K00547,K00548 - 1.5.1.20,2.1.1.10,2.1.1.13 5.645e-198 632.0
HKD2_k127_1595034_4 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 584.0
HKD2_k127_1595034_5 Lipid A core-O-antigen ligase-like enyme K18814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009145 525.0
HKD2_k127_1595034_6 3D domain protein K21471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001835 262.0
HKD2_k127_1595034_7 export protein K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005323 257.0
HKD2_k127_1595034_8 PFAM PHP domain protein K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000001559 193.0
HKD2_k127_1602305_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 2.537e-287 897.0
HKD2_k127_1602305_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 3.781e-205 651.0
HKD2_k127_1602305_10 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000000000000000000001452 228.0
HKD2_k127_1602305_11 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000004817 145.0
HKD2_k127_1602305_12 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000001213 128.0
HKD2_k127_1602305_13 ribonuclease P activity K03536,K08998 GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.000000000000000000000000009699 113.0
HKD2_k127_1602305_14 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000001584 109.0
HKD2_k127_1602305_15 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000000547 75.0
HKD2_k127_1602305_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 510.0
HKD2_k127_1602305_3 Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs K15257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 428.0
HKD2_k127_1602305_4 ligase activity, forming carbon-carbon bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 328.0
HKD2_k127_1602305_5 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004543 314.0
HKD2_k127_1602305_6 Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) K15256 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 290.0
HKD2_k127_1602305_7 PFAM single-stranded nucleic acid binding R3H K06346 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000312 270.0
HKD2_k127_1602305_8 biotin-[acetyl-CoA-carboxylase] ligase activity K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000001126 261.0
HKD2_k127_1602305_9 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002781 245.0
HKD2_k127_1606267_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1401.0
HKD2_k127_1606267_1 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 436.0
HKD2_k127_1606267_10 Belongs to the UPF0434 family K09791 - - 0.000000000000000000006408 94.0
HKD2_k127_1606267_2 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 420.0
HKD2_k127_1606267_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 373.0
HKD2_k127_1606267_4 Oxygen tolerance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 354.0
HKD2_k127_1606267_5 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 331.0
HKD2_k127_1606267_6 general secretion pathway protein K02457,K02458,K10926,K10930,K10931 GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001024 286.0
HKD2_k127_1606267_7 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000001273 235.0
HKD2_k127_1606267_8 Domain of unknown function (DUF4381) - - - 0.0000000000000000000000000001361 123.0
HKD2_k127_1606267_9 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000001493 121.0
HKD2_k127_1631078_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 2.21e-236 737.0
HKD2_k127_1631078_1 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K11779,K11784,K18285 - 1.21.98.1,2.5.1.120,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 599.0
HKD2_k127_1631078_2 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 576.0
HKD2_k127_1631078_3 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 546.0
HKD2_k127_1631078_4 Amidohydrolase family K20810 - 3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 336.0
HKD2_k127_1631078_5 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000002653 201.0
HKD2_k127_1631078_6 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000000000000000000000000000000000000000002096 168.0
HKD2_k127_1631078_7 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000000002216 162.0
HKD2_k127_1631078_8 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0001125 48.0
HKD2_k127_1668799_0 HELICc2 K03722 - 3.6.4.12 8.114e-248 782.0
HKD2_k127_1668799_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 306.0
HKD2_k127_1668799_2 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009781 298.0
HKD2_k127_1668799_3 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004701 254.0
HKD2_k127_1668799_4 Divergent polysaccharide deacetylase K09798 - - 0.00000000000000000000000000000000000000000000000000000000000000002627 238.0
HKD2_k127_1671110_0 TIGRFAM potassium uptake protein, TrkH family K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 573.0
HKD2_k127_1671110_1 PFAM TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 314.0
HKD2_k127_1671110_2 - - - - 0.00000000000000000000000000000000000000000000002255 179.0
HKD2_k127_1682125_0 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 490.0
HKD2_k127_1682125_1 TIGRFAM peptidase T-like protein K01258 - 3.4.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 471.0
HKD2_k127_1682125_2 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 385.0
HKD2_k127_1682125_3 Transporter associated domain K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007099 341.0
HKD2_k127_1682125_4 - - - - 0.00000002482 61.0
HKD2_k127_1682125_5 Ribonuclease H K03469 - 3.1.26.4 0.0001499 45.0
HKD2_k127_1709756_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 564.0
HKD2_k127_1709756_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07642 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002593 508.0
HKD2_k127_1709756_10 - - - - 0.000000000000001176 78.0
HKD2_k127_1709756_2 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 373.0
HKD2_k127_1709756_3 response regulator K07664 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 331.0
HKD2_k127_1709756_4 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 309.0
HKD2_k127_1709756_5 Radical SAM superfamily K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 289.0
HKD2_k127_1709756_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002239 234.0
HKD2_k127_1709756_7 synthase K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.0000000000000000000000000000000000000000000000008131 179.0
HKD2_k127_1709756_8 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000006509 172.0
HKD2_k127_1709756_9 - - - - 0.00000000000000000000000000002747 123.0
HKD2_k127_1725144_0 PFAM AICARFT IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 3.368e-233 727.0
HKD2_k127_1725144_1 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 1.249e-203 647.0
HKD2_k127_1725144_10 ThiS family K03154 - - 0.0000000001082 65.0
HKD2_k127_1725144_2 Biotin and Thiamin Synthesis associated K03150 - 4.1.99.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 512.0
HKD2_k127_1725144_3 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 382.0
HKD2_k127_1725144_4 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006207 362.0
HKD2_k127_1725144_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000083 345.0
HKD2_k127_1725144_6 PFAM inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000004711 249.0
HKD2_k127_1725144_7 transmembrane signaling receptor activity K02660,K03406,K03776,K11525 - - 0.0000000000000000000000000000000000000000000000000000000000000033 222.0
HKD2_k127_1725144_8 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000000000000002466 137.0
HKD2_k127_1725144_9 oligosaccharyl transferase activity - - - 0.0000000000000000000009899 103.0
HKD2_k127_1739113_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 444.0
HKD2_k127_1739113_1 Signal transduction histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 419.0
HKD2_k127_1745512_0 CHASE2 K01768 - 4.6.1.1 2.039e-202 650.0
HKD2_k127_1745512_1 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 336.0
HKD2_k127_1745512_2 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000983 228.0
HKD2_k127_1745512_3 Src homology 3 domains K01227,K01447,K01448,K06385,K07260,K11060,K11062,K21472 - 3.2.1.96,3.4.17.14,3.5.1.28 0.000000000000000000000000000000003465 132.0
HKD2_k127_179165_0 reductase, alpha subunit K00394 - 1.8.99.2 0.0 1295.0
HKD2_k127_179165_1 Methyl-viologen-reducing hydrogenase, delta subunit K16886 - - 2.084e-272 849.0
HKD2_k127_179165_2 FAD dependent oxidoreductase K16885 - - 7.548e-219 686.0
HKD2_k127_179165_3 reductase, beta subunit K00395 - 1.8.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009856 287.0
HKD2_k127_179165_4 DNA segregation ATPase, FtsK SpoIIIE family K03466 - - 0.0000000000008019 68.0
HKD2_k127_183959_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 8.714e-235 730.0
HKD2_k127_183959_1 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 431.0
HKD2_k127_183959_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 310.0
HKD2_k127_183959_3 PFAM transcription factor CarD K07736 - - 0.0000000000000000000000000000000000000000000000000000000000000000004532 239.0
HKD2_k127_183959_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000359 178.0
HKD2_k127_183959_5 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000000000000000001133 166.0
HKD2_k127_183959_6 Binds the 23S rRNA K02909 - - 0.00000000000000000000000000001822 118.0
HKD2_k127_1872027_0 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 534.0
HKD2_k127_1872027_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000002978 141.0
HKD2_k127_191085_0 type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 327.0
HKD2_k127_191085_1 General secretion pathway protein C K02452 - - 0.000000000000000000000004522 111.0
HKD2_k127_1920365_0 Conserved carboxylase domain K01958 - 6.4.1.1 5.041e-312 964.0
HKD2_k127_1920365_1 PFAM Carbamoyl-phosphate synthase L chain K01959,K01961 - 6.3.4.14,6.4.1.1,6.4.1.2 5.13e-235 734.0
HKD2_k127_1978161_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 1.753e-230 734.0
HKD2_k127_1978161_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 548.0
HKD2_k127_1978161_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00362 - 1.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005678 378.0
HKD2_k127_1978161_3 PFAM Cytochrome c assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003045 286.0
HKD2_k127_1978161_4 Lysine methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001133 269.0
HKD2_k127_1978161_5 TIGRFAM siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000000000000000001499 193.0
HKD2_k127_1978161_6 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000004953 169.0
HKD2_k127_1983347_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 4.246e-320 1035.0
HKD2_k127_1983347_1 PFAM CheR methyltransferase, SAM binding domain K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 336.0
HKD2_k127_1983347_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 329.0
HKD2_k127_1983347_3 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000006065 198.0
HKD2_k127_1983347_4 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000004889 187.0
HKD2_k127_1983347_5 methyltransferase activity - - - 0.00000000000000000000000000000000000008313 152.0
HKD2_k127_1983347_6 Diguanylate cyclase - - - 0.0000000000000000000000000000003386 141.0
HKD2_k127_1983347_7 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000005473 136.0
HKD2_k127_1983347_8 - - - - 0.0000000000000000000001826 103.0
HKD2_k127_1983347_9 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000002258 90.0
HKD2_k127_2061749_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.1.11.5 3.723e-242 789.0
HKD2_k127_2061749_1 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity K03583 - 3.1.11.5 7.653e-210 690.0
HKD2_k127_2061749_2 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD K03581 GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009338,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.1.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000001635 278.0
HKD2_k127_2061749_3 His Kinase A (phosphoacceptor) domain - - - 0.00000004615 65.0
HKD2_k127_2093469_0 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 407.0
HKD2_k127_2093469_1 Glycoside-hydrolase family GH114 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 363.0
HKD2_k127_2093469_2 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005027 330.0
HKD2_k127_2093469_3 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000003939 173.0
HKD2_k127_2093469_5 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000002136 158.0
HKD2_k127_2093469_6 organic phosphonate transport K02044 - - 0.0000000000000000000000665 106.0
HKD2_k127_2093469_7 SnoaL-like polyketide cyclase - - - 0.000000000000000001364 93.0
HKD2_k127_2093469_8 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000008667 93.0
HKD2_k127_2098106_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 413.0
HKD2_k127_2098106_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001197 229.0
HKD2_k127_2098106_2 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000002894 219.0
HKD2_k127_2098106_3 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.00000000000000000000000000000000000000000000000003805 186.0
HKD2_k127_2125488_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0 1189.0
HKD2_k127_2125488_1 Putative nucleotidyltransferase substrate binding domain K07182 - - 7.914e-292 906.0
HKD2_k127_2125488_10 Phosphopantetheine attachment site - - - 0.000000000000000000000000000000000000002394 148.0
HKD2_k127_2125488_2 Flavin containing amine oxidoreductase - - - 2.147e-231 727.0
HKD2_k127_2125488_3 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 4.418e-209 656.0
HKD2_k127_2125488_4 Flavin containing amine oxidoreductase K09835,K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,5.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 513.0
HKD2_k127_2125488_5 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 330.0
HKD2_k127_2125488_6 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 310.0
HKD2_k127_2125488_7 DNA polymerase III, epsilon subunit K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000007554 250.0
HKD2_k127_2125488_8 PFAM Isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000002217 199.0
HKD2_k127_2125488_9 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000006525 179.0
HKD2_k127_216905_0 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004938 318.0
HKD2_k127_216905_2 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000003145 167.0
HKD2_k127_216905_3 Substrate binding domain of ABC-type glycine betaine transport system - - - 0.0000000000000000000000000000000425 133.0
HKD2_k127_216905_4 alginic acid biosynthetic process - - - 0.0000000000000000000000000000001526 136.0
HKD2_k127_2174050_0 GXGXG motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 399.0
HKD2_k127_2174050_1 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 313.0
HKD2_k127_2214296_0 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 372.0
HKD2_k127_2214296_1 CHAD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 305.0
HKD2_k127_2214296_3 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000005625 186.0
HKD2_k127_2214296_4 Histidine phosphatase superfamily (branch 1) K08296 - - 0.000000000000000000000000000000000000000000006235 174.0
HKD2_k127_2214296_5 Rhodanese-like domain - - - 0.00000000000000000000001813 106.0
HKD2_k127_2214296_6 Histidine kinase - - - 0.000000000000000005008 85.0
HKD2_k127_2217770_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 9.8e-213 675.0
HKD2_k127_2218851_0 alginic acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001088 273.0
HKD2_k127_2218851_1 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000001703 247.0
HKD2_k127_2218851_2 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000004863 232.0
HKD2_k127_2218851_3 NHL repeat - - - 0.0000000000000000000001209 115.0
HKD2_k127_2218851_4 domain protein - - - 0.00000002533 65.0
HKD2_k127_2218851_5 Sulfatase K01130 - 3.1.6.1 0.00006608 51.0
HKD2_k127_2239467_0 signal-transduction protein with CBS domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008285 340.0
HKD2_k127_2239467_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000004191 190.0
HKD2_k127_2239467_2 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000005323 134.0
HKD2_k127_2239467_3 lipopolysaccharide biosynthesis protein - - - 0.00006125 48.0
HKD2_k127_2240832_0 dTDP-4-dehydrorhamnose reductase activity K00067,K19997 - 1.1.1.133,5.1.3.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 533.0
HKD2_k127_2240832_1 ThiF family K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 353.0
HKD2_k127_2240832_2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.00000000000000000000000000000000000000000000000000000004315 207.0
HKD2_k127_2240832_3 triose-phosphate isomerase activity K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000006436 192.0
HKD2_k127_2240832_4 YMGG-like Gly-zipper - - - 0.0000000000000000000000000000000000000002953 155.0
HKD2_k127_2240832_5 - - - - 0.000000000000000000000000000004134 126.0
HKD2_k127_2248673_1 PFAM peptidase M3A and M3B, thimet oligopeptidase F K08602 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 384.0
HKD2_k127_2248673_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 354.0
HKD2_k127_2248673_3 Metalloenzyme superfamily - - - 0.00000000000000000000000000000000000000000000006218 182.0
HKD2_k127_2248673_4 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000002336 163.0
HKD2_k127_2248673_5 Putative TM nitroreductase - - - 0.0000000000000000000000000000000000000002844 154.0
HKD2_k127_2248673_6 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000004388 135.0
HKD2_k127_2248673_7 Cyclic-di-AMP receptor - - - 0.0000000000000000000000000000003097 125.0
HKD2_k127_2248673_8 Cyclic-di-AMP receptor - - - 0.0000000000000000000000003863 106.0
HKD2_k127_2249821_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0 1114.0
HKD2_k127_2249821_1 PFAM Transketolase K00615 - 2.2.1.1 4.646e-255 803.0
HKD2_k127_2249821_10 Belongs to the 'phage' integrase family - - - 0.000000000000001032 83.0
HKD2_k127_2249821_2 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 1.537e-234 760.0
HKD2_k127_2249821_3 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00334,K00335,K18331 - 1.12.1.3,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 611.0
HKD2_k127_2249821_4 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 524.0
HKD2_k127_2249821_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 400.0
HKD2_k127_2249821_6 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 346.0
HKD2_k127_2249821_7 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 322.0
HKD2_k127_2249821_8 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000327 232.0
HKD2_k127_2249821_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.00000000000000000000000000000000000000000000000002672 185.0
HKD2_k127_2258203_0 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003459 264.0
HKD2_k127_2258203_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002716 263.0
HKD2_k127_2258203_2 protein trimerization K07114,K08309 - - 0.00000000000000000000000000000000000000000000000000004655 201.0
HKD2_k127_2258203_3 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.000000000000000000000000000000000000004298 147.0
HKD2_k127_2265456_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007626 546.0
HKD2_k127_2265456_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 457.0
HKD2_k127_2265456_2 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000001079 216.0
HKD2_k127_2265456_3 Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000001252 194.0
HKD2_k127_2287074_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1373.0
HKD2_k127_2287074_1 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000007703 215.0
HKD2_k127_2287074_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000001804 120.0
HKD2_k127_2287074_3 ribonucleoside-diphosphate reductase activity K00525,K00526 - 1.17.4.1 0.00000000000007507 79.0
HKD2_k127_2288576_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1264.0
HKD2_k127_2288576_1 Calcineurin-like phosphoesterase K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 608.0
HKD2_k127_2288576_2 AAA domain K03546 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 525.0
HKD2_k127_2288576_3 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 407.0
HKD2_k127_2288576_4 4Fe-4S dicluster domain K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 314.0
HKD2_k127_2288576_5 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000141 267.0
HKD2_k127_2288576_6 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000003582 161.0
HKD2_k127_2288576_7 Prokaryotic cytochrome b561 K00127 - - 0.000000000000000000000000000000002155 137.0
HKD2_k127_2288576_8 ferric iron binding K02380 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0051604,GO:0055114,GO:0071704,GO:1901564 - 0.00000000000000000000000001267 122.0
HKD2_k127_2309731_0 - - - - 3.486e-206 659.0
HKD2_k127_2309731_1 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 499.0
HKD2_k127_2309731_2 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 464.0
HKD2_k127_2309731_3 Magnesium transport protein CorA K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 411.0
HKD2_k127_2309731_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 391.0
HKD2_k127_2309731_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007092 272.0
HKD2_k127_2309731_6 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000196 248.0
HKD2_k127_2309731_7 - - - - 0.0000000000000000000000000000000000000000000000000129 184.0
HKD2_k127_2309731_8 PFAM pyridoxamine 5-phosphate - - - 0.000000000000000000000000000000000000001201 151.0
HKD2_k127_2329632_0 GDP-mannose 4,6 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 604.0
HKD2_k127_2329632_1 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000005838 212.0
HKD2_k127_2329632_2 23S rRNA-intervening sequence protein - - - 0.0000000000000000000000000000000000000000005108 160.0
HKD2_k127_2329632_3 a CheY-like receiver domain and an HD-GYP domain K07814,K13815 - - 0.0000000000000000001487 99.0
HKD2_k127_2341675_0 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 515.0
HKD2_k127_2341675_1 PFAM ABC transporter related K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 383.0
HKD2_k127_2341675_10 PilZ domain - - - 0.00000000000009449 76.0
HKD2_k127_2341675_11 Putative zinc- or iron-chelating domain K06940 - - 0.00000001941 61.0
HKD2_k127_2341675_2 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 383.0
HKD2_k127_2341675_3 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 382.0
HKD2_k127_2341675_4 Flavin reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 301.0
HKD2_k127_2341675_5 FmdE, Molybdenum formylmethanofuran dehydrogenase operon K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000001938 224.0
HKD2_k127_2341675_6 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000209 216.0
HKD2_k127_2341675_7 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.0000000000000000000000000000000000000000000002735 172.0
HKD2_k127_2341675_8 Flavin reductase - - - 0.000000000000000000000000000000003868 133.0
HKD2_k127_2341755_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 329.0
HKD2_k127_2341755_1 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000001015 206.0
HKD2_k127_2341755_2 Ribosomal protein L11 methyltransferase (PrmA) K05929 - 2.1.1.103 0.0000000000000000000000000000000000000000005155 166.0
HKD2_k127_2341755_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000101 145.0
HKD2_k127_2341755_4 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000007899 141.0
HKD2_k127_2360312_0 Large extracellular alpha-helical protein K06894 - - 1.467e-247 825.0
HKD2_k127_2360312_1 Sigma-54 interaction domain K07714,K07715 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 610.0
HKD2_k127_2360312_10 Putative metal-binding motif - - - 0.000000000000000000000000000002774 136.0
HKD2_k127_2360312_11 TIGRFAM Cytochrome o ubiquinol oxidase subunit IV K02300 - - 0.00000000000000000000001456 103.0
HKD2_k127_2360312_12 cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.0000000000003085 69.0
HKD2_k127_2360312_2 penicillin binding K05367 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 579.0
HKD2_k127_2360312_3 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 499.0
HKD2_k127_2360312_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 484.0
HKD2_k127_2360312_5 3-dehydroquinate synthase K01735,K19969 - 4.2.3.152,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 430.0
HKD2_k127_2360312_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 317.0
HKD2_k127_2360312_7 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 295.0
HKD2_k127_2360312_8 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001754 283.0
HKD2_k127_2362911_0 DNA polymerase K02337,K14162 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 397.0
HKD2_k127_237361_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1620.0
HKD2_k127_237361_1 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 5.013e-213 667.0
HKD2_k127_237361_2 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.000000000000000000000000000000009811 128.0
HKD2_k127_2390156_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 421.0
HKD2_k127_2390156_1 - - - - 0.00000000000000000000000000000000000000000000000000002727 200.0
HKD2_k127_2390156_2 - - - - 0.000000000000000000000000000000000000000000000001585 183.0
HKD2_k127_2390156_3 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000000000001664 138.0
HKD2_k127_2427556_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1564.0
HKD2_k127_2427556_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 406.0
HKD2_k127_2427556_10 PFAM Glycoside hydrolase, family 13 - - - 0.0000000000000000000000000000000004242 134.0
HKD2_k127_2427556_11 regulatory protein, FmdB family - - - 0.0000000000000000000000001887 108.0
HKD2_k127_2427556_13 Amb_all K01728 - 4.2.2.2 0.00000425 60.0
HKD2_k127_2427556_2 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 330.0
HKD2_k127_2427556_3 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 312.0
HKD2_k127_2427556_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 300.0
HKD2_k127_2427556_5 molybdenum cofactor guanylyltransferase activity K03637,K03752,K13818 - 2.7.7.77,4.6.1.17 0.000000000000000000000000000000000000000000000000000000004906 206.0
HKD2_k127_2427556_6 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000000000528 200.0
HKD2_k127_2427556_7 Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11783 - 3.2.2.26 0.0000000000000000000000000000000000000000000000000000005298 200.0
HKD2_k127_2427556_8 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000008089 186.0
HKD2_k127_2427556_9 domain protein K20276 - - 0.00000000000000000000000000000000000000000000003247 194.0
HKD2_k127_2431653_0 Homocysteine biosynthesis enzyme, sulfur-incorporation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 617.0
HKD2_k127_2431653_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 385.0
HKD2_k127_2431653_2 PFAM Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002901 279.0
HKD2_k127_2431653_3 PFAM asparagine synthase K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000002517 239.0
HKD2_k127_2431653_4 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000000008956 143.0
HKD2_k127_247194_0 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000226 244.0
HKD2_k127_247194_1 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000000000000000000000008485 227.0
HKD2_k127_247194_2 PFAM Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.0000000000000000000000000000000000000000000000000000008576 194.0
HKD2_k127_247194_3 Ligated ion channel L-glutamate- and glycine-binding site K02030 - - 0.000000000000008843 80.0
HKD2_k127_2504638_0 non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005027 280.0
HKD2_k127_2504638_2 ABC-type transport system involved in lipoprotein release permease component - - - 0.000000000000000000000002314 104.0
HKD2_k127_2512502_0 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 380.0
HKD2_k127_2512502_1 dihydrofolate reductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 349.0
HKD2_k127_2512502_2 TonB dependent receptor K16092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 338.0
HKD2_k127_2512502_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000005205 236.0
HKD2_k127_2512502_4 response to abiotic stimulus K01971,K03086,K06867,K06886 GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006996,GO:0007010,GO:0007015,GO:0008092,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030029,GO:0030036,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044877,GO:0046983,GO:0051015,GO:0051259,GO:0065003,GO:0071840,GO:0097435 6.5.1.1 0.0000000000000000000000000000000000000247 147.0
HKD2_k127_251704_0 PFAM nickel-dependent hydrogenase large subunit K00436,K14126 - 1.12.1.2,1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 568.0
HKD2_k127_251704_1 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 449.0
HKD2_k127_251704_2 NADH ubiquinone oxidoreductase 20 kDa subunit K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 391.0
HKD2_k127_251704_3 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005644 248.0
HKD2_k127_2519355_0 chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006259 579.0
HKD2_k127_2519355_1 ATP-independent chaperone mediated protein folding K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 508.0
HKD2_k127_2519355_10 - - - - 0.0003183 51.0
HKD2_k127_2519355_2 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 452.0
HKD2_k127_2519355_3 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006772 320.0
HKD2_k127_2519355_4 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 293.0
HKD2_k127_2519355_5 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000000000000002674 185.0
HKD2_k127_2519355_6 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000006754 163.0
HKD2_k127_2519355_7 DNA polymerase beta domain protein region - - - 0.00000000000000000205 91.0
HKD2_k127_2519355_8 - - - - 0.0000000006331 68.0
HKD2_k127_2519355_9 Protein of unknown function (DUF3592) - - - 0.0000001946 61.0
HKD2_k127_2542144_0 COG0798 Arsenite efflux pump ACR3 and related K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 456.0
HKD2_k127_2542144_1 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 288.0
HKD2_k127_2542144_2 Putative Fe-S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000001063 226.0
HKD2_k127_2542144_3 PFAM regulatory protein, ArsR K03892 - - 0.000000000000000000000000006335 117.0
HKD2_k127_2542707_0 PFAM Na Pi-cotransporter K03324 - - 6.716e-227 720.0
HKD2_k127_2542707_1 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 563.0
HKD2_k127_2542707_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 402.0
HKD2_k127_2542707_3 CO dehydrogenase acetyl-CoA synthase gamma subunit (Corrinoid Fe-S protein) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001049 247.0
HKD2_k127_2542707_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000001048 229.0
HKD2_k127_2542707_5 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.000000000000000000000000000000000000000000000003133 177.0
HKD2_k127_2542707_6 PFAM thioesterase superfamily protein - - - 0.000000000000000000000000000000000000000002075 158.0
HKD2_k127_2542707_7 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 - 2.4.2.1,2.4.2.2 0.000000000000000000000000000000000000000003278 164.0
HKD2_k127_2542707_8 Protein of unknown function (DUF559) K03427 - 2.1.1.72 0.0000000000000000000000000000000008739 133.0
HKD2_k127_2542707_9 - - - - 0.0000009008 53.0
HKD2_k127_2553575_0 Dehydratase family K01687 - 4.2.1.9 9.232e-307 950.0
HKD2_k127_2553575_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.202e-294 912.0
HKD2_k127_2553575_10 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000000000000000000000000002766 247.0
HKD2_k127_2553575_11 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000006722 223.0
HKD2_k127_2553575_12 lipopolysaccharide transmembrane transporter activity K09774,K11719 - - 0.00000000000000000000000000000000000000000000000000009794 196.0
HKD2_k127_2553575_13 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000002428 192.0
HKD2_k127_2553575_14 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000001168 179.0
HKD2_k127_2553575_15 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0000000000000000000000000000000000000000132 156.0
HKD2_k127_2553575_16 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000002201 156.0
HKD2_k127_2553575_17 Rhodanese Homology Domain - - - 0.0000000000000000000000000001887 117.0
HKD2_k127_2553575_18 Resolvase - - - 0.0000009381 53.0
HKD2_k127_2553575_2 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 3.453e-217 678.0
HKD2_k127_2553575_3 PFAM type II secretion system protein E K02669 - - 1.187e-198 625.0
HKD2_k127_2553575_4 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 595.0
HKD2_k127_2553575_5 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 399.0
HKD2_k127_2553575_6 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 367.0
HKD2_k127_2553575_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 365.0
HKD2_k127_2553575_8 Glutamine cyclotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002229 281.0
HKD2_k127_2553575_9 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002122 257.0
HKD2_k127_2559539_0 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 440.0
HKD2_k127_2559539_1 ATPases of PP-loop superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 302.0
HKD2_k127_2559539_2 - - - - 0.0000000000000000000000000000000000000000000000000003921 191.0
HKD2_k127_256512_0 Glycosyl transferase family 21 - - - 0.0 1161.0
HKD2_k127_256512_1 lytic transglycosylase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000315 303.0
HKD2_k127_2577398_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388,K16885,K16886 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1151.0
HKD2_k127_2577398_1 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 451.0
HKD2_k127_2577398_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001337 264.0
HKD2_k127_2577398_3 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002879 238.0
HKD2_k127_2577398_4 PFAM Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000392 163.0
HKD2_k127_2577398_5 - - - - 0.0000000001068 71.0
HKD2_k127_2580114_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 2.608e-249 777.0
HKD2_k127_2580114_1 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 614.0
HKD2_k127_2580114_2 PFAM ATP-binding region ATPase domain protein K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 324.0
HKD2_k127_2580114_3 NapC/NirT cytochrome c family, N-terminal region K15876 - - 0.000000000000000000000000000000000000000000000000000000000000291 214.0
HKD2_k127_2580114_4 - - - - 0.000000000000000000000000000000000000000000000003333 179.0
HKD2_k127_2580114_5 COG0791 Cell wall-associated hydrolases (invasion-associated proteins) K13694,K13695 - 3.4.17.13 0.000000000000000000000000000000000000000004162 159.0
HKD2_k127_2580114_6 - - - - 0.00000000006514 75.0
HKD2_k127_2592922_0 Selenocysteine-specific translation elongation factor K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 576.0
HKD2_k127_2598732_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 7.091e-236 734.0
HKD2_k127_2598732_1 Bacterial extracellular solute-binding proteins, family 5 Middle K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 607.0
HKD2_k127_2598732_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000236 251.0
HKD2_k127_2598732_3 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000244 187.0
HKD2_k127_2610734_0 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003433 283.0
HKD2_k127_2610734_1 Belongs to the MurCDEF family K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000926 258.0
HKD2_k127_2610734_2 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000001303 143.0
HKD2_k127_2610734_3 Histidine kinase K02486,K07677,K07679 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0009927,GO:0009987,GO:0010447,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 0.000000000000000002002 89.0
HKD2_k127_2610734_4 Protein of unknown function (DUF1104) - - - 0.0000000003016 65.0
HKD2_k127_2615144_0 Tripartite tricarboxylate transporter TctA family K07793 - - 5.324e-221 696.0
HKD2_k127_2615144_1 TIGRFAM conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009243 478.0
HKD2_k127_2615144_2 Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate) K19268 - 5.4.99.1 0.000000000000000000000000000000000000000000000000001549 186.0
HKD2_k127_2615144_3 Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate) K01846 - 5.4.99.1 0.000000000000000000000000000000000000000000000000002969 189.0
HKD2_k127_2615144_4 Tripartite tricarboxylate transporter TctB family K07794 - - 0.000007562 48.0
HKD2_k127_2617896_0 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 514.0
HKD2_k127_2617896_1 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007889 400.0
HKD2_k127_2617896_2 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 414.0
HKD2_k127_2617896_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000001442 173.0
HKD2_k127_2619615_0 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 1.037e-240 761.0
HKD2_k127_2619615_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 434.0
HKD2_k127_2619615_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 348.0
HKD2_k127_2619615_3 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 309.0
HKD2_k127_2619615_4 COG0463 Glycosyltransferases involved in cell wall biogenesis K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000001614 263.0
HKD2_k127_2619615_5 PFAM Lipid A Biosynthesis N-terminal - - - 0.0000000000000000000000000000000000005185 141.0
HKD2_k127_2619615_6 GHKL domain K07642 - 2.7.13.3 0.00000000000001308 78.0
HKD2_k127_2641917_0 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 480.0
HKD2_k127_2641917_1 Domain of unknown function (DUF362) - - - 0.000000000000000000000002083 105.0
HKD2_k127_2654385_0 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 8.759e-212 666.0
HKD2_k127_2654385_1 galactose-1-phosphate uridylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007629 564.0
HKD2_k127_2654385_2 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 399.0
HKD2_k127_2654385_3 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 320.0
HKD2_k127_2654385_4 PFAM Rhodanese domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001868 276.0
HKD2_k127_2654385_5 - - - - 0.0000000000000000007346 94.0
HKD2_k127_2667215_0 SNF2 family N-terminal domain - - - 0.0 1097.0
HKD2_k127_2667215_1 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 311.0
HKD2_k127_2683729_0 SMART PUA domain containing protein K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000003201 247.0
HKD2_k127_2687230_0 DEAD DEAH box helicase K06877 - - 0.0 1092.0
HKD2_k127_2687230_1 prephenate dehydrogenase K04517,K14187 - 1.3.1.12,5.4.99.5 8.677e-224 710.0
HKD2_k127_2687230_2 SH3 domain - - - 0.00000000000000000000000003579 109.0
HKD2_k127_2778773_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 2.407e-320 993.0
HKD2_k127_2778773_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 421.0
HKD2_k127_2778773_2 - - - - 0.0000000000000000000000000000000000000000000000000000006043 204.0
HKD2_k127_2778773_3 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000002158 138.0
HKD2_k127_2778773_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000001145 64.0
HKD2_k127_2789307_0 MBOAT, membrane-bound O-acyltransferase family K19294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 507.0
HKD2_k127_2789307_1 transcription factor binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 436.0
HKD2_k127_2789307_10 denitrification pathway - - - 0.0000000000000000000000000000004367 136.0
HKD2_k127_2789307_11 chemotaxis K03406 - - 0.000000000000000000000000005522 128.0
HKD2_k127_2789307_12 Bacterial extracellular solute-binding protein K05772 - - 0.000002814 55.0
HKD2_k127_2789307_2 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 355.0
HKD2_k127_2789307_3 PFAM binding-protein-dependent transport systems inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 311.0
HKD2_k127_2789307_4 ABC transporter K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000003427 267.0
HKD2_k127_2789307_5 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002863 256.0
HKD2_k127_2789307_6 cytochrome - - - 0.000000000000000000000000000000000000000000000000000000000000002735 224.0
HKD2_k127_2789307_7 General secretory system II protein E domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000001241 226.0
HKD2_k127_2789307_8 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.000000000000000000000000000000000000000000001093 186.0
HKD2_k127_2789307_9 PFAM Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.000000000000000000000000000000002829 135.0
HKD2_k127_2815907_0 aldolase class-II K01624 - 4.1.2.13 3.935e-204 646.0
HKD2_k127_2815907_1 sigma-54 factor interaction domain-containing protein K02667 - - 2.883e-201 640.0
HKD2_k127_2815907_2 PFAM NAD dependent epimerase dehydratase family K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 595.0
HKD2_k127_2815907_3 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000047 594.0
HKD2_k127_2815907_4 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 527.0
HKD2_k127_2815907_5 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 490.0
HKD2_k127_2815907_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003758 274.0
HKD2_k127_2815907_7 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000005767 235.0
HKD2_k127_2821107_0 Macrocin-O-methyltransferase (TylF) - - - 0.000000000000000000000000000000000000000000000000000000009736 209.0
HKD2_k127_2821107_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000001334 182.0
HKD2_k127_2821107_2 glycosyl transferase family 2 K20444 - - 0.000000000000000000000802 106.0
HKD2_k127_28268_0 von Willebrand factor type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000001865 244.0
HKD2_k127_28268_1 Histidine kinase K13587 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000006702 230.0
HKD2_k127_2829109_0 Lysylphosphatidylglycerol synthase TM region K07027,K14205 - 2.3.2.3 1.096e-303 952.0
HKD2_k127_2829109_1 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000001766 149.0
HKD2_k127_2829109_2 Bacterial virulence protein (VirJ) - - - 0.0000000000000000000000000000005087 124.0
HKD2_k127_2838679_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.0 1100.0
HKD2_k127_2838679_1 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 0.0 1072.0
HKD2_k127_2838679_2 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 6.198e-216 683.0
HKD2_k127_2838679_3 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 426.0
HKD2_k127_2838679_4 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 386.0
HKD2_k127_2838679_5 permease - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 365.0
HKD2_k127_2838679_6 N-terminal domain of galactosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 340.0
HKD2_k127_2838679_7 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K04488,K13819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002866 243.0
HKD2_k127_2838679_8 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.00000000000000000000000000000003388 128.0
HKD2_k127_2844045_0 H( )-stimulated, divalent metal cation uptake system K03322 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 312.0
HKD2_k127_2844045_1 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005504 265.0
HKD2_k127_2902337_0 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 479.0
HKD2_k127_2902337_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000001103 241.0
HKD2_k127_2902337_2 - - - - 0.000000000000000000000000000008882 124.0
HKD2_k127_2908025_0 Protein of unknown function DUF89 - - - 3.5e-222 702.0
HKD2_k127_2908025_1 Belongs to the DegT DnrJ EryC1 family K13010,K19715 - 2.6.1.102,2.6.1.109 1.37e-199 627.0
HKD2_k127_2908025_10 Phosphoglycerate mutase family K02226,K22306 - 3.1.3.73,3.1.3.85 0.0000000000000000000000000000000006371 140.0
HKD2_k127_2908025_2 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 494.0
HKD2_k127_2908025_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 436.0
HKD2_k127_2908025_4 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 299.0
HKD2_k127_2908025_5 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.000000000000000000000000000000000000000000000000000000000003412 213.0
HKD2_k127_2908025_6 Specifically methylates the guanosine in position 1516 of 16S rRNA K15984 - 2.1.1.242 0.0000000000000000000000000000000000000000000000000002388 194.0
HKD2_k127_2908025_7 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000000000000000006727 157.0
HKD2_k127_2908025_8 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000001026 156.0
HKD2_k127_2908025_9 Tetratricopeptide repeat-like domain - - - 0.000000000000000000000000000000000006867 145.0
HKD2_k127_2911464_0 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009944 468.0
HKD2_k127_2911464_1 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000002594 237.0
HKD2_k127_2911464_2 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000002248 188.0
HKD2_k127_2911464_3 - - - - 0.000000000000000000000000000000000000000000007471 181.0
HKD2_k127_291320_0 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 349.0
HKD2_k127_291320_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000005078 129.0
HKD2_k127_2921747_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 4.732e-217 681.0
HKD2_k127_2921747_1 lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 327.0
HKD2_k127_2921747_2 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 295.0
HKD2_k127_2921747_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000000000001773 258.0
HKD2_k127_2921747_4 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000008542 190.0
HKD2_k127_2921747_5 DNA segregation ATPase, FtsK SpoIIIE family K03466 - - 0.000000000000000000000000000000000000000000000001613 183.0
HKD2_k127_2921747_6 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000003827 172.0
HKD2_k127_2938556_0 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 332.0
HKD2_k127_2938556_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000001049 189.0
HKD2_k127_2938556_2 Tellurite resistance protein TerB - - - 0.00000000000000000000000000000001141 136.0
HKD2_k127_2938556_3 - - - - 0.000000000000000000000006866 106.0
HKD2_k127_2947_0 PFAM Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1423.0
HKD2_k127_2947_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1269.0
HKD2_k127_2947_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 1.458e-246 772.0
HKD2_k127_2947_4 polysaccharide export K01991,K20988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 286.0
HKD2_k127_2947_5 Methyl-viologen-reducing hydrogenase, delta subunit K14127 - 1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000001393 170.0
HKD2_k127_2947_6 Methyl-viologen-reducing hydrogenase, delta subunit K14127 - 1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000002803 140.0
HKD2_k127_2947_7 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000000000006261 129.0
HKD2_k127_2947_8 FAD dependent oxidoreductase - - - 0.000000000000000000000001988 103.0
HKD2_k127_2947_9 domain, Protein - - - 0.000000002478 64.0
HKD2_k127_2951204_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 347.0
HKD2_k127_2951204_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 296.0
HKD2_k127_2951204_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298 - 1.10.3.10,1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000001236 246.0
HKD2_k127_2951204_3 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000001794 231.0
HKD2_k127_2951204_4 Transcriptional regulator, DeoR family K21601 - - 0.0000000000000004766 84.0
HKD2_k127_2951204_5 lipoprotein involved in nitrous oxide reduction K21601 - - 0.00000000000008783 79.0
HKD2_k127_301444_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007686 341.0
HKD2_k127_301444_1 Glycerol-3-phosphate dehydrogenase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 342.0
HKD2_k127_301444_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000001094 222.0
HKD2_k127_301444_3 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term - - - 0.00000000000000000000000000000000000000000000002138 181.0
HKD2_k127_301444_4 - - - - 0.00000000000000000000000000000000000000000000005413 188.0
HKD2_k127_301444_5 O-acyltransferase activity K00661 - 2.3.1.79 0.0000000000000000000000000000000000000005736 158.0
HKD2_k127_3021172_0 - - - - 0.0 1477.0
HKD2_k127_3021172_1 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005236 264.0
HKD2_k127_3021172_2 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000008964 227.0
HKD2_k127_3021172_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000001341 229.0
HKD2_k127_3021172_4 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000001612 216.0
HKD2_k127_3032888_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1268.0
HKD2_k127_3032888_1 TIGRFAM arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 4.957e-254 794.0
HKD2_k127_3032888_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003808 283.0
HKD2_k127_3032888_3 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.00000000000000000000000000000000000000000000000000000000000007189 216.0
HKD2_k127_3032888_4 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.000000000000000000000000000000000000000000000000000000000002837 213.0
HKD2_k127_3054102_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 592.0
HKD2_k127_3054102_1 PFAM Binding-protein-dependent transport system inner membrane component K13895 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 546.0
HKD2_k127_3054102_2 PFAM Binding-protein-dependent transport system inner membrane component K13894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 538.0
HKD2_k127_3054102_3 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 397.0
HKD2_k127_3054102_4 Gtr1/RagA G protein conserved region K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 366.0
HKD2_k127_3054102_5 - K08086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005367 327.0
HKD2_k127_3054102_6 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000006639 253.0
HKD2_k127_3054102_7 Roadblock/LC7 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002613 244.0
HKD2_k127_3054102_8 Type II secretory pathway component ExeA K12283 - - 0.0000000000000000000000000000000000000000000000000000001051 213.0
HKD2_k127_3054102_9 - - - - 0.0000000000000000000000000000000004173 141.0
HKD2_k127_3055839_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.222e-246 770.0
HKD2_k127_3055839_1 Cytochrome c K08738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 335.0
HKD2_k127_3055839_2 NADH ubiquinone oxidoreductase 20 kDa subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000004213 224.0
HKD2_k127_3055839_3 PFAM Cytochrome c, class I - - - 0.0000000000000000000000000000000000000000002273 165.0
HKD2_k127_3055839_4 electron transfer activity K05337 - - 0.00000000000004175 73.0
HKD2_k127_3062098_0 Alpha amylase, C-terminal all-beta domain K00700 - 2.4.1.18 0.0 1035.0
HKD2_k127_3062098_1 PFAM ribonuclease II K01147,K12573 - 3.1.13.1 2.126e-224 714.0
HKD2_k127_3062098_10 Protein of unknown function (DUF445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 379.0
HKD2_k127_3062098_11 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 321.0
HKD2_k127_3062098_12 PFAM Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 287.0
HKD2_k127_3062098_13 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004101 279.0
HKD2_k127_3062098_14 PFAM ABC transporter K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006323 279.0
HKD2_k127_3062098_15 PFAM peptidase K21471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001713 262.0
HKD2_k127_3062098_16 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000002165 242.0
HKD2_k127_3062098_17 protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000000000007588 157.0
HKD2_k127_3062098_19 nuclear chromosome segregation - - - 0.0004492 51.0
HKD2_k127_3062098_2 Na H antiporter - - - 1.099e-200 634.0
HKD2_k127_3062098_3 Iron-containing alcohol dehydrogenase K00001,K08325 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008837 523.0
HKD2_k127_3062098_4 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 482.0
HKD2_k127_3062098_5 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 475.0
HKD2_k127_3062098_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 430.0
HKD2_k127_3062098_7 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000629 395.0
HKD2_k127_3062098_8 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 377.0
HKD2_k127_3062098_9 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 368.0
HKD2_k127_3072299_0 PFAM peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 565.0
HKD2_k127_3072299_1 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - - - 0.00000006157 55.0
HKD2_k127_3072299_2 - - - - 0.00001094 49.0
HKD2_k127_3079277_0 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 345.0
HKD2_k127_3079277_1 ABC-type transport system involved in lipoprotein release permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 331.0
HKD2_k127_3079277_2 Outer membrane lipoprotein-sorting protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005023 278.0
HKD2_k127_3090295_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 4.717e-285 897.0
HKD2_k127_3090295_1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530,K04764 - - 0.00000000000000000000000000000000000000001194 155.0
HKD2_k127_3090295_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000002787 134.0
HKD2_k127_3090295_3 PFAM regulatory protein, MerR - - - 0.00000000000000000000000000003457 121.0
HKD2_k127_3115832_0 class II (D K and N) K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 334.0
HKD2_k127_3115832_1 Belongs to the TtcA family K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001643 267.0
HKD2_k127_3115832_2 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003871 261.0
HKD2_k127_3115832_3 PFAM Imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000004214 165.0
HKD2_k127_3115832_4 - - - - 0.00000000000000000000000000005348 124.0
HKD2_k127_3143765_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1176.0
HKD2_k127_3143765_1 PFAM aminotransferase class I and II K11358 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 575.0
HKD2_k127_3143765_10 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000004165 109.0
HKD2_k127_3143765_11 PFAM peptidase domain protein - - - 0.0000000006813 70.0
HKD2_k127_3143765_12 amine dehydrogenase activity K01179,K01406,K07004 - 3.2.1.4,3.4.24.40 0.00000002097 66.0
HKD2_k127_3143765_13 pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0001823 50.0
HKD2_k127_3143765_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 450.0
HKD2_k127_3143765_3 Tellurite resistance protein TerB K05801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 409.0
HKD2_k127_3143765_4 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 334.0
HKD2_k127_3143765_5 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006725 318.0
HKD2_k127_3143765_6 - - - - 0.00000000000000000000000000000000000000000002743 174.0
HKD2_k127_3143765_7 regulator of chromosome condensation, RCC1 - - - 0.000000000000000000000000000000000000000008716 178.0
HKD2_k127_3143765_8 Curli production assembly/transport component CsgG - - - 0.000000000000000000000000000007086 134.0
HKD2_k127_3143765_9 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000128 134.0
HKD2_k127_3154432_0 serine-type endopeptidase activity K01312,K14647 GO:0005575,GO:0005576 3.4.21.4 1.03e-209 689.0
HKD2_k127_3154432_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 458.0
HKD2_k127_3170625_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 320.0
HKD2_k127_3170625_1 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009545 302.0
HKD2_k127_3170625_2 PFAM cytoplasmic chaperone TorD family protein - - - 0.000000000000000000000000000000000000193 151.0
HKD2_k127_3177876_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1086.0
HKD2_k127_3198738_0 response regulator K07715 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 519.0
HKD2_k127_3198738_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 437.0
HKD2_k127_3198738_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 404.0
HKD2_k127_3198738_3 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009732 292.0
HKD2_k127_3198738_4 Uncharacterised ACR, YagE family COG1723 - - - 0.00000000000000000000000000000000000000000000000000002693 198.0
HKD2_k127_3198738_5 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000002082 170.0
HKD2_k127_3206009_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 521.0
HKD2_k127_3206009_1 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000001824 145.0
HKD2_k127_3206009_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000004534 117.0
HKD2_k127_3206009_3 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00002072 49.0
HKD2_k127_3226555_0 AcrB/AcrD/AcrF family K03296,K18138 - - 0.0 1629.0
HKD2_k127_3226555_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation - - - 6.404e-269 844.0
HKD2_k127_3226555_10 MgtC family K07507 GO:0008150,GO:0009405,GO:0044419,GO:0051704 - 0.0000000000000000000000000000000000000000362 160.0
HKD2_k127_3226555_11 Uncharacterized ACR, COG1993 K06199,K09137 - - 0.00000000000000000000000000000000000001438 153.0
HKD2_k127_3226555_13 Copper binding periplasmic protein CusF - - - 0.00000000000000000000001372 104.0
HKD2_k127_3226555_14 - - - - 0.00000000000000000004066 94.0
HKD2_k127_3226555_15 Protein involved in outer membrane biogenesis - - - 0.0000000000000000009414 90.0
HKD2_k127_3226555_16 PIN domain - - - 0.00000000006788 66.0
HKD2_k127_3226555_2 HlyD family secretion protein K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 435.0
HKD2_k127_3226555_3 NADPH quinone reductase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 334.0
HKD2_k127_3226555_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001089 282.0
HKD2_k127_3226555_5 TIGRFAM histidinol phosphate phosphatase HisJ family K04486 - 3.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000001965 262.0
HKD2_k127_3226555_6 O-methyltransferase K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000001144 206.0
HKD2_k127_3226555_7 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000005774 199.0
HKD2_k127_3226555_8 Small Multidrug Resistance protein K11741 - - 0.00000000000000000000000000000000000000000000004284 171.0
HKD2_k127_3226555_9 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000000000000000000000008231 173.0
HKD2_k127_3257759_0 8-amino-7-oxononanoate synthase activity K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 400.0
HKD2_k127_3257759_1 NmrA-like family K00091 - 1.1.1.219 0.0000000000000004673 89.0
HKD2_k127_3257759_2 SNARE associated Golgi protein - - - 0.000000000000007626 78.0
HKD2_k127_3273902_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 7.165e-302 932.0
HKD2_k127_3273902_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.289e-212 666.0
HKD2_k127_3273902_10 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000003091 227.0
HKD2_k127_3273902_11 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000002382 214.0
HKD2_k127_3273902_12 PFAM conserved K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000007716 181.0
HKD2_k127_3273902_13 SMART Tetratricopeptide - - - 0.000000000000000000000000000000000000000000009548 169.0
HKD2_k127_3273902_14 addiction module antidote protein - - - 0.0000000000000000000000000000000000001229 143.0
HKD2_k127_3273902_15 PFAM Rieske 2Fe-2S K02636 - 1.10.9.1 0.00000000000000000000000000000000001357 142.0
HKD2_k127_3273902_16 Yqey-like protein K09117 - - 0.00000000000000000000000000000000007635 139.0
HKD2_k127_3273902_17 BrnA antitoxin of type II toxin-antitoxin system K03179 - 2.5.1.39 0.000000000000000000000678 98.0
HKD2_k127_3273902_19 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000000005432 64.0
HKD2_k127_3273902_2 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 522.0
HKD2_k127_3273902_3 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005847 393.0
HKD2_k127_3273902_4 Protein of unknown function (DUF1009) K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 391.0
HKD2_k127_3273902_5 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 379.0
HKD2_k127_3273902_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 342.0
HKD2_k127_3273902_7 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008109 341.0
HKD2_k127_3273902_8 TIGRFAM acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000006807 263.0
HKD2_k127_3273902_9 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000007417 271.0
HKD2_k127_3285161_0 pyruvate phosphate dikinase K01007 - 2.7.9.2 1.872e-285 902.0
HKD2_k127_3285161_1 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 600.0
HKD2_k127_3285161_2 PFAM ATP-binding region ATPase domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 389.0
HKD2_k127_3285161_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001443 243.0
HKD2_k127_3285161_4 phosphorelay signal transduction system - - - 0.000000000000000000000000000003059 123.0
HKD2_k127_3285161_5 Domain of unknown function (DUF1992) - - - 0.000000000000000000000000006982 112.0
HKD2_k127_3304729_0 Associated with various cellular activities K04748 - - 0.0 1079.0
HKD2_k127_3304729_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 8.096e-311 957.0
HKD2_k127_3304729_10 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000005468 269.0
HKD2_k127_3304729_11 Protein of unknown function DUF47 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003575 263.0
HKD2_k127_3304729_12 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001117 264.0
HKD2_k127_3304729_13 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002048 255.0
HKD2_k127_3304729_14 Domain of unknown function (DUF4149) - - - 0.00000000000000000000000000000000000000000000000000000000004155 213.0
HKD2_k127_3304729_15 TIGRFAM transcriptional regulator, Rrf2 family - - - 0.000000000000000000000000000000000000000000000000000000000175 207.0
HKD2_k127_3304729_16 Putative molybdenum carrier - - - 0.000000000000000000000000000000000000000000000000001108 195.0
HKD2_k127_3304729_17 lyase activity - - - 0.000000000000000000000000000000000000000000000000006361 202.0
HKD2_k127_3304729_18 - - - - 0.000000000000000000000000000000000000000000000001905 175.0
HKD2_k127_3304729_19 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000007324 158.0
HKD2_k127_3304729_2 PFAM cytochrome bd ubiquinol oxidase subunit I K00425 - 1.10.3.14 1.608e-233 731.0
HKD2_k127_3304729_21 PFAM nucleic acid binding, OB-fold, tRNA K01174 - 3.1.31.1 0.000000000000000000000001464 111.0
HKD2_k127_3304729_22 Domain of unknown function (DUF4492) - - - 0.00000000000000000002298 94.0
HKD2_k127_3304729_3 Cytochrome d ubiquinol oxidase, subunit II K00426 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000598 538.0
HKD2_k127_3304729_4 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 522.0
HKD2_k127_3304729_5 TIGRFAM branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 492.0
HKD2_k127_3304729_6 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009229 406.0
HKD2_k127_3304729_7 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 390.0
HKD2_k127_3304729_8 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005528 331.0
HKD2_k127_3304729_9 SMART Metal-dependent phosphohydrolase, HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 331.0
HKD2_k127_3321906_0 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001356 280.0
HKD2_k127_3321906_1 PFAM Glycosyl transferase family 2 K12992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001242 275.0
HKD2_k127_3321906_2 PFAM Glycosyl transferase family 2 K07011 - - 0.00000525 50.0
HKD2_k127_3340403_0 ATP-dependent helicase HrpB K03579 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 544.0
HKD2_k127_3340403_1 - - - - 0.00000000000000000000000000000000000000000000000000000000003059 211.0
HKD2_k127_3340403_2 - - - - 0.00000000000005972 77.0
HKD2_k127_3352545_0 Heavy metal transport detoxification protein K17686 - 3.6.3.54 3.743e-222 709.0
HKD2_k127_3379511_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 621.0
HKD2_k127_3379511_1 Papain family cysteine protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000444 506.0
HKD2_k127_3379511_2 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002401 270.0
HKD2_k127_3379511_3 Desulfoferrodoxin K05919 - 1.15.1.2 0.00000000000000000000000000000000000000001105 156.0
HKD2_k127_3379511_4 PFAM nuclease (SNase domain protein) - - - 0.000000000000000000000000000005871 126.0
HKD2_k127_3379511_5 PFAM Nitroreductase - - - 0.00000000009996 62.0
HKD2_k127_3443995_0 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 511.0
HKD2_k127_3443995_1 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.0000000000009464 71.0
HKD2_k127_3451709_0 PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 379.0
HKD2_k127_34894_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 462.0
HKD2_k127_34894_1 Bacterial transcriptional repressor C-terminal K16137 - - 0.00000000000000000000000000000000000000000606 162.0
HKD2_k127_3498277_0 Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 586.0
HKD2_k127_3498277_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.0000000000000000000000000000002497 131.0
HKD2_k127_35593_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 427.0
HKD2_k127_35593_1 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 406.0
HKD2_k127_35593_2 Putative ATP-binding cassette K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 358.0
HKD2_k127_35593_3 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 337.0
HKD2_k127_3568920_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 384.0
HKD2_k127_3568920_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 374.0
HKD2_k127_3568920_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 353.0
HKD2_k127_3568920_3 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 296.0
HKD2_k127_3568920_4 PFAM ABC transporter related K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000001781 276.0
HKD2_k127_3568920_5 Catalyzes the insertion of Co(2 ) into sirohydrochlorin K02190 GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0016829,GO:0016852,GO:0020037,GO:0022607,GO:0042597,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050897,GO:0051259,GO:0051262,GO:0051266,GO:0065003,GO:0071840,GO:0097159,GO:1901363 4.99.1.3 0.0000000000000000000000000000000000000000000000000000000006184 216.0
HKD2_k127_3568920_6 Outer membrane protein beta-barrel family K02014 - - 0.000000000000000000000000000000000000000000002067 171.0
HKD2_k127_3568920_7 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000002228 98.0
HKD2_k127_3599454_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 331.0
HKD2_k127_3599454_1 YbbR-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001884 257.0
HKD2_k127_3599454_2 Domain of Unknown Function (DUF748) - - - 0.000000006133 69.0
HKD2_k127_3599454_3 Protein of unknown function - - - 0.0006847 53.0
HKD2_k127_3623967_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 3.077e-233 728.0
HKD2_k127_3623967_1 type IV pilus assembly PilZ - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 537.0
HKD2_k127_3623967_2 PFAM Outer membrane protein transport protein (OMPP1 FadL TodX) K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 407.0
HKD2_k127_3623967_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006551 392.0
HKD2_k127_3623967_4 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009339 359.0
HKD2_k127_3623967_5 PFAM Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006808 243.0
HKD2_k127_3623967_6 molybdopterin-guanine dinucleotide biosynthesis protein K03753,K13818 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.7.7.77 0.000000000000000000000000000000000000000000000000000006113 202.0
HKD2_k127_3623967_7 PFAM Methyltransferase type 11 - - - 0.000000000005709 66.0
HKD2_k127_3663947_0 PFAM ferredoxin - - - 2.342e-268 841.0
HKD2_k127_3663947_1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.000000000000000000000000000000000000000000000000000000000111 208.0
HKD2_k127_3677139_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 501.0
HKD2_k127_3677139_1 SEC-C motif K07039 - - 0.000000000000000000000000000000001227 139.0
HKD2_k127_3684548_0 Polysaccharide biosynthesis protein K15912 - 4.2.1.135 3.856e-218 694.0
HKD2_k127_3684548_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 505.0
HKD2_k127_3684548_10 PFAM Glycosyl transferases group 1 K16703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 326.0
HKD2_k127_3684548_11 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000000000007252 210.0
HKD2_k127_3684548_12 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000002365 192.0
HKD2_k127_3684548_13 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000003652 173.0
HKD2_k127_3684548_14 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000000002655 177.0
HKD2_k127_3684548_15 acetyltransferase - - - 0.00000000000000000000000000000000000000003019 162.0
HKD2_k127_3684548_16 G-rich domain on putative tyrosine kinase - - - 0.0000000000000000000000000004022 128.0
HKD2_k127_3684548_17 PFAM transferase hexapeptide repeat containing protein K00661 - 2.3.1.79 0.00000000000000006628 90.0
HKD2_k127_3684548_18 - - - - 0.000000000005198 79.0
HKD2_k127_3684548_19 transferase activity, transferring glycosyl groups - - - 0.00000000003984 75.0
HKD2_k127_3684548_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 493.0
HKD2_k127_3684548_20 Proprotein convertase P-domain - - - 0.00000005365 56.0
HKD2_k127_3684548_21 Protein conserved in bacteria K20444 - - 0.000002408 53.0
HKD2_k127_3684548_22 CarboxypepD_reg-like domain - - - 0.00006736 54.0
HKD2_k127_3684548_23 transposition - - - 0.0005702 51.0
HKD2_k127_3684548_3 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 452.0
HKD2_k127_3684548_4 Wzt C-terminal domain K01990,K09691,K09693 - 3.6.3.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 387.0
HKD2_k127_3684548_5 PFAM Glycosyl transferase family 2 K10012 - 2.4.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 369.0
HKD2_k127_3684548_6 ABC-2 type transporter K09690,K09692 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 344.0
HKD2_k127_3684548_7 Nodulation protein S (NodS) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 335.0
HKD2_k127_3684548_8 methyltransferase activity K00563,K02169 - 2.1.1.187,2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 324.0
HKD2_k127_3684548_9 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid K03328,K16694,K16695 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 331.0
HKD2_k127_3700774_0 PFAM peptidase K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 536.0
HKD2_k127_3700774_1 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 421.0
HKD2_k127_3700774_10 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.00000004278 58.0
HKD2_k127_3700774_2 cytochrome complex assembly - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 408.0
HKD2_k127_3700774_3 AAA domain K03546 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 283.0
HKD2_k127_3700774_4 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003049 279.0
HKD2_k127_3700774_5 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000002865 271.0
HKD2_k127_3700774_6 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002486 263.0
HKD2_k127_3700774_7 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000000000000000000008025 239.0
HKD2_k127_3700774_8 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000004391 186.0
HKD2_k127_3730450_0 Belongs to the ompA family K03286 - - 0.0000000000000000000000000000000000000000000000000000001532 208.0
HKD2_k127_3730450_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000003224 150.0
HKD2_k127_3734503_0 cell adhesion involved in biofilm formation K12287 - - 5.063e-308 972.0
HKD2_k127_3734503_1 PFAM sigma-54 factor interaction domain-containing protein K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006955 498.0
HKD2_k127_3734503_2 SMART ATP-binding region ATPase domain protein K07710 - 2.7.13.3 0.00000000000000000000000000000000000000001092 174.0
HKD2_k127_3735453_0 CBS domain K00974 - 2.7.7.72 0.0 1233.0
HKD2_k127_3735453_1 Protein of unknown function (DUF3047) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007611 255.0
HKD2_k127_3735453_2 auxin-activated signaling pathway K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000123 250.0
HKD2_k127_3735453_3 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000002284 205.0
HKD2_k127_3741551_0 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 485.0
HKD2_k127_3741551_1 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008179 327.0
HKD2_k127_3789151_0 Response regulator receiver K03415 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 459.0
HKD2_k127_3789151_1 Response regulator receiver K03415 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 448.0
HKD2_k127_3789151_2 Response regulator receiver K03413 - - 0.000003188 52.0
HKD2_k127_378934_0 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000003583 236.0
HKD2_k127_378934_1 Methyltransferase, chemotaxis proteins K00575,K03411,K03412 - 2.1.1.80,3.1.1.61,3.5.1.44 0.00000000000000000000000000002562 124.0
HKD2_k127_378934_2 - - - - 0.0005125 48.0
HKD2_k127_3804232_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 501.0
HKD2_k127_3804232_1 - K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 403.0
HKD2_k127_3804232_2 sulfur carrier activity K07112 GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - 0.000000000000000008983 88.0
HKD2_k127_3804232_3 Histidine kinase - - - 0.00000000000000001316 98.0
HKD2_k127_3817864_0 PFAM Radical SAM - - - 4.339e-217 688.0
HKD2_k127_3817864_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 6.054e-209 655.0
HKD2_k127_3817864_10 Essential cell division protein K03589 - - 0.0000000000000000000000000000000000000000000000001372 189.0
HKD2_k127_3817864_2 Belongs to the MurCDEF family K01924 - 6.3.2.8 1.118e-205 649.0
HKD2_k127_3817864_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006165 576.0
HKD2_k127_3817864_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007293 541.0
HKD2_k127_3817864_5 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 426.0
HKD2_k127_3817864_6 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 366.0
HKD2_k127_3817864_7 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 352.0
HKD2_k127_3817864_8 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000004134 274.0
HKD2_k127_3817864_9 Protein involved in outer membrane biogenesis - - - 0.000000000000000000000000000000000000000000000000000000000008563 236.0
HKD2_k127_3841165_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 602.0
HKD2_k127_3841165_1 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily K01002 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006490,GO:0006629,GO:0008150,GO:0008152,GO:0008960,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0042597,GO:0044237,GO:0044238,GO:0044255,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576 2.7.8.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 541.0
HKD2_k127_3841165_10 high-affinity sulfate:proton symporter activity K06203 GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000933 258.0
HKD2_k127_3841165_11 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000005637 235.0
HKD2_k127_3841165_12 ribosomal large subunit export from nucleus - - - 0.0000000000000000000000000000000000000000000000000000000000001233 216.0
HKD2_k127_3841165_13 Putative nucleotidyltransferase substrate binding domain K07182 - - 0.0000000000000000000000000000000000000000000000000000005866 204.0
HKD2_k127_3841165_14 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000001571 194.0
HKD2_k127_3841165_15 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.000000000000000000000000000000000004855 141.0
HKD2_k127_3841165_16 - - - - 0.0000000000000000000000000000000003107 136.0
HKD2_k127_3841165_17 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000002103 114.0
HKD2_k127_3841165_2 PFAM Cys Met metabolism K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 440.0
HKD2_k127_3841165_21 to Saccharomyces cerevisiae MET17 (YLR303W) K17069 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 0.0002392 48.0
HKD2_k127_3841165_3 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006181 428.0
HKD2_k127_3841165_4 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 424.0
HKD2_k127_3841165_5 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005611 421.0
HKD2_k127_3841165_6 cysteine synthase K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004044 396.0
HKD2_k127_3841165_7 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 337.0
HKD2_k127_3841165_8 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 306.0
HKD2_k127_3841165_9 TIGRFAM methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000276 288.0
HKD2_k127_3868416_0 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 310.0
HKD2_k127_3868416_1 Type II secretory pathway component ExeA K12283 - - 0.0000000000000000000000003231 113.0
HKD2_k127_3886418_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 454.0
HKD2_k127_3886418_1 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 309.0
HKD2_k127_3886418_2 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000001916 268.0
HKD2_k127_3886418_3 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000434 224.0
HKD2_k127_3886418_4 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000003837 174.0
HKD2_k127_3886418_5 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000002549 113.0
HKD2_k127_3886418_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000515 82.0
HKD2_k127_3886418_7 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 0.000000002863 58.0
HKD2_k127_3891705_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02621 - - 9.336e-279 868.0
HKD2_k127_3891705_1 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 308.0
HKD2_k127_3891705_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000008097 208.0
HKD2_k127_3902745_0 TIGRFAM sulfite reductase, dissimilatory-type alpha subunit K11180 - 1.8.99.5 4.972e-260 803.0
HKD2_k127_3902745_1 Belongs to the GPI family K01810 - 5.3.1.9 1.254e-225 709.0
HKD2_k127_3902745_10 - - - - 0.0000003597 53.0
HKD2_k127_3902745_2 TIGRFAM sulfite reductase, dissimilatory-type beta subunit K11181 - 1.8.99.5 1.685e-218 681.0
HKD2_k127_3902745_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 600.0
HKD2_k127_3902745_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 516.0
HKD2_k127_3902745_5 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 324.0
HKD2_k127_3902745_6 TIGRFAM DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 319.0
HKD2_k127_3902745_7 Alcohol dehydrogenase GroES-like domain K00001,K19745 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001818 263.0
HKD2_k127_3902745_8 biotin-[acetyl-CoA-carboxylase] ligase activity K03524 - 6.3.4.15 0.0000000000000000000000000000000000000004339 159.0
HKD2_k127_3902745_9 Dissimilatory sulfite reductase D (DsrD) - - - 0.000000000000000000000000000006072 121.0
HKD2_k127_3904661_0 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 421.0
HKD2_k127_3904661_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000002427 140.0
HKD2_k127_3944444_0 Signal transducing histidine kinase, homodimeric K02487,K06596 - - 3.54e-207 674.0
HKD2_k127_3944444_1 phosphate ion binding K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001073 265.0
HKD2_k127_3944444_2 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000000000000001921 187.0
HKD2_k127_3944444_3 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000000000000000000000000000000001344 186.0
HKD2_k127_3944444_4 phosphorelay signal transduction system K13599 - - 0.000000000000000000000000000000000000000006931 162.0
HKD2_k127_3944444_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000002319 149.0
HKD2_k127_3944444_6 Two component signalling adaptor domain - - - 0.000000000000000000000000000001245 127.0
HKD2_k127_3944444_7 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000001875 118.0
HKD2_k127_3944444_8 chemotaxis protein K03407 - 2.7.13.3 0.0000000000000000002006 103.0
HKD2_k127_3945087_0 SMART Elongator protein 3 MiaB NifB - - - 1.015e-308 967.0
HKD2_k127_3945087_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 1.511e-234 732.0
HKD2_k127_3945087_10 helix_turn_helix, mercury resistance K13640 - - 0.0000000000000000000000000000000000000000000000000000000006816 203.0
HKD2_k127_3945087_11 helix_turn_helix, mercury resistance K13640 - - 0.000000000000000000000000000000000000000000000000000001308 197.0
HKD2_k127_3945087_12 translation initiation factor activity K02237,K03497,K12065 - - 0.0000000000000000000000000000000000000000000000009069 189.0
HKD2_k127_3945087_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 4.004e-229 728.0
HKD2_k127_3945087_3 PFAM Polysulphide reductase, NrfD K00185 - - 7.777e-212 663.0
HKD2_k127_3945087_4 Bacterial regulatory protein, Fis family - - - 7.512e-195 623.0
HKD2_k127_3945087_5 PFAM Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 506.0
HKD2_k127_3945087_6 PFAM 4Fe-4S dicluster domain K04014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007577 422.0
HKD2_k127_3945087_7 PFAM Cytochrome c, bacterial - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 392.0
HKD2_k127_3945087_8 PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 297.0
HKD2_k127_3945087_9 denitrification pathway - - - 0.0000000000000000000000000000000000000000000000000000000000000004379 227.0
HKD2_k127_3952699_0 thiamine pyrophosphate protein TPP binding domain protein K00156,K01652 - 1.2.5.1,2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 529.0
HKD2_k127_3952699_1 TonB-dependent Receptor Plug Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 460.0
HKD2_k127_3952699_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000001431 127.0
HKD2_k127_3952699_3 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000001818 120.0
HKD2_k127_3952699_4 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000002885 119.0
HKD2_k127_3952699_5 - - - - 0.0000000000000000000003899 110.0
HKD2_k127_3952699_6 organic phosphonate transport K02044 - - 0.00000000000003137 83.0
HKD2_k127_3977392_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 2.963e-218 707.0
HKD2_k127_3977392_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 - 3.1.11.2,4.2.99.18 5.805e-204 646.0
HKD2_k127_3977392_2 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 379.0
HKD2_k127_3977392_3 class II (D K and N) K04568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 346.0
HKD2_k127_3977392_4 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 332.0
HKD2_k127_3977392_5 Belongs to the small heat shock protein (HSP20) family - - - 0.00000000000000000000000000000000000000000000002189 174.0
HKD2_k127_3977392_6 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000000000000000000000000002513 171.0
HKD2_k127_3977392_7 - - - - 0.000000000000000000000000000000000000000000007257 170.0
HKD2_k127_3977392_8 Phosphoesterase K07095 - - 0.0000000000000000000000000000000000000001574 156.0
HKD2_k127_3977392_9 Diguanylate cyclase - - - 0.000000000000000000000000001196 131.0
HKD2_k127_3981205_0 epimerase dehydratase K19997 - 5.1.3.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007396 570.0
HKD2_k127_3981205_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 421.0
HKD2_k127_3981205_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 366.0
HKD2_k127_3981205_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 295.0
HKD2_k127_3981205_4 Probably functions as a manganese efflux pump - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001722 251.0
HKD2_k127_3981205_5 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000007033 235.0
HKD2_k127_3981205_6 Thioredoxin-like - - - 0.00000000000000000000000000000000000000111 156.0
HKD2_k127_3981205_7 Response regulator receiver - - - 0.0000000000000000000000000000007671 126.0
HKD2_k127_3987609_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 597.0
HKD2_k127_3987609_1 PFAM Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 505.0
HKD2_k127_3987609_2 IS30 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 332.0
HKD2_k127_3987609_3 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000002823 254.0
HKD2_k127_3987609_4 COG3210 Large exoproteins involved in heme utilization or adhesion - - - 0.000000000000000000000000000000000000000000000000000000002982 203.0
HKD2_k127_3987609_5 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000000000000000001316 191.0
HKD2_k127_3987609_6 - - - - 0.000000000000000000000000000000000000000000000001479 185.0
HKD2_k127_3987609_7 - - - - 0.000000000000000000000000000003637 123.0
HKD2_k127_4005883_0 PFAM Acyl-CoA dehydrogenase K00248 - 1.3.8.1 5.273e-210 656.0
HKD2_k127_4005883_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 7.618e-206 648.0
HKD2_k127_4005883_10 heat shock protein DnaJ domain protein K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 416.0
HKD2_k127_4005883_11 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 402.0
HKD2_k127_4005883_12 PFAM Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 393.0
HKD2_k127_4005883_13 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 376.0
HKD2_k127_4005883_14 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 368.0
HKD2_k127_4005883_15 PFAM ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 337.0
HKD2_k127_4005883_16 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 315.0
HKD2_k127_4005883_17 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004549 286.0
HKD2_k127_4005883_18 PFAM VacJ family lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004798 263.0
HKD2_k127_4005883_19 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002155 256.0
HKD2_k127_4005883_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 8.403e-206 656.0
HKD2_k127_4005883_20 Single-stranded DNA-binding protein K03111 - - 0.00000000000000000000000000000000000000000000000000000000003597 214.0
HKD2_k127_4005883_21 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000002268 202.0
HKD2_k127_4005883_22 PFAM Mammalian cell entry related domain protein K02067 - - 0.00000000000000000000000000000000000000000000000000000001585 200.0
HKD2_k127_4005883_23 ribose 5-phosphate isomerase B K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000003863 190.0
HKD2_k127_4005883_24 PFAM toluene tolerance family protein K07323 - - 0.00000000000000000000000000000000000000000000000001233 189.0
HKD2_k127_4005883_25 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000009691 130.0
HKD2_k127_4005883_26 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000000000002124 136.0
HKD2_k127_4005883_27 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000009333 132.0
HKD2_k127_4005883_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 3.4e-205 644.0
HKD2_k127_4005883_30 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000001926 100.0
HKD2_k127_4005883_31 Phosphocarrier protein HPr K08485,K11189 - - 0.0000002485 59.0
HKD2_k127_4005883_4 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 617.0
HKD2_k127_4005883_5 Electron transfer flavoprotein, alpha subunit K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 544.0
HKD2_k127_4005883_6 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 537.0
HKD2_k127_4005883_7 radical SAM domain protein K03716 - 4.1.99.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 519.0
HKD2_k127_4005883_8 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 438.0
HKD2_k127_4005883_9 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 436.0
HKD2_k127_4053004_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 1.497e-221 696.0
HKD2_k127_4053004_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00125 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 334.0
HKD2_k127_4053004_2 Methyl-viologen-reducing hydrogenase, delta subunit K14127 - 1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000001807 197.0
HKD2_k127_4078108_0 PFAM ferredoxin - - - 2.5e-323 1004.0
HKD2_k127_4078108_1 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 8.05e-322 1001.0
HKD2_k127_4078108_10 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 377.0
HKD2_k127_4078108_11 phosphorelay sensor kinase activity K02668,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 376.0
HKD2_k127_4078108_12 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 370.0
HKD2_k127_4078108_13 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 329.0
HKD2_k127_4078108_14 Methylates ribosomal protein L11 K02687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001012 266.0
HKD2_k127_4078108_15 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009381 250.0
HKD2_k127_4078108_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000156 236.0
HKD2_k127_4078108_17 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000003357 211.0
HKD2_k127_4078108_18 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000002704 196.0
HKD2_k127_4078108_19 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000001949 197.0
HKD2_k127_4078108_2 ABC transporter K06020 - 3.6.3.25 1.42e-311 961.0
HKD2_k127_4078108_20 Protein of unknown function (DUF3302) - - - 0.00000000000000000000000000000000000000000000000002673 187.0
HKD2_k127_4078108_21 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000001036 161.0
HKD2_k127_4078108_23 23S rRNA-intervening sequence protein - - - 0.000000000000000000000000000000000003207 141.0
HKD2_k127_4078108_24 IMP dehydrogenase activity - - - 0.00000000000000000000000000000003354 131.0
HKD2_k127_4078108_25 Protein of unknown function (DUF504) - - - 0.0000000000000000000000000008274 114.0
HKD2_k127_4078108_26 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000001444 101.0
HKD2_k127_4078108_27 - - - - 0.00000000000003289 79.0
HKD2_k127_4078108_28 Cytochrome c bacterial - - - 0.0000000075 64.0
HKD2_k127_4078108_3 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 2.141e-280 870.0
HKD2_k127_4078108_4 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 1.187e-274 859.0
HKD2_k127_4078108_5 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 2.847e-250 783.0
HKD2_k127_4078108_6 arsenite transmembrane transporter activity - - - 7.878e-194 614.0
HKD2_k127_4078108_7 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 455.0
HKD2_k127_4078108_8 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 430.0
HKD2_k127_4078108_9 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000728 413.0
HKD2_k127_408859_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1114.0
HKD2_k127_408859_1 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 427.0
HKD2_k127_408859_2 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 306.0
HKD2_k127_408859_3 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004281 257.0
HKD2_k127_408859_4 Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily K00850 - 2.7.1.11 0.000000000000000000000000000000000000000000000002312 177.0
HKD2_k127_4097056_0 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006193 285.0
HKD2_k127_4097056_1 Putative exonuclease, RdgC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003736 263.0
HKD2_k127_4149107_0 Phage integrase, N-terminal SAM-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 548.0
HKD2_k127_4149107_1 HMGL-like K01666 - 4.1.3.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 426.0
HKD2_k127_4149107_2 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000001171 174.0
HKD2_k127_4149107_3 Aldolase K01625 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 4.1.2.14,4.1.3.42 0.00000000000000000000000000000000000000000006281 167.0
HKD2_k127_4149107_5 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000002296 118.0
HKD2_k127_415500_0 TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0 1142.0
HKD2_k127_415500_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 606.0
HKD2_k127_415500_2 PFAM Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 348.0
HKD2_k127_4156960_0 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 493.0
HKD2_k127_4156960_1 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 459.0
HKD2_k127_4156960_2 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000004014 156.0
HKD2_k127_4156960_3 Rhodanese-like domain - - - 0.000000000000000000000000001031 118.0
HKD2_k127_4168154_0 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 1.212e-258 808.0
HKD2_k127_4168154_1 Glycogen debranching enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 500.0
HKD2_k127_4168154_2 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005161 355.0
HKD2_k127_4168154_3 PFAM 4Fe-4S ferredoxin iron-sulfur binding - - - 0.00000000000000000000000001519 109.0
HKD2_k127_4168730_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1259.0
HKD2_k127_4168730_1 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 375.0
HKD2_k127_4169399_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1030.0
HKD2_k127_4169399_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01945 - 6.3.4.13 5.022e-270 842.0
HKD2_k127_4169399_10 PIN domain - - - 0.0000000000000000000000000000000000000000000000000000002232 196.0
HKD2_k127_4169399_11 PIN domain - - - 0.0000000000000000000000000000000000000000000000000000827 189.0
HKD2_k127_4169399_12 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000000000308 104.0
HKD2_k127_4169399_13 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000001538 89.0
HKD2_k127_4169399_14 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000000003111 64.0
HKD2_k127_4169399_15 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000001129 63.0
HKD2_k127_4169399_16 PA domain - - - 0.00001286 54.0
HKD2_k127_4169399_17 TIGRFAM addiction module toxin, RelE StbE family K06218 - - 0.0003497 47.0
HKD2_k127_4169399_2 serine-type endopeptidase activity K01312,K14647 GO:0005575,GO:0005576 3.4.21.4 6.204e-218 711.0
HKD2_k127_4169399_3 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 582.0
HKD2_k127_4169399_4 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 507.0
HKD2_k127_4169399_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003691 502.0
HKD2_k127_4169399_6 Tetracycline transcriptional regulator YsiA domain protein K13770 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 287.0
HKD2_k127_4169399_7 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000402 248.0
HKD2_k127_4169399_8 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000000000000000000000000000000001007 226.0
HKD2_k127_4169399_9 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000001175 201.0
HKD2_k127_4178340_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1136.0
HKD2_k127_4178340_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 8.494e-207 655.0
HKD2_k127_4178340_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 388.0
HKD2_k127_4178340_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 368.0
HKD2_k127_4178340_4 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 370.0
HKD2_k127_4178340_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 327.0
HKD2_k127_4178340_6 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K09765 - 1.17.99.6 0.00000000000000000000002922 100.0
HKD2_k127_4178340_7 Toxic component of a toxin-antitoxin (TA) module. An RNase K00640,K07062 - 2.3.1.30 0.00007105 46.0
HKD2_k127_4193035_0 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 435.0
HKD2_k127_4193035_1 PFAM Ubiquitin-conjugating - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 325.0
HKD2_k127_4193035_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000799 130.0
HKD2_k127_4193035_4 Predicted RNA-binding protein - - - 0.0000000000007203 71.0
HKD2_k127_4204574_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 - - 2.175e-263 819.0
HKD2_k127_4204574_1 NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 4.426e-199 631.0
HKD2_k127_4204574_2 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000004107 270.0
HKD2_k127_4204574_3 PhoQ Sensor - - - 0.00000000000000000000000000000000000002703 157.0
HKD2_k127_4204574_4 amino acid activation for nonribosomal peptide biosynthetic process K06045 - 4.2.1.129,5.4.99.17 0.00000000000001335 84.0
HKD2_k127_4209791_0 Elongation factor Tu domain 2 K02355 - - 0.0 1033.0
HKD2_k127_4209791_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 8.224e-215 679.0
HKD2_k127_4209791_2 PFAM type II secretion system protein E K02669 - - 2.346e-205 642.0
HKD2_k127_4209791_3 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009332 501.0
HKD2_k127_4209791_4 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 497.0
HKD2_k127_4209791_5 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 324.0
HKD2_k127_4209791_6 RNA methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004331 239.0
HKD2_k127_4209791_7 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000001131 220.0
HKD2_k127_4209791_8 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000003546 79.0
HKD2_k127_4210677_0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 328.0
HKD2_k127_4210677_1 GGDEF domain K21088 - 2.7.7.65 0.000000000000000000000000000000000001277 140.0
HKD2_k127_4210677_2 oligosaccharyl transferase activity - - - 0.00000000000000000000000002467 126.0
HKD2_k127_4215397_1 4Fe-4S ferredoxin iron-sulfur binding domain protein K05337 - - 0.00000000000000000000001056 102.0
HKD2_k127_4234536_0 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005295 291.0
HKD2_k127_4234536_1 FecR protein - - - 0.00000000000000000000000000000000000000000000000000000000003298 219.0
HKD2_k127_4234536_2 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00002136 52.0
HKD2_k127_4246914_0 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006409 352.0
HKD2_k127_4246914_1 PFAM Integrase catalytic - - - 0.0000000000000000000000000000000000000000000000000000000000000000004634 241.0
HKD2_k127_4246914_2 protocatechuate 3,4-dioxygenase activity K03381 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006725,GO:0008150,GO:0008152,GO:0008199,GO:0009056,GO:0009712,GO:0009987,GO:0016491,GO:0016701,GO:0016702,GO:0018576,GO:0018958,GO:0019114,GO:0019336,GO:0019439,GO:0019614,GO:0019615,GO:0042952,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 1.13.11.1 0.00000000000000000000000000000000000000000000000001068 182.0
HKD2_k127_4246914_4 Belongs to the peptidase S8 family - - - 0.000000000001677 77.0
HKD2_k127_4291176_0 phosphorelay sensor kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 410.0
HKD2_k127_4291176_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000009781 239.0
HKD2_k127_4291176_2 ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000001517 164.0
HKD2_k127_4291176_3 histidine kinase A domain protein - - - 0.000000000000000000000000000000001102 150.0
HKD2_k127_4291176_4 COG1226 Kef-type K transport systems - - - 0.00000000000000000000000000006284 122.0
HKD2_k127_4291176_5 Universal stress protein family - - - 0.00000000000000000000000001607 115.0
HKD2_k127_4291176_6 thiamine pyrophosphate protein TPP binding domain protein K00156,K01652 - 1.2.5.1,2.2.1.6 0.0001812 44.0
HKD2_k127_4339064_0 PFAM ABC transporter related - - - 3.897e-286 887.0
HKD2_k127_4339064_1 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 601.0
HKD2_k127_4339064_2 General secretory system II protein E domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 490.0
HKD2_k127_4339064_3 response to cobalt ion - - - 0.00000000000000000000000000000000000000000001445 167.0
HKD2_k127_434042_0 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 441.0
HKD2_k127_434042_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006126 278.0
HKD2_k127_4340780_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 554.0
HKD2_k127_4340780_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005878 540.0
HKD2_k127_4340780_10 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005505 270.0
HKD2_k127_4340780_11 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000002085 214.0
HKD2_k127_4340780_12 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000001806 198.0
HKD2_k127_4340780_13 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000002417 181.0
HKD2_k127_4340780_14 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000005675 187.0
HKD2_k127_4340780_15 PFAM peptidase M22 glycoprotease K01409,K14742 - 2.3.1.234 0.00000000000000000000000000000000000000000001099 171.0
HKD2_k127_4340780_16 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000000004392 92.0
HKD2_k127_4340780_17 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000002084 67.0
HKD2_k127_4340780_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 500.0
HKD2_k127_4340780_3 SMART PDZ DHR GLGF domain protein K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 463.0
HKD2_k127_4340780_4 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008969 391.0
HKD2_k127_4340780_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 333.0
HKD2_k127_4340780_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005215 331.0
HKD2_k127_4340780_7 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 334.0
HKD2_k127_4340780_8 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 314.0
HKD2_k127_4340780_9 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008633 280.0
HKD2_k127_4345574_0 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 4.413e-263 819.0
HKD2_k127_4345574_1 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 400.0
HKD2_k127_4345574_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K09765 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000002637 256.0
HKD2_k127_4345574_3 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000007682 199.0
HKD2_k127_4345574_4 SH3 domain - - - 0.000000000000000000000000000000000000000000000001281 178.0
HKD2_k127_4345574_5 TIGRFAM Protein of - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000005605 104.0
HKD2_k127_4382494_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 9.888e-243 760.0
HKD2_k127_4382494_1 class II (D K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007109 344.0
HKD2_k127_4382494_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 288.0
HKD2_k127_4382494_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006812 272.0
HKD2_k127_4382494_4 PilZ domain - - - 0.000000000000000000000000000000000005501 143.0
HKD2_k127_4383857_0 TIGRFAM ATP-dependent helicase HrpA K03578,K03579 - 3.6.4.13 0.0 1264.0
HKD2_k127_4383857_1 Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 464.0
HKD2_k127_4383857_2 TIGRFAM Pyridine nucleotide-disulfide oxidoreductase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 437.0
HKD2_k127_4383857_3 NAD dependent epimerase/dehydratase family K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 332.0
HKD2_k127_4383857_4 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 297.0
HKD2_k127_4383857_5 Dodecin K09165 - - 0.000000000000000000000003896 104.0
HKD2_k127_4383857_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000003696 91.0
HKD2_k127_4383857_7 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00006046 46.0
HKD2_k127_4389535_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 381.0
HKD2_k127_4389535_1 PFAM Response regulator receiver domain K02481,K07712,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 318.0
HKD2_k127_4389535_2 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000005996 240.0
HKD2_k127_4389535_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.000000000000000000000000000000000000000000000000000000000000213 213.0
HKD2_k127_4408203_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1137.0
HKD2_k127_4408203_1 PFAM Radical SAM domain protein K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 604.0
HKD2_k127_4408203_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 314.0
HKD2_k127_4408203_3 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 317.0
HKD2_k127_4408203_4 Universal stress protein family K06149 - - 0.00000000000000000000000000000000000000000000000000000000006745 209.0
HKD2_k127_4438204_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 4.333e-222 696.0
HKD2_k127_4438204_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 518.0
HKD2_k127_4438204_2 FAD binding domain K10960,K21401 - 1.3.1.111,1.3.1.83,1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005889 347.0
HKD2_k127_4438204_3 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 290.0
HKD2_k127_4438204_4 - - - - 0.00000000000000000000000000000000000000000002465 183.0
HKD2_k127_4438204_5 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000000001148 124.0
HKD2_k127_4474164_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 8.906e-268 840.0
HKD2_k127_4474164_1 Domain of unknown function DUF87 - - - 6.336e-241 770.0
HKD2_k127_4474164_2 DnaB-like helicase C terminal domain - - - 2.134e-220 699.0
HKD2_k127_4474164_3 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 380.0
HKD2_k127_4474164_4 cyclic nucleotide-binding K10914 - - 0.00000000000000000000000000000000000000000000000000000000000002674 222.0
HKD2_k127_4474164_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000000000153 100.0
HKD2_k127_4492516_0 PFAM Cytochrome c, class I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 576.0
HKD2_k127_4492516_1 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000098 283.0
HKD2_k127_4493571_0 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 338.0
HKD2_k127_4493571_1 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 327.0
HKD2_k127_4493571_2 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000003042 153.0
HKD2_k127_4493571_4 - - - - 0.00000000000000001573 90.0
HKD2_k127_4525966_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.67e-230 725.0
HKD2_k127_4525966_1 PFAM Metallo-beta-lactamase superfamily K22405 - 1.6.3.4 4.658e-215 672.0
HKD2_k127_4525966_10 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.000000000000000000000000000000000000000000001442 173.0
HKD2_k127_4525966_11 PFAM DsrE DsrF-like family - - - 0.0000000000000000000000000000000000000012 150.0
HKD2_k127_4525966_12 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000000000000000000000003148 147.0
HKD2_k127_4525966_13 peroxiredoxin activity - - - 0.00000000000000000000000000000000003801 139.0
HKD2_k127_4525966_14 - - - - 0.00000000000000000000000000000000003861 136.0
HKD2_k127_4525966_16 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000512 110.0
HKD2_k127_4525966_17 rubredoxin - - - 0.00000000000000000000009304 100.0
HKD2_k127_4525966_19 PFAM Rubrerythrin - - - 0.00000000001001 64.0
HKD2_k127_4525966_2 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 575.0
HKD2_k127_4525966_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 554.0
HKD2_k127_4525966_4 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 542.0
HKD2_k127_4525966_5 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 501.0
HKD2_k127_4525966_6 PFAM Histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006742 421.0
HKD2_k127_4525966_7 PFAM Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003677 272.0
HKD2_k127_4525966_8 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000006841 236.0
HKD2_k127_4525966_9 Desulfoferrodoxin ferrous iron-binding K05919 - 1.15.1.2 0.000000000000000000000000000000000000000000000000000000000000001746 220.0
HKD2_k127_4556107_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009209 514.0
HKD2_k127_4556107_1 Outer membrane protein beta-barrel family K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 513.0
HKD2_k127_4556107_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 417.0
HKD2_k127_4556107_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 334.0
HKD2_k127_4556107_4 TonB-dependent Receptor Plug K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 290.0
HKD2_k127_4556107_5 PFAM MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000001108 206.0
HKD2_k127_4556107_6 Domain of unknown function (DUF4154) - - - 0.00000000000000000006669 98.0
HKD2_k127_4556107_7 AsmA-like C-terminal region K07289 - - 0.000000784 53.0
HKD2_k127_4556107_8 Type II secretion system (T2SS), protein E, N-terminal domain K02652 - - 0.0003231 53.0
HKD2_k127_456010_0 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 1.215e-295 909.0
HKD2_k127_456010_1 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 461.0
HKD2_k127_456010_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001044 278.0
HKD2_k127_456010_3 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000003718 217.0
HKD2_k127_4597876_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 8.273e-295 909.0
HKD2_k127_4597876_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.274e-249 777.0
HKD2_k127_4597876_10 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005772 257.0
HKD2_k127_4597876_11 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000000000000000000000000005725 203.0
HKD2_k127_4597876_12 regulation of translation K01524,K03530,K04764,K05788 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000446 144.0
HKD2_k127_4597876_13 Putative ATP-dependant zinc protease - - - 0.00000000000000000000000000000001906 133.0
HKD2_k127_4597876_14 TIGRFAM competence damage-inducible protein CinA K03742,K03743 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 0.0000000000000000000000000000611 119.0
HKD2_k127_4597876_15 4Fe-4S binding domain - - - 0.000000000000002827 76.0
HKD2_k127_4597876_2 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 503.0
HKD2_k127_4597876_3 Cobalamin (Vitamin B12) biosynthesis CbiM protein K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009172 386.0
HKD2_k127_4597876_4 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 357.0
HKD2_k127_4597876_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 345.0
HKD2_k127_4597876_6 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 321.0
HKD2_k127_4597876_7 Mechanosensitive ion channel K03442 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 323.0
HKD2_k127_4597876_8 PFAM Phenazine biosynthesis PhzC PhzF protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 302.0
HKD2_k127_4597876_9 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 301.0
HKD2_k127_4602377_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 2.794e-296 919.0
HKD2_k127_4602377_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 1.245e-219 693.0
HKD2_k127_4602377_2 Protein of unknown function (DUF2950) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 331.0
HKD2_k127_4602377_3 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000476 261.0
HKD2_k127_4602377_4 Thrombomodulin like fifth domain, EGF-like K03907 GO:0000003,GO:0003674,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005886,GO:0005887,GO:0006950,GO:0007154,GO:0007165,GO:0007565,GO:0007596,GO:0007599,GO:0008150,GO:0009611,GO:0009986,GO:0009987,GO:0010543,GO:0010544,GO:0016020,GO:0016021,GO:0016327,GO:0022414,GO:0023052,GO:0030193,GO:0030194,GO:0030195,GO:0031090,GO:0031224,GO:0031226,GO:0032101,GO:0032102,GO:0032103,GO:0032501,GO:0038023,GO:0042060,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0044706,GO:0046872,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050817,GO:0050818,GO:0050819,GO:0050820,GO:0050865,GO:0050866,GO:0050878,GO:0050896,GO:0051239,GO:0051240,GO:0051241,GO:0051704,GO:0051716,GO:0051917,GO:0051918,GO:0060089,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0071944,GO:0080134,GO:0090303,GO:0098588,GO:0098590,GO:0098805,GO:1900046,GO:1900047,GO:1900048,GO:1903034,GO:1903035,GO:1903036 - 0.0002592 54.0
HKD2_k127_461076_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0 1106.0
HKD2_k127_461076_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 4.408e-278 858.0
HKD2_k127_461076_2 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 6.871e-217 687.0
HKD2_k127_461076_3 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 563.0
HKD2_k127_461076_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 415.0
HKD2_k127_461076_5 Aldo Keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003577 354.0
HKD2_k127_461076_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000000000004712 221.0
HKD2_k127_461076_7 HIT domain K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000006307 186.0
HKD2_k127_461076_8 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000005729 149.0
HKD2_k127_4620765_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.597e-227 725.0
HKD2_k127_4620765_1 type II secretion system K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 606.0
HKD2_k127_4620765_10 Prenyltransferase and squalene oxidase repeat - - - 0.000000000000000000000001161 114.0
HKD2_k127_4620765_2 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007735 538.0
HKD2_k127_4620765_3 PFAM PhoH family protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 511.0
HKD2_k127_4620765_4 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 458.0
HKD2_k127_4620765_5 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 302.0
HKD2_k127_4620765_6 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005214 283.0
HKD2_k127_4620765_7 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases. K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000001754 183.0
HKD2_k127_4620765_8 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000000000000000000000000000000000004629 165.0
HKD2_k127_4620765_9 ParB domain protein nuclease K03497 - - 0.0000000000000000000000005832 116.0
HKD2_k127_4638863_0 Rare lipoprotein A K20628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 291.0
HKD2_k127_4638863_1 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000001182 185.0
HKD2_k127_4638863_3 COG2303 Choline dehydrogenase and related flavoproteins K19813 - 1.1.5.9 0.000002203 59.0
HKD2_k127_4675449_0 TIGRFAM penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 1.166e-316 1000.0
HKD2_k127_4675449_1 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 524.0
HKD2_k127_468932_0 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 332.0
HKD2_k127_468932_1 Dihydroxyacetone kinase family - - - 0.0000000000000000000000000000000000000000000001584 179.0
HKD2_k127_468932_2 acyl-phosphate glycerol-3-phosphate acyltransferase activity K08591 - 2.3.1.15 0.00000000000000000000000000000000003884 139.0
HKD2_k127_470184_0 TIGRFAM aconitate hydratase K01681 - 4.2.1.3 2.239e-312 965.0
HKD2_k127_470184_1 Haem-binding uptake, Tiki superfamily, ChaN - - - 1.153e-236 769.0
HKD2_k127_470184_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 476.0
HKD2_k127_470184_3 Protein of unknown function (DUF1566) - - - 0.00000000000000000000000000000001159 128.0
HKD2_k127_4725201_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 2.573e-199 632.0
HKD2_k127_4725201_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000002166 202.0
HKD2_k127_4725201_2 4Fe-4S dicluster domain - - - 0.0000001422 54.0
HKD2_k127_4747488_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 2.219e-247 772.0
HKD2_k127_4747488_1 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 6.933e-235 749.0
HKD2_k127_4747488_10 Protein of unknown function (DUF533) - - - 0.0000000000000000000000000000006141 131.0
HKD2_k127_4747488_11 - - - - 0.0000000000000000000000000002055 121.0
HKD2_k127_4747488_2 Domain of unknown function (DUF3482) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 536.0
HKD2_k127_4747488_3 TIGRFAM TIGR00266 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 499.0
HKD2_k127_4747488_4 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008136 443.0
HKD2_k127_4747488_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 409.0
HKD2_k127_4747488_6 Protein of unknown function (DUF2868) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 354.0
HKD2_k127_4747488_7 Tellurite resistance protein TehB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001196 262.0
HKD2_k127_4747488_8 methyl-accepting chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001388 280.0
HKD2_k127_4747488_9 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000002565 173.0
HKD2_k127_4768933_0 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 3.053e-277 862.0
HKD2_k127_4768933_1 LeuA allosteric (dimerisation) domain K01649 - 2.3.3.13 5.027e-269 838.0
HKD2_k127_4768933_10 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000003354 249.0
HKD2_k127_4768933_12 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000006415 229.0
HKD2_k127_4768933_13 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000001855 218.0
HKD2_k127_4768933_15 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000006933 147.0
HKD2_k127_4768933_16 PFAM FeoA K04758 - - 0.00000000000000000000000000001635 121.0
HKD2_k127_4768933_17 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000002881 94.0
HKD2_k127_4768933_19 Ami_3 K01448 - 3.5.1.28 0.00001106 55.0
HKD2_k127_4768933_2 Rhodanese Homology Domain K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 483.0
HKD2_k127_4768933_3 PFAM SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 475.0
HKD2_k127_4768933_4 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 482.0
HKD2_k127_4768933_5 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 370.0
HKD2_k127_4768933_6 PFAM metal-dependent phosphohydrolase HD sub - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009408 334.0
HKD2_k127_4768933_7 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004749 328.0
HKD2_k127_4768933_8 cyclic nucleotide-binding K01420,K21563 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 297.0
HKD2_k127_4768933_9 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000003408 251.0
HKD2_k127_4804012_0 MBOAT, membrane-bound O-acyltransferase family K19294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 581.0
HKD2_k127_4804012_1 AsmA-like C-terminal region K07289 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003577 307.0
HKD2_k127_4804012_2 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.000000000000000000000000000000000000000000000000000000000002488 220.0
HKD2_k127_4819268_0 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 529.0
HKD2_k127_4819268_1 PFAM Rhodanese domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000443 259.0
HKD2_k127_4819268_2 thiosulfate sulfurtransferase activity - - - 0.00000000000000000000000000000000000000000000000000003893 194.0
HKD2_k127_4819268_3 DNA excision K02768,K02769,K02770,K02773,K02806,K03491 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015791,GO:0015796,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090584 2.7.1.200,2.7.1.202 0.0000000000000000000000000000000000000000000001534 176.0
HKD2_k127_4819268_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000007031 109.0
HKD2_k127_4831668_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009707 551.0
HKD2_k127_4831668_1 PFAM Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 429.0
HKD2_k127_4831668_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005981 318.0
HKD2_k127_4831668_3 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0008989 42.0
HKD2_k127_4838357_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00437,K05922,K06281 - 1.12.2.1,1.12.5.1,1.12.99.6 8.382e-309 952.0
HKD2_k127_4838357_1 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 3.209e-220 707.0
HKD2_k127_4838357_10 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000000000000000000000000001128 180.0
HKD2_k127_4838357_11 Ni Fe-hydrogenase, b-type cytochrome subunit K03620 - - 0.00000000000000000000000000000000000000000003427 164.0
HKD2_k127_4838357_12 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000009485 161.0
HKD2_k127_4838357_13 TonB C terminal K03646,K03832 - - 0.000000000000000000000000000000000000000008701 166.0
HKD2_k127_4838357_14 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000007591 57.0
HKD2_k127_4838357_2 Hydrogenase (NiFe) small subunit HydA K05927,K06282,K18008 - 1.12.2.1,1.12.5.1,1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 537.0
HKD2_k127_4838357_3 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 489.0
HKD2_k127_4838357_4 hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 428.0
HKD2_k127_4838357_5 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 402.0
HKD2_k127_4838357_6 PFAM MotA TolQ ExbB proton channel K03561,K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003493 282.0
HKD2_k127_4838357_7 PFAM ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000001103 263.0
HKD2_k127_4838357_8 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000002288 256.0
HKD2_k127_4838357_9 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000000000001121 249.0
HKD2_k127_4852203_0 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 559.0
HKD2_k127_4852203_1 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 294.0
HKD2_k127_4852203_2 TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002916 304.0
HKD2_k127_4852203_3 - - - - 0.000001301 51.0
HKD2_k127_4873761_0 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 384.0
HKD2_k127_4873761_1 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 374.0
HKD2_k127_4873761_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000002283 105.0
HKD2_k127_487489_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 3.243e-197 635.0
HKD2_k127_487489_1 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009942 416.0
HKD2_k127_487489_10 Tautomerase enzyme K01821 - 5.3.2.6 0.0000000000000004637 79.0
HKD2_k127_487489_12 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.0008714 46.0
HKD2_k127_487489_2 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 319.0
HKD2_k127_487489_3 ligase activity K05844 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008498 267.0
HKD2_k127_487489_4 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000005048 220.0
HKD2_k127_487489_5 TIGRFAM sulfur relay protein, TusE DsrC DsvC family K11179 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000001027 202.0
HKD2_k127_487489_6 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000000000000000000000000000000005323 158.0
HKD2_k127_487489_7 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000325 151.0
HKD2_k127_487489_9 Acylphosphatase K01512 - 3.6.1.7 0.000000000000000000007891 100.0
HKD2_k127_4883813_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 410.0
HKD2_k127_4883813_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005012 259.0
HKD2_k127_4883813_2 Domain of Unknown Function (DUF349) - - - 0.0000000000000000000000000000000000003159 157.0
HKD2_k127_4883813_3 Methyltransferase type 11 - - - 0.0002688 47.0
HKD2_k127_488522_0 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002193 260.0
HKD2_k127_488522_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000001949 201.0
HKD2_k127_4927957_0 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 610.0
HKD2_k127_4927957_1 Domain of unknown function (DUF2703) - - - 0.00000000000000000000000000004852 119.0
HKD2_k127_4952354_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12137 - - 3.735e-297 924.0
HKD2_k127_4952354_1 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 440.0
HKD2_k127_4952354_2 Ni-Fe hydrogenase, membrane subunit HyfE K12140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 333.0
HKD2_k127_4952354_3 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.0000000000000000000000000944 111.0
HKD2_k127_4952354_4 PFAM NADH Ubiquinone plastoquinone (complex I) K12141 - - 0.000000000000007573 88.0
HKD2_k127_4998944_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1606.0
HKD2_k127_4998944_1 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005088 336.0
HKD2_k127_5019874_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1538.0
HKD2_k127_5019874_1 4Fe-4S dicluster domain - - - 4.253e-256 812.0
HKD2_k127_5019874_2 Methyl-viologen-reducing hydrogenase, delta subunit K14127 - 1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000005613 201.0
HKD2_k127_5019874_3 SMART Integrin alpha beta-propellor repeat protein - - - 0.0000000000000000000000000001278 130.0
HKD2_k127_5040937_0 sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 500.0
HKD2_k127_5040937_1 NADPH-dependent FMN reductase K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 307.0
HKD2_k127_5040937_2 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000006101 196.0
HKD2_k127_5040937_3 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000001672 166.0
HKD2_k127_5040937_4 PFAM response regulator receiver K02485,K11355 - - 0.00000000000000000000000000000004508 130.0
HKD2_k127_5040937_5 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.00000000000000000005449 103.0
HKD2_k127_5046697_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 5.363e-201 637.0
HKD2_k127_5046697_1 von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 610.0
HKD2_k127_5046697_2 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009683 553.0
HKD2_k127_5046697_3 ABC transporter transmembrane region K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008247 482.0
HKD2_k127_5046697_4 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 376.0
HKD2_k127_5046697_5 AIR synthase related protein, N-terminal domain K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 366.0
HKD2_k127_5046697_6 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000944 269.0
HKD2_k127_5046697_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000005103 154.0
HKD2_k127_5062551_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 479.0
HKD2_k127_5062551_1 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007619 327.0
HKD2_k127_5062551_2 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000005532 120.0
HKD2_k127_5073784_0 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 321.0
HKD2_k127_5073784_1 - - - - 0.000000000000000000000000000000000000000000000000000003552 202.0
HKD2_k127_5073784_2 secretion protein HlyD family K03543 - - 0.00000000000007929 75.0
HKD2_k127_5081738_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 1.799e-205 646.0
HKD2_k127_5081738_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 429.0
HKD2_k127_5081738_2 PFAM HPP family K07168 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 305.0
HKD2_k127_5081738_3 PFAM HhH-GPD family protein K07457 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003655 272.0
HKD2_k127_5081738_4 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000001484 210.0
HKD2_k127_5081738_5 Belongs to the HesB IscA family - - - 0.0000000000000000000000000004554 114.0
HKD2_k127_5081738_6 Divergent 4Fe-4S mono-cluster K05337 - - 0.00000000000002064 73.0
HKD2_k127_5081738_7 PilZ domain - - - 0.0000009294 58.0
HKD2_k127_5081738_8 Belongs to the HesB IscA family - - - 0.00001098 48.0
HKD2_k127_508764_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 9.981e-249 781.0
HKD2_k127_508764_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007654 440.0
HKD2_k127_508764_2 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000000000001913 231.0
HKD2_k127_508764_3 O-Antigen ligase K02847 - - 0.00000000000000000000000000000000000007162 158.0
HKD2_k127_508764_4 - - - - 0.0000000000000000000000004303 115.0
HKD2_k127_508764_5 PFAM O-Antigen K18814 - - 0.0000000000000008879 88.0
HKD2_k127_508764_6 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000006127 58.0
HKD2_k127_5095766_0 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 524.0
HKD2_k127_5095766_1 Sigma-54 interaction domain K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 377.0
HKD2_k127_5095766_2 Signal Transduction Histidine Kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005415 344.0
HKD2_k127_5095766_3 PFAM Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 351.0
HKD2_k127_5095766_4 PFAM response regulator receiver K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 320.0
HKD2_k127_5096980_0 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006057 291.0
HKD2_k127_5096980_1 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001729 246.0
HKD2_k127_5096980_2 - - - - 0.000000000000000000000000000000006109 133.0
HKD2_k127_5096980_3 Tetratricopeptide repeat - - - 0.00000000000000004855 86.0
HKD2_k127_5110009_0 TIGRFAM glutaminyl-tRNA synthetase K01886 - 6.1.1.18 1.053e-299 925.0
HKD2_k127_5110009_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 4.07e-263 818.0
HKD2_k127_5110009_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 9.376e-242 754.0
HKD2_k127_5110009_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 511.0
HKD2_k127_5110009_4 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000008574 209.0
HKD2_k127_5110009_5 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000000001761 195.0
HKD2_k127_5110009_6 Domain of unknown function (DUF1844) - - - 0.0000000000000000000000000000000001373 135.0
HKD2_k127_5110009_7 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000009485 69.0
HKD2_k127_5113763_0 Doubled CXXCH motif (Paired_CXXCH_1) - - - 1.863e-210 670.0
HKD2_k127_5146567_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1041.0
HKD2_k127_5146567_1 Region found in RelA / SpoT proteins K00951 - 2.7.6.5 8.35e-322 997.0
HKD2_k127_5146567_10 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 286.0
HKD2_k127_5146567_11 PFAM ABC transporter K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004511 283.0
HKD2_k127_5146567_12 ABC 3 transport family K09816,K09819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001212 260.0
HKD2_k127_5146567_13 PFAM YsiA-like protein, C-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007636 253.0
HKD2_k127_5146567_14 PFAM CMP dCMP deaminase zinc-binding K11991 - 3.5.4.33 0.000000000000000000000000000000000000000000000000000000000002065 215.0
HKD2_k127_5146567_15 - - - - 0.000000000000000000000000000000000000000000000000000000000009314 211.0
HKD2_k127_5146567_16 Regulatory protein, FmdB family - - - 0.0000000000000000000000000000000000000000000000000000004863 197.0
HKD2_k127_5146567_17 protein conserved in bacteria K09793 - - 0.00000000000000000000000000000000000000000004059 165.0
HKD2_k127_5146567_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 - - 0.000000000000000000007518 97.0
HKD2_k127_5146567_2 sulfate adenylyltransferase K00958,K13811 - 2.7.1.25,2.7.7.4 1.574e-239 745.0
HKD2_k127_5146567_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 1.519e-228 730.0
HKD2_k127_5146567_4 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005449 533.0
HKD2_k127_5146567_5 PFAM Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 505.0
HKD2_k127_5146567_6 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 465.0
HKD2_k127_5146567_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 419.0
HKD2_k127_5146567_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 315.0
HKD2_k127_5146567_9 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 - 2.1.1.200 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 312.0
HKD2_k127_5167802_0 Protease prsW family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004013 281.0
HKD2_k127_5167802_1 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.000000000000000000001549 101.0
HKD2_k127_5170890_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 400.0
HKD2_k127_5170890_1 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000001526 217.0
HKD2_k127_5223769_0 DnaJ molecular chaperone homology domain K05516 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008794 447.0
HKD2_k127_5223769_1 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000001914 149.0
HKD2_k127_5223769_2 MerR HTH family regulatory protein K18997 - - 0.00000000000000000000000000000006594 126.0
HKD2_k127_5259847_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 0.0 1112.0
HKD2_k127_5259847_1 LssY C-terminus - - - 6.677e-229 729.0
HKD2_k127_5259847_2 PFAM surface antigen (D15) K07277,K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 526.0
HKD2_k127_5259847_3 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 424.0
HKD2_k127_5259847_4 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000003085 121.0
HKD2_k127_5259847_5 inositol 2-dehydrogenase activity - - - 0.0000000000000000000001166 100.0
HKD2_k127_5301958_0 PFAM homoserine dehydrogenase K00003 - 1.1.1.3 8.705e-197 623.0
HKD2_k127_5301958_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002887 391.0
HKD2_k127_5301958_2 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 365.0
HKD2_k127_5326056_0 Fimbrial assembly family protein K02461 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000629 276.0
HKD2_k127_5326056_1 General secretion pathway protein K K02460 - - 0.00000000000000000000000000000000000000000000000000000000000000000001392 244.0
HKD2_k127_5326056_2 Type II secretion system (T2SS), protein M K02462 - - 0.0000000000000000000000000005154 125.0
HKD2_k127_5326056_3 - - - - 0.0000000005007 70.0
HKD2_k127_5382257_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 379.0
HKD2_k127_5382257_1 iron ion homeostasis K03709,K04758 - - 0.0000000000000000000000000000000000000000000001135 175.0
HKD2_k127_5389485_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 550.0
HKD2_k127_5389485_1 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 383.0
HKD2_k127_5389485_2 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 346.0
HKD2_k127_5389485_3 - - - - 0.000000000000000000000000000000000005651 138.0
HKD2_k127_5389485_4 - - - - 0.000001052 51.0
HKD2_k127_5390361_0 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004298 319.0
HKD2_k127_5390361_1 SLBB domain K02237 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000004898 63.0
HKD2_k127_5397962_0 metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 492.0
HKD2_k127_5397962_1 Transcriptional regulator, LysR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 348.0
HKD2_k127_5397962_2 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD K03581 - 3.1.11.5 0.00000000000000000000000000000000000000000000000000000004767 202.0
HKD2_k127_5397962_3 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000000003002 118.0
HKD2_k127_5397962_4 Cupin 2, conserved barrel domain protein - - - 0.00000000000005085 72.0
HKD2_k127_5436287_0 Catalyzes the synthesis of activated sulfate K00958 - 2.7.7.4 2.002e-283 882.0
HKD2_k127_5436287_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.204e-280 882.0
HKD2_k127_5436287_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 2.359e-219 686.0
HKD2_k127_5436287_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 551.0
HKD2_k127_5436287_4 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007341 340.0
HKD2_k127_5436287_5 - - - - 0.000000000000000000000000000000000000000000001226 171.0
HKD2_k127_5436287_6 - - - - 0.00000000000001141 75.0
HKD2_k127_5436287_7 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000001685 72.0
HKD2_k127_5436287_8 orotate phosphoribosyltransferase activity K00762 - 2.4.2.10 0.0000002071 58.0
HKD2_k127_5436287_9 glycyl-tRNA synthetase, beta K01879 - 6.1.1.14 0.000003682 48.0
HKD2_k127_547232_0 Lytic transglycosylase catalytic K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 552.0
HKD2_k127_547232_1 His Kinase A (phosphoacceptor) domain K02668,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004231 533.0
HKD2_k127_547232_2 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 503.0
HKD2_k127_547232_3 protein trimerization K07114,K08309 - - 0.000000000000000000000000000000000000000000000324 181.0
HKD2_k127_547232_4 CRS1_YhbY K07574 - - 0.000000000000000000000000002168 114.0
HKD2_k127_547232_5 TIGRFAM penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.00000000003725 65.0
HKD2_k127_5486243_0 Nucleoside recognition - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 483.0
HKD2_k127_5486243_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 389.0
HKD2_k127_5486243_2 Domains REC, HisKA, HATPase_c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008482 340.0
HKD2_k127_5486243_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000007865 239.0
HKD2_k127_5486243_4 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000266 121.0
HKD2_k127_5486243_5 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00001289 53.0
HKD2_k127_5506241_0 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 410.0
HKD2_k127_5506241_2 surface antigen - - - 0.0000000000000000000000000000547 128.0
HKD2_k127_5528011_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 584.0
HKD2_k127_5528011_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 562.0
HKD2_k127_5528011_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 529.0
HKD2_k127_5528011_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 461.0
HKD2_k127_5541322_0 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006749 601.0
HKD2_k127_5541322_1 sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007523 474.0
HKD2_k127_5546902_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1433.0
HKD2_k127_5546902_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1091.0
HKD2_k127_5546902_2 peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 324.0
HKD2_k127_5546902_3 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K20881 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 289.0
HKD2_k127_5546902_4 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000002787 259.0
HKD2_k127_5546902_5 Protein conserved in bacteria K15539 - - 0.00000000000000000000000000000000003254 148.0
HKD2_k127_5565908_0 PFAM aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 605.0
HKD2_k127_5565908_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000001464 212.0
HKD2_k127_5565908_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000001656 90.0
HKD2_k127_5589917_0 TIGRFAM DNA topoisomerase III, bacteria and conjugative plasmid K03169 - 5.99.1.2 0.0 1177.0
HKD2_k127_5589917_1 TIGRFAM Threonine synthase K01733 - 4.2.3.1 1.852e-205 647.0
HKD2_k127_5589917_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 1.773e-194 622.0
HKD2_k127_5589917_3 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 9.629e-194 613.0
HKD2_k127_5589917_4 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006215 346.0
HKD2_k127_5589917_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000000000000000000000000387 194.0
HKD2_k127_5624882_0 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000148 287.0
HKD2_k127_5624882_1 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000004314 162.0
HKD2_k127_5644255_0 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 543.0
HKD2_k127_5644255_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 505.0
HKD2_k127_5644255_2 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 299.0
HKD2_k127_5644255_3 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.000000000000000000000000000000000000000000000000000000000004901 210.0
HKD2_k127_56498_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 3.285e-211 662.0
HKD2_k127_56498_1 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 550.0
HKD2_k127_56498_10 Protein of unknown function (DUF523) - - - 0.000000000000000000000000000000000000001312 153.0
HKD2_k127_56498_11 - - - - 0.00000000000000000000000000000001131 143.0
HKD2_k127_56498_12 Late embryogenesis abundant protein - - - 0.000000000000000000000000000001104 127.0
HKD2_k127_56498_13 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000004071 105.0
HKD2_k127_56498_14 Protein conserved in bacteria - - - 0.000000000000002231 87.0
HKD2_k127_56498_16 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589,K13052 - - 0.00000000002823 68.0
HKD2_k127_56498_17 - - - - 0.00000002178 64.0
HKD2_k127_56498_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 441.0
HKD2_k127_56498_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004174 439.0
HKD2_k127_56498_4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005335 427.0
HKD2_k127_56498_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004547 426.0
HKD2_k127_56498_6 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 355.0
HKD2_k127_56498_7 TIGRFAM tyrosine recombinase XerD K03733,K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 318.0
HKD2_k127_56498_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002804 280.0
HKD2_k127_56498_9 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000001502 164.0
HKD2_k127_5711522_0 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 566.0
HKD2_k127_5711522_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 434.0
HKD2_k127_5731448_0 Uncharacterized protein conserved in bacteria (DUF2087) - - - 0.00000000000000000000000000000000000000000000007296 174.0
HKD2_k127_5731448_1 PFAM Abortive infection protein K07052 - - 0.00000000000000000125 97.0
HKD2_k127_573976_0 cyclic nucleotide binding K10914 - - 0.000000000000000000000000000000000000000000000000000001067 199.0
HKD2_k127_573976_1 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000006663 136.0
HKD2_k127_573976_3 PFAM Ubiquitin-conjugating - - - 0.0000000000000000000000000000001048 127.0
HKD2_k127_5742015_0 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 375.0
HKD2_k127_5742015_1 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 356.0
HKD2_k127_5783407_0 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 5.505e-221 694.0
HKD2_k127_5783407_1 MGS-like domain K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 322.0
HKD2_k127_5783407_2 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 317.0
HKD2_k127_5783407_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009837 288.0
HKD2_k127_5783407_4 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000003677 248.0
HKD2_k127_5783407_5 S4 RNA-binding domain K04762 GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.00000000000000000000000000000001277 131.0
HKD2_k127_5783407_7 PFAM ATP-binding region, ATPase domain protein - - - 0.0000000000000000000005335 99.0
HKD2_k127_5804316_0 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 4.321e-292 911.0
HKD2_k127_5804316_1 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 372.0
HKD2_k127_5804316_2 PFAM CBS domain K04767 - - 0.00000000000000000000000000000000000000000000000000000000000003815 221.0
HKD2_k127_5804316_3 NosL - - - 0.000000000000000000000000000000000000000000000000000000000001905 225.0
HKD2_k127_5804316_4 PFAM Acetyl-CoA hydrolase transferase - - - 0.00000000000000000000000000001312 127.0
HKD2_k127_5804316_6 cell redox homeostasis K03671 - - 0.00000000001693 70.0
HKD2_k127_5817198_0 PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit K14138 - 2.3.1.169 0.0 1317.0
HKD2_k127_5817198_1 TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 0.0 1116.0
HKD2_k127_5817198_2 PFAM Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.0 1116.0
HKD2_k127_5817198_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 490.0
HKD2_k127_5817198_4 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 310.0
HKD2_k127_5817198_5 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 285.0
HKD2_k127_5817198_6 ribonuclease Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000142 127.0
HKD2_k127_5817745_0 PFAM Radical SAM - - - 3.508e-235 740.0
HKD2_k127_5817745_1 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000000000000000000000000000000000000000003575 188.0
HKD2_k127_5817745_2 PFAM Carboxymuconolactone decarboxylase - - - 0.000000000000000000000000000000000006491 141.0
HKD2_k127_5817745_3 radical SAM K04034 - 1.21.98.3 0.000000000000000009459 89.0
HKD2_k127_5817745_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000005412 77.0
HKD2_k127_5839447_0 Peptidase M16C associated K06972 - - 0.0 1176.0
HKD2_k127_5839447_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 607.0
HKD2_k127_5839447_10 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000007589 195.0
HKD2_k127_5839447_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000001974 171.0
HKD2_k127_5839447_12 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000000000000000000000000136 169.0
HKD2_k127_5839447_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006552 562.0
HKD2_k127_5839447_3 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 569.0
HKD2_k127_5839447_4 AAA ATPase, central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 473.0
HKD2_k127_5839447_5 PFAM CobQ CobB MinD ParA nucleotide binding domain K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 347.0
HKD2_k127_5839447_6 TIGRFAM competence damage-inducible protein CinA K03742,K03743 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 336.0
HKD2_k127_5839447_7 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000001192 224.0
HKD2_k127_5839447_8 - - - - 0.000000000000000000000000000000000000000000000000000000001095 212.0
HKD2_k127_5839447_9 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000000000002817 191.0
HKD2_k127_5862580_0 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 5.805e-264 834.0
HKD2_k127_5862580_1 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 6.534e-240 759.0
HKD2_k127_5862580_2 Transglycosylase SLT domain K08305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 408.0
HKD2_k127_5862580_3 3'(2'),5'-bisphosphate nucleotidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 367.0
HKD2_k127_5862580_4 PFAM Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 328.0
HKD2_k127_5862580_5 Sodium:solute symporter family K14393 - - 0.0000000000000000006816 87.0
HKD2_k127_5862580_6 - - - - 0.00005736 46.0
HKD2_k127_5873156_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 539.0
HKD2_k127_5873156_1 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K04488,K13819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005188 308.0
HKD2_k127_5903132_0 ABC transporter K06158 - - 1.657e-281 872.0
HKD2_k127_5903132_1 Sugar transferase K03606 - - 1.071e-207 657.0
HKD2_k127_5903132_2 DHHA2 K15986 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 512.0
HKD2_k127_5903132_3 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005312 489.0
HKD2_k127_5903132_4 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 489.0
HKD2_k127_5903132_5 Belongs to the BI1 family K06890,K19416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007353 339.0
HKD2_k127_5903132_6 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 325.0
HKD2_k127_5903132_8 Cytochrome c554 and c-prime - - - 0.000005803 58.0
HKD2_k127_5925096_0 PFAM Major Facilitator Superfamily K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 554.0
HKD2_k127_5925096_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 389.0
HKD2_k127_5925096_2 A G-specific adenine glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006443 383.0
HKD2_k127_5925096_3 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000004427 108.0
HKD2_k127_5958682_0 Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0 1543.0
HKD2_k127_5963455_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 5.505e-267 831.0
HKD2_k127_5963455_1 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005062 308.0
HKD2_k127_5980485_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009266 520.0
HKD2_k127_5980485_1 PFAM peptidase S8 and S53 subtilisin kexin sedolisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 448.0
HKD2_k127_5980485_2 Transmembrane protein 43 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 416.0
HKD2_k127_5980485_3 UV-endonuclease UvdE K13281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009069 329.0
HKD2_k127_5980485_4 - - - - 0.00000000000000000000000000000000000000000001911 165.0
HKD2_k127_6009144_0 PFAM Phosphomethylpyrimidine kinase K00941,K14153,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000181 201.0
HKD2_k127_6009144_1 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000006868 188.0
HKD2_k127_6011731_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 4.798e-248 769.0
HKD2_k127_6011731_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000002687 241.0
HKD2_k127_6011731_2 - - - - 0.0000000000000002663 87.0
HKD2_k127_6030715_0 Glycosyltransferase like family 2 K10012 - 2.4.2.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 447.0
HKD2_k127_6030715_1 PFAM Glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 380.0
HKD2_k127_6070613_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 1.817e-313 984.0
HKD2_k127_6070613_1 PFAM Glutamine synthetase, catalytic K01915 - 6.3.1.2 6.922e-229 713.0
HKD2_k127_6070613_2 TIGRFAM ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 590.0
HKD2_k127_6070613_3 nitrogen regulatory protein P-II K04751 - - 0.000000000000000000000000000000000000000000000000007587 182.0
HKD2_k127_6127440_0 PAS domain containing protein K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 501.0
HKD2_k127_6127440_1 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 455.0
HKD2_k127_6127440_2 Cysteine-rich domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 345.0
HKD2_k127_6127440_3 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000001054 229.0
HKD2_k127_6142920_0 PFAM peptidase K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000188 290.0
HKD2_k127_6142920_1 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000001901 209.0
HKD2_k127_6142920_2 AsmA-like C-terminal region - - - 0.000000000000000000000000000000000000000000007571 179.0
HKD2_k127_6142920_3 Class III cytochrome C family - - - 0.0000009629 57.0
HKD2_k127_6155697_0 Phosphofructokinase K00850 - 2.7.1.11 2.501e-197 622.0
HKD2_k127_6155697_1 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 562.0
HKD2_k127_6155697_2 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003417 339.0
HKD2_k127_6155697_3 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000007372 261.0
HKD2_k127_6155697_4 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14128 - 1.8.98.5 0.000000000000000000000000000000000000025 153.0
HKD2_k127_6165509_0 Prokaryotic cytochrome b561 K00127 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 319.0
HKD2_k127_6165509_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000003979 85.0
HKD2_k127_6200437_0 Belongs to the UbiD family K03182 - 4.1.1.98 4.157e-306 945.0
HKD2_k127_6200437_1 Belongs to the pseudouridine synthase RsuA family K06178,K06182 - 5.4.99.21,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 316.0
HKD2_k127_6200437_2 Glycine zipper 2TM domain - - - 0.00000000000000000000000000000000000000000000000001118 182.0
HKD2_k127_6200437_3 TIGRFAM secondary thiamine-phosphate synthase enzyme - - - 0.000000000000000000000000000000000000000000000002613 181.0
HKD2_k127_6200437_4 - - - - 0.00000000000001479 78.0
HKD2_k127_620716_0 PFAM peptidase M24 K01262,K01271 - 3.4.11.9,3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 505.0
HKD2_k127_620716_1 pfam abc K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 390.0
HKD2_k127_620716_11 Uncharacterized conserved protein (DUF2196) - - - 0.00000000000000000000015 98.0
HKD2_k127_620716_12 part of a sulfur-relay system - - - 0.00000000001114 69.0
HKD2_k127_620716_13 COG3209 Rhs family protein - - - 0.000000002609 68.0
HKD2_k127_620716_14 PFAM AhpC TSA family K03386 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0001847 45.0
HKD2_k127_620716_2 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 381.0
HKD2_k127_620716_3 PFAM Fe-S cluster domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000521 313.0
HKD2_k127_620716_4 phosphoesterases, related to the Icc protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003436 270.0
HKD2_k127_620716_5 Belongs to the UPF0178 family K09768 - - 0.000000000000000000000000000000000000000000000000000000002734 203.0
HKD2_k127_620716_6 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.000000000000000000000000000000000007491 140.0
HKD2_k127_620716_7 peptidyl-prolyl cis-trans isomerase - - - 0.0000000000000000000000000000000001281 137.0
HKD2_k127_620716_8 AhpC/TSA family K03564 - 1.11.1.15 0.000000000000000000000000000000002564 131.0
HKD2_k127_620716_9 Protein of unknown function (DUF1186) - - - 0.00000000000000000000000001812 118.0
HKD2_k127_6223090_0 RESPONSE REGULATOR receiver K13490 - - 4.435e-243 784.0
HKD2_k127_6223090_1 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 418.0
HKD2_k127_6223090_10 PFAM Cold-shock K03704 - - 0.000000000000000000000000000000005154 128.0
HKD2_k127_6223090_11 Two component signalling adaptor domain K13488 - - 0.000000000000000000000000000001079 126.0
HKD2_k127_6223090_2 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain K07315,K11444 - 2.7.7.65,3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 369.0
HKD2_k127_6223090_3 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13491 - 3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 338.0
HKD2_k127_6223090_4 chemotaxis K13487 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 336.0
HKD2_k127_6223090_5 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 313.0
HKD2_k127_6223090_6 Methyltransferase, chemotaxis proteins K00575,K13486 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006038 291.0
HKD2_k127_6223090_7 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000004956 246.0
HKD2_k127_6223090_8 Bacterial SH3 domain homologues K07184 - - 0.00000000000000000000000000000000000000156 156.0
HKD2_k127_6223090_9 Two component signalling adaptor domain K13489 - - 0.00000000000000000000000000000000004936 143.0
HKD2_k127_6238655_0 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 386.0
HKD2_k127_6238655_1 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007607 321.0
HKD2_k127_6238655_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000003537 236.0
HKD2_k127_6238655_3 SAM-dependent RNA methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000002987 229.0
HKD2_k127_6238655_4 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000006926 198.0
HKD2_k127_6238655_5 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000011 138.0
HKD2_k127_6238655_6 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000002675 115.0
HKD2_k127_6238655_7 Belongs to the UPF0109 family K06960 - - 0.000000000000001237 77.0
HKD2_k127_6250455_0 Haloacid dehalogenase-like hydrolase - - - 2.92e-287 903.0
HKD2_k127_6250455_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000006772 234.0
HKD2_k127_6250455_2 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000001704 75.0
HKD2_k127_6256916_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.506e-220 694.0
HKD2_k127_6256916_1 PFAM Iron-containing alcohol dehydrogenase K00001,K19954 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 551.0
HKD2_k127_6256916_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 384.0
HKD2_k127_6256916_3 TIGRFAM hydrolase, TatD family K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 300.0
HKD2_k127_6256916_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000004289 244.0
HKD2_k127_6256916_5 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000006826 221.0
HKD2_k127_6256916_6 Domain of unknown function (DUF296) - - - 0.000000000000000000000000000000000000000000000000000000445 196.0
HKD2_k127_6256916_8 Protein of unknown function (DUF615) K09889 - - 0.0000000000000000000000000000000000000006347 155.0
HKD2_k127_6256916_9 - - - - 0.00000000000000000000000000001097 121.0
HKD2_k127_6371917_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009951 397.0
HKD2_k127_6371917_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 392.0
HKD2_k127_6371917_2 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.00000000000000000000000000000000000000000000000001033 184.0
HKD2_k127_6371917_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000344 92.0
HKD2_k127_6384817_0 RNA-metabolising metallo-beta-lactamase K07576 - - 3.7e-207 657.0
HKD2_k127_6384817_1 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006732 458.0
HKD2_k127_6384817_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 310.0
HKD2_k127_6384817_3 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008355 284.0
HKD2_k127_6384817_4 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000007742 213.0
HKD2_k127_6384817_5 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00003,K00982,K00990,K06950,K15371 - 1.1.1.3,1.4.1.2,2.7.7.42,2.7.7.59,2.7.7.89 0.0000000000000000000000000000000000000000000005994 178.0
HKD2_k127_6394425_0 PFAM glycosyl transferase family 2 K20444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000966 367.0
HKD2_k127_6394425_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 338.0
HKD2_k127_6404755_0 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 361.0
HKD2_k127_6404755_1 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000002259 204.0
HKD2_k127_6404755_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000002311 93.0
HKD2_k127_6407668_0 E1-E2 ATPase K17686 - 3.6.3.54 0.0 1020.0
HKD2_k127_6407668_1 Protein of unknown function (DUF2867) - - - 5.015e-212 671.0
HKD2_k127_6407668_2 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009612 384.0
HKD2_k127_6407668_3 Curli production assembly transport component CsgG - - - 0.0000000000000000000000000000000000004739 153.0
HKD2_k127_6407668_4 MerR, DNA binding K19591 - - 0.0000000000000000000000000007069 119.0
HKD2_k127_6407668_5 DsrE/DsrF-like family - - - 0.000000000008116 70.0
HKD2_k127_6407668_6 coenzyme F420 binding K00275 - 1.4.3.5 0.0000005975 53.0
HKD2_k127_6424785_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 1.129e-249 782.0
HKD2_k127_6424785_1 TIGRFAM lipopolysaccharide heptosyltransferase II K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 400.0
HKD2_k127_6424785_2 Bacterial extracellular solute-binding proteins, family 5 Middle K13893 - - 0.000000000000000000000000000000000000000000000000000001834 193.0
HKD2_k127_6424785_3 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000000000000000000632 154.0
HKD2_k127_6443955_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 578.0
HKD2_k127_6443955_1 Amidohydrolase family K05603 - 3.5.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 467.0
HKD2_k127_6443955_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 313.0
HKD2_k127_6443955_3 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.000000000000000000000000000000000000000000000000000002495 196.0
HKD2_k127_6443955_4 Gram-negative-bacterium-type cell outer membrane assembly - - - 0.0000000000000000000000000000000002383 138.0
HKD2_k127_6449324_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1250.0
HKD2_k127_6449324_1 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 1.787e-268 843.0
HKD2_k127_6449324_10 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000001218 201.0
HKD2_k127_6449324_11 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.000000000000000000000000000000000000000000000002536 179.0
HKD2_k127_6449324_12 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000647 166.0
HKD2_k127_6449324_13 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000002896 163.0
HKD2_k127_6449324_14 Predicted membrane protein (DUF2232) - - - 0.00000000000000000000000000000000000000002189 165.0
HKD2_k127_6449324_15 PFAM MazG nucleotide pyrophosphohydrolase K02499,K04765 - 3.6.1.9 0.0000000000000000000000000000000001456 137.0
HKD2_k127_6449324_16 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000006658 111.0
HKD2_k127_6449324_18 - - - - 0.0000000000000000000003745 98.0
HKD2_k127_6449324_19 - - - - 0.0000000000001698 83.0
HKD2_k127_6449324_2 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 2.561e-208 662.0
HKD2_k127_6449324_20 Zinc metalloprotease (Elastase) K09607 - - 0.00000001262 67.0
HKD2_k127_6449324_3 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 603.0
HKD2_k127_6449324_4 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 485.0
HKD2_k127_6449324_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007101 355.0
HKD2_k127_6449324_6 Exopolysaccharide production protein ExoZ - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004817 330.0
HKD2_k127_6449324_7 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 287.0
HKD2_k127_6449324_8 PFAM Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002097 260.0
HKD2_k127_6449324_9 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000001178 231.0
HKD2_k127_6473713_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 2.644e-207 651.0
HKD2_k127_6473713_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 321.0
HKD2_k127_6473713_2 PFAM MltA K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 292.0
HKD2_k127_6473713_3 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000003122 202.0
HKD2_k127_6473713_4 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000000000000000000007179 192.0
HKD2_k127_6473713_5 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000006194 94.0
HKD2_k127_6473713_6 domain protein K12516 - - 0.000000000000000000008792 106.0
HKD2_k127_6473713_7 Lamin Tail Domain - - - 0.00000000000005064 84.0
HKD2_k127_6473713_8 Domain of unknown function DUF11 - - - 0.0004258 52.0
HKD2_k127_6517867_0 Belongs to the beta-ketoacyl-ACP synthases family K00647 - 2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 576.0
HKD2_k127_6517867_1 Enoyl-(Acyl carrier protein) reductase K16066 - 1.1.1.381 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 347.0
HKD2_k127_6517867_2 cyclic nucleotide binding K10914 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007704 249.0
HKD2_k127_6517867_3 Iron-storage protein K02217 - 1.16.3.2 0.0000000000000000000000000000000000000000000000000000000000000000001255 235.0
HKD2_k127_6517867_4 PFAM CMP dCMP deaminase zinc-binding K01487 - 3.5.4.3 0.0000000000000000000000000000000000000000000001303 174.0
HKD2_k127_6517867_5 lyase activity - - - 0.00000000000000000000000000000000000000000000738 168.0
HKD2_k127_653512_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1420.0
HKD2_k127_653512_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 3.937e-216 676.0
HKD2_k127_653512_10 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 390.0
HKD2_k127_653512_11 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 350.0
HKD2_k127_653512_12 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008041 325.0
HKD2_k127_653512_13 PFAM ThiJ PfpI domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007965 315.0
HKD2_k127_653512_14 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 312.0
HKD2_k127_653512_15 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008158 308.0
HKD2_k127_653512_16 4Fe-4S dicluster domain K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 299.0
HKD2_k127_653512_17 Belongs to the SfsA family K06206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 287.0
HKD2_k127_653512_18 PFAM Pilus assembly protein PilO K02664 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003889 243.0
HKD2_k127_653512_19 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000000000000000000000000000000000000000000165 229.0
HKD2_k127_653512_2 Bacterial type II and III secretion system protein K12282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 589.0
HKD2_k127_653512_20 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000003781 209.0
HKD2_k127_653512_21 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000000008389 202.0
HKD2_k127_653512_22 Integrase core domain - - - 0.00000000000000000000000000000000000000000001617 163.0
HKD2_k127_653512_23 PFAM Fimbrial assembly K02663 - - 0.00000000000000000000000000000000000000000343 162.0
HKD2_k127_653512_24 CoA-binding domain protein K06929 - - 0.000000000000000000000000000000000000000008357 158.0
HKD2_k127_653512_25 PFAM Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000000000000001051 134.0
HKD2_k127_653512_26 Pilus assembly protein, PilP K02664,K02665 - - 0.00000000000000000000000000000001506 135.0
HKD2_k127_653512_27 PFAM Integrase catalytic region K07497 GO:0008150,GO:0009987,GO:0032196 - 0.000000000000000000007734 92.0
HKD2_k127_653512_28 beta-galactosidase activity K01190,K01197,K01206,K17624 - 3.2.1.23,3.2.1.35,3.2.1.51,3.2.1.97 0.0000000000000003562 91.0
HKD2_k127_653512_3 PFAM glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 550.0
HKD2_k127_653512_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 552.0
HKD2_k127_653512_5 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009762 548.0
HKD2_k127_653512_6 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008685 473.0
HKD2_k127_653512_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 455.0
HKD2_k127_653512_8 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 421.0
HKD2_k127_653512_9 Methylene-tetrahydrofolate reductase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008054 387.0
HKD2_k127_6536483_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1347.0
HKD2_k127_6536483_1 ribonuclease Rne Rng family K08301 - - 4.649e-195 617.0
HKD2_k127_6536483_2 permease YjgP YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 550.0
HKD2_k127_6536483_3 PFAM peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 514.0
HKD2_k127_6536483_4 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 509.0
HKD2_k127_6536483_5 Biotin-lipoyl like K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 368.0
HKD2_k127_6536483_6 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000171 279.0
HKD2_k127_6547582_0 Alanine dehydrogenase/PNT, N-terminal domain K00290,K14157 - 1.5.1.7,1.5.1.8,1.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 524.0
HKD2_k127_6547582_1 Saccharopine dehydrogenase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 491.0
HKD2_k127_6547582_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 453.0
HKD2_k127_6547582_3 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369,K13890 - - 0.00000000000000000000000000000000000000000000000001441 180.0
HKD2_k127_6547582_4 Pfam GAF - - - 0.0009967 46.0
HKD2_k127_6597323_0 Signal transducing histidine kinase, homodimeric K03407 - 2.7.13.3 2.747e-218 702.0
HKD2_k127_6597323_1 Response regulator receiver domain K03413 - - 0.0000000000000000000000000000000000000000000009268 168.0
HKD2_k127_6597323_2 Two component signalling adaptor domain K03408 - - 0.000000000000000000000008842 104.0
HKD2_k127_6610485_0 4 iron, 4 sulfur cluster binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 321.0
HKD2_k127_6610485_1 BadF BadG BcrA BcrD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 295.0
HKD2_k127_6620460_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 1.178e-223 697.0
HKD2_k127_6620460_1 TIGRFAM argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 3.361e-215 682.0
HKD2_k127_6620460_10 TIGRFAM acetylornithine and succinylornithine K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000006355 249.0
HKD2_k127_6620460_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000007781 238.0
HKD2_k127_6620460_12 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000000000000284 207.0
HKD2_k127_6620460_13 PFAM Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000005063 169.0
HKD2_k127_6620460_14 TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000000002916 150.0
HKD2_k127_6620460_15 monooxygenase activity - - - 0.0000000000000000003475 90.0
HKD2_k127_6620460_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005903 595.0
HKD2_k127_6620460_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 449.0
HKD2_k127_6620460_4 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 438.0
HKD2_k127_6620460_5 Dihydrodipicolinate reductase, C-terminus K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 421.0
HKD2_k127_6620460_6 Fibronectin, type III domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 359.0
HKD2_k127_6620460_7 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004261 366.0
HKD2_k127_6620460_8 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 343.0
HKD2_k127_6620460_9 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 342.0
HKD2_k127_6627570_0 Multicopper oxidase K06324 - 1.16.3.3 0.0 1665.0
HKD2_k127_6627570_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000000000004199 79.0
HKD2_k127_6627570_2 Antibiotic biosynthesis monooxygenase - - - 0.000000001101 64.0
HKD2_k127_6635859_0 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000006041 203.0
HKD2_k127_6635859_1 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000003833 185.0
HKD2_k127_6635859_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000004354 168.0
HKD2_k127_6635859_3 Histidine kinase - - - 0.000000000000000000000000000000000000000005042 177.0
HKD2_k127_6647615_0 PFAM ATP-binding region, ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 450.0
HKD2_k127_6647615_1 PFAM peptidase K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 302.0
HKD2_k127_6663999_0 peptidase M24 K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007 383.0
HKD2_k127_6720565_0 TonB dependent receptor K02014,K16092 - - 1.859e-231 735.0
HKD2_k127_6723470_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1190.0
HKD2_k127_6723470_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 556.0
HKD2_k127_6723470_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 429.0
HKD2_k127_6765622_0 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 426.0
HKD2_k127_6765622_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 341.0
HKD2_k127_6765622_2 Protein of unknown function, DUF480 K09915 - - 0.000000000000000000000000000000000000000000000000000000000000000000009885 239.0
HKD2_k127_6765622_3 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000003299 205.0
HKD2_k127_6765622_4 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000003899 48.0
HKD2_k127_6766460_0 acid phosphatase activity K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008233 335.0
HKD2_k127_6766460_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000001937 231.0
HKD2_k127_6766460_2 Domain of unknown function DUF11 - - - 0.000000000000000000000000000000000000000000000491 181.0
HKD2_k127_6766460_3 Subtilase family K13274,K14645 - - 0.00000000000000000000000000000000000000000001448 176.0
HKD2_k127_6766460_4 PFAM Fibronectin type III domain - - - 0.0000000000000000000000000000000006317 151.0
HKD2_k127_6766460_5 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000006682 60.0
HKD2_k127_6767245_0 PFAM Tripartite tricarboxylate transporter TctA family K07793 - - 0.00000000000000000000000000000000000000000000004284 171.0
HKD2_k127_6767245_1 transporter K03319 - - 0.00001318 55.0
HKD2_k127_6767245_2 Tripartite tricarboxylate transporter TctB family - - - 0.00003487 52.0
HKD2_k127_6770575_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.0 1086.0
HKD2_k127_6770575_1 Pfam:CPSase_L_chain - - - 3.373e-243 758.0
HKD2_k127_6803112_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 1.05e-222 711.0
HKD2_k127_6803112_1 ATP-independent chaperone mediated protein folding K07803 - - 0.0000000000005573 74.0
HKD2_k127_6808237_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 606.0
HKD2_k127_6876716_0 ATP-dependent helicase HrpB K03579 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 563.0
HKD2_k127_6876716_1 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007199 409.0
HKD2_k127_6876716_2 Protein tyrosine kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 370.0
HKD2_k127_6876716_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002844 279.0
HKD2_k127_6876716_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001303 241.0
HKD2_k127_6876716_5 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000001086 172.0
HKD2_k127_6876716_6 metal cluster binding K06940 - - 0.0000000000000000000000000000000000000001718 154.0
HKD2_k127_6876716_7 Protein of unknown function (DUF1059) - - - 0.000000000000000009059 89.0
HKD2_k127_6876716_8 PFAM Major Facilitator Superfamily - - - 0.00002119 49.0
HKD2_k127_6876716_9 Major Facilitator Superfamily - - - 0.0001057 53.0
HKD2_k127_6888934_0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 431.0
HKD2_k127_6888934_1 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 331.0
HKD2_k127_6888934_2 PFAM Three-deoxy-D-manno-octulosonic-acid transferase domain protein K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 306.0
HKD2_k127_6915014_0 PFAM EAL domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 574.0
HKD2_k127_6915014_1 M18 family aminopeptidase K01267 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 486.0
HKD2_k127_6915014_2 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 437.0
HKD2_k127_6915014_3 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001495 286.0
HKD2_k127_6915014_4 Pentapeptide repeats (9 copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000003829 243.0
HKD2_k127_6915014_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000001402 221.0
HKD2_k127_6915014_6 Belongs to the MurCDEF family K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000009933 189.0
HKD2_k127_6915014_7 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000008932 189.0
HKD2_k127_6915014_8 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.00000000000000000000000000000000000000000000000005351 178.0
HKD2_k127_6915014_9 - - - - 0.000000000001191 69.0
HKD2_k127_6944336_0 TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 442.0
HKD2_k127_6944336_1 PFAM Transposase IS200 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006277 316.0
HKD2_k127_6944336_2 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 310.0
HKD2_k127_6944336_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 292.0
HKD2_k127_6944336_4 Cytochrome b5-like Heme/Steroid binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001271 266.0
HKD2_k127_6944336_5 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002615 263.0
HKD2_k127_6944336_6 Cytochrome c - - - 0.0000000000000000000000005098 112.0
HKD2_k127_6944336_7 - - - - 0.00006577 52.0
HKD2_k127_696260_0 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 312.0
HKD2_k127_696260_1 PFAM peptidase U61 LD-carboxypeptidase A K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005797 282.0
HKD2_k127_696260_2 - - - - 0.00000000000000000000000001809 109.0
HKD2_k127_696260_3 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000005166 108.0
HKD2_k127_696260_4 - - - - 0.000000000000000000002393 95.0
HKD2_k127_6979064_0 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 349.0
HKD2_k127_6979064_1 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 289.0
HKD2_k127_6979064_2 Belongs to the universal stress protein A family - - - 0.00000000000000003421 87.0
HKD2_k127_6979064_3 Type II secretion system (T2SS), protein E, N-terminal domain K02243,K02652 - - 0.000000442 63.0
HKD2_k127_6979064_4 - - - - 0.0000007273 59.0
HKD2_k127_6979346_0 PFAM aminotransferase class-III K01845 - 5.4.3.8 3.632e-217 679.0
HKD2_k127_6979346_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 545.0
HKD2_k127_6979346_10 Belongs to the bacterial histone-like protein family K05788 - - 0.00000000000000000000001298 100.0
HKD2_k127_6979346_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 377.0
HKD2_k127_6979346_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 359.0
HKD2_k127_6979346_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 300.0
HKD2_k127_6979346_5 NIL - - - 0.00000000000000000000000000000000000000000000000000000000001403 210.0
HKD2_k127_6979346_6 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000000000000001042 201.0
HKD2_k127_6979346_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000005184 117.0
HKD2_k127_6979346_8 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00000000000000000000000003212 109.0
HKD2_k127_6987287_0 AcrB/AcrD/AcrF family K03296,K19594 - - 9.293e-288 892.0
HKD2_k127_6987287_1 Biotin-lipoyl like K19595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007032 484.0
HKD2_k127_7016333_0 PFAM ATP-binding region ATPase domain protein K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006403 461.0
HKD2_k127_7016333_1 - K07803 - - 0.0000000000837 68.0
HKD2_k127_7016333_2 Short C-terminal domain K08982 - - 0.00000002806 58.0
HKD2_k127_7018527_0 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000003813 226.0
HKD2_k127_7018527_1 Histidine kinase - - - 0.0000000000000000000000000000000000000152 166.0
HKD2_k127_7018527_2 PAS domain containing protein K07315,K07675 - 2.7.13.3,3.1.3.3 0.0000001594 65.0
HKD2_k127_7026695_0 PFAM Carbamoyltransferase K00612 - - 5.816e-296 917.0
HKD2_k127_7026695_1 Polysaccharide pyruvyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 582.0
HKD2_k127_7026695_2 epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006056 550.0
HKD2_k127_7026695_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 534.0
HKD2_k127_7026695_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009259 294.0
HKD2_k127_7026695_5 lysyltransferase activity K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000546 278.0
HKD2_k127_7026695_6 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000007522 233.0
HKD2_k127_7026695_7 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000000000001008 182.0
HKD2_k127_7026695_8 Hexapeptide repeat of succinyl-transferase K00633 - 2.3.1.18 0.000000000000000000000000000000009641 137.0
HKD2_k127_70455_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 1.381e-229 717.0
HKD2_k127_70455_1 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 374.0
HKD2_k127_70455_2 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000002743 249.0
HKD2_k127_70455_3 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000001569 161.0
HKD2_k127_70455_4 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000007826 117.0
HKD2_k127_70455_5 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000003113 55.0
HKD2_k127_7058359_0 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000006163 192.0
HKD2_k127_7058359_1 - - - - 0.00000000000000000000000000002825 130.0
HKD2_k127_7058359_2 protein mobile region - - - 0.000000000000000000000000002514 117.0
HKD2_k127_7058359_3 PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding K01007 - 2.7.9.2 0.000000000009057 67.0
HKD2_k127_7063930_0 RimK-like ATPgrasp N-terminal domain - - - 9.646e-202 640.0
HKD2_k127_7063930_1 Glutamate-cysteine ligase family 2(GCS2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 306.0
HKD2_k127_7063930_2 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000004512 201.0
HKD2_k127_7063930_3 Glutamate-cysteine ligase family 2(GCS2) - - - 0.0000000000000000000000000000000000007611 154.0
HKD2_k127_7088096_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 315.0
HKD2_k127_7088096_1 Protein of unknown function (DUF1566) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 311.0
HKD2_k127_7112437_0 Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 354.0
HKD2_k127_7112437_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001184 264.0
HKD2_k127_7112437_2 Pfam ATP-grasp domain K01955 - 6.3.5.5 0.0000000000000000001628 104.0
HKD2_k127_7112437_3 PFAM Receptor L domain - - - 0.000006526 59.0
HKD2_k127_7126233_0 PFAM Cys Met metabolism K01740 - 2.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 602.0
HKD2_k127_7126233_1 PFAM ABC transporter K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 378.0
HKD2_k127_7157856_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 617.0
HKD2_k127_7157856_1 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 570.0
HKD2_k127_7157856_2 Proton-conducting membrane transporter K12141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 530.0
HKD2_k127_7157856_3 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 377.0
HKD2_k127_7157856_4 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 365.0
HKD2_k127_7157856_5 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001456 282.0
HKD2_k127_7325855_0 TIGRFAM lysine 2,3-aminomutase YodO family protein K01843 - 5.4.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 615.0
HKD2_k127_7325855_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 509.0
HKD2_k127_7325855_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 462.0
HKD2_k127_7335068_0 protein conserved in bacteria - - - 3.585e-220 694.0
HKD2_k127_7348381_0 Filamentation induced by cAMP protein fic K01929,K08599 GO:0003674,GO:0003824,GO:0005575,GO:0008150,GO:0009405,GO:0016740,GO:0016772,GO:0016773,GO:0018995,GO:0030430,GO:0033643,GO:0033646,GO:0043087,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044419,GO:0044605,GO:0050790,GO:0051336,GO:0051704,GO:0065007,GO:0065009 6.3.2.10 7.812e-257 815.0
HKD2_k127_7348381_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000001374 221.0
HKD2_k127_7348381_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000009284 139.0
HKD2_k127_7386347_0 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 474.0
HKD2_k127_7386347_1 Phosphate transport regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 436.0
HKD2_k127_7386347_2 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009023 421.0
HKD2_k127_7386347_3 regulatory protein, arsR K03892 - - 0.00000000000000000000000000000000004059 137.0
HKD2_k127_7386347_4 TIGRFAM redox-active disulfide protein 2 - - - 0.000000000000000000000000000002037 121.0
HKD2_k127_7386347_5 - - - - 0.000000005667 58.0
HKD2_k127_7421649_0 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 3.209e-197 625.0
HKD2_k127_7421649_1 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012,K16180 - 2.8.1.6,5.4.99.58 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 395.0
HKD2_k127_7421649_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 302.0
HKD2_k127_7421649_3 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001411 245.0
HKD2_k127_7421649_4 AMMECR1 K09141 - - 0.000000000000000000000000000000000000000000000000000000000002358 214.0
HKD2_k127_7459996_0 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006299 258.0
HKD2_k127_7459996_1 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000001245 219.0
HKD2_k127_7497997_0 histidine kinase HAMP region domain protein K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 377.0
HKD2_k127_7608588_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 5.6e-199 629.0
HKD2_k127_7608588_1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase K01802,K03772,K03773 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000001072 250.0
HKD2_k127_7608588_2 Pyridine nucleotide-disulphide oxidoreductase K22405 - 1.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000005012 252.0
HKD2_k127_7608588_3 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 0.0000000000000000000000000000000000000000000000000000000001508 205.0
HKD2_k127_7608588_4 PFAM 4Fe-4S K00196 - - 0.0000000000000000000000000000000000000000000001687 173.0
HKD2_k127_7608588_5 OSK domain - - - 0.00000000000000000000000000000000005842 143.0
HKD2_k127_7608588_6 - - - - 0.000000000000000000000000000000000137 137.0
HKD2_k127_7655971_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1389.0
HKD2_k127_7655971_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 3.227e-282 882.0
HKD2_k127_7655971_12 coenzyme F420 binding K00275 - 1.4.3.5 0.000000000001839 70.0
HKD2_k127_7655971_2 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 456.0
HKD2_k127_7655971_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 430.0
HKD2_k127_7655971_4 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 414.0
HKD2_k127_7655971_5 Trm112p-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005061 355.0
HKD2_k127_7655971_6 Mechanosensitive ion channel K05802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000847 373.0
HKD2_k127_7655971_7 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 294.0
HKD2_k127_7655971_8 Lipocalin-like domain K03098 - - 0.0000000000000000000000000000000000000000000000000000003993 200.0
HKD2_k127_7655971_9 PFAM pyridoxamine 5-phosphate - - - 0.000000000000000000000000000000000000000000001672 168.0
HKD2_k127_7659379_0 FecR protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 361.0
HKD2_k127_7659379_1 CHASE2 K01768 - 4.6.1.1 0.00000000000000000000000000000000000000007884 158.0
HKD2_k127_7659379_2 FecR protein - - - 0.000007018 51.0
HKD2_k127_7693280_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 383.0
HKD2_k127_7693280_1 Thioredoxin domain - - - 0.000000000000000000000000000000000000000000001005 171.0
HKD2_k127_7693280_2 metal-dependent phosphohydrolase HD sub K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000345 170.0
HKD2_k127_7693280_3 Protein of unknown function (DUF4019) - - - 0.00000000000000000000000000000000000615 142.0
HKD2_k127_7739625_0 ABC transporter transmembrane region K06147,K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 586.0
HKD2_k127_7739625_1 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005521 278.0
HKD2_k127_7739625_2 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000009793 203.0
HKD2_k127_7739625_3 ABC transporter transmembrane region K06147,K18890 - - 0.000000000000000000000000000000000000000000000000000002416 200.0
HKD2_k127_7739625_4 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000003184 181.0
HKD2_k127_7780937_0 Domain of unknown function (DUF4113) K02346,K03502 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 445.0
HKD2_k127_7780937_1 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 420.0
HKD2_k127_7780937_10 Histidine kinase - - - 0.000000000000000000007791 104.0
HKD2_k127_7780937_11 Histidine kinase K02660,K11525 - - 0.0000000008486 70.0
HKD2_k127_7780937_12 heat shock protein binding - - - 0.00000003825 67.0
HKD2_k127_7780937_13 Subtilase family - - - 0.0000009842 59.0
HKD2_k127_7780937_3 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 288.0
HKD2_k127_7780937_4 histidine kinase HAMP region domain protein K03406 - - 0.000000000000000000000000000000000000000000000000000000000000003446 243.0
HKD2_k127_7780937_5 Belongs to the peptidase S24 family K03503 - - 0.00000000000000000000000000000000000000000000000000000004088 199.0
HKD2_k127_7780937_6 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000004964 184.0
HKD2_k127_7780937_7 Uncharacterised protein family UPF0066 - - - 0.0000000000000000000000000000000000000001975 153.0
HKD2_k127_7780937_8 transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.00000000000000000000000006723 109.0
HKD2_k127_7780937_9 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000198 100.0
HKD2_k127_778223_0 Psort location Cytoplasmic, score 9.97 K00656 - 2.3.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 310.0
HKD2_k127_778223_1 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000001868 228.0
HKD2_k127_7786310_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1230.0
HKD2_k127_7786310_1 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 2.823e-288 902.0
HKD2_k127_7786310_10 Glucose-1-phosphate adenylyltransferase K00975 - 2.7.7.27 0.0000000000000018 76.0
HKD2_k127_7786310_2 response regulator receiver K13599 - - 1.852e-200 632.0
HKD2_k127_7786310_3 Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family K00975,K20427 - 2.7.7.27,2.7.7.91 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 602.0
HKD2_k127_7786310_4 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 565.0
HKD2_k127_7786310_5 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 345.0
HKD2_k127_7786310_6 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000000000000000000000000000001691 196.0
HKD2_k127_7786310_7 - K07039 - - 0.000000000000000000000000000000000000000000000000001122 187.0
HKD2_k127_7786310_8 VanZ like family - - - 0.0000000000000000000006174 106.0
HKD2_k127_7786310_9 Competence protein K02237 - - 0.000000000000000003056 86.0
HKD2_k127_7790974_0 response regulator receiver K02481 - - 1.325e-239 746.0
HKD2_k127_7790974_1 ATPase associated with various cellular activities AAA_5 K04748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 420.0
HKD2_k127_7790974_2 Von Willebrand factor type A K02448 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 356.0
HKD2_k127_7790974_3 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 295.0
HKD2_k127_7792416_0 Cysteine rich repeat - - - 0.0000000000000000000000000000000000000000000000000005518 187.0
HKD2_k127_7792416_1 long-chain fatty acid transport protein - - - 0.000000000000000000000000000000000000000000000007557 182.0
HKD2_k127_7792416_2 - - - - 0.000000000000000000000000000000000000000001667 173.0
HKD2_k127_7807799_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 1e-323 1011.0
HKD2_k127_7807799_1 (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006123 295.0
HKD2_k127_7807799_2 AAA domain K07028 - - 0.0000000000000000000000000000003694 126.0
HKD2_k127_7808929_0 Pyruvate phosphate dikinase, PEP K01006 - 2.7.9.1 0.0 1940.0
HKD2_k127_7847629_0 4Fe-4S dicluster domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008527 544.0
HKD2_k127_7847629_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 378.0
HKD2_k127_7847629_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002494 233.0
HKD2_k127_7853058_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1723.0
HKD2_k127_7853058_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1450.0
HKD2_k127_7853058_2 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005173 580.0
HKD2_k127_7853058_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 500.0
HKD2_k127_7853058_4 MarR family - - - 0.000000000000004282 81.0
HKD2_k127_7874231_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005502 471.0
HKD2_k127_7874231_1 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 372.0
HKD2_k127_7874231_2 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000000003421 227.0
HKD2_k127_7874231_3 PFAM transcriptional regulator PadR family protein - - - 0.0000000000000000000000000000000000002249 146.0
HKD2_k127_7881728_0 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 444.0
HKD2_k127_7881728_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009377 353.0
HKD2_k127_7881728_2 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 310.0
HKD2_k127_7881728_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000259 273.0
HKD2_k127_7881728_4 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000353 191.0
HKD2_k127_7888376_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 401.0
HKD2_k127_7888376_1 Desulfoferrodoxin K05919 - 1.15.1.2 0.000000000000000000000000000000000000000000000000000002704 194.0
HKD2_k127_7888376_2 Rubrerythrin - - - 0.00000000000000000000000000000000000000000005649 165.0
HKD2_k127_7888376_3 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000003355 159.0
HKD2_k127_7888376_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000004884 153.0
HKD2_k127_7888376_5 - - - - 0.000000000000000000000000000000005319 131.0
HKD2_k127_7888376_6 Universal stress protein family - - - 0.0000000000000000002845 97.0
HKD2_k127_7896120_0 Chemotaxis sensory transducer - - - 0.0000000000000000000000000000000000000002364 170.0
HKD2_k127_7896120_1 STAS domain - - - 0.000000002311 61.0
HKD2_k127_7905750_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 484.0
HKD2_k127_7905750_1 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000000001129 156.0
HKD2_k127_7921973_0 Protein of unknown function, DUF255 K06888 - - 1.089e-211 680.0
HKD2_k127_7921973_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 1.739e-197 623.0
HKD2_k127_7921973_10 - - - - 0.0000000000000002951 88.0
HKD2_k127_7921973_11 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.000000000000003305 82.0
HKD2_k127_7921973_12 PFAM Cold-shock protein, DNA-binding - - - 0.00000000000284 74.0
HKD2_k127_7921973_13 Diguanylate cyclase - - - 0.0000005719 61.0
HKD2_k127_7921973_14 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0001078 46.0
HKD2_k127_7921973_2 Alcohol dehydrogenase GroES-like domain K13979 - - 1.588e-196 617.0
HKD2_k127_7921973_3 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 556.0
HKD2_k127_7921973_4 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 341.0
HKD2_k127_7921973_5 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001111 260.0
HKD2_k127_7921973_6 SMART Metal-dependent phosphohydrolase, HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000231 269.0
HKD2_k127_7921973_7 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001725 249.0
HKD2_k127_7921973_8 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000003493 118.0
HKD2_k127_7921973_9 PFAM ATP-binding region ATPase domain protein K07678 - 2.7.13.3 0.0000000000000000007394 97.0
HKD2_k127_7953001_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1130.0
HKD2_k127_7953001_1 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 2.512e-289 900.0
HKD2_k127_7953001_10 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 352.0
HKD2_k127_7953001_11 Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 307.0
HKD2_k127_7953001_12 PBP superfamily domain K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 291.0
HKD2_k127_7953001_13 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 291.0
HKD2_k127_7953001_14 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001933 273.0
HKD2_k127_7953001_16 'Cold-shock' DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002429 242.0
HKD2_k127_7953001_18 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000002756 173.0
HKD2_k127_7953001_19 helix_turn_helix, Arsenical Resistance Operon Repressor K22043 - - 0.000000000000000000000000000004133 124.0
HKD2_k127_7953001_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 8.466e-221 690.0
HKD2_k127_7953001_20 manually curated K06039 - - 0.000000000000000000000003261 103.0
HKD2_k127_7953001_21 - - - - 0.00000000000000000000001449 102.0
HKD2_k127_7953001_22 PFAM Type IV pilus assembly PilZ - - - 0.00000000000000334 81.0
HKD2_k127_7953001_23 - - - - 0.0000000000003344 72.0
HKD2_k127_7953001_24 manually curated K06039 - - 0.0000000001301 61.0
HKD2_k127_7953001_3 amine dehydrogenase activity - - - 5.368e-220 716.0
HKD2_k127_7953001_4 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 1.723e-198 621.0
HKD2_k127_7953001_5 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 534.0
HKD2_k127_7953001_6 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 529.0
HKD2_k127_7953001_7 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007743 439.0
HKD2_k127_7953001_8 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 387.0
HKD2_k127_7953001_9 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 339.0
HKD2_k127_7984126_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 615.0
HKD2_k127_7984126_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008291 487.0
HKD2_k127_7984126_2 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000128 209.0
HKD2_k127_7984126_3 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000001297 131.0
HKD2_k127_801415_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1114.0
HKD2_k127_801415_1 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 4.604e-295 915.0
HKD2_k127_801415_10 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000483 202.0
HKD2_k127_801415_11 TIGRFAM Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000649 179.0
HKD2_k127_801415_12 CGGC - - - 0.0000000000000000000000000000000000000897 151.0
HKD2_k127_801415_13 Spermine/spermidine synthase domain - - - 0.00000000000000000000000000000000000165 148.0
HKD2_k127_801415_15 - - - - 0.0000000000000002121 80.0
HKD2_k127_801415_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 596.0
HKD2_k127_801415_3 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 565.0
HKD2_k127_801415_4 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 451.0
HKD2_k127_801415_5 Di-haem cytochrome c peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 346.0
HKD2_k127_801415_6 GGDEF domain K13069 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 334.0
HKD2_k127_801415_7 HlyD family secretion protein K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 314.0
HKD2_k127_801415_8 PFAM peptidase M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002192 272.0
HKD2_k127_801415_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002638 261.0
HKD2_k127_803607_0 TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD K16013 - - 1.995e-198 634.0
HKD2_k127_803607_1 PFAM Cytochrome bd ubiquinol oxidase, subunit I K00425 - 1.10.3.14 0.0000000000000000000000007173 104.0
HKD2_k127_803607_2 TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC K16012 - - 0.00000223 53.0
HKD2_k127_8066854_0 PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis K02585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009057 323.0
HKD2_k127_8066854_1 This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation K02591 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000001497 213.0
HKD2_k127_8066854_2 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000001462 183.0
HKD2_k127_8066854_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000319 167.0
HKD2_k127_8066854_4 - - - - 0.000000000000000000000000002829 113.0
HKD2_k127_8066854_5 - - - - 0.00000000000000000000002415 105.0
HKD2_k127_8081097_0 AAA domain (Cdc48 subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006535 501.0
HKD2_k127_8081097_1 VWA containing CoxE family protein K09989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008933 239.0
HKD2_k127_8083893_0 CHAD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001542 275.0
HKD2_k127_8103156_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0 1031.0
HKD2_k127_8103156_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 4.616e-221 694.0
HKD2_k127_8103156_10 SMART Metal-dependent phosphohydrolase, HD region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 304.0
HKD2_k127_8103156_11 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009794 275.0
HKD2_k127_8103156_12 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000000000000000000000000000002448 236.0
HKD2_k127_8103156_13 MlaD protein K06192 - - 0.0000000000000000000000000000000000000000000000000000000002764 219.0
HKD2_k127_8103156_14 Uncharacterised protein family (UPF0153) K06940 - - 0.000000000000000000000000000000009808 134.0
HKD2_k127_8103156_15 ABC-type transport auxiliary lipoprotein component K09857 - - 0.00000000000000000000000000000001013 136.0
HKD2_k127_8103156_16 chain release factor K15034 - - 0.000000000000000000000000000001837 126.0
HKD2_k127_8103156_17 RNA-binding protein - - - 0.00000000000000000000000000001629 119.0
HKD2_k127_8103156_18 cytochrome C peroxidase - - - 0.00000000000000000001344 94.0
HKD2_k127_8103156_19 iron ion homeostasis K04758 - - 0.0000000000000000004237 91.0
HKD2_k127_8103156_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 9.224e-202 663.0
HKD2_k127_8103156_21 galactose-1-phosphate uridylyltransferase - - - 0.000000803 51.0
HKD2_k127_8103156_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 512.0
HKD2_k127_8103156_4 DEAD DEAH box helicase K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 509.0
HKD2_k127_8103156_5 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 511.0
HKD2_k127_8103156_6 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 388.0
HKD2_k127_8103156_7 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 359.0
HKD2_k127_8103156_8 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 345.0
HKD2_k127_8103156_9 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008697 344.0
HKD2_k127_8128646_0 PFAM Acyltransferase - - - 3.467e-226 716.0
HKD2_k127_8128646_1 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006401 522.0
HKD2_k127_8128646_2 metallopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 491.0
HKD2_k127_8128646_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009402 258.0
HKD2_k127_8128646_4 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000002273 207.0
HKD2_k127_816566_0 SMART Metal-dependent phosphohydrolase, HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 336.0
HKD2_k127_816566_1 lyase activity - - - 0.0000000000000000000000000000000000001141 161.0
HKD2_k127_816566_2 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000269 157.0
HKD2_k127_816566_3 Sulfotransferase domain K13472 - - 0.000000000000000000000000000009927 130.0
HKD2_k127_816566_4 Pterin binding enzyme K15023 - 2.1.1.258 0.0000001625 61.0
HKD2_k127_8175580_0 pfam abc-1 K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 326.0
HKD2_k127_8175580_1 L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 311.0
HKD2_k127_8175580_2 Flavodoxin domain - - - 0.0000000000000000000000000000000000000000000000000002925 192.0
HKD2_k127_8175580_3 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000007625 139.0
HKD2_k127_8175580_4 Putative transmembrane protein (PGPGW) - - - 0.0000000000000000000000002152 114.0
HKD2_k127_8175580_5 granule-associated protein - - - 0.000000000000000000005536 96.0
HKD2_k127_8175580_6 Domain of Unknown Function (DUF748) - - - 0.0001963 53.0
HKD2_k127_8177168_0 radical SAM K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 423.0
HKD2_k127_8177168_1 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000000000000000000000000000008496 170.0
HKD2_k127_8177168_2 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.000000005532 59.0
HKD2_k127_8220983_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006902 601.0
HKD2_k127_8220983_1 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007458 345.0
HKD2_k127_8220983_2 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001501 273.0
HKD2_k127_8220983_3 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K01091 - 3.1.3.18 0.0000000000000000000000000000000000008292 141.0
HKD2_k127_8227114_0 PFAM oxidoreductase FAD NAD(P)-binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 367.0
HKD2_k127_8227114_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K16950 - - 0.000000000000000000000000000000000000000000000000000000000000000000005563 241.0
HKD2_k127_8307074_0 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 488.0
HKD2_k127_8307074_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 412.0
HKD2_k127_8348190_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007579 497.0
HKD2_k127_8348190_1 Sodium Bile acid symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 406.0
HKD2_k127_8348190_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 388.0
HKD2_k127_8348190_3 ATP-binding region, ATPase domain protein domain protein K07677,K20974 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 331.0
HKD2_k127_8348190_6 response regulator - - - 0.000000000000000007098 97.0
HKD2_k127_8348190_7 2 iron, 2 sulfur cluster binding K00303 - 1.5.3.1 0.0000000000000000383 85.0
HKD2_k127_8348190_8 ankyrin repeat-containing protein - - - 0.0002086 51.0
HKD2_k127_8420573_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 2.938e-252 785.0
HKD2_k127_8420573_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 536.0
HKD2_k127_8420573_2 TIGRFAM deoxyguanosinetriphosphate triphosphohydrolase K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007716 509.0
HKD2_k127_8420573_3 4Fe-4S dicluster domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000384 278.0
HKD2_k127_8420573_4 - - - - 0.000000132 62.0
HKD2_k127_842409_0 regulation of DNA-templated transcription, elongation - - - 4.295e-294 924.0
HKD2_k127_842409_1 sulphate transporter - - - 4.344e-221 700.0
HKD2_k127_842409_2 Glycogen debranching enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006591 518.0
HKD2_k127_842409_3 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 450.0
HKD2_k127_842409_4 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 368.0
HKD2_k127_842409_5 Protein of unknown function (DUF2950) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 334.0
HKD2_k127_842409_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001126 259.0
HKD2_k127_842409_7 Protein of unknown function (DUF3313) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001039 238.0
HKD2_k127_842409_8 Ion channel - - - 0.0000000000000000000000000000000000004912 149.0
HKD2_k127_8432506_0 Histidine kinase K07646 - 2.7.13.3 0.0 1219.0
HKD2_k127_8432506_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1085.0
HKD2_k127_8432506_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 9.241e-289 897.0
HKD2_k127_8432506_3 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008865 365.0
HKD2_k127_8432506_4 Two component transcriptional regulator, winged helix family K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 327.0
HKD2_k127_8432506_5 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000004851 250.0
HKD2_k127_8432506_6 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000001273 233.0
HKD2_k127_8432506_7 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000000002964 105.0
HKD2_k127_8456207_0 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001504 274.0
HKD2_k127_8456207_1 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000008126 227.0
HKD2_k127_8462181_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 2.787e-242 769.0
HKD2_k127_8462181_1 PFAM Nitrate reductase gamma subunit K00374 - 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005894 446.0
HKD2_k127_8462181_2 RsbT co-antagonist protein rsbRD N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000006454 209.0
HKD2_k127_8471291_0 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006752 449.0
HKD2_k127_8471291_1 - - - - 0.0000000000000000000000000001155 123.0
HKD2_k127_8471291_2 domain protein K06894 - - 0.00002824 58.0
HKD2_k127_8471291_3 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.0001562 54.0
HKD2_k127_8475807_0 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 357.0
HKD2_k127_8475807_1 Protein of unknown function (DUF1566) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001665 248.0
HKD2_k127_8475807_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000005933 215.0
HKD2_k127_8475807_3 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.0000000000000000000000000000000000000000002787 170.0
HKD2_k127_8475807_4 methyltransferase type - - - 0.0000000000000000000000000000458 126.0
HKD2_k127_8475807_5 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000006548 103.0
HKD2_k127_8475807_6 Protein of unknown function (DUF1566) - - - 0.000000000000000003495 89.0
HKD2_k127_8475807_7 domain, Protein - - - 0.000000000000002711 80.0
HKD2_k127_8475807_8 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000001422 80.0
HKD2_k127_8478642_0 DNA replication proofreading K02336,K06877 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007346 424.0
HKD2_k127_8478642_1 SMART Tetratricopeptide domain protein - - - 0.00000000000000000000000000000000000002225 162.0
HKD2_k127_8478642_2 - - - - 0.000000001467 65.0
HKD2_k127_8583639_0 Chromate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 456.0
HKD2_k127_8583639_1 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 308.0
HKD2_k127_8583639_2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000001644 262.0
HKD2_k127_8583639_3 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000000000000000000000005282 231.0
HKD2_k127_8583639_4 SMART metal-dependent phosphohydrolase, HD region K06950 - - 0.000000000001703 69.0
HKD2_k127_8654233_0 4-hydroxybenzoate polyprenyltransferase K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 412.0
HKD2_k127_8654233_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 327.0
HKD2_k127_8654233_2 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 291.0
HKD2_k127_8654233_3 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000000000000000000006265 235.0
HKD2_k127_8654233_4 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000000000000000000000000000003762 180.0
HKD2_k127_8654233_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000007351 154.0
HKD2_k127_8654233_6 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.000000000000008248 75.0
HKD2_k127_8688000_0 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K15792 - 6.3.2.10,6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 514.0
HKD2_k127_8688000_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 326.0
HKD2_k127_8688000_2 penicillin binding K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 311.0
HKD2_k127_8688000_3 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.0000000000000000000000000000000000000000009789 161.0
HKD2_k127_875163_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005803 548.0
HKD2_k127_875163_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 490.0
HKD2_k127_875163_10 Protein of Unknown function (DUF2784) - - - 0.0000000000000000000000000000002862 128.0
HKD2_k127_875163_11 5'-nucleotidase, C-terminal domain - - - 0.000000000000001092 81.0
HKD2_k127_875163_2 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004802 481.0
HKD2_k127_875163_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007521 436.0
HKD2_k127_875163_4 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006327 394.0
HKD2_k127_875163_5 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006218 362.0
HKD2_k127_875163_6 Nitrite/Sulfite reductase ferredoxin-like half domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 312.0
HKD2_k127_875163_7 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000005793 189.0
HKD2_k127_875163_8 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000001991 155.0
HKD2_k127_875163_9 DoxX - - - 0.0000000000000000000000000000000003945 137.0
HKD2_k127_8753425_0 glycyl-tRNA synthetase, beta K01879 - 6.1.1.14 2.269e-250 790.0
HKD2_k127_8753425_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004422 570.0
HKD2_k127_8753425_2 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008975 285.0
HKD2_k127_8753425_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000005117 192.0
HKD2_k127_8753425_4 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000000000000000000000000000001683 179.0
HKD2_k127_8753425_5 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000005576 177.0
HKD2_k127_8753425_6 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000005317 70.0
HKD2_k127_8771804_0 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002218 255.0
HKD2_k127_8771804_1 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000003337 202.0
HKD2_k127_8787646_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1069.0
HKD2_k127_8787646_1 Belongs to the peptidase M16 family K07263 - - 4.465e-280 890.0
HKD2_k127_8787646_10 phosphate ion binding K02040 - - 0.0000000000000000000000000000000000000000000000000000007628 202.0
HKD2_k127_8787646_11 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.0000000000000000000000000000000000000003421 150.0
HKD2_k127_8787646_12 PFAM ResB family protein K07399 - - 0.0000000000000000000000000000000000001374 145.0
HKD2_k127_8787646_13 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000000000009808 116.0
HKD2_k127_8787646_14 Domain of unknown function (DUF4156) - - - 0.000000000000000000000002495 105.0
HKD2_k127_8787646_15 Protein of unknown function (DUF2892) - - - 0.00000000000000000000007746 100.0
HKD2_k127_8787646_17 Protein of unknown function (DUF2905) - - - 0.00000000000000000000147 98.0
HKD2_k127_8787646_18 sequence-specific DNA binding - - - 0.000002322 53.0
HKD2_k127_8787646_19 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00003002 48.0
HKD2_k127_8787646_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 1.505e-222 701.0
HKD2_k127_8787646_3 Alanine dehydrogenase/PNT, C-terminal domain K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008662 580.0
HKD2_k127_8787646_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 482.0
HKD2_k127_8787646_5 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 375.0
HKD2_k127_8787646_6 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 357.0
HKD2_k127_8787646_7 PFAM short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 300.0
HKD2_k127_8787646_8 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009745 246.0
HKD2_k127_8787646_9 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00366,K05934,K21479 - 1.7.7.1,2.1.1.131,2.1.1.272 0.0000000000000000000000000000000000000000000000000000000001444 211.0
HKD2_k127_8807540_0 CDP-archaeol synthase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007466 510.0
HKD2_k127_8807540_1 pfam abc-1 K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 425.0
HKD2_k127_8817345_0 Heat shock 70 kDa protein K04043 - - 2.5e-323 994.0
HKD2_k127_8817345_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.471e-259 812.0
HKD2_k127_8817345_10 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000003727 102.0
HKD2_k127_8817345_11 Bacterial antitoxin of type II TA system, VapB - - - 0.00000000000000000001477 92.0
HKD2_k127_8817345_2 Aminotransferase class I and II K00814 - 2.6.1.2 2.808e-233 727.0
HKD2_k127_8817345_3 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 579.0
HKD2_k127_8817345_4 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 505.0
HKD2_k127_8817345_5 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 374.0
HKD2_k127_8817345_6 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 331.0
HKD2_k127_8817345_7 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001046 283.0
HKD2_k127_8817345_8 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000399 213.0
HKD2_k127_8817345_9 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000000000001528 170.0
HKD2_k127_8842153_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.104e-293 912.0
HKD2_k127_8856326_0 UvrD REP helicase K03657 - 3.6.4.12 1.874e-300 939.0
HKD2_k127_8856326_1 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 462.0
HKD2_k127_8856326_10 membrane - - - 0.000000000000000000000000000000000000000000000000000000005839 204.0
HKD2_k127_8856326_11 Protein of unknown function (DUF401) K09133 - - 0.0000000000000000000000000000000000000000000000000000003739 210.0
HKD2_k127_8856326_12 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000001714 175.0
HKD2_k127_8856326_13 Membrane - - - 0.000000000000000000000000000000000000000000000007243 182.0
HKD2_k127_8856326_14 Chromosome partitioning protein ParA K03496 - - 0.00000000000000000000000000000000000000000000001022 183.0
HKD2_k127_8856326_15 PFAM HNH endonuclease K07451 - - 0.000000000000000000000000000000000000000000006974 167.0
HKD2_k127_8856326_16 - - - - 0.0000000000000000000000000000000000000000001161 162.0
HKD2_k127_8856326_18 Domain of unknown function (DUF4388) K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000001009 150.0
HKD2_k127_8856326_19 PFAM Smr protein MutS2 - - - 0.0000000000000000000000000000003823 126.0
HKD2_k127_8856326_2 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 443.0
HKD2_k127_8856326_20 phosphorelay signal transduction system K13599 - - 0.0000000000000000000005896 105.0
HKD2_k127_8856326_21 Sel1 domain protein repeat-containing protein K07126 - - 0.00000000000000008491 85.0
HKD2_k127_8856326_22 SMART chemotaxis sensory transducer K03406 - - 0.0000000000000001702 94.0
HKD2_k127_8856326_23 Protein of unknown function (DUF493) K09158 - - 0.00000000000001773 77.0
HKD2_k127_8856326_3 PFAM oxidoreductase domain protein K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 438.0
HKD2_k127_8856326_4 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005927 430.0
HKD2_k127_8856326_5 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 427.0
HKD2_k127_8856326_6 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 341.0
HKD2_k127_8856326_7 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 335.0
HKD2_k127_8856326_8 UPF0056 membrane protein K05595 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009553 297.0
HKD2_k127_8856326_9 Histidine Phosphotransfer domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000003939 272.0
HKD2_k127_8861295_0 Neisseria PilC beta-propeller domain - - - 4.529e-272 912.0
HKD2_k127_8861295_1 Sigma-54 interaction domain K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 530.0
HKD2_k127_8861295_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 318.0
HKD2_k127_8861295_3 pilus assembly protein PilW - - - 0.00000000000000000000000000000000000000000007555 171.0
HKD2_k127_8861295_4 PilX N-terminal - - - 0.000000000000000000000000003971 120.0
HKD2_k127_8861295_5 type IV pilus modification protein PilV K02671 - - 0.000000000000000001161 93.0
HKD2_k127_8861295_6 Prokaryotic N-terminal methylation motif K08084 - - 0.0000000000001225 79.0
HKD2_k127_8866782_0 PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 419.0
HKD2_k127_8866782_1 PEP-utilising enzyme, mobile domain - - - 0.000000000000000000000000000000000000000000000000000008768 203.0
HKD2_k127_8888341_0 Belongs to the 'phage' integrase family K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 380.0
HKD2_k127_8888341_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075,K15780 - 2.4.2.8,6.3.4.19 0.000000000000000000000000000003011 127.0
HKD2_k127_8890752_0 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000084 462.0
HKD2_k127_8890752_1 PFAM Tetratricopeptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000554 270.0
HKD2_k127_8890752_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001378 255.0
HKD2_k127_8890752_3 lyase activity - - - 0.000000000000000000000000000000000000000000000007444 175.0
HKD2_k127_8890752_4 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000000000000000000005427 98.0
HKD2_k127_8946475_0 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007795 313.0
HKD2_k127_8946475_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002722 271.0
HKD2_k127_8946475_2 cyclic nucleotide-binding K10914 - - 0.00000000000000000000000000000000000000000000000000000000005206 218.0
HKD2_k127_8946475_3 self proteolysis - - - 0.000000000000000001912 99.0
HKD2_k127_8958679_0 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002225 282.0
HKD2_k127_8958679_1 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000007893 186.0
HKD2_k127_8959060_0 Belongs to the LarC family K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002845 418.0
HKD2_k127_8959060_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 397.0
HKD2_k127_8959060_2 metal cluster binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 295.0
HKD2_k127_8959060_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000001068 247.0
HKD2_k127_8959060_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000003183 241.0
HKD2_k127_8959060_5 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000000000000000000000000000000000000000000000003246 196.0
HKD2_k127_8959060_6 - - - - 0.00000000000000000000000000001876 130.0
HKD2_k127_8959060_7 Heat shock protein DnaJ domain protein K06203,K07126 - - 0.0000000000000000000000000002148 124.0
HKD2_k127_8975209_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 599.0
HKD2_k127_8975209_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 595.0
HKD2_k127_8975209_10 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000001587 219.0
HKD2_k127_8975209_11 - - - - 0.0000000000000000000000000000000000000000000000002539 179.0
HKD2_k127_8975209_12 Protein of unknown function (DUF452) K09789 - 3.1.1.85 0.000000000000000000000000000000000000000000005176 175.0
HKD2_k127_8975209_13 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.0000000000000000000000000000000001416 139.0
HKD2_k127_8975209_14 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.000000000000000000000000000000365 132.0
HKD2_k127_8975209_15 Belongs to the ArsC family - - - 0.0000000000000000000000001206 108.0
HKD2_k127_8975209_16 Serine Threonine protein kinase - - - 0.0000000000000000000004594 113.0
HKD2_k127_8975209_17 - - - - 0.0000000000000000168 89.0
HKD2_k127_8975209_18 Bacterial periplasmic substrate-binding proteins K02030 - - 0.00000000000000001797 85.0
HKD2_k127_8975209_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 563.0
HKD2_k127_8975209_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 565.0
HKD2_k127_8975209_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 469.0
HKD2_k127_8975209_5 Aminotransferase class I and II K00652 - 2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004547 426.0
HKD2_k127_8975209_6 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 323.0
HKD2_k127_8975209_7 membrane K08984 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 303.0
HKD2_k127_8975209_8 PFAM Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001906 288.0
HKD2_k127_8975209_9 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000007781 233.0
HKD2_k127_898288_0 Participates in both transcription termination and antitermination K02600 - - 1.068e-207 653.0
HKD2_k127_898288_1 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 332.0
HKD2_k127_898288_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 303.0
HKD2_k127_898288_3 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000000000000000000000005151 185.0
HKD2_k127_898288_4 Nucleic-acid-binding protein implicated in transcription termination K02600,K07742 - - 0.0000003161 54.0
HKD2_k127_9018600_0 ABC-type polysaccharide polyol phosphate transport system, ATPase component K01990,K09691,K09693 - 3.6.3.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 351.0
HKD2_k127_9018600_1 glycosyl transferase family 2 K20444 - - 0.00000004626 58.0
HKD2_k127_9030918_0 isocitrate dehydrogenase, NADP-dependent, monomeric type K00031 - 1.1.1.42 0.0 1106.0
HKD2_k127_9030918_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 547.0
HKD2_k127_9030918_2 surface antigen variable number repeat protein K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 542.0
HKD2_k127_9030918_3 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 521.0
HKD2_k127_9030918_4 PFAM Phosphoribosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000006783 232.0
HKD2_k127_9040491_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 3.064e-296 912.0
HKD2_k127_9040491_1 AMP-binding enzyme K22319 - 6.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004972 617.0
HKD2_k127_9040491_2 PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III K22317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008622 518.0
HKD2_k127_9040491_3 3-beta hydroxysteroid dehydrogenase isomerase K21271,K22320 - 1.1.1.394,1.1.1.412 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 366.0
HKD2_k127_9040491_4 alpha/beta hydrolase fold K01563,K22318 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 322.0
HKD2_k127_9040491_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005259 270.0
HKD2_k127_9040491_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000002308 206.0
HKD2_k127_9040491_7 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000001141 151.0
HKD2_k127_9058963_0 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005911 357.0
HKD2_k127_9058963_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 302.0
HKD2_k127_9058963_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 289.0
HKD2_k127_9058963_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009904 250.0
HKD2_k127_9058963_4 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002108 233.0
HKD2_k127_9058963_5 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004338 231.0
HKD2_k127_9058963_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000005029 113.0
HKD2_k127_9058963_7 - - - - 0.000000000000001183 81.0
HKD2_k127_9062471_0 Carbamoyl-phosphate synthetase large chain oligomerisation K01955 - 6.3.5.5 0.0 1778.0
HKD2_k127_9062471_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 5.604e-319 986.0
HKD2_k127_9062471_2 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003982 276.0
HKD2_k127_9062471_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000001052 84.0
HKD2_k127_9110116_0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase K19200 - - 0.000000000000000000000000000000000000000000000000000000000000000004058 236.0
HKD2_k127_9110116_1 Domain of unknown function (DUF296) K06934 - - 0.00000004913 61.0
HKD2_k127_9124675_0 Elongation factor Tu domain 2 K06207 - - 0.0 1022.0
HKD2_k127_9124675_1 Bacterial regulatory protein, Fis family - - - 6.741e-205 664.0
HKD2_k127_9124675_12 GAF domain - - - 0.0000004135 61.0
HKD2_k127_9124675_2 type III restriction protein res subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 549.0
HKD2_k127_9124675_3 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 349.0
HKD2_k127_9124675_4 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000001892 201.0
HKD2_k127_9124675_5 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000004846 203.0
HKD2_k127_9124675_7 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.000000000000000000000000000000000000000000000000003277 183.0
HKD2_k127_9124675_8 Domain of unknown function (DUF309) - - - 0.000000000000000000000000000000000000000411 156.0
HKD2_k127_9124675_9 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000003294 156.0
HKD2_k127_9140910_0 phosphate acetyltransferase K00625,K13788 - 2.3.1.8 3.593e-230 724.0
HKD2_k127_9140910_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 501.0
HKD2_k127_9140910_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000001334 143.0
HKD2_k127_9155519_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 507.0
HKD2_k127_9155519_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000004734 250.0
HKD2_k127_9155519_2 PFAM Maf family protein K06287 - - 0.0000000000000000000000000000000000000000000000007628 181.0
HKD2_k127_9155519_3 cyclic nucleotide-binding K10914 - - 0.000000000000000000000009651 112.0
HKD2_k127_9197570_0 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 546.0
HKD2_k127_9197570_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001282 286.0
HKD2_k127_9197570_2 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000002664 256.0
HKD2_k127_9197570_3 PFAM CYTH domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000003502 199.0
HKD2_k127_9209251_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.0 1065.0
HKD2_k127_9209251_1 response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 567.0
HKD2_k127_9209251_10 Ribosomal protein L35 K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000002884 92.0
HKD2_k127_9209251_11 Belongs to the ABC transporter superfamily K13896 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000002886 75.0
HKD2_k127_9209251_12 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.00001569 47.0
HKD2_k127_9209251_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 576.0
HKD2_k127_9209251_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 485.0
HKD2_k127_9209251_4 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 452.0
HKD2_k127_9209251_5 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007413 282.0
HKD2_k127_9209251_6 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002178 273.0
HKD2_k127_9209251_7 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000000000000004495 183.0
HKD2_k127_9209251_8 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000000008845 183.0
HKD2_k127_9209251_9 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000001967 123.0
HKD2_k127_9230632_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 1.358e-205 651.0
HKD2_k127_9230632_1 Methylene-tetrahydrofolate reductase C terminal K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 527.0
HKD2_k127_9230632_2 PFAM aminoglycoside phosphotransferase K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000142 285.0
HKD2_k127_9230632_3 - - - - 0.00000000000000000000000000000000000000000000000000000001974 199.0
HKD2_k127_9230632_4 Prokaryotic diacylglycerol kinase - - - 0.000000000000000000000000000000000000003653 150.0
HKD2_k127_9230632_5 Acid phosphatase homologues K01096,K19302 - 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.00000000000000000000000001189 117.0
HKD2_k127_9230632_6 cyclic nucleotide binding K10914 - - 0.000000000000000000000005796 108.0
HKD2_k127_9230632_7 PFAM CheW domain protein K03408 - - 0.000000000000000001357 87.0
HKD2_k127_9233000_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.602e-291 917.0
HKD2_k127_9233000_1 PFAM PSP1 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006638 330.0
HKD2_k127_9233000_2 TIGRFAM DNA polymerase III, delta K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003653 287.0
HKD2_k127_9233000_3 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.00000000000000000000000000000000000000000000000000001493 192.0
HKD2_k127_9233000_4 YGGT family K02221 - - 0.0000000000000000000000000000000000003884 143.0
HKD2_k127_9233000_5 membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000104 136.0
HKD2_k127_9233000_6 Belongs to the UPF0235 family K09131 - - 0.000000000000000000003155 96.0
HKD2_k127_9238220_0 C-terminal region of band_7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 467.0
HKD2_k127_9238220_1 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 355.0
HKD2_k127_9238220_3 NfeD-like C-terminal, partner-binding - - - 0.00000000000000000000000000000000000000003559 157.0
HKD2_k127_9254924_0 PFAM Pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1267.0
HKD2_k127_9254924_1 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 0.0 1029.0
HKD2_k127_9254924_10 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000000000003245 94.0
HKD2_k127_9254924_11 Rdx family K07401 - - 0.0000000000000003546 79.0
HKD2_k127_9254924_12 Encoded by K17560 - - 0.0003772 48.0
HKD2_k127_9254924_2 type II secretion system protein E K02454 - - 8.287e-259 813.0
HKD2_k127_9254924_3 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009754 545.0
HKD2_k127_9254924_4 General secretion pathway protein F K02455,K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 500.0
HKD2_k127_9254924_5 glutamate synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 391.0
HKD2_k127_9254924_6 Thiamine biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 374.0
HKD2_k127_9254924_7 PFAM iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000000000001035 190.0
HKD2_k127_9254924_8 HD domain - - - 0.0000000000000000000000000000000000000004952 169.0
HKD2_k127_9254924_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000000000000000002445 124.0
HKD2_k127_9277785_0 Aminoacyl-tRNA editing domain K01881 - 6.1.1.15 3.075e-262 819.0
HKD2_k127_9277785_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 373.0
HKD2_k127_9287214_0 class II (D, K and N) K01893 - 6.1.1.22 6.317e-201 634.0
HKD2_k127_9287214_1 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00003242 49.0
HKD2_k127_9291451_0 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 1.766e-241 751.0
HKD2_k127_9291451_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 2.008e-202 641.0
HKD2_k127_9291451_2 PFAM dihydropteroate synthase DHPS K15023 - 2.1.1.258 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 521.0
HKD2_k127_9291451_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009561 477.0
HKD2_k127_9291451_4 PFAM ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 392.0
HKD2_k127_9291451_5 TIGRFAM acetylornithine and succinylornithine K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 363.0
HKD2_k127_9291451_6 Type I restriction enzyme R protein N terminus (HSDR_N) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001895 237.0
HKD2_k127_9291451_7 OstA-like protein K09774 - - 0.0000000000000000000000000000000000000000000000000005595 190.0
HKD2_k127_9291451_8 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.000000000000000000000000000002597 129.0
HKD2_k127_9317935_0 pfam abc K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006391 316.0
HKD2_k127_9317935_1 Phosphorylase superfamily K00757 - 2.4.2.3 0.000000000000000000000000000000000000000000000000000000000000000000001326 246.0
HKD2_k127_9317935_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000001192 107.0
HKD2_k127_9317935_3 HlyD family secretion protein K02005 - - 0.0000005471 52.0
HKD2_k127_9342479_0 Belongs to the methyltransferase superfamily K07444,K12297 - 2.1.1.173,2.1.1.264 1.124e-226 724.0
HKD2_k127_9342479_1 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006064 432.0
HKD2_k127_9342479_2 6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000003944 209.0
HKD2_k127_9342479_3 NUDIX domain K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000008696 211.0
HKD2_k127_9352183_0 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 470.0
HKD2_k127_9352183_1 PFAM magnesium chelatase ChlI subunit K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 454.0
HKD2_k127_9352183_2 Methyltransferase small domain K15460 - 2.1.1.223 0.00000000000000000000000000000000000000000000000000000000000008566 221.0
HKD2_k127_9352183_3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000001297 219.0
HKD2_k127_9352183_4 PFAM 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000001073 191.0
HKD2_k127_9355741_0 Domain of unknown function (DUF3333) K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 577.0
HKD2_k127_9355741_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 567.0
HKD2_k127_9355741_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005582 462.0
HKD2_k127_9355741_3 TIGRFAM cytochrome c-type biogenesis protein CcsB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 423.0
HKD2_k127_9355741_4 PFAM ResB family protein K07399 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 316.0
HKD2_k127_9355741_5 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 300.0
HKD2_k127_9391551_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 8.099e-201 634.0
HKD2_k127_9391551_1 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 319.0
HKD2_k127_9391551_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000498 218.0
HKD2_k127_9391551_3 cyclic nucleotide binding K10914 - - 0.000000000000000000000000000000000001021 143.0
HKD2_k127_9391551_5 YHS domain - - - 0.00000000000002592 76.0
HKD2_k127_9391551_6 Protein tyrosine kinase K12132 - 2.7.11.1 0.000007923 49.0
HKD2_k127_9392715_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 7.131e-215 679.0
HKD2_k127_9392715_1 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006619 488.0
HKD2_k127_9392715_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 422.0
HKD2_k127_9392715_3 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 396.0
HKD2_k127_9392715_4 - K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000001548 215.0
HKD2_k127_9392715_5 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.000000000000000000000000000000000000000000000000000001881 194.0
HKD2_k127_9392715_6 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000000000000008329 199.0
HKD2_k127_9392715_7 - - - - 0.0000000000000000000000000000001173 129.0
HKD2_k127_9392715_8 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.00000000002853 67.0
HKD2_k127_9404263_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 8.962e-314 994.0
HKD2_k127_9404263_1 Response regulator receiver K01338 - 3.4.21.53 2.77e-240 760.0
HKD2_k127_9404263_10 - - - - 0.0000000000000000002486 92.0
HKD2_k127_9404263_2 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 586.0
HKD2_k127_9404263_3 diguanylate cyclase K13246 - 3.1.4.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 582.0
HKD2_k127_9404263_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 582.0
HKD2_k127_9404263_5 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 469.0
HKD2_k127_9404263_6 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 445.0
HKD2_k127_9404263_7 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008338 339.0
HKD2_k127_9404263_8 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000002093 163.0
HKD2_k127_9404263_9 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000001161 96.0
HKD2_k127_9405299_0 membrane - - - 4.44e-219 695.0
HKD2_k127_9405299_1 S-adenosylmethionine-dependent methyltransferase K06969,K12297 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.173,2.1.1.191,2.1.1.264 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 530.0
HKD2_k127_9405299_2 Uncharacterised conserved protein (DUF2156) K01163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 359.0
HKD2_k127_9405299_3 sensory box sensor histidine kinase VC1084 imported - - - 0.00000000000000000000000000000000000000000000007789 186.0
HKD2_k127_9405299_4 addiction module antidote protein - - - 0.00000000000000000000000002465 108.0
HKD2_k127_9405299_5 Response regulator receiver domain - - - 0.0000000000000000000000001104 121.0
HKD2_k127_9405299_6 Rubrerythrin - - - 0.000000000000000000302 94.0
HKD2_k127_9405299_7 - - - - 0.00000000002646 71.0
HKD2_k127_9405905_0 Elongation factor SelB winged helix K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 491.0
HKD2_k127_9405905_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006578 475.0
HKD2_k127_9405905_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005284 437.0
HKD2_k127_9405905_3 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 306.0
HKD2_k127_9405905_4 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000000000000000000000000000000000000000002561 216.0
HKD2_k127_9405905_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000005166 126.0
HKD2_k127_9405905_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000004077 103.0
HKD2_k127_9437666_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 593.0
HKD2_k127_9437666_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 546.0
HKD2_k127_9437666_10 alginic acid biosynthetic process K10297 - - 0.0001689 46.0
HKD2_k127_9437666_2 TIGRFAM polyphosphate kinase 2, PA0141 family K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004928 436.0
HKD2_k127_9437666_3 TIGRFAM polyphosphate kinase 2, PA0141 family K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 421.0
HKD2_k127_9437666_4 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K04042,K11528 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 400.0
HKD2_k127_9437666_5 WYL domain K13573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 346.0
HKD2_k127_9437666_6 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004595 262.0
HKD2_k127_9437666_7 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000111 261.0
HKD2_k127_9437666_8 Hep Hag repeat protein - - - 0.0000000000000000000000000000000000001498 157.0
HKD2_k127_9437666_9 CHAD domain - - - 0.00006026 50.0
HKD2_k127_9440990_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 5e-324 1000.0
HKD2_k127_9440990_1 AIR synthase related protein, C-terminal domain K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 521.0
HKD2_k127_9440990_2 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 377.0
HKD2_k127_9440990_3 PFAM Radical SAM K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 353.0
HKD2_k127_9440990_4 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 315.0
HKD2_k127_9440990_5 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.00000000000000000000000000000000000000000000000000000000000000009217 229.0
HKD2_k127_9440990_6 PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000001005 206.0
HKD2_k127_9440990_7 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000004763 146.0
HKD2_k127_9440990_8 Protein of unknown function (DUF429) - - - 0.00000000000000000000000000000000001457 145.0
HKD2_k127_9440990_9 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000000007932 105.0
HKD2_k127_9449190_0 ATPsynthase alpha/beta subunit N-term extension K02117 - 3.6.3.14,3.6.3.15 3.038e-220 697.0
HKD2_k127_9449190_1 MlaD protein - - - 9.874e-196 627.0
HKD2_k127_9449190_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 470.0
HKD2_k127_9449190_3 PFAM V-type ATPase 116 kDa K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 441.0
HKD2_k127_9449190_4 Paraquat-inducible protein A K03808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002763 359.0
HKD2_k127_9449190_6 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000000000008727 99.0
HKD2_k127_9449190_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000001609 98.0
HKD2_k127_9449190_8 ATP synthase subunit D K02120 - - 0.000000000000001496 78.0
HKD2_k127_9449190_9 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00000000003112 75.0
HKD2_k127_9499839_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 1.829e-201 644.0
HKD2_k127_9499839_1 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 609.0
HKD2_k127_9499839_10 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004096 287.0
HKD2_k127_9499839_11 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001031 261.0
HKD2_k127_9499839_12 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. - - - 0.0000000000000000000000000000000000000000000000000002325 193.0
HKD2_k127_9499839_13 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000017 163.0
HKD2_k127_9499839_14 tigrfam pas - - - 0.00000001023 68.0
HKD2_k127_9499839_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 559.0
HKD2_k127_9499839_3 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 538.0
HKD2_k127_9499839_4 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 458.0
HKD2_k127_9499839_5 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 426.0
HKD2_k127_9499839_6 PFAM Pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 417.0
HKD2_k127_9499839_7 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008483 350.0
HKD2_k127_9499839_8 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 346.0
HKD2_k127_9499839_9 TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 325.0
HKD2_k127_9504671_0 hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 383.0
HKD2_k127_9504671_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 365.0
HKD2_k127_9504671_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 347.0
HKD2_k127_9504671_3 Hydro-lyase, Fe-S type, tartrate fumarate subfamily, beta subunit K01678 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000008423 255.0
HKD2_k127_9504671_4 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000002133 84.0
HKD2_k127_9579775_0 Fibronectin type III-like domain K05349 - 3.2.1.21 0.0 1059.0
HKD2_k127_9597698_0 Transposase IS116/IS110/IS902 family - - - 0.0000000000000000000000000000000001407 149.0
HKD2_k127_9624424_0 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 3.117e-215 685.0
HKD2_k127_9624424_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 584.0
HKD2_k127_9624424_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 518.0
HKD2_k127_9624424_3 Aldo/keto reductase family K07079 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 413.0
HKD2_k127_9624424_4 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 293.0
HKD2_k127_9624424_5 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002155 280.0
HKD2_k127_9624424_6 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.0000000000000000000000000000001189 138.0
HKD2_k127_9624424_7 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000008023 118.0
HKD2_k127_9624424_8 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.00000001803 64.0
HKD2_k127_9624424_9 - - - - 0.00006219 55.0
HKD2_k127_9629768_0 ABC transporter transmembrane region K12541 - - 1.37e-235 750.0
HKD2_k127_9629768_1 TIGRFAM type I secretion membrane fusion protein, HlyD family K12542 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000925 529.0
HKD2_k127_9629768_2 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000002115 190.0
HKD2_k127_9708707_0 TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0 1226.0
HKD2_k127_9708707_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000001565 72.0
HKD2_k127_9709402_0 Zinc-binding alcohol dehydrogenase family protein K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 464.0
HKD2_k127_9709402_1 Elongation factor SelB winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 338.0
HKD2_k127_9709402_2 exo-alpha-(2->6)-sialidase activity - - - 0.000000000003126 79.0
HKD2_k127_9798879_0 Periplasmic Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001748 284.0
HKD2_k127_9798879_2 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000207 126.0
HKD2_k127_9798879_3 Sulphur transport K07112 - - 0.0000000000000000000441 94.0
HKD2_k127_9798879_4 peptidyl-tyrosine sulfation - - - 0.000000004543 65.0
HKD2_k127_9873807_0 G-rich domain on putative tyrosine kinase K16554 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 568.0
HKD2_k127_9873807_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000003141 158.0
HKD2_k127_9873807_2 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.0000000000000000000000000000000005317 146.0
HKD2_k127_9873807_3 PFAM O-Antigen K18814 - - 0.0000000000000000000000000001353 124.0
HKD2_k127_9873807_4 DnaJ molecular chaperone homology domain K05516 - - 0.000000002116 66.0
HKD2_k127_9893785_0 Endoribonuclease that initiates mRNA decay K18682 - - 2.179e-249 780.0
HKD2_k127_9893785_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 595.0
HKD2_k127_9893785_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 480.0
HKD2_k127_9893785_3 Lysin motif K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005815 452.0
HKD2_k127_9893785_4 ribonuclease BN K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 381.0
HKD2_k127_9893785_5 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000008582 248.0
HKD2_k127_9972937_0 PFAM Polysulphide reductase, NrfD K00185 - - 4.26e-205 644.0
HKD2_k127_9972937_1 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 400.0
HKD2_k127_9972937_2 NAD(P)H dehydrogenase (quinone) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001495 258.0
HKD2_k127_9972937_3 - - - - 0.000000000000000000000000000000000000000000001221 168.0