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Overview

ID MAG01821
Name HKD2_bin.80
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Steroidobacterales
Family Steroidobacteraceae
Genus RPQJ01
Species
Assembly information
Completeness (%) 60.71
Contamination (%) 1.53
GC content (%) 68.0
N50 (bp) 22,414
Genome size (bp) 2,836,412

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2579

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_102922_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1264.0
HKD2_k127_102922_1 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1184.0
HKD2_k127_102922_10 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003915 293.0
HKD2_k127_102922_11 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000002093 264.0
HKD2_k127_102922_12 FeS assembly SUF system protein SufT - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007075 258.0
HKD2_k127_102922_13 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000282 251.0
HKD2_k127_102922_14 FeS assembly protein SufD K09015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009165 262.0
HKD2_k127_102922_15 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.000000000000000000000000000000000000000000000000000002874 202.0
HKD2_k127_102922_16 PFAM Thioredoxin K05838 - - 0.000000000000000000000000000000000000000000000000000007182 200.0
HKD2_k127_102922_17 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K14160 - - 0.0000000000000000000000000000000000000000000000000867 185.0
HKD2_k127_102922_18 salt-induced outer membrane protein K07283 - - 0.0000000000000000000000000000000000000000000000004673 183.0
HKD2_k127_102922_19 Maf-like protein K06287 GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429 - 0.000000000000000000000000000000000000000000000002599 189.0
HKD2_k127_102922_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005161 572.0
HKD2_k127_102922_20 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000000000000000211 156.0
HKD2_k127_102922_21 PFAM Phosphoglycerate mutase K08296 - - 0.00000000000000000000000000000000001202 148.0
HKD2_k127_102922_22 PFAM Rieske 2Fe-2S K05710 - - 0.0000000000000000000000000000009088 127.0
HKD2_k127_102922_23 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000004767 91.0
HKD2_k127_102922_24 Uncharacterized ACR, COG1399 - - - 0.000000000002115 74.0
HKD2_k127_102922_3 Serine dehydratase beta chain K01752 GO:0003674,GO:0003824,GO:0003941,GO:0016829,GO:0016840,GO:0016841 4.3.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 544.0
HKD2_k127_102922_4 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 486.0
HKD2_k127_102922_5 FeS assembly protein SufB K09014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 449.0
HKD2_k127_102922_6 FeS assembly ATPase SufC K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 391.0
HKD2_k127_102922_7 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005329 382.0
HKD2_k127_102922_8 L,D-transpeptidase catalytic domain K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 323.0
HKD2_k127_102922_9 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 306.0
HKD2_k127_109166_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1644.0
HKD2_k127_109166_1 Transcriptional regulatory protein, C terminal - - - 0.0 1082.0
HKD2_k127_109166_10 - - - - 0.0000000000000000000000000000000000000000000003891 173.0
HKD2_k127_109166_11 Uncharacterized protein conserved in bacteria (DUF2219) - - - 0.00000000000000000000000000000000000000000004437 176.0
HKD2_k127_109166_12 Two component transcriptional regulator, LuxR family - - - 0.000000000000000000000000000000000000000005469 162.0
HKD2_k127_109166_13 - - - - 0.000000000000000000000000006687 116.0
HKD2_k127_109166_14 - - - - 0.0000000000000008029 79.0
HKD2_k127_109166_15 - - - - 0.000000000002267 73.0
HKD2_k127_109166_2 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 1.084e-234 738.0
HKD2_k127_109166_3 belongs to the aldehyde dehydrogenase family K09472,K12254 - 1.2.1.54,1.2.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004577 614.0
HKD2_k127_109166_4 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 585.0
HKD2_k127_109166_5 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 552.0
HKD2_k127_109166_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 461.0
HKD2_k127_109166_7 PFAM Patatin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 346.0
HKD2_k127_109166_8 PAS fold K20975 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000003387 275.0
HKD2_k127_109166_9 FIST N domain - - - 0.0000000000000000000000000000000000000000000000003824 194.0
HKD2_k127_111004_0 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 571.0
HKD2_k127_111004_1 of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 488.0
HKD2_k127_111004_2 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid K00020 - 1.1.1.31 0.0000000000000000000002983 102.0
HKD2_k127_1164258_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007834 406.0
HKD2_k127_1164258_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 360.0
HKD2_k127_1164258_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000005945 49.0
HKD2_k127_1239507_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1577.0
HKD2_k127_1239507_1 serine protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 381.0
HKD2_k127_1239507_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 347.0
HKD2_k127_1239507_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000003263 188.0
HKD2_k127_1239507_4 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000000000000001286 180.0
HKD2_k127_1239507_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000009872 151.0
HKD2_k127_1239507_6 Putative zinc-finger - - - 0.0000000000000417 81.0
HKD2_k127_1239507_7 - - - - 0.0000000000007173 75.0
HKD2_k127_124797_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1475.0
HKD2_k127_124797_1 GMC oxidoreductase K00108 - 1.1.99.1 4.324e-282 878.0
HKD2_k127_124797_10 KR domain K00046,K00059 - 1.1.1.100,1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008701 331.0
HKD2_k127_124797_11 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 321.0
HKD2_k127_124797_12 Thioredoxin-like [2Fe-2S] ferredoxin - - - 0.000000000000000000000000000000000000000000000000002178 187.0
HKD2_k127_124797_13 CoA binding domain - - - 0.00000000000000000000000000000000000000000000001564 185.0
HKD2_k127_124797_14 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000001187 167.0
HKD2_k127_124797_15 membrane protein domain - - - 0.00000000000000001528 82.0
HKD2_k127_124797_16 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.0000000000001119 76.0
HKD2_k127_124797_2 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124 - - 6.14e-233 730.0
HKD2_k127_124797_3 FAD dependent oxidoreductase - - - 4.369e-220 728.0
HKD2_k127_124797_4 cobaltochelatase subunit CobS K09882 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 540.0
HKD2_k127_124797_5 cobalt chelatase K09883 - 6.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005706 562.0
HKD2_k127_124797_6 NADPH quinone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006508 419.0
HKD2_k127_124797_7 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 369.0
HKD2_k127_124797_8 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 363.0
HKD2_k127_124797_9 belongs to the aldehyde dehydrogenase family K09472 - 1.2.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 331.0
HKD2_k127_1329499_0 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 296.0
HKD2_k127_1329499_1 phosphorelay signal transduction system K11443 - - 0.0000000000000000000000000000000000005835 142.0
HKD2_k127_1329499_2 Desulfoferrodoxin K05919 - 1.15.1.2 0.00000000001822 70.0
HKD2_k127_1355210_0 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 470.0
HKD2_k127_1355210_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 307.0
HKD2_k127_1355210_10 Endoglucanase K01179 - 3.2.1.4 0.00000000000000000000005951 113.0
HKD2_k127_1355210_12 geranylgeranyl reductase - - - 0.000000000000000000001935 94.0
HKD2_k127_1355210_13 - - - - 0.0000000000000000005084 91.0
HKD2_k127_1355210_14 Bacterial protein of unknown function (DUF883) - - - 0.000000000000000004569 89.0
HKD2_k127_1355210_15 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000003204 93.0
HKD2_k127_1355210_16 Protein involved in cellulose biosynthesis - - - 0.000000000000004334 87.0
HKD2_k127_1355210_17 alpha-L-arabinofuranosidase - - - 0.0000000006036 72.0
HKD2_k127_1355210_18 Fibronectin type 3 domain - - - 0.0000000006641 68.0
HKD2_k127_1355210_19 GDSL-like Lipase/Acylhydrolase family - - - 0.0000004674 62.0
HKD2_k127_1355210_2 Protein of unknown function DUF99 K09120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003278 282.0
HKD2_k127_1355210_20 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000005002 62.0
HKD2_k127_1355210_21 Lysylphosphatidylglycerol synthase TM region - - - 0.00000221 59.0
HKD2_k127_1355210_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002083 252.0
HKD2_k127_1355210_4 NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000008386 228.0
HKD2_k127_1355210_5 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000001265 229.0
HKD2_k127_1355210_6 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000004207 187.0
HKD2_k127_1355210_7 COG0515 Serine threonine protein kinase K08282,K11916,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000009978 199.0
HKD2_k127_1355210_8 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000001563 165.0
HKD2_k127_1355210_9 transcriptional regulator - - - 0.0000000000000000000000000002316 120.0
HKD2_k127_1375885_0 Phosphate transport regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 422.0
HKD2_k127_1375885_1 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007109 370.0
HKD2_k127_1376760_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000429 242.0
HKD2_k127_1376760_1 Bacterial PH domain - - - 0.00000000000000000000000000000000000000000000000000003179 192.0
HKD2_k127_1380787_0 small GTP-binding protein K02355 - - 7.173e-297 924.0
HKD2_k127_1380787_1 Acyl-CoA dehydrogenase K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004067 584.0
HKD2_k127_1380787_10 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 337.0
HKD2_k127_1380787_11 Surface antigen variable number K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 337.0
HKD2_k127_1380787_12 alpha/beta hydrolase fold K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 300.0
HKD2_k127_1380787_13 NADH pyrophosphatase zinc ribbon domain K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 293.0
HKD2_k127_1380787_14 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 297.0
HKD2_k127_1380787_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000671 275.0
HKD2_k127_1380787_16 Part of the ABC transporter FtsEX involved in cellular division K09811 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006294 270.0
HKD2_k127_1380787_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006281 265.0
HKD2_k127_1380787_18 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001434 254.0
HKD2_k127_1380787_19 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005124 250.0
HKD2_k127_1380787_2 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 498.0
HKD2_k127_1380787_20 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000005213 242.0
HKD2_k127_1380787_21 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000005787 247.0
HKD2_k127_1380787_22 Hydrolase of X-linked nucleoside diphosphate N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000002406 232.0
HKD2_k127_1380787_23 Domain of unknown function (DUF1611_C) P-loop domain - - - 0.000000000000000000000000000000000000000000000000000000000000001624 230.0
HKD2_k127_1380787_24 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000003949 224.0
HKD2_k127_1380787_25 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000004146 238.0
HKD2_k127_1380787_26 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000001842 188.0
HKD2_k127_1380787_27 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000004354 189.0
HKD2_k127_1380787_28 Domain of unknown function (DUF4126) - - - 0.0000000000000000000000000000000000000000000003438 173.0
HKD2_k127_1380787_29 periplasmic protein K09797 - - 0.0000000000000000000000000000000000000000000008943 175.0
HKD2_k127_1380787_3 COG1131 ABC-type multidrug transport system, ATPase component K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 416.0
HKD2_k127_1380787_30 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000497 175.0
HKD2_k127_1380787_31 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000001542 139.0
HKD2_k127_1380787_32 Methyltransferase FkbM domain - - - 0.00000000000000000000002341 116.0
HKD2_k127_1380787_33 Regulates arginine biosynthesis genes K03402 - - 0.00000000000000000000002997 105.0
HKD2_k127_1380787_34 Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000786 102.0
HKD2_k127_1380787_35 BON domain - - - 0.00000000000003938 76.0
HKD2_k127_1380787_36 - - - - 0.000003105 54.0
HKD2_k127_1380787_4 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 401.0
HKD2_k127_1380787_5 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008369 421.0
HKD2_k127_1380787_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 355.0
HKD2_k127_1380787_7 RNA polymerase sigma factor RpoH K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 357.0
HKD2_k127_1380787_8 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 358.0
HKD2_k127_1380787_9 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005745 349.0
HKD2_k127_1381126_0 PFAM Magnesium chelatase, ChlI subunit K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 587.0
HKD2_k127_1381126_1 Insecticide toxin TcdB middle/N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 634.0
HKD2_k127_1381126_2 transcriptional regulator K13634 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005067 326.0
HKD2_k127_1393252_0 glutamate synthase K00284 - 1.4.7.1 0.0 1347.0
HKD2_k127_1393252_1 PQQ enzyme repeat K17760 - 1.1.9.1 4.455e-290 907.0
HKD2_k127_1393252_10 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 443.0
HKD2_k127_1393252_11 NAD(P)H-binding K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 399.0
HKD2_k127_1393252_12 Fatty acid desaturase K00496 - 1.14.15.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 357.0
HKD2_k127_1393252_13 Iron-containing alcohol dehydrogenase K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 371.0
HKD2_k127_1393252_14 SBF-like CPA transporter family (DUF4137) K03453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 319.0
HKD2_k127_1393252_15 esterase lipase K14731 - 3.1.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000115 253.0
HKD2_k127_1393252_16 Steryl acetyl hydrolase K14731 - 3.1.1.83 0.0000000000000000000000000000000000000000000000000000000000000000005287 241.0
HKD2_k127_1393252_17 Alkylated DNA repair protein - - - 0.00000000000000000000000000000000000000000000000000000000000006933 224.0
HKD2_k127_1393252_18 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000002014 213.0
HKD2_k127_1393252_19 COG2863 Cytochrome c553 - - - 0.000000000000000000000000000000000000000000000000002156 189.0
HKD2_k127_1393252_2 TonB dependent receptor - - - 4.96e-288 924.0
HKD2_k127_1393252_20 Exopolysaccharide synthesis, ExoD - - - 0.000000000000000000000000000000000000000000000007746 190.0
HKD2_k127_1393252_21 Planctomycete cytochrome C - - - 0.0000000000000000000000000000000000005831 143.0
HKD2_k127_1393252_22 Transcriptional regulator - - - 0.000000000000000000000000000000002172 149.0
HKD2_k127_1393252_23 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000004947 130.0
HKD2_k127_1393252_24 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000005912 117.0
HKD2_k127_1393252_25 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000001182 110.0
HKD2_k127_1393252_26 Transglycosylase associated protein - - - 0.0000000007311 63.0
HKD2_k127_1393252_27 glyoxalase III activity - - - 0.00001341 53.0
HKD2_k127_1393252_3 Belongs to the IlvD Edd family K01687 - 4.2.1.9 3.461e-266 833.0
HKD2_k127_1393252_4 COG3420 Nitrous oxidase accessory protein - - - 2.195e-225 708.0
HKD2_k127_1393252_5 arylsulfatase activity K01130 - 3.1.6.1 1.922e-202 642.0
HKD2_k127_1393252_6 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K20034 - 6.2.1.44 2.778e-198 648.0
HKD2_k127_1393252_7 Hydroxymethylglutaryl-coenzyme A reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 560.0
HKD2_k127_1393252_8 COG1858 Cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 543.0
HKD2_k127_1393252_9 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 453.0
HKD2_k127_1411405_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177,K16877 - 1.17.1.4,1.3.99.8 0.0 1242.0
HKD2_k127_1411405_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0 1054.0
HKD2_k127_1411405_10 - - - - 1.489e-203 654.0
HKD2_k127_1411405_11 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 8.579e-201 640.0
HKD2_k127_1411405_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 602.0
HKD2_k127_1411405_13 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007678 563.0
HKD2_k127_1411405_14 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 558.0
HKD2_k127_1411405_15 Formate dehydrogenase N, transmembrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 522.0
HKD2_k127_1411405_16 Saccharopine dehydrogenase NADP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 527.0
HKD2_k127_1411405_17 CobW/HypB/UreG, nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 513.0
HKD2_k127_1411405_18 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 507.0
HKD2_k127_1411405_19 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 501.0
HKD2_k127_1411405_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 1.581e-314 968.0
HKD2_k127_1411405_20 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 505.0
HKD2_k127_1411405_21 trimethylamine methyltransferase K14083 - 2.1.1.250 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000442 469.0
HKD2_k127_1411405_22 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 456.0
HKD2_k127_1411405_23 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 451.0
HKD2_k127_1411405_24 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 455.0
HKD2_k127_1411405_25 Amino acid permease K11735 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 447.0
HKD2_k127_1411405_26 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 428.0
HKD2_k127_1411405_27 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009254 431.0
HKD2_k127_1411405_28 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 417.0
HKD2_k127_1411405_29 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 415.0
HKD2_k127_1411405_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 1.102e-278 869.0
HKD2_k127_1411405_30 Serine aminopeptidase, S33 K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 409.0
HKD2_k127_1411405_31 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 410.0
HKD2_k127_1411405_32 VWA domain containing CoxE-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 394.0
HKD2_k127_1411405_33 Dimerisation domain of Zinc Transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 370.0
HKD2_k127_1411405_34 XdhC Rossmann domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 354.0
HKD2_k127_1411405_35 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 348.0
HKD2_k127_1411405_36 transcriptional regulator, AraC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 335.0
HKD2_k127_1411405_37 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 344.0
HKD2_k127_1411405_38 Fatty acid hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 334.0
HKD2_k127_1411405_39 COGs COG5616 integral membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 345.0
HKD2_k127_1411405_4 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein K07303 - 1.3.99.16 8.136e-264 832.0
HKD2_k127_1411405_40 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 318.0
HKD2_k127_1411405_41 Belongs to the long-chain O-acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001151 297.0
HKD2_k127_1411405_42 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004826 275.0
HKD2_k127_1411405_43 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000001349 267.0
HKD2_k127_1411405_44 Formate dehydrogenase gamma subunit K00127 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002673 268.0
HKD2_k127_1411405_45 Necessary for formate dehydrogenase activity K02380 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009642 269.0
HKD2_k127_1411405_46 helix_turn_helix isocitrate lyase regulation K13641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004315 268.0
HKD2_k127_1411405_47 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009529 278.0
HKD2_k127_1411405_48 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000001308 260.0
HKD2_k127_1411405_49 MafB19-like deaminase K01485 - 3.5.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002039 255.0
HKD2_k127_1411405_5 DNA polymerase X family K02347 - - 1.11e-221 701.0
HKD2_k127_1411405_50 EamA-like transporter family K15268 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006866 256.0
HKD2_k127_1411405_51 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009492 259.0
HKD2_k127_1411405_52 YHS domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001867 254.0
HKD2_k127_1411405_53 enoyl-CoA hydratase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000001186 247.0
HKD2_k127_1411405_54 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001595 248.0
HKD2_k127_1411405_55 HTH domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000517 245.0
HKD2_k127_1411405_56 Biopolymer transporter ExbB K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000001234 248.0
HKD2_k127_1411405_57 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000002494 233.0
HKD2_k127_1411405_58 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000000006349 234.0
HKD2_k127_1411405_59 Aminotransferase K03430 - 2.6.1.37 0.00000000000000000000000000000000000000000000000000000000000000003167 246.0
HKD2_k127_1411405_6 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 3.683e-219 691.0
HKD2_k127_1411405_60 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000001219 228.0
HKD2_k127_1411405_61 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000003317 222.0
HKD2_k127_1411405_62 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000005818 220.0
HKD2_k127_1411405_63 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.00000000000000000000000000000000000000000000000000000000001614 224.0
HKD2_k127_1411405_64 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141,K19190 - 1.1.1.328,2.7.7.76 0.00000000000000000000000000000000000000000000000000000000007536 212.0
HKD2_k127_1411405_65 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.000000000000000000000000000000000000000000000000000000000323 211.0
HKD2_k127_1411405_66 Domain of unknown function (DUF4382) - - - 0.000000000000000000000000000000000000000000000000000000308 207.0
HKD2_k127_1411405_67 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000006471 200.0
HKD2_k127_1411405_68 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 0.00000000000000000000000000000000000000000000000000008697 192.0
HKD2_k127_1411405_69 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000002135 189.0
HKD2_k127_1411405_7 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 6.023e-216 696.0
HKD2_k127_1411405_70 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.0000000000000000000000000000000000000000000000000795 186.0
HKD2_k127_1411405_71 Cytochrome c - - - 0.000000000000000000000000000000000000000000000002079 181.0
HKD2_k127_1411405_72 Cache domain - - - 0.00000000000000000000000000000000000000000000001136 186.0
HKD2_k127_1411405_73 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000012 177.0
HKD2_k127_1411405_74 - - - - 0.000000000000000000000000000000000000000453 166.0
HKD2_k127_1411405_75 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.0000000000000000000000000000000000000005272 153.0
HKD2_k127_1411405_76 PFAM Exonuclease RNase T and DNA polymerase III K02342 - 2.7.7.7 0.000000000000000000000000000000000000003412 158.0
HKD2_k127_1411405_77 META domain - - - 0.0000000000000000000000000000000000002418 155.0
HKD2_k127_1411405_78 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - - 0.00000000000000000000000000000000001866 143.0
HKD2_k127_1411405_79 Protein of unknown function, DUF485 - - - 0.0000000000000000000000000000000001539 151.0
HKD2_k127_1411405_8 Translation Elongation Factor K03833 - - 5.003e-206 674.0
HKD2_k127_1411405_80 Protein of unknown function (DUF1232) - - - 0.0000000000000000000000000000000006213 138.0
HKD2_k127_1411405_81 glyoxalase III activity - - - 0.00000000000000000000000000000001445 143.0
HKD2_k127_1411405_82 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000003915 135.0
HKD2_k127_1411405_83 Protein of unknown function (DUF3175) - - - 0.000000000000000000000000000001824 124.0
HKD2_k127_1411405_85 AntiSigma factor - - - 0.00000000000000000000000001063 121.0
HKD2_k127_1411405_86 HD domain - - - 0.0000000000000000000001279 109.0
HKD2_k127_1411405_87 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000001604 108.0
HKD2_k127_1411405_88 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000152 100.0
HKD2_k127_1411405_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.285e-205 648.0
HKD2_k127_1411405_90 Polysaccharide biosynthesis protein - - - 0.000000000000005809 88.0
HKD2_k127_1411405_92 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000001657 72.0
HKD2_k127_1411405_93 Cupin 2, conserved barrel domain protein K21700 - - 0.000001929 56.0
HKD2_k127_1413509_0 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 7.25e-279 880.0
HKD2_k127_1413509_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 546.0
HKD2_k127_1413509_2 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005343 484.0
HKD2_k127_1413509_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 382.0
HKD2_k127_1413509_4 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 345.0
HKD2_k127_1413509_5 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 340.0
HKD2_k127_1413509_6 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 311.0
HKD2_k127_1413509_7 - - - - 0.000000000000000000000000000000000000000000000000000000000005198 211.0
HKD2_k127_1413509_8 - - - - 0.000000000000000000000000000422 120.0
HKD2_k127_1416019_0 metal-dependent hydrolase with the TIM-barrel fold - - - 3.951e-248 777.0
HKD2_k127_1416019_1 FAD dependent oxidoreductase K06954 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 588.0
HKD2_k127_1416019_10 Belongs to the UPF0178 family K09768 - - 0.00000000000000000000000000000000000000000000000007167 181.0
HKD2_k127_1416019_11 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000001504 135.0
HKD2_k127_1416019_12 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000004822 108.0
HKD2_k127_1416019_13 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000004301 97.0
HKD2_k127_1416019_2 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007765 540.0
HKD2_k127_1416019_3 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 493.0
HKD2_k127_1416019_4 Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 431.0
HKD2_k127_1416019_5 Hypothetical methyltransferase K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 389.0
HKD2_k127_1416019_6 Protein of unknown function (DUF1365) K09701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 331.0
HKD2_k127_1416019_7 PFAM regulatory protein, MerR K22491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008194 297.0
HKD2_k127_1416019_8 3-oxo-5-alpha-steroid 4-dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003648 306.0
HKD2_k127_1416019_9 Lipocalin-like domain K03098 - - 0.0000000000000000000000000000000000000000000000000000000000000000001258 247.0
HKD2_k127_1418119_0 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 359.0
HKD2_k127_1418119_1 sterol desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009794 275.0
HKD2_k127_1418119_2 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000003216 157.0
HKD2_k127_1418119_3 membrane - - - 0.000000000000000000000000000000000505 134.0
HKD2_k127_1418119_4 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000009145 76.0
HKD2_k127_1513911_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.0 1631.0
HKD2_k127_1513911_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1038.0
HKD2_k127_1513911_10 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 384.0
HKD2_k127_1513911_11 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009863 358.0
HKD2_k127_1513911_12 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 300.0
HKD2_k127_1513911_13 COG2202 FOG PAS PAC domain K21025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 311.0
HKD2_k127_1513911_14 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 293.0
HKD2_k127_1513911_15 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002282 261.0
HKD2_k127_1513911_16 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000495 255.0
HKD2_k127_1513911_17 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000006272 251.0
HKD2_k127_1513911_18 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000002738 233.0
HKD2_k127_1513911_19 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000874 196.0
HKD2_k127_1513911_2 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.588e-307 953.0
HKD2_k127_1513911_20 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000003364 141.0
HKD2_k127_1513911_21 - - - - 0.0000000000000000000002703 104.0
HKD2_k127_1513911_22 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.00000000000000001249 85.0
HKD2_k127_1513911_3 ABC transporter - - - 8.702e-295 913.0
HKD2_k127_1513911_4 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 7.51e-265 840.0
HKD2_k127_1513911_5 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.284e-208 656.0
HKD2_k127_1513911_6 Cysteine-rich domain - - - 2.464e-204 645.0
HKD2_k127_1513911_7 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 484.0
HKD2_k127_1513911_8 Histidine ammonia-lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 456.0
HKD2_k127_1513911_9 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 409.0
HKD2_k127_1531127_0 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008758 522.0
HKD2_k127_1531127_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006246 473.0
HKD2_k127_1531127_2 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000001844 169.0
HKD2_k127_1543777_0 TGS domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 389.0
HKD2_k127_1543777_1 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 349.0
HKD2_k127_1543777_2 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009752 336.0
HKD2_k127_1543777_3 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000007143 155.0
HKD2_k127_1543777_4 amine dehydrogenase activity - - - 0.00000000000000000000000004887 110.0
HKD2_k127_1553749_0 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 593.0
HKD2_k127_1553749_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 464.0
HKD2_k127_1553749_2 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000001517 218.0
HKD2_k127_1553749_3 Thioredoxin-like - - - 0.0000000000000000000000000000000000003291 145.0
HKD2_k127_1553749_4 Protein of unknown function (DUF3570) - - - 0.000000000000000000000000000000000000553 154.0
HKD2_k127_1553749_5 Domain of unknown function (DUF4266) - - - 0.000000000000000000000122 100.0
HKD2_k127_1553749_7 - - - - 0.000000000000000005592 89.0
HKD2_k127_156400_0 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784,K12448 - 5.1.3.2,5.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005356 469.0
HKD2_k127_156400_1 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 413.0
HKD2_k127_156400_2 guanyl-nucleotide exchange factor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 374.0
HKD2_k127_156400_3 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 353.0
HKD2_k127_156400_4 heme-binding sites - - - 0.000000000000000001577 101.0
HKD2_k127_156400_5 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000004984 74.0
HKD2_k127_1588308_0 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 546.0
HKD2_k127_1588308_1 Belongs to the peptidase S11 family K07262 - - 0.000000000000000000000001823 112.0
HKD2_k127_1588308_2 - - - - 0.00000000000000000007866 91.0
HKD2_k127_1592438_0 Domain of unknown function (DUF4445) - - - 1.693e-223 700.0
HKD2_k127_1592438_1 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 576.0
HKD2_k127_1592438_2 Vitamin B12 dependent methionine synthase activation K00548,K15023 - 2.1.1.13,2.1.1.258 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 493.0
HKD2_k127_1592438_3 cobalamin binding K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007461 354.0
HKD2_k127_1592438_4 Protein of unknown function (DUF1638) - - - 0.000000000000000000000000000000000000000000000000000000000000000001609 243.0
HKD2_k127_1592438_5 Methylene-tetrahydrofolate reductase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000002558 228.0
HKD2_k127_1592438_6 Virulence factor - - - 0.000000000000000000000000000000007037 139.0
HKD2_k127_1633836_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1134.0
HKD2_k127_164756_0 Flavin containing amine oxidoreductase - - - 2.655e-248 775.0
HKD2_k127_164756_1 PFAM glucose-methanol-choline oxidoreductase K03333 - 1.1.3.6 8.944e-198 633.0
HKD2_k127_164756_10 negative regulation of transcription, DNA-templated K10947 - - 0.00000000000000000000000000000000000008352 145.0
HKD2_k127_164756_11 (twin-arginine translocation) pathway signal - - - 0.000000000000000000000000000000000003784 156.0
HKD2_k127_164756_12 SnoaL-like domain K06893 - - 0.00000000000000000000000000000000001554 139.0
HKD2_k127_164756_13 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 GO:0001505,GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0006113,GO:0006575,GO:0006577,GO:0006578,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008812,GO:0009058,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0019285,GO:0019695,GO:0031455,GO:0031456,GO:0034641,GO:0042133,GO:0042398,GO:0044237,GO:0044249,GO:0044271,GO:0050896,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 1.1.99.1 0.0000000000000000000000000001316 117.0
HKD2_k127_164756_14 - - - - 0.00000000000002497 85.0
HKD2_k127_164756_15 positive regulation of macromolecule biosynthetic process K03973 - - 0.00000001478 63.0
HKD2_k127_164756_2 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009955 512.0
HKD2_k127_164756_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 492.0
HKD2_k127_164756_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 331.0
HKD2_k127_164756_5 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006599 344.0
HKD2_k127_164756_6 Alcohol dehydrogenase GroES-like domain K00004 - 1.1.1.303,1.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 304.0
HKD2_k127_164756_7 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008218 273.0
HKD2_k127_164756_8 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001486 273.0
HKD2_k127_164756_9 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000105 269.0
HKD2_k127_1667724_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008905 569.0
HKD2_k127_1667724_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 475.0
HKD2_k127_1667724_2 Glutamyl-tRNA amidotransferase K09117 - - 0.000000003542 58.0
HKD2_k127_1693362_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 5.118e-281 880.0
HKD2_k127_1693362_1 Dehydratase family K01687 - 4.2.1.9 7.162e-250 783.0
HKD2_k127_1693362_10 TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbB K03559 - - 0.0000000000000000000000000000000000000000000000002908 179.0
HKD2_k127_1693362_11 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000001272 169.0
HKD2_k127_1693362_12 - - - - 0.00000000000000000000000000000000000000002956 161.0
HKD2_k127_1693362_13 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000000000000000000000007662 154.0
HKD2_k127_1693362_14 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000525 161.0
HKD2_k127_1693362_2 COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 578.0
HKD2_k127_1693362_3 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 563.0
HKD2_k127_1693362_4 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 457.0
HKD2_k127_1693362_5 PFAM Pyruvate carboxyltransferase K01640,K18314 - 4.1.3.4,4.1.3.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 397.0
HKD2_k127_1693362_6 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 359.0
HKD2_k127_1693362_7 PFAM MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002419 268.0
HKD2_k127_1693362_8 Isochorismatase family K13995 - 3.5.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000006369 256.0
HKD2_k127_1693362_9 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000001089 192.0
HKD2_k127_1697008_0 cAMP biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000005321 201.0
HKD2_k127_1697008_1 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000002191 167.0
HKD2_k127_1697008_2 Glutathione S-transferase, C-terminal domain K04097 - 2.5.1.18,5.3.99.2 0.000000000000000000000000000001216 131.0
HKD2_k127_1697008_3 - - - - 0.000002733 55.0
HKD2_k127_1697008_4 - - - - 0.000006894 55.0
HKD2_k127_172241_0 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 530.0
HKD2_k127_172241_1 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 526.0
HKD2_k127_172241_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009665 300.0
HKD2_k127_172241_3 Two component transcriptional regulator, winged helix family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000648 277.0
HKD2_k127_172241_4 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000006856 198.0
HKD2_k127_172241_5 spectrin binding K15502,K15503,K16717 GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0031974,GO:0031981,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0070013 - 0.00000000000000000000000000005886 134.0
HKD2_k127_172241_6 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000157 111.0
HKD2_k127_172241_7 TIGRFAM Cytochrome c-type biogenesis protein CcmI K02200 - - 0.00000000636 67.0
HKD2_k127_172241_8 - - - - 0.00002536 53.0
HKD2_k127_17261_0 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 571.0
HKD2_k127_17261_1 Glycosyl transferase family group 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009548 526.0
HKD2_k127_17261_2 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009699 364.0
HKD2_k127_17261_3 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000005039 162.0
HKD2_k127_17261_4 Acyltransferase family - - - 0.00000000000000000000000000000000000005029 157.0
HKD2_k127_17261_5 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000009248 149.0
HKD2_k127_17261_6 SnoaL-like domain - - - 0.000000000000001351 82.0
HKD2_k127_17261_7 Protein of unknown function (DUF2845) - - - 0.0003359 49.0
HKD2_k127_174784_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 1.895e-211 664.0
HKD2_k127_174784_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 461.0
HKD2_k127_174784_2 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 399.0
HKD2_k127_174784_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000005103 204.0
HKD2_k127_174784_4 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.0000000000000000000000000000000000000615 152.0
HKD2_k127_1750151_0 TonB dependent receptor K02014 - - 3.36e-272 863.0
HKD2_k127_1750151_1 Glycosyl hydrolases family 15 - - - 5.346e-222 705.0
HKD2_k127_1750151_10 aminopeptidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 550.0
HKD2_k127_1750151_11 dipeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 508.0
HKD2_k127_1750151_12 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00819,K09251 - 2.6.1.13,2.6.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 346.0
HKD2_k127_1750151_13 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 331.0
HKD2_k127_1750151_14 Peptidase C26 K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007565 287.0
HKD2_k127_1750151_15 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002358 270.0
HKD2_k127_1750151_16 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002237 255.0
HKD2_k127_1750151_17 Phospholipase D. Active site motifs. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007389 259.0
HKD2_k127_1750151_18 PFAM Inositol monophosphatase K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.0000000000000000000000000000000000000000000000000000000000002453 226.0
HKD2_k127_1750151_19 translation initiation factor activity K03496,K09000 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000004602 226.0
HKD2_k127_1750151_2 to Mus musculus sphingosine-1-phosphate lyase Sgpl1 SWALL O54955 (EMBL AF036894) (568 aa) fasta scores E() K01634 - 4.1.2.27 1.012e-221 695.0
HKD2_k127_1750151_20 Histidine kinase K05962 - 2.7.13.1 0.000000000000000000000000000000000000000000000000003 199.0
HKD2_k127_1750151_21 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000000000000000000000003333 190.0
HKD2_k127_1750151_22 - - - - 0.00000000000000000000000000000000000000002856 159.0
HKD2_k127_1750151_23 GEPR COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000002215 141.0
HKD2_k127_1750151_24 Transcription factor zinc-finger K09981 - - 0.0000000000000000000000000004778 117.0
HKD2_k127_1750151_25 - - - - 0.000000000000000000000000001611 113.0
HKD2_k127_1750151_26 SCP-2 sterol transfer family - - - 0.00000000000000000000000003903 115.0
HKD2_k127_1750151_27 response regulator - - - 0.000000000000000000002058 98.0
HKD2_k127_1750151_28 BON domain - - - 0.00000000000000002706 86.0
HKD2_k127_1750151_29 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000005101 76.0
HKD2_k127_1750151_3 FGGY family of carbohydrate kinase, N-terminal domain protein K00854 - 2.7.1.17 1.089e-220 695.0
HKD2_k127_1750151_30 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures - - - 0.0001629 52.0
HKD2_k127_1750151_4 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 2.438e-214 702.0
HKD2_k127_1750151_5 Aldehyde dehydrogenase family - - - 5.262e-214 676.0
HKD2_k127_1750151_6 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 2.717e-199 638.0
HKD2_k127_1750151_7 amino acid - - - 1.333e-195 624.0
HKD2_k127_1750151_8 Phospholipase D. Active site motifs. K06132 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 584.0
HKD2_k127_1750151_9 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 556.0
HKD2_k127_1765021_0 AAA domain - - - 1.497e-248 793.0
HKD2_k127_1765021_1 PFAM AMP-dependent synthetase and ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 499.0
HKD2_k127_1765021_2 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000002735 259.0
HKD2_k127_1765021_3 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004162 254.0
HKD2_k127_1765021_4 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000000000000000006015 239.0
HKD2_k127_1765021_5 - - - - 0.0000000000000000000000000000000000003228 156.0
HKD2_k127_1765021_6 Universal stress protein family - - - 0.00000000000000003897 87.0
HKD2_k127_1765021_7 Protein of unknown function (DUF2905) - - - 0.00000000000001251 84.0
HKD2_k127_1765021_8 Phosphoesterase K07095 - - 0.000000000004222 74.0
HKD2_k127_1770029_0 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 531.0
HKD2_k127_1770029_1 Histidine kinase K02668 - 2.7.13.3 0.00000000000000000003183 93.0
HKD2_k127_1770029_2 GtrA-like protein - - - 0.000000000000001118 85.0
HKD2_k127_1840645_0 Homospermidine synthase K00808 - 2.5.1.44 6.152e-231 722.0
HKD2_k127_1840645_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 329.0
HKD2_k127_1840645_2 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 304.0
HKD2_k127_1840645_3 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002065 279.0
HKD2_k127_1840645_4 TPM domain K06872 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003442 266.0
HKD2_k127_1840645_5 Methyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000608 266.0
HKD2_k127_1840645_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000000193 216.0
HKD2_k127_1840645_7 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000001151 213.0
HKD2_k127_1840645_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000001205 160.0
HKD2_k127_1840645_9 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000007452 111.0
HKD2_k127_1918131_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1118.0
HKD2_k127_1918131_1 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003984 611.0
HKD2_k127_1918131_10 D-alanyl-D-alanine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000003427 225.0
HKD2_k127_1918131_11 WHG domain - - - 0.0000000000000000000000000000000000000000000000000000008362 199.0
HKD2_k127_1918131_12 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000004265 193.0
HKD2_k127_1918131_13 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000001266 196.0
HKD2_k127_1918131_14 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000002144 194.0
HKD2_k127_1918131_15 MlaD protein K02067 - - 0.00000000000000000000000000000000001635 149.0
HKD2_k127_1918131_16 Ion channel - - - 0.000000000000000000000000000000002322 135.0
HKD2_k127_1918131_17 Putative prokaryotic signal transducing protein - - - 0.0000000000000000000000001737 108.0
HKD2_k127_1918131_18 transport system, auxiliary component K18480 - - 0.00000000000004438 81.0
HKD2_k127_1918131_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 554.0
HKD2_k127_1918131_3 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 428.0
HKD2_k127_1918131_4 Sodium/calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 386.0
HKD2_k127_1918131_5 (ABC) transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006443 294.0
HKD2_k127_1918131_6 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001592 267.0
HKD2_k127_1918131_7 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005179 256.0
HKD2_k127_1918131_8 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000001184 254.0
HKD2_k127_1918131_9 Thioesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000002355 236.0
HKD2_k127_196183_0 Sortilin, neurotensin receptor 3, - - - 0.0 1255.0
HKD2_k127_196183_1 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 5.196e-276 874.0
HKD2_k127_196183_10 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 460.0
HKD2_k127_196183_11 PFAM Peptidase family M48 K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 443.0
HKD2_k127_196183_12 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 432.0
HKD2_k127_196183_13 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 427.0
HKD2_k127_196183_14 amino acid peptide transporter K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008867 420.0
HKD2_k127_196183_15 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 365.0
HKD2_k127_196183_16 NADP-dependent oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004051 342.0
HKD2_k127_196183_17 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 329.0
HKD2_k127_196183_18 electron transfer flavoprotein beta subunit K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 329.0
HKD2_k127_196183_19 Preprotein translocase subunit TatD K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 317.0
HKD2_k127_196183_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 9.563e-268 833.0
HKD2_k127_196183_20 Belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 307.0
HKD2_k127_196183_21 Protein of unknown function (DUF1345) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 303.0
HKD2_k127_196183_22 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 297.0
HKD2_k127_196183_23 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004568 269.0
HKD2_k127_196183_24 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001008 253.0
HKD2_k127_196183_25 Peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000003553 226.0
HKD2_k127_196183_26 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000008873 216.0
HKD2_k127_196183_27 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000000678 184.0
HKD2_k127_196183_28 WLM domain K07043 - - 0.00000000000000000000000000000000000000002059 162.0
HKD2_k127_196183_29 protein conserved in bacteria - - - 0.00000000000000000000000000000001791 132.0
HKD2_k127_196183_3 Aminopeptidase puromycin sensitive - - - 6.726e-234 775.0
HKD2_k127_196183_30 DoxX - - - 0.00000000000000000000000000000006002 139.0
HKD2_k127_196183_32 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.00000000000000000000000002006 117.0
HKD2_k127_196183_33 Putative DNA-binding domain - - - 0.000000000000000000000003048 113.0
HKD2_k127_196183_34 Predicted integral membrane protein (DUF2282) - - - 0.00000000000000000000003572 104.0
HKD2_k127_196183_35 - - - - 0.00000000000000000001721 105.0
HKD2_k127_196183_36 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000003518 82.0
HKD2_k127_196183_37 NERD domain protein - - - 0.000000003418 69.0
HKD2_k127_196183_4 PFAM amidohydrolase K01464,K01466 - 3.5.2.2,3.5.2.5 1.467e-220 693.0
HKD2_k127_196183_5 peptidase M20 - - - 3.652e-211 665.0
HKD2_k127_196183_6 NAD(P)-binding Rossmann-like domain K00316 - 1.5.99.6 3.028e-207 662.0
HKD2_k127_196183_7 GtrA-like protein K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007293 554.0
HKD2_k127_196183_8 Permease family K06901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 557.0
HKD2_k127_196183_9 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 478.0
HKD2_k127_2119928_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 3.023e-307 954.0
HKD2_k127_2119928_1 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 1.201e-296 920.0
HKD2_k127_2119928_10 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 580.0
HKD2_k127_2119928_11 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008048 528.0
HKD2_k127_2119928_12 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 519.0
HKD2_k127_2119928_13 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 514.0
HKD2_k127_2119928_14 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 451.0
HKD2_k127_2119928_15 Arabinose 5-phosphate isomerase K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005494 431.0
HKD2_k127_2119928_16 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005682 425.0
HKD2_k127_2119928_17 ABC transporter, ATP-binding protein K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 355.0
HKD2_k127_2119928_18 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 319.0
HKD2_k127_2119928_19 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 312.0
HKD2_k127_2119928_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.664e-254 790.0
HKD2_k127_2119928_20 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006274 280.0
HKD2_k127_2119928_21 Cytochrome C1 family K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002031 263.0
HKD2_k127_2119928_22 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000008619 258.0
HKD2_k127_2119928_23 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000003206 248.0
HKD2_k127_2119928_24 COG0625 Glutathione S-transferase K03599 GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000008592 211.0
HKD2_k127_2119928_25 peptidase S16, lon K07157 - - 0.00000000000000000000000000000000000000000000000000000007343 202.0
HKD2_k127_2119928_26 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000001225 201.0
HKD2_k127_2119928_27 TraB family K09973 - - 0.00000000000000000000000000000000000000000000000000000321 209.0
HKD2_k127_2119928_28 glycosyl - - - 0.0000000000000000000000000000000000000000000000000001161 199.0
HKD2_k127_2119928_29 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000005454 169.0
HKD2_k127_2119928_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657 2.5.1.6 9.622e-216 674.0
HKD2_k127_2119928_30 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.0000000000000000000000000000000000000009494 161.0
HKD2_k127_2119928_31 modulation protein K05808 - - 0.000000000000000000000000000001327 126.0
HKD2_k127_2119928_32 Belongs to the BolA IbaG family - - - 0.000000000000000000005958 94.0
HKD2_k127_2119928_33 - - - - 0.00000000000000005149 90.0
HKD2_k127_2119928_34 COG2969 Stringent starvation protein B K03600 GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904 - 0.00000000000000009652 91.0
HKD2_k127_2119928_35 - - - - 0.00000000000001696 81.0
HKD2_k127_2119928_36 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm K09774 - - 0.000000001952 66.0
HKD2_k127_2119928_37 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA K11719 - - 0.000003172 57.0
HKD2_k127_2119928_38 iron ion binding - - - 0.0004005 51.0
HKD2_k127_2119928_4 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 6.158e-211 662.0
HKD2_k127_2119928_5 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 2.509e-201 629.0
HKD2_k127_2119928_6 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 2.174e-196 619.0
HKD2_k127_2119928_7 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 1.314e-195 617.0
HKD2_k127_2119928_8 Aminotransferase K01845 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 610.0
HKD2_k127_2119928_9 protein conserved in bacteria K09989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005048 589.0
HKD2_k127_2144466_0 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 482.0
HKD2_k127_2144466_1 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 472.0
HKD2_k127_2144466_10 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000172 181.0
HKD2_k127_2144466_11 EamA-like transporter family - - - 0.000000000000000000000000000000000000000002743 161.0
HKD2_k127_2144466_12 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.0000004941 56.0
HKD2_k127_2144466_13 Transposase - - - 0.0005311 42.0
HKD2_k127_2144466_2 Belongs to the beta-ketoacyl-ACP synthases family K14660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 442.0
HKD2_k127_2144466_3 Histidine kinase K07649 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 445.0
HKD2_k127_2144466_4 Peptidogalycan biosysnthesis/recognition - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 425.0
HKD2_k127_2144466_5 outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 421.0
HKD2_k127_2144466_6 Esterase lipase K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005295 409.0
HKD2_k127_2144466_7 abc transporter atp-binding protein K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 341.0
HKD2_k127_2144466_8 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 312.0
HKD2_k127_2144466_9 Secretion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001181 258.0
HKD2_k127_2148475_0 TonB-dependent Receptor Plug Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 453.0
HKD2_k127_2148475_1 Hypothetical methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000008514 213.0
HKD2_k127_2148475_2 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000005365 65.0
HKD2_k127_223017_0 PFAM PrkA AAA K07180 - - 7.021e-300 934.0
HKD2_k127_223017_1 CHASE2 domain protein - - - 1.193e-232 735.0
HKD2_k127_223017_10 Transcription factor zinc-finger K09981 - - 0.00000468 54.0
HKD2_k127_223017_11 - - - - 0.00002097 54.0
HKD2_k127_223017_2 SpoVR family K06415 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 529.0
HKD2_k127_223017_3 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 411.0
HKD2_k127_223017_4 Belongs to the UPF0229 family K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 392.0
HKD2_k127_223017_5 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004186 399.0
HKD2_k127_223017_6 PGAP1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 387.0
HKD2_k127_223017_7 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000891 307.0
HKD2_k127_223017_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000001156 201.0
HKD2_k127_223017_9 Transcriptional regulator K07726 - - 0.000000000000000000006403 96.0
HKD2_k127_2315464_0 Predicted Permease Membrane Region K07085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 479.0
HKD2_k127_2315464_1 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 350.0
HKD2_k127_2315464_2 Predicted Permease Membrane Region K07085 - - 0.0000000000000000000000000000000000000002977 152.0
HKD2_k127_2426164_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1088.0
HKD2_k127_2426164_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.131e-311 968.0
HKD2_k127_2426164_10 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009857 556.0
HKD2_k127_2426164_11 acyl-CoA transferases carnitine dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 524.0
HKD2_k127_2426164_12 aminotransferase K14260 - 2.6.1.2,2.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004996 480.0
HKD2_k127_2426164_13 GMP synthase (glutamine-hydrolyzing) activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 479.0
HKD2_k127_2426164_14 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005002 470.0
HKD2_k127_2426164_15 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 450.0
HKD2_k127_2426164_16 component I K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 437.0
HKD2_k127_2426164_17 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 433.0
HKD2_k127_2426164_18 COG1448 Aspartate tyrosine aromatic aminotransferase K00813,K00832 - 2.6.1.1,2.6.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 399.0
HKD2_k127_2426164_19 transporter, permease K02033,K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 391.0
HKD2_k127_2426164_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 5.244e-291 916.0
HKD2_k127_2426164_20 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 375.0
HKD2_k127_2426164_21 Belongs to the bacterial solute-binding protein 9 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 352.0
HKD2_k127_2426164_22 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004996 384.0
HKD2_k127_2426164_23 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008572 345.0
HKD2_k127_2426164_24 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 339.0
HKD2_k127_2426164_25 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 341.0
HKD2_k127_2426164_27 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007173 329.0
HKD2_k127_2426164_28 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 334.0
HKD2_k127_2426164_29 Queuosine biosynthesis protein QueC K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 323.0
HKD2_k127_2426164_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 5.928e-248 783.0
HKD2_k127_2426164_30 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 323.0
HKD2_k127_2426164_31 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 319.0
HKD2_k127_2426164_32 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 292.0
HKD2_k127_2426164_33 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002627 276.0
HKD2_k127_2426164_34 PFAM MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004856 263.0
HKD2_k127_2426164_35 PFAM Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006281 265.0
HKD2_k127_2426164_36 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003824 256.0
HKD2_k127_2426164_37 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000007612 257.0
HKD2_k127_2426164_38 Oligopeptide/dipeptide transporter, C-terminal region K10823 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000001065 253.0
HKD2_k127_2426164_39 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000721 234.0
HKD2_k127_2426164_4 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 - 3.1.11.5 8.613e-240 782.0
HKD2_k127_2426164_40 - - - - 0.00000000000000000000000000000000000000000000000000000000001598 217.0
HKD2_k127_2426164_41 Glycine zipper 2TM domain - - - 0.000000000000000000000000000000000000000000000000000000004458 207.0
HKD2_k127_2426164_42 general secretion pathway protein G K02456 - - 0.0000000000000000000000000000000000000000000000000000003091 198.0
HKD2_k127_2426164_43 Amino-transferase class IV K02619 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008696,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042558,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 4.1.3.38 0.00000000000000000000000000000000000000000000000000002354 202.0
HKD2_k127_2426164_44 COG3156 Type II secretory pathway, component PulK K02460 - - 0.00000000000000000000000000000000000000000000000007316 198.0
HKD2_k127_2426164_45 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression K06204 - - 0.0000000000000000000000000000000000000000000000008417 183.0
HKD2_k127_2426164_46 Pilus assembly protein PilZ K02676 - - 0.00000000000000000000000000000000000000000000003423 174.0
HKD2_k127_2426164_47 DNA polymerase III subunit delta K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000434 184.0
HKD2_k127_2426164_48 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000004816 169.0
HKD2_k127_2426164_49 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000003749 166.0
HKD2_k127_2426164_5 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 9.982e-227 720.0
HKD2_k127_2426164_50 Biopolymer transport protein K03560 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000234 151.0
HKD2_k127_2426164_51 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000003173 153.0
HKD2_k127_2426164_52 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000001356 153.0
HKD2_k127_2426164_53 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000007973 146.0
HKD2_k127_2426164_54 TIGRFAM Polyhydroxyalkanoate synthesis repressor PhaR - - - 0.0000000000000000000000000000000005959 140.0
HKD2_k127_2426164_55 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.000000000000000000000000000000002224 145.0
HKD2_k127_2426164_56 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000002564 131.0
HKD2_k127_2426164_57 General secretion pathway protein J K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.000000000000000000000000000000005715 141.0
HKD2_k127_2426164_58 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000001891 127.0
HKD2_k127_2426164_59 REDY-like protein HapK - - - 0.00000000000000000000000000000006966 128.0
HKD2_k127_2426164_6 Participates in both transcription termination and antitermination K02600 - - 2.048e-222 699.0
HKD2_k127_2426164_60 Protein of unknown function (DUF1622) - - - 0.000000000000000000000000000004534 124.0
HKD2_k127_2426164_61 Rhomboid family - - - 0.00000000000000000000000000002426 125.0
HKD2_k127_2426164_62 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000002836 106.0
HKD2_k127_2426164_63 PFAM PsiF repeat protein - - - 0.00000000000000000000003872 105.0
HKD2_k127_2426164_64 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02462 - - 0.0000000000000000000001254 111.0
HKD2_k127_2426164_65 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins K03528 - - 0.0000000000000000000003758 108.0
HKD2_k127_2426164_66 Type II secretion system (T2SS), protein I - - - 0.000000000000000002088 94.0
HKD2_k127_2426164_67 MTH538 TIR-like domain (DUF1863) - - - 0.00000000000000006381 86.0
HKD2_k127_2426164_68 - - - - 0.00000000000005093 75.0
HKD2_k127_2426164_69 TolA C-terminal K03646 - - 0.0000000000002126 80.0
HKD2_k127_2426164_7 Enoyl-CoA hydratase/isomerase - - - 1.752e-202 651.0
HKD2_k127_2426164_70 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000008126 69.0
HKD2_k127_2426164_71 general secretion pathway protein h K02457 - - 0.00000000003629 72.0
HKD2_k127_2426164_72 cytochrome - - - 0.00000000003634 68.0
HKD2_k127_2426164_74 Type II secretion system (T2SS), protein N K02463 - - 0.0000258 55.0
HKD2_k127_2426164_75 - - - - 0.0006314 45.0
HKD2_k127_2426164_8 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 600.0
HKD2_k127_2426164_9 Sulfate permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 597.0
HKD2_k127_2427637_0 WD40-like Beta Propeller Repeat - - - 0.0 1178.0
HKD2_k127_2427637_1 Oxidoreductase - - - 8.201e-302 933.0
HKD2_k127_2427637_10 PFAM Patatin K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009847 431.0
HKD2_k127_2427637_11 COG0412 Dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 408.0
HKD2_k127_2427637_12 Acyl CoA acetate 3-ketoacid CoA transferase beta subunit K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 397.0
HKD2_k127_2427637_13 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009885 345.0
HKD2_k127_2427637_14 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 328.0
HKD2_k127_2427637_15 Transcriptional regulator K02624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 320.0
HKD2_k127_2427637_16 COG0564 Pseudouridylate synthases, 23S RNA-specific K06175 - 5.4.99.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 306.0
HKD2_k127_2427637_17 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007378 274.0
HKD2_k127_2427637_18 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001131 281.0
HKD2_k127_2427637_19 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.0000000000000000000000000000000000000000000004494 169.0
HKD2_k127_2427637_2 Aldehyde dehydrogenase family K00294 - 1.2.1.88 1.439e-241 756.0
HKD2_k127_2427637_20 proteolysis - - - 0.0000000000000000000000000000000000000000001938 171.0
HKD2_k127_2427637_21 Thioesterase superfamily K07107 - - 0.0000000000000000000000000000000000000001931 156.0
HKD2_k127_2427637_22 DNA-templated transcription, initiation K03088,K03091 - - 0.0000000000000000000000000000000004892 138.0
HKD2_k127_2427637_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 8.968e-237 737.0
HKD2_k127_2427637_4 Glycine cleavage T-protein C-terminal barrel domain - - - 4.464e-215 674.0
HKD2_k127_2427637_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 1.343e-213 671.0
HKD2_k127_2427637_6 Thi4 family - - - 1.597e-198 631.0
HKD2_k127_2427637_7 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006401 557.0
HKD2_k127_2427637_8 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00499,K16319 - 1.14.12.1,1.14.15.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 545.0
HKD2_k127_2427637_9 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 456.0
HKD2_k127_2556865_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.166e-263 824.0
HKD2_k127_2556865_1 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01668 - 4.1.99.2 3.409e-260 811.0
HKD2_k127_2556865_10 amino acid K20265 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004901 366.0
HKD2_k127_2556865_11 Redoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 337.0
HKD2_k127_2556865_12 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 311.0
HKD2_k127_2556865_13 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 317.0
HKD2_k127_2556865_14 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 305.0
HKD2_k127_2556865_15 Belongs to the long-chain O-acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000123 298.0
HKD2_k127_2556865_16 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003874 280.0
HKD2_k127_2556865_17 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003954 261.0
HKD2_k127_2556865_18 Pfam:Pyridox_oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000228 261.0
HKD2_k127_2556865_19 Copper/zinc superoxide dismutase (SODC) K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000005369 256.0
HKD2_k127_2556865_2 AMP-binding enzyme K01897 - 6.2.1.3 2.874e-257 803.0
HKD2_k127_2556865_20 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000004378 244.0
HKD2_k127_2556865_21 Inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.00000000000000000000000000000000000000000000000000000000000003698 229.0
HKD2_k127_2556865_22 Thioesterase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000001129 218.0
HKD2_k127_2556865_23 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000002031 198.0
HKD2_k127_2556865_24 Flavodoxin domain K00230 GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.5.3 0.0000000000000000000000000000000000000000000000000006192 192.0
HKD2_k127_2556865_25 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000001037 192.0
HKD2_k127_2556865_26 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000000000000001081 183.0
HKD2_k127_2556865_27 Protein of unknown function (DUF3187) - - - 0.00000000000000000000000000000000000000000000003348 190.0
HKD2_k127_2556865_28 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000524 163.0
HKD2_k127_2556865_29 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000001208 145.0
HKD2_k127_2556865_3 TonB dependent receptor - - - 5.277e-238 760.0
HKD2_k127_2556865_30 COG2076 Membrane transporters of cations and cationic drugs K03297 - - 0.000000000000000000000000000006047 135.0
HKD2_k127_2556865_31 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000105 134.0
HKD2_k127_2556865_32 - - - - 0.00000000000000001104 93.0
HKD2_k127_2556865_33 6-phosphogluconolactonase activity - - - 0.00000000000000001104 93.0
HKD2_k127_2556865_34 - - - - 0.0000000000005457 83.0
HKD2_k127_2556865_35 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.00000000136 59.0
HKD2_k127_2556865_36 Periplasmic or secreted lipoprotein - - - 0.00006063 54.0
HKD2_k127_2556865_4 Alkyl hydroperoxide reductase K03387 - - 6.277e-234 737.0
HKD2_k127_2556865_5 AMP-binding enzyme - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 2.782e-204 650.0
HKD2_k127_2556865_6 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 464.0
HKD2_k127_2556865_7 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 443.0
HKD2_k127_2556865_8 PFAM Enoyl-CoA hydratase isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003331 410.0
HKD2_k127_2556865_9 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 394.0
HKD2_k127_2559040_0 AMP-binding enzyme C-terminal domain K00666 - - 1.022e-268 848.0
HKD2_k127_2559040_1 Beta-ketoacyl synthase, N-terminal domain - - - 1.956e-213 674.0
HKD2_k127_2559040_10 Glutathione-dependent formaldehyde-activating enzyme K03396 - 4.4.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 306.0
HKD2_k127_2559040_11 transcriptional regulator K07506 - - 0.0000000000000000000000000000000000000000000000000000000000000000008711 239.0
HKD2_k127_2559040_12 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000000001493 136.0
HKD2_k127_2559040_14 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000001305 58.0
HKD2_k127_2559040_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 1.754e-212 667.0
HKD2_k127_2559040_3 Saccharopine dehydrogenase NADP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 605.0
HKD2_k127_2559040_4 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 548.0
HKD2_k127_2559040_5 Belongs to the long-chain O-acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006123 520.0
HKD2_k127_2559040_6 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 514.0
HKD2_k127_2559040_7 Hypothetical methyltransferase K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 346.0
HKD2_k127_2559040_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 346.0
HKD2_k127_2559040_9 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 341.0
HKD2_k127_2568613_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1120.0
HKD2_k127_2568613_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 0.0 1049.0
HKD2_k127_2568613_10 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009411 455.0
HKD2_k127_2568613_11 Dehydrogenase K15054 - 1.1.99.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 407.0
HKD2_k127_2568613_12 PFAM oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006091 370.0
HKD2_k127_2568613_13 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0098772 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 316.0
HKD2_k127_2568613_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001808 276.0
HKD2_k127_2568613_15 hydrogenase 4 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002698 261.0
HKD2_k127_2568613_16 NADH ubiquinone oxidoreductase 20 kDa subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001872 248.0
HKD2_k127_2568613_17 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000001699 214.0
HKD2_k127_2568613_18 gluconolactonase activity K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000001534 180.0
HKD2_k127_2568613_19 Protein of unknown function (DUF1249) K09920 - - 0.00000000000000000000000000000001936 132.0
HKD2_k127_2568613_2 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K06158 - - 4.482e-266 833.0
HKD2_k127_2568613_20 2Fe-2S -binding K07303 - 1.3.99.16 0.000000000000000000000000001101 122.0
HKD2_k127_2568613_21 - - - - 0.000000000000000000006285 93.0
HKD2_k127_2568613_22 PFAM CopG domain protein DNA-binding domain protein - - - 0.00000000000000008374 82.0
HKD2_k127_2568613_23 - - - - 0.000000000002505 74.0
HKD2_k127_2568613_3 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - 1.842e-262 824.0
HKD2_k127_2568613_4 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 7.882e-259 818.0
HKD2_k127_2568613_5 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 3.427e-244 790.0
HKD2_k127_2568613_6 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K12141 - - 1.057e-239 748.0
HKD2_k127_2568613_7 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 585.0
HKD2_k127_2568613_8 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007965 541.0
HKD2_k127_2568613_9 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 497.0
HKD2_k127_2607406_0 Sodium:dicarboxylate symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 602.0
HKD2_k127_2607406_1 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000001561 140.0
HKD2_k127_2607406_2 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000001972 93.0
HKD2_k127_2608981_0 Alpha-tubulin suppressor and related RCC1 domain-containing - - - 0.0000000000000000000000000000000000000000000000000000000000000002509 242.0
HKD2_k127_2608981_1 PKD domain containing protein - - - 0.00000000000000001911 96.0
HKD2_k127_2619868_0 FAD dependent oxidoreductase K07077 - - 7.485e-216 692.0
HKD2_k127_2619868_1 Thioesterase K07107 - - 0.0000000000000000000000000003534 123.0
HKD2_k127_2631095_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.089e-246 773.0
HKD2_k127_2631095_1 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 3.063e-246 770.0
HKD2_k127_2631095_2 mechanosensitive ion channel K03442,K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006015 422.0
HKD2_k127_2631095_3 cytochrome c oxidase (Subunit II) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004874 253.0
HKD2_k127_2631095_4 - - - - 0.0000000000001476 73.0
HKD2_k127_2680148_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 6.168e-310 963.0
HKD2_k127_2680148_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 4.62e-307 965.0
HKD2_k127_2680148_10 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 468.0
HKD2_k127_2680148_11 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 422.0
HKD2_k127_2680148_12 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 392.0
HKD2_k127_2680148_13 D-alanyl-D-alanine carboxypeptidase K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 368.0
HKD2_k127_2680148_14 Chromate transporter K07240 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 359.0
HKD2_k127_2680148_15 von Willebrand factor (VWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 331.0
HKD2_k127_2680148_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 329.0
HKD2_k127_2680148_17 Secreted protein, containing von Willebrand factor (VWF) type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 338.0
HKD2_k127_2680148_18 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 324.0
HKD2_k127_2680148_19 COG0811 Biopolymer transport proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 297.0
HKD2_k127_2680148_2 Acetolactate synthase K01652 - 2.2.1.6 7.176e-296 918.0
HKD2_k127_2680148_20 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003552 297.0
HKD2_k127_2680148_21 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000117 273.0
HKD2_k127_2680148_22 Glutathione S-transferase, C-terminal domain K00799,K11209 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000002681 252.0
HKD2_k127_2680148_23 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000000000000000000000000000000000000000000000003133 230.0
HKD2_k127_2680148_24 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000003529 208.0
HKD2_k127_2680148_25 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000005596 215.0
HKD2_k127_2680148_26 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000000000000006358 189.0
HKD2_k127_2680148_27 PFAM histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000000000000000168 184.0
HKD2_k127_2680148_28 - - - - 0.00000000000000000000000000000000000000000000004741 180.0
HKD2_k127_2680148_29 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000001138 175.0
HKD2_k127_2680148_3 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 1.707e-227 714.0
HKD2_k127_2680148_30 - - - - 0.0000000000000000000000000000000000000000004271 175.0
HKD2_k127_2680148_31 AMMECR1 - - - 0.000000000000000000000000000000000000000008712 162.0
HKD2_k127_2680148_32 TIGRFAM Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000002689 161.0
HKD2_k127_2680148_33 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.0000000000000000000000000000000000002383 150.0
HKD2_k127_2680148_34 Protein tyrosine kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000001089 144.0
HKD2_k127_2680148_35 Alpha beta hydrolase - - - 0.0000000000000000000000000001845 124.0
HKD2_k127_2680148_36 - - - - 0.0000000000000002545 83.0
HKD2_k127_2680148_37 - - - - 0.00000000000007598 85.0
HKD2_k127_2680148_38 Glutathione S-transferase, C-terminal domain - - - 0.0000000000001748 84.0
HKD2_k127_2680148_39 - - - - 0.000000000000581 78.0
HKD2_k127_2680148_4 Bacterial protein of unknown function (DUF885) - - - 2.363e-218 695.0
HKD2_k127_2680148_40 - - - - 0.000000000001126 80.0
HKD2_k127_2680148_5 Pyruvate formate lyase-activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 595.0
HKD2_k127_2680148_6 alcohol dehydrogenase K00001,K00055 - 1.1.1.1,1.1.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 502.0
HKD2_k127_2680148_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 491.0
HKD2_k127_2680148_8 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 504.0
HKD2_k127_2680148_9 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006881 485.0
HKD2_k127_2757579_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.797e-250 776.0
HKD2_k127_2757579_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000000000000000000000000000128 171.0
HKD2_k127_2757579_2 - - - - 0.0000000815 54.0
HKD2_k127_2759872_0 heavy metal translocating P-type ATPase K01534 - 3.6.3.3,3.6.3.5 0.0 1023.0
HKD2_k127_2759872_1 permease K07243 - - 5.877e-235 743.0
HKD2_k127_2759872_2 PFAM multicopper oxidase type K08100 - 1.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 466.0
HKD2_k127_2759872_3 Type IV secretory pathway VirD4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005664 390.0
HKD2_k127_2759872_4 Nodulation protein S (NodS) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 307.0
HKD2_k127_2759872_5 transcriptional - - - 0.0000000000000000000000000000000000000000000000000001301 188.0
HKD2_k127_2759872_6 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000000000841 154.0
HKD2_k127_2759872_8 - - - - 0.000008398 58.0
HKD2_k127_2773712_0 FAD dependent oxidoreductase central domain - - - 1.163e-301 951.0
HKD2_k127_2773712_1 ATPases associated with a variety of cellular activities K05847 GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006111 412.0
HKD2_k127_2773712_2 PFAM Substrate-binding region of ABC-type glycine betaine transport system K05845 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0033554,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0104004 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 347.0
HKD2_k127_2773712_3 Binding-protein-dependent transport system inner membrane component K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000104 186.0
HKD2_k127_2773712_4 Platelet-activating factor acetylhydrolase, isoform II - - - 0.000000000005079 68.0
HKD2_k127_2780683_0 PFAM Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 418.0
HKD2_k127_2780683_1 Protein of unknown function (DUF504) - - - 0.000000000000000000000002778 106.0
HKD2_k127_2780683_2 receptor K02014 - - 0.00004577 51.0
HKD2_k127_2788304_0 electron transfer activity - - - 0.000000000000000000000000000000000000000000000000000005289 192.0
HKD2_k127_2788304_1 - - - - 0.00000000000000000000000000000000000000000000000003793 190.0
HKD2_k127_2788304_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000001748 124.0
HKD2_k127_2796831_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K13614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 601.0
HKD2_k127_2796831_1 PFAM Cytochrome P450 K14338 - 1.14.14.1,1.6.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 396.0
HKD2_k127_2796831_2 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000001135 171.0
HKD2_k127_2796831_3 belongs to the Fur family K09826 - - 0.000000000000000000000000000000000007174 140.0
HKD2_k127_2796831_4 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000008625 147.0
HKD2_k127_2796831_5 Domain of unknown function (DUF374) - - - 0.0000000000000000000000000000000002025 136.0
HKD2_k127_2796831_6 Type II transport protein GspH K08084 - - 0.00000000000000000000004913 107.0
HKD2_k127_2796831_7 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.00000007899 66.0
HKD2_k127_2843192_0 2-methylcitrate dehydratase K01720 - 4.2.1.79 9.085e-213 670.0
HKD2_k127_2843192_1 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 345.0
HKD2_k127_2843192_2 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 324.0
HKD2_k127_2843192_3 AcnD-accessory protein PrpF K09788 - - 0.00000000000000000000000000000000000000000000000000000000000000006986 223.0
HKD2_k127_2843192_4 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000000000008494 191.0
HKD2_k127_2843192_5 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000004052 134.0
HKD2_k127_2843192_6 Lipid A 3-O-deacylase (PagL) - - - 0.00000000000121 81.0
HKD2_k127_2849306_0 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 538.0
HKD2_k127_2849306_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004934 479.0
HKD2_k127_2849306_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000003748 92.0
HKD2_k127_2849306_3 - - - - 0.00001508 51.0
HKD2_k127_2851193_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 459.0
HKD2_k127_2851193_1 NADH dehydrogenase (ubiquinone) flavoprotein 2 K03943 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0007275,GO:0007399,GO:0007507,GO:0008137,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009888,GO:0009987,GO:0010257,GO:0014706,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0042773,GO:0042775,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0048513,GO:0048731,GO:0048738,GO:0048856,GO:0050136,GO:0055086,GO:0055114,GO:0060537,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072359,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000005307 164.0
HKD2_k127_2851193_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000005419 54.0
HKD2_k127_2851193_3 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271,K12961 - 5.3.1.28 0.00000419 49.0
HKD2_k127_285562_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 3.374e-242 767.0
HKD2_k127_285562_1 Bacterial protein of unknown function (DUF885) - - - 9.832e-222 702.0
HKD2_k127_285562_2 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008995 491.0
HKD2_k127_285562_3 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01585 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009548 479.0
HKD2_k127_285562_4 Protein of unknown function (DUF1838) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007973 337.0
HKD2_k127_285562_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009898 246.0
HKD2_k127_285562_6 Protein of unknown function (DUF1134) - - - 0.00000000000000000000000000000000000000000000000000000000002799 213.0
HKD2_k127_285562_7 PFAM RNP-1 like RNA-binding protein - - - 0.0000000000000000000000000000001593 128.0
HKD2_k127_285562_8 PFAM RNP-1 like RNA-binding protein - - - 0.00000000000000000000000004454 109.0
HKD2_k127_285562_9 membrane - - - 0.000000000000000000000001732 105.0
HKD2_k127_2861086_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 1.683e-288 904.0
HKD2_k127_2861086_1 AAA ATPase, central domain protein K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 580.0
HKD2_k127_2861086_10 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000004672 134.0
HKD2_k127_2861086_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004563 567.0
HKD2_k127_2861086_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 497.0
HKD2_k127_2861086_4 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 362.0
HKD2_k127_2861086_5 Belongs to the ClpA ClpB family K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001668 281.0
HKD2_k127_2861086_6 methyltransferase activity K21310 - 2.1.1.334 0.00000000000000000000000000000000000000000000000000000000000000000000000000002208 269.0
HKD2_k127_2861086_7 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000001276 272.0
HKD2_k127_2861086_8 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000000000000000000000000000000000000001351 179.0
HKD2_k127_2868325_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 6.594e-228 712.0
HKD2_k127_2868325_1 Glutathione S-transferase K03599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 373.0
HKD2_k127_2868325_2 Cytochrome C1 K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001866 271.0
HKD2_k127_2868325_3 Stringent starvation protein B K03600 - - 0.00000000000000000000000000000000000000000000003856 174.0
HKD2_k127_2868325_4 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000004098 140.0
HKD2_k127_2868325_5 TniQ - - - 0.0000000000000000000000000000001242 139.0
HKD2_k127_2924593_0 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005528 392.0
HKD2_k127_2924593_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000003362 233.0
HKD2_k127_2924593_2 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000002961 74.0
HKD2_k127_2946724_1 Polymer-forming cytoskeletal - - - 0.00000000000000009053 87.0
HKD2_k127_2946724_2 Polymer-forming cytoskeletal - - - 0.0000000000000001961 89.0
HKD2_k127_2993308_0 Major facilitator superfamily K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 520.0
HKD2_k127_2993308_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 492.0
HKD2_k127_2993308_10 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000001071 128.0
HKD2_k127_2993308_11 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000002371 107.0
HKD2_k127_2993308_12 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000386 115.0
HKD2_k127_2993308_13 there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc K02913 - - 0.00000000000000000007511 89.0
HKD2_k127_2993308_14 - - - - 0.0000000000000000003095 93.0
HKD2_k127_2993308_15 Dehydrogenase K07077 - - 0.00000000000003699 72.0
HKD2_k127_2993308_2 Exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 427.0
HKD2_k127_2993308_3 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 342.0
HKD2_k127_2993308_4 Belongs to the UPF0758 family K03630 GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 298.0
HKD2_k127_2993308_5 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006436 280.0
HKD2_k127_2993308_6 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002267 286.0
HKD2_k127_2993308_7 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000006041 247.0
HKD2_k127_2993308_8 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000001797 214.0
HKD2_k127_2993308_9 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000008626 176.0
HKD2_k127_3033389_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 589.0
HKD2_k127_3033389_1 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 330.0
HKD2_k127_3083536_0 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 312.0
HKD2_k127_3083536_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000000000000000000000009432 144.0
HKD2_k127_3083536_2 Carbohydrate family 9 binding domain-like - - - 0.0000000002899 61.0
HKD2_k127_314488_0 aconitate hydratase K01681,K20455 - 4.2.1.117,4.2.1.3 0.0 1561.0
HKD2_k127_314488_1 AcnD-accessory protein PrpF K09788 - - 4.983e-223 695.0
HKD2_k127_314488_2 Belongs to the citrate synthase family K01659 - 2.3.3.5 1.301e-215 672.0
HKD2_k127_314488_3 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 443.0
HKD2_k127_314488_4 2-methylcitrate dehydratase K01720 - 4.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 308.0
HKD2_k127_314488_5 Cupin domain - - - 0.0000000000000000000000000000002912 126.0
HKD2_k127_3214178_0 Belongs to the GcvT family K00315,K19191 - 1.5.3.19,1.5.8.4 0.0 1442.0
HKD2_k127_3214178_1 Glycine cleavage T-protein C-terminal barrel domain K00302 - 1.5.3.1 0.0 1343.0
HKD2_k127_3214178_2 Belongs to the GcvT family K00315,K19191 - 1.5.3.19,1.5.8.4 0.0 1161.0
HKD2_k127_3214178_3 Belongs to the GcvT family K00315 - 1.5.8.4 0.0 1068.0
HKD2_k127_3214178_4 sarcosine oxidase, beta subunit K00303 - 1.5.3.1 9.805e-229 719.0
HKD2_k127_3214178_5 PFAM helix-turn-helix- domain containing protein, AraC type K21826 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 404.0
HKD2_k127_3214178_6 FAD dependent oxidoreductase central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005118 229.0
HKD2_k127_3214178_7 Sarcosine oxidase, gamma subunit family K00305 - 1.5.3.1 0.00000000000000000000000000000000000000001105 160.0
HKD2_k127_3214178_8 Sarcosine oxidase, delta subunit family K00304 - 1.5.3.1 0.0000000000000000000000000000000000000001263 151.0
HKD2_k127_3214365_0 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008434 279.0
HKD2_k127_3214365_1 diguanylate cyclase K13069 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000002768 238.0
HKD2_k127_3214365_2 transporter K03305,K06218 - - 0.00000000000000000000000005679 108.0
HKD2_k127_3217093_0 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 7.531e-245 782.0
HKD2_k127_3217093_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 591.0
HKD2_k127_3217093_10 PFAM MaoC like domain - - - 0.000000000000000000000000000000000000000000000002047 178.0
HKD2_k127_3217093_11 synthesis repressor, PhaR - - - 0.00000000000000000000000000000000000007277 152.0
HKD2_k127_3217093_12 PadR family transcriptional regulator K10947 - - 0.000000000000000000000000000000000001431 142.0
HKD2_k127_3217093_13 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000004549 113.0
HKD2_k127_3217093_14 Water Stress and Hypersensitive response - - - 0.0000000000000000000008886 102.0
HKD2_k127_3217093_15 Belongs to the ompA family K03286 - - 0.00000000000001422 84.0
HKD2_k127_3217093_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 483.0
HKD2_k127_3217093_3 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009434 474.0
HKD2_k127_3217093_4 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 462.0
HKD2_k127_3217093_5 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 400.0
HKD2_k127_3217093_6 Putative sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 323.0
HKD2_k127_3217093_7 Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K00567,K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000001486 273.0
HKD2_k127_3217093_8 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000009104 222.0
HKD2_k127_3217093_9 Virulence protein - - - 0.00000000000000000000000000000000000000000000000000000000475 214.0
HKD2_k127_328769_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 1.48e-294 921.0
HKD2_k127_328769_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 6.258e-279 865.0
HKD2_k127_328769_10 oxidase, assembly K02258 - - 0.0000000000000000000000000000000002277 139.0
HKD2_k127_328769_11 Protein of unknown function (DUF2909) - - - 0.00000000001913 69.0
HKD2_k127_328769_12 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 - 2.4.1.129,3.4.16.4 0.0000000001459 64.0
HKD2_k127_328769_13 VanZ like family - - - 0.00000001577 66.0
HKD2_k127_328769_2 Bacterial protein of unknown function (DUF885) - - - 9.402e-215 682.0
HKD2_k127_328769_3 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 1.18e-196 625.0
HKD2_k127_328769_4 PFAM TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006483 551.0
HKD2_k127_328769_5 Heme copper-type cytochrome quinol oxidase subunit 3 K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 415.0
HKD2_k127_328769_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 370.0
HKD2_k127_328769_7 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 338.0
HKD2_k127_328769_8 SURF1-like protein - - - 0.00000000000000000000000000000000000000001388 162.0
HKD2_k127_328769_9 signal sequence binding - - - 0.0000000000000000000000000000000000001444 153.0
HKD2_k127_328770_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 8.504e-231 732.0
HKD2_k127_328770_1 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 - 2.4.1.129,3.4.16.4 3.065e-222 711.0
HKD2_k127_328770_2 COG3104 Dipeptide tripeptide permease K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007508 617.0
HKD2_k127_328770_3 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 528.0
HKD2_k127_328770_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001725 286.0
HKD2_k127_328770_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000001364 233.0
HKD2_k127_328770_6 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000000009131 192.0
HKD2_k127_328770_7 Tetratricopeptide repeat - - - 0.00000000000000001691 90.0
HKD2_k127_328770_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000002154 70.0
HKD2_k127_328770_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000004075 66.0
HKD2_k127_3295585_0 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 9.516e-295 918.0
HKD2_k127_3295585_1 Dehydrogenase K17760 - 1.1.9.1 1.166e-257 825.0
HKD2_k127_3295585_10 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005034 249.0
HKD2_k127_3295585_11 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000005235 227.0
HKD2_k127_3295585_12 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000000000000003705 210.0
HKD2_k127_3295585_13 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000009785 204.0
HKD2_k127_3295585_14 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.000000000000000000000000000000000000000000000000000004362 202.0
HKD2_k127_3295585_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000001477 188.0
HKD2_k127_3295585_16 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.000002841 50.0
HKD2_k127_3295585_2 PQQ-like domain K22473 - 1.1.5.5 4.652e-244 775.0
HKD2_k127_3295585_3 Belongs to the GMC oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 595.0
HKD2_k127_3295585_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006937 490.0
HKD2_k127_3295585_5 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 445.0
HKD2_k127_3295585_6 Sugar (and other) transporter K08195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000926 436.0
HKD2_k127_3295585_7 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 376.0
HKD2_k127_3295585_8 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 334.0
HKD2_k127_3295585_9 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 326.0
HKD2_k127_3358265_0 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 5.071e-237 750.0
HKD2_k127_3358265_1 protein conserved in bacteria - - - 8.631e-210 669.0
HKD2_k127_3358265_10 YceI-like domain - - - 0.00000000000000000000000000000000000001545 158.0
HKD2_k127_3358265_11 YceI-like domain - - - 0.000000000000000000000000000002961 129.0
HKD2_k127_3358265_12 Protein of unknown function (DUF2845) - - - 0.00000000001101 72.0
HKD2_k127_3358265_13 Protein of unknown function (DUF2845) - - - 0.00000000005752 71.0
HKD2_k127_3358265_14 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000001313 57.0
HKD2_k127_3358265_15 - - - - 0.0000003382 61.0
HKD2_k127_3358265_2 Bacterial extracellular solute-binding protein K02055 GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576 - 5.495e-201 636.0
HKD2_k127_3358265_3 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 591.0
HKD2_k127_3358265_4 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 447.0
HKD2_k127_3358265_5 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 436.0
HKD2_k127_3358265_6 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000002585 246.0
HKD2_k127_3358265_7 Sugar (and other) transporter K07552 - - 0.0000000000000000000000000000000000000000000000000003614 203.0
HKD2_k127_3358265_8 PFAM peptidase T2 asparaginase 2 K13051 - 3.4.19.5 0.000000000000000000000000000000000000000000002194 168.0
HKD2_k127_3358265_9 Cytochrome K12262 - - 0.00000000000000000000000000000000000000004125 161.0
HKD2_k127_3371812_0 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 1.022e-306 949.0
HKD2_k127_3371812_1 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 1.844e-217 686.0
HKD2_k127_3371812_2 TonB dependent receptor - - - 2.622e-212 690.0
HKD2_k127_3371812_3 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 354.0
HKD2_k127_3371812_4 Dehydrogenase E1 component K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 306.0
HKD2_k127_3371812_5 acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000004824 229.0
HKD2_k127_3371812_6 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000008262 167.0
HKD2_k127_3371812_7 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000002759 95.0
HKD2_k127_33723_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K15022 - 1.17.1.10 4.333e-285 885.0
HKD2_k127_33723_1 Short chain dehydrogenase - - - 9.995e-263 824.0
HKD2_k127_33723_10 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002472 274.0
HKD2_k127_33723_11 COG2755 Lysophospholipase L1 and related esterases K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000002342 237.0
HKD2_k127_33723_12 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000001593 203.0
HKD2_k127_33723_13 acetyltransferase - - - 0.00000000000000000000000000000000000000000001323 184.0
HKD2_k127_33723_14 lipid kinase, YegS Rv2252 BmrU family - - - 0.00000000000000000000000000000000000000000001359 177.0
HKD2_k127_33723_15 - - - - 0.000000000000000000000000000000000000000001487 166.0
HKD2_k127_33723_16 Poly(hydroxyalcanoate) granule associated protein - - - 0.00000000000000001323 90.0
HKD2_k127_33723_17 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 0.00000000000000001791 81.0
HKD2_k127_33723_2 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 5.092e-261 832.0
HKD2_k127_33723_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 2.337e-238 749.0
HKD2_k127_33723_4 FtsX-like permease family K02004 - - 1.645e-216 708.0
HKD2_k127_33723_5 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 477.0
HKD2_k127_33723_6 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 433.0
HKD2_k127_33723_7 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004241 381.0
HKD2_k127_33723_8 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008033 299.0
HKD2_k127_33723_9 PFAM transferase hexapeptide repeat containing protein K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 299.0
HKD2_k127_339933_0 Vitamin B12 dependent methionine synthase, activation K00548 - 2.1.1.13 0.0 1010.0
HKD2_k127_339933_1 Peptidase m28 K01269 - - 3.978e-238 747.0
HKD2_k127_339933_10 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000004673 261.0
HKD2_k127_339933_11 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000005919 255.0
HKD2_k127_339933_12 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000001568 230.0
HKD2_k127_339933_13 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000002242 221.0
HKD2_k127_339933_14 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000007412 206.0
HKD2_k127_339933_15 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564 - 0.0000000000000000000001906 106.0
HKD2_k127_339933_2 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 532.0
HKD2_k127_339933_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 482.0
HKD2_k127_339933_4 PCRF K02835 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 480.0
HKD2_k127_339933_5 Flavoprotein involved in K transport K03379 - 1.14.13.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 485.0
HKD2_k127_339933_6 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 420.0
HKD2_k127_339933_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007444 409.0
HKD2_k127_339933_8 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 341.0
HKD2_k127_339933_9 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000000000000000608 271.0
HKD2_k127_3423741_0 COG3209 Rhs family protein - - - 6.515e-195 631.0
HKD2_k127_3423741_1 Phenylalanine-4-hydroxylase K00500 - 1.14.16.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 487.0
HKD2_k127_3423741_10 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000001718 132.0
HKD2_k127_3423741_11 ABC-type molybdate transport system periplasmic component K02020 GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015689,GO:0015698,GO:0030973,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:1901359 - 0.00000000000000000000001291 104.0
HKD2_k127_3423741_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 473.0
HKD2_k127_3423741_3 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 375.0
HKD2_k127_3423741_4 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 314.0
HKD2_k127_3423741_5 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 287.0
HKD2_k127_3423741_6 Cellulose biosynthesis protein BcsQ - - - 0.0000000000000000000000000000000000000000000000000000000000000004163 229.0
HKD2_k127_3423741_7 Beta-lactamase class C - - - 0.0000000000000000000000000000000000000000299 170.0
HKD2_k127_3423741_8 PFAM Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000002444 151.0
HKD2_k127_3423741_9 - - - - 0.000000000000000000000000000000000802 136.0
HKD2_k127_378050_0 belongs to the aldehyde dehydrogenase family K00128,K19700 - 1.2.1.3,1.2.1.83 3.726e-194 616.0
HKD2_k127_378050_1 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 598.0
HKD2_k127_378050_2 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 452.0
HKD2_k127_378050_3 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 444.0
HKD2_k127_378050_4 Possible lysine decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 291.0
HKD2_k127_378050_5 Predicted periplasmic protein (DUF2092) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009883 248.0
HKD2_k127_378050_6 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000000000001207 132.0
HKD2_k127_378050_7 - - - - 0.0000000000000000000001199 105.0
HKD2_k127_378050_8 Bile acid K03453 - - 0.0000000000000006732 85.0
HKD2_k127_3839376_0 Nitrite reductase K15864 - 1.7.2.1,1.7.99.1 8.401e-314 976.0
HKD2_k127_3839376_1 protein involved in response to NO K07234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001193 263.0
HKD2_k127_3839376_2 COG1024 Enoyl-CoA hydratase carnithine racemase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000009299 222.0
HKD2_k127_3839376_3 PFAM Cyclic nucleotide-binding K21563 - - 0.0000000000000000000000000000000000000000004418 166.0
HKD2_k127_3839376_4 Cupin superfamily (DUF985) K09705 - - 0.00000000000000000000000000000000009023 144.0
HKD2_k127_3839376_5 Invasion gene expression up-regulator, SirB - - - 0.0000000000000000000000000000007475 127.0
HKD2_k127_3839376_6 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000002479 113.0
HKD2_k127_3852570_0 Exporters of the RND superfamily K07003 - - 0.0 1082.0
HKD2_k127_3852570_1 peptidase K01354 - 3.4.21.83 1.392e-276 867.0
HKD2_k127_3852570_10 translation initiation factor activity K06996 - - 0.000000000000000000000000000000000002966 146.0
HKD2_k127_3852570_11 - - - - 0.00000000000000006591 93.0
HKD2_k127_3852570_2 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 603.0
HKD2_k127_3852570_3 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 436.0
HKD2_k127_3852570_4 Glutathione S-transferase, C-terminal domain K00799,K11209 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007656 356.0
HKD2_k127_3852570_5 COG0501 Zn-dependent protease with chaperone function - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 331.0
HKD2_k127_3852570_6 DSBA-like thioredoxin domain K14584 - 5.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008553 310.0
HKD2_k127_3852570_7 Protein of unknown function (DUF1329) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 299.0
HKD2_k127_3852570_8 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008251 302.0
HKD2_k127_3866600_0 receptor K16087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 500.0
HKD2_k127_3866600_1 COG2010 Cytochrome c, mono- and diheme variants K15864 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1,1.7.99.1 0.00000000000006282 71.0
HKD2_k127_387802_0 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000001689 184.0
HKD2_k127_387802_1 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.0000000000000000000000000000000000000002617 162.0
HKD2_k127_3897600_0 Fructose-bisphosphate aldolase class-I K01623 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001439 275.0
HKD2_k127_3897600_1 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000284 246.0
HKD2_k127_3897600_2 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000002654 211.0
HKD2_k127_3897600_3 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000001036 134.0
HKD2_k127_3897600_4 - - - - 0.000000000000000000000001625 115.0
HKD2_k127_3898226_0 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 0.0 1042.0
HKD2_k127_3898226_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 2.289e-286 895.0
HKD2_k127_3898226_10 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 314.0
HKD2_k127_3898226_11 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005406 314.0
HKD2_k127_3898226_12 Flavin containing amine oxidoreductase K06955 - - 0.00000000000000000000000000000000000000000000000000000000000000000004799 246.0
HKD2_k127_3898226_13 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000007533 230.0
HKD2_k127_3898226_14 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions K02553 - - 0.00000000000000000000000000000000000000000000000000000000001451 213.0
HKD2_k127_3898226_15 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 0.00000000000000000000000000000000000000000001483 174.0
HKD2_k127_3898226_16 Putative adhesin - - - 0.00000000000000000000000000000000000000001695 170.0
HKD2_k127_3898226_17 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000003183 151.0
HKD2_k127_3898226_18 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000002087 151.0
HKD2_k127_3898226_19 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000000000001647 138.0
HKD2_k127_3898226_2 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 4.076e-230 726.0
HKD2_k127_3898226_20 membrane - - - 0.000000000000000000000000003972 118.0
HKD2_k127_3898226_21 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.00000000000000000268 90.0
HKD2_k127_3898226_22 - - - - 0.0000000262 63.0
HKD2_k127_3898226_3 Glycine cleavage T-protein C-terminal barrel domain - - - 1.084e-223 698.0
HKD2_k127_3898226_4 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004923 619.0
HKD2_k127_3898226_5 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 571.0
HKD2_k127_3898226_6 TIGRFAM A G-specific adenine glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 386.0
HKD2_k127_3898226_7 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 376.0
HKD2_k127_3898226_8 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 338.0
HKD2_k127_3898226_9 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 331.0
HKD2_k127_3907835_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531,K12955 - 3.6.3.2 0.0 1097.0
HKD2_k127_3907835_1 PFAM Malic enzyme, NAD binding domain K00029 - 1.1.1.40 2.208e-273 852.0
HKD2_k127_3907835_10 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 535.0
HKD2_k127_3907835_11 mannitol 2-dehydrogenase activity K11690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 518.0
HKD2_k127_3907835_12 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 477.0
HKD2_k127_3907835_13 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 466.0
HKD2_k127_3907835_14 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K04127,K11325,K21174 - 5.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 468.0
HKD2_k127_3907835_15 beta-keto acid cleavage enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 471.0
HKD2_k127_3907835_16 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004001 465.0
HKD2_k127_3907835_17 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 441.0
HKD2_k127_3907835_18 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003236 411.0
HKD2_k127_3907835_19 Multidrug resistance efflux pump - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 417.0
HKD2_k127_3907835_2 Carboxyl transferase domain K13778 - 6.4.1.5 3.411e-253 805.0
HKD2_k127_3907835_20 Enoyl-(Acyl carrier protein) reductase K13774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 406.0
HKD2_k127_3907835_21 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 401.0
HKD2_k127_3907835_22 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007198 408.0
HKD2_k127_3907835_23 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 392.0
HKD2_k127_3907835_24 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 381.0
HKD2_k127_3907835_25 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 333.0
HKD2_k127_3907835_26 histidine kinase HAMP region domain protein K07645 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 336.0
HKD2_k127_3907835_27 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 332.0
HKD2_k127_3907835_28 Transcriptional regulator K07666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 293.0
HKD2_k127_3907835_29 Biotin-lipoyl like K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 292.0
HKD2_k127_3907835_3 Biotin carboxylase C-terminal domain K01968,K13777 - 6.4.1.4,6.4.1.5 1.463e-245 779.0
HKD2_k127_3907835_30 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003625 273.0
HKD2_k127_3907835_31 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004976 269.0
HKD2_k127_3907835_32 Arylsulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002778 255.0
HKD2_k127_3907835_33 Enoyl-CoA hydratase/isomerase K13779 - 4.2.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000007083 246.0
HKD2_k127_3907835_34 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000007086 235.0
HKD2_k127_3907835_35 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000289 242.0
HKD2_k127_3907835_36 Protein of unknown function (DUF1302) - - - 0.00000000000000000000000000000000000000000000000000000000000000001216 238.0
HKD2_k127_3907835_37 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity - - - 0.00000000000000000000000000000000000000000000000000000000000000008242 229.0
HKD2_k127_3907835_38 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000001255 228.0
HKD2_k127_3907835_39 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000002348 223.0
HKD2_k127_3907835_4 major facilitator superfamily K03446 - - 1.956e-223 702.0
HKD2_k127_3907835_40 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000001068 222.0
HKD2_k127_3907835_41 Transcriptional regulator K18900 - - 0.00000000000000000000000000000000000000000000000000000000000001163 227.0
HKD2_k127_3907835_42 Peptidase_C39 like family - - - 0.0000000000000000000000000000000000000000000000000000000000004272 225.0
HKD2_k127_3907835_43 lipocalin K03098 - - 0.000000000000000000000000000000000000000000000000000001306 199.0
HKD2_k127_3907835_44 - - - - 0.000000000000000000000000000000000000000000000000000007962 198.0
HKD2_k127_3907835_45 Domain of unknown function (DUF4396) - - - 0.000000000000000000000000000000000000000000000000003751 186.0
HKD2_k127_3907835_46 Rhodanese domain protein - - - 0.000000000000000000000000000000000000000000008387 167.0
HKD2_k127_3907835_47 membrane K15977 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000218 160.0
HKD2_k127_3907835_48 Allene oxide cyclase - - - 0.0000000000000000000000000000000000000002259 154.0
HKD2_k127_3907835_49 Rubrerythrin - - - 0.0000000000000000000000000000000000003493 158.0
HKD2_k127_3907835_5 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 5.298e-206 659.0
HKD2_k127_3907835_50 Domain of unknown function (DUF1924) - - - 0.00000000000000000000000000000000032 135.0
HKD2_k127_3907835_51 helix_turn_helix, mercury resistance K08365 - - 0.0000000000000000000000000000000005713 136.0
HKD2_k127_3907835_52 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000004377 125.0
HKD2_k127_3907835_53 transcriptional regulator K03712 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0044212,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071236,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000005616 132.0
HKD2_k127_3907835_54 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000000000000000001505 121.0
HKD2_k127_3907835_55 PFAM Di-haem cytochrome c - - - 0.000000000000000000000000001079 124.0
HKD2_k127_3907835_57 - - - - 0.000009714 56.0
HKD2_k127_3907835_6 acyl-CoA dehydrogenase K11731 - - 5.775e-194 610.0
HKD2_k127_3907835_7 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 617.0
HKD2_k127_3907835_8 PFAM Pyridoxal-dependent decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 567.0
HKD2_k127_3907835_9 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 529.0
HKD2_k127_3929828_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 535.0
HKD2_k127_3929828_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.0000000000000000000000000001487 124.0
HKD2_k127_3929828_2 COG2801 Transposase and inactivated derivatives K07497 - - 0.0001812 47.0
HKD2_k127_3933675_0 SPTR Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000001625 136.0
HKD2_k127_3933675_1 SnoaL-like domain - - - 0.0002045 45.0
HKD2_k127_3933675_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0005137 51.0
HKD2_k127_3954282_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008498 514.0
HKD2_k127_3954282_1 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 497.0
HKD2_k127_3954282_10 helix_turn_helix, Lux Regulon K03556 - - 0.000003583 49.0
HKD2_k127_3954282_2 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007992 451.0
HKD2_k127_3954282_3 Cell wall hydrolase autolysin K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008135 340.0
HKD2_k127_3954282_4 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 333.0
HKD2_k127_3954282_5 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 307.0
HKD2_k127_3954282_6 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006293 259.0
HKD2_k127_3954282_7 FAD binding domain K03391,K05712 - 1.14.13.127,1.14.13.50 0.0000000000000000000000000000000000000000000000109 181.0
HKD2_k127_3954282_8 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.000000000000000000000000000000000000005238 156.0
HKD2_k127_3954282_9 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000000000002907 136.0
HKD2_k127_3991012_0 glutamate synthase K00284 - 1.4.7.1 0.0 2517.0
HKD2_k127_3991012_1 TIGRFAM glutamate synthase, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 3.743e-238 805.0
HKD2_k127_3991012_10 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 328.0
HKD2_k127_3991012_11 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006958 346.0
HKD2_k127_3991012_12 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000789 319.0
HKD2_k127_3991012_13 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 316.0
HKD2_k127_3991012_14 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 297.0
HKD2_k127_3991012_15 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase K01802,K03772,K03773 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000001028 203.0
HKD2_k127_3991012_16 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000000000000000000000000007825 191.0
HKD2_k127_3991012_17 Auxin binding protein - - - 0.0000000000000000000000000000000000000000000000005719 178.0
HKD2_k127_3991012_18 Sh3 type 3 domain protein K01361 - 3.4.21.96 0.0000000000000000000000000000000000000001032 162.0
HKD2_k127_3991012_19 Uncharacterized ACR, COG1993 - - - 0.00000000000000000000000000000000000002966 152.0
HKD2_k127_3991012_2 Carboxyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 601.0
HKD2_k127_3991012_20 Methyltransferase domain - - - 0.0000000000000000000000000000003018 136.0
HKD2_k127_3991012_22 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000003456 118.0
HKD2_k127_3991012_23 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000008148 118.0
HKD2_k127_3991012_24 - - - - 0.000000000000000000001301 101.0
HKD2_k127_3991012_25 SnoaL-like domain - - - 0.000000000000000001267 89.0
HKD2_k127_3991012_26 - - - - 0.000000000000000004031 88.0
HKD2_k127_3991012_27 Diacylglycerol kinase K19302 - 3.6.1.27 0.0000000000001401 84.0
HKD2_k127_3991012_28 PFAM peptidase M61 - - - 0.00000000001113 70.0
HKD2_k127_3991012_29 Peptidase, M61 - - - 0.00000003653 58.0
HKD2_k127_3991012_3 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 577.0
HKD2_k127_3991012_4 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 547.0
HKD2_k127_3991012_5 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 425.0
HKD2_k127_3991012_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009026 401.0
HKD2_k127_3991012_7 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 361.0
HKD2_k127_3991012_8 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 355.0
HKD2_k127_3991012_9 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 356.0
HKD2_k127_4047811_0 COG2217 Cation transport ATPase K01533 - 3.6.3.4 2.302e-232 744.0
HKD2_k127_4047811_1 TIGRFAM cytochrome c oxidase accessory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005045 586.0
HKD2_k127_4047811_2 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006367 384.0
HKD2_k127_4047811_3 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 342.0
HKD2_k127_4047811_4 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 317.0
HKD2_k127_4047811_5 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000000000000000000000000000001399 127.0
HKD2_k127_4047811_6 Cytochrome oxidase maturation protein - - - 0.0000000000004198 72.0
HKD2_k127_4047811_7 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.0000000000004905 70.0
HKD2_k127_4047811_8 - - - - 0.000000000001727 72.0
HKD2_k127_4047811_9 FixH K09926 - - 0.000000006902 59.0
HKD2_k127_4048329_0 COGs COG5616 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 366.0
HKD2_k127_4048329_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.0000000000000000000000000000000000000000000000000000000000000003333 225.0
HKD2_k127_4048329_2 Belongs to the bacterial solute-binding protein 9 family - - - 0.000000000000000000000000000000000000000000000000003793 192.0
HKD2_k127_4054917_0 Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005449 421.0
HKD2_k127_4054917_1 Putative zinc-finger - - - 0.0000000000000000000000000000000000000004819 160.0
HKD2_k127_4054917_2 DDE domain K07498 - - 0.000000000000000000000000000000000000004361 151.0
HKD2_k127_4054917_3 Cytochrome c - - - 0.00000000000000000000000000000000000003206 156.0
HKD2_k127_4054917_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000005386 145.0
HKD2_k127_4054917_5 Transposase - - - 0.00000000000000000008144 92.0
HKD2_k127_4054917_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000009066 80.0
HKD2_k127_4054917_7 Arylsulfatase K01130 - 3.1.6.1 0.00009159 48.0
HKD2_k127_4143082_0 Domain of unknown function (DUF1974) K06445 - - 1.805e-292 919.0
HKD2_k127_4143082_1 molybdopterin cofactor binding K08352 - 1.8.5.5 3.204e-223 698.0
HKD2_k127_4143082_2 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 4.817e-217 683.0
HKD2_k127_4143082_3 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007183 406.0
HKD2_k127_4143082_4 3-oxoadipate enol-lactonase K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000004978 268.0
HKD2_k127_4143082_5 Protein of unknown function (DUF3667) - - - 0.00000000000000000000000000000000000004262 160.0
HKD2_k127_4143082_6 Domain of unknown function (DUF4286) - - - 0.000000000000000000001386 109.0
HKD2_k127_4147645_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 529.0
HKD2_k127_4147645_1 Lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000768 317.0
HKD2_k127_4147645_2 ThiJ/PfpI family-like K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 297.0
HKD2_k127_4147645_3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008156 287.0
HKD2_k127_4147645_4 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001504 286.0
HKD2_k127_4147645_5 Belongs to the ATCase OTCase family K09065,K13043 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000001414 254.0
HKD2_k127_4147645_6 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000001784 265.0
HKD2_k127_4147645_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000002128 199.0
HKD2_k127_4147645_8 EamA-like transporter family K08978 - - 0.00000000000000000000000000000000000000000000001679 174.0
HKD2_k127_4147645_9 Protein of unknown function (DUF1203) - - - 0.0000000000000000000000000000000000000000000832 164.0
HKD2_k127_4191506_0 Glycine cleavage T-protein C-terminal barrel domain K00302,K22086 - 1.5.3.1,1.5.99.5 0.0 1334.0
HKD2_k127_4191506_1 Belongs to the GcvT family K00315 - 1.5.8.4 0.0 1267.0
HKD2_k127_4191506_10 signal sequence binding K07152 - - 0.00000000000000000000000000000000000000000000000000000000003883 214.0
HKD2_k127_4191506_11 Sarcosine oxidase, gamma subunit K00305,K22087 - 1.5.3.1,1.5.99.5 0.000000000000000000000000000000000001249 151.0
HKD2_k127_4191506_12 Sarcosine oxidase, delta subunit family K00304,K22085 - 1.5.3.1,1.5.99.5 0.00000000000000000000000000000000000672 138.0
HKD2_k127_4191506_13 - - - - 0.000000000000000000000000003427 129.0
HKD2_k127_4191506_14 oxygen carrier activity K07216 - - 0.0000000000000000000000000483 120.0
HKD2_k127_4191506_15 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.000000000005178 67.0
HKD2_k127_4191506_2 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 1.211e-232 729.0
HKD2_k127_4191506_3 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 7.911e-228 738.0
HKD2_k127_4191506_4 FAD dependent oxidoreductase K00303,K22084 - 1.5.3.1,1.5.99.5 2.899e-224 704.0
HKD2_k127_4191506_5 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 571.0
HKD2_k127_4191506_6 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 512.0
HKD2_k127_4191506_7 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 295.0
HKD2_k127_4191506_8 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000001042 261.0
HKD2_k127_4191506_9 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000007495 236.0
HKD2_k127_4215173_0 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 436.0
HKD2_k127_4215173_1 alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009067 430.0
HKD2_k127_4215173_2 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000001163 127.0
HKD2_k127_4220723_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 411.0
HKD2_k127_4220723_1 abc transporter atp-binding protein K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006649 344.0
HKD2_k127_4220723_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 301.0
HKD2_k127_4220723_3 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000225 259.0
HKD2_k127_4231768_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 3.207e-307 948.0
HKD2_k127_4231768_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 6.316e-280 868.0
HKD2_k127_4231768_10 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 344.0
HKD2_k127_4231768_11 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 332.0
HKD2_k127_4231768_12 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 314.0
HKD2_k127_4231768_13 The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters K02170 - 3.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000001513 247.0
HKD2_k127_4231768_14 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000003249 232.0
HKD2_k127_4231768_15 - - - - 0.0000000000000000000000000000000000000000000000000000000007885 213.0
HKD2_k127_4231768_16 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000000000000000000000000000000002113 203.0
HKD2_k127_4231768_17 Competence protein - - - 0.000000000000000000000000000000000000000000000000000008974 197.0
HKD2_k127_4231768_18 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000000000000004228 190.0
HKD2_k127_4231768_19 signal sequence binding K07152 - - 0.000000000000000000000000000000000000000000000000000117 213.0
HKD2_k127_4231768_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 3.353e-265 834.0
HKD2_k127_4231768_20 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000006664 191.0
HKD2_k127_4231768_21 Prokaryotic Cytochrome C oxidase subunit IV - - - 0.0000000000000000000000000000000000003584 145.0
HKD2_k127_4231768_22 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000003748 104.0
HKD2_k127_4231768_23 Integral membrane protein (DUF2244) - - - 0.000000000000000000013 100.0
HKD2_k127_4231768_24 Cytochrome c oxidase assembly protein CtaG/Cox11 K02258 - - 0.0000000000000000002 95.0
HKD2_k127_4231768_3 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 7.875e-265 838.0
HKD2_k127_4231768_4 COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 536.0
HKD2_k127_4231768_5 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 459.0
HKD2_k127_4231768_6 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 440.0
HKD2_k127_4231768_7 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008355 435.0
HKD2_k127_4231768_8 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003626 365.0
HKD2_k127_4231768_9 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 373.0
HKD2_k127_4305045_0 Amidohydrolase family K06015 - 3.5.1.81 3.193e-255 797.0
HKD2_k127_4305045_1 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 468.0
HKD2_k127_4305045_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 429.0
HKD2_k127_4305045_3 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 370.0
HKD2_k127_4305045_4 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000008994 172.0
HKD2_k127_4305045_5 - - - - 0.0000000000000000000000000000000000000000004763 159.0
HKD2_k127_4305045_6 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000002338 130.0
HKD2_k127_4305045_7 HAD superfamily, subfamily IIIB (Acid phosphatase) - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000005954 120.0
HKD2_k127_4321051_0 Peptidase M16 - - - 0.0 1062.0
HKD2_k127_4321051_1 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 2.062e-234 738.0
HKD2_k127_4321051_10 SBF-like CPA transporter family (DUF4137) K03453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 328.0
HKD2_k127_4321051_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 289.0
HKD2_k127_4321051_12 COG1454 Alcohol dehydrogenase, class IV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005293 268.0
HKD2_k127_4321051_13 membrane transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001267 261.0
HKD2_k127_4321051_14 COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - 0.000000000000000000000000000000000000000000000000000000005696 217.0
HKD2_k127_4321051_15 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000001293 211.0
HKD2_k127_4321051_16 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000007174 202.0
HKD2_k127_4321051_17 Exopolysaccharide synthesis, ExoD - - - 0.000000000000000000000000000000000000000000001552 178.0
HKD2_k127_4321051_18 OmpW family K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000007392 167.0
HKD2_k127_4321051_19 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000001059 115.0
HKD2_k127_4321051_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K20034 - 6.2.1.44 4.307e-203 646.0
HKD2_k127_4321051_20 Belongs to the ompA family K03286 - - 0.00001673 56.0
HKD2_k127_4321051_21 Protein of unknown function (DUF3047) - - - 0.0001477 46.0
HKD2_k127_4321051_22 Protein of unknown function (DUF2505) - - - 0.0003502 49.0
HKD2_k127_4321051_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11745,K11747 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 599.0
HKD2_k127_4321051_4 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 484.0
HKD2_k127_4321051_5 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 449.0
HKD2_k127_4321051_6 Alpha-amylase domain K01176 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 455.0
HKD2_k127_4321051_7 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 424.0
HKD2_k127_4321051_8 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 410.0
HKD2_k127_4321051_9 WYL domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 340.0
HKD2_k127_4350851_0 Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine K00544,K00548 - 2.1.1.13,2.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 384.0
HKD2_k127_4350851_1 gag-polyprotein putative aspartyl protease - - - 0.000000000000000000000000000000000007062 149.0
HKD2_k127_4401066_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 594.0
HKD2_k127_4401066_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00529 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 445.0
HKD2_k127_4401066_2 N-terminal domain of oxidoreductase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 424.0
HKD2_k127_4401066_3 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005819 369.0
HKD2_k127_4401066_4 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.0000000000000000000000000000000000000000000000000000001691 215.0
HKD2_k127_4401066_5 Belongs to the P(II) protein family K04752 GO:0003674,GO:0005488,GO:0005515,GO:0006808,GO:0008150,GO:0042802,GO:0045848,GO:0048518,GO:0050789,GO:0065007 - 0.00000000000000000000000000000000000000000000000002257 181.0
HKD2_k127_4401066_6 Ferredoxin K02230 - 6.6.1.2 0.000000000000000000000000000000003131 133.0
HKD2_k127_4401066_7 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00001791 49.0
HKD2_k127_4402620_0 PFAM Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 586.0
HKD2_k127_4402620_1 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 480.0
HKD2_k127_4402620_2 Phospholipase D. Active site motifs. K06132 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 483.0
HKD2_k127_4402620_3 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000006199 214.0
HKD2_k127_4402620_4 Fatty acid desaturase - - - 0.0000000000000000000005214 96.0
HKD2_k127_4402620_5 6-phosphogluconolactonase activity K20276 - - 0.0000181 55.0
HKD2_k127_4420226_0 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 381.0
HKD2_k127_4420226_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 332.0
HKD2_k127_4420226_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000145 262.0
HKD2_k127_44514_0 Carboxypeptidase K13049 - - 3.681e-195 621.0
HKD2_k127_44514_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 598.0
HKD2_k127_44514_2 DNA mediated transformation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 439.0
HKD2_k127_44514_3 - - - - 0.00000000000000000000000000000000000005224 165.0
HKD2_k127_4498055_0 Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second K01958 - 6.4.1.1 0.0 1572.0
HKD2_k127_4498055_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007523 502.0
HKD2_k127_4498055_10 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000216 133.0
HKD2_k127_4498055_11 Protein-glutamate methylesterase K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000003256 107.0
HKD2_k127_4498055_12 MerR HTH family regulatory protein K18997 - - 0.000000000000000007118 87.0
HKD2_k127_4498055_13 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000008167 81.0
HKD2_k127_4498055_2 DnaJ-class molecular chaperone K05516 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 386.0
HKD2_k127_4498055_3 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 384.0
HKD2_k127_4498055_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005162 361.0
HKD2_k127_4498055_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002051 272.0
HKD2_k127_4498055_6 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000135 240.0
HKD2_k127_4498055_7 Asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000000000000000000001177 228.0
HKD2_k127_4498055_8 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000001515 214.0
HKD2_k127_4498055_9 Thioredoxin K03672 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000271 199.0
HKD2_k127_4499123_0 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 5.962e-277 854.0
HKD2_k127_4499123_1 Conserved carboxylase domain K01571 - 4.1.1.3 1.193e-220 692.0
HKD2_k127_4499123_2 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 531.0
HKD2_k127_4499123_3 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007162 450.0
HKD2_k127_4499123_4 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001632 288.0
HKD2_k127_4499123_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000007218 187.0
HKD2_k127_4660898_0 Radical SAM K01012 - 2.8.1.6 8.491e-214 672.0
HKD2_k127_4660898_1 Mo-co oxidoreductase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 547.0
HKD2_k127_4660898_10 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007957 249.0
HKD2_k127_4660898_11 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000006159 247.0
HKD2_k127_4660898_12 - K07112 - - 0.000000000000000000000000000000000000000000000000000000000000001611 223.0
HKD2_k127_4660898_13 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000000000000000000000000000000000000005683 218.0
HKD2_k127_4660898_14 GMP synthase (glutamine-hydrolyzing) activity - - - 0.000000000000000000000000000000000000000000000000000000000001255 221.0
HKD2_k127_4660898_15 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K00406,K01011,K07112 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000001214 153.0
HKD2_k127_4660898_16 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000000000000000001348 110.0
HKD2_k127_4660898_17 cytochrome C oxidoreductase subunit B - - - 0.000000000000000000006486 95.0
HKD2_k127_4660898_2 Radical SAM K09711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 527.0
HKD2_k127_4660898_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352 - 1.8.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 510.0
HKD2_k127_4660898_4 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 412.0
HKD2_k127_4660898_5 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 411.0
HKD2_k127_4660898_6 biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 369.0
HKD2_k127_4660898_7 4 iron, 4 sulfur cluster binding K04014,K08353,K08358,K16293 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 306.0
HKD2_k127_4660898_8 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007978 306.0
HKD2_k127_4660898_9 Conserved hypothetical protein 698 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001034 284.0
HKD2_k127_468964_0 COG2015 Alkyl sulfatase and related hydrolases K01138 - - 4.18e-306 951.0
HKD2_k127_468964_1 arylsulfatase A K01130 - 3.1.6.1 3.63e-283 876.0
HKD2_k127_468964_10 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 406.0
HKD2_k127_468964_11 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 403.0
HKD2_k127_468964_12 S-acyltransferase activity K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 375.0
HKD2_k127_468964_13 abc transporter, permease K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 361.0
HKD2_k127_468964_14 Binding-protein-dependent transport system inner membrane component K02038 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007736 330.0
HKD2_k127_468964_15 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002593 282.0
HKD2_k127_468964_17 ABC-type molybdate transport system periplasmic component K02020 GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015689,GO:0015698,GO:0030973,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:1901359 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001504 252.0
HKD2_k127_468964_18 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000001627 243.0
HKD2_k127_468964_19 Transcriptional regulator K02019 - - 0.00000000000000000000000000000000000000000000000000000000000000000002297 241.0
HKD2_k127_468964_2 Heavy metal translocating P-type atpase K17686 - 3.6.3.54 2.423e-276 868.0
HKD2_k127_468964_20 helix_turn_helix, mercury resistance K19591 - - 0.00000000000000000000000000000000000000000000000000000000000007439 215.0
HKD2_k127_468964_21 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000006428 202.0
HKD2_k127_468964_22 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000002722 171.0
HKD2_k127_468964_23 Putative MetA-pathway of phenol degradation - - - 0.00000000000000000002006 102.0
HKD2_k127_468964_24 Heavy-metal-associated domain K07213 - - 0.000000000000006419 78.0
HKD2_k127_468964_3 Binding-protein-dependent transport systems inner membrane component K02050 - - 2.985e-229 722.0
HKD2_k127_468964_4 GMC oxidoreductase K03333 - 1.1.3.6 2.404e-225 709.0
HKD2_k127_468964_5 PFAM thiamine pyrophosphate protein TPP binding domain protein - - - 4.579e-212 672.0
HKD2_k127_468964_6 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 602.0
HKD2_k127_468964_7 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 587.0
HKD2_k127_468964_8 FimV N-terminal domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 467.0
HKD2_k127_468964_9 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004722 447.0
HKD2_k127_4695341_0 Sulfate permease family - - - 6.863e-216 684.0
HKD2_k127_4695341_1 Phosphoglucose isomerase K01810 - 5.3.1.9 6.015e-204 639.0
HKD2_k127_4695341_2 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007108 403.0
HKD2_k127_4695341_3 membrane - - - 0.000000000000000000000000000003379 126.0
HKD2_k127_4695341_4 membrane - - - 0.00001817 49.0
HKD2_k127_4794241_0 COG3547 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 537.0
HKD2_k127_4794241_1 transposase activity - - - 0.000000000000000000000000000000000001333 145.0
HKD2_k127_489551_0 Cyclopropane-fatty-acyl-phospholipid synthase K00574 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 475.0
HKD2_k127_489551_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009392 343.0
HKD2_k127_489551_2 Domain of unknown function(DUF2779) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 351.0
HKD2_k127_489551_3 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000003094 226.0
HKD2_k127_489551_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000001288 166.0
HKD2_k127_489551_5 - - - - 0.0000000000000000000000000000000000000038 158.0
HKD2_k127_489551_6 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000000000000000000000000000000001101 150.0
HKD2_k127_489551_7 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000000001122 140.0
HKD2_k127_489551_8 - - - - 0.0000000000000000000000000000367 126.0
HKD2_k127_489551_9 Peptidoglycan-binding domain 1 protein - - - 0.000000001889 65.0
HKD2_k127_493064_0 Cys Met metabolism pyridoxal-phosphate-dependent enzyme - - - 4.502e-246 784.0
HKD2_k127_493064_1 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 2.913e-232 725.0
HKD2_k127_493064_10 Histidine kinase - - - 0.00000000241 59.0
HKD2_k127_493064_2 Cytochrome c5530 family protein - - - 4.83e-206 659.0
HKD2_k127_493064_3 Cytochrome c5530 family protein - - - 1.423e-204 653.0
HKD2_k127_493064_4 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 438.0
HKD2_k127_493064_5 Surface antigen K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 421.0
HKD2_k127_493064_6 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 392.0
HKD2_k127_493064_7 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 368.0
HKD2_k127_493064_8 Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 354.0
HKD2_k127_5109055_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01006 - 2.7.9.1 0.0 1408.0
HKD2_k127_5109055_1 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate K01782,K01825 GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 0.0 1055.0
HKD2_k127_5109055_10 oxidoreductase K09471 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005554 504.0
HKD2_k127_5109055_11 PFAM fatty acid hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 469.0
HKD2_k127_5109055_12 Phosphoribulokinase / Uridine kinase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003392 446.0
HKD2_k127_5109055_13 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K01086,K03841 - 3.1.3.11,3.1.3.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 451.0
HKD2_k127_5109055_14 CbbX protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 411.0
HKD2_k127_5109055_15 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 374.0
HKD2_k127_5109055_16 TGS domain K06944 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 347.0
HKD2_k127_5109055_17 Esterase of the alpha-beta hydrolase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004534 339.0
HKD2_k127_5109055_18 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001977 259.0
HKD2_k127_5109055_19 Ribulose bisphosphate carboxylase, small chain K01602 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000004626 209.0
HKD2_k127_5109055_2 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 1.038e-276 855.0
HKD2_k127_5109055_20 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000002248 200.0
HKD2_k127_5109055_21 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.00000000000000000000000000000000000000000000000000005093 203.0
HKD2_k127_5109055_22 cdp-diacylglycerol--glycerol-3-phosphate - - - 0.000000000000000000000000000000000000000005052 163.0
HKD2_k127_5109055_23 YhhN family - - - 0.0000000000000000000000000000000000000002427 166.0
HKD2_k127_5109055_24 - - - - 0.0000000000000000000000000000000000000006868 155.0
HKD2_k127_5109055_25 - - - - 0.0000000000000000000000000000000000877 143.0
HKD2_k127_5109055_26 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00632 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 0.0000000000000000000000000000000001985 133.0
HKD2_k127_5109055_27 LysR substrate binding domain K21703 - - 0.0000000000415 64.0
HKD2_k127_5109055_29 Outer membrane protein W K07275 - - 0.0001206 52.0
HKD2_k127_5109055_3 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 2.98e-274 873.0
HKD2_k127_5109055_4 Flavin containing amine oxidoreductase K09516 - 1.3.99.23 6.888e-241 754.0
HKD2_k127_5109055_5 Protein of unknown function (DUF1343) - - - 6.744e-211 661.0
HKD2_k127_5109055_6 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 3.826e-210 663.0
HKD2_k127_5109055_7 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 2.145e-200 635.0
HKD2_k127_5109055_8 Lytic murein transglycosylase K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 618.0
HKD2_k127_5109055_9 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 524.0
HKD2_k127_5110690_0 Beta-ketoacyl synthase, C-terminal domain K18473 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008904 415.0
HKD2_k127_5110690_1 aminopeptidase - - - 0.0000000000000000000000000000000000000004792 156.0
HKD2_k127_5110720_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 591.0
HKD2_k127_5110720_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 460.0
HKD2_k127_5110720_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 384.0
HKD2_k127_5110720_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000807 231.0
HKD2_k127_5110720_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000007649 176.0
HKD2_k127_5110720_5 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000001672 83.0
HKD2_k127_51486_0 Efflux pump K03296,K18138,K18322 - - 0.0 1577.0
HKD2_k127_51486_1 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0 1098.0
HKD2_k127_51486_10 Glycosyl hydrolases family 15 - - - 2.291e-219 698.0
HKD2_k127_51486_11 Belongs to the TPP enzyme family K01576 - 4.1.1.7 1.033e-206 656.0
HKD2_k127_51486_12 Peptidase dimerisation domain - - - 1.527e-206 647.0
HKD2_k127_51486_13 PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B K04099 - 1.13.11.57 8.075e-194 616.0
HKD2_k127_51486_14 4-oxalomesaconate hydratase K03392,K10220 - 4.1.1.45,4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 601.0
HKD2_k127_51486_15 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 591.0
HKD2_k127_51486_16 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005148 548.0
HKD2_k127_51486_17 Outer membrane efflux protein K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 529.0
HKD2_k127_51486_18 Domain of Unknown Function (DUF349) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 544.0
HKD2_k127_51486_19 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 514.0
HKD2_k127_51486_2 Protein of unknown function (DUF3604) - - - 0.0 1078.0
HKD2_k127_51486_20 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 511.0
HKD2_k127_51486_21 PFAM Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 487.0
HKD2_k127_51486_22 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007714 478.0
HKD2_k127_51486_23 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 473.0
HKD2_k127_51486_24 protein conserved in bacteria K16514 GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 5.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 470.0
HKD2_k127_51486_25 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 474.0
HKD2_k127_51486_26 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04099,K04101 - 1.13.11.57,1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 468.0
HKD2_k127_51486_27 Major Facilitator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 451.0
HKD2_k127_51486_28 Chloride channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 447.0
HKD2_k127_51486_29 Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA K18383 - 4.1.2.41,4.2.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 434.0
HKD2_k127_51486_3 iron-nicotianamine transmembrane transporter activity - - - 5.446e-311 972.0
HKD2_k127_51486_30 oxidoreductases (related to aryl-alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 449.0
HKD2_k127_51486_31 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 374.0
HKD2_k127_51486_32 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 368.0
HKD2_k127_51486_33 PPIC-type PPIASE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 323.0
HKD2_k127_51486_34 Aldolase/RraA K02553,K10218 - 4.1.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 322.0
HKD2_k127_51486_35 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 310.0
HKD2_k127_51486_36 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 293.0
HKD2_k127_51486_37 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007662 287.0
HKD2_k127_51486_38 Glutathione S-Transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005153 279.0
HKD2_k127_51486_39 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002422 279.0
HKD2_k127_51486_4 Sulfatase K01130 - 3.1.6.1 9.622e-306 947.0
HKD2_k127_51486_40 Response regulator of the LytR AlgR family K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002727 263.0
HKD2_k127_51486_41 IQR COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007748 265.0
HKD2_k127_51486_42 6-phosphogluconate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003972 264.0
HKD2_k127_51486_43 LysR substrate binding domain K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009995 250.0
HKD2_k127_51486_44 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000002012 235.0
HKD2_k127_51486_45 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000007208 213.0
HKD2_k127_51486_46 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000007829 215.0
HKD2_k127_51486_47 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.000000000000000000000000000000000000000000000000000000001273 209.0
HKD2_k127_51486_48 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000001686 205.0
HKD2_k127_51486_49 - - - - 0.000000000000000000000000000000000000000000000000000000787 201.0
HKD2_k127_51486_5 E1-E2 ATPase K01535 - 3.6.3.6 4.959e-305 956.0
HKD2_k127_51486_50 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000003609 194.0
HKD2_k127_51486_51 carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000000000000000000000006801 189.0
HKD2_k127_51486_52 BetI-type transcriptional repressor, C-terminal - - - 0.000000000000000000000000000000000000000000001111 183.0
HKD2_k127_51486_53 - - - - 0.00000000000000000000000000000000000000001887 156.0
HKD2_k127_51486_54 GYD domain - - - 0.00000000000000000000000000009594 118.0
HKD2_k127_51486_55 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000007823 108.0
HKD2_k127_51486_56 Cupin 2, conserved barrel domain protein K21700 - - 0.000000000000000000000002274 107.0
HKD2_k127_51486_57 Dodecin K09165 - - 0.00000000000000000000003683 103.0
HKD2_k127_51486_58 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.0000000000000000000000611 108.0
HKD2_k127_51486_6 M3B, thimet oligopeptidase F K01392 - 3.4.24.15 5.053e-262 823.0
HKD2_k127_51486_60 Histidine kinase - - - 0.000000003248 69.0
HKD2_k127_51486_61 - - - - 0.000000005123 65.0
HKD2_k127_51486_62 NADPH-dependent FMN reductase K19784 - - 0.00002848 49.0
HKD2_k127_51486_7 belongs to the aldehyde dehydrogenase family K00146 - 1.2.1.39 2.273e-248 779.0
HKD2_k127_51486_8 Belongs to the TPP enzyme family K01652 - 2.2.1.6 2.158e-235 741.0
HKD2_k127_51486_9 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 6.34e-225 724.0
HKD2_k127_5182662_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 1.526e-308 961.0
HKD2_k127_5182662_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.377e-210 666.0
HKD2_k127_5182662_10 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication K06980 GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000001041 156.0
HKD2_k127_5182662_11 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.000000000000000000000000000001675 124.0
HKD2_k127_5182662_12 protein conserved in bacteria - - - 0.00000000000000000000000000005291 128.0
HKD2_k127_5182662_13 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000007956 125.0
HKD2_k127_5182662_14 succinate dehydrogenase - - - 0.0000000000000000000001397 115.0
HKD2_k127_5182662_15 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.00000000000000000001154 95.0
HKD2_k127_5182662_16 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000002056 76.0
HKD2_k127_5182662_17 Protein of unknown function (DUF1674) - - - 0.00000000008419 73.0
HKD2_k127_5182662_2 COG0608 Single-stranded DNA-specific exonuclease K07462 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 574.0
HKD2_k127_5182662_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 512.0
HKD2_k127_5182662_4 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006895 437.0
HKD2_k127_5182662_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 331.0
HKD2_k127_5182662_6 Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 299.0
HKD2_k127_5182662_7 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000001885 271.0
HKD2_k127_5182662_8 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.000000000000000000000000000000000000000000000000000000000000000001061 240.0
HKD2_k127_5182662_9 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000001082 220.0
HKD2_k127_5218071_0 Phosphoenolpyruvate phosphomutase K20454 - 4.1.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 356.0
HKD2_k127_5218071_1 Sugar (and other) transporter K08178 - - 0.0000000000000000009599 99.0
HKD2_k127_5223036_0 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 - 2.1.1.173,2.1.1.264 1.28e-242 770.0
HKD2_k127_5223036_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 8.55e-218 686.0
HKD2_k127_5223036_10 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 470.0
HKD2_k127_5223036_11 GIY-YIG type nucleases (URI domain) K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 449.0
HKD2_k127_5223036_12 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 437.0
HKD2_k127_5223036_13 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009766 399.0
HKD2_k127_5223036_14 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 326.0
HKD2_k127_5223036_15 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 301.0
HKD2_k127_5223036_16 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002837 240.0
HKD2_k127_5223036_17 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000008855 237.0
HKD2_k127_5223036_18 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000000000000000000000000000000000000000000001786 229.0
HKD2_k127_5223036_19 Isochorismatase family K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000000000001046 222.0
HKD2_k127_5223036_2 Belongs to the RtcB family K14415,K18148 - 6.5.1.3 2.49e-217 683.0
HKD2_k127_5223036_20 synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000000000000000007477 213.0
HKD2_k127_5223036_21 Archease protein family (MTH1598/TM1083) - - - 0.000000000000000000000000000000000000000000005008 175.0
HKD2_k127_5223036_22 universal stress protein K14055 - - 0.0000000000000000000000000000000000000000001099 171.0
HKD2_k127_5223036_23 PFAM Cold-shock protein, DNA-binding - - - 0.000000000000000000000000000001087 124.0
HKD2_k127_5223036_24 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000002618 129.0
HKD2_k127_5223036_25 transcriptional regulator K06995 - - 0.00000000000000000000000000003312 121.0
HKD2_k127_5223036_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K12256 - 2.6.1.113 1.922e-213 671.0
HKD2_k127_5223036_4 Belongs to the aldehyde dehydrogenase family K00130,K09472,K12254 - 1.2.1.54,1.2.1.8,1.2.1.99 5.664e-213 672.0
HKD2_k127_5223036_5 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 3.633e-195 617.0
HKD2_k127_5223036_6 oxidoreductase K09471 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005802 514.0
HKD2_k127_5223036_7 Nicotinate phosphoribosyltransferase (NAPRTase) family K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 514.0
HKD2_k127_5223036_8 Bifunctional enoyl-CoA hydratase phosphate acetyltransferase K00625,K00634 - 2.3.1.19,2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 512.0
HKD2_k127_5223036_9 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 472.0
HKD2_k127_5254279_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 2.833e-240 758.0
HKD2_k127_5254279_1 Belongs to the GppA Ppx family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 501.0
HKD2_k127_5254279_10 Required for insertion of 4Fe-4S clusters K15724 - - 0.000000000000000000000000000000000000000000000000001117 185.0
HKD2_k127_5254279_11 Protein of unknown function, DUF484 - - - 0.000000000000000000000000000000000000006717 158.0
HKD2_k127_5254279_12 - - - - 0.000000000000514 78.0
HKD2_k127_5254279_2 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 435.0
HKD2_k127_5254279_3 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003788 411.0
HKD2_k127_5254279_4 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006911 325.0
HKD2_k127_5254279_5 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000697 230.0
HKD2_k127_5254279_6 Conserved TM helix - - - 0.0000000000000000000000000000000000000000000000000000000001371 208.0
HKD2_k127_5254279_7 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.0000000000000000000000000000000000000000000000000000000003357 211.0
HKD2_k127_5254279_8 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000004026 206.0
HKD2_k127_5254279_9 - - - - 0.0000000000000000000000000000000000000000000000000000000937 218.0
HKD2_k127_5263757_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 3.845e-266 830.0
HKD2_k127_5263757_1 Polysaccharide biosynthesis C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 507.0
HKD2_k127_5263757_10 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000000000000000009548 181.0
HKD2_k127_5263757_11 KR domain K07124 - - 0.00000000000000000000000000000000000000001461 163.0
HKD2_k127_5263757_12 Domain of unknown function (DUF1840) - - - 0.00000000000003965 76.0
HKD2_k127_5263757_13 PFAM 4Fe-4S ferredoxin iron-sulfur binding - - - 0.000009544 57.0
HKD2_k127_5263757_2 ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 408.0
HKD2_k127_5263757_3 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007257 406.0
HKD2_k127_5263757_4 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 391.0
HKD2_k127_5263757_5 Putative esterase K07214 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 361.0
HKD2_k127_5263757_6 Enoyl-CoA hydratase carnithine racemase K01692 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000006035 267.0
HKD2_k127_5263757_7 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001064 276.0
HKD2_k127_5263757_8 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000007547 214.0
HKD2_k127_5263757_9 Belongs to the peptidase S51 family - - - 0.000000000000000000000000000000000000000000000001476 193.0
HKD2_k127_5292406_0 serine dehydratase beta chain K01752 - 4.3.1.17 5.094e-240 752.0
HKD2_k127_5292406_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008667 565.0
HKD2_k127_5292406_2 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 550.0
HKD2_k127_5292406_3 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009266 435.0
HKD2_k127_5292406_4 PFAM Bacterial regulatory helix-turn-helix proteins, AraC family - - - 0.000000000000000000000000000000000000000000000000000000000121 217.0
HKD2_k127_5292406_5 Pyruvate formate lyase-like K00656 - 2.3.1.54 0.0000000000000000000000000000000000000006121 151.0
HKD2_k127_5292406_6 VIT family - - - 0.000000000000000000000000000000000000001599 155.0
HKD2_k127_5292406_7 Bile acid K03453 - - 0.000000000001169 72.0
HKD2_k127_5307441_0 Bifunctional purine biosynthesis protein PurH K00602 GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 9.641e-222 702.0
HKD2_k127_5307441_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 556.0
HKD2_k127_5307441_10 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000000000000000000001471 200.0
HKD2_k127_5307441_11 glycosyl transferase family - - - 0.0000000000000000000000000000000000000000000000001853 195.0
HKD2_k127_5307441_12 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000006166 179.0
HKD2_k127_5307441_13 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000003297 164.0
HKD2_k127_5307441_14 Psort location CytoplasmicMembrane, score 10.00 - - - 0.0000000000000000000000000000005557 142.0
HKD2_k127_5307441_15 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters K03557 - - 0.00000000000000000001472 96.0
HKD2_k127_5307441_16 Protein of unknown function (DUF3426) - - - 0.0000000000000002949 84.0
HKD2_k127_5307441_2 Belongs to the GARS family K01945,K13713 GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 537.0
HKD2_k127_5307441_3 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 452.0
HKD2_k127_5307441_4 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 430.0
HKD2_k127_5307441_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 409.0
HKD2_k127_5307441_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 395.0
HKD2_k127_5307441_7 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003009 281.0
HKD2_k127_5307441_8 YdjC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000125 273.0
HKD2_k127_5307441_9 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000001025 180.0
HKD2_k127_5434148_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 601.0
HKD2_k127_5434148_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009645 321.0
HKD2_k127_5434148_10 Putative ephrin-receptor like - - - 0.000003167 60.0
HKD2_k127_5434148_11 PKD domain containing protein - - - 0.0001161 55.0
HKD2_k127_5434148_2 protein involved in response to NO K07234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 314.0
HKD2_k127_5434148_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004102 282.0
HKD2_k127_5434148_4 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000000000000000000000000000000000000000000000000000000008578 236.0
HKD2_k127_5434148_5 PFAM MaoC domain protein dehydratase - - - 0.000000000000000000000000000000000002817 155.0
HKD2_k127_5434148_6 PEP-CTERM motif - - - 0.00000000000000000000000000000004124 144.0
HKD2_k127_5434148_7 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000000000002499 112.0
HKD2_k127_5434148_8 WHG domain - - - 0.0000000000000000000000009195 111.0
HKD2_k127_5434148_9 PFAM glycosyl transferase family 39 - - - 0.0000000000001702 80.0
HKD2_k127_5450465_0 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 550.0
HKD2_k127_5450465_1 FAD dependent oxidoreductase central domain K00315 - 1.5.8.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 378.0
HKD2_k127_5450465_2 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009122 295.0
HKD2_k127_5450465_3 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000006265 163.0
HKD2_k127_5556466_0 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 617.0
HKD2_k127_5556466_1 dehydrogenase e1 component K21416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 417.0
HKD2_k127_5556466_2 Transketolase, pyrimidine binding domain K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 415.0
HKD2_k127_5556466_3 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005667 344.0
HKD2_k127_5556466_4 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000007272 87.0
HKD2_k127_5586835_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008856 304.0
HKD2_k127_5586835_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001838 278.0
HKD2_k127_5586835_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000002652 241.0
HKD2_k127_5586835_3 - - - - 0.0000000000000001046 83.0
HKD2_k127_5586835_4 - - - - 0.00004516 53.0
HKD2_k127_5614860_0 DEAD DEAH box helicase K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 485.0
HKD2_k127_5614860_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 288.0
HKD2_k127_5614860_2 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000001239 179.0
HKD2_k127_6020901_0 acyl-CoA dehydrogenase - - - 5.357e-227 717.0
HKD2_k127_6020901_1 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 593.0
HKD2_k127_6020901_10 Acyl-CoA synthetase (NDP forming) K09181 - - 0.00000000000000000000000000001059 125.0
HKD2_k127_6020901_11 DNA-binding transcription factor activity - - - 0.00000000000000000000000000002186 123.0
HKD2_k127_6020901_12 Cyclic nucleotide-monophosphate binding domain K10914 - - 0.00000000000000000000000005262 117.0
HKD2_k127_6020901_13 CHAD - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000002973 86.0
HKD2_k127_6020901_14 - - - - 0.00000000028 65.0
HKD2_k127_6020901_15 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are K21029,K21147 - 2.7.7.80,2.8.1.11 0.000001175 55.0
HKD2_k127_6020901_2 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 599.0
HKD2_k127_6020901_3 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 557.0
HKD2_k127_6020901_4 FAD linked oxidases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004547 513.0
HKD2_k127_6020901_5 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 481.0
HKD2_k127_6020901_6 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 423.0
HKD2_k127_6020901_7 Acyl-CoA thioesterase K10805 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 309.0
HKD2_k127_6020901_8 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 304.0
HKD2_k127_6020901_9 Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000000000000001198 186.0
HKD2_k127_6201525_0 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008194 359.0
HKD2_k127_6201525_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 287.0
HKD2_k127_6201525_2 PFAM DoxX family protein K15977 - - 0.00000000000000000000000000000000000000001146 157.0
HKD2_k127_6201525_3 Transcriptional regulator - - - 0.00000000000000000000000000000008318 126.0
HKD2_k127_6400159_0 PQQ-like domain - - - 9.877e-281 880.0
HKD2_k127_6400159_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 5.813e-243 771.0
HKD2_k127_6400159_10 Sporulation related domain - - - 0.0000000000000001314 90.0
HKD2_k127_6400159_11 Protein of unknown function (DUF3106) - - - 0.00000000008431 72.0
HKD2_k127_6400159_12 - - - - 0.00000002202 64.0
HKD2_k127_6400159_14 - - - - 0.00009259 53.0
HKD2_k127_6400159_15 RHS repeat-associated core domain protein - - - 0.0001915 51.0
HKD2_k127_6400159_2 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.598e-233 737.0
HKD2_k127_6400159_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 6.302e-224 715.0
HKD2_k127_6400159_4 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 6.326e-204 640.0
HKD2_k127_6400159_5 Pyridoxal-phosphate dependent enzyme K01697,K01738 - 2.5.1.47,4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 479.0
HKD2_k127_6400159_6 TIR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 353.0
HKD2_k127_6400159_7 Phage lysozyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 332.0
HKD2_k127_6400159_8 Domain of unknown function (DUF4382) - - - 0.00000000000000000000000000000000000000000000000000001483 203.0
HKD2_k127_6400159_9 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog K03088 - - 0.000000000000000000000000000000000000000000000001516 182.0
HKD2_k127_6413690_0 receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 501.0
HKD2_k127_6413690_1 ATP-grasp domain K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 400.0
HKD2_k127_6413690_2 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000004736 244.0
HKD2_k127_6413690_3 MFS_1 like family - - - 0.00000000000000000000000000000000000000000000000000367 198.0
HKD2_k127_6413690_4 acetyltransferase K18815 - 2.3.1.82 0.00000000000000000000000000004806 126.0
HKD2_k127_6413690_5 metal cluster binding K06940,K18475 - - 0.000000000000000000000001358 113.0
HKD2_k127_6413690_6 Flavin containing amine oxidoreductase - - - 0.000000000000001058 91.0
HKD2_k127_6420971_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1394.0
HKD2_k127_6420971_1 Nickel-dependent hydrogenase K06281 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 6.1e-322 991.0
HKD2_k127_6420971_10 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 527.0
HKD2_k127_6420971_11 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007094 522.0
HKD2_k127_6420971_12 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 425.0
HKD2_k127_6420971_13 mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 416.0
HKD2_k127_6420971_14 Sodium/calcium exchanger protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 397.0
HKD2_k127_6420971_15 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 400.0
HKD2_k127_6420971_16 surface antigen variable number repeat protein K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 391.0
HKD2_k127_6420971_17 Surface antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007292 328.0
HKD2_k127_6420971_18 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 320.0
HKD2_k127_6420971_19 Prokaryotic cytochrome b561 K03620 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 297.0
HKD2_k127_6420971_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.149e-276 877.0
HKD2_k127_6420971_20 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K18357 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002835 271.0
HKD2_k127_6420971_21 s cog2930 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000676 235.0
HKD2_k127_6420971_22 Hydrogenase maturation protease K03605 GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000322 224.0
HKD2_k127_6420971_23 HupH hydrogenase expression protein, C-terminal conserved region K03618 - - 0.0000000000000000000000000000000000000000000000000001012 198.0
HKD2_k127_6420971_24 [NiFe]-hydrogenase assembly, chaperone, HybE - - - 0.0000000000000000000000000000000000000000000000000001704 198.0
HKD2_k127_6420971_25 Protein of unknown function, DUF481 - - - 0.000000000000000000000000000000000000000000000000002089 196.0
HKD2_k127_6420971_26 membrane - - - 0.000000000000000000000000000000000000000000000001096 196.0
HKD2_k127_6420971_27 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000003909 183.0
HKD2_k127_6420971_28 - - - - 0.0000000000000000000000000000000000000000000002332 178.0
HKD2_k127_6420971_29 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000003533 171.0
HKD2_k127_6420971_3 Cytochrome c554 and c-prime - - - 1.268e-233 751.0
HKD2_k127_6420971_30 Gram-negative porin - - - 0.0000000000000000000000000000000000000004559 164.0
HKD2_k127_6420971_31 Protein of unknown function (DUF3313) - - - 0.000000000000000000000000000000000000005197 154.0
HKD2_k127_6420971_32 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000003667 137.0
HKD2_k127_6420971_33 PFAM Cyclic nucleotide-binding - - - 0.00000000000000000000000000000003922 132.0
HKD2_k127_6420971_34 Methyltransferase - - - 0.00000000000000000000000009355 106.0
HKD2_k127_6420971_35 YMGG-like Gly-zipper - - - 0.00000000000000000000003668 108.0
HKD2_k127_6420971_36 Hydrogenase-1 expression protein HyaE - - - 0.000000000000002511 80.0
HKD2_k127_6420971_37 - - - - 0.000000000002758 75.0
HKD2_k127_6420971_4 protein conserved in bacteria - - - 4.872e-203 651.0
HKD2_k127_6420971_5 nucleoside-diphosphate sugar epimerase - - - 1.102e-198 629.0
HKD2_k127_6420971_6 pyruvate flavodoxin ferredoxin oxidoreductase K00169 - 1.2.7.1 8.753e-196 623.0
HKD2_k127_6420971_7 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 603.0
HKD2_k127_6420971_8 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005812 587.0
HKD2_k127_6420971_9 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K18356 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 534.0
HKD2_k127_6451084_0 Belongs to the TPP enzyme family K03852 - 2.3.3.15 4.752e-266 839.0
HKD2_k127_6451084_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 1.225e-245 764.0
HKD2_k127_6451084_10 COG4942 Membrane-bound metallopeptidase - GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000004154 241.0
HKD2_k127_6451084_11 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 0.00000000000000000000000000000000000000000000000000000000006275 211.0
HKD2_k127_6451084_12 membrane protein domain - - - 0.0000000000000000000000000000000000000000000000000001301 188.0
HKD2_k127_6451084_13 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000004072 158.0
HKD2_k127_6451084_14 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000002426 172.0
HKD2_k127_6451084_15 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000003485 123.0
HKD2_k127_6451084_16 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000000000000000000000000147 121.0
HKD2_k127_6451084_17 PFAM Rhodanese-like K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000002869 108.0
HKD2_k127_6451084_18 - - - - 0.000000000000253 72.0
HKD2_k127_6451084_19 penicillin-binding protein - - - 0.000000008477 64.0
HKD2_k127_6451084_2 AMP-binding enzyme C-terminal domain K00666 - - 2.735e-242 761.0
HKD2_k127_6451084_3 response regulator K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 591.0
HKD2_k127_6451084_4 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 481.0
HKD2_k127_6451084_5 N-terminal domain of oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 420.0
HKD2_k127_6451084_6 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 364.0
HKD2_k127_6451084_7 signal transduction histidine kinase K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 333.0
HKD2_k127_6451084_8 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 322.0
HKD2_k127_6451084_9 Flagellar basal body rod K02396 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002897 272.0
HKD2_k127_6457269_0 Catalyzes the synthesis of activated sulfate K00955 - 2.7.1.25,2.7.7.4 1.409e-297 921.0
HKD2_k127_6472080_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1071.0
HKD2_k127_6472080_1 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 2.872e-273 848.0
HKD2_k127_6472080_10 Lipase (class 3) K01046 - 3.1.1.3 0.0000000000000000000000000000000000000000000000006045 186.0
HKD2_k127_6472080_11 response to heat - - - 0.000000000000000000000000000000000000000000000001959 180.0
HKD2_k127_6472080_12 - - - - 0.000000000000000000000000000000000000000000000652 181.0
HKD2_k127_6472080_13 fatty acid desaturase - - - 0.000000000000000000000000000000000000001281 160.0
HKD2_k127_6472080_14 fatty acid desaturase - - - 0.000000000000000000000000000000000000008524 157.0
HKD2_k127_6472080_15 Cytochrome P450 - - - 0.00000000000000000000000000000000001187 152.0
HKD2_k127_6472080_16 PFAM Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000001377 138.0
HKD2_k127_6472080_17 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.00000000000000000000000000000007423 133.0
HKD2_k127_6472080_18 integral membrane protein - - - 0.0000000000000000000000007486 114.0
HKD2_k127_6472080_19 Transglycosylase associated protein - - - 0.0000000000000000002098 89.0
HKD2_k127_6472080_2 Adenylate - - - 1.45e-215 704.0
HKD2_k127_6472080_20 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000005419 83.0
HKD2_k127_6472080_22 Cro/C1-type HTH DNA-binding domain - - - 0.00000002687 58.0
HKD2_k127_6472080_23 Bacterial regulatory helix-turn-helix protein, lysR family K05817 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000002492 57.0
HKD2_k127_6472080_24 Acetyltransferase (GNAT) family - - - 0.0002722 51.0
HKD2_k127_6472080_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781 - 5.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008458 572.0
HKD2_k127_6472080_4 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 429.0
HKD2_k127_6472080_5 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005304 274.0
HKD2_k127_6472080_6 UPF0114 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007483 260.0
HKD2_k127_6472080_7 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000001613 245.0
HKD2_k127_6472080_8 Aldo/keto reductase family K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000001221 216.0
HKD2_k127_6472080_9 TspO/MBR family K05770 - - 0.0000000000000000000000000000000000000000000000000000003899 201.0
HKD2_k127_6496267_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1428.0
HKD2_k127_6496267_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1225.0
HKD2_k127_6496267_10 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 4.883e-196 625.0
HKD2_k127_6496267_11 acyl-CoA dehydrogenase activity K09456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 627.0
HKD2_k127_6496267_12 TIGRFAM ribonuclease, Rne Rng family K08301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 619.0
HKD2_k127_6496267_13 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 606.0
HKD2_k127_6496267_14 peptidase M24B, X-Pro dipeptidase aminopeptidase K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003543 596.0
HKD2_k127_6496267_15 Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 549.0
HKD2_k127_6496267_16 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 531.0
HKD2_k127_6496267_17 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 484.0
HKD2_k127_6496267_18 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 486.0
HKD2_k127_6496267_19 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 473.0
HKD2_k127_6496267_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 5.218e-246 766.0
HKD2_k127_6496267_20 (SAM)-dependent K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 456.0
HKD2_k127_6496267_21 4Fe-4S dicluster domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 454.0
HKD2_k127_6496267_22 Splits dipeptides with a prolyl residue in the C- terminal position K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 451.0
HKD2_k127_6496267_23 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 432.0
HKD2_k127_6496267_24 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 429.0
HKD2_k127_6496267_25 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 444.0
HKD2_k127_6496267_26 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 422.0
HKD2_k127_6496267_27 PFAM PhoH family protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 413.0
HKD2_k127_6496267_28 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 407.0
HKD2_k127_6496267_29 PFAM pfkB family carbohydrate kinase K00856 - 2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006902 397.0
HKD2_k127_6496267_3 Protein of unknown function, DUF255 K06888 - - 2.654e-244 773.0
HKD2_k127_6496267_30 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 388.0
HKD2_k127_6496267_31 ABC transporter substrate-binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 379.0
HKD2_k127_6496267_32 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 372.0
HKD2_k127_6496267_33 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 360.0
HKD2_k127_6496267_34 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 359.0
HKD2_k127_6496267_35 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 359.0
HKD2_k127_6496267_36 Protein of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 372.0
HKD2_k127_6496267_37 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K18800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 333.0
HKD2_k127_6496267_38 Belongs to the SUA5 family K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 326.0
HKD2_k127_6496267_39 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 320.0
HKD2_k127_6496267_4 Pro-apoptotic serine protease - - - 3.881e-244 784.0
HKD2_k127_6496267_40 PFAM CBS domain K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 328.0
HKD2_k127_6496267_41 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 323.0
HKD2_k127_6496267_42 ribonuclease BN K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 324.0
HKD2_k127_6496267_43 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008417 307.0
HKD2_k127_6496267_44 Type II secretory pathway component ExeA K02450,K12283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 313.0
HKD2_k127_6496267_45 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 300.0
HKD2_k127_6496267_46 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006858 304.0
HKD2_k127_6496267_47 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006188 280.0
HKD2_k127_6496267_48 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005641 279.0
HKD2_k127_6496267_49 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005002 269.0
HKD2_k127_6496267_5 modulator of DNA gyrase K03568 - - 8.044e-209 665.0
HKD2_k127_6496267_50 DNA polymerase III, delta subunit K02340 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000498 246.0
HKD2_k127_6496267_51 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000005591 238.0
HKD2_k127_6496267_52 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000003134 233.0
HKD2_k127_6496267_53 Predicted integral membrane protein (DUF2189) - - - 0.000000000000000000000000000000000000000000000000000000000000000009441 235.0
HKD2_k127_6496267_54 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000108 236.0
HKD2_k127_6496267_55 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000000000000000000000000000001518 235.0
HKD2_k127_6496267_56 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000002022 222.0
HKD2_k127_6496267_57 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000002452 221.0
HKD2_k127_6496267_58 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 - - 0.0000000000000000000000000000000000000000000000000000000000004579 222.0
HKD2_k127_6496267_59 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000557 212.0
HKD2_k127_6496267_6 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 5.785e-203 646.0
HKD2_k127_6496267_60 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969,K01488 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.5.4.4 0.000000000000000000000000000000000000000000000000000000000003263 227.0
HKD2_k127_6496267_61 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000001265 207.0
HKD2_k127_6496267_62 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000001363 199.0
HKD2_k127_6496267_63 Ubiquinol--cytochrome c reductase - - - 0.0000000000000000000000000000000000000000000000000000001505 198.0
HKD2_k127_6496267_64 Belongs to the ComB family K05979 - 3.1.3.71 0.0000000000000000000000000000000000000000000000000000003594 201.0
HKD2_k127_6496267_65 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000002948 192.0
HKD2_k127_6496267_66 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000000000000000002761 192.0
HKD2_k127_6496267_67 Protein conserved in bacteria K09922 - - 0.00000000000000000000000000000000000000000000000006038 183.0
HKD2_k127_6496267_68 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000009585 192.0
HKD2_k127_6496267_69 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000008303 179.0
HKD2_k127_6496267_7 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 1.723e-201 637.0
HKD2_k127_6496267_70 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000004543 175.0
HKD2_k127_6496267_71 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 - 0.0000000000000000000000000000000000000000000006476 175.0
HKD2_k127_6496267_72 Ribosomal protein L17 K02879 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000002721 164.0
HKD2_k127_6496267_73 bis(5'-adenosyl)-triphosphatase activity - - - 0.0000000000000000000000000000000000000000006404 166.0
HKD2_k127_6496267_74 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000005352 151.0
HKD2_k127_6496267_75 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 0.000000000000000000000000000000000000004092 151.0
HKD2_k127_6496267_76 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000007526 153.0
HKD2_k127_6496267_77 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000009664 150.0
HKD2_k127_6496267_78 redox protein, regulator of disulfide bond formation - - - 0.0000000000000000000000000000000000002917 161.0
HKD2_k127_6496267_79 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000001234 143.0
HKD2_k127_6496267_8 Glycine cleavage system P-protein K00282 - 1.4.4.2 1.214e-199 631.0
HKD2_k127_6496267_80 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000009081 141.0
HKD2_k127_6496267_81 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000000000000225 131.0
HKD2_k127_6496267_82 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 0.000000000000000000000000000005842 127.0
HKD2_k127_6496267_83 Haloacid dehalogenase-like hydrolase K07025,K20866 - 3.1.3.10 0.00000000000000000000000000001379 129.0
HKD2_k127_6496267_84 Belongs to the UPF0307 family K09889 - - 0.0000000000000000000000000006395 119.0
HKD2_k127_6496267_85 Belongs to the UPF0149 family K09895 - - 0.0000000000000000000000001839 118.0
HKD2_k127_6496267_86 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000093 105.0
HKD2_k127_6496267_87 Acetyltransferase - - - 0.0000000000000000007797 94.0
HKD2_k127_6496267_88 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000000000007746 82.0
HKD2_k127_6496267_89 TIGRFAM ribosomal protein L30 K02907 - - 0.00000000001907 73.0
HKD2_k127_6496267_9 Bacterial protein of unknown function (DUF885) - - - 3.088e-199 642.0
HKD2_k127_6496267_90 TIGRFAM TIGR02449 family protein K09892 - - 0.0000000002317 70.0
HKD2_k127_6496267_91 Domain of unknown function (DUF4440) - - - 0.0000000009447 65.0
HKD2_k127_6496267_92 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000004017 66.0
HKD2_k127_6514170_0 CoA-binding domain protein K09181 - - 9.519e-261 831.0
HKD2_k127_6514170_1 Flavin-binding monooxygenase-like - - - 2.935e-229 725.0
HKD2_k127_6514170_10 Histidine kinase - - - 0.0000000000000000000000001516 111.0
HKD2_k127_6514170_2 amino acid peptide transporter K03305,K06218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 578.0
HKD2_k127_6514170_3 P-aminobenzoate N-oxygenase AurF - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 471.0
HKD2_k127_6514170_4 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 411.0
HKD2_k127_6514170_5 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006068 405.0
HKD2_k127_6514170_6 histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 373.0
HKD2_k127_6514170_7 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000001882 273.0
HKD2_k127_6514170_8 COG2207 AraC-type DNA-binding domain-containing proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004011 276.0
HKD2_k127_6514170_9 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003939 255.0
HKD2_k127_6562286_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1143.0
HKD2_k127_6562286_1 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005883 501.0
HKD2_k127_6562286_10 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000001345 162.0
HKD2_k127_6562286_11 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.00000000000000000000000000000000000008684 152.0
HKD2_k127_6562286_12 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000002632 115.0
HKD2_k127_6562286_13 COG0209 Ribonucleotide reductase, alpha subunit - - - 0.000000000000000000000005537 103.0
HKD2_k127_6562286_14 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000001569 98.0
HKD2_k127_6562286_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 447.0
HKD2_k127_6562286_3 Belongs to the peptidase S1C family K04771,K04772 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 449.0
HKD2_k127_6562286_4 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 381.0
HKD2_k127_6562286_5 NAD-dependent epimerase dehydratase K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 315.0
HKD2_k127_6562286_6 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 298.0
HKD2_k127_6562286_7 Putative aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000132 295.0
HKD2_k127_6562286_8 COG0209 Ribonucleotide reductase, alpha subunit - - - 0.000000000000000000000000000000000000000000000000000000001566 215.0
HKD2_k127_6562286_9 Glutamyl-tRNA amidotransferase K09117 - - 0.000000000000000000000000000000000000000000000004722 179.0
HKD2_k127_6574722_0 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 438.0
HKD2_k127_6574722_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000001134 117.0
HKD2_k127_6615791_0 response regulator receiver K13041 - - 0.000000000000000000000000000000000504 136.0
HKD2_k127_6640243_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1082.0
HKD2_k127_6640243_1 Biotin-lipoyl like K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 335.0
HKD2_k127_6640243_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 318.0
HKD2_k127_6656358_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K12256 - 2.6.1.113 2.173e-207 655.0
HKD2_k127_6656358_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072,K11076 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004797 541.0
HKD2_k127_6656358_2 Required for the activity of the bacterial periplasmic transport system of putrescine K02055,K11069,K11073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 510.0
HKD2_k127_6656358_3 Required for the activity of the bacterial periplasmic transport system of putrescine K02055,K11069,K11073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 492.0
HKD2_k127_6656358_4 Binding-protein-dependent transport system inner membrane component K11071,K11075 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 423.0
HKD2_k127_6656358_5 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 371.0
HKD2_k127_6656358_6 COG1177 ABC-type spermidine putrescine transport system, permease component II K11074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001563 256.0
HKD2_k127_6656908_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 421.0
HKD2_k127_6656908_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 372.0
HKD2_k127_6656908_2 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 295.0
HKD2_k127_6656908_3 COG3170 Tfp pilus assembly protein FimV K08086 - - 0.0000000000001293 75.0
HKD2_k127_6690322_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.269e-306 949.0
HKD2_k127_6690322_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 2.952e-252 780.0
HKD2_k127_6690322_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001263 270.0
HKD2_k127_6690322_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001673 267.0
HKD2_k127_6690322_12 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000001606 249.0
HKD2_k127_6690322_13 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000007872 240.0
HKD2_k127_6690322_14 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000004732 220.0
HKD2_k127_6690322_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000004123 172.0
HKD2_k127_6690322_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000000001765 155.0
HKD2_k127_6690322_17 PFAM Preprotein translocase SecG subunit K03075 - - 0.0000000000000000000000002731 111.0
HKD2_k127_6690322_18 CRS1_YhbY K07574 - - 0.0000000000000000000000002923 111.0
HKD2_k127_6690322_2 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 3.395e-248 791.0
HKD2_k127_6690322_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 3.57e-211 663.0
HKD2_k127_6690322_4 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 529.0
HKD2_k127_6690322_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 470.0
HKD2_k127_6690322_6 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 317.0
HKD2_k127_6690322_7 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009189 307.0
HKD2_k127_6690322_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 310.0
HKD2_k127_6690322_9 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 291.0
HKD2_k127_6696659_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1109.0
HKD2_k127_6696659_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 8.386e-225 725.0
HKD2_k127_6696659_10 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 340.0
HKD2_k127_6696659_11 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 325.0
HKD2_k127_6696659_12 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 324.0
HKD2_k127_6696659_13 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 312.0
HKD2_k127_6696659_14 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 289.0
HKD2_k127_6696659_15 glutathione s-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 285.0
HKD2_k127_6696659_16 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000801 266.0
HKD2_k127_6696659_17 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000002323 252.0
HKD2_k127_6696659_18 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000000005664 244.0
HKD2_k127_6696659_19 PFAM MotA TolQ ExbB proton channel K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000001189 232.0
HKD2_k127_6696659_2 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009799 574.0
HKD2_k127_6696659_20 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000001748 230.0
HKD2_k127_6696659_21 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000001843 222.0
HKD2_k127_6696659_22 Low molecular weight phosphotyrosine protein phosphatase K01104 GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 0.000000000000000000000000000000000000000000000000000001048 196.0
HKD2_k127_6696659_23 CYTH K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000004964 177.0
HKD2_k127_6696659_24 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000008054 177.0
HKD2_k127_6696659_25 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000002203 178.0
HKD2_k127_6696659_26 PFAM translation initiation factor SUI1 K03113 - - 0.0000000000000000000000000000000009417 139.0
HKD2_k127_6696659_27 lipid-A-disaccharide synthase activity - - - 0.00000000000000000000000000000002206 134.0
HKD2_k127_6696659_28 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000003521 129.0
HKD2_k127_6696659_29 Biopolymer transport protein ExbD/TolR K03559 - - 0.000000000000000000000000000001453 126.0
HKD2_k127_6696659_3 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 464.0
HKD2_k127_6696659_30 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000116 110.0
HKD2_k127_6696659_31 Belongs to the UPF0434 family K09791 - - 0.000000000000000000000682 96.0
HKD2_k127_6696659_32 Diguanylate cyclase - - - 0.000000000000000297 89.0
HKD2_k127_6696659_33 Domain of unknown function (DUF4845) - - - 0.00000000002074 73.0
HKD2_k127_6696659_34 - - - - 0.0000000004471 73.0
HKD2_k127_6696659_4 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 444.0
HKD2_k127_6696659_5 Competence protein ComEC Rec2 K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 443.0
HKD2_k127_6696659_6 Lipoprotein releasing system transmembrane protein K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 419.0
HKD2_k127_6696659_7 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 391.0
HKD2_k127_6696659_8 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 359.0
HKD2_k127_6696659_9 Repeat of Unknown Function (DUF347) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 354.0
HKD2_k127_6774942_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.277e-258 806.0
HKD2_k127_6774942_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 503.0
HKD2_k127_6774942_2 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009117 436.0
HKD2_k127_6775432_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1245.0
HKD2_k127_6775432_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 7.304e-270 842.0
HKD2_k127_6775432_10 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000001366 261.0
HKD2_k127_6775432_11 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000158 250.0
HKD2_k127_6775432_12 HAD-superfamily hydrolase, subfamily IA, variant 1 K22292 - 3.1.3.105 0.00000000000000000000000000000000000000000000000000000000000000000001954 246.0
HKD2_k127_6775432_13 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000001112 238.0
HKD2_k127_6775432_14 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000001104 190.0
HKD2_k127_6775432_15 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000005088 136.0
HKD2_k127_6775432_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 538.0
HKD2_k127_6775432_3 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 509.0
HKD2_k127_6775432_4 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 516.0
HKD2_k127_6775432_5 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007774 492.0
HKD2_k127_6775432_6 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 439.0
HKD2_k127_6775432_7 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 419.0
HKD2_k127_6775432_8 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 302.0
HKD2_k127_6775432_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009122 272.0
HKD2_k127_6825584_0 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 550.0
HKD2_k127_6825584_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0006457,GO:0008150,GO:0009987 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 507.0
HKD2_k127_6825584_2 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 499.0
HKD2_k127_6825584_3 Carbamoyl-phosphate synthetase ammonia chain K01955 GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 435.0
HKD2_k127_6825584_4 Dihydrodipicolinate reductase, C-terminus K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003547 272.0
HKD2_k127_6833514_0 Ferrous iron transport protein B C terminus K04759 - - 2.338e-255 801.0
HKD2_k127_6833514_1 ABC transporter K15738 - - 2.062e-196 631.0
HKD2_k127_6833514_10 PFAM FeoA family protein K04758 - - 0.00000000000006797 76.0
HKD2_k127_6833514_11 cytochrome - - - 0.00002136 52.0
HKD2_k127_6833514_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 496.0
HKD2_k127_6833514_3 formate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 499.0
HKD2_k127_6833514_4 NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 464.0
HKD2_k127_6833514_5 4Fe-4S binding domain K08358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 332.0
HKD2_k127_6833514_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 314.0
HKD2_k127_6833514_7 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K04013,K15876 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009923 247.0
HKD2_k127_6833514_8 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000007624 158.0
HKD2_k127_6833514_9 Protease prsW family - - - 0.0000000000000001529 83.0
HKD2_k127_6839674_0 ERAP1-like C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 532.0
HKD2_k127_6861056_0 silver ion transport K07787 - - 0.0 1354.0
HKD2_k127_6861056_1 Isocitrate dehydrogenase - - - 6.273e-223 698.0
HKD2_k127_6861056_10 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000001256 224.0
HKD2_k127_6861056_11 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000001086 182.0
HKD2_k127_6861056_12 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.000000000000000000000000000001436 124.0
HKD2_k127_6861056_13 Domain of unknown function (DUF4266) - - - 0.000000000000000001753 94.0
HKD2_k127_6861056_2 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004721,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009987,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 559.0
HKD2_k127_6861056_3 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006987 543.0
HKD2_k127_6861056_4 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 447.0
HKD2_k127_6861056_5 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 322.0
HKD2_k127_6861056_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 316.0
HKD2_k127_6861056_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 312.0
HKD2_k127_6861056_8 COG3103 SH3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000141 229.0
HKD2_k127_6861056_9 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000006475 226.0
HKD2_k127_6876280_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.629e-308 968.0
HKD2_k127_6876280_1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 1.162e-274 862.0
HKD2_k127_6876280_10 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 444.0
HKD2_k127_6876280_11 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 439.0
HKD2_k127_6876280_12 AMP-binding enzyme C-terminal domain K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 436.0
HKD2_k127_6876280_13 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 432.0
HKD2_k127_6876280_14 Dehydrogenase E1 component K21416 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 416.0
HKD2_k127_6876280_15 phosphoglycerate mutase activity K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 371.0
HKD2_k127_6876280_16 KR domain K13774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 368.0
HKD2_k127_6876280_17 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 335.0
HKD2_k127_6876280_18 COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000642 325.0
HKD2_k127_6876280_19 glutathione s-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 319.0
HKD2_k127_6876280_2 Ring hydroxylating alpha subunit (catalytic domain) - - - 5.69e-212 668.0
HKD2_k127_6876280_20 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 299.0
HKD2_k127_6876280_21 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 292.0
HKD2_k127_6876280_22 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 297.0
HKD2_k127_6876280_23 KR domain K05296 - 1.1.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009677 274.0
HKD2_k127_6876280_24 Phenazine biosynthesis-like protein K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000009574 244.0
HKD2_k127_6876280_25 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000001718 238.0
HKD2_k127_6876280_26 Glycosyltransferase, group 2 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000001089 230.0
HKD2_k127_6876280_27 Nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000000008243 179.0
HKD2_k127_6876280_28 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000003965 160.0
HKD2_k127_6876280_29 hydroperoxide reductase activity - - - 0.000000000000000000000000000000000001919 152.0
HKD2_k127_6876280_3 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 595.0
HKD2_k127_6876280_30 Choline/ethanolamine kinase - - - 0.00000000000000000000000001538 121.0
HKD2_k127_6876280_31 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000009198 109.0
HKD2_k127_6876280_32 glutamate dehydrogenase K15371 - 1.4.1.2 0.00000000000000000002584 98.0
HKD2_k127_6876280_33 Rieske-like [2Fe-2S] domain - - - 0.0000000000000000003696 91.0
HKD2_k127_6876280_34 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000009859 94.0
HKD2_k127_6876280_35 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.000000000000002137 81.0
HKD2_k127_6876280_36 YKOF-related Family - - - 0.00000000000003192 83.0
HKD2_k127_6876280_37 SnoaL-like domain - - - 0.000001588 60.0
HKD2_k127_6876280_4 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 598.0
HKD2_k127_6876280_5 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 562.0
HKD2_k127_6876280_6 TonB-dependent receptor plug K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008183 562.0
HKD2_k127_6876280_7 cytochrome p450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 500.0
HKD2_k127_6876280_8 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 497.0
HKD2_k127_6876280_9 Transketolase, C-terminal domain K21417 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 471.0
HKD2_k127_6877850_0 Outer Membrane Lipoprotein - GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190 - 0.00000000000000000000000000000000000000000000000000001048 198.0
HKD2_k127_6877850_1 - - - - 0.0000000000000000000000000003467 115.0
HKD2_k127_6877850_2 - - - - 0.0000000000000001617 80.0
HKD2_k127_690608_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1182.0
HKD2_k127_690608_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 534.0
HKD2_k127_690608_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000001525 117.0
HKD2_k127_690608_3 Modulates RecA activity K03565 - - 0.000000000000000000000000001944 121.0
HKD2_k127_6933224_0 PFAM Acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 5.006e-215 676.0
HKD2_k127_6933224_1 Malic enzyme K00029 - 1.1.1.40 0.000000000000000000000000000000000000000000000000000000000001263 211.0
HKD2_k127_7054569_0 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000003266 199.0
HKD2_k127_7054569_1 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016740,GO:0017013,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0031975,GO:0036094,GO:0036211,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098567,GO:1901265,GO:1901363,GO:1901564 2.7.1.180 0.0000000000000000000000000000000000000002654 154.0
HKD2_k127_7054569_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000009142 138.0
HKD2_k127_7054569_3 Phosphoglycerate mutase family - - - 0.000000000000005434 84.0
HKD2_k127_711210_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 563.0
HKD2_k127_711210_1 Belongs to the skp family K06142 - - 0.000000001047 66.0
HKD2_k127_7139424_0 HypF finger - - - 6.346e-257 815.0
HKD2_k127_7139424_1 Hydrogenase formation hypA family K04654 GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008458 572.0
HKD2_k127_7139424_10 - - - - 0.000000002779 62.0
HKD2_k127_7139424_2 AIR synthase related protein, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 445.0
HKD2_k127_7139424_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 397.0
HKD2_k127_7139424_4 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 332.0
HKD2_k127_7139424_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000000001627 166.0
HKD2_k127_7139424_6 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000000799 145.0
HKD2_k127_7139424_7 - - - - 0.000000000000000000000000000000001645 132.0
HKD2_k127_7139424_8 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.00000000000000000000000009215 117.0
HKD2_k127_7139424_9 SnoaL-like domain - - - 0.000000000000000000000003887 106.0
HKD2_k127_7172959_0 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007108 486.0
HKD2_k127_7172959_1 Putative MetA-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000005434 193.0
HKD2_k127_7172959_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000006428 163.0
HKD2_k127_7172959_3 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.0000000000000000000000000000000000009591 144.0
HKD2_k127_7293598_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00244 - 1.3.5.4 4.2e-322 998.0
HKD2_k127_7293598_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 2.724e-227 713.0
HKD2_k127_7293598_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004323 311.0
HKD2_k127_7293598_11 Belongs to the UPF0502 family K09915 - - 0.000000000000000000000000000000000000000000000000000000000000000004564 246.0
HKD2_k127_7293598_12 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000003245 242.0
HKD2_k127_7293598_13 SMART PDZ DHR GLGF domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000007224 228.0
HKD2_k127_7293598_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000173 220.0
HKD2_k127_7293598_15 Cytochrome c - - - 0.000000000000000000000000000000000000000000000002911 179.0
HKD2_k127_7293598_16 NADH dehydrogenase (ubiquinone) activity K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000000000000000000000000000000000000000000002094 170.0
HKD2_k127_7293598_17 pyridoxamine 5-phosphate - - - 0.0000000000000000000000000000000001305 138.0
HKD2_k127_7293598_2 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 3.055e-212 689.0
HKD2_k127_7293598_3 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 4.802e-195 624.0
HKD2_k127_7293598_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004126 502.0
HKD2_k127_7293598_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 454.0
HKD2_k127_7293598_6 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 418.0
HKD2_k127_7293598_7 2Fe-2S iron-sulfur cluster binding domain K00245 - 1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 376.0
HKD2_k127_7293598_8 fumarate reductase respiratory complex transmembrane subunit K00246 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 317.0
HKD2_k127_7293598_9 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 316.0
HKD2_k127_7387081_0 Dak2 K07030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 495.0
HKD2_k127_7387081_1 Peptidoglycan-binding domain 1 protein K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 466.0
HKD2_k127_7387081_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 338.0
HKD2_k127_7387081_3 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 301.0
HKD2_k127_7387081_4 Type II secretion system protein B - - - 0.000000000003065 76.0
HKD2_k127_7613547_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 2.464e-231 749.0
HKD2_k127_7613547_1 PFAM Alcohol dehydrogenase zinc-binding domain protein K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003544 482.0
HKD2_k127_7613547_2 PFAM Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006032 392.0
HKD2_k127_7613547_3 PFAM NUDIX hydrolase - - - 0.00000000000000000000000000000000000008935 162.0
HKD2_k127_7613547_4 TonB-dependent receptor K02014 - - 0.00000000000001733 78.0
HKD2_k127_7669600_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 402.0
HKD2_k127_7669600_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 379.0
HKD2_k127_7675911_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.06e-293 929.0
HKD2_k127_7675911_1 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 7.118e-243 780.0
HKD2_k127_7675911_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.912e-218 694.0
HKD2_k127_7675911_3 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006937 466.0
HKD2_k127_7675911_4 TIGRFAM ABC exporter ATP-binding subunit, DevA family K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 388.0
HKD2_k127_7675911_5 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 342.0
HKD2_k127_7675911_6 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000003895 253.0
HKD2_k127_7675911_7 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000001098 234.0
HKD2_k127_7675911_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000008654 237.0
HKD2_k127_7675911_9 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 0.0000000000000203 83.0
HKD2_k127_7678065_0 LssY C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 511.0
HKD2_k127_7678065_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000133 243.0
HKD2_k127_7678065_2 Cardiolipin synthase K06132 - - 0.000000000000000000000004087 115.0
HKD2_k127_7678065_3 transcriptional regulator, AraC family - - - 0.0000000000000000008187 99.0
HKD2_k127_7678065_4 Trimethylamine methyltransferase (MTTB) - - - 0.000000000000000001078 85.0
HKD2_k127_7678065_5 - - - - 0.0000000002872 68.0
HKD2_k127_7724095_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 7.183e-291 905.0
HKD2_k127_7724095_1 PQQ-dependent polyvinyl alcohol dehydrogenase - - - 1.135e-208 666.0
HKD2_k127_7724095_10 proline dipeptidase activity - - - 0.000000000000000005811 97.0
HKD2_k127_7724095_11 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000004075 91.0
HKD2_k127_7724095_12 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000002413 72.0
HKD2_k127_7724095_13 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.000000000005696 70.0
HKD2_k127_7724095_14 RHS Repeat - - - 0.000001397 61.0
HKD2_k127_7724095_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 5.447e-207 653.0
HKD2_k127_7724095_3 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007572 562.0
HKD2_k127_7724095_4 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000866 490.0
HKD2_k127_7724095_5 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 469.0
HKD2_k127_7724095_6 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 396.0
HKD2_k127_7724095_7 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000002607 234.0
HKD2_k127_7724095_8 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000003204 187.0
HKD2_k127_7724095_9 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000000000001717 127.0
HKD2_k127_7736688_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 3.2e-282 877.0
HKD2_k127_7736688_1 TIGRFAM malate synthase A K01638 - 2.3.3.9 1.246e-261 813.0
HKD2_k127_7736688_2 Biotin-lipoyl like K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 474.0
HKD2_k127_7736688_3 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 441.0
HKD2_k127_7736688_4 Bacterial transcriptional repressor C-terminal K09017 - - 0.0000000000000000000000000000000000000000000000000000009449 199.0
HKD2_k127_7759510_0 ABC transporter K15738 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - 1.275e-261 818.0
HKD2_k127_7759510_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002065 248.0
HKD2_k127_7773386_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 1.837e-290 902.0
HKD2_k127_7773386_1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 4.742e-268 837.0
HKD2_k127_7773386_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000002278 108.0
HKD2_k127_7773386_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 501.0
HKD2_k127_7773386_3 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 486.0
HKD2_k127_7773386_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009298 485.0
HKD2_k127_7773386_5 CoA-transferase family III K01796 - 5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 461.0
HKD2_k127_7773386_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K02573 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008196 334.0
HKD2_k127_7773386_7 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000000119 146.0
HKD2_k127_7773386_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000007597 131.0
HKD2_k127_7773386_9 cyclic nucleotide binding K10914 - - 0.00000000000000000000000000209 117.0
HKD2_k127_7780626_0 TIGRFAM penicillin-binding protein, 1A K05366 - 2.4.1.129,3.4.16.4 2.351e-232 746.0
HKD2_k127_7780626_1 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 1.627e-220 694.0
HKD2_k127_7780626_10 Pilus assembly protein, PilO K02664 - - 0.00000000000000000000000000000000000000000000000000000000001022 215.0
HKD2_k127_7780626_11 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000000000000000000000000377 198.0
HKD2_k127_7780626_12 - - - - 0.0000000000000000000000000000000000000000000000001997 183.0
HKD2_k127_7780626_13 COG3166 Tfp pilus assembly protein PilN K02663 - - 0.0000000000000000000000000000000000000000000006277 172.0
HKD2_k127_7780626_14 pilus assembly protein pilp K02665 - - 0.0000000000000000000000000000000000000001441 164.0
HKD2_k127_7780626_15 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000001004 147.0
HKD2_k127_7780626_16 Binds the 23S rRNA K02909 - - 0.000000000000000000000000000001001 121.0
HKD2_k127_7780626_2 Type II secretory pathway, component HofQ K02666 - - 5.215e-202 652.0
HKD2_k127_7780626_3 Belongs to the citrate synthase family K01647 - 2.3.3.1 9.631e-198 624.0
HKD2_k127_7780626_4 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 516.0
HKD2_k127_7780626_5 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009275 452.0
HKD2_k127_7780626_6 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 434.0
HKD2_k127_7780626_7 Zn-dependent protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 435.0
HKD2_k127_7780626_8 Pilus assembly protein K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 364.0
HKD2_k127_7780626_9 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000001766 244.0
HKD2_k127_7786866_0 Glutamine amidotransferases class-II K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 537.0
HKD2_k127_7786866_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 516.0
HKD2_k127_7786866_2 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006061 404.0
HKD2_k127_7786866_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000003428 75.0
HKD2_k127_7806853_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 4.889e-208 649.0
HKD2_k127_7806853_1 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00127,K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000004362 254.0
HKD2_k127_7806853_2 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000001387 228.0
HKD2_k127_7839252_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1239.0
HKD2_k127_7839252_1 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 0.0 1022.0
HKD2_k127_7839252_10 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 2.101e-199 629.0
HKD2_k127_7839252_11 geranylgeranyl reductase activity K00313 - - 3.753e-198 627.0
HKD2_k127_7839252_12 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 641.0
HKD2_k127_7839252_13 Outer membrane receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 625.0
HKD2_k127_7839252_14 COG0183 Acetyl-CoA acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 590.0
HKD2_k127_7839252_15 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 589.0
HKD2_k127_7839252_16 Acetyl-CoA acetyltransferase K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 585.0
HKD2_k127_7839252_17 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 578.0
HKD2_k127_7839252_18 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 579.0
HKD2_k127_7839252_19 COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 577.0
HKD2_k127_7839252_2 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 2.5e-323 1033.0
HKD2_k127_7839252_20 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005693 560.0
HKD2_k127_7839252_21 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 552.0
HKD2_k127_7839252_22 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 532.0
HKD2_k127_7839252_23 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 460.0
HKD2_k127_7839252_24 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003369 477.0
HKD2_k127_7839252_25 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 442.0
HKD2_k127_7839252_26 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 438.0
HKD2_k127_7839252_27 saccharopine dehydrogenase activity K00290 - 1.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 443.0
HKD2_k127_7839252_28 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 418.0
HKD2_k127_7839252_29 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 407.0
HKD2_k127_7839252_3 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 4.16e-312 976.0
HKD2_k127_7839252_30 Enoyl-CoA hydratase/isomerase K01661,K07536 - 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 398.0
HKD2_k127_7839252_31 Dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 388.0
HKD2_k127_7839252_32 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 355.0
HKD2_k127_7839252_33 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 362.0
HKD2_k127_7839252_34 Electron transfer flavoprotein alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 351.0
HKD2_k127_7839252_35 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 324.0
HKD2_k127_7839252_36 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 316.0
HKD2_k127_7839252_37 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 315.0
HKD2_k127_7839252_38 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 322.0
HKD2_k127_7839252_39 NAD dependent epimerase/dehydratase family K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 304.0
HKD2_k127_7839252_4 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 4.598e-242 764.0
HKD2_k127_7839252_40 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 302.0
HKD2_k127_7839252_41 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 293.0
HKD2_k127_7839252_42 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 293.0
HKD2_k127_7839252_43 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 285.0
HKD2_k127_7839252_44 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001338 284.0
HKD2_k127_7839252_45 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004773 274.0
HKD2_k127_7839252_46 Belongs to the pseudouridine synthase RsuA family K06181 - 5.4.99.20 0.00000000000000000000000000000000000000000000000000000000000000000000004857 252.0
HKD2_k127_7839252_47 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000001164 249.0
HKD2_k127_7839252_48 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000001921 237.0
HKD2_k127_7839252_49 N-terminal half of MaoC dehydratase K09709 - 4.2.1.153 0.0000000000000000000000000000000000000000000000000000000000001285 215.0
HKD2_k127_7839252_5 Malate synthase K01638 - 2.3.3.9 1.081e-238 750.0
HKD2_k127_7839252_50 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000004476 213.0
HKD2_k127_7839252_51 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000000000006122 203.0
HKD2_k127_7839252_52 - - - - 0.000000000000000000000000000000000000000000000000000001212 199.0
HKD2_k127_7839252_53 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000007934 190.0
HKD2_k127_7839252_54 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.000000000000000000000000000000000000000000000000001913 187.0
HKD2_k127_7839252_55 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000485 188.0
HKD2_k127_7839252_56 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000001045 181.0
HKD2_k127_7839252_57 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000007678 185.0
HKD2_k127_7839252_58 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity - - - 0.00000000000000000000000000000000000000000002835 165.0
HKD2_k127_7839252_59 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000000000000000001426 167.0
HKD2_k127_7839252_6 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K02182 GO:0003674,GO:0003824,GO:0016405,GO:0016874,GO:0016877,GO:0016879,GO:0016881,GO:0051108,GO:0051109 6.2.1.48 4.51e-237 744.0
HKD2_k127_7839252_60 electron transfer flavoprotein-ubiquinone oxidoreductase - - - 0.000000000000000000000000000000000000000003273 161.0
HKD2_k127_7839252_61 EthD domain - - - 0.000000000000000000000000000000000000000009396 162.0
HKD2_k127_7839252_62 Rubredoxin-like zinc ribbon domain (DUF35_N) - - - 0.000000000000000000000000000000005867 145.0
HKD2_k127_7839252_63 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000000001134 130.0
HKD2_k127_7839252_64 Cytochrome c - - - 0.00000000000000000000000007456 111.0
HKD2_k127_7839252_65 protein acetylation - - - 0.00000000000000000000004579 105.0
HKD2_k127_7839252_66 Mycofactocin system - - - 0.0000000000000000001416 92.0
HKD2_k127_7839252_67 - - - - 0.000000001551 61.0
HKD2_k127_7839252_7 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 4.538e-237 737.0
HKD2_k127_7839252_8 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 1.127e-219 690.0
HKD2_k127_7839252_9 Aldehyde dehydrogenase family K00128 - 1.2.1.3 5.771e-202 663.0
HKD2_k127_7903244_0 Sulfatase K01130 - 3.1.6.1 0.0 1226.0
HKD2_k127_7903244_1 COG0183 Acetyl-CoA acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 582.0
HKD2_k127_7903244_10 Alpha beta hydrolase K14731 - 3.1.1.83 0.00000000000000000000000000000000000000000000000000000000000002759 226.0
HKD2_k127_7903244_11 transcriptional regulator K04033 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009438,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019172,GO:0019243,GO:0019249,GO:0019438,GO:0019752,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042180,GO:0042182,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0046483,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901617 - 0.000000000000000000000002512 114.0
HKD2_k127_7903244_2 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 575.0
HKD2_k127_7903244_3 COG1960 Acyl-CoA dehydrogenases K18244 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 565.0
HKD2_k127_7903244_4 COG1012 NAD-dependent aldehyde dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 495.0
HKD2_k127_7903244_5 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008933 414.0
HKD2_k127_7903244_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 353.0
HKD2_k127_7903244_7 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006374 330.0
HKD2_k127_7903244_8 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 330.0
HKD2_k127_7903244_9 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 301.0
HKD2_k127_79035_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 7.7e-321 1004.0
HKD2_k127_79035_1 PFAM peptidase M3A and M3B, thimet oligopeptidase F K01414 - 3.4.24.70 7.949e-263 825.0
HKD2_k127_79035_10 serine protease protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 412.0
HKD2_k127_79035_11 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 377.0
HKD2_k127_79035_12 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 361.0
HKD2_k127_79035_13 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 357.0
HKD2_k127_79035_14 PFAM DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 328.0
HKD2_k127_79035_15 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 316.0
HKD2_k127_79035_16 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 308.0
HKD2_k127_79035_17 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.266 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008761 292.0
HKD2_k127_79035_18 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 291.0
HKD2_k127_79035_19 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000118 271.0
HKD2_k127_79035_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 3.409e-254 795.0
HKD2_k127_79035_20 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000009845 257.0
HKD2_k127_79035_21 PFAM Peptidoglycan-binding lysin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001108 255.0
HKD2_k127_79035_22 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000247 251.0
HKD2_k127_79035_23 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000001062 238.0
HKD2_k127_79035_24 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000055 237.0
HKD2_k127_79035_25 PFAM cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000003558 209.0
HKD2_k127_79035_26 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000001593 207.0
HKD2_k127_79035_27 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000004834 205.0
HKD2_k127_79035_28 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000005277 194.0
HKD2_k127_79035_29 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000007559 197.0
HKD2_k127_79035_3 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 606.0
HKD2_k127_79035_30 E3 Ubiquitin ligase - - - 0.0000000000000000000000000000000000000000000000000006322 196.0
HKD2_k127_79035_31 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000000009479 182.0
HKD2_k127_79035_32 Belongs to the Smg family K03747 - - 0.00000000000000000000000000000000000000000004773 168.0
HKD2_k127_79035_33 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.0000000000000000000000000000000000000001402 166.0
HKD2_k127_79035_34 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000007059 150.0
HKD2_k127_79035_35 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000001655 143.0
HKD2_k127_79035_36 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.0000000000000000000000000001075 123.0
HKD2_k127_79035_37 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000002229 122.0
HKD2_k127_79035_38 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000277 115.0
HKD2_k127_79035_39 OmpA-like transmembrane domain - - - 0.00000000000000000000009675 106.0
HKD2_k127_79035_4 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 531.0
HKD2_k127_79035_40 OmpA-like transmembrane domain - - - 0.000000000000000000000565 102.0
HKD2_k127_79035_41 AntiSigma factor - - - 0.0000000000002391 80.0
HKD2_k127_79035_42 Domain of unknown function (DUF4136) - - - 0.0000000000004035 77.0
HKD2_k127_79035_43 general secretion pathway protein - - - 0.00000001716 58.0
HKD2_k127_79035_5 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 491.0
HKD2_k127_79035_6 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 466.0
HKD2_k127_79035_7 response regulator receiver K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 438.0
HKD2_k127_79035_8 Anthranilate synthase component I, N terminal region K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008956 410.0
HKD2_k127_79035_9 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 397.0
HKD2_k127_7926387_0 COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 497.0
HKD2_k127_7926387_1 hydrolase activity, acting on ester bonds K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 302.0
HKD2_k127_7926387_2 isochorismatase - - - 0.00000000000000000000000000000000000000000000000000000000000000004387 229.0
HKD2_k127_7926387_3 - - - - 0.00000000000000000000000000000005986 136.0
HKD2_k127_7962734_0 acyl-CoA dehydrogenase K00248 - 1.3.8.1 1.94e-229 719.0
HKD2_k127_7962734_1 AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 619.0
HKD2_k127_7962734_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000001083 156.0
HKD2_k127_7962734_11 Flavin reductase like domain - - - 0.0000000000000000000000000000000002451 143.0
HKD2_k127_7962734_12 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000002143 136.0
HKD2_k127_7962734_13 LysR substrate binding domain - - - 0.000000000000000000005158 105.0
HKD2_k127_7962734_2 PQQ-like domain K05889 - 1.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000752 600.0
HKD2_k127_7962734_3 IgA Peptidase M64 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008742 578.0
HKD2_k127_7962734_4 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 437.0
HKD2_k127_7962734_5 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009674 345.0
HKD2_k127_7962734_6 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000707 306.0
HKD2_k127_7962734_7 Putative 2OG-Fe(II) oxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 315.0
HKD2_k127_7962734_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007263 264.0
HKD2_k127_7962734_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000007698 168.0
HKD2_k127_7982594_0 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 398.0
HKD2_k127_7982594_1 PFAM Alcohol dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 330.0
HKD2_k127_7998109_0 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00244 - 1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 482.0
HKD2_k127_7998109_1 enzyme related to lactoylglutathione lyase K06996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 324.0
HKD2_k127_7998109_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002859 260.0
HKD2_k127_7998109_3 AcnD-accessory protein PrpF - - - 0.000000000000000000000000000000000000000000000000000000000000000005506 231.0
HKD2_k127_7998109_4 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000000000001505 227.0
HKD2_k127_7998109_5 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000001606 201.0
HKD2_k127_7998109_6 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000009212 172.0
HKD2_k127_7998109_7 denitrification pathway - - - 0.00000000000001501 79.0
HKD2_k127_8008678_0 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 358.0
HKD2_k127_8008678_1 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009203 341.0
HKD2_k127_8008678_2 formate C-acetyltransferase glycine radical K00656 - 2.3.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 308.0
HKD2_k127_8067591_0 cytochrome - - - 0.000000000000000000000000000000000000000000004175 170.0
HKD2_k127_8067591_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000002828 137.0
HKD2_k127_8067591_2 Protein of unknown function (DUF541) - - - 0.0000000000000000000000000001031 124.0
HKD2_k127_8259699_0 His Kinase A (phosphoacceptor) domain - - - 1.271e-239 772.0
HKD2_k127_8259699_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 397.0
HKD2_k127_8259699_2 Transcriptional regulatory protein, C terminal K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007438 296.0
HKD2_k127_8259699_3 NnrU protein K21310 - 2.1.1.334 0.0000000000000000000000000000000000000000000000000000000000000000000000000003462 269.0
HKD2_k127_8259699_4 Uncharacterized ACR, COG1993 - - - 0.000000000000000000000000000000000000000002105 157.0
HKD2_k127_8259699_5 COG0477 Permeases of the major facilitator superfamily K07552 - - 0.00000000000000000000000005671 112.0
HKD2_k127_8311847_0 TonB dependent receptor K02014 - - 3.329e-299 950.0
HKD2_k127_8311847_1 trimethylamine methyltransferase K14083 - 2.1.1.250 1.793e-215 677.0
HKD2_k127_8311847_2 ATPases associated with a variety of cellular activities K02000 - 3.6.3.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 306.0
HKD2_k127_8369154_0 Belongs to the GcvT family K00315 - 1.5.8.4 0.0 1294.0
HKD2_k127_8369154_1 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 1.104e-214 680.0
HKD2_k127_8369154_10 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000007367 230.0
HKD2_k127_8369154_11 MarC family integral membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000005881 194.0
HKD2_k127_8369154_12 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000006459 198.0
HKD2_k127_8369154_13 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000004092 181.0
HKD2_k127_8369154_14 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000001054 163.0
HKD2_k127_8369154_15 Phospholipid methyltransferase - - - 0.00000000000000000000001007 108.0
HKD2_k127_8369154_16 - - - - 0.000000000004024 79.0
HKD2_k127_8369154_17 Cytochrome c K00406 - - 0.0000000004952 65.0
HKD2_k127_8369154_18 - - - - 0.00000004968 57.0
HKD2_k127_8369154_2 Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process K05797 - 1.17.99.1 4.281e-194 618.0
HKD2_k127_8369154_3 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004722 522.0
HKD2_k127_8369154_4 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 512.0
HKD2_k127_8369154_5 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 468.0
HKD2_k127_8369154_6 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 425.0
HKD2_k127_8369154_7 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 376.0
HKD2_k127_8369154_8 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 359.0
HKD2_k127_8369154_9 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 334.0
HKD2_k127_8371338_0 Iron permease FTR1 family K07243 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000133 260.0
HKD2_k127_8371338_1 Cupredoxin-like domain - - - 0.000000000000000000000000000000000004221 139.0
HKD2_k127_8371338_2 LysR substrate binding domain - - - 0.00000000000000000000000002043 114.0
HKD2_k127_8405963_0 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease K03694 - - 0.0 1063.0
HKD2_k127_8405963_1 PFAM Type II secretion system protein E K02454 - - 1.154e-202 645.0
HKD2_k127_8405963_10 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 304.0
HKD2_k127_8405963_11 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000000009463 181.0
HKD2_k127_8405963_12 Cytochrome c assembly protein - - - 0.00000000000000000000000000000000000000000003161 172.0
HKD2_k127_8405963_13 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000003416 166.0
HKD2_k127_8405963_14 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000002229 160.0
HKD2_k127_8405963_15 Type II secretion system protein C - - - 0.00000000000000000000000000000000000192 151.0
HKD2_k127_8405963_16 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000000005084 135.0
HKD2_k127_8405963_17 Belongs to the HSP15 family K04762 - - 0.0000000000000000000000000000012 125.0
HKD2_k127_8405963_18 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.0000000000000000000000000446 108.0
HKD2_k127_8405963_19 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000001515 109.0
HKD2_k127_8405963_2 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 578.0
HKD2_k127_8405963_20 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000003664 64.0
HKD2_k127_8405963_3 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 562.0
HKD2_k127_8405963_4 General Secretion Pathway protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 574.0
HKD2_k127_8405963_5 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 543.0
HKD2_k127_8405963_6 signal peptide peptidase K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 482.0
HKD2_k127_8405963_7 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 471.0
HKD2_k127_8405963_8 General secretion pathway protein F K02455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 418.0
HKD2_k127_8405963_9 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 388.0
HKD2_k127_860661_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1201.0
HKD2_k127_860661_1 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 530.0
HKD2_k127_860661_10 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000009236 146.0
HKD2_k127_860661_11 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 0.000000000000000000000000002764 111.0
HKD2_k127_860661_12 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372 - 0.00000000000000000006552 94.0
HKD2_k127_860661_2 Type II secretion system K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 494.0
HKD2_k127_860661_3 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 448.0
HKD2_k127_860661_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 373.0
HKD2_k127_860661_5 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 374.0
HKD2_k127_860661_6 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000000000000000000000000000000000000000008449 245.0
HKD2_k127_860661_7 Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family K00569 - 2.1.1.67 0.00000000000000000000000000000000000000000000000000000000000003317 222.0
HKD2_k127_860661_8 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.0000000000000000000000000000000000000000000000000000000001398 215.0
HKD2_k127_860661_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000008772 203.0
HKD2_k127_888011_0 Concanavalin A-like lectin/glucanases superfamily - - - 1.081e-305 957.0
HKD2_k127_888011_1 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 3.495e-298 939.0
HKD2_k127_888011_10 PFAM MotA TolQ ExbB proton channel K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000002112 232.0
HKD2_k127_888011_11 COG3103 SH3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000002251 219.0
HKD2_k127_888011_12 - - - - 0.0000000000000000000000000000000000000000000000000000000001017 209.0
HKD2_k127_888011_13 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000000000000000000000000000000004228 184.0
HKD2_k127_888011_14 Glutathione peroxidase - - - 0.000000000000000000000000000001838 128.0
HKD2_k127_888011_15 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000005948 123.0
HKD2_k127_888011_16 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000003429 121.0
HKD2_k127_888011_17 Tetratricopeptide repeat - - - 0.00000000000000001224 99.0
HKD2_k127_888011_18 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000003484 84.0
HKD2_k127_888011_19 - - - - 0.000000000004935 76.0
HKD2_k127_888011_2 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00366,K00381,K00392 GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363 1.7.7.1,1.8.1.2,1.8.7.1 1.851e-258 806.0
HKD2_k127_888011_20 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000001217 63.0
HKD2_k127_888011_3 - - - - 2.039e-227 716.0
HKD2_k127_888011_4 Tetratricopeptide repeat - - - 2.355e-214 706.0
HKD2_k127_888011_5 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component K00380,K14338 - 1.14.14.1,1.6.2.4,1.8.1.2 3.79e-205 655.0
HKD2_k127_888011_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009307 505.0
HKD2_k127_888011_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 447.0
HKD2_k127_888011_8 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 360.0
HKD2_k127_888011_9 Belongs to the PAPS reductase family. CysH subfamily K00390 GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 325.0
HKD2_k127_8953015_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1053.0
HKD2_k127_8953015_1 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000003541 252.0
HKD2_k127_8953015_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0000000000000000000000000000000000000000000000000000006376 196.0
HKD2_k127_8958621_0 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 391.0
HKD2_k127_8958621_1 Heat shock 70 kDa protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 351.0
HKD2_k127_8958621_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000005449 246.0
HKD2_k127_8958621_3 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000001205 213.0
HKD2_k127_8958621_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000008459 160.0
HKD2_k127_8970237_0 Nickel-dependent hydrogenase K05922,K06281 - 1.12.5.1,1.12.99.6 1.101e-299 927.0
HKD2_k127_8970237_1 PFAM Cysteine-rich - - - 9.283e-224 702.0
HKD2_k127_8970237_10 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002201 233.0
HKD2_k127_8970237_11 nitrate reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000007505 222.0
HKD2_k127_8970237_12 SCP-2 sterol transfer family - - - 0.0000000000000000000000000000000000000000000000000000001414 201.0
HKD2_k127_8970237_13 - - - - 0.0000000000000000000000000000000000000000000000000001358 190.0
HKD2_k127_8970237_14 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000000000000000000000000000000000002708 168.0
HKD2_k127_8970237_15 - - - - 0.00000000000000000000000000000000000000001257 164.0
HKD2_k127_8970237_16 Hydrogenase expression formation protein K03605 - - 0.000000000000000000000000000000000000003759 151.0
HKD2_k127_8970237_17 transcriptional - - - 0.00000000000000000000002096 113.0
HKD2_k127_8970237_18 Sulfurtransferase - - - 0.00000000434 70.0
HKD2_k127_8970237_2 Amino acid permease - - - 7.256e-211 675.0
HKD2_k127_8970237_3 Pfam Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 601.0
HKD2_k127_8970237_4 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 522.0
HKD2_k127_8970237_5 Hydrogenase (NiFe) small subunit HydA K05927 - 1.12.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 509.0
HKD2_k127_8970237_6 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000596 511.0
HKD2_k127_8970237_7 Aminotransferase class-V K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004069 446.0
HKD2_k127_8970237_8 4Fe-4S dicluster domain K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000696 389.0
HKD2_k127_8970237_9 Glycine cleavage H-protein K02437 - - 0.000000000000000000000000000000000000000000000000000000000000000004382 228.0
HKD2_k127_8976806_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00436 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 4.143e-255 792.0
HKD2_k127_8976806_1 NADH ubiquinone oxidoreductase 20 kDa subunit K18007 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 340.0
HKD2_k127_8976806_2 PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K18006 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000002547 258.0
HKD2_k127_9000529_0 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 554.0
HKD2_k127_9000529_1 TonB-dependent Receptor Plug K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 383.0
HKD2_k127_9000529_2 Inositol monophosphatase family K05602 - 3.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 315.0
HKD2_k127_9000529_3 PFAM N-acetylmuramoyl-L-alanine amidase family 2 K03806 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000003549 267.0
HKD2_k127_9000529_4 adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000001887 260.0
HKD2_k127_9000529_5 Periplasmic binding protein K02016,K06858 - - 0.00000000000000000000000000000000000000000000000000000000000000005727 239.0
HKD2_k127_9000529_6 Conserved TM helix - - - 0.000000000000000000000000000000000000000000000009363 175.0
HKD2_k127_9000529_7 Membrane protein required for beta-lactamase induction K03807 - - 0.000000000000000000000000000000201 139.0
HKD2_k127_9020347_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1341.0
HKD2_k127_9020347_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.93e-205 646.0
HKD2_k127_9020347_10 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008221 337.0
HKD2_k127_9020347_11 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 338.0
HKD2_k127_9020347_12 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 331.0
HKD2_k127_9020347_13 Oxidoreductase FAD-binding domain K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006643 325.0
HKD2_k127_9020347_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 317.0
HKD2_k127_9020347_15 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 308.0
HKD2_k127_9020347_16 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001735 294.0
HKD2_k127_9020347_17 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005024 270.0
HKD2_k127_9020347_18 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000019 274.0
HKD2_k127_9020347_19 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000009809 283.0
HKD2_k127_9020347_2 Ammonium Transporter K03320 - - 2.205e-203 643.0
HKD2_k127_9020347_20 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001065 267.0
HKD2_k127_9020347_21 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001121 263.0
HKD2_k127_9020347_22 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000003809 258.0
HKD2_k127_9020347_23 Response regulator of the LytR AlgR family K08083 - - 0.000000000000000000000000000000000000000000000000000000000000000000005211 243.0
HKD2_k127_9020347_24 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000804 211.0
HKD2_k127_9020347_25 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000008604 203.0
HKD2_k127_9020347_26 Belongs to the P(II) protein family K04751,K04752 - - 0.0000000000000000000000000000000000000000000000000002037 188.0
HKD2_k127_9020347_27 enzyme of heme biosynthesis K02498 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000006562 196.0
HKD2_k127_9020347_28 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000021 174.0
HKD2_k127_9020347_29 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.00000000000000000000000000000000000002565 162.0
HKD2_k127_9020347_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 1.178e-202 645.0
HKD2_k127_9020347_30 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000007321 136.0
HKD2_k127_9020347_31 Uroporphyrinogen III synthase K01719 - 4.2.1.75 0.0000000000000000000000000000000008155 141.0
HKD2_k127_9020347_32 protein conserved in bacteria K09921 - - 0.0000000000000000000000000000000008668 140.0
HKD2_k127_9020347_33 transcriptional - - - 0.0000000000000000000000000000004859 126.0
HKD2_k127_9020347_34 Sterol-binding domain protein K03690 - - 0.0000000000000000000000002604 114.0
HKD2_k127_9020347_35 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000001915 119.0
HKD2_k127_9020347_36 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.0000000000000000000007092 100.0
HKD2_k127_9020347_37 Protein of unknown function (DUF2892) - - - 0.0000000000000000000009911 102.0
HKD2_k127_9020347_38 enzyme of heme biosynthesis K02496,K13543 - 2.1.1.107,4.2.1.75 0.0000000000000000002375 100.0
HKD2_k127_9020347_39 Membrane fusogenic activity K09806 - - 0.0000000000000000003043 92.0
HKD2_k127_9020347_4 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 612.0
HKD2_k127_9020347_41 Glutathione S-transferase - - - 0.00003153 47.0
HKD2_k127_9020347_5 Fad linked oxidase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006052 515.0
HKD2_k127_9020347_6 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 471.0
HKD2_k127_9020347_7 Anthranilate synthase component I, N terminal region K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 420.0
HKD2_k127_9020347_8 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 365.0
HKD2_k127_9020347_9 Belongs to the 'phage' integrase family. XerC subfamily K03733 GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005974 346.0
HKD2_k127_9037924_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.833e-271 847.0
HKD2_k127_9037924_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 555.0
HKD2_k127_9037924_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000004272 228.0
HKD2_k127_9037924_3 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000000000000000000000006257 178.0
HKD2_k127_9037924_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000000002818 143.0
HKD2_k127_9037924_5 - - - - 0.0000000000000000000000007215 110.0
HKD2_k127_9037924_6 - - - - 0.000000000000000000000001252 110.0
HKD2_k127_9037924_7 - - - - 0.000000000000000000000001426 108.0
HKD2_k127_9037924_8 - - - - 0.000000002106 63.0
HKD2_k127_9078494_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1435.0
HKD2_k127_9078494_1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 4.489e-280 871.0
HKD2_k127_9078494_2 Fructose-bisphosphate aldolase, class II, Calvin cycle subtype K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008242 594.0
HKD2_k127_9078494_3 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925,K19697 - 2.7.2.1,2.7.2.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 372.0
HKD2_k127_9078494_4 Lipid A 3-O-deacylase (PagL) - - - 0.0000004212 61.0
HKD2_k127_9100077_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 5.547e-249 779.0
HKD2_k127_9100077_1 homocysteine K00547 - 2.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 429.0
HKD2_k127_9100077_2 - - - - 0.000000000000000008997 87.0
HKD2_k127_9104423_0 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 510.0
HKD2_k127_9115458_0 Amidohydrolase family - - - 1.354e-194 618.0
HKD2_k127_9115458_1 COG1960 Acyl-CoA dehydrogenases K20035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 617.0
HKD2_k127_9115458_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 438.0
HKD2_k127_9115458_3 fumarylacetoacetate hydrolase K16165 - 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 308.0
HKD2_k127_9115458_4 maleylacetoacetate isomerase K01801 - 5.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000001348 263.0
HKD2_k127_9115458_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000005677 231.0
HKD2_k127_9115458_6 Thioesterase superfamily K19222 - 3.1.2.28 0.000000000000000000000000000000000000000000000000000007798 195.0
HKD2_k127_9115458_7 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000000004236 124.0
HKD2_k127_913455_0 Phosphoglucose isomerase K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 572.0
HKD2_k127_913455_1 PFAM NAD-dependent epimerase dehydratase K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 522.0
HKD2_k127_913455_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.000000000000006727 75.0
HKD2_k127_9199071_0 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 310.0
HKD2_k127_9199071_1 Mur ligase middle domain protein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000001331 261.0
HKD2_k127_9199071_2 Capsular polysaccharide biosynthesis protein CapK K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000009677 197.0
HKD2_k127_9199071_3 COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) - - - 0.0000000000000000000000000000006387 140.0
HKD2_k127_9199071_4 COG0367 Asparagine synthase (glutamine-hydrolyzing) - - - 0.00000000000000000000000000005912 128.0
HKD2_k127_9199071_5 - - - - 0.00000001928 64.0
HKD2_k127_9199071_6 Acetyltransferase (GNAT) domain - - - 0.0000006997 61.0
HKD2_k127_9338903_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1433.0
HKD2_k127_9338903_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 1.402e-264 829.0
HKD2_k127_9338903_2 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 3.601e-228 717.0
HKD2_k127_9338903_3 Reduces the stability of FtsZ polymers in the presence of ATP K06916 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 348.0
HKD2_k127_9338903_4 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 328.0
HKD2_k127_9338903_5 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 317.0
HKD2_k127_9338903_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008635 286.0
HKD2_k127_9338903_7 MarR family transcriptional regulator - - - 0.0000000000000000000000000000000000005603 151.0
HKD2_k127_9359994_0 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006475 263.0
HKD2_k127_9359994_1 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000005278 169.0
HKD2_k127_9359994_2 Lipocalin-like domain - - - 0.0000000000000000000000000000000001745 140.0
HKD2_k127_9359994_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000003443 143.0
HKD2_k127_9359994_4 Sigma-70, region 4 K03088 - - 0.000000002609 59.0
HKD2_k127_9376639_0 Sulfatase K01130 - 3.1.6.1 0.0 1452.0
HKD2_k127_9376639_1 Radical SAM superfamily K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 489.0
HKD2_k127_9376639_2 Sulfatase K01130 - 3.1.6.1 0.00000000000000000000000000005513 118.0