Overview

ID MAG03375
Name SHD2_bin.18
Sample SMP0083
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Micropepsales
Family Micropepsaceae
Genus Rhizomicrobium
Species
Assembly information
Completeness (%) 97.95
Contamination (%) 0.03
GC content (%) 61.0
N50 (bp) 72,071
Genome size (bp) 3,411,056

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3253

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_1073394_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 6.941e-202 637.0
SHD2_k127_1073394_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 324.0
SHD2_k127_1073394_10 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000007464 85.0
SHD2_k127_1073394_11 membrane - - - 0.0000000000002265 78.0
SHD2_k127_1073394_12 - - - - 0.000000001621 64.0
SHD2_k127_1073394_13 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.000000004164 65.0
SHD2_k127_1073394_2 DnaJ C terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 295.0
SHD2_k127_1073394_3 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 292.0
SHD2_k127_1073394_4 cAMP biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000005716 205.0
SHD2_k127_1073394_5 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000002719 159.0
SHD2_k127_1073394_6 Sulfotransferase domain K01014 - 2.8.2.1 0.000000000000000000000000000000000004593 141.0
SHD2_k127_1073394_7 - - - - 0.0000000000000000000000000000000006371 140.0
SHD2_k127_1073394_8 negative regulation of transcription, DNA-templated K10947 - - 0.000000000000000000000000000000003319 132.0
SHD2_k127_1073394_9 Domain of unknown function (DUF202) K00389 - - 0.0000000000000000000000000000001093 128.0
SHD2_k127_1105845_0 iron-nicotianamine transmembrane transporter activity - GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 1.039e-240 760.0
SHD2_k127_1105845_1 Curli production assembly/transport component CsgG K06214,K13586 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009688 317.0
SHD2_k127_1105845_2 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009068 283.0
SHD2_k127_1105845_3 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000003133 219.0
SHD2_k127_1105845_4 - K13585 - - 0.000002657 52.0
SHD2_k127_1131556_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1535.0
SHD2_k127_1131556_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18989 - - 0.0 1062.0
SHD2_k127_1131556_10 ABC transporter transmembrane region K06147 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576 - 3.674e-227 721.0
SHD2_k127_1131556_100 Belongs to the DnaA family - - - 0.00000000000000000000000000000000000000000004957 168.0
SHD2_k127_1131556_101 CDP-archaeol synthase K19664 - 2.7.7.67 0.0000000000000000000000000000000000000001952 160.0
SHD2_k127_1131556_102 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000001026 156.0
SHD2_k127_1131556_103 Protein of unknown function (DUF992) - - - 0.000000000000000000000000000000000000004139 153.0
SHD2_k127_1131556_104 rRNA binding K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000007801 144.0
SHD2_k127_1131556_105 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000001384 144.0
SHD2_k127_1131556_106 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000000000000001876 134.0
SHD2_k127_1131556_107 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000002704 134.0
SHD2_k127_1131556_108 Protein required for attachment to host cells - - - 0.0000000000000000000000000000000008978 136.0
SHD2_k127_1131556_109 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.0000000000000000000000000000003086 136.0
SHD2_k127_1131556_11 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 9.267e-213 669.0
SHD2_k127_1131556_110 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000485 127.0
SHD2_k127_1131556_111 Uncharacterized conserved protein (DUF2267) - - - 0.00000000000000000000000000007809 128.0
SHD2_k127_1131556_112 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000005849 124.0
SHD2_k127_1131556_113 PFAM Transglycosylase-associated protein - - - 0.000000000000000000000000007014 115.0
SHD2_k127_1131556_114 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000003942 109.0
SHD2_k127_1131556_115 Colicin V production protein K03558 - - 0.000000000000000000000001562 111.0
SHD2_k127_1131556_116 Preprotein translocase subunit K03210 - - 0.00000000000000000000001584 107.0
SHD2_k127_1131556_117 DNA-binding transcription factor activity - - - 0.00000000000000000001357 96.0
SHD2_k127_1131556_118 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000004985 94.0
SHD2_k127_1131556_12 DNA polymerase X family K02347 - - 1.338e-208 664.0
SHD2_k127_1131556_120 ChaB K06197 - - 0.000000000000000004345 85.0
SHD2_k127_1131556_121 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 0.0000000000000002662 86.0
SHD2_k127_1131556_122 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0003674,GO:0005215 - 0.00000000000001078 78.0
SHD2_k127_1131556_123 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000001056 76.0
SHD2_k127_1131556_124 DALR_2 K01883 - 6.1.1.16 0.000000000004866 66.0
SHD2_k127_1131556_125 - - - - 0.00000000001505 67.0
SHD2_k127_1131556_126 PAS domain - - - 0.00000000131 65.0
SHD2_k127_1131556_127 AMP-binding enzyme C-terminal domain K02182 - 6.2.1.48 0.000000007106 60.0
SHD2_k127_1131556_128 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000004479 58.0
SHD2_k127_1131556_129 acetyl-CoA C-acyltransferase activity K07513,K10527 - 1.1.1.211,1.1.1.35,2.3.1.16,4.2.1.17 0.000000457 55.0
SHD2_k127_1131556_13 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 3.44e-203 642.0
SHD2_k127_1131556_130 AMP-binding enzyme C-terminal domain K02182 - 6.2.1.48 0.0000008307 55.0
SHD2_k127_1131556_132 - - - - 0.00005278 55.0
SHD2_k127_1131556_133 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.00006274 54.0
SHD2_k127_1131556_134 Trypsin - - - 0.0001602 53.0
SHD2_k127_1131556_14 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 2.365e-200 631.0
SHD2_k127_1131556_15 ATPase components of ABC transporters with duplicated ATPase domains K06158 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 2.7e-199 640.0
SHD2_k127_1131556_16 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 571.0
SHD2_k127_1131556_17 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 557.0
SHD2_k127_1131556_18 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009698 545.0
SHD2_k127_1131556_19 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 535.0
SHD2_k127_1131556_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1017.0
SHD2_k127_1131556_20 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 517.0
SHD2_k127_1131556_21 Enoyl-CoA hydratase/isomerase K00626,K08299 - 2.3.1.9,4.2.1.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 512.0
SHD2_k127_1131556_22 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 505.0
SHD2_k127_1131556_23 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 506.0
SHD2_k127_1131556_24 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 497.0
SHD2_k127_1131556_25 PQQ-like domain K17713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005113 498.0
SHD2_k127_1131556_26 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008106 496.0
SHD2_k127_1131556_27 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 486.0
SHD2_k127_1131556_28 Major Facilitator Superfamily K13021 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 481.0
SHD2_k127_1131556_29 Alcohol dehydrogenase GroES-like domain K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 474.0
SHD2_k127_1131556_3 Belongs to the IlvD Edd family K22186 - 4.2.1.82 1.511e-313 968.0
SHD2_k127_1131556_30 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007928 482.0
SHD2_k127_1131556_31 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 460.0
SHD2_k127_1131556_32 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 477.0
SHD2_k127_1131556_33 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 451.0
SHD2_k127_1131556_34 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 439.0
SHD2_k127_1131556_35 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 421.0
SHD2_k127_1131556_36 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 413.0
SHD2_k127_1131556_37 Acyl-CoA dehydrogenase, middle domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 419.0
SHD2_k127_1131556_38 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 417.0
SHD2_k127_1131556_39 Taurine catabolism dioxygenase TauD, TfdA family K03119,K22303 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 385.0
SHD2_k127_1131556_4 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 4.978e-297 928.0
SHD2_k127_1131556_40 Acyl transferase domain K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 385.0
SHD2_k127_1131556_41 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 395.0
SHD2_k127_1131556_42 gluconolactonase activity K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 382.0
SHD2_k127_1131556_43 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 385.0
SHD2_k127_1131556_44 ATPase (AAA K06923 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 376.0
SHD2_k127_1131556_45 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005119 394.0
SHD2_k127_1131556_46 Gluconolaconase K14274 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 355.0
SHD2_k127_1131556_47 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 357.0
SHD2_k127_1131556_48 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008883 352.0
SHD2_k127_1131556_49 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 349.0
SHD2_k127_1131556_5 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 2.14e-261 812.0
SHD2_k127_1131556_50 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 332.0
SHD2_k127_1131556_51 Predicted permease YjgP/YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 338.0
SHD2_k127_1131556_52 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 339.0
SHD2_k127_1131556_53 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 332.0
SHD2_k127_1131556_54 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 316.0
SHD2_k127_1131556_55 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 309.0
SHD2_k127_1131556_56 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 316.0
SHD2_k127_1131556_57 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 304.0
SHD2_k127_1131556_58 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 306.0
SHD2_k127_1131556_59 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 303.0
SHD2_k127_1131556_6 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 7.545e-249 777.0
SHD2_k127_1131556_60 Barrel-sandwich domain of CusB or HlyD membrane-fusion K18990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 301.0
SHD2_k127_1131556_61 KR domain - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008058 292.0
SHD2_k127_1131556_62 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000419 282.0
SHD2_k127_1131556_63 Domain of unknown function (DUF1732) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003615 274.0
SHD2_k127_1131556_64 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003006 267.0
SHD2_k127_1131556_65 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000004124 274.0
SHD2_k127_1131556_66 transporter K07238,K11021 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006279 265.0
SHD2_k127_1131556_67 esterase K07214 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001022 268.0
SHD2_k127_1131556_68 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000001961 255.0
SHD2_k127_1131556_69 Belongs to the TPP enzyme family K01577,K01652 - 2.2.1.6,4.1.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000003401 254.0
SHD2_k127_1131556_7 DNA helicase K03654 - 3.6.4.12 3.538e-247 777.0
SHD2_k127_1131556_70 Dienelactone hydrolase family K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006058 252.0
SHD2_k127_1131556_71 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000005625 250.0
SHD2_k127_1131556_72 Chaperone SurA K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000009149 261.0
SHD2_k127_1131556_73 COG1560 Lauroyl myristoyl acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000000000000000001728 253.0
SHD2_k127_1131556_74 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003416 246.0
SHD2_k127_1131556_75 TIGRFAM RarD protein, DMT superfamily transporter K05786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005588 247.0
SHD2_k127_1131556_76 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000002758 246.0
SHD2_k127_1131556_77 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000002771 233.0
SHD2_k127_1131556_78 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000001283 243.0
SHD2_k127_1131556_79 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000001851 234.0
SHD2_k127_1131556_8 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.707e-238 745.0
SHD2_k127_1131556_80 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000001743 222.0
SHD2_k127_1131556_81 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 - 0.00000000000000000000000000000000000000000000000000000000000001695 218.0
SHD2_k127_1131556_82 Ribosomal protein L9, N-terminal domain K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000001739 220.0
SHD2_k127_1131556_83 Uncharacterized BCR, YaiI/YqxD family COG1671 K09768 - - 0.00000000000000000000000000000000000000000000000000000000006789 207.0
SHD2_k127_1131556_84 Squalene/phytoene synthase K02291,K18163 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000001741 213.0
SHD2_k127_1131556_85 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000001496 205.0
SHD2_k127_1131556_86 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000003872 207.0
SHD2_k127_1131556_87 Belongs to the TPP enzyme family K01577,K01652 - 2.2.1.6,4.1.1.8 0.00000000000000000000000000000000000000000000000002032 182.0
SHD2_k127_1131556_88 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000004353 190.0
SHD2_k127_1131556_89 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000001284 184.0
SHD2_k127_1131556_9 Flavin-binding monooxygenase-like - - - 3.823e-237 743.0
SHD2_k127_1131556_90 DNA polymerase III chi subunit, HolC K02339 - 2.7.7.7 0.00000000000000000000000000000000000000000000000705 183.0
SHD2_k127_1131556_91 nucleotidyltransferase activity - - - 0.00000000000000000000000000000000000000000000001566 181.0
SHD2_k127_1131556_92 Lysin motif - - - 0.000000000000000000000000000000000000000000000021 178.0
SHD2_k127_1131556_93 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000007747 175.0
SHD2_k127_1131556_94 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000004535 171.0
SHD2_k127_1131556_95 Cold shock protein domain K03704 - - 0.00000000000000000000000000000000000000000000834 171.0
SHD2_k127_1131556_96 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000009587 175.0
SHD2_k127_1131556_97 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000001071 169.0
SHD2_k127_1131556_98 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000000000000000000001993 165.0
SHD2_k127_1131556_99 Belongs to the small heat shock protein (HSP20) family - - - 0.00000000000000000000000000000000000000000002571 166.0
SHD2_k127_1143198_0 Biotin carboxylase C-terminal domain K01965 - 6.4.1.3 4.471e-287 895.0
SHD2_k127_1143198_1 PFAM carboxyl transferase K01966 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0070013,GO:0071704,GO:0072329,GO:1901575 2.1.3.15,6.4.1.3 1.776e-265 824.0
SHD2_k127_1143198_10 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 429.0
SHD2_k127_1143198_11 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 381.0
SHD2_k127_1143198_12 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 362.0
SHD2_k127_1143198_13 RNA pseudouridylate synthase K06179 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 354.0
SHD2_k127_1143198_14 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 317.0
SHD2_k127_1143198_15 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 318.0
SHD2_k127_1143198_16 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 297.0
SHD2_k127_1143198_17 Belongs to the universal ribosomal protein uS5 family K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 286.0
SHD2_k127_1143198_18 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000001367 257.0
SHD2_k127_1143198_19 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000234 248.0
SHD2_k127_1143198_2 MgsA AAA+ ATPase C terminal K07478 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 2.231e-213 669.0
SHD2_k127_1143198_20 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000003268 243.0
SHD2_k127_1143198_21 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000145 231.0
SHD2_k127_1143198_22 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000001645 220.0
SHD2_k127_1143198_23 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000002995 213.0
SHD2_k127_1143198_24 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000001267 210.0
SHD2_k127_1143198_25 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000009555 209.0
SHD2_k127_1143198_26 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000273 208.0
SHD2_k127_1143198_27 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000001682 195.0
SHD2_k127_1143198_28 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000001129 185.0
SHD2_k127_1143198_29 Chaperone required for the assembly of - - - 0.000000000000000000000000000000000000000000000000353 192.0
SHD2_k127_1143198_3 Acyl-CoA dehydrogenase, middle domain K00253 - 1.3.8.4 4.17e-208 651.0
SHD2_k127_1143198_30 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000006926 182.0
SHD2_k127_1143198_31 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000000001289 168.0
SHD2_k127_1143198_32 Cupin domain - - - 0.0000000000000000000000000000000000000000000003822 181.0
SHD2_k127_1143198_33 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000002273 165.0
SHD2_k127_1143198_34 endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000238 159.0
SHD2_k127_1143198_35 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000212 161.0
SHD2_k127_1143198_36 Sirohaem biosynthesis protein central K02304 - 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000144 144.0
SHD2_k127_1143198_37 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000000000000000001945 142.0
SHD2_k127_1143198_38 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000002815 132.0
SHD2_k127_1143198_39 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000431 139.0
SHD2_k127_1143198_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 4.576e-197 623.0
SHD2_k127_1143198_40 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000009575 116.0
SHD2_k127_1143198_41 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000002069 119.0
SHD2_k127_1143198_42 Endonuclease containing a URI domain K07461 - - 0.000000000000000000000001678 107.0
SHD2_k127_1143198_43 Type III flagellar switch regulator (C-ring) FliN C-term K02417 - - 0.000000000000000000000313 99.0
SHD2_k127_1143198_44 Beta-lactamase - - - 0.0000000000000000000003913 108.0
SHD2_k127_1143198_45 ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000005648 90.0
SHD2_k127_1143198_46 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000000000000000006541 92.0
SHD2_k127_1143198_47 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000005023 83.0
SHD2_k127_1143198_48 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000007223 80.0
SHD2_k127_1143198_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 572.0
SHD2_k127_1143198_6 M28 family peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 569.0
SHD2_k127_1143198_7 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 505.0
SHD2_k127_1143198_8 Trypsin K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 481.0
SHD2_k127_1143198_9 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005744 448.0
SHD2_k127_1279120_0 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007403 531.0
SHD2_k127_1279120_1 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000001178 223.0
SHD2_k127_1279120_2 beta-lactamase K06897 - 2.5.1.105 0.0000000000000000000000463 100.0
SHD2_k127_1281323_0 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000008905 215.0
SHD2_k127_1281323_1 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases. - - - 0.00000000000000000000005907 106.0
SHD2_k127_1405936_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 3.731e-293 928.0
SHD2_k127_1405936_1 PQQ enzyme repeat K17760 - 1.1.9.1 1.034e-227 728.0
SHD2_k127_1405936_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 326.0
SHD2_k127_1405936_11 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 321.0
SHD2_k127_1405936_12 aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000002154 267.0
SHD2_k127_1405936_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005283 257.0
SHD2_k127_1405936_14 Bacterial regulatory helix-turn-helix protein, lysR family K03566,K17850 - - 0.0000000000000000000000000000000000000000000000000000000008305 212.0
SHD2_k127_1405936_15 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.0000000000000000000000000000000000000000000000000007285 197.0
SHD2_k127_1405936_16 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000002458 181.0
SHD2_k127_1405936_17 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000002525 180.0
SHD2_k127_1405936_18 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000152 164.0
SHD2_k127_1405936_19 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.000000000000000000000000000000000000000002148 160.0
SHD2_k127_1405936_2 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 1.099e-202 653.0
SHD2_k127_1405936_20 subunit of a heme lyase K02200 - - 0.0000000000000000000000000000000001488 139.0
SHD2_k127_1405936_21 Protein of unknown function (DUF1318) K09978 - - 0.000000000000000000000000006572 117.0
SHD2_k127_1405936_22 PilZ domain - - - 0.000000000000000000000002242 110.0
SHD2_k127_1405936_23 YnbE-like lipoprotein - - - 0.000000000000000005968 85.0
SHD2_k127_1405936_24 Flp/Fap pilin component K02651 - - 0.000000000002485 68.0
SHD2_k127_1405936_25 sequence-specific DNA binding - - - 0.00001571 57.0
SHD2_k127_1405936_3 Sugar (and other) transporter K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 614.0
SHD2_k127_1405936_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 427.0
SHD2_k127_1405936_5 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 421.0
SHD2_k127_1405936_6 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 409.0
SHD2_k127_1405936_7 Putrescine transport system permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 371.0
SHD2_k127_1405936_8 Transcriptional regulatory protein, C terminal K02483 GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 351.0
SHD2_k127_1405936_9 Dicarboxylate transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 359.0
SHD2_k127_1427855_0 ABC transporter transmembrane region K06147,K18890 - - 5.677e-270 848.0
SHD2_k127_1427855_1 ABC transporter, transmembrane region K06147,K18889 - - 1.122e-232 737.0
SHD2_k127_1427855_2 Phosphoenolpyruvate phosphomutase K20454 - 4.1.3.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 379.0
SHD2_k127_1427855_3 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007055 294.0
SHD2_k127_1427855_4 signal peptide peptidase K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007687 301.0
SHD2_k127_1427855_5 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000008048 231.0
SHD2_k127_1624914_0 PFAM Integrase, catalytic region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 498.0
SHD2_k127_1624914_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008593 287.0
SHD2_k127_1809722_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 5.717e-270 839.0
SHD2_k127_1809722_1 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004067 599.0
SHD2_k127_1809722_10 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 318.0
SHD2_k127_1809722_11 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000001326 234.0
SHD2_k127_1809722_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000005021 219.0
SHD2_k127_1809722_13 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000000000000000000000000004659 195.0
SHD2_k127_1809722_14 Regulatory protein MarR - - - 0.00000000000000000000000000000000000000000003916 168.0
SHD2_k127_1809722_15 MarR family - - - 0.00000000000000000000000000000000000000002878 157.0
SHD2_k127_1809722_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008329 583.0
SHD2_k127_1809722_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008003 540.0
SHD2_k127_1809722_4 Cobalamin-independent synthase, Catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000727 485.0
SHD2_k127_1809722_5 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00018 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005212 356.0
SHD2_k127_1809722_6 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 340.0
SHD2_k127_1809722_7 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006875 329.0
SHD2_k127_1809722_8 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000051 340.0
SHD2_k127_1809722_9 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 316.0
SHD2_k127_1815668_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 6.077e-295 914.0
SHD2_k127_1815668_1 Binding-protein-dependent transport systems inner membrane component K02050 - - 3.46e-233 736.0
SHD2_k127_1815668_10 HflC and HflK could encode or regulate a protease K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 385.0
SHD2_k127_1815668_11 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 357.0
SHD2_k127_1815668_12 ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 354.0
SHD2_k127_1815668_13 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 330.0
SHD2_k127_1815668_14 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 311.0
SHD2_k127_1815668_15 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 309.0
SHD2_k127_1815668_16 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 295.0
SHD2_k127_1815668_17 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009137 291.0
SHD2_k127_1815668_18 ACT domain K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000003619 262.0
SHD2_k127_1815668_19 Protein of unknown function (DUF1428) - - - 0.000000000000000000000000000000000000000000000000000000000000003718 217.0
SHD2_k127_1815668_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 592.0
SHD2_k127_1815668_20 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.0000000000000000000000000000000000000000000000000000000000001855 215.0
SHD2_k127_1815668_21 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000000000000000000002488 205.0
SHD2_k127_1815668_22 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000000000001225 187.0
SHD2_k127_1815668_23 Cupin domain - - - 0.000000000000000000000000000000000000000000001321 169.0
SHD2_k127_1815668_24 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000355 175.0
SHD2_k127_1815668_25 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000001413 158.0
SHD2_k127_1815668_26 Protein of unknown function (DUF3761) - - - 0.0000000000000000000000000000000000000002889 156.0
SHD2_k127_1815668_27 Putative 2OG-Fe(II) oxygenase - - - 0.000000000000000000000000000000000000002141 154.0
SHD2_k127_1815668_28 - - - - 0.000000000000000000000000000000000001439 147.0
SHD2_k127_1815668_29 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000003598 136.0
SHD2_k127_1815668_3 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 587.0
SHD2_k127_1815668_30 response to cobalt ion - - - 0.0000000000000000001298 98.0
SHD2_k127_1815668_31 - - - - 0.00000007658 55.0
SHD2_k127_1815668_32 - - - - 0.00000009747 57.0
SHD2_k127_1815668_35 - - - - 0.0001133 50.0
SHD2_k127_1815668_4 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 585.0
SHD2_k127_1815668_5 NADH:flavin oxidoreductase / NADH oxidase family K09461 - 1.14.13.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007271 476.0
SHD2_k127_1815668_6 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 489.0
SHD2_k127_1815668_7 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 465.0
SHD2_k127_1815668_8 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 449.0
SHD2_k127_1815668_9 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 425.0
SHD2_k127_189387_0 AcrB/AcrD/AcrF family K03296,K07788,K07789,K21133 - - 0.0 1134.0
SHD2_k127_189387_1 GTP-binding protein TypA K06207 - - 1.232e-274 857.0
SHD2_k127_189387_10 Siphovirus Gp157 - - - 0.000004529 52.0
SHD2_k127_189387_11 sequence-specific DNA binding - - - 0.0001034 49.0
SHD2_k127_189387_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 402.0
SHD2_k127_189387_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 384.0
SHD2_k127_189387_4 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009349 347.0
SHD2_k127_189387_5 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 335.0
SHD2_k127_189387_6 Inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.0000000000000000000000000000000000000000000000000000000000000000000000000001011 266.0
SHD2_k127_189387_7 Protein of unknown function (DUF968) - - - 0.00000000000000000000000000000000000000000000000000000000000000000006457 247.0
SHD2_k127_189387_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.0000000000000000000000000000000000000000000000000000000008428 216.0
SHD2_k127_189387_9 Serine aminopeptidase, S33 K01048 - 3.1.1.5 0.0000000000000000009435 88.0
SHD2_k127_205705_0 Acetyltransferase (GNAT) domain K01905,K09181,K22224 - 6.2.1.13 5.264e-296 932.0
SHD2_k127_205705_1 AMP-binding enzyme C-terminal domain - - - 8.473e-226 709.0
SHD2_k127_205705_10 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 376.0
SHD2_k127_205705_11 Histidine kinase-like ATPases K14980 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 368.0
SHD2_k127_205705_12 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000745 346.0
SHD2_k127_205705_13 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 317.0
SHD2_k127_205705_14 Transcriptional regulatory protein, C terminal K14981 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 291.0
SHD2_k127_205705_15 Domain of unknown function (DUF4010) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 300.0
SHD2_k127_205705_16 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 288.0
SHD2_k127_205705_17 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000001249 267.0
SHD2_k127_205705_18 Protein of unknown function (DUF1223) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001151 260.0
SHD2_k127_205705_19 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002496 285.0
SHD2_k127_205705_2 Thymidine phosphorylase K00758 - 2.4.2.4 5.715e-194 617.0
SHD2_k127_205705_20 Flavodoxin-like fold K00355 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000183 209.0
SHD2_k127_205705_21 Protein of unknown function (DUF1109) - - - 0.00000000000000000000000000000000000000000000000000000939 196.0
SHD2_k127_205705_22 helix_turn_helix, cAMP Regulatory protein K01420,K15861 - - 0.00000000000000000000000000000000000000000000000000001369 199.0
SHD2_k127_205705_23 - - - - 0.000000000000000000000000000000000000000000000000001733 187.0
SHD2_k127_205705_24 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000002605 188.0
SHD2_k127_205705_25 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000003263 188.0
SHD2_k127_205705_26 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000001794 186.0
SHD2_k127_205705_27 BetI-type transcriptional repressor, C-terminal - - - 0.000000000000000000000000000000000000000000000004722 179.0
SHD2_k127_205705_28 Universal stress protein family - - - 0.0000000000000000000000000000000000000000003382 170.0
SHD2_k127_205705_29 Universal stress protein family - - - 0.00000000000000000000000000000000000000008874 163.0
SHD2_k127_205705_3 exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 591.0
SHD2_k127_205705_30 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000002694 145.0
SHD2_k127_205705_31 dioxygenase activity - - - 0.000000000000000000000000000000298 134.0
SHD2_k127_205705_32 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000000000000000000000000001906 128.0
SHD2_k127_205705_33 Universal stress protein - - - 0.000000000000000000000000000002103 132.0
SHD2_k127_205705_34 Caspase domain - - - 0.0000000000000000000000001188 118.0
SHD2_k127_205705_35 PFAM alpha beta hydrolase fold - - - 0.0000000000000000004611 87.0
SHD2_k127_205705_36 4-hydroxy-3-methylbut-2-enyl diphosphate reductase - - - 0.0000000000000000005022 89.0
SHD2_k127_205705_37 Response regulator receiver domain - - - 0.000000000000000007688 88.0
SHD2_k127_205705_38 PAS domain - - - 0.0000000000000002741 86.0
SHD2_k127_205705_39 - - - - 0.0000000000003653 74.0
SHD2_k127_205705_4 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004488 532.0
SHD2_k127_205705_40 Fatty acid desaturase K00496 GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016713,GO:0018685,GO:0043446,GO:0043448,GO:0044237,GO:0044248,GO:0055114,GO:0071704,GO:1901575 1.14.15.3 0.000000000001191 70.0
SHD2_k127_205705_41 Zinc-dependent metalloprotease - - - 0.0000004783 60.0
SHD2_k127_205705_42 Cytochrome C oxidase, cbb3-type, subunit III - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000008911 52.0
SHD2_k127_205705_43 - - - - 0.00001538 55.0
SHD2_k127_205705_5 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 525.0
SHD2_k127_205705_6 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 439.0
SHD2_k127_205705_7 KR domain K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 400.0
SHD2_k127_205705_8 PAS fold K14986 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 389.0
SHD2_k127_205705_9 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 376.0
SHD2_k127_2223303_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007567 595.0
SHD2_k127_2223303_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K15022 - 1.17.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 516.0
SHD2_k127_2223303_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000134 223.0
SHD2_k127_2223303_3 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000004468 207.0
SHD2_k127_2223303_4 Carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000001117 212.0
SHD2_k127_2254751_0 Aminotransferase, class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 519.0
SHD2_k127_2254751_1 Peptidase family M50 - - - 0.0000000004945 61.0
SHD2_k127_2263854_0 Major facilitator superfamily K08195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005583 509.0
SHD2_k127_2263854_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000007886 202.0
SHD2_k127_2263854_2 Glucose inhibited division protein A - - - 0.0000000000000000000000000000004274 123.0
SHD2_k127_2263854_3 PilZ domain - - - 0.000000000000000000001903 99.0
SHD2_k127_2347214_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 4.988e-270 839.0
SHD2_k127_2347214_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 597.0
SHD2_k127_2347214_10 FAD-linked oxidoreductase K00594 - 1.1.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 422.0
SHD2_k127_2347214_11 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 381.0
SHD2_k127_2347214_12 TIGRFAM cytochrome c oxidase, cbb3-type, subunit II K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 379.0
SHD2_k127_2347214_13 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 359.0
SHD2_k127_2347214_14 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 342.0
SHD2_k127_2347214_15 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 330.0
SHD2_k127_2347214_16 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004848 329.0
SHD2_k127_2347214_17 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006581 326.0
SHD2_k127_2347214_18 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001929 278.0
SHD2_k127_2347214_19 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001215 258.0
SHD2_k127_2347214_2 P-aminobenzoate N-oxygenase AurF - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 575.0
SHD2_k127_2347214_20 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000001163 229.0
SHD2_k127_2347214_21 Cold shock protein domain K03704 - - 0.000000000000000000000000000000000000000000000000000007296 195.0
SHD2_k127_2347214_22 Alpha-amylase domain K01187 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.20 0.0000000000000000000000000000000000000000000000000004861 190.0
SHD2_k127_2347214_24 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000001091 183.0
SHD2_k127_2347214_25 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.000000000000000000000000000000000000000000000001905 183.0
SHD2_k127_2347214_26 Phosphoribosyl-AMP cyclohydrolase K01496 - 3.5.4.19 0.000000000000000000000000000000000000004873 149.0
SHD2_k127_2347214_27 ETC complex I subunit conserved region K00329 - 1.6.5.3 0.000000000000000000000000000000000001563 142.0
SHD2_k127_2347214_28 XdhC and CoxI family - - - 0.000000000000000000000000000000000007645 139.0
SHD2_k127_2347214_29 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000000005152 140.0
SHD2_k127_2347214_3 Cytochrome c oxidase accessory protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008742 578.0
SHD2_k127_2347214_30 COG0822 NifU homolog involved in Fe-S cluster formation - - - 0.000000000000000000000000295 111.0
SHD2_k127_2347214_31 FixH - - - 0.000000000000000000000532 101.0
SHD2_k127_2347214_32 PFAM Cbb3-type cytochrome oxidase component K00407 - - 0.00000000000003847 73.0
SHD2_k127_2347214_33 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000002602 65.0
SHD2_k127_2347214_34 Tautomerase enzyme K01821 - 5.3.2.6 0.00000000127 63.0
SHD2_k127_2347214_35 EF-hand, calcium binding motif - - - 0.000000004168 67.0
SHD2_k127_2347214_36 cytochrome oxidase maturation protein - - - 0.00000002097 57.0
SHD2_k127_2347214_37 EF-hand domain pair - - - 0.0000001006 63.0
SHD2_k127_2347214_4 Pyridoxal-phosphate dependent enzyme K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 555.0
SHD2_k127_2347214_5 Probable molybdopterin binding domain K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000915 537.0
SHD2_k127_2347214_6 amino acid peptide transporter K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 510.0
SHD2_k127_2347214_7 C-terminus of AA_permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 502.0
SHD2_k127_2347214_8 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007906 477.0
SHD2_k127_2347214_9 PFAM Cys Met metabolism PLP-dependent enzyme K01760 GO:0000096,GO:0000098,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004121,GO:0006082,GO:0006090,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006520,GO:0006534,GO:0006725,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0046483,GO:0047804,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1990414 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005414 460.0
SHD2_k127_2356190_0 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000002363 219.0
SHD2_k127_2356190_1 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000002942 217.0
SHD2_k127_2356190_2 Transcriptional regulatory protein, C terminal K07657 - - 0.00000000000000000000000000000000000000001006 154.0
SHD2_k127_2356190_3 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000007187 157.0
SHD2_k127_2379902_0 PQQ-like domain K05889 - 1.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004974 519.0
SHD2_k127_2379902_1 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000009811 215.0
SHD2_k127_2379902_2 Phosphoesterase family K21302 - 3.1.3.64 0.000000000000000000000000000000000000000000000000000001472 199.0
SHD2_k127_2379902_3 methyltransferase - - - 0.000000000000000000000000000000000000000000000000001415 194.0
SHD2_k127_2379902_4 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000001541 108.0
SHD2_k127_2379902_5 - - - - 0.000000000000000000001211 96.0
SHD2_k127_2381387_0 TIGRFAM acetylornithine and succinylornithine aminotransferase K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 558.0
SHD2_k127_2381387_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 437.0
SHD2_k127_2381387_2 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006002 277.0
SHD2_k127_2381387_3 Bacterial-like globin K06886 - - 0.00000000000000000000000000000000000000000000000002181 181.0
SHD2_k127_2381387_4 GcrA cell cycle regulator K13583 - - 0.00000000000000000000000000000000000000000009747 165.0
SHD2_k127_2381387_5 Protein of unknown function (DUF992) - - - 0.00000000000000000000000000000000000001646 155.0
SHD2_k127_2381387_6 Belongs to the ompA family - - - 0.000000000000000000000000001207 123.0
SHD2_k127_2381387_7 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000019 105.0
SHD2_k127_2381387_8 - - - - 0.00000008617 57.0
SHD2_k127_2381387_9 Belongs to the ompA family - - - 0.0007567 47.0
SHD2_k127_2443491_0 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 1.766e-317 991.0
SHD2_k127_2443491_1 Biotin carboxylase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 602.0
SHD2_k127_2443491_10 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001843 269.0
SHD2_k127_2443491_11 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000007622 256.0
SHD2_k127_2443491_12 COG0346 Lactoylglutathione lyase and related lyases - - - 0.0000000000000000000000000000000000000000000000000000000000000003844 221.0
SHD2_k127_2443491_13 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000003463 166.0
SHD2_k127_2443491_14 protein conserved in bacteria - - - 0.000000000000000000000000000000000004191 142.0
SHD2_k127_2443491_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000007559 134.0
SHD2_k127_2443491_16 - - - - 0.000000000000000000000000006018 115.0
SHD2_k127_2443491_17 Thioesterase-like superfamily - - - 0.0000000000000000000000004194 115.0
SHD2_k127_2443491_18 Membrane - - - 0.00000000000000000005605 93.0
SHD2_k127_2443491_2 Glutathione S-transferase, C-terminal domain K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 531.0
SHD2_k127_2443491_3 Divergent 4Fe-4S mono-cluster - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006373 526.0
SHD2_k127_2443491_4 Acyl-CoA dehydrogenase, middle domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 488.0
SHD2_k127_2443491_5 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 389.0
SHD2_k127_2443491_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 374.0
SHD2_k127_2443491_7 Family of unknown function (DUF1028) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 323.0
SHD2_k127_2443491_8 MFS/sugar transport protein K03292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008908 308.0
SHD2_k127_2443491_9 Belongs to the helicase family. UvrD subfamily K10742 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001914 281.0
SHD2_k127_2445961_0 ImcF-related N-terminal domain K11891 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 564.0
SHD2_k127_2445961_1 Uncharacterized protein conserved in bacteria (DUF2094) K11890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001404 253.0
SHD2_k127_2445961_2 Protein phosphatase 2C K01090,K11915,K20074 - 3.1.3.16 0.0000000000000000000000000000000000002036 146.0
SHD2_k127_2447813_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 441.0
SHD2_k127_2447813_1 Dehydrogenase - - - 0.0000000000000000000000000000000000007163 157.0
SHD2_k127_2447813_2 oligosaccharyl transferase activity - - - 0.00000000000000000000000237 108.0
SHD2_k127_2500293_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1047.0
SHD2_k127_2500293_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 4.835e-313 982.0
SHD2_k127_2500293_10 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005504 309.0
SHD2_k127_2500293_11 Carbon-nitrogen hydrolase K01502 - 3.5.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004017 281.0
SHD2_k127_2500293_12 MFS_1 like family K05820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002306 269.0
SHD2_k127_2500293_13 Universal stress protein family - - - 0.000000000000000000000000000000000000000001462 162.0
SHD2_k127_2500293_14 Acyltransferase family - - - 0.00000000000000000000000000000000000433 150.0
SHD2_k127_2500293_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000001961 116.0
SHD2_k127_2500293_16 - - - - 0.0000000000000001995 89.0
SHD2_k127_2500293_17 Restriction endonuclease - - - 0.00000000004076 68.0
SHD2_k127_2500293_18 Hypoxia induced protein conserved region - - - 0.0000000003037 66.0
SHD2_k127_2500293_19 protein conserved in bacteria K09921 - - 0.000001261 59.0
SHD2_k127_2500293_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 3.271e-263 829.0
SHD2_k127_2500293_20 tetR family - - - 0.00002795 50.0
SHD2_k127_2500293_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.515e-225 706.0
SHD2_k127_2500293_4 peptidase M20 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 552.0
SHD2_k127_2500293_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 487.0
SHD2_k127_2500293_6 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 404.0
SHD2_k127_2500293_7 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 358.0
SHD2_k127_2500293_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 329.0
SHD2_k127_2500293_9 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 313.0
SHD2_k127_2584915_2 - - - - 0.00000002507 64.0
SHD2_k127_2586862_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1105.0
SHD2_k127_2586862_1 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 1.237e-288 894.0
SHD2_k127_2586862_10 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000001259 237.0
SHD2_k127_2586862_11 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000005227 214.0
SHD2_k127_2586862_12 Methylmuconolactone methyl-isomerase - - - 0.0000000000000000000000000000000000000000005145 160.0
SHD2_k127_2586862_13 PFAM type IV pilus assembly PilZ - - - 0.0000000000000000000001493 107.0
SHD2_k127_2586862_14 - - - - 0.00000000000000000001129 102.0
SHD2_k127_2586862_15 - - - - 0.0000000000002225 72.0
SHD2_k127_2586862_16 Resolvase, N terminal domain - - - 0.0000005545 54.0
SHD2_k127_2586862_17 Protein conserved in bacteria K09991 - - 0.000009926 53.0
SHD2_k127_2586862_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 8.121e-220 707.0
SHD2_k127_2586862_3 PFAM peptidase M19 renal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 479.0
SHD2_k127_2586862_4 Penicillin-binding protein 5, C-terminal domain K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 357.0
SHD2_k127_2586862_5 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 341.0
SHD2_k127_2586862_6 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009188 338.0
SHD2_k127_2586862_7 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003209 291.0
SHD2_k127_2586862_8 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000004097 240.0
SHD2_k127_2586862_9 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000009409 241.0
SHD2_k127_2734640_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 9.346e-233 728.0
SHD2_k127_2734640_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001271 281.0
SHD2_k127_2734640_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001258 276.0
SHD2_k127_2734640_3 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000004097 239.0
SHD2_k127_2734640_4 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000001141 223.0
SHD2_k127_2734640_5 - - - - 0.0000000000000000000000000000000000000000000000001618 180.0
SHD2_k127_2734640_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000212 131.0
SHD2_k127_2734640_7 Unextendable partial coding region - - - 0.000000000000003436 78.0
SHD2_k127_2734640_8 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.000001112 57.0
SHD2_k127_2734640_9 peptidyl-tyrosine sulfation - - - 0.0002615 48.0
SHD2_k127_2907625_0 Hydantoinase/oxoprolinase N-terminal region K01469 - 3.5.2.9 0.0 1367.0
SHD2_k127_2907625_1 B12 binding domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 7.868e-205 645.0
SHD2_k127_2907625_10 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 331.0
SHD2_k127_2907625_11 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006031 314.0
SHD2_k127_2907625_12 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 306.0
SHD2_k127_2907625_13 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008852 272.0
SHD2_k127_2907625_14 Tellurite resistance protein TerB K05801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000127 274.0
SHD2_k127_2907625_15 COG3023 Negative regulator of beta-lactamase expression K01447 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000004234 263.0
SHD2_k127_2907625_16 Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000000000000000000000000000000000000000000008692 224.0
SHD2_k127_2907625_17 Siderophore-interacting protein - - - 0.000000000000000000000000000000000000000000000000000000000000003047 228.0
SHD2_k127_2907625_18 Protein of unknown function (DUF1810) - - - 0.000000000000000000000000000000000000000000000000000000002586 202.0
SHD2_k127_2907625_19 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000001475 202.0
SHD2_k127_2907625_2 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004417 614.0
SHD2_k127_2907625_20 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000222 137.0
SHD2_k127_2907625_21 MraZ protein, putative antitoxin-like K03925 - - 0.000000000000000000000000003918 116.0
SHD2_k127_2907625_22 Ribbon-helix-helix protein, copG family - - - 0.0000000000000000000000508 104.0
SHD2_k127_2907625_23 - - - - 0.000000000000000000002146 97.0
SHD2_k127_2907625_24 secreted (periplasmic) protein - - - 0.000001405 55.0
SHD2_k127_2907625_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 534.0
SHD2_k127_2907625_4 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 537.0
SHD2_k127_2907625_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 471.0
SHD2_k127_2907625_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 465.0
SHD2_k127_2907625_7 COG0768 Cell division protein FtsI penicillin-binding protein 2 K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 415.0
SHD2_k127_2907625_8 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01928,K01929,K15792 - 6.3.2.10,6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 407.0
SHD2_k127_2907625_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 344.0
SHD2_k127_3243557_0 Serine protein kinase K07180 - - 0.0 1081.0
SHD2_k127_3243557_1 Sulfatase - - - 9.181e-255 794.0
SHD2_k127_3243557_10 Belongs to the UPF0229 family K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008552 505.0
SHD2_k127_3243557_11 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 473.0
SHD2_k127_3243557_12 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 463.0
SHD2_k127_3243557_13 Nucleoside transporter K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 441.0
SHD2_k127_3243557_14 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 419.0
SHD2_k127_3243557_15 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 408.0
SHD2_k127_3243557_16 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 402.0
SHD2_k127_3243557_17 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 370.0
SHD2_k127_3243557_18 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 361.0
SHD2_k127_3243557_19 GTP cyclohydrolase K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006686 304.0
SHD2_k127_3243557_2 4Fe-4S single cluster domain K06937 - - 9.444e-215 675.0
SHD2_k127_3243557_20 transcriptional regulator K02624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 312.0
SHD2_k127_3243557_21 transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 305.0
SHD2_k127_3243557_22 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 292.0
SHD2_k127_3243557_23 UreE urease accessory protein, C-terminal domain K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003248 283.0
SHD2_k127_3243557_24 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001123 285.0
SHD2_k127_3243557_25 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001037 274.0
SHD2_k127_3243557_26 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000399 252.0
SHD2_k127_3243557_27 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000002807 253.0
SHD2_k127_3243557_28 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003736 239.0
SHD2_k127_3243557_29 Prolipoprotein diacylglyceryl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006143 240.0
SHD2_k127_3243557_3 SpoVR family K06415 GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - 2.481e-206 653.0
SHD2_k127_3243557_30 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.000000000000000000000000000000000000000000000000000000000003231 219.0
SHD2_k127_3243557_31 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000000000000000000000000000000000000000139 213.0
SHD2_k127_3243557_32 nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000000000000000002335 203.0
SHD2_k127_3243557_33 Hydrolase - - - 0.0000000000000000000000000000000000000000000000000000008511 200.0
SHD2_k127_3243557_34 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000005663 195.0
SHD2_k127_3243557_35 PFAM OsmC family protein - - - 0.00000000000000000000000000000000000000000000000008597 181.0
SHD2_k127_3243557_36 Hydrolase K07025 - - 0.000000000000000000000000000000000000000000000001056 181.0
SHD2_k127_3243557_37 ApaG domain K06195 - - 0.00000000000000000000000000000000000000000000003309 173.0
SHD2_k127_3243557_38 AAA domain - - - 0.00000000000000000000000000000000000000003847 158.0
SHD2_k127_3243557_39 phosphohistidine phosphatase K08296 - - 0.000000000000000000000000000000000000002222 153.0
SHD2_k127_3243557_4 cytochrome p450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 596.0
SHD2_k127_3243557_40 PFAM Mo-dependent nitrogenase - - - 0.00000000000000000000000000000000001205 142.0
SHD2_k127_3243557_41 Glyoxalase-like domain K01759 - 4.4.1.5 0.000000000000000000000000000000000225 140.0
SHD2_k127_3243557_42 FR47-like protein - - - 0.0000000000000000000000000000001383 134.0
SHD2_k127_3243557_43 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - - 0.0000000000000000000000000000001719 126.0
SHD2_k127_3243557_44 Acyl-transferase - - - 0.0000000000000000000000006604 118.0
SHD2_k127_3243557_45 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000006756 109.0
SHD2_k127_3243557_46 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.0000000000000000000004576 104.0
SHD2_k127_3243557_47 Rhodanese-like domain - - - 0.000000000000000007279 83.0
SHD2_k127_3243557_48 Phosphotransferase enzyme family K06979 - - 0.00000000000000001251 93.0
SHD2_k127_3243557_49 PIN domain - - - 0.0000000000007903 74.0
SHD2_k127_3243557_5 Acyl-CoA dehydrogenase, C-terminal domain K06446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008402 587.0
SHD2_k127_3243557_50 PAS domain - - - 0.0000000003456 68.0
SHD2_k127_3243557_51 PAS domain - - - 0.000000002753 65.0
SHD2_k127_3243557_52 Plasmid stability protein K21495 - - 0.000005871 52.0
SHD2_k127_3243557_53 - - - - 0.00001345 52.0
SHD2_k127_3243557_6 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 563.0
SHD2_k127_3243557_7 Cobalamin-independent synthase, Catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 543.0
SHD2_k127_3243557_8 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009743 529.0
SHD2_k127_3243557_9 Prolyl oligopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 540.0
SHD2_k127_3270096_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0 1143.0
SHD2_k127_3270096_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 5e-324 1005.0
SHD2_k127_3270096_10 P-aminobenzoate N-oxygenase AurF - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 551.0
SHD2_k127_3270096_11 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 510.0
SHD2_k127_3270096_12 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006195 497.0
SHD2_k127_3270096_13 Phosphate transporter family K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006557 486.0
SHD2_k127_3270096_14 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 458.0
SHD2_k127_3270096_15 Histidine kinase K15011 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 421.0
SHD2_k127_3270096_16 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 415.0
SHD2_k127_3270096_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 385.0
SHD2_k127_3270096_18 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 377.0
SHD2_k127_3270096_19 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 372.0
SHD2_k127_3270096_2 MreB/Mbl protein K04043 - - 9.544e-314 970.0
SHD2_k127_3270096_20 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 353.0
SHD2_k127_3270096_21 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 349.0
SHD2_k127_3270096_22 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007759 345.0
SHD2_k127_3270096_23 CHASE2 K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009189 356.0
SHD2_k127_3270096_24 Imidazoleglycerol-phosphate dehydratase K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009406 309.0
SHD2_k127_3270096_25 HAD-hyrolase-like K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 297.0
SHD2_k127_3270096_26 Protein of unknown function (DUF2817) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 295.0
SHD2_k127_3270096_27 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005297 303.0
SHD2_k127_3270096_28 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000169 282.0
SHD2_k127_3270096_29 D-ala-D-ala dipeptidase K08641 - 3.4.13.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001765 276.0
SHD2_k127_3270096_3 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 3.397e-293 925.0
SHD2_k127_3270096_30 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005699 269.0
SHD2_k127_3270096_31 COG4567 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain K15012 GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006205 265.0
SHD2_k127_3270096_32 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000139 265.0
SHD2_k127_3270096_33 phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005459 254.0
SHD2_k127_3270096_34 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000001409 248.0
SHD2_k127_3270096_35 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001007 247.0
SHD2_k127_3270096_36 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 - - - 0.000000000000000000000000000000000000000000000000000000000000000002263 238.0
SHD2_k127_3270096_37 Pfam Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000002575 236.0
SHD2_k127_3270096_38 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000009828 222.0
SHD2_k127_3270096_39 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000001451 214.0
SHD2_k127_3270096_4 phenylalanyl-tRNA synthetase beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 4.937e-283 893.0
SHD2_k127_3270096_40 COG1956 GAF domain-containing protein K08968 - 1.8.4.14 0.000000000000000000000000000000000000000000000000000000000002312 212.0
SHD2_k127_3270096_41 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000004184 209.0
SHD2_k127_3270096_42 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000008342 192.0
SHD2_k127_3270096_43 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.00000000000000000000000000000000000000000000000000003385 194.0
SHD2_k127_3270096_44 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000003029 183.0
SHD2_k127_3270096_45 protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.0000000000000000000000000000000000000000000003149 174.0
SHD2_k127_3270096_46 Protein of unknown function (DUF448) K07742 - - 0.000000000000000000000000000000000000000000008217 176.0
SHD2_k127_3270096_47 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.0000000000000000000000000000000000000000002255 160.0
SHD2_k127_3270096_48 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000002302 163.0
SHD2_k127_3270096_49 ribosomal RNA adenine methylase transferase K00570 - 2.1.1.17,2.1.1.71 0.0000000000000000000000000000000000000000004971 166.0
SHD2_k127_3270096_5 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 6.852e-262 816.0
SHD2_k127_3270096_50 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000009792 164.0
SHD2_k127_3270096_51 OsmC-like protein K07397 - - 0.000000000000000000000000000000000000002052 151.0
SHD2_k127_3270096_52 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000003857 150.0
SHD2_k127_3270096_53 DNA repair protein MmcB-like - - - 0.00000000000000000000000000000000000008253 147.0
SHD2_k127_3270096_54 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000001185 138.0
SHD2_k127_3270096_55 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000321 140.0
SHD2_k127_3270096_56 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000008439 138.0
SHD2_k127_3270096_57 ASCH - - - 0.000000000000000000000000000007962 122.0
SHD2_k127_3270096_58 Sel1-like repeats. K07126,K13582 - - 0.00000000000000000000000000003429 137.0
SHD2_k127_3270096_59 protein conserved in bacteria K09973 - - 0.0000000000000000000000000004657 125.0
SHD2_k127_3270096_6 Participates in both transcription termination and antitermination K02600 - - 2.324e-237 744.0
SHD2_k127_3270096_60 - - - - 0.000000000000000000000007425 112.0
SHD2_k127_3270096_61 PFAM acid phosphatase (Class B) - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000001083 112.0
SHD2_k127_3270096_62 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate - - - 0.00000000000000000000003855 104.0
SHD2_k127_3270096_63 YGGT family K02221 - - 0.00000000000000000004592 94.0
SHD2_k127_3270096_64 Protein conserved in bacteria - - - 0.0000000000000000007561 89.0
SHD2_k127_3270096_65 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000007696 93.0
SHD2_k127_3270096_66 Belongs to the UPF0235 family K09131 - - 0.000000000000000006707 94.0
SHD2_k127_3270096_67 - - - - 0.00000000000000008629 85.0
SHD2_k127_3270096_7 S-adenosylmethionine synthetase, C-terminal domain K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 1.53e-211 663.0
SHD2_k127_3270096_70 - - - - 0.0000000000004797 76.0
SHD2_k127_3270096_71 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000001494 70.0
SHD2_k127_3270096_75 PFAM YCII-related - - - 0.00001148 53.0
SHD2_k127_3270096_8 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 1.479e-203 640.0
SHD2_k127_3270096_9 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K03921,K20087 - 1.14.19.11,1.14.19.2,1.14.19.26,1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 569.0
SHD2_k127_3298042_0 carbamoyl-phosphate synthase - - - 0.0 1328.0
SHD2_k127_3298042_1 Domain of unknown function (DUF3458_C) ARM repeats K01256 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 2.891e-297 936.0
SHD2_k127_3298042_10 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 605.0
SHD2_k127_3298042_100 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000009203 124.0
SHD2_k127_3298042_101 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000003087 116.0
SHD2_k127_3298042_102 - - - - 0.0000000000000000000000006002 109.0
SHD2_k127_3298042_103 Cytochrome c - - - 0.000000000000000000000001256 111.0
SHD2_k127_3298042_104 Transcriptional regulator K22042 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000174 103.0
SHD2_k127_3298042_106 Belongs to the UPF0434 family K09791 - - 0.00000000000000000001436 92.0
SHD2_k127_3298042_107 NfeD-like C-terminal, partner-binding K07340 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000003365 97.0
SHD2_k127_3298042_108 Protein of unknown function (DUF3298) - - - 0.0000000000000000001759 100.0
SHD2_k127_3298042_109 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000005251 88.0
SHD2_k127_3298042_11 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 591.0
SHD2_k127_3298042_110 Protein of unknown function (DUF1289) K06938 - - 0.0000000000000006976 79.0
SHD2_k127_3298042_111 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000008313 79.0
SHD2_k127_3298042_112 - - - - 0.000000000000001742 80.0
SHD2_k127_3298042_113 PFAM blue (type 1) copper domain protein - - - 0.00000000000003201 76.0
SHD2_k127_3298042_114 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.00000000000004072 78.0
SHD2_k127_3298042_115 Cytochrome B561 K12262 - - 0.0000000000003844 82.0
SHD2_k127_3298042_118 - - - - 0.000000001074 62.0
SHD2_k127_3298042_119 - - - - 0.00007869 51.0
SHD2_k127_3298042_12 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 576.0
SHD2_k127_3298042_120 Lysozyme inhibitor LprI - - - 0.0001392 53.0
SHD2_k127_3298042_13 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 572.0
SHD2_k127_3298042_14 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 559.0
SHD2_k127_3298042_15 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 545.0
SHD2_k127_3298042_16 PFAM acyl-CoA dehydrogenase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 524.0
SHD2_k127_3298042_17 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004268 506.0
SHD2_k127_3298042_18 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 492.0
SHD2_k127_3298042_19 major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 491.0
SHD2_k127_3298042_2 helicase K03722 - 3.6.4.12 6.447e-288 910.0
SHD2_k127_3298042_20 Glutamine synthetase, catalytic domain K01915 GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 477.0
SHD2_k127_3298042_21 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 465.0
SHD2_k127_3298042_22 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 467.0
SHD2_k127_3298042_23 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008097 450.0
SHD2_k127_3298042_24 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 443.0
SHD2_k127_3298042_25 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 427.0
SHD2_k127_3298042_26 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 427.0
SHD2_k127_3298042_27 Sigma-70 factor, region 1.2 K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009087 413.0
SHD2_k127_3298042_28 prohibitin homologues - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 400.0
SHD2_k127_3298042_29 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 397.0
SHD2_k127_3298042_3 amine dehydrogenase activity - - - 2.715e-278 883.0
SHD2_k127_3298042_30 enoyl-CoA hydratase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006332 391.0
SHD2_k127_3298042_31 PFAM Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 388.0
SHD2_k127_3298042_32 LysR family transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 384.0
SHD2_k127_3298042_33 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 384.0
SHD2_k127_3298042_34 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 372.0
SHD2_k127_3298042_35 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 370.0
SHD2_k127_3298042_36 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 362.0
SHD2_k127_3298042_37 cytochrome c peroxidase K00428 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009634 369.0
SHD2_k127_3298042_38 TonB-dependent Receptor Plug K16092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 383.0
SHD2_k127_3298042_39 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 362.0
SHD2_k127_3298042_4 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein - - - 2.622e-264 822.0
SHD2_k127_3298042_40 Aminoglycoside phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009498 356.0
SHD2_k127_3298042_41 Tetratricopeptide repeat K03671,K05838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 348.0
SHD2_k127_3298042_42 Esterase lipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 349.0
SHD2_k127_3298042_43 Enoyl-CoA hydratase isomerase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 342.0
SHD2_k127_3298042_44 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 336.0
SHD2_k127_3298042_45 Tetrapyrrole (Corrin/Porphyrin) Methylases K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 326.0
SHD2_k127_3298042_46 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 321.0
SHD2_k127_3298042_47 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005243 315.0
SHD2_k127_3298042_48 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 309.0
SHD2_k127_3298042_49 Aldo/keto reductase family K00064 - 1.1.1.122 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007741 310.0
SHD2_k127_3298042_5 Cellulase (glycosyl hydrolase family 5) - - - 6.158e-245 772.0
SHD2_k127_3298042_50 Inositol monophosphatase family K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 304.0
SHD2_k127_3298042_51 Protein of unknown function (DUF1348) K09958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 292.0
SHD2_k127_3298042_52 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 295.0
SHD2_k127_3298042_53 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 294.0
SHD2_k127_3298042_54 Peptidase S24-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 284.0
SHD2_k127_3298042_55 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003791 285.0
SHD2_k127_3298042_56 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009655 278.0
SHD2_k127_3298042_57 Enoyl-(Acyl carrier protein) reductase K18335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000016 284.0
SHD2_k127_3298042_58 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005053 274.0
SHD2_k127_3298042_59 Inward rectifier potassium channel K08715 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005531 277.0
SHD2_k127_3298042_6 Flavin-binding monooxygenase-like K14520 - 1.14.13.84 2.726e-243 767.0
SHD2_k127_3298042_60 COG1352 Methylase of chemotaxis methyl-accepting proteins K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003608 273.0
SHD2_k127_3298042_61 His Kinase A (phosphoacceptor) domain K07716 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000003135 280.0
SHD2_k127_3298042_62 Phenazine biosynthesis-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001893 267.0
SHD2_k127_3298042_63 Peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000002728 271.0
SHD2_k127_3298042_64 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008085 262.0
SHD2_k127_3298042_65 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003968 273.0
SHD2_k127_3298042_66 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002332 247.0
SHD2_k127_3298042_67 Pyridoxamine 5'-phosphate K07006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000272 250.0
SHD2_k127_3298042_68 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003263 250.0
SHD2_k127_3298042_69 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001201 252.0
SHD2_k127_3298042_7 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 3.889e-242 758.0
SHD2_k127_3298042_70 His Kinase A (phosphoacceptor) domain K07716 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000312 256.0
SHD2_k127_3298042_71 ATP-dependent protease La (LON) substrate-binding domain K01338,K07157 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000008113 233.0
SHD2_k127_3298042_72 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000007095 231.0
SHD2_k127_3298042_73 gag-polyprotein putative aspartyl protease - - - 0.0000000000000000000000000000000000000000000000000000000000000001865 232.0
SHD2_k127_3298042_74 - - - - 0.0000000000000000000000000000000000000000000000000000000000000717 217.0
SHD2_k127_3298042_75 Protein of unknown function (DUF1134) - - - 0.00000000000000000000000000000000000000000000000000000000002396 211.0
SHD2_k127_3298042_76 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000007324 207.0
SHD2_k127_3298042_77 LysE type translocator - GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000619 205.0
SHD2_k127_3298042_78 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000004821 198.0
SHD2_k127_3298042_79 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000000000007012 192.0
SHD2_k127_3298042_8 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 4.045e-233 731.0
SHD2_k127_3298042_80 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.00000000000000000000000000000000000000000000000000008714 194.0
SHD2_k127_3298042_81 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000000000000003156 186.0
SHD2_k127_3298042_82 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.000000000000000000000000000000000000000000000000001859 186.0
SHD2_k127_3298042_83 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000000000000000000000006395 177.0
SHD2_k127_3298042_84 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000002938 175.0
SHD2_k127_3298042_85 signal transduction histidine kinase K13588 - - 0.00000000000000000000000000000000000000000000004429 177.0
SHD2_k127_3298042_86 Acetyltransferase (GNAT) domain K22479 - - 0.0000000000000000000000000000000000000000000002187 174.0
SHD2_k127_3298042_87 Peptidase, S41 - - - 0.00000000000000000000000000000000000000000001212 181.0
SHD2_k127_3298042_88 Histidine kinase K07716 - 2.7.13.3 0.00000000000000000000000000000000000000000009886 178.0
SHD2_k127_3298042_89 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000004093 161.0
SHD2_k127_3298042_9 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 4.861e-216 682.0
SHD2_k127_3298042_90 dioxygenase activity K00477 - 1.14.11.18 0.00000000000000000000000000000000000000001665 171.0
SHD2_k127_3298042_91 Protein of unknown function (DUF971) - - - 0.0000000000000000000000000000000000000000519 157.0
SHD2_k127_3298042_92 chorismate mutase K04092 - 5.4.99.5 0.000000000000000000000000000000000000000641 151.0
SHD2_k127_3298042_93 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000001783 157.0
SHD2_k127_3298042_94 Protein of unknown function (DUF3775) - - - 0.00000000000000000000000000000000000002711 148.0
SHD2_k127_3298042_95 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000005808 153.0
SHD2_k127_3298042_96 Protein of unknown function, DUF417 - - - 0.0000000000000000000000000000000000001991 145.0
SHD2_k127_3298042_97 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000001618 135.0
SHD2_k127_3298042_98 Sulfatase - - - 0.000000000000000000000000000008978 122.0
SHD2_k127_3298042_99 protein conserved in bacteria K01876 - 6.1.1.12 0.00000000000000000000000000001422 123.0
SHD2_k127_3308966_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 1.438e-270 835.0
SHD2_k127_3308966_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001082 246.0
SHD2_k127_3422154_0 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 494.0
SHD2_k127_3422154_1 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008174 367.0
SHD2_k127_3422154_2 Rubrerythrin - - - 0.0000000000000000000000009509 109.0
SHD2_k127_3422154_3 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.00000006252 58.0
SHD2_k127_3433586_0 Acetamidase formamidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 469.0
SHD2_k127_3433586_1 2Fe-2S -binding K03518,K07302 - 1.2.5.3,1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000159 275.0
SHD2_k127_3433586_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000005061 190.0
SHD2_k127_3433586_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000005126 52.0
SHD2_k127_3433586_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00001018 53.0
SHD2_k127_3441647_0 short-chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 383.0
SHD2_k127_3441647_1 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000006517 156.0
SHD2_k127_3441647_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000003056 86.0
SHD2_k127_346068_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 4.577e-277 872.0
SHD2_k127_346068_1 Pyridoxal-phosphate dependent enzyme K01505,K05396,K17950 - 3.5.99.7,4.4.1.15,4.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008188 298.0
SHD2_k127_346068_2 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 289.0
SHD2_k127_346068_3 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002944 251.0
SHD2_k127_346068_4 xanthine catabolic process K00106,K00157 - 1.17.1.4,1.17.3.2,1.2.3.1 0.00000000000002762 75.0
SHD2_k127_3467653_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1347.0
SHD2_k127_3467653_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1154.0
SHD2_k127_3467653_10 acetyl-coa acetyltransferase K00626 - 2.3.1.9 1.155e-200 631.0
SHD2_k127_3467653_11 cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 604.0
SHD2_k127_3467653_12 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822,K00833 - 2.6.1.18,2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000794 572.0
SHD2_k127_3467653_13 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 569.0
SHD2_k127_3467653_14 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 559.0
SHD2_k127_3467653_15 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 562.0
SHD2_k127_3467653_16 Long-chain fatty aldehyde decarbonylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 560.0
SHD2_k127_3467653_17 Long-chain fatty aldehyde decarbonylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 552.0
SHD2_k127_3467653_18 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 555.0
SHD2_k127_3467653_19 cytochrome c biogenesis protein K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 554.0
SHD2_k127_3467653_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 8.655e-271 841.0
SHD2_k127_3467653_20 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 509.0
SHD2_k127_3467653_21 Alkane 1-monooxygenase K00496 - 1.14.15.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 496.0
SHD2_k127_3467653_22 taurine catabolism dioxygenase K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 454.0
SHD2_k127_3467653_23 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 427.0
SHD2_k127_3467653_24 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005855 427.0
SHD2_k127_3467653_25 Putative serine dehydratase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000089 421.0
SHD2_k127_3467653_26 Phosphoglucose isomerase K01810 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 395.0
SHD2_k127_3467653_27 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 377.0
SHD2_k127_3467653_28 Phenylalanine-4-hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 379.0
SHD2_k127_3467653_29 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 373.0
SHD2_k127_3467653_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 1.152e-249 783.0
SHD2_k127_3467653_30 Aldo Keto reductase K05275 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 361.0
SHD2_k127_3467653_31 ATP-grasp domain K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 361.0
SHD2_k127_3467653_32 N-terminal domain of oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 356.0
SHD2_k127_3467653_33 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 349.0
SHD2_k127_3467653_34 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 353.0
SHD2_k127_3467653_35 protein involved in response to NO K07234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000987 354.0
SHD2_k127_3467653_36 Predicted integral membrane protein (DUF2189) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 323.0
SHD2_k127_3467653_37 PFAM Mg2 transporter protein CorA family protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 316.0
SHD2_k127_3467653_38 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004808 315.0
SHD2_k127_3467653_39 Putative diguanylate phosphodiesterase K13593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 314.0
SHD2_k127_3467653_4 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.709e-240 764.0
SHD2_k127_3467653_40 taurine catabolism dioxygenase K03119 - 1.14.11.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009197 300.0
SHD2_k127_3467653_41 Glutathione S-transferase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000134 284.0
SHD2_k127_3467653_42 Ribosomal RNA adenine dimethylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006289 275.0
SHD2_k127_3467653_43 sugar phosphatases of the HAD superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007501 274.0
SHD2_k127_3467653_44 PFAM conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002825 267.0
SHD2_k127_3467653_45 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000009845 257.0
SHD2_k127_3467653_46 Uncharacterised protein family (UPF0262) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001111 241.0
SHD2_k127_3467653_47 Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons K01563 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000001596 249.0
SHD2_k127_3467653_48 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.000000000000000000000000000000000000000000000000000000000000000001138 232.0
SHD2_k127_3467653_49 signal peptide protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001431 233.0
SHD2_k127_3467653_5 4-hydroxyphenylacetate 3-hydroxylase K14534 - 4.2.1.120,5.3.3.3 1.856e-229 719.0
SHD2_k127_3467653_50 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001942 234.0
SHD2_k127_3467653_51 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000000000000000000000000000000000000000000000000000000006289 222.0
SHD2_k127_3467653_52 - - - - 0.0000000000000000000000000000000000000000000000000000000000001043 228.0
SHD2_k127_3467653_53 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000000000007302 209.0
SHD2_k127_3467653_54 Domain of unknown function (DUF1993) K09983 - - 0.0000000000000000000000000000000000000000000000000000000003747 209.0
SHD2_k127_3467653_55 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000000000505 207.0
SHD2_k127_3467653_56 Acetyltransferase (GNAT) domain K03830 - - 0.0000000000000000000000000000000000000000000000000000004627 197.0
SHD2_k127_3467653_57 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000776 198.0
SHD2_k127_3467653_58 Low molecular weight phosphatase family K01104,K03741 - 1.20.4.1,3.1.3.48 0.000000000000000000000000000000000000000000000000000001885 194.0
SHD2_k127_3467653_59 Thioredoxin K03672 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000002748 191.0
SHD2_k127_3467653_6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 5.247e-224 711.0
SHD2_k127_3467653_60 - - - - 0.0000000000000000000000000000000000000000000000000007888 187.0
SHD2_k127_3467653_61 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000001711 188.0
SHD2_k127_3467653_62 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000007712 179.0
SHD2_k127_3467653_63 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000344 181.0
SHD2_k127_3467653_64 N-terminal half of MaoC dehydratase K17865 - 4.2.1.55 0.00000000000000000000000000000000000000000000002524 173.0
SHD2_k127_3467653_65 acetyltransferase - - - 0.000000000000000000000000000000000000000000004236 172.0
SHD2_k127_3467653_66 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000000000000000000000000000000006759 166.0
SHD2_k127_3467653_67 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000002066 169.0
SHD2_k127_3467653_68 ferredoxin K04755 - - 0.0000000000000000000000000000000000000000009175 159.0
SHD2_k127_3467653_69 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000006991 154.0
SHD2_k127_3467653_7 Multicopper oxidase K00368 - 1.7.2.1 3.844e-216 679.0
SHD2_k127_3467653_70 lysine 2,3-aminomutase - - - 0.000000000000000000000000000000000001034 139.0
SHD2_k127_3467653_71 Protein of unknown function (DUF2948) - - - 0.000000000000000000000000000000000059 138.0
SHD2_k127_3467653_72 Usg-like family - - - 0.00000000000000000000000000000004523 126.0
SHD2_k127_3467653_73 Thioesterase superfamily - - - 0.00000000000000000000000000000007571 131.0
SHD2_k127_3467653_74 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000000006127 127.0
SHD2_k127_3467653_75 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000002914 121.0
SHD2_k127_3467653_76 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000006683 117.0
SHD2_k127_3467653_77 Methyltransferase FkbM domain - - - 0.0000000000000000000000004069 119.0
SHD2_k127_3467653_78 - - - - 0.00000000000000000000003773 106.0
SHD2_k127_3467653_79 Protein of unknown function (DUF3035) - - - 0.0000000000000000000005522 104.0
SHD2_k127_3467653_8 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 8.845e-214 666.0
SHD2_k127_3467653_80 Belongs to the rubredoxin family - - - 0.00000000000000000001282 93.0
SHD2_k127_3467653_81 - - - - 0.000000000000000002275 95.0
SHD2_k127_3467653_82 Belongs to the ompA family - - - 0.00000000000000003327 93.0
SHD2_k127_3467653_83 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000003526 80.0
SHD2_k127_3467653_84 response to cobalt ion - GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010045,GO:0010243,GO:0030288,GO:0030313,GO:0031975,GO:0032025,GO:0033554,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:1901652,GO:1901698,GO:1901700 - 0.0000000000000155 84.0
SHD2_k127_3467653_85 metal cluster binding K06940,K18475 - - 0.00000000000003591 80.0
SHD2_k127_3467653_86 PilZ domain - - - 0.0000000005509 65.0
SHD2_k127_3467653_87 Protein of unknown function (DUF3592) - - - 0.000000007201 67.0
SHD2_k127_3467653_88 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20940 - 1.14.13.218 0.00000001018 59.0
SHD2_k127_3467653_89 Protein of unknown function (DUF3096) - - - 0.00000001305 59.0
SHD2_k127_3467653_9 Amidohydrolase K07045 - - 1.231e-207 651.0
SHD2_k127_3467653_90 - - - - 0.00000003677 55.0
SHD2_k127_3467653_91 Phospholipase/Carboxylesterase - - - 0.000001621 58.0
SHD2_k127_3467653_92 - - - - 0.00000672 56.0
SHD2_k127_3467653_93 - - - - 0.00003453 51.0
SHD2_k127_3494226_0 C-terminal, D2-small domain, of ClpB protein K03695 - - 0.0 1285.0
SHD2_k127_3494226_1 AAA domain (Cdc48 subfamily) K07712 - - 5.534e-228 716.0
SHD2_k127_3494226_10 PFAM ATP-binding region ATPase domain protein K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 429.0
SHD2_k127_3494226_11 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 349.0
SHD2_k127_3494226_12 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004054 316.0
SHD2_k127_3494226_13 beta-lactamase K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 317.0
SHD2_k127_3494226_14 Catalyzes the transamination of D-amino acids and their alpha-keto acids K00824 - 2.6.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009275 316.0
SHD2_k127_3494226_15 TIGRFAM MazG family protein K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008014 294.0
SHD2_k127_3494226_16 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003499 292.0
SHD2_k127_3494226_17 Belongs to the arylamine N-acetyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003676 252.0
SHD2_k127_3494226_18 Putative sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004176 254.0
SHD2_k127_3494226_19 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000006295 247.0
SHD2_k127_3494226_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K05939 - 2.3.1.40,6.2.1.20 5.467e-217 686.0
SHD2_k127_3494226_20 glutathione transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000002866 242.0
SHD2_k127_3494226_21 Competence-damaged protein K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000006641 222.0
SHD2_k127_3494226_22 ISXO2-like transposase domain - - - 0.00000000000000000000000000000000000000000000000000000000001022 210.0
SHD2_k127_3494226_23 oligoketide cyclase lipid transport protein K18588 - - 0.000000000000000000000000000000000009976 147.0
SHD2_k127_3494226_24 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000000008038 142.0
SHD2_k127_3494226_25 PadR family transcriptional regulator K10947 - - 0.000000000000000000000000000000003 133.0
SHD2_k127_3494226_26 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363 - 0.000000000000000000000000000000004609 129.0
SHD2_k127_3494226_27 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000003474 130.0
SHD2_k127_3494226_28 Domain of unknown function (DUF4167) - - - 0.000000000000000000001436 100.0
SHD2_k127_3494226_29 Acetyltransferase (GNAT) domain - - - 0.0000001896 59.0
SHD2_k127_3494226_3 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K13598 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 1.202e-200 649.0
SHD2_k127_3494226_30 - - - - 0.000005638 57.0
SHD2_k127_3494226_4 Sigma-54 interaction domain K13599 - - 2.164e-196 622.0
SHD2_k127_3494226_5 PHB de-polymerase C-terminus K05973 - 3.1.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 524.0
SHD2_k127_3494226_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 490.0
SHD2_k127_3494226_7 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008214 476.0
SHD2_k127_3494226_8 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 454.0
SHD2_k127_3494226_9 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 449.0
SHD2_k127_3548065_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.0 1199.0
SHD2_k127_3548065_1 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 1.991e-318 981.0
SHD2_k127_3548065_10 Pfam Glycosyl transferase family 2 - - - 5.946e-220 711.0
SHD2_k127_3548065_100 - - - - 0.00000000000000000000000000000000000008684 152.0
SHD2_k127_3548065_101 protein tyrosine phosphatase - - - 0.0000000000000000000000000000000000001198 147.0
SHD2_k127_3548065_102 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000001413 150.0
SHD2_k127_3548065_103 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000395 147.0
SHD2_k127_3548065_104 MAPEG family - - - 0.00000000000000000000000000000000006993 138.0
SHD2_k127_3548065_105 Succinate dehydrogenase Fumarate reductase K00241 - - 0.0000000000000000000000000000000005268 145.0
SHD2_k127_3548065_106 SnoaL-like domain - - - 0.0000000000000000000000000000000005759 134.0
SHD2_k127_3548065_107 Predicted membrane protein (DUF2306) - - - 0.00000000000000000000000000000004102 133.0
SHD2_k127_3548065_108 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000002076 126.0
SHD2_k127_3548065_109 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000002769 124.0
SHD2_k127_3548065_11 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 595.0
SHD2_k127_3548065_110 Cell Wall Hydrolase - - - 0.00000000000000000000000000008147 124.0
SHD2_k127_3548065_111 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000001433 113.0
SHD2_k127_3548065_112 Sporulation related domain - - - 0.00000000000000000000000001921 120.0
SHD2_k127_3548065_113 Succinate dehydrogenase, hydrophobic anchor subunit K00242 - - 0.00000000000000000000000009725 117.0
SHD2_k127_3548065_114 - - - - 0.0000000000000000000000001405 114.0
SHD2_k127_3548065_115 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) K02109 - - 0.00000000000000000000001233 107.0
SHD2_k127_3548065_116 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000001214 101.0
SHD2_k127_3548065_117 Protein of unknown function (DUF3126) - - - 0.000000000000000000003564 94.0
SHD2_k127_3548065_118 Helix-turn-helix XRE-family like proteins K07729 - - 0.000000000000000000007266 93.0
SHD2_k127_3548065_119 Acetyltransferase - - - 0.00000000000000000003083 100.0
SHD2_k127_3548065_12 Belongs to the heat shock protein 70 family K04046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 567.0
SHD2_k127_3548065_120 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000002967 76.0
SHD2_k127_3548065_121 Putative prokaryotic signal transducing protein - - - 0.000000000001996 80.0
SHD2_k127_3548065_122 ThiS family K03636 - - 0.00000000004425 67.0
SHD2_k127_3548065_123 Protein of unknown function (DUF721) - - - 0.00000000008311 69.0
SHD2_k127_3548065_124 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.0000000004084 66.0
SHD2_k127_3548065_125 Protein of unknown function (DUF3572) - - - 0.0000000005498 63.0
SHD2_k127_3548065_126 UMP catabolic process - - - 0.0000001197 55.0
SHD2_k127_3548065_127 - - - - 0.000001425 55.0
SHD2_k127_3548065_128 Psort location CytoplasmicMembrane, score - - - 0.000003514 54.0
SHD2_k127_3548065_129 - - - - 0.00000361 53.0
SHD2_k127_3548065_13 diguanylate cyclase K02488 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 563.0
SHD2_k127_3548065_130 17 kDa outer membrane surface antigen - - - 0.000007815 54.0
SHD2_k127_3548065_131 SpoIIAA-like - - - 0.00001419 54.0
SHD2_k127_3548065_14 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 554.0
SHD2_k127_3548065_15 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008105 546.0
SHD2_k127_3548065_16 CoA-transferase family III K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 541.0
SHD2_k127_3548065_17 FAD linked oxidases, C-terminal domain K00102 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006982 536.0
SHD2_k127_3548065_18 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K16872 - 2.3.1.207 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 523.0
SHD2_k127_3548065_19 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 503.0
SHD2_k127_3548065_2 Required for chromosome condensation and partitioning K03529 - - 3.85e-314 999.0
SHD2_k127_3548065_20 Quinolinate synthetase A protein K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 492.0
SHD2_k127_3548065_21 glycyl-tRNA synthetase, alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007197 486.0
SHD2_k127_3548065_22 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 484.0
SHD2_k127_3548065_23 PFAM 2-nitropropane dioxygenase NPD K00459,K02371 - 1.13.12.16,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 464.0
SHD2_k127_3548065_24 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 446.0
SHD2_k127_3548065_25 quinone oxidoreductase, YhdH YhfP family K19745 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 443.0
SHD2_k127_3548065_26 oxidoreductase activity - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 439.0
SHD2_k127_3548065_27 deoxyguanosinetriphosphate triphosphohydrolase-like protein K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 445.0
SHD2_k127_3548065_28 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 432.0
SHD2_k127_3548065_29 Heparinase II/III-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 437.0
SHD2_k127_3548065_3 GAD domain K01876 - 6.1.1.12 7.253e-284 885.0
SHD2_k127_3548065_30 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 426.0
SHD2_k127_3548065_31 Tetratricopeptide repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 429.0
SHD2_k127_3548065_32 COG1194 A G-specific DNA glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 397.0
SHD2_k127_3548065_33 belongs to the nudix hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 394.0
SHD2_k127_3548065_34 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008977 383.0
SHD2_k127_3548065_35 Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 387.0
SHD2_k127_3548065_36 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 382.0
SHD2_k127_3548065_37 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 378.0
SHD2_k127_3548065_38 Belongs to the FPP GGPP synthase family K02523 GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007344 374.0
SHD2_k127_3548065_39 Belongs to the enoyl-CoA hydratase isomerase family K08299 - 4.2.1.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 364.0
SHD2_k127_3548065_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.246e-280 867.0
SHD2_k127_3548065_40 Serine acetyltransferase, N-terminal K00640 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007937 361.0
SHD2_k127_3548065_41 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 351.0
SHD2_k127_3548065_42 FAD dependent oxidoreductase K09471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 357.0
SHD2_k127_3548065_43 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 362.0
SHD2_k127_3548065_44 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 343.0
SHD2_k127_3548065_45 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 339.0
SHD2_k127_3548065_46 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 331.0
SHD2_k127_3548065_47 PFAM PhoH family protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 329.0
SHD2_k127_3548065_48 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 317.0
SHD2_k127_3548065_49 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 317.0
SHD2_k127_3548065_5 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 3.837e-278 867.0
SHD2_k127_3548065_50 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 300.0
SHD2_k127_3548065_51 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 297.0
SHD2_k127_3548065_52 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 287.0
SHD2_k127_3548065_53 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001043 289.0
SHD2_k127_3548065_54 Phosphoglycerate mutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002305 284.0
SHD2_k127_3548065_55 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007642 280.0
SHD2_k127_3548065_56 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002056 273.0
SHD2_k127_3548065_57 Putative MetA-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000446 271.0
SHD2_k127_3548065_58 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000001412 271.0
SHD2_k127_3548065_59 May be involved in the biosynthesis of molybdopterin K03638 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 2.7.7.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000008636 266.0
SHD2_k127_3548065_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.738e-266 824.0
SHD2_k127_3548065_60 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000003454 267.0
SHD2_k127_3548065_61 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004585 266.0
SHD2_k127_3548065_62 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009979 268.0
SHD2_k127_3548065_63 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002435 264.0
SHD2_k127_3548065_64 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007825 253.0
SHD2_k127_3548065_65 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000001887 255.0
SHD2_k127_3548065_66 hydrolases of HD superfamily K06952 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008726 253.0
SHD2_k127_3548065_67 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000002461 256.0
SHD2_k127_3548065_68 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000002237 258.0
SHD2_k127_3548065_69 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003271 246.0
SHD2_k127_3548065_7 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 1.159e-251 786.0
SHD2_k127_3548065_70 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000003289 241.0
SHD2_k127_3548065_71 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000002208 226.0
SHD2_k127_3548065_72 Ribonuclease HII K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000002824 226.0
SHD2_k127_3548065_73 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000008417 228.0
SHD2_k127_3548065_74 - - - - 0.000000000000000000000000000000000000000000000000000000000000003055 237.0
SHD2_k127_3548065_75 dioxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000009716 230.0
SHD2_k127_3548065_76 Response regulator receiver K11443 - - 0.0000000000000000000000000000000000000000000000000000000000002196 220.0
SHD2_k127_3548065_77 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000026 214.0
SHD2_k127_3548065_78 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000000000000000000513 218.0
SHD2_k127_3548065_79 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000005528 209.0
SHD2_k127_3548065_8 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 2.575e-238 759.0
SHD2_k127_3548065_80 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000002488 199.0
SHD2_k127_3548065_81 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000001804 198.0
SHD2_k127_3548065_82 Prokaryotic cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000000000000526 181.0
SHD2_k127_3548065_83 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000000000000005716 181.0
SHD2_k127_3548065_84 Methyltransferase small domain K15460 - 2.1.1.223 0.000000000000000000000000000000000000000000000009581 192.0
SHD2_k127_3548065_85 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000001822 173.0
SHD2_k127_3548065_86 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000001925 174.0
SHD2_k127_3548065_87 Cupin domain - - - 0.00000000000000000000000000000000000000000000002737 177.0
SHD2_k127_3548065_88 LysE type translocator - - - 0.000000000000000000000000000000000000000000003396 173.0
SHD2_k127_3548065_89 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000009928 169.0
SHD2_k127_3548065_9 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 1.962e-227 714.0
SHD2_k127_3548065_90 - - - - 0.0000000000000000000000000000000000000000002059 171.0
SHD2_k127_3548065_91 Belongs to the P(II) protein family K04751,K04752 - - 0.0000000000000000000000000000000000000000002818 160.0
SHD2_k127_3548065_92 Transcriptional regulator - - - 0.000000000000000000000000000000000000000001185 164.0
SHD2_k127_3548065_93 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000003917 160.0
SHD2_k127_3548065_94 Domain of unknown function (DUF1993) K09983 - - 0.0000000000000000000000000000000000000009025 155.0
SHD2_k127_3548065_95 Belongs to the HesB IscA family K13628,K15724 - - 0.000000000000000000000000000000000000001315 150.0
SHD2_k127_3548065_96 COG1651 Protein-disulfide isomerase - - - 0.000000000000000000000000000000000000003708 155.0
SHD2_k127_3548065_97 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000006222 154.0
SHD2_k127_3548065_98 Peptidyl-prolyl cis-trans isomerase K03772,K03773 - 5.2.1.8 0.0000000000000000000000000000000000000102 151.0
SHD2_k127_3548065_99 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000007836 148.0
SHD2_k127_3775756_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.037e-257 798.0
SHD2_k127_3775756_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 495.0
SHD2_k127_3775756_2 acyl-CoA transferases carnitine dehydratase K18702 - 2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 485.0
SHD2_k127_3775756_3 PFAM Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005729 424.0
SHD2_k127_3775756_4 Sodium/hydrogen exchanger family K03316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 349.0
SHD2_k127_3775756_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 292.0
SHD2_k127_3775756_6 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000001308 183.0
SHD2_k127_3775756_7 Stringent starvation protein B K09985 - - 0.00000000000000000000000000000000000000000001357 168.0
SHD2_k127_3775756_8 Prokaryotic cytochrome b561 K12262 - - 0.00000000000000000000000000000000000000005954 157.0
SHD2_k127_3775756_9 Ribbon-helix-helix domain - - - 0.00000000000004233 79.0
SHD2_k127_3999640_0 Reductase C-terminal K05297 - 1.18.1.1 1.391e-219 692.0
SHD2_k127_3999640_1 Protein of unknown function (DUF2945) - - - 0.00000000000000000000000000000006077 125.0
SHD2_k127_3999640_2 protein conserved in bacteria - - - 0.000000000000000000001109 98.0
SHD2_k127_4006152_0 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005369 259.0
SHD2_k127_4006152_1 Rhomboid family - - - 0.000000000000000000000000000000000000001129 156.0
SHD2_k127_4229866_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1069.0
SHD2_k127_4229866_1 Belongs to the thiolase family K00626 - 2.3.1.9 2.29e-206 647.0
SHD2_k127_4229866_2 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 299.0
SHD2_k127_4229866_3 Sulfotransferase K01014 - 2.8.2.1 0.0000000000000000000000000614 109.0
SHD2_k127_4248927_0 thiolester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006607 351.0
SHD2_k127_4248927_1 Molybdopterin binding K17225 - - 0.0006472 48.0
SHD2_k127_4249803_0 Flavin-binding monooxygenase-like - - - 1.363e-316 977.0
SHD2_k127_4249803_1 amine dehydrogenase activity - - - 9.042e-315 992.0
SHD2_k127_4249803_10 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 486.0
SHD2_k127_4249803_11 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007531 463.0
SHD2_k127_4249803_12 Luciferase-like monooxygenase K14733 - 1.14.13.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 455.0
SHD2_k127_4249803_13 N-terminal domain of oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 439.0
SHD2_k127_4249803_14 Transport of potassium into the cell K03549 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008141 430.0
SHD2_k127_4249803_15 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005129 413.0
SHD2_k127_4249803_16 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 404.0
SHD2_k127_4249803_17 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 404.0
SHD2_k127_4249803_18 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004838 389.0
SHD2_k127_4249803_19 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 395.0
SHD2_k127_4249803_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 5.558e-277 860.0
SHD2_k127_4249803_20 glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004928 364.0
SHD2_k127_4249803_21 Alcohol dehydrogenase GroES-like domain K00004 - 1.1.1.303,1.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 351.0
SHD2_k127_4249803_22 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001023 277.0
SHD2_k127_4249803_23 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000001677 242.0
SHD2_k127_4249803_24 BetI-type transcriptional repressor, C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000001051 219.0
SHD2_k127_4249803_25 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000004644 216.0
SHD2_k127_4249803_26 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000009484 206.0
SHD2_k127_4249803_27 Bacterial transcriptional repressor C-terminal - - - 0.0000000000000000000000000000000000000000000000000001874 192.0
SHD2_k127_4249803_28 Protein of unknown function (DUF1003) - - - 0.0000000000000000000000000000000000000000000000000007375 193.0
SHD2_k127_4249803_29 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000004342 188.0
SHD2_k127_4249803_3 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01576,K01652 - 2.2.1.6,4.1.1.7 1.639e-248 775.0
SHD2_k127_4249803_30 Bacterial regulatory protein, arsR family - - - 0.0000000000000000000000000000000000000000000000005641 177.0
SHD2_k127_4249803_31 Protease prsW family - - - 0.0000000000000000000000000000000000000000000000006794 188.0
SHD2_k127_4249803_32 PFAM Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000004758 177.0
SHD2_k127_4249803_33 Secretion protein K01993 - - 0.00000000000000000000000000000000000000000000002138 181.0
SHD2_k127_4249803_34 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000008493 169.0
SHD2_k127_4249803_35 protein conserved in bacteria K09973 - - 0.0000000000000000000000000000000000000000000009306 176.0
SHD2_k127_4249803_36 CHAP domain - - - 0.000000000000000000000000000000000007613 145.0
SHD2_k127_4249803_37 Isochorismatase family - - - 0.00000000000000000000000000000000003437 141.0
SHD2_k127_4249803_38 Domain of unknown function (DUF4180) - - - 0.0000000000000000000000000000000001305 138.0
SHD2_k127_4249803_39 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000002361 135.0
SHD2_k127_4249803_4 cytochrome P450 - - - 8.093e-221 691.0
SHD2_k127_4249803_40 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000153 134.0
SHD2_k127_4249803_41 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000007097 138.0
SHD2_k127_4249803_42 nitric oxide dioxygenase activity - - - 0.00000000000000000000000000000001227 132.0
SHD2_k127_4249803_43 - - - - 0.0000000000000000000000000000002517 130.0
SHD2_k127_4249803_44 Rubredoxin - - - 0.000000000000000000000000000003082 121.0
SHD2_k127_4249803_45 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.000000000000000000002257 104.0
SHD2_k127_4249803_47 Sulfurtransferase TusA K04085 - - 0.0000000000004753 72.0
SHD2_k127_4249803_48 PAS domain - - - 0.00006615 51.0
SHD2_k127_4249803_5 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 8.078e-210 663.0
SHD2_k127_4249803_6 FAD linked oxidases, C-terminal domain - - - 1.384e-198 629.0
SHD2_k127_4249803_7 K+ potassium transporter - - - 3.764e-197 634.0
SHD2_k127_4249803_8 AMP-binding enzyme K08746,K08749 - 6.2.1.3 1.148e-195 627.0
SHD2_k127_4249803_9 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 534.0
SHD2_k127_4374087_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.531e-267 831.0
SHD2_k127_4374087_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.494e-239 768.0
SHD2_k127_4374087_10 Glycosyl transferase family group 2 K20327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 499.0
SHD2_k127_4374087_11 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162,K00627 - 1.2.4.1,2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007826 466.0
SHD2_k127_4374087_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 445.0
SHD2_k127_4374087_13 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 396.0
SHD2_k127_4374087_14 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 376.0
SHD2_k127_4374087_15 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 364.0
SHD2_k127_4374087_16 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 344.0
SHD2_k127_4374087_17 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007935 344.0
SHD2_k127_4374087_18 Iron permease FTR1 family K07243 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 325.0
SHD2_k127_4374087_19 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 311.0
SHD2_k127_4374087_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 7.897e-230 725.0
SHD2_k127_4374087_20 Peptidylprolyl isomerase K01802,K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007861 317.0
SHD2_k127_4374087_21 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 293.0
SHD2_k127_4374087_22 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 283.0
SHD2_k127_4374087_23 Thioesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009827 266.0
SHD2_k127_4374087_24 Hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006633 245.0
SHD2_k127_4374087_25 Major Facilitator K08219 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000006931 248.0
SHD2_k127_4374087_26 Dienelactone hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006395 239.0
SHD2_k127_4374087_27 FAD dependent oxidoreductase K00285,K03153 - 1.4.3.19,1.4.5.1 0.0000000000000000000000000000000000000000000000000000000000000000009973 242.0
SHD2_k127_4374087_28 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351 - - 0.000000000000000000000000000000000000000000000000000000000000000004451 239.0
SHD2_k127_4374087_29 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000003406 222.0
SHD2_k127_4374087_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 4.584e-213 668.0
SHD2_k127_4374087_30 Competence-damaged protein - - - 0.000000000000000000000000000000000000000000000000000000000002109 215.0
SHD2_k127_4374087_31 protein conserved in bacteria K09798 - - 0.00000000000000000000000000000000000000000000000000000000131 219.0
SHD2_k127_4374087_32 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.0000000000000000000000000000000000000000000000000000001824 208.0
SHD2_k127_4374087_33 SCO1/SenC K07152 - - 0.00000000000000000000000000000000000000000000000000001415 196.0
SHD2_k127_4374087_34 Lytic transglycosylase - - - 0.000000000000000000000000000000000000000000000000001023 198.0
SHD2_k127_4374087_35 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000002256 177.0
SHD2_k127_4374087_36 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000000000000008154 172.0
SHD2_k127_4374087_37 - - - - 0.000000000000000000000000000000000000000000001711 166.0
SHD2_k127_4374087_38 arsenate reductase K00537 - 1.20.4.1 0.00000000000000000000000000000000000000005329 154.0
SHD2_k127_4374087_39 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.0000000000000000000000000000000000000003682 153.0
SHD2_k127_4374087_4 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 8.595e-210 660.0
SHD2_k127_4374087_40 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000006172 152.0
SHD2_k127_4374087_41 Sel1-like repeats. K07126,K13582 - - 0.00000000000000000000000000000000002666 154.0
SHD2_k127_4374087_42 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000008771 146.0
SHD2_k127_4374087_44 MAPEG family - - - 0.000000000000000000000000000006149 124.0
SHD2_k127_4374087_45 Protein of unknown function (DUF3667) - - - 0.0000000000000000000000000005978 126.0
SHD2_k127_4374087_46 Cupredoxin-like domain - - - 0.00000000000000000000000005189 112.0
SHD2_k127_4374087_47 COG0457 FOG TPR repeat - - - 0.000000000000000000000001953 111.0
SHD2_k127_4374087_48 - K20326 - - 0.00000000000000000000001173 113.0
SHD2_k127_4374087_49 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000001633 98.0
SHD2_k127_4374087_5 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 3.723e-203 644.0
SHD2_k127_4374087_50 Transcriptional regulator - - - 0.0000000000000000001971 93.0
SHD2_k127_4374087_51 Septum formation initiator - - - 0.0000000000002225 74.0
SHD2_k127_4374087_52 CDP-alcohol phosphatidyltransferase - - - 0.000000000000832 76.0
SHD2_k127_4374087_53 PAS domain - - - 0.0000000004903 67.0
SHD2_k127_4374087_54 PAS domain - - - 0.0002382 50.0
SHD2_k127_4374087_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 2.11e-196 621.0
SHD2_k127_4374087_7 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 2.877e-195 621.0
SHD2_k127_4374087_8 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008243 517.0
SHD2_k127_4374087_9 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 496.0
SHD2_k127_4398134_0 ABC transporter C-terminal domain K15738 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - 4.53e-254 796.0
SHD2_k127_4398134_1 acetyl-coa acetyltransferase K00626 - 2.3.1.9 2.615e-206 646.0
SHD2_k127_4398134_10 KR domain K18009 - 1.1.1.304,1.1.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 327.0
SHD2_k127_4398134_11 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 301.0
SHD2_k127_4398134_12 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001668 288.0
SHD2_k127_4398134_13 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000003377 205.0
SHD2_k127_4398134_14 Nodulation protein S (NodS) - - - 0.00000000000000000000000000000000000000000000000000001814 196.0
SHD2_k127_4398134_15 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000004015 195.0
SHD2_k127_4398134_16 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000002131 189.0
SHD2_k127_4398134_17 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000006229 175.0
SHD2_k127_4398134_18 MlaD protein K02067,K06192 - - 0.000000000000000000000000000000000000000000001271 176.0
SHD2_k127_4398134_19 - - - - 0.00000000000000000000000000000000000000000001011 168.0
SHD2_k127_4398134_2 ABC transporter - - - 1.082e-195 624.0
SHD2_k127_4398134_20 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000001006 167.0
SHD2_k127_4398134_21 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00000000000000000000000000000217 129.0
SHD2_k127_4398134_22 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000008766 85.0
SHD2_k127_4398134_24 Protein of unknown function (DUF1365) K09701 - - 0.0000002574 57.0
SHD2_k127_4398134_3 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 504.0
SHD2_k127_4398134_4 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 477.0
SHD2_k127_4398134_5 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006214 457.0
SHD2_k127_4398134_6 Phosphoinositide phospholipase C, Ca2+-dependent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009166 402.0
SHD2_k127_4398134_7 ATPases associated with a variety of cellular activities K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 347.0
SHD2_k127_4398134_8 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 344.0
SHD2_k127_4398134_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 329.0
SHD2_k127_4583343_0 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 1.086e-245 768.0
SHD2_k127_4583343_1 Ring hydroxylating alpha subunit (catalytic domain) - - - 3.623e-213 670.0
SHD2_k127_4583343_10 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 325.0
SHD2_k127_4583343_11 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008656 287.0
SHD2_k127_4583343_12 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002726 261.0
SHD2_k127_4583343_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000812 238.0
SHD2_k127_4583343_14 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000004275 235.0
SHD2_k127_4583343_15 - - - - 0.000000000000000000000000000000000000002923 153.0
SHD2_k127_4583343_16 DUF35 OB-fold domain, acyl-CoA-associated K07549 - - 0.000000000000000000000000000000000000006211 150.0
SHD2_k127_4583343_18 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000000000000000001062 106.0
SHD2_k127_4583343_2 acetyl-coa acetyltransferase - - - 2.433e-209 654.0
SHD2_k127_4583343_3 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 528.0
SHD2_k127_4583343_4 Transketolase, pyrimidine binding domain K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 522.0
SHD2_k127_4583343_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K00166,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 497.0
SHD2_k127_4583343_6 Short-chain dehydrogenase reductase (SDR) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 396.0
SHD2_k127_4583343_7 Ring hydroxylating alpha subunit (catalytic domain) K00499,K22443 - 1.14.13.239,1.14.15.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 383.0
SHD2_k127_4583343_8 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 361.0
SHD2_k127_4583343_9 Trehalose utilisation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 346.0
SHD2_k127_4602745_0 Dehydrogenase K15371 - 1.4.1.2 0.0 1410.0
SHD2_k127_4602745_1 Alpha-2-Macroglobulin K06894 - - 0.0 1296.0
SHD2_k127_4602745_10 GMC oxidoreductase K00108 - 1.1.99.1 1.87e-242 759.0
SHD2_k127_4602745_100 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000008059 202.0
SHD2_k127_4602745_101 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000247 197.0
SHD2_k127_4602745_102 Cupin superfamily (DUF985) K09705 - - 0.00000000000000000000000000000000000000000000000000003516 190.0
SHD2_k127_4602745_103 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000000000006559 197.0
SHD2_k127_4602745_104 - - - - 0.00000000000000000000000000000000000000000000000005346 184.0
SHD2_k127_4602745_105 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000001101 186.0
SHD2_k127_4602745_106 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000003807 184.0
SHD2_k127_4602745_107 probably involved in intracellular septation K06190 - - 0.000000000000000000000000000000000000000000000001506 181.0
SHD2_k127_4602745_108 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000002235 180.0
SHD2_k127_4602745_109 Periplasmic protein thiol disulfide oxidoreductase K02199 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000000008858 171.0
SHD2_k127_4602745_11 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 3e-231 723.0
SHD2_k127_4602745_110 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000494 166.0
SHD2_k127_4602745_111 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000002507 173.0
SHD2_k127_4602745_112 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000000000000004036 162.0
SHD2_k127_4602745_113 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000008469 163.0
SHD2_k127_4602745_114 phosphinothricin N-acetyltransferase activity K03825 - - 0.0000000000000000000000000000000000000000001179 165.0
SHD2_k127_4602745_115 Transcriptional regulator K13643 - - 0.0000000000000000000000000000000000000000007169 162.0
SHD2_k127_4602745_116 Ribosomal protein S16 K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000002988 158.0
SHD2_k127_4602745_117 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.000000000000000000000000000000000000000003917 160.0
SHD2_k127_4602745_118 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000116 160.0
SHD2_k127_4602745_119 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000001218 159.0
SHD2_k127_4602745_12 PFAM Thiamine pyrophosphate enzyme, central domain, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 1.628e-221 702.0
SHD2_k127_4602745_120 - - - - 0.00000000000000000000000000000000000000003885 154.0
SHD2_k127_4602745_121 Protein of unknown function (DUF1003) - - - 0.00000000000000000000000000000000000000004754 159.0
SHD2_k127_4602745_122 transcriptional regulator - - - 0.0000000000000000000000000000000000000002418 151.0
SHD2_k127_4602745_123 NADP transhydrogenase K00324 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 0.0000000000000000000000000000000000000004609 151.0
SHD2_k127_4602745_124 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000007819 156.0
SHD2_k127_4602745_125 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000000000000000000000004082 151.0
SHD2_k127_4602745_126 Protein of unknown function (DUF992) - - - 0.00000000000000000000000000000000000001204 151.0
SHD2_k127_4602745_127 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000001562 143.0
SHD2_k127_4602745_128 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000001685 146.0
SHD2_k127_4602745_129 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000000000001824 149.0
SHD2_k127_4602745_13 L-gulonolactone oxidase-like K00103,K00225 - 1.1.3.8,1.3.2.3 1.794e-220 692.0
SHD2_k127_4602745_130 PilZ domain - - - 0.000000000000000000000000000000000002862 146.0
SHD2_k127_4602745_131 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000003803 139.0
SHD2_k127_4602745_132 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000003854 142.0
SHD2_k127_4602745_133 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000001143 139.0
SHD2_k127_4602745_134 Protein of unknown function (DUF2853) - - - 0.00000000000000000000000000000000002051 137.0
SHD2_k127_4602745_135 DDE domain K07498 - - 0.0000000000000000000000000000000001428 136.0
SHD2_k127_4602745_136 DDE domain K07498 - - 0.000000000000000000000000000000001083 134.0
SHD2_k127_4602745_137 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000002519 136.0
SHD2_k127_4602745_138 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000000000005498 130.0
SHD2_k127_4602745_139 Belongs to the bacterial histone-like protein family K03530 - - 0.000000000000000000000000000000008731 130.0
SHD2_k127_4602745_14 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 3.008e-218 685.0
SHD2_k127_4602745_140 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000000000000308 135.0
SHD2_k127_4602745_141 Protein of unknown function (DUF1244) K09948 - - 0.00000000000000000000000000000004263 139.0
SHD2_k127_4602745_142 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000002942 126.0
SHD2_k127_4602745_143 PAP2 superfamily - - - 0.000000000000000000000000000003074 132.0
SHD2_k127_4602745_144 PFAM Transglycosylase-associated protein - - - 0.00000000000000000000000000001873 119.0
SHD2_k127_4602745_145 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - 0.00000000000000000000000000002892 130.0
SHD2_k127_4602745_146 integral membrane protein - - - 0.000000000000000000000000002159 116.0
SHD2_k127_4602745_147 Belongs to the UPF0335 family - - - 0.000000000000000000000000002168 112.0
SHD2_k127_4602745_148 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000271 117.0
SHD2_k127_4602745_149 COGs COG0726 xylanase chitin deacetylase - - - 0.000000000000000000000000002724 121.0
SHD2_k127_4602745_15 dioxygenase K11159 - - 3.146e-205 649.0
SHD2_k127_4602745_150 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000001544 119.0
SHD2_k127_4602745_151 - - - - 0.00000000000000000000000003259 111.0
SHD2_k127_4602745_152 COG0457 FOG TPR repeat - - - 0.00000000000000000000000004148 114.0
SHD2_k127_4602745_153 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000000008251 123.0
SHD2_k127_4602745_154 - - - - 0.000000000000000000000003385 104.0
SHD2_k127_4602745_155 Nickel/cobalt transporter regulator - - - 0.00000000000000000000001189 112.0
SHD2_k127_4602745_156 Domain of unknown function (DUF4442) - - - 0.00000000000000000000002059 108.0
SHD2_k127_4602745_157 YjbR - - - 0.0000000000000000000000219 106.0
SHD2_k127_4602745_158 YCII-related domain K09780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000003767 101.0
SHD2_k127_4602745_16 Belongs to the UPF0061 (SELO) family K08997 - - 1.442e-201 639.0
SHD2_k127_4602745_160 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000000000792 96.0
SHD2_k127_4602745_161 - - - - 0.00000000000000000002547 98.0
SHD2_k127_4602745_162 - - - - 0.00000000000000000002962 96.0
SHD2_k127_4602745_163 PAS domain - - - 0.00000000000000000003508 99.0
SHD2_k127_4602745_164 Class II flagellar assembly regulator - - - 0.00000000000000000004293 96.0
SHD2_k127_4602745_165 DDE domain K07498 - - 0.00000000000000000008651 94.0
SHD2_k127_4602745_166 - - - - 0.00000000000000000009448 100.0
SHD2_k127_4602745_167 COG2365 Protein tyrosine serine phosphatase - - - 0.0000000000000000005708 96.0
SHD2_k127_4602745_168 - - - - 0.000000000000000007942 88.0
SHD2_k127_4602745_169 - - - - 0.00000000000000001821 89.0
SHD2_k127_4602745_17 ABC transporter transmembrane region K06147 - - 2.158e-200 641.0
SHD2_k127_4602745_170 - - - - 0.00000000000000002625 91.0
SHD2_k127_4602745_171 Bacterial protein of unknown function (DUF937) - - - 0.0000000000000003261 79.0
SHD2_k127_4602745_172 response to cobalt ion - GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010045,GO:0010243,GO:0030288,GO:0030313,GO:0031975,GO:0032025,GO:0033554,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:1901652,GO:1901698,GO:1901700 - 0.0000000000000004189 86.0
SHD2_k127_4602745_173 - - - - 0.0000000000000009702 89.0
SHD2_k127_4602745_174 CsbD-like - - - 0.000000000000002155 78.0
SHD2_k127_4602745_175 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000000302 76.0
SHD2_k127_4602745_177 Integrase core domain - - - 0.0000000000001845 74.0
SHD2_k127_4602745_178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000009935 73.0
SHD2_k127_4602745_179 COG0790 FOG TPR repeat, SEL1 subfamily - - - 0.00000000009434 71.0
SHD2_k127_4602745_18 COG0277 FAD FMN-containing dehydrogenases K00803 - 2.5.1.26 7.269e-199 634.0
SHD2_k127_4602745_180 COG2885 outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - 0.0000000001026 73.0
SHD2_k127_4602745_181 - - - - 0.00000001788 62.0
SHD2_k127_4602745_183 DDE domain K07498 - - 0.0000003356 53.0
SHD2_k127_4602745_184 CsbD-like - - - 0.0000003609 56.0
SHD2_k127_4602745_185 4Fe-4S dicluster domain - - - 0.000004012 53.0
SHD2_k127_4602745_186 Domain of unknown function (DUF4908) - - - 0.000004092 58.0
SHD2_k127_4602745_187 - - - - 0.000005686 53.0
SHD2_k127_4602745_188 chlorophyll binding K02275,K03640 - 1.9.3.1 0.0003132 49.0
SHD2_k127_4602745_19 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 9.431e-199 631.0
SHD2_k127_4602745_2 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.0 1294.0
SHD2_k127_4602745_20 Belongs to the thiolase family K00626 - 2.3.1.9 2.633e-197 621.0
SHD2_k127_4602745_21 Pyruvate kinase, alpha/beta domain K00873 - 2.7.1.40 1.077e-195 620.0
SHD2_k127_4602745_22 AMP-binding enzyme K02182 - 6.2.1.48 1.199e-195 625.0
SHD2_k127_4602745_23 peptidase S9A prolyl oligopeptidase domain protein beta-propeller K01322 - 3.4.21.26 7.441e-194 627.0
SHD2_k127_4602745_24 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 607.0
SHD2_k127_4602745_25 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008448 598.0
SHD2_k127_4602745_26 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 583.0
SHD2_k127_4602745_27 Aminotransferase class-III K12256 - 2.6.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000646 578.0
SHD2_k127_4602745_28 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 572.0
SHD2_k127_4602745_29 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 561.0
SHD2_k127_4602745_3 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0 1260.0
SHD2_k127_4602745_30 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 570.0
SHD2_k127_4602745_31 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 548.0
SHD2_k127_4602745_32 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 513.0
SHD2_k127_4602745_33 MiaB-like tRNA modifying enzyme K18707 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008183 527.0
SHD2_k127_4602745_34 transhydrogenase subunit alpha K00324 GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 510.0
SHD2_k127_4602745_35 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000736 511.0
SHD2_k127_4602745_36 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 511.0
SHD2_k127_4602745_37 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 507.0
SHD2_k127_4602745_38 Major facilitator superfamily MFS_1 K08178 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 497.0
SHD2_k127_4602745_39 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 494.0
SHD2_k127_4602745_4 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1223.0
SHD2_k127_4602745_40 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 482.0
SHD2_k127_4602745_41 NADH flavin oxidoreductase NADH oxidase K00317,K21833 - 1.5.8.1,1.5.8.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000084 479.0
SHD2_k127_4602745_42 Fructose-bisphosphate aldolase class-I K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 477.0
SHD2_k127_4602745_43 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 470.0
SHD2_k127_4602745_44 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004996 460.0
SHD2_k127_4602745_45 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007149 445.0
SHD2_k127_4602745_46 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 444.0
SHD2_k127_4602745_47 SMART AAA ATPase K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 428.0
SHD2_k127_4602745_48 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 423.0
SHD2_k127_4602745_49 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 402.0
SHD2_k127_4602745_5 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 0.0 1024.0
SHD2_k127_4602745_50 oxidoreductases (related to aryl-alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 402.0
SHD2_k127_4602745_51 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 396.0
SHD2_k127_4602745_52 Cysteine-rich domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007534 401.0
SHD2_k127_4602745_53 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 397.0
SHD2_k127_4602745_54 Not a type III effector K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 381.0
SHD2_k127_4602745_55 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 361.0
SHD2_k127_4602745_56 KR domain K00023 - 1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 356.0
SHD2_k127_4602745_57 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005035 355.0
SHD2_k127_4602745_58 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 353.0
SHD2_k127_4602745_59 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 368.0
SHD2_k127_4602745_6 COG2217 Cation transport ATPase K17686 - 3.6.3.54 3.14e-314 979.0
SHD2_k127_4602745_60 Major facilitator Superfamily K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 349.0
SHD2_k127_4602745_61 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 344.0
SHD2_k127_4602745_62 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus K00057 GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 337.0
SHD2_k127_4602745_63 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 344.0
SHD2_k127_4602745_64 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 325.0
SHD2_k127_4602745_65 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 313.0
SHD2_k127_4602745_66 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005133 304.0
SHD2_k127_4602745_67 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009891 301.0
SHD2_k127_4602745_68 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 301.0
SHD2_k127_4602745_69 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 308.0
SHD2_k127_4602745_7 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 5.638e-266 833.0
SHD2_k127_4602745_70 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 294.0
SHD2_k127_4602745_71 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 294.0
SHD2_k127_4602745_72 Transcriptional regulator, Crp Fnr family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007071 298.0
SHD2_k127_4602745_73 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 298.0
SHD2_k127_4602745_74 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 297.0
SHD2_k127_4602745_75 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002978 286.0
SHD2_k127_4602745_76 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003301 289.0
SHD2_k127_4602745_77 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008008 274.0
SHD2_k127_4602745_78 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003442 280.0
SHD2_k127_4602745_79 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007676 270.0
SHD2_k127_4602745_8 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 3.521e-262 816.0
SHD2_k127_4602745_80 Twin-arginine translocation pathway signal protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001115 260.0
SHD2_k127_4602745_81 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001249 262.0
SHD2_k127_4602745_82 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000198 263.0
SHD2_k127_4602745_83 transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004574 260.0
SHD2_k127_4602745_84 Nudix N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006711 249.0
SHD2_k127_4602745_85 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000008864 249.0
SHD2_k127_4602745_86 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003147 249.0
SHD2_k127_4602745_87 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000946 248.0
SHD2_k127_4602745_88 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000009056 241.0
SHD2_k127_4602745_89 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000394 234.0
SHD2_k127_4602745_9 acyl-CoA dehydrogenase K09456 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 3.335e-257 801.0
SHD2_k127_4602745_90 WHG domain - - - 0.00000000000000000000000000000000000000000000000000000000000008399 218.0
SHD2_k127_4602745_91 Uncharacterized protein conserved in bacteria (DUF2332) - - - 0.0000000000000000000000000000000000000000000000000000000000004489 223.0
SHD2_k127_4602745_92 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000005151 215.0
SHD2_k127_4602745_93 Thioesterase - - - 0.0000000000000000000000000000000000000000000000000000000000005708 213.0
SHD2_k127_4602745_94 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000811 216.0
SHD2_k127_4602745_95 Polyhydroxyalkanoate synthesis repressor - - - 0.00000000000000000000000000000000000000000000000000000000001353 212.0
SHD2_k127_4602745_96 Protein of unknown function (DUF1223) - - - 0.00000000000000000000000000000000000000000000000000000000003927 215.0
SHD2_k127_4602745_97 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000001003 207.0
SHD2_k127_4602745_98 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000001129 210.0
SHD2_k127_4602745_99 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000002839 209.0
SHD2_k127_4691863_0 Involved in de novo purine biosynthesis K00602 - 2.1.2.3,3.5.4.10 4.28e-223 702.0
SHD2_k127_4691863_1 Aminotransferase class-III K00833 - 2.6.1.62 2.652e-194 614.0
SHD2_k127_4691863_10 CAAX protease self-immunity - - - 0.00000000000000008691 83.0
SHD2_k127_4691863_11 - - - - 0.000000003205 60.0
SHD2_k127_4691863_13 Protein of unknown function (DUF2905) - - - 0.00003375 50.0
SHD2_k127_4691863_2 transporter K08369 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 548.0
SHD2_k127_4691863_3 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 483.0
SHD2_k127_4691863_4 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 312.0
SHD2_k127_4691863_5 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935,K02169 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197,6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000003419 222.0
SHD2_k127_4691863_6 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.00000000000000000000000000000000000000000000000000001105 200.0
SHD2_k127_4691863_7 Protein of unknown function (DUF2089) - - - 0.00000000000000000000000000000000000000000000001165 173.0
SHD2_k127_4691863_8 - - - - 0.000000000000000000000000000000000000002577 150.0
SHD2_k127_4691863_9 CAAX protease self-immunity K07052 - - 0.0000000000000000000002075 102.0
SHD2_k127_48285_0 DEAD/H associated K03724 - - 0.0 1088.0
SHD2_k127_48285_1 Luciferase-like monooxygenase - - - 1.628e-252 783.0
SHD2_k127_48285_10 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 493.0
SHD2_k127_48285_11 Alpha-L-fucosidase K01206 - 3.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007446 470.0
SHD2_k127_48285_12 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 445.0
SHD2_k127_48285_13 Thioesterase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 438.0
SHD2_k127_48285_14 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 450.0
SHD2_k127_48285_15 Alpha beta hydrolase K01253,K08253 - 2.7.10.2,3.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004941 432.0
SHD2_k127_48285_16 PFAM short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009448 423.0
SHD2_k127_48285_17 Taurine catabolism dioxygenase TauD, TfdA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007518 424.0
SHD2_k127_48285_18 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 381.0
SHD2_k127_48285_19 (Fe-S) oxidoreductase K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 335.0
SHD2_k127_48285_2 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 1.045e-251 788.0
SHD2_k127_48285_20 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 305.0
SHD2_k127_48285_21 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001049 278.0
SHD2_k127_48285_22 infection protein K07052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001842 267.0
SHD2_k127_48285_23 Calcineurin-like phosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004186 254.0
SHD2_k127_48285_24 Sel1-like repeats. K07126,K13582 - - 0.000000000000000000000000000000000000000000000000000000000000000000001601 265.0
SHD2_k127_48285_25 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000004263 220.0
SHD2_k127_48285_26 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000002224 218.0
SHD2_k127_48285_27 Putative transmembrane protein (Alph_Pro_TM) - - - 0.0000000000000000000000000000000000000000000000000000001924 210.0
SHD2_k127_48285_28 probably involved in intracellular septation - - - 0.0000000000000000000000000000000002475 138.0
SHD2_k127_48285_29 Thioesterase superfamily - - - 0.000000000000000000000000000000001901 135.0
SHD2_k127_48285_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K18688 - 6.2.1.42 4.564e-214 676.0
SHD2_k127_48285_30 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000001411 119.0
SHD2_k127_48285_31 Tetratricopeptide repeat - - - 0.000000000000000000000000002703 126.0
SHD2_k127_48285_32 LUD domain K00782 - - 0.00000000000000000000000163 117.0
SHD2_k127_48285_33 Thioesterase superfamily - - - 0.0000000000000000000008003 100.0
SHD2_k127_48285_34 probably involved in intracellular septation - - - 0.00000000000000002928 90.0
SHD2_k127_48285_35 membrane - - - 0.00000000000001376 77.0
SHD2_k127_48285_36 Cysteine-rich secretory protein family - - - 0.0000000001048 70.0
SHD2_k127_48285_37 Protein of unknown function (DUF962) - - - 0.0000004342 58.0
SHD2_k127_48285_38 phosphinothricin N-acetyltransferase activity K18816 - 2.3.1.82 0.0000532 49.0
SHD2_k127_48285_4 Acyl-CoA dehydrogenase, middle domain K00252 - 1.3.8.6 9.998e-194 616.0
SHD2_k127_48285_5 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 587.0
SHD2_k127_48285_6 Protein of unknown function (DUF418) K07148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005132 542.0
SHD2_k127_48285_7 LUD domain K18929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006306 550.0
SHD2_k127_48285_8 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 551.0
SHD2_k127_48285_9 And related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 530.0
SHD2_k127_4949904_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 616.0
SHD2_k127_4949904_1 Beta-lactamase K01286 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 570.0
SHD2_k127_4949904_10 - - - - 0.0000000000000000000000000000000000000000000000007784 175.0
SHD2_k127_4949904_11 - - - - 0.00000000000000000000000000000000000000000000009093 180.0
SHD2_k127_4949904_12 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.0000000000000000000000000000000000000000000085 175.0
SHD2_k127_4949904_13 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000508 163.0
SHD2_k127_4949904_14 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000000000000001311 152.0
SHD2_k127_4949904_15 haemagglutination activity domain - - - 0.000000000000000000000000000000000000158 154.0
SHD2_k127_4949904_17 Protein of unknown function (DUF3761) - - - 0.000003837 53.0
SHD2_k127_4949904_2 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 487.0
SHD2_k127_4949904_3 NADP-dependent K00001,K07119 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003863 418.0
SHD2_k127_4949904_4 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 331.0
SHD2_k127_4949904_5 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 316.0
SHD2_k127_4949904_6 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001496 285.0
SHD2_k127_4949904_7 PFAM pentapeptide repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000001184 229.0
SHD2_k127_4949904_8 serine-type endopeptidase activity K08372 - - 0.000000000000000000000000000000000000000000000000000000000001141 224.0
SHD2_k127_4949904_9 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.00000000000000000000000000000000000000000000000000000001575 207.0
SHD2_k127_5008677_0 AMP-binding enzyme C-terminal domain K00666,K02182,K20034 - 6.2.1.44,6.2.1.48 6.195e-250 782.0
SHD2_k127_5008677_1 Elongator protein 3, MiaB family, Radical SAM - - - 2.854e-241 768.0
SHD2_k127_5008677_10 methyltransferase - - - 0.00000000000000000000000000000000000004884 163.0
SHD2_k127_5008677_11 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000003709 159.0
SHD2_k127_5008677_12 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000000000004867 143.0
SHD2_k127_5008677_13 Protein of unknown function (DUF1499) - - - 0.0000000000000000000000000000000000161 145.0
SHD2_k127_5008677_14 - - - - 0.0000000000000000002618 93.0
SHD2_k127_5008677_15 membrane - - - 0.00000000000000007632 89.0
SHD2_k127_5008677_16 membrane - - - 0.0000000001452 67.0
SHD2_k127_5008677_17 sequence-specific DNA binding - - - 0.000000005335 63.0
SHD2_k127_5008677_18 integral membrane protein - - - 0.00000009658 61.0
SHD2_k127_5008677_19 Uncharacterized protein family, UPF0114 - - - 0.00001025 51.0
SHD2_k127_5008677_2 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007648 398.0
SHD2_k127_5008677_20 DDE domain - - - 0.0001609 47.0
SHD2_k127_5008677_21 PAS domain - - - 0.0004327 49.0
SHD2_k127_5008677_3 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 374.0
SHD2_k127_5008677_4 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 364.0
SHD2_k127_5008677_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 337.0
SHD2_k127_5008677_6 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000708 302.0
SHD2_k127_5008677_7 WYL domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001802 280.0
SHD2_k127_5008677_8 Outer mitochondrial membrane transport complex protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001933 280.0
SHD2_k127_5008677_9 InterPro IPR014922 - - - 0.000000000000000000000000000000000000000000002563 169.0
SHD2_k127_5072871_0 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 315.0
SHD2_k127_5072871_1 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000003727 164.0
SHD2_k127_5072871_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000298 108.0
SHD2_k127_5072871_3 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000003646 93.0
SHD2_k127_5111554_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 6.161e-283 874.0
SHD2_k127_5111554_1 Esterase PHB depolymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003141 254.0
SHD2_k127_5111554_2 Transposase K07483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006494 248.0
SHD2_k127_5111554_3 IS66 Orf2 like protein K07484 - - 0.000000000000000000000000000000000000000000000000000000000000003638 219.0
SHD2_k127_5111554_4 Esterase PHB depolymerase - - - 0.0000000000000000000000000006621 115.0
SHD2_k127_5111554_5 - - - - 0.00000000006933 63.0
SHD2_k127_5111554_6 - - - - 0.00000002527 58.0
SHD2_k127_5140338_0 PFAM luciferase family protein - - - 5.339e-210 658.0
SHD2_k127_5140338_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 584.0
SHD2_k127_5140338_10 tRNA (Uracil-5-)-methyltransferase K00557,K03215 - 2.1.1.190,2.1.1.35 0.00000000267 57.0
SHD2_k127_5140338_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 476.0
SHD2_k127_5140338_3 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 430.0
SHD2_k127_5140338_4 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 417.0
SHD2_k127_5140338_5 Peptidase C13 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002614 240.0
SHD2_k127_5140338_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000002134 219.0
SHD2_k127_5140338_7 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.000000000000000000000000000000000000002803 154.0
SHD2_k127_5140338_8 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.00000000000000000000000007295 114.0
SHD2_k127_527676_0 in Yersinia the HmsR protein is an inner membrane protein K11936 - - 0.0 1269.0
SHD2_k127_527676_1 Type II/IV secretion system protein K02283 - - 4.957e-236 737.0
SHD2_k127_527676_10 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 463.0
SHD2_k127_527676_11 beta-N-acetylglucosaminidase K01197 - 3.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 452.0
SHD2_k127_527676_12 PFAM transferase hexapeptide repeat containing protein K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007503 409.0
SHD2_k127_527676_13 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005712 380.0
SHD2_k127_527676_14 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006309 379.0
SHD2_k127_527676_15 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 366.0
SHD2_k127_527676_16 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 358.0
SHD2_k127_527676_17 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 359.0
SHD2_k127_527676_18 Peptidase family S58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 356.0
SHD2_k127_527676_19 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008278 343.0
SHD2_k127_527676_2 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007164 607.0
SHD2_k127_527676_20 Type II secretion system (T2SS), protein F K12511 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005121 338.0
SHD2_k127_527676_21 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005017 327.0
SHD2_k127_527676_22 Dienelactone hydrolase and related enzymes K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009266 327.0
SHD2_k127_527676_23 Type II secretion system (T2SS), protein F K12510 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 299.0
SHD2_k127_527676_24 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 297.0
SHD2_k127_527676_25 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003591 305.0
SHD2_k127_527676_26 trans-aconitate K00598 - 2.1.1.144 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007251 288.0
SHD2_k127_527676_27 Protein conserved in bacteria K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008942 294.0
SHD2_k127_527676_28 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007322 276.0
SHD2_k127_527676_29 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005709 280.0
SHD2_k127_527676_3 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 578.0
SHD2_k127_527676_30 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003578 279.0
SHD2_k127_527676_31 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000002509 271.0
SHD2_k127_527676_32 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001517 259.0
SHD2_k127_527676_33 NlpC/P60 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001433 245.0
SHD2_k127_527676_34 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000000000000000000004729 238.0
SHD2_k127_527676_35 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000001379 243.0
SHD2_k127_527676_36 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01450,K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000009125 229.0
SHD2_k127_527676_37 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000001435 226.0
SHD2_k127_527676_38 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000001489 215.0
SHD2_k127_527676_39 PFAM cytochrome c class I K08738 - - 0.0000000000000000000000000000000000000000000000000007538 192.0
SHD2_k127_527676_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 571.0
SHD2_k127_527676_40 Hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000001388 184.0
SHD2_k127_527676_41 Protein of unknown function (DUF1036) - - - 0.0000000000000000000000000000000000000000000000001638 190.0
SHD2_k127_527676_42 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000116 165.0
SHD2_k127_527676_43 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000000000000212 165.0
SHD2_k127_527676_44 Pilus biogenesis CpaD protein (pilus_cpaD) K02281 - - 0.000000000000000000000000000001188 129.0
SHD2_k127_527676_45 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000000002088 115.0
SHD2_k127_527676_46 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000003951 105.0
SHD2_k127_527676_47 COG0457 FOG TPR repeat - - - 0.0000000000000000001082 102.0
SHD2_k127_527676_48 Bacterial type II and III secretion system protein K02280 - - 0.00000000000002372 74.0
SHD2_k127_527676_49 - - - - 0.00007543 51.0
SHD2_k127_527676_5 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005784 554.0
SHD2_k127_527676_50 Protein of unknown function (DUF805) - - - 0.0001373 48.0
SHD2_k127_527676_51 Protein of unknown function (DUF805) - - - 0.0002229 48.0
SHD2_k127_527676_6 Pilus assembly protein K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004879 511.0
SHD2_k127_527676_7 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 499.0
SHD2_k127_527676_8 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000936 483.0
SHD2_k127_527676_9 Saccharopine dehydrogenase NADP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 473.0
SHD2_k127_5288766_0 Nitrite and sulphite reductase 4Fe-4S domain K00381 - 1.8.1.2 7.579e-244 766.0
SHD2_k127_5288766_1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.121e-224 707.0
SHD2_k127_5288766_10 Major Facilitator K03762 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 401.0
SHD2_k127_5288766_11 MFS_1 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 386.0
SHD2_k127_5288766_12 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 344.0
SHD2_k127_5288766_13 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 323.0
SHD2_k127_5288766_14 Histidine kinase K11357 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 320.0
SHD2_k127_5288766_15 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002216 278.0
SHD2_k127_5288766_16 Prolyl oligopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002974 284.0
SHD2_k127_5288766_17 Cytochrome c K02305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006787 262.0
SHD2_k127_5288766_18 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001004 257.0
SHD2_k127_5288766_19 Protein of unknown function (DUF1211) - - - 0.0000000000000000000000000000000000000000000000000000000000009292 216.0
SHD2_k127_5288766_2 Belongs to the heme-copper respiratory oxidase family K04561 - 1.7.2.5 9.077e-215 674.0
SHD2_k127_5288766_20 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000001171 210.0
SHD2_k127_5288766_21 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000002872 179.0
SHD2_k127_5288766_22 Bacterial protein of unknown function (DUF934) - - - 0.0000000000000000000000000000000000000003812 156.0
SHD2_k127_5288766_23 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000005363 158.0
SHD2_k127_5288766_24 Protein of unknown function (DUF2834) - - - 0.000000000000000000000000003032 122.0
SHD2_k127_5288766_25 PFAM toluene tolerance family protein K07323 - - 0.0000000000000000000000001479 114.0
SHD2_k127_5288766_26 Protein of unknown function (DUF1491) - - - 0.0000000000000000000000002831 110.0
SHD2_k127_5288766_27 - - - - 0.00000000000000000000002853 112.0
SHD2_k127_5288766_29 Lanthionine synthetase C family protein - - - 0.00000000000000000001281 100.0
SHD2_k127_5288766_3 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 513.0
SHD2_k127_5288766_30 - - - - 0.00000000000000000003281 92.0
SHD2_k127_5288766_31 PFAM Chromosomal replication initiator DnaA domain - - - 0.0000000000000000002049 92.0
SHD2_k127_5288766_32 Protein of unknown function (DUF2849) - - - 0.000000000000000008642 88.0
SHD2_k127_5288766_33 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000005615 80.0
SHD2_k127_5288766_34 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000001904 81.0
SHD2_k127_5288766_35 Phage derived protein Gp49-like (DUF891) - - - 0.00000000000006909 81.0
SHD2_k127_5288766_36 Peptidase S9 prolyl oligopeptidase active site - - - 0.0000000000005916 81.0
SHD2_k127_5288766_37 Terminase RNaseH-like domain - - - 0.000000002536 63.0
SHD2_k127_5288766_39 Acetyltransferase (GNAT) domain - - - 0.00000003856 59.0
SHD2_k127_5288766_4 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 512.0
SHD2_k127_5288766_41 Sel1-like repeats. K07126 - - 0.000002593 55.0
SHD2_k127_5288766_42 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.000005234 56.0
SHD2_k127_5288766_43 SpoVT / AbrB like domain - - - 0.00008055 46.0
SHD2_k127_5288766_44 - - - - 0.0002502 51.0
SHD2_k127_5288766_5 Carboxylesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 484.0
SHD2_k127_5288766_6 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 447.0
SHD2_k127_5288766_7 cytochrome P450 K00493 - 1.14.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 418.0
SHD2_k127_5288766_8 NMT1/THI5 like K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 407.0
SHD2_k127_5288766_9 ISXO2-like transposase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 392.0
SHD2_k127_5291528_0 Flavin containing amine oxidoreductase - - - 1.416e-297 919.0
SHD2_k127_5291528_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 6.752e-291 904.0
SHD2_k127_5291528_10 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 314.0
SHD2_k127_5291528_11 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941,K18824 - 2.5.1.15,2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 313.0
SHD2_k127_5291528_12 COG0811 Biopolymer transport proteins K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003159 264.0
SHD2_k127_5291528_13 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000002057 250.0
SHD2_k127_5291528_14 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000009938 244.0
SHD2_k127_5291528_15 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.000000000000000000000000000000000000000000000000000624 199.0
SHD2_k127_5291528_16 Isoprenylcysteine carboxyl methyltransferase - - - 0.0000000000000000000000000000000000000000000000000009356 197.0
SHD2_k127_5291528_17 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.00000000000000000000000000000000000000000000005203 174.0
SHD2_k127_5291528_18 Lactoylglutathione lyase - - - 0.00000000000000000000000000000000000000000000007933 174.0
SHD2_k127_5291528_19 OmpA family K03640 - - 0.000000000000000000000000000000000000000000002318 169.0
SHD2_k127_5291528_2 Flavin containing amine oxidoreductase - - - 1.636e-255 801.0
SHD2_k127_5291528_20 Biopolymer transport protein K03559,K03560 - - 0.00000000000000000000000000000000000000000001124 171.0
SHD2_k127_5291528_21 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000974 156.0
SHD2_k127_5291528_22 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000000000000003672 139.0
SHD2_k127_5291528_23 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000001024 141.0
SHD2_k127_5291528_26 TIGRFAM protein TolA - - - 0.00000000000000000000000000002825 130.0
SHD2_k127_5291528_28 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000002078 109.0
SHD2_k127_5291528_3 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 2.223e-205 647.0
SHD2_k127_5291528_4 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 3.157e-203 640.0
SHD2_k127_5291528_5 Involved in the TonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 587.0
SHD2_k127_5291528_6 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000969 497.0
SHD2_k127_5291528_7 2-nitropropane dioxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 458.0
SHD2_k127_5291528_8 YmdB-like protein K09769 GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 397.0
SHD2_k127_5291528_9 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 325.0
SHD2_k127_5337882_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0 1390.0
SHD2_k127_5337882_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1349.0
SHD2_k127_5337882_10 acyl-CoA dehydrogenase - - - 2.811e-204 642.0
SHD2_k127_5337882_11 Mur ligase family, catalytic domain - - - 5.976e-198 626.0
SHD2_k127_5337882_12 Belongs to the thiolase family K00626 - 2.3.1.9 1.155e-195 616.0
SHD2_k127_5337882_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 599.0
SHD2_k127_5337882_14 TonB-dependent Receptor Plug - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 601.0
SHD2_k127_5337882_15 beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005624 569.0
SHD2_k127_5337882_16 Major Facilitator Superfamily K08169 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 554.0
SHD2_k127_5337882_17 cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 534.0
SHD2_k127_5337882_18 impB/mucB/samB family K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009872 530.0
SHD2_k127_5337882_19 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 505.0
SHD2_k127_5337882_2 Peptidase family M1 domain - - - 0.0 1349.0
SHD2_k127_5337882_20 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 505.0
SHD2_k127_5337882_21 COG1960 Acyl-CoA dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 500.0
SHD2_k127_5337882_22 HI0933 family K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 480.0
SHD2_k127_5337882_23 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 459.0
SHD2_k127_5337882_24 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 484.0
SHD2_k127_5337882_25 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004299 449.0
SHD2_k127_5337882_26 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 426.0
SHD2_k127_5337882_27 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007526 388.0
SHD2_k127_5337882_28 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 391.0
SHD2_k127_5337882_29 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 394.0
SHD2_k127_5337882_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07789 - - 0.0 1313.0
SHD2_k127_5337882_30 HlyD family secretion protein K07799,K18990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 396.0
SHD2_k127_5337882_31 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 375.0
SHD2_k127_5337882_32 Protein of unknown function (DUF1295) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 362.0
SHD2_k127_5337882_33 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 357.0
SHD2_k127_5337882_34 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 354.0
SHD2_k127_5337882_35 short-chain dehydrogenase K05296 - 1.1.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 349.0
SHD2_k127_5337882_36 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 345.0
SHD2_k127_5337882_37 Dienelactone hydrolase and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008618 340.0
SHD2_k127_5337882_38 cytochrome - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 329.0
SHD2_k127_5337882_39 proteins, homologs of microcin C7 resistance protein MccF - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 325.0
SHD2_k127_5337882_4 Sulfatase - - - 5.78e-257 799.0
SHD2_k127_5337882_40 Oxidoreductase molybdopterin binding K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 308.0
SHD2_k127_5337882_41 VirC1 protein K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 302.0
SHD2_k127_5337882_42 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 300.0
SHD2_k127_5337882_43 PFAM Glycosyl hydrolase family 10 K01181 - 3.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 302.0
SHD2_k127_5337882_44 Aldo Keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 292.0
SHD2_k127_5337882_45 N-acetylglucosaminylinositol deacetylase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007797 276.0
SHD2_k127_5337882_46 Belongs to the glycosyltransferase 26 family K05946 - 2.4.1.187 0.00000000000000000000000000000000000000000000000000000000000000000000000004789 259.0
SHD2_k127_5337882_47 Chain length determinant protein K16554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003085 267.0
SHD2_k127_5337882_48 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002877 243.0
SHD2_k127_5337882_49 MlaA lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000006334 238.0
SHD2_k127_5337882_5 dioxygenase K11159 - - 1.361e-256 797.0
SHD2_k127_5337882_50 Bacterial sugar transferase K00996,K03606 - 2.7.8.6 0.0000000000000000000000000000000000000000000000000000000000000000527 230.0
SHD2_k127_5337882_51 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000001193 227.0
SHD2_k127_5337882_52 regulatory protein TetR - - - 0.00000000000000000000000000000000000000000000000000000001893 206.0
SHD2_k127_5337882_53 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.000000000000000000000000000000000000000000000000001411 191.0
SHD2_k127_5337882_54 WHG domain - - - 0.000000000000000000000000000000000000000000000001106 187.0
SHD2_k127_5337882_55 O-Antigen ligase - - - 0.000000000000000000000000000000000000000000000001768 190.0
SHD2_k127_5337882_56 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000007688 178.0
SHD2_k127_5337882_57 PFAM GumN family protein - - - 0.00000000000000000000000000000000000000000000001206 184.0
SHD2_k127_5337882_58 ATP-grasp domain - - - 0.00000000000000000000000000000000000000000000005899 184.0
SHD2_k127_5337882_59 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000007752 160.0
SHD2_k127_5337882_6 FAD dependent oxidoreductase K07137 - - 7.434e-256 800.0
SHD2_k127_5337882_60 polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000001369 160.0
SHD2_k127_5337882_61 Psort location OuterMembrane, score 9.92 K03772 - 5.2.1.8 0.00000000000000000000000000000000008873 139.0
SHD2_k127_5337882_62 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000001177 128.0
SHD2_k127_5337882_64 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000008182 104.0
SHD2_k127_5337882_65 Invasion associated locus B (IalB) protein - - - 0.00000000000000000004224 98.0
SHD2_k127_5337882_66 endonuclease containing a URI domain K07461 - - 0.000000000000000004259 89.0
SHD2_k127_5337882_67 SOS response K14160 - - 0.000000000000000005054 94.0
SHD2_k127_5337882_68 Polysaccharide deacetylase - - - 0.000000000000003959 87.0
SHD2_k127_5337882_69 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000002434 72.0
SHD2_k127_5337882_7 PFAM AMP-dependent synthetase and ligase K00666,K18688 - 6.2.1.42 5.825e-254 792.0
SHD2_k127_5337882_70 PFAM Invasion associated locus B - - - 0.000000003096 67.0
SHD2_k127_5337882_71 Sulfatase-modifying factor enzyme 1 - - - 0.00000006569 55.0
SHD2_k127_5337882_72 Sulfatase-modifying factor enzyme 1 - - - 0.0000003716 51.0
SHD2_k127_5337882_73 Sulfatase-modifying factor enzyme 1 - - - 0.000002438 49.0
SHD2_k127_5337882_8 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 5.009e-209 664.0
SHD2_k127_5337882_9 Acyl-CoA dehydrogenase, C-terminal domain - - - 1.11e-208 651.0
SHD2_k127_5343854_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 1.36e-237 751.0
SHD2_k127_5343854_1 Aminotransferase K14261 - - 3.749e-196 617.0
SHD2_k127_5343854_10 Sir2 family K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008234 351.0
SHD2_k127_5343854_11 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 334.0
SHD2_k127_5343854_12 Maltogenic Amylase, C-terminal domain K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 334.0
SHD2_k127_5343854_13 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 331.0
SHD2_k127_5343854_14 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 320.0
SHD2_k127_5343854_15 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 290.0
SHD2_k127_5343854_16 serine-type endopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000911 277.0
SHD2_k127_5343854_17 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000757 246.0
SHD2_k127_5343854_18 structural constituent of ribosome K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000684 214.0
SHD2_k127_5343854_19 CoA binding domain K06929 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000221 205.0
SHD2_k127_5343854_2 Cys/Met metabolism PLP-dependent enzyme K01738,K01740 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 597.0
SHD2_k127_5343854_20 acetyl-coa acetyltransferase - - - 0.000000000000000000000000000000000009923 136.0
SHD2_k127_5343854_21 Putative FMN-binding domain K07734 - - 0.0000000000000000000000000000000003686 140.0
SHD2_k127_5343854_22 OmpA family - - - 0.00000000000000000000000003558 123.0
SHD2_k127_5343854_23 Protein of unknown function (DUF805) - - - 0.000000000504 67.0
SHD2_k127_5343854_24 Protein of unknown function (DUF2842) - - - 0.000000001482 61.0
SHD2_k127_5343854_3 DHH family K07462 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 552.0
SHD2_k127_5343854_4 tetratricopeptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006038 501.0
SHD2_k127_5343854_5 Fructose-1,6-bisphosphatase K02446,K11532 - 3.1.3.11,3.1.3.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 442.0
SHD2_k127_5343854_6 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 437.0
SHD2_k127_5343854_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 404.0
SHD2_k127_5343854_8 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009217 383.0
SHD2_k127_5343854_9 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 379.0
SHD2_k127_5352693_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 3.429e-254 797.0
SHD2_k127_5352693_1 COG4166 ABC-type oligopeptide transport system, periplasmic component K02035,K15580 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 508.0
SHD2_k127_5352693_2 COG4166 ABC-type oligopeptide transport system, periplasmic component K02035,K15580 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 458.0
SHD2_k127_5352693_3 COG4166 ABC-type oligopeptide transport system, periplasmic component K02035,K15580 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 452.0
SHD2_k127_5352693_4 Binding-protein-dependent transport system inner membrane component K15581 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 421.0
SHD2_k127_5352693_5 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 416.0
SHD2_k127_5352693_6 extracellular solute-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001443 291.0
SHD2_k127_5352693_7 - - - - 0.0000000001896 66.0
SHD2_k127_5352693_8 - - - - 0.000003246 57.0
SHD2_k127_5387423_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1672.0
SHD2_k127_5387423_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 3.828e-298 920.0
SHD2_k127_5387423_10 Arginyl-tRNA synthetase K01887 - 6.1.1.19 5.378e-209 670.0
SHD2_k127_5387423_100 Protein of unknown function (DUF952) - - - 0.00000000000000000000000003365 120.0
SHD2_k127_5387423_101 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.0000000000000000000000001367 113.0
SHD2_k127_5387423_102 SnoaL-like polyketide cyclase - - - 0.000000000000000000000003372 108.0
SHD2_k127_5387423_103 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.000000000000000000001097 100.0
SHD2_k127_5387423_104 Uncharacterized protein conserved in bacteria (DUF2093) - - - 0.000000000000000000002805 94.0
SHD2_k127_5387423_105 TfoX N-terminal domain K07343 - - 0.00000000000000001176 87.0
SHD2_k127_5387423_106 Pentapeptide repeats (9 copies) - - - 0.000000000000000121 88.0
SHD2_k127_5387423_107 Activator of Hsp90 ATPase homolog 1-like - - - 0.000000000000003651 87.0
SHD2_k127_5387423_108 - - - - 0.00000000000007636 78.0
SHD2_k127_5387423_109 Transcription regulator MerR, DNA binding - - - 0.0000000000003489 76.0
SHD2_k127_5387423_11 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 1.418e-200 659.0
SHD2_k127_5387423_110 phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.000000000017 75.0
SHD2_k127_5387423_111 - - - - 0.00000000003363 68.0
SHD2_k127_5387423_112 - - - - 0.0000695 46.0
SHD2_k127_5387423_12 peptidase M13 K07386 - - 2.013e-198 640.0
SHD2_k127_5387423_13 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 3.998e-195 618.0
SHD2_k127_5387423_14 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 3.992e-194 642.0
SHD2_k127_5387423_15 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 606.0
SHD2_k127_5387423_16 Glutamate-cysteine ligase family 2(GCS2) K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 595.0
SHD2_k127_5387423_17 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007615 569.0
SHD2_k127_5387423_18 Zn-dependent proteases and their inactivated homologs K03592 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 551.0
SHD2_k127_5387423_19 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 550.0
SHD2_k127_5387423_2 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 3.865e-273 862.0
SHD2_k127_5387423_20 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 540.0
SHD2_k127_5387423_21 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007942 532.0
SHD2_k127_5387423_22 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 528.0
SHD2_k127_5387423_23 C-terminus of AA_permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000549 526.0
SHD2_k127_5387423_24 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 512.0
SHD2_k127_5387423_25 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 515.0
SHD2_k127_5387423_26 PFAM major facilitator superfamily MFS_1 K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 497.0
SHD2_k127_5387423_27 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004688 491.0
SHD2_k127_5387423_28 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 483.0
SHD2_k127_5387423_29 ABC-type multidrug transport system, ATPase and permease K02021,K06147,K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002593 476.0
SHD2_k127_5387423_3 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 1.21e-272 844.0
SHD2_k127_5387423_30 Threonine synthase K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009846 471.0
SHD2_k127_5387423_31 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 456.0
SHD2_k127_5387423_32 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 443.0
SHD2_k127_5387423_33 COG0625 Glutathione S-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006501 434.0
SHD2_k127_5387423_34 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 420.0
SHD2_k127_5387423_35 Glycine cleavage T-protein C-terminal barrel domain K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 419.0
SHD2_k127_5387423_36 Phosphotransferase enzyme family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 399.0
SHD2_k127_5387423_37 Phosphoesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 396.0
SHD2_k127_5387423_38 cytochrome c oxidase subunit III K02276 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 393.0
SHD2_k127_5387423_39 RsgA GTPase K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 392.0
SHD2_k127_5387423_4 Uncharacterized protein family (UPF0051) K09014 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0009842,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 5.245e-256 796.0
SHD2_k127_5387423_40 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 392.0
SHD2_k127_5387423_41 Putative diguanylate phosphodiesterase K13245 - 3.1.4.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 409.0
SHD2_k127_5387423_42 TIGRFAM FeS assembly ATPase SufC K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 367.0
SHD2_k127_5387423_43 Fatty acid desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 362.0
SHD2_k127_5387423_44 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 369.0
SHD2_k127_5387423_45 Protein of unknown function - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 384.0
SHD2_k127_5387423_46 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 347.0
SHD2_k127_5387423_47 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 343.0
SHD2_k127_5387423_48 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179,K06125 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 335.0
SHD2_k127_5387423_49 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 341.0
SHD2_k127_5387423_5 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 3.907e-248 783.0
SHD2_k127_5387423_50 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 326.0
SHD2_k127_5387423_51 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 324.0
SHD2_k127_5387423_52 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006229 336.0
SHD2_k127_5387423_53 S4 RNA-binding domain K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 322.0
SHD2_k127_5387423_54 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 317.0
SHD2_k127_5387423_55 X-Pro dipeptidyl-peptidase (S15 family) K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 294.0
SHD2_k127_5387423_56 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 287.0
SHD2_k127_5387423_57 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006746 289.0
SHD2_k127_5387423_58 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009068 283.0
SHD2_k127_5387423_59 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001543 288.0
SHD2_k127_5387423_6 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 3.368e-234 732.0
SHD2_k127_5387423_60 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002187 278.0
SHD2_k127_5387423_61 Lysine methyltransferase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000362 269.0
SHD2_k127_5387423_62 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000838 267.0
SHD2_k127_5387423_63 COG0861 Membrane protein TerC, possibly involved in tellurium resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001155 264.0
SHD2_k127_5387423_64 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000001398 265.0
SHD2_k127_5387423_65 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000000000000000000000000001513 256.0
SHD2_k127_5387423_66 COG1560 Lauroyl myristoyl acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000227 250.0
SHD2_k127_5387423_67 Nucleotidyltransferase K09962 - - 0.000000000000000000000000000000000000000000000000000000000000000000000333 244.0
SHD2_k127_5387423_68 Belongs to the EutC family K03736 - 4.3.1.7 0.0000000000000000000000000000000000000000000000000000000000000000001543 238.0
SHD2_k127_5387423_69 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000205 237.0
SHD2_k127_5387423_7 Biotin carboxylase C-terminal domain K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 1.684e-223 703.0
SHD2_k127_5387423_70 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000005575 236.0
SHD2_k127_5387423_71 Redoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000002855 236.0
SHD2_k127_5387423_72 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000002977 238.0
SHD2_k127_5387423_73 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000003043 218.0
SHD2_k127_5387423_74 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000001546 216.0
SHD2_k127_5387423_75 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000000000000000000009994 215.0
SHD2_k127_5387423_76 Uncharacterized protein family (UPF0051) K09015 - - 0.000000000000000000000000000000000000000000000000000000000003512 223.0
SHD2_k127_5387423_77 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000009171 209.0
SHD2_k127_5387423_78 transcriptional regulator K13643 - - 0.00000000000000000000000000000000000000000000000000000000009341 209.0
SHD2_k127_5387423_79 YdjC-like protein K03478 - 3.5.1.105 0.0000000000000000000000000000000000000000000000000000000001989 220.0
SHD2_k127_5387423_8 Ethanolamine ammonia-lyase large subunit K03735 - 4.3.1.7 3.08e-223 702.0
SHD2_k127_5387423_80 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000003447 215.0
SHD2_k127_5387423_81 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000006387 190.0
SHD2_k127_5387423_82 SURF1 family K14998 - - 0.0000000000000000000000000000000000000000000000002049 184.0
SHD2_k127_5387423_83 NADH ubiquinone oxidoreductase 17.2 kD subunit - - - 0.000000000000000000000000000000000000000000000002212 176.0
SHD2_k127_5387423_84 Belongs to the HesB IscA family K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000006823 175.0
SHD2_k127_5387423_85 iron-sulfur transferase activity K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.00000000000000000000000000000000000000000000001536 174.0
SHD2_k127_5387423_86 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000002161 183.0
SHD2_k127_5387423_87 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K01487,K11991 - 3.5.4.1,3.5.4.3,3.5.4.33 0.0000000000000000000000000000000000000000000002663 184.0
SHD2_k127_5387423_88 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000003431 169.0
SHD2_k127_5387423_89 Iron-sulfur cluster assembly protein - - - 0.000000000000000000000000000000000000000000001052 169.0
SHD2_k127_5387423_9 peptidase M13 K07386 - - 9.093e-223 710.0
SHD2_k127_5387423_90 Protein of unknown function (DUF1203) - - - 0.00000000000000000000000000000000000000000005811 164.0
SHD2_k127_5387423_91 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000000004655 162.0
SHD2_k127_5387423_92 MlaD protein K02067 - - 0.000000000000000000000000000000000000009791 151.0
SHD2_k127_5387423_93 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000009202 148.0
SHD2_k127_5387423_94 DoxX K15977 - - 0.00000000000000000000000000000000003884 139.0
SHD2_k127_5387423_95 Protein of unknown function (DUF983) - - - 0.0000000000000000000000000000000001504 135.0
SHD2_k127_5387423_96 Dsba oxidoreductase - - - 0.000000000000000000000000000000002725 139.0
SHD2_k127_5387423_97 Domain of unknown function (DUF4170) - - - 0.0000000000000000000000000000009708 125.0
SHD2_k127_5387423_98 CDGSH-type zinc finger. Function unknown. - - - 0.000000000000000000000000000001824 124.0
SHD2_k127_5387423_99 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000011 111.0
SHD2_k127_5412153_0 S-adenosylmethionine diacylglycerol 3-amino-3-carboxypropyl transferase K13622 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 452.0
SHD2_k127_5412153_1 Thioesterase-like superfamily K10805 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 380.0
SHD2_k127_5412153_2 Putative methyltransferase K13623 - - 0.00000000000000000000000000000000000000000000000000000009386 205.0
SHD2_k127_5484590_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2147.0
SHD2_k127_5484590_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046,K13797 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2075.0
SHD2_k127_5484590_10 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000001294 216.0
SHD2_k127_5484590_11 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000000000007195 183.0
SHD2_k127_5484590_12 MAPEG family - - - 0.00000000000000000000000000000000000000000000005285 174.0
SHD2_k127_5484590_13 nUDIX hydrolase K01518,K08296 - 3.6.1.17 0.0000000000000000000000000000000000001856 147.0
SHD2_k127_5484590_14 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000001232 115.0
SHD2_k127_5484590_15 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000001209 90.0
SHD2_k127_5484590_16 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000009485 82.0
SHD2_k127_5484590_17 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00000000000000005309 83.0
SHD2_k127_5484590_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1055.0
SHD2_k127_5484590_3 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006497 346.0
SHD2_k127_5484590_4 In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold. K02601 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003982 265.0
SHD2_k127_5484590_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000182 256.0
SHD2_k127_5484590_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000003344 233.0
SHD2_k127_5484590_7 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000005182 231.0
SHD2_k127_5484590_8 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000002618 224.0
SHD2_k127_5484590_9 Enoyl-CoA hydratase isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000008632 221.0
SHD2_k127_5528193_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 6.431e-217 681.0
SHD2_k127_5528193_1 Penicillin-binding protein 2 K05515 - 3.4.16.4 2.43e-203 659.0
SHD2_k127_5528193_10 Maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003083 274.0
SHD2_k127_5528193_11 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000001642 213.0
SHD2_k127_5528193_12 PFAM Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000001004 196.0
SHD2_k127_5528193_13 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000000000002432 189.0
SHD2_k127_5528193_14 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000004183 151.0
SHD2_k127_5528193_15 Copper chaperone PCu(A)C K09796 - - 0.00000000000000000000001991 111.0
SHD2_k127_5528193_16 - - - - 0.0000000000000000001274 95.0
SHD2_k127_5528193_17 Copper resistance protein D K07245 - - 0.0000000000000002143 90.0
SHD2_k127_5528193_18 shape-determining protein K03571 - - 0.000000000000009863 81.0
SHD2_k127_5528193_19 Copper resistance protein K07156 - - 0.00000000000009376 81.0
SHD2_k127_5528193_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 6.273e-198 638.0
SHD2_k127_5528193_3 Rod shape-determining protein (MreB) K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 591.0
SHD2_k127_5528193_4 Homogentisate 1,2-dioxygenase K00451 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004411,GO:0005488,GO:0005506,GO:0005575,GO:0006082,GO:0006355,GO:0006520,GO:0006558,GO:0006559,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0019219,GO:0019222,GO:0019439,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051213,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 1.13.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 557.0
SHD2_k127_5528193_5 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 536.0
SHD2_k127_5528193_6 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 536.0
SHD2_k127_5528193_7 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 460.0
SHD2_k127_5528193_8 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 413.0
SHD2_k127_5528193_9 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 306.0
SHD2_k127_5531722_0 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 1.903e-243 771.0
SHD2_k127_5531722_1 elongation factor G K02355 - - 2.331e-241 764.0
SHD2_k127_5531722_10 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 319.0
SHD2_k127_5531722_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007714 281.0
SHD2_k127_5531722_12 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002768 266.0
SHD2_k127_5531722_13 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000003334 271.0
SHD2_k127_5531722_14 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007109 268.0
SHD2_k127_5531722_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005634 252.0
SHD2_k127_5531722_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001551 251.0
SHD2_k127_5531722_17 Transcriptional - GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000009827 213.0
SHD2_k127_5531722_18 TPM domain - - - 0.00000000000000000000000000000000000000000000000000003208 201.0
SHD2_k127_5531722_19 Putative member of DMT superfamily (DUF486) K09922 - - 0.000000000000000000000000000000000000000001803 160.0
SHD2_k127_5531722_2 Major Facilitator - - - 6.404e-210 666.0
SHD2_k127_5531722_20 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000001658 141.0
SHD2_k127_5531722_21 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000001969 132.0
SHD2_k127_5531722_22 - - - - 0.000000000000000000000001261 108.0
SHD2_k127_5531722_23 Lipid A Biosynthesis N-terminal domain - - - 0.0000000000000000000004236 103.0
SHD2_k127_5531722_24 CVNH domain - - - 0.00000000000000002774 87.0
SHD2_k127_5531722_25 PAS domain - - - 0.00000000000000007492 88.0
SHD2_k127_5531722_26 membrane K08988 - - 0.0000000000000135 84.0
SHD2_k127_5531722_27 - - - - 0.0000000003606 69.0
SHD2_k127_5531722_3 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 8.984e-203 637.0
SHD2_k127_5531722_4 lysine 2,3-aminomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 593.0
SHD2_k127_5531722_5 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 452.0
SHD2_k127_5531722_6 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004081 444.0
SHD2_k127_5531722_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 386.0
SHD2_k127_5531722_8 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 370.0
SHD2_k127_5531722_9 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006054 337.0
SHD2_k127_5638979_0 AcrB/AcrD/AcrF family - - - 0.0 1517.0
SHD2_k127_5638979_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 406.0
SHD2_k127_5638979_2 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000001131 126.0
SHD2_k127_5717227_0 DDE superfamily endonuclease - - - 1.106e-215 676.0
SHD2_k127_5717227_1 Transposase domain (DUF772) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 516.0
SHD2_k127_5717227_2 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005534 427.0
SHD2_k127_5717227_3 DDE superfamily endonuclease - - - 0.000004739 52.0
SHD2_k127_5858187_0 PFAM peptidase M3A and M3B thimet oligopeptidase F K01284 GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.5 3.092e-244 771.0
SHD2_k127_5858187_1 oligoendopeptidase F K08602 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 621.0
SHD2_k127_5858187_2 Peptide ABC transporter substrate-binding protein K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 404.0
SHD2_k127_5858187_3 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000003301 246.0
SHD2_k127_5858187_4 Resolvase, N terminal domain K06400 - - 0.0000000000000000000000000000000000000000000000000000000000005513 217.0
SHD2_k127_5858187_5 Thioredoxin-like - - - 0.000000000000000000000000000000000000000000000000004265 192.0
SHD2_k127_5858187_6 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000001319 167.0
SHD2_k127_5858187_7 SBF-like CPA transporter family (DUF4137) K14347 - - 0.00000000000000000000000000000000002051 137.0
SHD2_k127_6029072_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 562.0
SHD2_k127_6029072_1 Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA K18383 - 4.1.2.41,4.2.1.101 0.00000000000000000000000000000000000000000000000000000000001216 209.0
SHD2_k127_6029072_2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.0000000000000000000000000000000000000000000000000000000001182 214.0
SHD2_k127_6036018_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 7.238e-232 733.0
SHD2_k127_6036018_1 Glutathione S-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005712 310.0
SHD2_k127_6036018_2 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.00000000000000000000000000000000003513 138.0
SHD2_k127_6195106_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1095.0
SHD2_k127_6195106_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 1.206e-285 890.0
SHD2_k127_6195106_10 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 467.0
SHD2_k127_6195106_11 N-terminal domain of oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 449.0
SHD2_k127_6195106_12 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 444.0
SHD2_k127_6195106_13 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006122 449.0
SHD2_k127_6195106_14 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 435.0
SHD2_k127_6195106_15 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 382.0
SHD2_k127_6195106_16 Repeat of Unknown Function (DUF347) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 385.0
SHD2_k127_6195106_17 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 338.0
SHD2_k127_6195106_18 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 332.0
SHD2_k127_6195106_19 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009476 321.0
SHD2_k127_6195106_2 receptor - - - 4.064e-275 869.0
SHD2_k127_6195106_20 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005081 304.0
SHD2_k127_6195106_21 Lipoprotein-releasing system ATP-binding protein LolD K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 295.0
SHD2_k127_6195106_22 L,D-transpeptidase catalytic domain K21470,K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008872 289.0
SHD2_k127_6195106_23 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001011 270.0
SHD2_k127_6195106_24 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000001175 251.0
SHD2_k127_6195106_25 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007184 229.0
SHD2_k127_6195106_26 Bacterial protein of unknown function (DUF882) - - - 0.000000000000000000000000000000000000000000000000007281 186.0
SHD2_k127_6195106_27 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.0000000000000000000000000000000000000000000003546 171.0
SHD2_k127_6195106_28 Integral membrane protein (intg_mem_TP0381) - - - 0.000000000000000000000000000000000000003708 155.0
SHD2_k127_6195106_29 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000000000000001461 143.0
SHD2_k127_6195106_3 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.252e-256 805.0
SHD2_k127_6195106_30 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000001141 135.0
SHD2_k127_6195106_31 Cytochrome c - - - 0.000000000000000000000000003666 114.0
SHD2_k127_6195106_32 - - - - 0.00000000000000000000000002628 117.0
SHD2_k127_6195106_33 - - - - 0.00000000000000000000001268 103.0
SHD2_k127_6195106_34 GCN5-related N-acetyl-transferase K06975 - - 0.00000000000000000000003491 108.0
SHD2_k127_6195106_35 Cation transport regulator K06197 - - 0.00000000000000000000003578 101.0
SHD2_k127_6195106_4 Sulfotransferase - - - 1.993e-243 769.0
SHD2_k127_6195106_5 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K18688 - 6.2.1.42 4.824e-238 746.0
SHD2_k127_6195106_6 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 9.339e-225 719.0
SHD2_k127_6195106_7 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 578.0
SHD2_k127_6195106_8 P-aminobenzoate N-oxygenase AurF - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 556.0
SHD2_k127_6195106_9 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 552.0
SHD2_k127_6212672_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 1.43e-322 991.0
SHD2_k127_6212672_1 RES - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008237 350.0
SHD2_k127_6212672_2 IS66 Orf2 K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003432 243.0
SHD2_k127_6212672_3 Transposase K07483 - - 0.000000000000000000000000000000000000000000000000000000000000000004758 227.0
SHD2_k127_6212672_4 - - - - 0.00000000000000000000000000000000000000000000000000001872 189.0
SHD2_k127_6300536_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 3.878e-259 802.0
SHD2_k127_6300536_1 Transposase DDE domain - - - 3.077e-198 627.0
SHD2_k127_6300536_2 ABC transporter substrate binding protein - - - 0.000000000000000000007998 93.0
SHD2_k127_6352745_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 3193.0
SHD2_k127_6352745_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1157.0
SHD2_k127_6352745_10 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 9.645e-265 828.0
SHD2_k127_6352745_101 PilZ domain - - - 0.0000000000159 68.0
SHD2_k127_6352745_102 - - - - 0.0000000001321 67.0
SHD2_k127_6352745_103 - - - - 0.000000005736 60.0
SHD2_k127_6352745_104 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000001082 59.0
SHD2_k127_6352745_105 methyltransferase - - - 0.00000004684 57.0
SHD2_k127_6352745_106 - - - - 0.000002502 54.0
SHD2_k127_6352745_107 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000004191 61.0
SHD2_k127_6352745_108 Belongs to the ompA family - - - 0.00003012 50.0
SHD2_k127_6352745_11 Aldehyde dehydrogenase family K00140 GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896 1.2.1.18,1.2.1.27 1.416e-263 822.0
SHD2_k127_6352745_12 CHAT domain - - - 2.946e-261 839.0
SHD2_k127_6352745_13 belongs to the aldehyde dehydrogenase family - - - 3.835e-252 782.0
SHD2_k127_6352745_14 mannose metabolic process K01191 - 3.2.1.24 1.85e-237 769.0
SHD2_k127_6352745_15 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 9.421e-218 687.0
SHD2_k127_6352745_16 acyl-CoA dehydrogenase K00249,K06446 - 1.3.8.7 8.333e-215 671.0
SHD2_k127_6352745_17 Alkyl sulfatase dimerisation - - - 3.022e-214 681.0
SHD2_k127_6352745_18 Belongs to the thiolase family K00626 - 2.3.1.9 6.177e-211 665.0
SHD2_k127_6352745_19 - - - - 1.063e-202 634.0
SHD2_k127_6352745_2 Vitamin B12 dependent methionine synthase, activation domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1120.0
SHD2_k127_6352745_20 Alcohol dehydrogenase GroES-like domain K00001,K00055,K00121 - 1.1.1.1,1.1.1.284,1.1.1.90 4.07e-196 615.0
SHD2_k127_6352745_21 Protein of unknown function (DUF2961) - - - 5.871e-196 616.0
SHD2_k127_6352745_22 AMP-binding enzyme C-terminal domain K15868 - 6.2.1.7 2.969e-194 617.0
SHD2_k127_6352745_23 4-coumarate--CoA - - - 8.887e-194 617.0
SHD2_k127_6352745_24 Cytochrome P450 K15877 - 1.7.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 611.0
SHD2_k127_6352745_25 Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006284 601.0
SHD2_k127_6352745_26 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K18334 - 4.2.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 589.0
SHD2_k127_6352745_27 CHASE2 K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 602.0
SHD2_k127_6352745_28 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 585.0
SHD2_k127_6352745_29 Alcohol dehydrogenase GroES-like domain K00055 - 1.1.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 569.0
SHD2_k127_6352745_3 Belongs to the enoyl-CoA hydratase isomerase family K00022,K07514 - 1.1.1.35,4.2.1.17,5.3.3.8 0.0 1104.0
SHD2_k127_6352745_30 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 531.0
SHD2_k127_6352745_31 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005379 531.0
SHD2_k127_6352745_32 Phosphofructokinase K00850,K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009987 517.0
SHD2_k127_6352745_33 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008573 519.0
SHD2_k127_6352745_34 Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 512.0
SHD2_k127_6352745_35 fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 485.0
SHD2_k127_6352745_36 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 489.0
SHD2_k127_6352745_37 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 466.0
SHD2_k127_6352745_38 COG2070 Dioxygenases related to 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008157 464.0
SHD2_k127_6352745_39 Thioesterase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 469.0
SHD2_k127_6352745_4 Molydopterin dinucleotide binding domain K00123,K05299 - 1.17.1.10,1.17.1.9 0.0 1079.0
SHD2_k127_6352745_40 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009776 447.0
SHD2_k127_6352745_41 COG3552 Protein containing von Willebrand factor type A (vWA) domain K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 444.0
SHD2_k127_6352745_42 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 434.0
SHD2_k127_6352745_43 AAA ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007986 437.0
SHD2_k127_6352745_44 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 433.0
SHD2_k127_6352745_45 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 430.0
SHD2_k127_6352745_46 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 411.0
SHD2_k127_6352745_47 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 417.0
SHD2_k127_6352745_48 Enoyl-CoA hydratase/isomerase K01692,K05605 - 3.1.2.4,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 414.0
SHD2_k127_6352745_49 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 399.0
SHD2_k127_6352745_5 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 5.734e-309 957.0
SHD2_k127_6352745_50 Methylenetetrahydrofolate reductase K00297 GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 402.0
SHD2_k127_6352745_51 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 403.0
SHD2_k127_6352745_52 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 384.0
SHD2_k127_6352745_53 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 380.0
SHD2_k127_6352745_54 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 375.0
SHD2_k127_6352745_55 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 360.0
SHD2_k127_6352745_56 Nitronate monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 351.0
SHD2_k127_6352745_57 KR domain K00218 - 1.3.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 355.0
SHD2_k127_6352745_58 TIGRFAM hopanoid biosynthesis associated protein HpnK K03478 - 3.5.1.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 344.0
SHD2_k127_6352745_59 Domain of unknown function (DUF1794) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 340.0
SHD2_k127_6352745_6 Flavoprotein involved in K transport - - - 1.13e-285 881.0
SHD2_k127_6352745_60 MFS/sugar transport protein K03292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006485 349.0
SHD2_k127_6352745_61 Phytoene synthase K21678 - 2.5.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 338.0
SHD2_k127_6352745_62 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 335.0
SHD2_k127_6352745_63 Hopanoid biosynthesis associated glycosyl transferase protein HpnI K00720 - 2.4.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 336.0
SHD2_k127_6352745_64 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 332.0
SHD2_k127_6352745_65 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 327.0
SHD2_k127_6352745_66 Squalene/phytoene synthase K21679 - 4.2.3.156 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 332.0
SHD2_k127_6352745_67 Belongs to the GST superfamily K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 317.0
SHD2_k127_6352745_68 short-chain dehydrogenase K05296 - 1.1.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 318.0
SHD2_k127_6352745_69 Amidohydrolase K07046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 318.0
SHD2_k127_6352745_7 ABC transporter K15738 - - 8.859e-283 877.0
SHD2_k127_6352745_70 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009908 312.0
SHD2_k127_6352745_71 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 306.0
SHD2_k127_6352745_72 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004549 272.0
SHD2_k127_6352745_73 MlaA lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000001032 220.0
SHD2_k127_6352745_74 MlaA lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000002088 212.0
SHD2_k127_6352745_75 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000002293 196.0
SHD2_k127_6352745_76 - - - - 0.00000000000000000000000000000000000000000000000000136 198.0
SHD2_k127_6352745_77 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000003616 190.0
SHD2_k127_6352745_78 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000009637 174.0
SHD2_k127_6352745_79 hopanoid biosynthesis associated membrane protein HpnM K07323 - - 0.0000000000000000000000000000000000000000001708 168.0
SHD2_k127_6352745_8 MMPL family K07003 - - 2.699e-268 851.0
SHD2_k127_6352745_80 transmembrane transport - - - 0.00000000000000000000000000000000000000002484 170.0
SHD2_k127_6352745_81 Domain of unknown function (DUF1992) - - - 0.000000000000000000000000000000000000004482 152.0
SHD2_k127_6352745_82 Thioesterase superfamily - - - 0.000000000000000000000000000000000000009824 152.0
SHD2_k127_6352745_83 Protein of unknown function (DUF992) - - - 0.00000000000000000000000000000000000001523 151.0
SHD2_k127_6352745_84 L-rhamnose mutarotase K03534 - 5.1.3.32 0.0000000000000000000000000000000000001202 145.0
SHD2_k127_6352745_85 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000001212 147.0
SHD2_k127_6352745_86 PFAM purine or other phosphorylase family 1 - - - 0.000000000000000000000000000000000004501 148.0
SHD2_k127_6352745_87 Biopolymer transport protein ExbD/TolR K03559 - - 0.00000000000000000000000000000000002562 138.0
SHD2_k127_6352745_88 Alpha beta hydrolase - - - 0.0000000000000000000000000000000002671 142.0
SHD2_k127_6352745_89 MlaC protein K07323 - - 0.000000000000000000000000000000001044 139.0
SHD2_k127_6352745_9 hopanoid biosynthesis associated radical SAM protein HpnJ - - - 1.77e-266 824.0
SHD2_k127_6352745_90 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000002661 138.0
SHD2_k127_6352745_91 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000001581 134.0
SHD2_k127_6352745_92 Protein of unknown function (DUF3307) - - - 0.00000000000000000000000001676 114.0
SHD2_k127_6352745_93 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000009536 121.0
SHD2_k127_6352745_94 Glycine zipper 2TM domain - - - 0.000000000000000000000006149 109.0
SHD2_k127_6352745_95 'PFAM Response regulator receiver - - - 0.00000000000000000000002165 107.0
SHD2_k127_6352745_96 PFAM type IV pilus assembly PilZ - - - 0.0000000000000002126 88.0
SHD2_k127_6352745_97 Membrane - - - 0.0000000000000008313 87.0
SHD2_k127_6352745_98 - - - - 0.00000000000003001 78.0
SHD2_k127_637112_0 Transposase - - - 1.959e-246 763.0
SHD2_k127_637112_1 Integrase core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 321.0
SHD2_k127_637112_2 - - - - 0.0000000000000008973 83.0
SHD2_k127_6382739_0 CoA binding domain - - - 2.719e-213 683.0
SHD2_k127_6382739_1 Enoyl-CoA hydratase/isomerase K18383 - 4.1.2.41,4.2.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002847 444.0
SHD2_k127_6382739_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001945 276.0
SHD2_k127_6382739_3 YCII-related domain K09780 - - 0.0000000000000000000000004487 107.0
SHD2_k127_6382739_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000004076 102.0
SHD2_k127_6400575_0 DNA polymerase alpha chain like domain K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1260.0
SHD2_k127_6400575_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1188.0
SHD2_k127_6400575_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 1.043e-224 704.0
SHD2_k127_6400575_11 Belongs to the citrate synthase family K01647 - 2.3.3.1 3.952e-222 696.0
SHD2_k127_6400575_12 belongs to the aldehyde dehydrogenase family K00154,K22445 - 1.2.1.68,1.2.99.10 2.506e-219 689.0
SHD2_k127_6400575_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 2.249e-215 679.0
SHD2_k127_6400575_14 Metallo-beta-lactamase superfamily K12574 - - 2.652e-199 638.0
SHD2_k127_6400575_15 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 612.0
SHD2_k127_6400575_16 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005657 578.0
SHD2_k127_6400575_17 acetyl-coa acetyltransferase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 579.0
SHD2_k127_6400575_18 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 554.0
SHD2_k127_6400575_19 Carbohydrate family 9 binding domain-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005035 574.0
SHD2_k127_6400575_2 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.029e-290 908.0
SHD2_k127_6400575_20 Belongs to the DEAD box helicase family K03732,K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005803 546.0
SHD2_k127_6400575_21 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 506.0
SHD2_k127_6400575_22 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 510.0
SHD2_k127_6400575_23 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 499.0
SHD2_k127_6400575_24 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 497.0
SHD2_k127_6400575_25 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 492.0
SHD2_k127_6400575_26 Competence protein K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 498.0
SHD2_k127_6400575_27 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 474.0
SHD2_k127_6400575_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 453.0
SHD2_k127_6400575_29 PFAM aminoglycoside phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 452.0
SHD2_k127_6400575_3 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 3.338e-280 882.0
SHD2_k127_6400575_30 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 456.0
SHD2_k127_6400575_31 Aspartate tyrosine aromatic aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 432.0
SHD2_k127_6400575_32 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 431.0
SHD2_k127_6400575_33 KR domain K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000397 419.0
SHD2_k127_6400575_34 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 419.0
SHD2_k127_6400575_35 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 429.0
SHD2_k127_6400575_36 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 395.0
SHD2_k127_6400575_37 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 399.0
SHD2_k127_6400575_38 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 377.0
SHD2_k127_6400575_39 Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 379.0
SHD2_k127_6400575_4 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 8.202e-267 836.0
SHD2_k127_6400575_40 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 368.0
SHD2_k127_6400575_41 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009258 359.0
SHD2_k127_6400575_42 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006104 364.0
SHD2_k127_6400575_43 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 360.0
SHD2_k127_6400575_44 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 339.0
SHD2_k127_6400575_45 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 340.0
SHD2_k127_6400575_46 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 325.0
SHD2_k127_6400575_47 Belongs to the TrpC family K01609,K13498 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006367 320.0
SHD2_k127_6400575_48 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 306.0
SHD2_k127_6400575_49 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 298.0
SHD2_k127_6400575_5 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 7.197e-254 796.0
SHD2_k127_6400575_50 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K03941 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 290.0
SHD2_k127_6400575_51 Anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003313 286.0
SHD2_k127_6400575_52 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 285.0
SHD2_k127_6400575_53 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001171 289.0
SHD2_k127_6400575_54 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001111 282.0
SHD2_k127_6400575_55 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003356 280.0
SHD2_k127_6400575_56 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007709 300.0
SHD2_k127_6400575_57 COG2199 FOG GGDEF domain K07216,K13590 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002159 284.0
SHD2_k127_6400575_58 Domain of unknown function (DUF3291) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001177 258.0
SHD2_k127_6400575_59 PFAM Fatty acid hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000184 267.0
SHD2_k127_6400575_6 glutamine synthetase K01915 - 6.3.1.2 9.584e-239 744.0
SHD2_k127_6400575_60 Udp N-acetylglucosamine O-acyltransferase; Domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004855 264.0
SHD2_k127_6400575_61 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000191 259.0
SHD2_k127_6400575_62 protein conserved in bacteria K09949 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000000000000000000000000000000000000000000000000000000303 253.0
SHD2_k127_6400575_63 PFAM ATP-binding region ATPase domain protein K07716 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000002722 259.0
SHD2_k127_6400575_64 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000001156 239.0
SHD2_k127_6400575_65 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000001813 237.0
SHD2_k127_6400575_66 methylmalonyl-CoA epimerase K05606 - 5.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000002905 233.0
SHD2_k127_6400575_67 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000005029 250.0
SHD2_k127_6400575_68 Thioredoxin-like [2Fe-2S] ferredoxin K00334,K03943 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000008865 235.0
SHD2_k127_6400575_69 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000006478 218.0
SHD2_k127_6400575_7 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 9.981e-236 753.0
SHD2_k127_6400575_70 FR47-like protein - - - 0.00000000000000000000000000000000000000000000000000000000002696 215.0
SHD2_k127_6400575_71 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.000000000000000000000000000000000000000000000000000000001499 201.0
SHD2_k127_6400575_72 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000603 195.0
SHD2_k127_6400575_73 Acetyltransferase (GNAT) domain K03823 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 2.3.1.183 0.0000000000000000000000000000000000000000000000000000119 193.0
SHD2_k127_6400575_74 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000000000000002068 188.0
SHD2_k127_6400575_75 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000004709 187.0
SHD2_k127_6400575_76 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000004791 181.0
SHD2_k127_6400575_77 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000002658 163.0
SHD2_k127_6400575_78 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000000000000000008662 164.0
SHD2_k127_6400575_79 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000006303 158.0
SHD2_k127_6400575_8 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 2.322e-234 736.0
SHD2_k127_6400575_80 Aminoglycoside/hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.000000000000000000000000000000000002304 151.0
SHD2_k127_6400575_81 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000000000000000000000000000005417 148.0
SHD2_k127_6400575_82 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000002055 119.0
SHD2_k127_6400575_83 membrane - - - 0.0000000000000000006342 99.0
SHD2_k127_6400575_84 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000006971 75.0
SHD2_k127_6400575_85 unfolded protein binding K06142 - - 0.00000000004435 72.0
SHD2_k127_6400575_86 - - - - 0.0000000004006 61.0
SHD2_k127_6400575_87 Protein of unknown function (DUF1467) - - - 0.00000000304 61.0
SHD2_k127_6400575_88 Ca2 -binding protein (EF-Hand superfamily - - - 0.00000001839 64.0
SHD2_k127_6400575_89 lactoylglutathione lyase activity K00941,K01724,K01759,K07032,K08234 - 2.7.1.49,2.7.4.7,4.2.1.96,4.4.1.5 0.0000001827 59.0
SHD2_k127_6400575_9 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 4.984e-227 708.0
SHD2_k127_6400575_90 MSS3 MSS3 (multicopy suppressors of snf4 deficiency in yeast 3) K13448 GO:0003674,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0010008,GO:0012505,GO:0016020,GO:0016021,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031302,GO:0031303,GO:0031410,GO:0031982,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044440,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0097708,GO:0098588,GO:0098805 - 0.000004993 55.0
SHD2_k127_647371_0 cytochrome P450 K21034 - - 6.424e-235 732.0
SHD2_k127_647371_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 300.0
SHD2_k127_647371_2 - - - - 0.00000000000000000000000000001342 123.0
SHD2_k127_647371_3 Rubrerythrin - - - 0.000000000000000000000001602 108.0
SHD2_k127_647371_4 PFAM Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000001265 64.0
SHD2_k127_6517658_0 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 479.0
SHD2_k127_6517658_1 Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA K18383 - 4.1.2.41,4.2.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 353.0
SHD2_k127_6517658_2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000000000000000000000000000000000000002829 171.0
SHD2_k127_6517658_3 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000000000000000000000000000000000004337 161.0
SHD2_k127_6517658_4 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000005587 98.0
SHD2_k127_6520840_0 PQQ enzyme repeat K17760 - 1.1.9.1 1.947e-232 741.0
SHD2_k127_6520840_1 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 530.0
SHD2_k127_6520840_10 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 354.0
SHD2_k127_6520840_11 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 339.0
SHD2_k127_6520840_12 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 335.0
SHD2_k127_6520840_13 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 317.0
SHD2_k127_6520840_14 Histidyl-tRNA synthetase K02502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 317.0
SHD2_k127_6520840_16 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003658 277.0
SHD2_k127_6520840_17 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000001501 270.0
SHD2_k127_6520840_18 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000003065 262.0
SHD2_k127_6520840_19 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000393 243.0
SHD2_k127_6520840_2 4Fe-4S double cluster binding domain K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005457 482.0
SHD2_k127_6520840_20 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001176 226.0
SHD2_k127_6520840_21 NIPSNAP - - - 0.0000000000000000000000000000000000000000000000000000000000001111 224.0
SHD2_k127_6520840_22 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000004881 204.0
SHD2_k127_6520840_23 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000004636 170.0
SHD2_k127_6520840_24 Putative heavy-metal-binding - - - 0.0000000000000000000000000000000000000000000009531 167.0
SHD2_k127_6520840_25 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000002011 169.0
SHD2_k127_6520840_26 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000008454 153.0
SHD2_k127_6520840_27 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000001204 146.0
SHD2_k127_6520840_28 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000000000182 144.0
SHD2_k127_6520840_29 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000121 146.0
SHD2_k127_6520840_3 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 473.0
SHD2_k127_6520840_30 Ring hydroxylating beta subunit K16320 - 1.14.12.1 0.000000000000000000000000002442 119.0
SHD2_k127_6520840_31 - - - - 0.00000000001688 68.0
SHD2_k127_6520840_32 Flp pilus assembly protein, pilin Flp K02651 - - 0.00000000009285 64.0
SHD2_k127_6520840_4 Rieske 2Fe-2S domain protein K16319,K18242 - 1.14.12.1,1.14.13.172 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 455.0
SHD2_k127_6520840_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 450.0
SHD2_k127_6520840_6 Gentisate 1,2-dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 396.0
SHD2_k127_6520840_7 Zn-dependent protease with chaperone function K03799,K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 397.0
SHD2_k127_6520840_8 4-hydroxy-tetrahydrodipicolinate synthase K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 381.0
SHD2_k127_6520840_9 cytochrome P450 K15468 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 385.0
SHD2_k127_6523798_0 Belongs to the peptidase S16 family - - - 2.371e-242 773.0
SHD2_k127_6523798_1 Alanine dehydrogenase/PNT, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008755 256.0
SHD2_k127_6523798_2 - - - - 0.0000000000000000000002712 107.0
SHD2_k127_6551240_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1404.0
SHD2_k127_6551240_1 Catalyzes the synthesis of activated sulfate K00955 - 2.7.1.25,2.7.7.4 0.0 1004.0
SHD2_k127_6551240_10 Acyl-CoA synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 484.0
SHD2_k127_6551240_11 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007918 462.0
SHD2_k127_6551240_12 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009754 358.0
SHD2_k127_6551240_13 Aspartyl protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 351.0
SHD2_k127_6551240_14 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 319.0
SHD2_k127_6551240_15 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 313.0
SHD2_k127_6551240_16 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 294.0
SHD2_k127_6551240_17 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003128 270.0
SHD2_k127_6551240_18 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001675 243.0
SHD2_k127_6551240_19 Phosphotriesterase family K07048 - - 0.00000000000000000000000000000000000000000000000000000000000000001903 237.0
SHD2_k127_6551240_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 1.842e-285 892.0
SHD2_k127_6551240_20 ABC transporter K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000007885 224.0
SHD2_k127_6551240_21 Protein of unknown function (DUF2914) - - - 0.00000000000000000000000000000000000000000000000000005423 201.0
SHD2_k127_6551240_22 - - - - 0.000000000000000000000000000000000000000000000000002201 201.0
SHD2_k127_6551240_23 Protein of unknown function (DUF2585) - - - 0.00000000000000000000000000000000000000000000000004248 187.0
SHD2_k127_6551240_24 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - 0.000000000000000000000000000000000002479 139.0
SHD2_k127_6551240_25 Protein of unknown function (DUF3297) - - - 0.0000000000000000000000000000000001215 138.0
SHD2_k127_6551240_26 - - - - 0.000000000000000000000000000000004326 137.0
SHD2_k127_6551240_27 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000001809 111.0
SHD2_k127_6551240_28 Flavinator of succinate dehydrogenase K09159 - - 0.000000000000000001096 92.0
SHD2_k127_6551240_3 Acyl-CoA dehydrogenase N terminal - - - 2.808e-250 785.0
SHD2_k127_6551240_4 Thiolase, N-terminal domain K00626 - 2.3.1.9 2.767e-217 679.0
SHD2_k127_6551240_5 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 1.972e-196 620.0
SHD2_k127_6551240_6 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009294 578.0
SHD2_k127_6551240_7 metal-dependent hydrolase of the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 565.0
SHD2_k127_6551240_8 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes K00957 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005144 556.0
SHD2_k127_6551240_9 NAD(P)H-binding K15894 - 4.2.1.115 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 485.0
SHD2_k127_6639183_0 Transposase K07487 - - 5.666e-238 745.0
SHD2_k127_6639183_1 COG0339 Zn-dependent oligopeptidases K01284 GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 293.0
SHD2_k127_6656823_0 4-coumarate--CoA - - - 6.033e-284 885.0
SHD2_k127_6656823_1 Luciferase-like monooxygenase - - - 4.638e-229 714.0
SHD2_k127_6656823_10 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 361.0
SHD2_k127_6656823_11 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 350.0
SHD2_k127_6656823_12 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 336.0
SHD2_k127_6656823_13 Transcriptional regulatory protein, C terminal K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 306.0
SHD2_k127_6656823_14 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 307.0
SHD2_k127_6656823_15 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 291.0
SHD2_k127_6656823_16 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 290.0
SHD2_k127_6656823_17 Protein of unknown function (DUF861) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 283.0
SHD2_k127_6656823_18 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000227 273.0
SHD2_k127_6656823_19 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000001618 235.0
SHD2_k127_6656823_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 2.744e-207 652.0
SHD2_k127_6656823_20 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000005881 176.0
SHD2_k127_6656823_21 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.000000000000000000000000000000000000001312 151.0
SHD2_k127_6656823_22 phosphoglycerate mutase - - - 0.00000000000000000000000000004409 130.0
SHD2_k127_6656823_3 AlkA N-terminal domain K13529 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 615.0
SHD2_k127_6656823_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 541.0
SHD2_k127_6656823_5 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 545.0
SHD2_k127_6656823_6 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000577 476.0
SHD2_k127_6656823_7 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 475.0
SHD2_k127_6656823_8 MFS/sugar transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 414.0
SHD2_k127_6656823_9 MFS/sugar transport protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 393.0
SHD2_k127_6674884_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 4.67e-321 1014.0
SHD2_k127_6674884_1 Class II Aldolase and Adducin N-terminal domain - - - 3.25e-312 970.0
SHD2_k127_6674884_10 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00410,K00412 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007653 588.0
SHD2_k127_6674884_100 Flagellar hook-length control protein FliK K10565 - - 0.000000000000000000001012 110.0
SHD2_k127_6674884_101 Flagellar assembly protein FliH K02411 - - 0.00000000000000000002415 99.0
SHD2_k127_6674884_102 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.00000000000000000006274 96.0
SHD2_k127_6674884_103 TIGRFAM flagellar export protein FliJ - - - 0.0000000000000000006177 91.0
SHD2_k127_6674884_104 - - - - 0.000000000000000008043 84.0
SHD2_k127_6674884_105 Membrane fusogenic activity K09806 - - 0.0000000000000001415 86.0
SHD2_k127_6674884_106 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000002505 78.0
SHD2_k127_6674884_107 - - - - 0.0000000000001615 77.0
SHD2_k127_6674884_108 - - - - 0.000000000004499 72.0
SHD2_k127_6674884_109 Peptidase family M48 - - - 0.000000000006524 78.0
SHD2_k127_6674884_11 flagellum-specific ATP synthase K02412 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000411 567.0
SHD2_k127_6674884_110 PFAM DoxX family protein K15977 - - 0.000000000009018 71.0
SHD2_k127_6674884_111 flagellar K02404 - - 0.00000000007689 73.0
SHD2_k127_6674884_112 - - - - 0.0000000009469 65.0
SHD2_k127_6674884_113 TIGRFAM Flagellar hook-associated protein 3 K02397 GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0000002636 62.0
SHD2_k127_6674884_114 YjbR - - - 0.0000008032 55.0
SHD2_k127_6674884_115 membrane protein (DUF2078) K08982 - - 0.000002063 53.0
SHD2_k127_6674884_116 - - - - 0.0001243 51.0
SHD2_k127_6674884_117 Protein of unknown function (DUF1192) - - - 0.0003713 51.0
SHD2_k127_6674884_118 - - - - 0.0004643 49.0
SHD2_k127_6674884_119 periplasmic protein - - - 0.000672 51.0
SHD2_k127_6674884_12 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008825 557.0
SHD2_k127_6674884_120 YjbR - - - 0.0007445 47.0
SHD2_k127_6674884_13 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 575.0
SHD2_k127_6674884_14 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 499.0
SHD2_k127_6674884_15 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000504 489.0
SHD2_k127_6674884_16 Saccharopine dehydrogenase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 484.0
SHD2_k127_6674884_17 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 485.0
SHD2_k127_6674884_18 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 470.0
SHD2_k127_6674884_19 Probable RNA and SrmB- binding site of polymerase A K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 465.0
SHD2_k127_6674884_2 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 8.241e-293 913.0
SHD2_k127_6674884_20 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009428 448.0
SHD2_k127_6674884_21 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 451.0
SHD2_k127_6674884_22 Predicted membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 460.0
SHD2_k127_6674884_23 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 456.0
SHD2_k127_6674884_24 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003621 449.0
SHD2_k127_6674884_25 With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine K02556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006326 423.0
SHD2_k127_6674884_26 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009866 427.0
SHD2_k127_6674884_27 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 417.0
SHD2_k127_6674884_28 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007626 415.0
SHD2_k127_6674884_29 The M ring may be actively involved in energy transduction K02409 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009431 427.0
SHD2_k127_6674884_3 COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K02182 - 6.2.1.48 7.065e-272 849.0
SHD2_k127_6674884_30 ATPase AAA K03924 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 415.0
SHD2_k127_6674884_31 Belongs to the flagella basal body rod proteins family K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 430.0
SHD2_k127_6674884_32 Transcriptional regulatory protein, C terminal K02483,K13584 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 404.0
SHD2_k127_6674884_33 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 430.0
SHD2_k127_6674884_34 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 387.0
SHD2_k127_6674884_35 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 385.0
SHD2_k127_6674884_36 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07638 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 390.0
SHD2_k127_6674884_37 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 - 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 381.0
SHD2_k127_6674884_38 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 355.0
SHD2_k127_6674884_39 Putative S-adenosyl-L-methionine-dependent methyltransferase K00574,K18164 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 342.0
SHD2_k127_6674884_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 2.882e-266 834.0
SHD2_k127_6674884_40 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 323.0
SHD2_k127_6674884_41 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008247 325.0
SHD2_k127_6674884_42 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 311.0
SHD2_k127_6674884_43 Flagellar hook protein FlgE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 311.0
SHD2_k127_6674884_44 Chloramphenicol phosphotransferase-like protein K18554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008696 294.0
SHD2_k127_6674884_45 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 285.0
SHD2_k127_6674884_46 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00410,K00412 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003938 285.0
SHD2_k127_6674884_47 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001222 273.0
SHD2_k127_6674884_48 Protein of unknown function (DUF1013) K09987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000138 268.0
SHD2_k127_6674884_49 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000004551 264.0
SHD2_k127_6674884_5 Aerotolerance regulator N-terminal - - - 1.892e-264 842.0
SHD2_k127_6674884_50 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006429 274.0
SHD2_k127_6674884_51 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000926 258.0
SHD2_k127_6674884_52 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000003402 257.0
SHD2_k127_6674884_53 PFAM Alpha beta hydrolase fold-3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008708 260.0
SHD2_k127_6674884_54 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001804 258.0
SHD2_k127_6674884_55 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000003111 257.0
SHD2_k127_6674884_56 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000001338 244.0
SHD2_k127_6674884_57 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000009563 237.0
SHD2_k127_6674884_58 Protein of unknown function (DUF1285) K09986 - - 0.00000000000000000000000000000000000000000000000000000000000000005859 231.0
SHD2_k127_6674884_59 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008983 234.0
SHD2_k127_6674884_6 membrane - - - 3.697e-228 728.0
SHD2_k127_6674884_60 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000009614 222.0
SHD2_k127_6674884_61 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000002229 214.0
SHD2_k127_6674884_62 DedA family - - - 0.000000000000000000000000000000000000000000000000000000000009131 214.0
SHD2_k127_6674884_63 PFAM Integral membrane protein TerC - - - 0.00000000000000000000000000000000000000000000000000000000006433 211.0
SHD2_k127_6674884_64 Arylesterase - - - 0.0000000000000000000000000000000000000000000000000000000000893 218.0
SHD2_k127_6674884_65 Transcriptional regulatory protein, C terminal K07659 - - 0.0000000000000000000000000000000000000000000000000000000002453 211.0
SHD2_k127_6674884_66 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000003205 201.0
SHD2_k127_6674884_67 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000004615 191.0
SHD2_k127_6674884_68 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000001788 189.0
SHD2_k127_6674884_69 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000001505 186.0
SHD2_k127_6674884_7 Aldehyde dehydrogenase family K00128 - 1.2.1.3 9.315e-220 692.0
SHD2_k127_6674884_70 Belongs to the ParA family K04562 - - 0.000000000000000000000000000000000000000000000003483 183.0
SHD2_k127_6674884_71 chemotaxis protein - - - 0.000000000000000000000000000000000000000000000003599 180.0
SHD2_k127_6674884_72 Macrocin-O-methyltransferase (TylF) - - - 0.0000000000000000000000000000000000000000000000157 192.0
SHD2_k127_6674884_73 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000003142 176.0
SHD2_k127_6674884_74 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000813 172.0
SHD2_k127_6674884_75 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.000000000000000000000000000000000000000000001827 173.0
SHD2_k127_6674884_76 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000008084 169.0
SHD2_k127_6674884_77 Protein of unknown function (DUF1153) - - - 0.0000000000000000000000000000000000000000005297 158.0
SHD2_k127_6674884_78 Protein of unknown function (DUF1465) K13592 - - 0.000000000000000000000000000000000000000003758 160.0
SHD2_k127_6674884_79 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000001196 171.0
SHD2_k127_6674884_8 ABC transporter transmembrane region K06147 - - 5.388e-205 654.0
SHD2_k127_6674884_80 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000197 146.0
SHD2_k127_6674884_81 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005615,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 0.0000000000000000000000000000000000001486 148.0
SHD2_k127_6674884_82 Protein phosphatase 2C - - - 0.000000000000000000000000000000000001618 149.0
SHD2_k127_6674884_83 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000003086 136.0
SHD2_k127_6674884_84 GIY-YIG catalytic domain K07461 - - 0.000000000000000000000000000000005563 131.0
SHD2_k127_6674884_85 oxidoreductase activity - - - 0.000000000000000000000000000000007847 133.0
SHD2_k127_6674884_86 Dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000008802 133.0
SHD2_k127_6674884_87 - - - - 0.00000000000000000000000000000001775 128.0
SHD2_k127_6674884_88 Dihydroneopterin aldolase - - - 0.0000000000000000000000000000000253 134.0
SHD2_k127_6674884_89 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000003397 129.0
SHD2_k127_6674884_9 Sigma-54 interaction domain K10943 - - 6.852e-201 634.0
SHD2_k127_6674884_90 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000003823 126.0
SHD2_k127_6674884_91 Bacterial protein of unknown function (DUF937) - - - 0.00000000000000000000000000001081 122.0
SHD2_k127_6674884_92 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000000001013 121.0
SHD2_k127_6674884_93 Cold shock protein domain K03704 - - 0.0000000000000000000000008736 104.0
SHD2_k127_6674884_94 Belongs to the Nudix hydrolase family - - - 0.00000000000000000000000237 108.0
SHD2_k127_6674884_95 Cold shock K03704 - - 0.00000000000000000000000481 102.0
SHD2_k127_6674884_96 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000001013 105.0
SHD2_k127_6674884_97 Transmembrane sensor domain - - - 0.00000000000000000000001887 115.0
SHD2_k127_6674884_98 Cold shock K03704 - - 0.0000000000000000000001006 99.0
SHD2_k127_6674884_99 - - - - 0.0000000000000000000001678 104.0
SHD2_k127_6964799_0 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 382.0
SHD2_k127_6964799_1 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000882 374.0
SHD2_k127_6964799_10 cheY-homologous receiver domain K13589 - - 0.00000000000000000000000000000000000000000001112 165.0
SHD2_k127_6964799_11 Biopolymer transport protein ExbD/TolR K03559 - - 0.00000000000000000000000000000000000000000007391 163.0
SHD2_k127_6964799_12 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000000000000002949 148.0
SHD2_k127_6964799_13 Autotransporter beta-domain - - - 0.000000000000000000000000000000000000114 165.0
SHD2_k127_6964799_14 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000002539 152.0
SHD2_k127_6964799_15 GtrA-like protein - - - 0.0000000000000000001289 101.0
SHD2_k127_6964799_16 TIGRFAM TonB family protein K03832 - - 0.0000000000000002326 87.0
SHD2_k127_6964799_17 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000001167 64.0
SHD2_k127_6964799_2 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 362.0
SHD2_k127_6964799_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004637 342.0
SHD2_k127_6964799_4 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 333.0
SHD2_k127_6964799_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005524 311.0
SHD2_k127_6964799_6 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 294.0
SHD2_k127_6964799_7 COG4149 ABC-type molybdate transport system, permease component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 288.0
SHD2_k127_6964799_8 Glyoxalase bleomycin resistance protein dioxygenase K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000009323 244.0
SHD2_k127_6964799_9 TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbD K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002102 248.0
SHD2_k127_6988077_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 595.0
SHD2_k127_6988077_1 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 543.0
SHD2_k127_6988077_2 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 450.0
SHD2_k127_6988077_3 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000008258 156.0
SHD2_k127_6988077_4 Regulator - - - 0.0000000000000000000000000000000001297 136.0
SHD2_k127_6988077_5 - - - - 0.000000001372 65.0
SHD2_k127_7080119_0 PD-(D/E)XK nuclease superfamily K16898 - 3.6.4.12 4.216e-272 875.0
SHD2_k127_7080119_1 ATPases associated with a variety of cellular activities K02003,K05685 - - 5.774e-267 841.0
SHD2_k127_7080119_10 chorismate binding enzyme K13950 - 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 546.0
SHD2_k127_7080119_11 amino acid peptide transporter K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 503.0
SHD2_k127_7080119_12 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 477.0
SHD2_k127_7080119_13 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K14980 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 474.0
SHD2_k127_7080119_14 pyridine nucleotide-disulfide oxidoreductase K00529 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 430.0
SHD2_k127_7080119_15 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000777 430.0
SHD2_k127_7080119_16 HlyD family secretion protein K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 411.0
SHD2_k127_7080119_17 ABC transporter, ATP-binding protein K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000421 387.0
SHD2_k127_7080119_18 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 398.0
SHD2_k127_7080119_19 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 380.0
SHD2_k127_7080119_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 3.164e-265 821.0
SHD2_k127_7080119_20 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006618 378.0
SHD2_k127_7080119_21 Transcriptional regulatory protein, C terminal K14981 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 370.0
SHD2_k127_7080119_22 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 370.0
SHD2_k127_7080119_23 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 340.0
SHD2_k127_7080119_24 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 321.0
SHD2_k127_7080119_25 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008651 312.0
SHD2_k127_7080119_26 Phosphotransferase K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 299.0
SHD2_k127_7080119_27 Nucleotidyl transferase K00966,K00992 - 2.7.7.13,2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 291.0
SHD2_k127_7080119_28 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 291.0
SHD2_k127_7080119_29 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000004677 258.0
SHD2_k127_7080119_3 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 2.756e-263 821.0
SHD2_k127_7080119_30 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000001053 252.0
SHD2_k127_7080119_31 TfuA-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000004548 243.0
SHD2_k127_7080119_32 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000000003127 233.0
SHD2_k127_7080119_33 Histidine kinase K11357 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000006097 241.0
SHD2_k127_7080119_34 Cytidylate kinase K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000001349 228.0
SHD2_k127_7080119_35 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000001228 213.0
SHD2_k127_7080119_36 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000000000000001977 201.0
SHD2_k127_7080119_37 Hsp20/alpha crystallin family K04080 - - 0.000000000000000000000000000000000000000000000000002674 185.0
SHD2_k127_7080119_38 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000001055 185.0
SHD2_k127_7080119_39 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000000000000000003974 175.0
SHD2_k127_7080119_4 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 1.193e-238 774.0
SHD2_k127_7080119_40 COG2893 Phosphotransferase system, mannose fructose-specific component IIA K02793 - 2.7.1.191 0.00000000000000000000000000000000000000000000001538 174.0
SHD2_k127_7080119_41 ferredoxin K04755 - - 0.000000000000000000000000000000000000000000001229 166.0
SHD2_k127_7080119_42 Threonylcarbamoyl adenosine biosynthesis protein TsaE K07102 - 2.7.1.221 0.0000000000000000000000000000000000000006874 153.0
SHD2_k127_7080119_43 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.00000000000000000000000000000000000001378 147.0
SHD2_k127_7080119_44 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.00000000000000000000000000000004413 134.0
SHD2_k127_7080119_45 Belongs to the CarB family K01955 - 6.3.5.5 0.00000000000000000000000000003885 117.0
SHD2_k127_7080119_46 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000005579 116.0
SHD2_k127_7080119_47 Serine kinase of the HPr protein, regulates carbohydrate metabolism - - - 0.00000000000000000000000001174 115.0
SHD2_k127_7080119_48 Ankyrin repeat - - - 0.00000000000000000000003458 108.0
SHD2_k127_7080119_49 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.000000000000000000001089 101.0
SHD2_k127_7080119_5 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 3.099e-221 700.0
SHD2_k127_7080119_50 TIGRFAM phosphocarrier, HPr family K11189 - - 0.00000000000000000001563 100.0
SHD2_k127_7080119_51 Protein of unknown function (FYDLN_acid) - - - 0.000000000000001761 85.0
SHD2_k127_7080119_52 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000002581 77.0
SHD2_k127_7080119_53 Protein of unknown function (DUF1150) - - - 0.0000000004917 64.0
SHD2_k127_7080119_54 OstA-like protein K09774 - - 0.0000000006397 68.0
SHD2_k127_7080119_55 Putative heavy-metal-binding - - - 0.0000000114 56.0
SHD2_k127_7080119_56 PAS domain - - - 0.00000001913 63.0
SHD2_k127_7080119_57 - - - - 0.00000003652 55.0
SHD2_k127_7080119_59 smart pdz dhr glgf K04771,K08372 - 3.4.21.107 0.0003497 47.0
SHD2_k127_7080119_6 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 7.455e-203 638.0
SHD2_k127_7080119_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 563.0
SHD2_k127_7080119_8 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 549.0
SHD2_k127_7080119_9 PAS fold - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 560.0
SHD2_k127_7190873_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 9.973e-253 793.0
SHD2_k127_7190873_1 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 3.086e-201 641.0
SHD2_k127_7190873_10 sulfate transport system, permease K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008046 404.0
SHD2_k127_7190873_11 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007421 342.0
SHD2_k127_7190873_12 Citrate synthase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009703 338.0
SHD2_k127_7190873_13 Binding-protein-dependent transport system inner membrane component K02046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 341.0
SHD2_k127_7190873_14 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 317.0
SHD2_k127_7190873_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005788 278.0
SHD2_k127_7190873_16 PFAM Phosphate-selective porin O and P K07221 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000675 271.0
SHD2_k127_7190873_17 araC family K13652,K13653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006143 257.0
SHD2_k127_7190873_18 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000003135 247.0
SHD2_k127_7190873_19 Protein of unknown function (DUF3089) - - - 0.00000000000000000000000000000000000000000000000000000000000003518 228.0
SHD2_k127_7190873_2 sorbosone dehydrogenase - - - 5.965e-199 627.0
SHD2_k127_7190873_20 Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000007696 186.0
SHD2_k127_7190873_21 Protein conserved in bacteria - - - 0.00000000000000000000000000003161 131.0
SHD2_k127_7190873_22 - - - - 0.0000000000002005 78.0
SHD2_k127_7190873_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 567.0
SHD2_k127_7190873_4 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 563.0
SHD2_k127_7190873_5 Methionine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 519.0
SHD2_k127_7190873_6 Bacterial extracellular solute-binding protein K02048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 452.0
SHD2_k127_7190873_7 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 452.0
SHD2_k127_7190873_8 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 454.0
SHD2_k127_7190873_9 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 415.0
SHD2_k127_7234004_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - 0.0 1244.0
SHD2_k127_7234004_1 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0 1056.0
SHD2_k127_7234004_10 Epoxide hydrolase N terminus K01253 - 3.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009923 469.0
SHD2_k127_7234004_11 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008852 432.0
SHD2_k127_7234004_12 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007712 426.0
SHD2_k127_7234004_13 Belongs to the HpcH HpaI aldolase family K08691 - 4.1.3.24,4.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 408.0
SHD2_k127_7234004_14 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 389.0
SHD2_k127_7234004_15 Carbon-nitrogen hydrolase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 346.0
SHD2_k127_7234004_16 Belongs to the 'phage' integrase family. XerC subfamily K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 331.0
SHD2_k127_7234004_17 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 327.0
SHD2_k127_7234004_18 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001221 286.0
SHD2_k127_7234004_19 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005185 287.0
SHD2_k127_7234004_2 helicase superfamily c-terminal domain K17675 - 3.6.4.13 7.684e-270 856.0
SHD2_k127_7234004_20 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005717 253.0
SHD2_k127_7234004_21 transcriptional regulator K07736 - - 0.00000000000000000000000000000000000000000000000000000000000000000001752 237.0
SHD2_k127_7234004_22 PFAM NUDIX hydrolase K03574 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000472 216.0
SHD2_k127_7234004_23 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000000000000000000000000000000000003755 212.0
SHD2_k127_7234004_24 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000000000000000000000000003719 203.0
SHD2_k127_7234004_25 protein conserved in bacteria K15539 - - 0.0000000000000000000000000000000000000000000008615 178.0
SHD2_k127_7234004_26 molecular chaperone - - - 0.00000000000000000000000000000000000000000001342 168.0
SHD2_k127_7234004_27 Protein of unknown function (DUF1178) - - - 0.000000000000000000000000000000000000001099 151.0
SHD2_k127_7234004_28 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000008784 154.0
SHD2_k127_7234004_29 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000251 147.0
SHD2_k127_7234004_3 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 2.7e-247 785.0
SHD2_k127_7234004_30 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000001427 140.0
SHD2_k127_7234004_31 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0033218,GO:0042277,GO:0043167,GO:0043168,GO:0043295,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0055114,GO:0072341,GO:1900750,GO:1901681 - 0.0000000000000000000000000000005428 123.0
SHD2_k127_7234004_32 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000002395 118.0
SHD2_k127_7234004_33 S4 RNA-binding domain K04762 - - 0.00000000000000000000000004454 109.0
SHD2_k127_7234004_34 Belongs to the BolA IbaG family K05527,K22066 - - 0.0000000000000000000000005354 106.0
SHD2_k127_7234004_35 - - - - 0.000000000000000000005167 108.0
SHD2_k127_7234004_36 Staphylococcal nuclease homologue - - - 0.00000000000000000002101 93.0
SHD2_k127_7234004_37 Protein of unknown function (DUF3108) - - - 0.00000000000000000006917 101.0
SHD2_k127_7234004_38 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000004357 91.0
SHD2_k127_7234004_39 - - - - 0.00000000001078 72.0
SHD2_k127_7234004_4 Cobalamin biosynthesis protein CobT VWA domain K09883 - 6.6.1.2 9.155e-239 754.0
SHD2_k127_7234004_41 Flp Fap pilin component K02651 - - 0.0006797 48.0
SHD2_k127_7234004_5 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 571.0
SHD2_k127_7234004_6 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005693 572.0
SHD2_k127_7234004_7 PFAM AAA domain (dynein-related subfamily) K09882 - 6.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 559.0
SHD2_k127_7234004_8 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 503.0
SHD2_k127_7234004_9 Transporter associated domain K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 481.0
SHD2_k127_730769_0 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009258 464.0
SHD2_k127_730769_1 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000001042 111.0
SHD2_k127_7384178_0 Sulfatase K01130 - 3.1.6.1 2.313e-287 885.0
SHD2_k127_7384178_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 369.0
SHD2_k127_7437384_0 Serine carboxypeptidase - - - 8.939e-219 691.0
SHD2_k127_7437384_1 cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008695 584.0
SHD2_k127_7437384_10 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000286 203.0
SHD2_k127_7437384_11 DoxX - - - 0.0000000000000000000000000000000000000000000000000000002315 199.0
SHD2_k127_7437384_12 - - - - 0.0000000000000000000000000000000000000000000000000000008568 210.0
SHD2_k127_7437384_13 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000214 192.0
SHD2_k127_7437384_14 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000001272 175.0
SHD2_k127_7437384_15 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000000000000000000000004576 180.0
SHD2_k127_7437384_16 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000003918 171.0
SHD2_k127_7437384_17 acetyltransferase - - - 0.000000000000000000000000000000000000000006138 160.0
SHD2_k127_7437384_18 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000008459 165.0
SHD2_k127_7437384_19 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000002167 151.0
SHD2_k127_7437384_2 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 574.0
SHD2_k127_7437384_20 PAS domain - - - 0.0000000000000000000000000000000005669 138.0
SHD2_k127_7437384_21 - - - - 0.00000000000000000000000000000001358 135.0
SHD2_k127_7437384_22 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000002434 130.0
SHD2_k127_7437384_23 - - - - 0.0000000000000000000000000000001549 127.0
SHD2_k127_7437384_24 Haem-binding domain - - - 0.000000000000000000000000422 113.0
SHD2_k127_7437384_25 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000009293 102.0
SHD2_k127_7437384_27 PAS domain - - - 0.000000000005092 72.0
SHD2_k127_7437384_28 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000008733 70.0
SHD2_k127_7437384_29 PFAM Flp Fap pilin component K02651 - - 0.0000000002477 63.0
SHD2_k127_7437384_3 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 452.0
SHD2_k127_7437384_30 CAAX protease self-immunity K07052 - - 0.000000001488 67.0
SHD2_k127_7437384_31 - - - - 0.000000004959 64.0
SHD2_k127_7437384_32 CAAX protease self-immunity K07052 - - 0.000007858 57.0
SHD2_k127_7437384_33 - - - - 0.00001436 49.0
SHD2_k127_7437384_34 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.00008467 50.0
SHD2_k127_7437384_36 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.0004568 49.0
SHD2_k127_7437384_37 peptidase - - - 0.0009183 48.0
SHD2_k127_7437384_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 396.0
SHD2_k127_7437384_5 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 363.0
SHD2_k127_7437384_6 Sulfite exporter TauE/SafE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 335.0
SHD2_k127_7437384_7 low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 296.0
SHD2_k127_7437384_8 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009419 255.0
SHD2_k127_7437384_9 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005797 246.0
SHD2_k127_7468224_0 Belongs to the heme-copper respiratory oxidase family K02298 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.10.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 573.0
SHD2_k127_7468224_1 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 529.0
SHD2_k127_7468224_2 ubiquinol oxidase subunit K02297 - 1.10.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 379.0
SHD2_k127_7468224_3 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 329.0
SHD2_k127_7468224_4 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000001689 184.0
SHD2_k127_7468224_5 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.000000000000000000000000000000000000325 150.0
SHD2_k127_7468224_6 Belongs to the 'phage' integrase family - - - 0.000000000000000000001534 97.0
SHD2_k127_7558494_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 5e-324 1006.0
SHD2_k127_7558494_1 Proton-conducting membrane transporter - - - 5.028e-287 895.0
SHD2_k127_7558494_10 Delta-aminolevulinic acid dehydratase K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 501.0
SHD2_k127_7558494_11 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 454.0
SHD2_k127_7558494_12 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 451.0
SHD2_k127_7558494_13 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 428.0
SHD2_k127_7558494_14 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 411.0
SHD2_k127_7558494_15 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 374.0
SHD2_k127_7558494_16 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 354.0
SHD2_k127_7558494_17 COG4237 Hydrogenase 4 membrane component (E) K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006669 338.0
SHD2_k127_7558494_18 HlyD family secretion protein K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 334.0
SHD2_k127_7558494_19 chemotaxis MotB protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 321.0
SHD2_k127_7558494_2 Proton-conducting membrane transporter K12141 - - 2.428e-244 764.0
SHD2_k127_7558494_20 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 310.0
SHD2_k127_7558494_21 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 295.0
SHD2_k127_7558494_22 Riboflavin synthase alpha chain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 282.0
SHD2_k127_7558494_23 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007699 260.0
SHD2_k127_7558494_24 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000000000000000005847 233.0
SHD2_k127_7558494_25 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000008674 238.0
SHD2_k127_7558494_26 PFAM Phosphate-selective porin O and P K07221 - - 0.0000000000000000000000000000000000000000000000000000000000000000008558 249.0
SHD2_k127_7558494_27 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000000000000000001214 211.0
SHD2_k127_7558494_28 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000001379 196.0
SHD2_k127_7558494_29 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000003322 183.0
SHD2_k127_7558494_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.014e-231 730.0
SHD2_k127_7558494_30 ROS/MUCR transcriptional regulator protein - - - 0.0000000000000000000000000000000000000000000000007842 178.0
SHD2_k127_7558494_31 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000002114 177.0
SHD2_k127_7558494_32 MerR HTH family regulatory protein - - - 0.000000000000000000000000000000000000002143 153.0
SHD2_k127_7558494_33 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000000000002591 153.0
SHD2_k127_7558494_34 Protein of unknown function (DUF1345) - - - 0.000000000000000000000000000000000000005113 154.0
SHD2_k127_7558494_35 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000001081 143.0
SHD2_k127_7558494_36 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000003613 142.0
SHD2_k127_7558494_37 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000252 139.0
SHD2_k127_7558494_38 COG2913 Small protein A (tmRNA-binding) - - - 0.0000000000000000000000000000000007151 136.0
SHD2_k127_7558494_39 WHG domain - - - 0.0000000000000000000000000000001981 130.0
SHD2_k127_7558494_4 NADH-ubiquinone oxidoreductase chain 49kDa - - - 5.581e-227 712.0
SHD2_k127_7558494_40 transcriptional regulator - - - 0.0000000000000000000000000007829 118.0
SHD2_k127_7558494_41 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.00000000000000000000000001242 113.0
SHD2_k127_7558494_42 Ubiquinol-cytochrome C chaperone K17662 - - 0.00000000000000000000000002385 115.0
SHD2_k127_7558494_43 FR47-like protein - - - 0.000000000000000000000003423 109.0
SHD2_k127_7558494_44 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000004082 104.0
SHD2_k127_7558494_45 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000007184 96.0
SHD2_k127_7558494_46 Helix-turn-helix XRE-family like proteins - - - 0.0000000007151 59.0
SHD2_k127_7558494_47 - - - - 0.000000004342 63.0
SHD2_k127_7558494_48 - - - - 0.000001289 53.0
SHD2_k127_7558494_5 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 3.107e-210 660.0
SHD2_k127_7558494_6 Sugar (and other) transporter K03446 - - 1.68e-198 632.0
SHD2_k127_7558494_7 Cys/Met metabolism PLP-dependent enzyme K00643 - 2.3.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 582.0
SHD2_k127_7558494_8 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 576.0
SHD2_k127_7558494_9 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858,K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 520.0
SHD2_k127_7560602_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 2524.0
SHD2_k127_7560602_1 Threonyl and Alanyl tRNA synthetase second additional domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0 1151.0
SHD2_k127_7560602_10 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 2.471e-241 749.0
SHD2_k127_7560602_100 Transporter associated domain K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 291.0
SHD2_k127_7560602_101 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008614 282.0
SHD2_k127_7560602_102 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000105 289.0
SHD2_k127_7560602_103 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001218 284.0
SHD2_k127_7560602_104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003295 275.0
SHD2_k127_7560602_105 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009379 284.0
SHD2_k127_7560602_106 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001505 282.0
SHD2_k127_7560602_107 Transmembrane protein 43 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002484 283.0
SHD2_k127_7560602_108 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001546 270.0
SHD2_k127_7560602_109 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000001218 273.0
SHD2_k127_7560602_11 Acyl-CoA dehydrogenase, C-terminal domain K14448 - 1.3.8.12 1.508e-232 731.0
SHD2_k127_7560602_110 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000002018 265.0
SHD2_k127_7560602_111 PFAM Scaffold protein Nfu NifU N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002882 263.0
SHD2_k127_7560602_112 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000003215 264.0
SHD2_k127_7560602_113 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000005082 265.0
SHD2_k127_7560602_114 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002361 258.0
SHD2_k127_7560602_115 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000007081 258.0
SHD2_k127_7560602_116 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001844 269.0
SHD2_k127_7560602_117 Phospholipase/Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003175 257.0
SHD2_k127_7560602_118 NnrU protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000181 254.0
SHD2_k127_7560602_119 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000002371 255.0
SHD2_k127_7560602_12 Belongs to the peptidase M16 family K07263 - - 5.128e-227 736.0
SHD2_k127_7560602_120 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005286 259.0
SHD2_k127_7560602_121 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008519 252.0
SHD2_k127_7560602_122 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004354 251.0
SHD2_k127_7560602_123 Belongs to the MIP aquaporin (TC 1.A.8) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005413 243.0
SHD2_k127_7560602_124 Protein conserved in bacteria K09798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000539 247.0
SHD2_k127_7560602_125 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000001455 237.0
SHD2_k127_7560602_126 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000000000000000002285 233.0
SHD2_k127_7560602_127 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000001011 231.0
SHD2_k127_7560602_128 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.000000000000000000000000000000000000000000000000000000000000000003716 234.0
SHD2_k127_7560602_129 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000001027 251.0
SHD2_k127_7560602_13 PQQ-like domain K00117 - 1.1.5.2 1.113e-218 697.0
SHD2_k127_7560602_130 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000001231 230.0
SHD2_k127_7560602_131 Bacterial export proteins, family 1 K02421 - - 0.0000000000000000000000000000000000000000000000000000000000000009761 227.0
SHD2_k127_7560602_132 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000000000000000000000000000000000000000000178 218.0
SHD2_k127_7560602_133 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000142 223.0
SHD2_k127_7560602_134 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000000333 215.0
SHD2_k127_7560602_135 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000002502 217.0
SHD2_k127_7560602_136 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000000000000000000000000002889 215.0
SHD2_k127_7560602_137 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000005491 213.0
SHD2_k127_7560602_138 Fatty acid desaturase - - - 0.00000000000000000000000000000000000000000000000000000000003569 220.0
SHD2_k127_7560602_139 Belongs to the flagella basal body rod proteins family K02391,K02392 - - 0.0000000000000000000000000000000000000000000000000000000000696 215.0
SHD2_k127_7560602_14 Bacterial protein of unknown function (DUF885) - - - 1.434e-209 672.0
SHD2_k127_7560602_140 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000009565 213.0
SHD2_k127_7560602_141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06991 - - 0.000000000000000000000000000000000000000000000000000000000364 207.0
SHD2_k127_7560602_142 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000001009 204.0
SHD2_k127_7560602_143 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K16168 - - 0.0000000000000000000000000000000000000000000000000000001449 202.0
SHD2_k127_7560602_144 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000002828 198.0
SHD2_k127_7560602_145 Flagellar basal body rod FlgEFG protein C-terminal K02388 - - 0.00000000000000000000000000000000000000000000000003041 181.0
SHD2_k127_7560602_146 COG1668 ABC-type Na efflux pump, permease component K01992 - - 0.0000000000000000000000000000000000000000000000007907 196.0
SHD2_k127_7560602_148 Flagellar protein FlbT K06601 - - 0.0000000000000000000000000000000000000000000000009812 178.0
SHD2_k127_7560602_149 transmembrane signaling receptor activity - - - 0.000000000000000000000000000000000000000000000004837 195.0
SHD2_k127_7560602_15 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 4.168e-208 654.0
SHD2_k127_7560602_150 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000003108 176.0
SHD2_k127_7560602_151 COQ9 K18587 - - 0.0000000000000000000000000000000000000000000005448 174.0
SHD2_k127_7560602_152 Autoinducer synthase K18096 - 2.3.1.228,2.3.1.229 0.000000000000000000000000000000000000000000002413 171.0
SHD2_k127_7560602_153 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000000005492 171.0
SHD2_k127_7560602_154 - - - - 0.000000000000000000000000000000000000000000006442 171.0
SHD2_k127_7560602_155 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000001815 164.0
SHD2_k127_7560602_156 Flavin containing amine oxidoreductase K06954 - - 0.00000000000000000000000000000000000000000002803 166.0
SHD2_k127_7560602_157 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000004473 163.0
SHD2_k127_7560602_158 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000006012 167.0
SHD2_k127_7560602_159 PFAM Cupin 2 conserved barrel domain protein K05913 - 1.13.11.41 0.0000000000000000000000000000000000000000001433 163.0
SHD2_k127_7560602_16 VWA domain containing CoxE-like protein K09989 - - 4.911e-203 640.0
SHD2_k127_7560602_160 - - - - 0.000000000000000000000000000000000000000000287 164.0
SHD2_k127_7560602_161 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000003581 161.0
SHD2_k127_7560602_162 methyltransferase - - - 0.0000000000000000000000000000000000000001256 158.0
SHD2_k127_7560602_163 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.0000000000000000000000000000000000000001326 169.0
SHD2_k127_7560602_164 Domain of unknown function (DUF3576) - - - 0.000000000000000000000000000000000000000512 153.0
SHD2_k127_7560602_165 COG2771 DNA-binding HTH domain-containing proteins - - - 0.0000000000000000000000000000000000000009563 158.0
SHD2_k127_7560602_166 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000158 150.0
SHD2_k127_7560602_167 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000000000000000001632 149.0
SHD2_k127_7560602_168 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000004554 147.0
SHD2_k127_7560602_169 PFAM peptidase M22 glycoprotease K14742 - - 0.00000000000000000000000000000000000004709 150.0
SHD2_k127_7560602_17 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 2.602e-197 628.0
SHD2_k127_7560602_170 Domain of unknown function (DUF4260) - - - 0.00000000000000000000000000000000000009324 146.0
SHD2_k127_7560602_171 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000002722 148.0
SHD2_k127_7560602_172 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000002959 138.0
SHD2_k127_7560602_173 Peptidase family M23 - - - 0.0000000000000000000000000000000001055 149.0
SHD2_k127_7560602_174 PFAM CHAD domain containing protein - - - 0.000000000000000000000000000000001145 142.0
SHD2_k127_7560602_175 FR47-like protein - - - 0.00000000000000000000000000000000523 138.0
SHD2_k127_7560602_176 transcriptional regulators K03892 - - 0.00000000000000000000000000000001001 130.0
SHD2_k127_7560602_177 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.00000000000000000000000000000001808 134.0
SHD2_k127_7560602_178 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000003428 130.0
SHD2_k127_7560602_179 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000003722 130.0
SHD2_k127_7560602_18 Acyl-CoA dehydrogenase, N-terminal domain - - - 1.668e-196 619.0
SHD2_k127_7560602_180 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000000002268 128.0
SHD2_k127_7560602_181 Disulfide bond formation protein - - - 0.0000000000000000000000000000002968 130.0
SHD2_k127_7560602_182 Cytochrome c-type biogenesis protein K02200 - - 0.0000000000000000000000000000004787 135.0
SHD2_k127_7560602_183 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000003877 122.0
SHD2_k127_7560602_184 Domain of unknown function (DUF1476) - - - 0.000000000000000000000000000006384 121.0
SHD2_k127_7560602_185 PFAM MgtE intracellular - - - 0.0000000000000000000000000001804 130.0
SHD2_k127_7560602_186 - - - - 0.0000000000000000000000000002346 119.0
SHD2_k127_7560602_187 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000007977 115.0
SHD2_k127_7560602_188 Flagellar protein FlaF K06602 - - 0.0000000000000000000000000008767 115.0
SHD2_k127_7560602_189 Belongs to the BolA IbaG family - - - 0.0000000000000000000000000446 108.0
SHD2_k127_7560602_19 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 5.374e-196 620.0
SHD2_k127_7560602_190 Cupin domain - - - 0.00000000000000000000000004901 114.0
SHD2_k127_7560602_191 PQ loop repeat K15383 - - 0.0000000000000000000000000702 109.0
SHD2_k127_7560602_192 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.0000000000000000000000001427 112.0
SHD2_k127_7560602_193 Thiamine monophosphate synthase - - - 0.000000000000000000000002891 109.0
SHD2_k127_7560602_194 COG0582 Integrase K04763 - - 0.000000000000000000000007932 107.0
SHD2_k127_7560602_195 FR47-like protein - - - 0.00000000000000000000001712 112.0
SHD2_k127_7560602_196 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000000000000000131 102.0
SHD2_k127_7560602_197 Rod binding protein - - - 0.0000000000000000000003783 101.0
SHD2_k127_7560602_198 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.000000000000000000001388 106.0
SHD2_k127_7560602_199 lactoylglutathione lyase activity - - - 0.000000000000000000003394 100.0
SHD2_k127_7560602_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1107.0
SHD2_k127_7560602_20 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 593.0
SHD2_k127_7560602_200 Acetyltransferase (GNAT) domain - - - 0.000000000000000000009735 98.0
SHD2_k127_7560602_201 Flagellar biosynthesis K02420 - - 0.00000000000000000004174 92.0
SHD2_k127_7560602_202 - - - - 0.0000000000000000001667 99.0
SHD2_k127_7560602_203 - - - - 0.0000000000000000003791 90.0
SHD2_k127_7560602_204 Cupredoxin-like domain - - - 0.000000000000000001117 90.0
SHD2_k127_7560602_205 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000114 94.0
SHD2_k127_7560602_206 Gram-negative porin K08720 - - 0.000000000000000435 91.0
SHD2_k127_7560602_207 - - - - 0.000000000000004009 84.0
SHD2_k127_7560602_208 Lipopolysaccharide-assembly K03643 - - 0.000000000000007529 82.0
SHD2_k127_7560602_209 Flagellar biosynthesis protein, FliO - - - 0.000000000000009035 78.0
SHD2_k127_7560602_21 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000943 595.0
SHD2_k127_7560602_210 Protein of unknown function (DUF465) - - - 0.00000000000001023 79.0
SHD2_k127_7560602_211 transcriptional regulator - - - 0.00000000000001141 83.0
SHD2_k127_7560602_212 Protein involved in outer membrane biogenesis - - - 0.0000000000004858 81.0
SHD2_k127_7560602_213 Flagellar hook-basal body K02408 - - 0.0000000000005289 72.0
SHD2_k127_7560602_214 Histidine kinase K07647 - 2.7.13.3 0.000000000002113 72.0
SHD2_k127_7560602_215 Protein of unknown function (DUF1674) - - - 0.00000000001051 67.0
SHD2_k127_7560602_216 SAF K02386 - - 0.00000000001595 72.0
SHD2_k127_7560602_218 small protein - - - 0.0000000405 56.0
SHD2_k127_7560602_22 Belongs to the thiolase family K07823 - 2.3.1.174 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 585.0
SHD2_k127_7560602_220 - - - - 0.0000001458 63.0
SHD2_k127_7560602_221 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000001491 63.0
SHD2_k127_7560602_223 - - - - 0.0000009893 57.0
SHD2_k127_7560602_224 Sulfotransferase domain - - - 0.0000009986 60.0
SHD2_k127_7560602_225 OpgC protein - - - 0.000001989 50.0
SHD2_k127_7560602_226 Bacterial protein of unknown function (DUF883) - - - 0.0000105 52.0
SHD2_k127_7560602_227 Belongs to the ABC transporter superfamily K13896 - - 0.00001102 49.0
SHD2_k127_7560602_228 OpgC protein - - - 0.0001109 46.0
SHD2_k127_7560602_229 OpgC protein - - - 0.0001944 45.0
SHD2_k127_7560602_23 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002593 569.0
SHD2_k127_7560602_230 Chagasin family peptidase inhibitor I42 K14475 - - 0.0003197 48.0
SHD2_k127_7560602_231 - - - - 0.0003226 51.0
SHD2_k127_7560602_232 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0009439 51.0
SHD2_k127_7560602_24 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 569.0
SHD2_k127_7560602_25 Major facilitator Superfamily K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 569.0
SHD2_k127_7560602_26 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 574.0
SHD2_k127_7560602_27 Glycosyl hydrolase family 57 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008905 569.0
SHD2_k127_7560602_28 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 552.0
SHD2_k127_7560602_29 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005095 551.0
SHD2_k127_7560602_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1020.0
SHD2_k127_7560602_30 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 543.0
SHD2_k127_7560602_31 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 526.0
SHD2_k127_7560602_32 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007152 523.0
SHD2_k127_7560602_33 isovaleryl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 508.0
SHD2_k127_7560602_34 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 508.0
SHD2_k127_7560602_35 His Kinase A (phosphoacceptor) domain K13587 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 517.0
SHD2_k127_7560602_36 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 492.0
SHD2_k127_7560602_37 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 509.0
SHD2_k127_7560602_38 ferredoxin--NADP reductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 492.0
SHD2_k127_7560602_39 Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 486.0
SHD2_k127_7560602_4 Anion-transporting ATPase K01551 - 3.6.3.16 1.768e-302 936.0
SHD2_k127_7560602_40 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 483.0
SHD2_k127_7560602_41 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 509.0
SHD2_k127_7560602_42 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 473.0
SHD2_k127_7560602_43 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 467.0
SHD2_k127_7560602_44 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003785 458.0
SHD2_k127_7560602_45 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 454.0
SHD2_k127_7560602_46 Major facilitator Superfamily K08151 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009568 439.0
SHD2_k127_7560602_47 Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase K07257 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 445.0
SHD2_k127_7560602_48 GtrA-like protein K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 430.0
SHD2_k127_7560602_49 Chalcone and stilbene synthases, C-terminal domain K16167 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 423.0
SHD2_k127_7560602_5 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 2.848e-299 934.0
SHD2_k127_7560602_50 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 419.0
SHD2_k127_7560602_51 nitrite reductase [NAD(P)H] activity K15762 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006906 432.0
SHD2_k127_7560602_52 Methionine aminopeptidase K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 417.0
SHD2_k127_7560602_53 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 417.0
SHD2_k127_7560602_54 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 416.0
SHD2_k127_7560602_55 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 417.0
SHD2_k127_7560602_56 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 404.0
SHD2_k127_7560602_57 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 411.0
SHD2_k127_7560602_58 TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 415.0
SHD2_k127_7560602_59 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006125 393.0
SHD2_k127_7560602_6 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 3.772e-279 871.0
SHD2_k127_7560602_60 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 398.0
SHD2_k127_7560602_61 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 398.0
SHD2_k127_7560602_62 acid synthase K01654 - 2.5.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 385.0
SHD2_k127_7560602_63 synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 389.0
SHD2_k127_7560602_64 Phytanoyl-CoA dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 377.0
SHD2_k127_7560602_65 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009192 374.0
SHD2_k127_7560602_66 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009451 373.0
SHD2_k127_7560602_67 PFAM Protein-tyrosine phosphatase, low molecular weight K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 364.0
SHD2_k127_7560602_68 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000076 365.0
SHD2_k127_7560602_69 COG1702 Phosphate starvation-inducible protein PhoH K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 352.0
SHD2_k127_7560602_7 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 4.258e-267 829.0
SHD2_k127_7560602_70 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 351.0
SHD2_k127_7560602_71 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 360.0
SHD2_k127_7560602_72 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 354.0
SHD2_k127_7560602_73 Catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide K03119 GO:0000907,GO:0000908,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0051213,GO:0055114 1.14.11.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005997 342.0
SHD2_k127_7560602_74 COG0708 Exonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008799 338.0
SHD2_k127_7560602_75 Flagellar basal body rod FlgEFG protein C-terminal K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 333.0
SHD2_k127_7560602_76 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 333.0
SHD2_k127_7560602_77 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000592 337.0
SHD2_k127_7560602_78 Transketolase central region K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000545 334.0
SHD2_k127_7560602_79 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008439 320.0
SHD2_k127_7560602_8 peptidase K07386 - - 4.886e-267 839.0
SHD2_k127_7560602_80 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007209 319.0
SHD2_k127_7560602_81 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008136 330.0
SHD2_k127_7560602_82 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 318.0
SHD2_k127_7560602_83 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009975 314.0
SHD2_k127_7560602_84 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000572 323.0
SHD2_k127_7560602_85 PFAM Methyltransferase type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 318.0
SHD2_k127_7560602_86 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008629 312.0
SHD2_k127_7560602_87 Cation efflux family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 316.0
SHD2_k127_7560602_88 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008163 306.0
SHD2_k127_7560602_89 abc transporter atp-binding protein K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 307.0
SHD2_k127_7560602_9 reductase K00001,K14446 - 1.1.1.1,1.3.1.85 5.703e-248 769.0
SHD2_k127_7560602_90 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 302.0
SHD2_k127_7560602_91 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 306.0
SHD2_k127_7560602_92 Ion channel K10716 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 312.0
SHD2_k127_7560602_93 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 297.0
SHD2_k127_7560602_94 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 294.0
SHD2_k127_7560602_95 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 300.0
SHD2_k127_7560602_96 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 292.0
SHD2_k127_7560602_97 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 292.0
SHD2_k127_7560602_98 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 289.0
SHD2_k127_7560602_99 PFAM Transketolase K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 291.0
SHD2_k127_7589968_0 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 414.0
SHD2_k127_7589968_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004048 255.0
SHD2_k127_7589968_2 Psort location Extracellular, score - - - 0.0000000000000000000000000000000001222 139.0
SHD2_k127_7589968_3 Adenylate cyclase - - - 0.0000000000001769 76.0
SHD2_k127_7600676_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1143.0
SHD2_k127_7600676_1 4-coumarate--CoA - - - 3.769e-214 676.0
SHD2_k127_7600676_11 WHG domain - - - 0.0003189 51.0
SHD2_k127_7600676_2 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 420.0
SHD2_k127_7600676_3 Thioesterase K07107 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005169 274.0
SHD2_k127_7600676_4 DJ-1/PfpI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005261 251.0
SHD2_k127_7600676_5 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.00000000000000000000000000000000000000000000000000000000000000000592 233.0
SHD2_k127_7600676_6 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000003497 233.0
SHD2_k127_7600676_7 PFAM MaoC domain protein dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000005999 219.0
SHD2_k127_7600676_8 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000634 203.0
SHD2_k127_7600676_9 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000000003547 120.0
SHD2_k127_7724507_0 Transposase DDE domain group 1 - - - 1.693e-198 620.0
SHD2_k127_7724507_1 PFAM Integrase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003913 509.0
SHD2_k127_7724507_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008728 383.0
SHD2_k127_7724507_3 Transposase - - - 0.0000000000000000000000000000000000000000002126 160.0
SHD2_k127_7724507_4 PilZ domain - - - 0.000000001774 59.0
SHD2_k127_7724507_5 - - - - 0.00000002613 56.0
SHD2_k127_7724507_6 Flp/Fap pilin component K02651 - - 0.000004367 48.0
SHD2_k127_7739950_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 444.0
SHD2_k127_7739950_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000001625 193.0
SHD2_k127_7739950_2 - - - - 0.00000000000000000000005676 98.0
SHD2_k127_7739950_3 transcriptional regulator - - - 0.00000001305 58.0
SHD2_k127_7739950_4 - - - - 0.00002812 46.0
SHD2_k127_7782023_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 5.216e-238 747.0
SHD2_k127_7782023_1 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 4.951e-228 715.0
SHD2_k127_7782023_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 522.0
SHD2_k127_7782023_3 NADP-dependent oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 448.0
SHD2_k127_7782023_4 Bacterial transcription activator, effector binding domain K13652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 304.0
SHD2_k127_7782023_5 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000104 213.0
SHD2_k127_7782023_6 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000434 152.0
SHD2_k127_7782023_7 - - - - 0.00000001734 63.0
SHD2_k127_77935_0 hmm pf01609 K07481 - - 3.506e-238 741.0
SHD2_k127_7807355_0 Rieske 2Fe-2S - - - 1.289e-214 677.0
SHD2_k127_7807355_1 Acyl-CoA dehydrogenase, middle domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 595.0
SHD2_k127_7807355_10 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000002459 185.0
SHD2_k127_7807355_11 SnoaL-like domain - - - 0.00000000000000000000000000000000003834 138.0
SHD2_k127_7807355_12 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000001142 121.0
SHD2_k127_7807355_13 Limonene-1,2-epoxide hydrolase catalytic domain - - - 0.000000000000000000000000005975 117.0
SHD2_k127_7807355_2 cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 589.0
SHD2_k127_7807355_3 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 442.0
SHD2_k127_7807355_4 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 420.0
SHD2_k127_7807355_5 Protein conserved in bacteria K09992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 407.0
SHD2_k127_7807355_6 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 386.0
SHD2_k127_7807355_7 short-chain dehydrogenase K05296 - 1.1.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 347.0
SHD2_k127_7807355_8 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006175 269.0
SHD2_k127_7807355_9 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000002324 207.0
SHD2_k127_7862734_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 549.0
SHD2_k127_7862734_1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002137 271.0
SHD2_k127_7862734_2 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000001639 192.0
SHD2_k127_7917077_0 C-terminal, D2-small domain, of ClpB protein K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.0 1189.0
SHD2_k127_7917077_1 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1159.0
SHD2_k127_7917077_10 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002906 291.0
SHD2_k127_7917077_11 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000001809 230.0
SHD2_k127_7917077_12 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000000001932 190.0
SHD2_k127_7917077_13 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000000000001045 179.0
SHD2_k127_7917077_14 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.000000000000000000000000000000000000000000000003467 175.0
SHD2_k127_7917077_15 translation initiation inhibitor, yjgF family - - - 0.0000000000000000000000000000000000000000000003406 177.0
SHD2_k127_7917077_16 UMP catabolic process - - - 0.0000000000000000000000000000000000000000000004446 173.0
SHD2_k127_7917077_17 - - - - 0.0000000000000000000000000000000000000000000008123 169.0
SHD2_k127_7917077_18 Protein of unknown function (DUF1489) - - - 0.000000000000000000000000000000000000000000008762 167.0
SHD2_k127_7917077_19 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000003389 151.0
SHD2_k127_7917077_2 Carboxyl transferase domain K01969 - 6.4.1.4 4.564e-232 725.0
SHD2_k127_7917077_20 RNHCP domain - - - 0.000000000000000000000000000001644 125.0
SHD2_k127_7917077_21 Endonuclease containing a URI domain K07461 - - 0.00000000000000000000004045 106.0
SHD2_k127_7917077_22 Phasin protein - - - 0.000000000000007223 80.0
SHD2_k127_7917077_3 carboxylase K01965,K01968 - 6.4.1.3,6.4.1.4 1.494e-227 722.0
SHD2_k127_7917077_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 503.0
SHD2_k127_7917077_5 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 474.0
SHD2_k127_7917077_6 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 431.0
SHD2_k127_7917077_7 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008012 368.0
SHD2_k127_7917077_8 ROK family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 349.0
SHD2_k127_7917077_9 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 309.0
SHD2_k127_7944610_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1489.0
SHD2_k127_7944610_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1172.0
SHD2_k127_7944610_10 TonB dependent receptor - - - 5.931e-228 728.0
SHD2_k127_7944610_100 Protein of unknown function (DUF2794) - - - 0.0000000000000000000000000000000000003739 145.0
SHD2_k127_7944610_101 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000001019 143.0
SHD2_k127_7944610_102 invasion associated locus B - - - 0.00000000000000000000000000000003567 132.0
SHD2_k127_7944610_103 RNA polymerase Rpb6 K03060 - 2.7.7.6 0.0000000000000000000000000000004601 126.0
SHD2_k127_7944610_104 glyoxalase III activity - - - 0.0000000000000000000000000000009947 129.0
SHD2_k127_7944610_105 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000002201 124.0
SHD2_k127_7944610_106 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000004183 124.0
SHD2_k127_7944610_107 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000002587 119.0
SHD2_k127_7944610_108 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.00000000000000000000000002361 111.0
SHD2_k127_7944610_109 Transglycosylase associated protein - - - 0.00000000000000000000007424 100.0
SHD2_k127_7944610_11 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 1.707e-227 714.0
SHD2_k127_7944610_110 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000008889 100.0
SHD2_k127_7944610_111 MerR, DNA binding K13639 - - 0.0000000000000000000003996 103.0
SHD2_k127_7944610_112 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000003371 92.0
SHD2_k127_7944610_113 Domain of unknown function (DUF4340) - - - 0.00000000000000000001199 105.0
SHD2_k127_7944610_114 Belongs to the bacterial ribosomal protein bL33 family K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000002752 92.0
SHD2_k127_7944610_115 protein conserved in bacteria K09984 - - 0.00000000000000000008614 91.0
SHD2_k127_7944610_118 Flp Fap pilin component K02651 - - 0.00000000002726 66.0
SHD2_k127_7944610_119 - - - - 0.00000000004211 70.0
SHD2_k127_7944610_12 argininosuccinate synthase activity K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 1.733e-226 705.0
SHD2_k127_7944610_120 Evidence 5 No homology to any previously reported sequences - - - 0.000000000414 61.0
SHD2_k127_7944610_121 nucleotidyltransferase activity - - - 0.000000001424 70.0
SHD2_k127_7944610_122 - - - - 0.000000001652 62.0
SHD2_k127_7944610_124 Protein of unknown function (DUF1453) - - - 0.00002547 53.0
SHD2_k127_7944610_125 - - - - 0.00002632 53.0
SHD2_k127_7944610_126 PilZ domain - - - 0.00005007 50.0
SHD2_k127_7944610_128 COG3631 Ketosteroid isomerase-related protein K06893 - - 0.00007684 52.0
SHD2_k127_7944610_13 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.275e-222 705.0
SHD2_k127_7944610_14 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 1.757e-213 673.0
SHD2_k127_7944610_15 acyl-CoA dehydrogenase - - - 1.844e-212 666.0
SHD2_k127_7944610_16 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 580.0
SHD2_k127_7944610_17 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038,K21977 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008712 566.0
SHD2_k127_7944610_18 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 536.0
SHD2_k127_7944610_19 ABC-type uncharacterized transport system K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009678 544.0
SHD2_k127_7944610_2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1091.0
SHD2_k127_7944610_20 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 520.0
SHD2_k127_7944610_21 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006439 519.0
SHD2_k127_7944610_22 Cysteine synthase K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 499.0
SHD2_k127_7944610_23 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 499.0
SHD2_k127_7944610_24 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 464.0
SHD2_k127_7944610_25 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 458.0
SHD2_k127_7944610_26 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 434.0
SHD2_k127_7944610_27 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007682 420.0
SHD2_k127_7944610_28 Transglycosylase SLT domain K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 434.0
SHD2_k127_7944610_29 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 411.0
SHD2_k127_7944610_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1075.0
SHD2_k127_7944610_30 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 403.0
SHD2_k127_7944610_31 major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008088 404.0
SHD2_k127_7944610_32 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004228 391.0
SHD2_k127_7944610_33 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008111 389.0
SHD2_k127_7944610_34 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 384.0
SHD2_k127_7944610_35 major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004907 388.0
SHD2_k127_7944610_36 PFAM Enoyl-CoA hydratase isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 370.0
SHD2_k127_7944610_37 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007518 372.0
SHD2_k127_7944610_38 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 362.0
SHD2_k127_7944610_39 Creatininase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 355.0
SHD2_k127_7944610_4 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 4.108e-302 943.0
SHD2_k127_7944610_40 ABC transporter permease K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 348.0
SHD2_k127_7944610_41 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008064 357.0
SHD2_k127_7944610_42 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008321 350.0
SHD2_k127_7944610_43 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 355.0
SHD2_k127_7944610_44 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 340.0
SHD2_k127_7944610_45 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 331.0
SHD2_k127_7944610_46 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 325.0
SHD2_k127_7944610_47 Oxidoreductase molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 318.0
SHD2_k127_7944610_48 Thioesterase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 317.0
SHD2_k127_7944610_49 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 317.0
SHD2_k127_7944610_5 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 3.981e-298 923.0
SHD2_k127_7944610_50 alpha/beta hydrolase fold K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006219 319.0
SHD2_k127_7944610_51 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 318.0
SHD2_k127_7944610_52 MFS_1 like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 315.0
SHD2_k127_7944610_53 alpha/beta hydrolase fold K01066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 308.0
SHD2_k127_7944610_54 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 304.0
SHD2_k127_7944610_55 ABC transporter K02003 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 297.0
SHD2_k127_7944610_56 Belongs to the BI1 family K06890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007686 296.0
SHD2_k127_7944610_57 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 297.0
SHD2_k127_7944610_58 NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004376 291.0
SHD2_k127_7944610_59 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009334 284.0
SHD2_k127_7944610_6 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 8.436e-257 813.0
SHD2_k127_7944610_60 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002135 278.0
SHD2_k127_7944610_61 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007982 278.0
SHD2_k127_7944610_62 Ndr family K01055 - 3.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001917 274.0
SHD2_k127_7944610_63 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004869 273.0
SHD2_k127_7944610_64 DSBA-like thioredoxin domain K14584 - 5.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000001637 269.0
SHD2_k127_7944610_65 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001843 269.0
SHD2_k127_7944610_66 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005191 268.0
SHD2_k127_7944610_67 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001461 268.0
SHD2_k127_7944610_68 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000005636 259.0
SHD2_k127_7944610_69 Cytochrome C biogenesis protein K06196,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000002671 259.0
SHD2_k127_7944610_7 AMP-binding enzyme K12508 - 6.2.1.34 7.251e-256 802.0
SHD2_k127_7944610_70 Diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003344 263.0
SHD2_k127_7944610_71 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000004585 258.0
SHD2_k127_7944610_72 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003616 250.0
SHD2_k127_7944610_73 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000007148 243.0
SHD2_k127_7944610_74 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000000000000000002348 223.0
SHD2_k127_7944610_75 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000006676 222.0
SHD2_k127_7944610_76 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000000000001092 220.0
SHD2_k127_7944610_77 PFAM lipolytic protein G-D-S-L family K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000001244 219.0
SHD2_k127_7944610_78 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000007384 219.0
SHD2_k127_7944610_79 SpoU rRNA Methylase family - - - 0.00000000000000000000000000000000000000000000000000000000001493 214.0
SHD2_k127_7944610_8 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 1.076e-239 761.0
SHD2_k127_7944610_80 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000007326 208.0
SHD2_k127_7944610_81 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000000000000000002869 209.0
SHD2_k127_7944610_82 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000000000000000000000000000004274 199.0
SHD2_k127_7944610_83 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000005804 198.0
SHD2_k127_7944610_84 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000002592 197.0
SHD2_k127_7944610_85 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000001375 195.0
SHD2_k127_7944610_86 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000000000000000008222 198.0
SHD2_k127_7944610_87 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000009305 197.0
SHD2_k127_7944610_88 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000008283 186.0
SHD2_k127_7944610_89 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000001086 184.0
SHD2_k127_7944610_9 FtsX-like permease family K02004 - - 2.29e-231 742.0
SHD2_k127_7944610_90 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000001412 190.0
SHD2_k127_7944610_91 nuclease activity K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000000000004816 193.0
SHD2_k127_7944610_92 NAD(P)H-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000002147 179.0
SHD2_k127_7944610_93 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000003379 177.0
SHD2_k127_7944610_94 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000405 169.0
SHD2_k127_7944610_95 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000005019 163.0
SHD2_k127_7944610_96 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000003865 159.0
SHD2_k127_7944610_97 PAS domain - - - 0.000000000000000000000000000000000000001462 153.0
SHD2_k127_7944610_98 MOSC domain - - - 0.000000000000000000000000000000000000005288 149.0
SHD2_k127_7944610_99 Glutathione peroxidase K02199 - - 0.00000000000000000000000000000000000007338 151.0
SHD2_k127_7987113_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 6.079e-220 698.0
SHD2_k127_7987113_1 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 615.0
SHD2_k127_7987113_10 Alpha beta hydrolase K14731 - 3.1.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003198 278.0
SHD2_k127_7987113_11 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007679 269.0
SHD2_k127_7987113_12 Nitronate monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003124 257.0
SHD2_k127_7987113_13 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000159 276.0
SHD2_k127_7987113_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000005209 226.0
SHD2_k127_7987113_15 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000001123 189.0
SHD2_k127_7987113_16 Haem-degrading - - - 0.0000000000000407 81.0
SHD2_k127_7987113_17 BetI-type transcriptional repressor, C-terminal - - - 0.000000000005593 74.0
SHD2_k127_7987113_18 lactoylglutathione lyase activity K05606 - 5.1.99.1 0.000000963 57.0
SHD2_k127_7987113_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 541.0
SHD2_k127_7987113_20 - - - - 0.0001116 51.0
SHD2_k127_7987113_3 Pfam Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 385.0
SHD2_k127_7987113_4 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004298 356.0
SHD2_k127_7987113_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 357.0
SHD2_k127_7987113_6 PFAM Amidohydrolase 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 344.0
SHD2_k127_7987113_7 Belongs to the GST superfamily K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 316.0
SHD2_k127_7987113_8 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 306.0
SHD2_k127_7987113_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009763 299.0
SHD2_k127_8208926_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1002.0
SHD2_k127_8208926_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 1.461e-277 864.0
SHD2_k127_8208926_10 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003976 446.0
SHD2_k127_8208926_11 Binding-protein-dependent transport system inner membrane component K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 436.0
SHD2_k127_8208926_12 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000909 444.0
SHD2_k127_8208926_13 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006035 424.0
SHD2_k127_8208926_14 ABC transporter K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008083 414.0
SHD2_k127_8208926_15 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 406.0
SHD2_k127_8208926_16 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007906 395.0
SHD2_k127_8208926_17 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 388.0
SHD2_k127_8208926_18 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 379.0
SHD2_k127_8208926_19 phosphate transport system permease K02038 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 365.0
SHD2_k127_8208926_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.552e-232 725.0
SHD2_k127_8208926_20 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 364.0
SHD2_k127_8208926_21 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 359.0
SHD2_k127_8208926_22 Chromosome partitioning protein ParA K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 361.0
SHD2_k127_8208926_23 PFAM pfkB family carbohydrate kinase K00847,K00856 - 2.7.1.20,2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 355.0
SHD2_k127_8208926_24 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 322.0
SHD2_k127_8208926_25 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 317.0
SHD2_k127_8208926_26 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 321.0
SHD2_k127_8208926_27 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008054 317.0
SHD2_k127_8208926_28 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009985 313.0
SHD2_k127_8208926_29 MltA specific insert domain K08304 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007863 310.0
SHD2_k127_8208926_3 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 8.397e-202 649.0
SHD2_k127_8208926_30 Acetyltransferase (GNAT) domain K22310 - 2.3.2.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 304.0
SHD2_k127_8208926_31 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 312.0
SHD2_k127_8208926_32 PFAM Phosphate-selective porin O and P K07221 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 307.0
SHD2_k127_8208926_33 Methyltransferase K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 293.0
SHD2_k127_8208926_34 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001515 286.0
SHD2_k127_8208926_35 Periplasmic binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004384 291.0
SHD2_k127_8208926_36 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001128 280.0
SHD2_k127_8208926_37 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001958 279.0
SHD2_k127_8208926_38 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005235 270.0
SHD2_k127_8208926_39 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001505 268.0
SHD2_k127_8208926_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 1.06e-196 627.0
SHD2_k127_8208926_40 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000001631 260.0
SHD2_k127_8208926_41 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000242 254.0
SHD2_k127_8208926_42 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003528 256.0
SHD2_k127_8208926_43 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000001716 245.0
SHD2_k127_8208926_44 Molybdenum ABC transporter K02020 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030151,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0034220,GO:0042597,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043169,GO:0043225,GO:0043492,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0099133,GO:1901359 - 0.0000000000000000000000000000000000000000000000000000000000000000000002858 247.0
SHD2_k127_8208926_45 EamA-like transporter family K08978 - - 0.0000000000000000000000000000000000000000000000000000000000000001183 224.0
SHD2_k127_8208926_46 Uncharacterised protein family (UPF0093) K08973 - - 0.000000000000000000000000000000000000000000000000000001252 196.0
SHD2_k127_8208926_47 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000001505 198.0
SHD2_k127_8208926_48 - - - - 0.000000000000000000000000000000000000000000000000000003226 194.0
SHD2_k127_8208926_49 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000009066 194.0
SHD2_k127_8208926_5 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 484.0
SHD2_k127_8208926_50 import inner membrane translocase, subunit Tim44 - - - 0.00000000000000000000000000000000000000000000000001747 194.0
SHD2_k127_8208926_51 Uncharacterized protein family, UPF0114 - - - 0.00000000000000000000000000000000000000000000000002113 187.0
SHD2_k127_8208926_52 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000002482 188.0
SHD2_k127_8208926_53 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000000000000003762 185.0
SHD2_k127_8208926_54 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000003355 175.0
SHD2_k127_8208926_55 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000000000000000000000000000000000000000000001133 174.0
SHD2_k127_8208926_56 Recombinase - - - 0.0000000000000000000000000000000000000002699 161.0
SHD2_k127_8208926_57 Etoposide-induced protein 2.4 (EI24) K06203 - - 0.00000000000000000000000000000006924 133.0
SHD2_k127_8208926_58 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000000000000002993 127.0
SHD2_k127_8208926_59 protein conserved in bacteria - - - 0.0000000000000000000000000004002 122.0
SHD2_k127_8208926_6 PFAM Major Facilitator Superfamily K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 492.0
SHD2_k127_8208926_60 Integral membrane protein (DUF2244) - - - 0.000000000000000000000000000865 119.0
SHD2_k127_8208926_61 domain, Protein - - - 0.00000000000000002631 85.0
SHD2_k127_8208926_62 Protein of unknown function (DUF3311) - - - 0.000000000000001707 79.0
SHD2_k127_8208926_63 - - - - 0.000000000000003721 83.0
SHD2_k127_8208926_64 - - - - 0.000000000000007514 87.0
SHD2_k127_8208926_65 His Kinase A (phosphoacceptor) domain - - - 0.0000005997 59.0
SHD2_k127_8208926_67 - - - - 0.0006003 48.0
SHD2_k127_8208926_7 Major facilitator superfamily K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000067 489.0
SHD2_k127_8208926_8 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 489.0
SHD2_k127_8208926_9 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 452.0
SHD2_k127_826958_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.618e-275 867.0
SHD2_k127_826958_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 7.669e-267 841.0
SHD2_k127_826958_10 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000001342 201.0
SHD2_k127_826958_11 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874,K01890,K04566,K06878 - 6.1.1.10,6.1.1.20,6.1.1.6 0.0000000000000000000000000000000000000000000000001304 178.0
SHD2_k127_826958_12 - - - - 0.000000000000000000000000000000000000000000000000679 177.0
SHD2_k127_826958_13 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000001644 174.0
SHD2_k127_826958_14 Putative esterase - - - 0.0000000004272 63.0
SHD2_k127_826958_2 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 6.808e-251 789.0
SHD2_k127_826958_3 PFAM Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009896 514.0
SHD2_k127_826958_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 499.0
SHD2_k127_826958_5 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 469.0
SHD2_k127_826958_6 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 422.0
SHD2_k127_826958_7 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 319.0
SHD2_k127_826958_8 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000001482 257.0
SHD2_k127_826958_9 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000001705 238.0
SHD2_k127_858541_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 0.0 1044.0
SHD2_k127_858541_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.237e-264 839.0
SHD2_k127_858541_10 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 501.0
SHD2_k127_858541_11 Belongs to the CarA family K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008424 514.0
SHD2_k127_858541_12 MaoC like domain K14449 GO:0003674,GO:0003824,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046395,GO:0071704,GO:0072329,GO:1901575 4.2.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000649 492.0
SHD2_k127_858541_13 DegT/DnrJ/EryC1/StrS aminotransferase family K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007311 477.0
SHD2_k127_858541_14 FAD binding domain K03185 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 475.0
SHD2_k127_858541_15 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 480.0
SHD2_k127_858541_16 Metallophosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 451.0
SHD2_k127_858541_17 Electron transfer flavoprotein domain K03522 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005113 443.0
SHD2_k127_858541_18 Prephenate dehydrogenase K00210,K00220,K04517 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 435.0
SHD2_k127_858541_19 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 428.0
SHD2_k127_858541_2 DNA segregation ATPase FtsK SpoIIIE and related proteins K03466 - - 2.486e-247 788.0
SHD2_k127_858541_20 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 427.0
SHD2_k127_858541_21 Aminotransferase class I and II K14261,K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 425.0
SHD2_k127_858541_22 Domain of unknown function (DUF4175) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 442.0
SHD2_k127_858541_23 Enoyl-(Acyl carrier protein) reductase K00208 GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 403.0
SHD2_k127_858541_24 AFG1-like ATPase K06916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 402.0
SHD2_k127_858541_25 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 394.0
SHD2_k127_858541_26 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 401.0
SHD2_k127_858541_27 Transport of potassium into the cell - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 385.0
SHD2_k127_858541_28 carboxylic ester hydrolase activity K03929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 384.0
SHD2_k127_858541_29 Winged helix DNA-binding domain K09927 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 378.0
SHD2_k127_858541_3 Belongs to the beta-ketoacyl-ACP synthases family K00647 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 3.813e-199 628.0
SHD2_k127_858541_30 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 - 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 367.0
SHD2_k127_858541_31 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 370.0
SHD2_k127_858541_32 Belongs to the HpcH HpaI aldolase family K01644,K14451 - 3.1.2.30,4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 360.0
SHD2_k127_858541_33 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005855 363.0
SHD2_k127_858541_34 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003917 352.0
SHD2_k127_858541_35 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 342.0
SHD2_k127_858541_36 Glutathione S-transferase, C-terminal domain K00799,K03599 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 339.0
SHD2_k127_858541_37 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 322.0
SHD2_k127_858541_38 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009882 325.0
SHD2_k127_858541_39 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 318.0
SHD2_k127_858541_4 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 608.0
SHD2_k127_858541_40 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009626 310.0
SHD2_k127_858541_41 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 300.0
SHD2_k127_858541_42 COG1592 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006641 262.0
SHD2_k127_858541_43 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59,5.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000002474 254.0
SHD2_k127_858541_44 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003382 256.0
SHD2_k127_858541_45 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000004749 242.0
SHD2_k127_858541_46 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005256 248.0
SHD2_k127_858541_47 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000001215 241.0
SHD2_k127_858541_48 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000000000000000000000003411 216.0
SHD2_k127_858541_49 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000002293 213.0
SHD2_k127_858541_5 Cysteine-rich domain K00113 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004718 605.0
SHD2_k127_858541_50 Belongs to the P(II) protein family K04751,K04752 - - 0.000000000000000000000000000000000000000000000000000007978 190.0
SHD2_k127_858541_52 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000000000000000000001942 190.0
SHD2_k127_858541_53 Putative zinc-finger - - - 0.0000000000000000000000000000000000000000000000002696 186.0
SHD2_k127_858541_54 hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000008097 183.0
SHD2_k127_858541_55 Domain of unknown function (DUF1993) K09983 - - 0.000000000000000000000000000000000000000000000001052 180.0
SHD2_k127_858541_56 Belongs to the Fur family K09826 - - 0.000000000000000000000000000000000000000000000001328 178.0
SHD2_k127_858541_57 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000000005879 177.0
SHD2_k127_858541_58 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000004299 173.0
SHD2_k127_858541_59 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000001516 179.0
SHD2_k127_858541_6 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 593.0
SHD2_k127_858541_60 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000006299 169.0
SHD2_k127_858541_61 chorismate mutase - - - 0.00000000000000000000000000000000000000000008375 170.0
SHD2_k127_858541_62 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000003818 165.0
SHD2_k127_858541_63 Cell division protein K09811 - - 0.000000000000000000000000000000000000000486 160.0
SHD2_k127_858541_64 DUF218 domain - - - 0.0000000000000000000000000000000000000005864 155.0
SHD2_k127_858541_65 membrane - - - 0.000000000000000000000000000000000007367 141.0
SHD2_k127_858541_66 DJ-1/PfpI family - - - 0.0000000000000000000000000000000004562 148.0
SHD2_k127_858541_67 Protein of unknown function (DUF992) - - - 0.00000000000000000000000000000003425 140.0
SHD2_k127_858541_68 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8 0.000000000000000000000000000000776 128.0
SHD2_k127_858541_69 Bacterial PH domain - - - 0.000000000000000000000000000001764 126.0
SHD2_k127_858541_7 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 550.0
SHD2_k127_858541_70 Putative adhesin - - - 0.000000000000000000000000000002114 134.0
SHD2_k127_858541_71 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000002394 130.0
SHD2_k127_858541_72 protein encoded in hypervariable junctions of pilus gene clusters - - - 0.000000000000000000000000000007447 123.0
SHD2_k127_858541_73 Cytochrome c2 K08738 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000005303 121.0
SHD2_k127_858541_74 Domain of unknown function (DUF4893) - - - 0.000000000000000000000000009457 119.0
SHD2_k127_858541_75 Putative toxin of bacterial toxin-antitoxin pair K09982 - - 0.000000000000000000000000144 109.0
SHD2_k127_858541_76 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000009596 107.0
SHD2_k127_858541_77 Cupin 2, conserved barrel - - - 0.000000000000000000000002559 108.0
SHD2_k127_858541_78 Dodecin K09165 - - 0.00000000000000000000002486 105.0
SHD2_k127_858541_79 Peptidase propeptide and YPEB domain - - - 0.000000000000000000004219 103.0
SHD2_k127_858541_8 Ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005936 544.0
SHD2_k127_858541_80 PAS domain - - - 0.00000000004244 70.0
SHD2_k127_858541_81 Uncharacterized protein conserved in bacteria (DUF2125) - - - 0.000000001813 69.0
SHD2_k127_858541_82 PAS domain - - - 0.000004676 56.0
SHD2_k127_858541_9 acyl-CoA transferases carnitine dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009161 515.0