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Overview

ID MAG03976
Name TLS1_bin.3
Sample SMP0103
Taxonomy
Kingdom Bacteria
Phylum Chloroflexota
Class Limnocylindria
Order Limnocylindrales
Family CSP1-4
Genus CF-46
Species
Assembly information
Completeness (%) 74.98
Contamination (%) 1.71
GC content (%) 71.0
N50 (bp) 15,675
Genome size (bp) 2,920,801

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2525

Gene name Description KEGG GOs EC E-value Score Sequence
TLS1_k127_1022572_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 5.464e-219 687.0
TLS1_k127_1022572_1 Peptidase dimerisation domain K01436,K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 511.0
TLS1_k127_1022572_2 Participates in initiation and elongation during chromosome replication K02314,K02316,K17680 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000003687 251.0
TLS1_k127_1022572_3 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000007411 181.0
TLS1_k127_1022572_4 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000123 119.0
TLS1_k127_103898_0 Heat shock 70 kDa protein K04043 - - 1.261e-256 807.0
TLS1_k127_103898_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 448.0
TLS1_k127_103898_2 Cation transport protein K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 381.0
TLS1_k127_103898_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002454 267.0
TLS1_k127_103898_4 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001798 262.0
TLS1_k127_103898_5 TrkA-C domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000002096 220.0
TLS1_k127_103898_6 COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase K02548 - 2.5.1.74 0.00000000000000000000000000000000002337 154.0
TLS1_k127_103898_7 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000008475 126.0
TLS1_k127_103898_8 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.00000000000000000008562 90.0
TLS1_k127_103898_9 coenzyme F420 binding - - - 0.0000003469 58.0
TLS1_k127_1045609_0 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 0.0 1022.0
TLS1_k127_1045609_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 434.0
TLS1_k127_1045609_11 Transglycosylase SLT domain K08307 - - 0.00008754 53.0
TLS1_k127_1045609_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 413.0
TLS1_k127_1045609_3 SMART Nucleotide binding protein, PINc - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 302.0
TLS1_k127_1045609_4 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006591 314.0
TLS1_k127_1045609_5 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000002313 213.0
TLS1_k127_1045609_6 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000002885 208.0
TLS1_k127_1045609_7 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000001098 130.0
TLS1_k127_1045609_8 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000003286 84.0
TLS1_k127_1056910_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 375.0
TLS1_k127_1056910_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 360.0
TLS1_k127_1056910_2 PFAM Metallophosphoesterase K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 295.0
TLS1_k127_1056910_3 Membrane protein TerC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 289.0
TLS1_k127_1056910_4 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000003405 203.0
TLS1_k127_1056910_5 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000001854 188.0
TLS1_k127_1056910_6 Endoribonuclease that initiates mRNA decay K18682 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000001055 154.0
TLS1_k127_1056910_7 - - - - 0.00000000000000000000000000000000002477 147.0
TLS1_k127_1085222_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 6.016e-224 726.0
TLS1_k127_1085222_1 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004672 592.0
TLS1_k127_1085222_10 Binding-protein-dependent transport system inner membrane component K02018,K02046 - - 0.0000000000000000000000000000000000000000000000000000000000000000001062 241.0
TLS1_k127_1085222_11 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000151 198.0
TLS1_k127_1085222_12 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000003804 186.0
TLS1_k127_1085222_13 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000001063 171.0
TLS1_k127_1085222_14 PFAM glycoside hydrolase, family 3 domain protein K01207 - 3.2.1.52 0.0000000000000000000000000000000000001221 148.0
TLS1_k127_1085222_15 Polysaccharide deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000000000000006216 152.0
TLS1_k127_1085222_16 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000001022 160.0
TLS1_k127_1085222_17 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000388 152.0
TLS1_k127_1085222_18 DNA binding domain - - - 0.0000000000000000000000000002106 119.0
TLS1_k127_1085222_19 redox protein regulator of disulfide bond formation K07397 - - 0.0000000000000000000000002278 117.0
TLS1_k127_1085222_2 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 555.0
TLS1_k127_1085222_20 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.000000000000000000000002372 114.0
TLS1_k127_1085222_21 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000002808 104.0
TLS1_k127_1085222_22 Aminoacyl-tRNA editing domain K19055 - - 0.0000000000000000000003326 106.0
TLS1_k127_1085222_23 helix_turn_helix, mercury resistance - - - 0.0000000000000000000009198 104.0
TLS1_k127_1085222_24 Sulfurtransferase TusA - - - 0.000000000000000000002036 101.0
TLS1_k127_1085222_25 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000000000002468 90.0
TLS1_k127_1085222_26 Universal stress protein family - - - 0.0000000000000002848 85.0
TLS1_k127_1085222_27 Transcriptional regulator, arsR family - - - 0.000000000000001762 81.0
TLS1_k127_1085222_28 Helix-turn-helix XRE-family like proteins - - - 0.0000009259 61.0
TLS1_k127_1085222_29 Cro/C1-type HTH DNA-binding domain - - - 0.0002281 47.0
TLS1_k127_1085222_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 443.0
TLS1_k127_1085222_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007581 420.0
TLS1_k127_1085222_5 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 414.0
TLS1_k127_1085222_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 310.0
TLS1_k127_1085222_7 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 315.0
TLS1_k127_1085222_8 Galactokinase galactose-binding signature K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 318.0
TLS1_k127_1085222_9 SIS domain K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 304.0
TLS1_k127_1092064_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 3.807e-215 693.0
TLS1_k127_1092064_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000005268 145.0
TLS1_k127_1092064_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000001006 126.0
TLS1_k127_1092064_3 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000009916 79.0
TLS1_k127_1092064_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000003527 61.0
TLS1_k127_1092064_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000004489 52.0
TLS1_k127_1092064_6 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.00000695 52.0
TLS1_k127_1098823_0 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 462.0
TLS1_k127_1098823_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 413.0
TLS1_k127_1098823_10 Septum formation - - - 0.000000000005373 78.0
TLS1_k127_1098823_11 AAA ATPase domain - - - 0.00004587 46.0
TLS1_k127_1098823_12 Protein of unknown function (DUF433) - - - 0.0001281 53.0
TLS1_k127_1098823_2 COG0147 Anthranilate para-aminobenzoate synthases component I K01665 - 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 352.0
TLS1_k127_1098823_3 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 313.0
TLS1_k127_1098823_4 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001606 282.0
TLS1_k127_1098823_5 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000003093 184.0
TLS1_k127_1098823_6 COGs COG2912 conserved - - - 0.00000000000000000000000000000000000000000003496 172.0
TLS1_k127_1098823_7 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000006086 141.0
TLS1_k127_1098823_8 Acetyltransferase (GNAT) domain - - - 0.000000000000001016 91.0
TLS1_k127_1098823_9 Septum formation - - - 0.0000000000001878 77.0
TLS1_k127_1125930_0 ABC transporter - - - 0.0 1148.0
TLS1_k127_1125930_1 CoA binding domain K09181 - - 3.513e-220 697.0
TLS1_k127_1125930_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000007499 203.0
TLS1_k127_1125930_11 PFAM Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000001999 207.0
TLS1_k127_1125930_12 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000002823 193.0
TLS1_k127_1125930_13 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000003122 202.0
TLS1_k127_1125930_14 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000002248 188.0
TLS1_k127_1125930_15 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000000000000000000000000005877 179.0
TLS1_k127_1125930_16 TspO/MBR family K05770 - - 0.000000000000000000000000000000000000000000000001472 183.0
TLS1_k127_1125930_17 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000006282 186.0
TLS1_k127_1125930_18 gtp1 obg K06944 - - 0.000000000000000000000000000000000000000000001505 178.0
TLS1_k127_1125930_19 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000002372 175.0
TLS1_k127_1125930_2 luciferase-like monooxygenase - - - 1.04e-216 675.0
TLS1_k127_1125930_20 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000002187 165.0
TLS1_k127_1125930_21 PFAM Bacterial regulatory protein, arsR family - - - 0.0000000000000000000000000000000000000000001378 161.0
TLS1_k127_1125930_22 - - - - 0.00000000000000000000000000000000000000002892 164.0
TLS1_k127_1125930_23 Acetyltransferase (GNAT) domain K17840 - 2.3.1.59 0.00000000000000000000000000000000000000008605 163.0
TLS1_k127_1125930_24 Domain of unknown function (DU1801) - - - 0.000000000000000000000002006 113.0
TLS1_k127_1125930_25 Cupin 2, conserved barrel domain protein - - - 0.000000000000006143 82.0
TLS1_k127_1125930_27 - - - - 0.00004338 53.0
TLS1_k127_1125930_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 433.0
TLS1_k127_1125930_4 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001532 276.0
TLS1_k127_1125930_5 Kelch motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001887 284.0
TLS1_k127_1125930_6 NADPH-dependent FMN reductase K00299 - 1.5.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000006448 249.0
TLS1_k127_1125930_7 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000001009 241.0
TLS1_k127_1125930_8 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000003452 208.0
TLS1_k127_1125930_9 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000004295 207.0
TLS1_k127_1155706_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 1.257e-212 674.0
TLS1_k127_1155706_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 434.0
TLS1_k127_1155706_10 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000008159 213.0
TLS1_k127_1155706_11 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000002119 207.0
TLS1_k127_1155706_12 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000001092 191.0
TLS1_k127_1155706_13 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000007348 156.0
TLS1_k127_1155706_14 Regulates arginine biosynthesis genes K03402 - - 0.00000000000000000000000000001299 126.0
TLS1_k127_1155706_15 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000000007518 118.0
TLS1_k127_1155706_16 RDD family - - - 0.00000000000000001714 92.0
TLS1_k127_1155706_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 434.0
TLS1_k127_1155706_3 tRNA binding K04566 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 436.0
TLS1_k127_1155706_4 Trehalose utilization protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000432 374.0
TLS1_k127_1155706_5 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 318.0
TLS1_k127_1155706_6 transferase activity, transferring glycosyl groups K00713,K06338 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001779 289.0
TLS1_k127_1155706_7 Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004785 278.0
TLS1_k127_1155706_8 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003556 279.0
TLS1_k127_1155706_9 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000984 239.0
TLS1_k127_1155709_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006647 489.0
TLS1_k127_1155709_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000001013 191.0
TLS1_k127_1155709_2 TIGRFAM signal peptidase I, bacterial type K03100 - 3.4.21.89 0.000000000000000000000000000001539 132.0
TLS1_k127_1155709_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000002243 68.0
TLS1_k127_1176995_0 TIGRFAM cysteine desulfurase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 435.0
TLS1_k127_1176995_1 PFAM Glucose Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 391.0
TLS1_k127_1176995_2 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000006022 275.0
TLS1_k127_1176995_3 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000002269 236.0
TLS1_k127_1176995_4 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000005282 167.0
TLS1_k127_1176995_5 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.0000000000000000000000000000000000007387 157.0
TLS1_k127_1176995_6 transcriptional regulator (MarR - - - 0.000000000000000000000000000000005845 148.0
TLS1_k127_1176995_7 Cupin domain - - - 0.00000000000000000000000000000005025 134.0
TLS1_k127_1176995_8 Protein of unknown function (DUF541) K09807 - - 0.00007865 48.0
TLS1_k127_1184474_0 Two component transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000001382 157.0
TLS1_k127_1184474_1 Protein of unknown function (DUF642) - - - 0.000000000000000000000001703 116.0
TLS1_k127_1204362_0 PhoD-like phosphatase - - - 0.000000000000000000000000000000000000000000000001146 194.0
TLS1_k127_1227853_0 CoA carboxylase activity K01968 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 524.0
TLS1_k127_1227853_1 transferase activity, transferring glycosyl groups K09118,K13693,K21349 - 2.4.1.266,2.4.1.268 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006499 456.0
TLS1_k127_1227853_10 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000006148 187.0
TLS1_k127_1227853_11 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000356 145.0
TLS1_k127_1227853_12 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 0.0000000000000000000000001642 123.0
TLS1_k127_1227853_13 PFAM TadE family protein - - - 0.00000008592 59.0
TLS1_k127_1227853_14 dna ligase - - - 0.0001602 52.0
TLS1_k127_1227853_15 domain protein - - - 0.0002001 52.0
TLS1_k127_1227853_2 Glycosyl transferase, family 2 K21349 - 2.4.1.268 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 391.0
TLS1_k127_1227853_3 tRNA nucleotidyltransferase domain 2 putative K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008372 343.0
TLS1_k127_1227853_4 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 334.0
TLS1_k127_1227853_5 PFAM pyruvate carboxyltransferase K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 302.0
TLS1_k127_1227853_6 Belongs to the glycerate kinase type-1 family K00865 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000002894 276.0
TLS1_k127_1227853_7 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003335 257.0
TLS1_k127_1227853_8 HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000008632 209.0
TLS1_k127_1227853_9 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000003052 176.0
TLS1_k127_1248022_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009915 357.0
TLS1_k127_1248022_1 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000001272 199.0
TLS1_k127_1248022_2 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000002497 79.0
TLS1_k127_1341796_0 E1-E2 ATPase K01533 - 3.6.3.4 1.146e-258 815.0
TLS1_k127_1341796_1 AMP-dependent synthetase and ligase K01895 - 6.2.1.1 2.549e-238 754.0
TLS1_k127_1341796_10 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit - - - 0.0000000000000000000007046 111.0
TLS1_k127_1341796_11 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.00000000000000001313 89.0
TLS1_k127_1341796_13 Calcineurin-like phosphoesterase - - - 0.0006651 42.0
TLS1_k127_1341796_2 Trimethylamine methyltransferase (MTTB) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 616.0
TLS1_k127_1341796_3 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 477.0
TLS1_k127_1341796_4 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000000000002598 217.0
TLS1_k127_1341796_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000005378 198.0
TLS1_k127_1341796_6 D-aminopeptidase K16203 - - 0.0000000000000000000000000000000000000000000000002359 186.0
TLS1_k127_1341796_7 Molybdopterin converting factor subunit K03635,K21142 - 2.8.1.12 0.000000000000000000000000000000000000000006345 171.0
TLS1_k127_1341796_8 PFAM response regulator receiver - - - 0.0000000000000000000000000000000001229 144.0
TLS1_k127_1341796_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000009304 123.0
TLS1_k127_1342467_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 1.781e-211 670.0
TLS1_k127_1342467_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007839 370.0
TLS1_k127_1342467_10 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000009071 79.0
TLS1_k127_1342467_11 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000004658 63.0
TLS1_k127_1342467_12 Peptidase family S51 - - - 0.0000003273 61.0
TLS1_k127_1342467_13 COG2133 Glucose sorbosone dehydrogenases - - - 0.00005877 55.0
TLS1_k127_1342467_2 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 312.0
TLS1_k127_1342467_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000001252 246.0
TLS1_k127_1342467_4 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000002383 199.0
TLS1_k127_1342467_5 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351,K07245 - - 0.0000000000000000000000000000000000000000000000000003289 202.0
TLS1_k127_1342467_6 COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 - 1.9.3.1 0.000000000000000000000000000000000000000225 160.0
TLS1_k127_1342467_7 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000004276 158.0
TLS1_k127_1342467_8 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.000000000000000000000000000000000000215 159.0
TLS1_k127_1342467_9 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.0000000000000000000000002876 111.0
TLS1_k127_1352980_0 Domain of unknown function (DUF4082) - - - 0.0 1579.0
TLS1_k127_1352980_1 Domain of unknown function (DUF4082) - - - 0.000000000000000000000000000000000000000000000000005869 211.0
TLS1_k127_1379197_0 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 602.0
TLS1_k127_1379197_1 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 530.0
TLS1_k127_1379197_10 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000002315 220.0
TLS1_k127_1379197_11 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000004432 200.0
TLS1_k127_1379197_12 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.000000000000000000000000000000000000000000000000006165 183.0
TLS1_k127_1379197_13 Cro/C1-type HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000001675 188.0
TLS1_k127_1379197_14 PFAM Diacylglycerol kinase, catalytic - - - 0.000000000000000000000000000000000000000000000006249 194.0
TLS1_k127_1379197_15 inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000001623 190.0
TLS1_k127_1379197_16 Acid phosphatase homologues - - - 0.00000000000000000000000000000000000000000004659 173.0
TLS1_k127_1379197_17 Uncharacterized protein conserved in bacteria (DUF2087) - - - 0.000000000000000000001858 103.0
TLS1_k127_1379197_18 RES - - - 0.000000000000004194 86.0
TLS1_k127_1379197_2 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 481.0
TLS1_k127_1379197_3 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006104 494.0
TLS1_k127_1379197_4 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009575 458.0
TLS1_k127_1379197_5 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005845 444.0
TLS1_k127_1379197_6 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 331.0
TLS1_k127_1379197_7 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 338.0
TLS1_k127_1379197_8 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000001907 267.0
TLS1_k127_1379197_9 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007064 259.0
TLS1_k127_1450512_0 ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005746 533.0
TLS1_k127_1450512_1 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 461.0
TLS1_k127_1450512_10 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000000000000000000002477 120.0
TLS1_k127_1450512_11 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000001522 113.0
TLS1_k127_1450512_12 cyclic nucleotide-binding - - - 0.0000000267 67.0
TLS1_k127_1450512_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 463.0
TLS1_k127_1450512_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 395.0
TLS1_k127_1450512_4 Creatinase/Prolidase N-terminal domain K01271,K01274,K08688 - 3.4.13.9,3.5.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 346.0
TLS1_k127_1450512_5 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008151 254.0
TLS1_k127_1450512_6 malonyl CoA-acyl carrier protein transacylase K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000008707 229.0
TLS1_k127_1450512_7 helix_turn_helix, cAMP Regulatory protein K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.000000000000000000000000000000000000000000003044 173.0
TLS1_k127_1450512_8 Major facilitator superfamily - - - 0.00000000000000000000000000000007962 143.0
TLS1_k127_1450512_9 GAF domain - - - 0.000000000000000000000001059 115.0
TLS1_k127_1479398_0 malic protein domain protein K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 601.0
TLS1_k127_1479398_1 ATP dependent DNA ligase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 471.0
TLS1_k127_1479398_10 Domain of unknown function (DUF4349) - - - 0.000000000000000000000005856 116.0
TLS1_k127_1479398_11 Methyltransferase type 11 - - - 0.00000000001595 77.0
TLS1_k127_1479398_12 PASTA - - - 0.00000000916 63.0
TLS1_k127_1479398_13 COG3209 Rhs family protein K20276 - - 0.00003483 56.0
TLS1_k127_1479398_2 Pterin binding enzyme K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004786 300.0
TLS1_k127_1479398_3 Domain present in PSD-95, Dlg, and ZO-1/2. K04771,K08070 - 1.3.1.74,3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000002043 258.0
TLS1_k127_1479398_4 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000001889 254.0
TLS1_k127_1479398_5 response regulator receiver K07658,K07668 - - 0.0000000000000000000000000000000000000000000000000000000000000002559 227.0
TLS1_k127_1479398_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000007502 187.0
TLS1_k127_1479398_7 Domain of unknown function (DUF4173) - - - 0.00000000000000000000000000000000000003081 166.0
TLS1_k127_1479398_8 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000004547 138.0
TLS1_k127_1479398_9 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000005975 116.0
TLS1_k127_1483345_0 Isocitrate lyase K01637 GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350 4.1.3.1 0.0 1032.0
TLS1_k127_1483345_1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 632.0
TLS1_k127_1483345_10 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 325.0
TLS1_k127_1483345_11 Starch synthase catalytic domain K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 317.0
TLS1_k127_1483345_12 periplasmic binding protein LacI transcriptional regulator K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005926 287.0
TLS1_k127_1483345_13 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000003136 248.0
TLS1_k127_1483345_14 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000003581 235.0
TLS1_k127_1483345_15 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000006222 223.0
TLS1_k127_1483345_16 PFAM sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000002312 218.0
TLS1_k127_1483345_17 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000001367 113.0
TLS1_k127_1483345_18 carboxylic ester hydrolase activity - - - 0.00000000000000000000004508 110.0
TLS1_k127_1483345_19 - - - - 0.0000000000000008611 90.0
TLS1_k127_1483345_2 Glycosyl hydrolase family 65 central catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005348 579.0
TLS1_k127_1483345_20 PFAM amino acid-binding ACT domain protein - - - 0.0000000000001119 76.0
TLS1_k127_1483345_21 - - - - 0.00000000000111 76.0
TLS1_k127_1483345_3 Alpha-amylase domain K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 472.0
TLS1_k127_1483345_4 SMART alpha amylase, catalytic sub domain K01176 - 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006486 464.0
TLS1_k127_1483345_5 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 425.0
TLS1_k127_1483345_6 PFAM extracellular solute-binding protein family 1 K15770 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 379.0
TLS1_k127_1483345_7 transcriptional regulator K13633 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 361.0
TLS1_k127_1483345_8 PFAM binding-protein-dependent transport systems inner membrane component K15772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006337 332.0
TLS1_k127_1483345_9 PFAM binding-protein-dependent transport systems inner membrane component K15771 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009461 336.0
TLS1_k127_1484095_0 regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 309.0
TLS1_k127_1484095_1 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000169 193.0
TLS1_k127_1484095_2 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000008252 165.0
TLS1_k127_1484095_3 Sugar transferase - - - 0.000000000000000000000000000000005571 144.0
TLS1_k127_1484095_4 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000001217 116.0
TLS1_k127_15375_0 PFAM isocitrate isopropylmalate dehydrogenase K00030,K07246 - 1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009974 487.0
TLS1_k127_15375_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009604 413.0
TLS1_k127_15375_10 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000001053 86.0
TLS1_k127_15375_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009372 389.0
TLS1_k127_15375_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 338.0
TLS1_k127_15375_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 295.0
TLS1_k127_15375_5 succinate dehydrogenase, flavoprotein subunit K00239 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000005121 199.0
TLS1_k127_15375_6 Putative heavy-metal-binding - - - 0.0000000000000000000000000000000000000000407 159.0
TLS1_k127_15375_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000001901 135.0
TLS1_k127_15375_8 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.000000000000000000000002463 108.0
TLS1_k127_15375_9 2'-5' RNA ligase superfamily - - - 0.00000000000000001282 91.0
TLS1_k127_1572865_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 1.268e-263 820.0
TLS1_k127_1572865_1 BFD domain protein 2Fe-2S -binding domain protein K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 512.0
TLS1_k127_1572865_10 RNA pseudouridylate synthase K06178,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 0.00000000000000000000000000000000000000000000002339 190.0
TLS1_k127_1572865_11 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000002735 190.0
TLS1_k127_1572865_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000004026 146.0
TLS1_k127_1572865_13 PFAM peptidase M50 - - - 0.000000000000000000000000000000004319 136.0
TLS1_k127_1572865_14 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000004404 142.0
TLS1_k127_1572865_15 PFAM membrane-flanked domain - - - 0.00000000000000000000000000000229 131.0
TLS1_k127_1572865_16 Glycerol-3-phosphate responsive antiterminator K02443 - - 0.000000000000000000000002317 110.0
TLS1_k127_1572865_17 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000005185 109.0
TLS1_k127_1572865_18 mRNA catabolic process - - - 0.000000000000001902 83.0
TLS1_k127_1572865_19 Glycerol-3-phosphate responsive antiterminator K02443 - - 0.00001617 55.0
TLS1_k127_1572865_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000651 451.0
TLS1_k127_1572865_3 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 370.0
TLS1_k127_1572865_4 Belongs to the MIP aquaporin (TC 1.A.8) family K02440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007363 328.0
TLS1_k127_1572865_5 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 323.0
TLS1_k127_1572865_6 recombinase XerD K04763 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001195 278.0
TLS1_k127_1572865_7 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000004914 237.0
TLS1_k127_1572865_8 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000002636 200.0
TLS1_k127_1572865_9 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000949 186.0
TLS1_k127_1574976_0 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009331 395.0
TLS1_k127_1574976_1 PFAM ABC transporter related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000441 285.0
TLS1_k127_1574976_2 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007963 269.0
TLS1_k127_1574976_3 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000003876 195.0
TLS1_k127_1574976_4 Hemerythrin hhe cation binding - - - 0.0000000000000000000000000000000000001799 147.0
TLS1_k127_1574976_5 histidine kinase A domain protein - - - 0.0000000000000000000000000000003734 136.0
TLS1_k127_1574976_6 Double zinc ribbon - - - 0.00000000000000000000005821 104.0
TLS1_k127_1574976_7 Transglycosylase associated protein - - - 0.000000000001485 72.0
TLS1_k127_1598497_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005576 472.0
TLS1_k127_1598497_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 294.0
TLS1_k127_1598497_2 Required for chromosome condensation and partitioning K03529 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000005724 231.0
TLS1_k127_1598497_3 Ribosomal protein S16 K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000005133 116.0
TLS1_k127_1598497_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000003958 96.0
TLS1_k127_1598497_5 Belongs to the UPF0109 family K06960 - - 0.00000000000000001836 91.0
TLS1_k127_1666567_0 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000004965 234.0
TLS1_k127_1666567_1 Cys/Met metabolism PLP-dependent enzyme K11325 - - 0.000000000000000000000000000000000000000000002439 181.0
TLS1_k127_1676902_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009235 308.0
TLS1_k127_1676902_1 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 294.0
TLS1_k127_1676902_2 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002242 291.0
TLS1_k127_1676902_3 Peptidase S9, prolyl oligopeptidase - - - 0.0000000000000000000000000000000000000000000000000001742 213.0
TLS1_k127_1676902_4 Nodulation protein S (NodS) - - - 0.0000000000000000000000008875 120.0
TLS1_k127_1676902_5 Family of unknown function (DUF5317) - - - 0.000000000000000001247 93.0
TLS1_k127_1676902_6 Wyosine base formation - - - 0.0003543 52.0
TLS1_k127_1683900_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 452.0
TLS1_k127_1683900_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 401.0
TLS1_k127_1683900_10 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503 - - 0.00000000000000000000000000000000000000006705 154.0
TLS1_k127_1683900_11 YqeY-like protein K09117 - - 0.000000000000000000000000000000005286 134.0
TLS1_k127_1683900_12 Ribosomal protein S21 K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000008231 84.0
TLS1_k127_1683900_13 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000002978 91.0
TLS1_k127_1683900_2 7TM-HD extracellular K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 392.0
TLS1_k127_1683900_3 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006032 375.0
TLS1_k127_1683900_4 Transport permease protein K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005414 317.0
TLS1_k127_1683900_5 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004466 295.0
TLS1_k127_1683900_6 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001565 285.0
TLS1_k127_1683900_7 Ribosomal protein L11 methyltransferase K02687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007657 260.0
TLS1_k127_1683900_8 ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000000007905 239.0
TLS1_k127_1683900_9 Uncharacterized protein conserved in bacteria (DUF2334) K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000000000000000003689 221.0
TLS1_k127_1711995_0 domain protein K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 461.0
TLS1_k127_1711995_1 Pyridoxal-phosphate dependent enzyme K01883,K12339,K21148 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113,2.5.1.47,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008586 397.0
TLS1_k127_1711995_10 ThiS family K03636 - - 0.0000000000000000000008612 110.0
TLS1_k127_1711995_2 ATPases associated with a variety of cellular activities K16786,K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005687 260.0
TLS1_k127_1711995_3 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006,K16786,K16787 - - 0.00000000000000000000000000000000000000000000000000001669 209.0
TLS1_k127_1711995_4 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000003823 188.0
TLS1_k127_1711995_5 Inosine-uridine preferring nucleoside hydrolase K01239,K01250 - 3.2.2.1 0.0000000000000000000000000000000000000000000002083 173.0
TLS1_k127_1711995_6 phosphorelay sensor kinase activity K16923,K18967 - 2.7.7.65 0.00000000000000000000000000000000000000000008655 174.0
TLS1_k127_1711995_7 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000000000283 153.0
TLS1_k127_1711995_8 PFAM Cobalt transport protein K16785 - - 0.00000000000000000000000000000001648 137.0
TLS1_k127_1711995_9 Mov34 MPN PAD-1 family K21140 - 3.13.1.6 0.000000000000000000000000001992 128.0
TLS1_k127_1717821_0 TIGRFAM methylmalonyl-CoA mutase, large subunit K01848 - 5.4.99.2 4.078e-219 710.0
TLS1_k127_1717821_1 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 380.0
TLS1_k127_1717821_10 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.00000000000000000000000000001565 121.0
TLS1_k127_1717821_11 BAAT Acyl-CoA thioester hydrolase - - - 0.00000000000000000000000007815 121.0
TLS1_k127_1717821_12 Belongs to the peptidase S33 family - - - 0.0000000000003817 79.0
TLS1_k127_1717821_13 transcriptional regulator, ArsR family - - - 0.0000000000004221 73.0
TLS1_k127_1717821_14 Nitroreductase family - - - 0.000000004335 68.0
TLS1_k127_1717821_15 DnaJ molecular chaperone homology domain K03686 - - 0.00000005981 64.0
TLS1_k127_1717821_16 Protein of unknown function (DUF1706) - - - 0.00001017 57.0
TLS1_k127_1717821_2 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001644 280.0
TLS1_k127_1717821_3 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006002 277.0
TLS1_k127_1717821_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003354 263.0
TLS1_k127_1717821_5 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000005215 244.0
TLS1_k127_1717821_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000002512 232.0
TLS1_k127_1717821_7 Lysyl oxidase - - - 0.00000000000000000000000000000000000000000002431 174.0
TLS1_k127_1717821_8 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000004604 149.0
TLS1_k127_1717821_9 Zincin-like metallopeptidase - - - 0.00000000000000000000000000001341 122.0
TLS1_k127_1808358_0 aromatic amino acid beta-eliminating lyase threonine aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 366.0
TLS1_k127_1808358_1 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009956 378.0
TLS1_k127_1808358_10 Glycosyl transferase group 1 - - - 0.00000000000000000000000000000000174 150.0
TLS1_k127_1808358_11 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000003468 132.0
TLS1_k127_1808358_12 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000004092 101.0
TLS1_k127_1808358_13 maltose O-acetyltransferase K00661 - 2.3.1.79 0.00000000000002218 86.0
TLS1_k127_1808358_14 Glycosyl transferases group 1 - - - 0.0000000000008816 81.0
TLS1_k127_1808358_15 COG0438 Glycosyltransferase - - - 0.000000000003826 78.0
TLS1_k127_1808358_2 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K13019 - 5.1.3.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 296.0
TLS1_k127_1808358_3 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000008865 247.0
TLS1_k127_1808358_4 ABC transporter K01990,K09691,K09693 - 3.6.3.40 0.000000000000000000000000000000000000000000000000000000000003432 229.0
TLS1_k127_1808358_5 PFAM transferase hexapeptide repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000001523 219.0
TLS1_k127_1808358_6 PFAM LmbE family protein - - - 0.0000000000000000000000000000000000000000000000000000006515 204.0
TLS1_k127_1808358_7 Transport permease protein K09688,K09690 - - 0.000000000000000000000000000000000000000000275 169.0
TLS1_k127_1808358_8 Protein of unknown function (DUF3048) C-terminal domain - - - 0.000000000000000000000000000000000000000003131 175.0
TLS1_k127_1808358_9 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000006007 157.0
TLS1_k127_1808485_0 PFAM UDP-glucose GDP-mannose dehydrogenase family, NAD binding domain K02472,K13015 - 1.1.1.136,1.1.1.336 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 405.0
TLS1_k127_1808485_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002126 279.0
TLS1_k127_1808485_2 MazG nucleotide pyrophosphohydrolase domain K02428,K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000008481 263.0
TLS1_k127_1808485_3 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000009251 223.0
TLS1_k127_1808485_4 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000000000000009119 222.0
TLS1_k127_1808485_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000003196 180.0
TLS1_k127_1808485_6 4Fe-4S binding domain K00176 - 1.2.7.3 0.000000000000001834 83.0
TLS1_k127_1808485_7 Glycosyl transferases group 1 - - - 0.000000000001441 77.0
TLS1_k127_1808485_8 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000339 70.0
TLS1_k127_1843900_0 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 524.0
TLS1_k127_1843900_1 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 401.0
TLS1_k127_1843900_2 Peptidase inhibitor I9 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 360.0
TLS1_k127_1843900_3 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000009253 261.0
TLS1_k127_1843900_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000006302 228.0
TLS1_k127_1843900_5 Protein of unknown function (DUF3830) - - - 0.000000000000000000000000000000000000003606 151.0
TLS1_k127_1843900_6 - - - - 0.000000000000000000000000006473 124.0
TLS1_k127_1843900_7 phosphorelay signal transduction system - - - 0.000000000000000000000000436 117.0
TLS1_k127_1843900_8 OHCU decarboxylase - - - 0.0000000000000000000000006948 110.0
TLS1_k127_1843900_9 HIUase/Transthyretin family K07127 - 3.5.2.17 0.0000000000000000009194 93.0
TLS1_k127_1946662_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 2.514e-233 731.0
TLS1_k127_1946662_1 geranylgeranyl reductase activity K21401 - 1.3.99.38 0.0000000000000000000000000000000000000000000000000006384 203.0
TLS1_k127_1946662_2 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000007762 190.0
TLS1_k127_2013408_0 PFAM Glycoside hydrolase, family 38 K01191 - 3.2.1.24 2.035e-309 968.0
TLS1_k127_2013408_1 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 290.0
TLS1_k127_2013408_2 phosphoheptose isomerase K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000002857 257.0
TLS1_k127_2055462_0 Domain of unknown function (DUF4445) - - - 1.261e-271 854.0
TLS1_k127_2055462_1 Trimethylamine methyltransferase (MTTB) - - - 6.637e-241 754.0
TLS1_k127_2055462_10 Protein of unknown function (DUF1638) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000483 244.0
TLS1_k127_2055462_11 GMC oxidoreductase K00108 - 1.1.99.1 0.000000000000000000000000000000000000000000000000000000000006648 209.0
TLS1_k127_2055462_12 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000003436 164.0
TLS1_k127_2055462_13 transcriptional regulator - - - 0.0000000000000000000000000000000000000000006795 166.0
TLS1_k127_2055462_14 Virulence factor - - - 0.00000000000000000002452 102.0
TLS1_k127_2055462_15 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000001588 60.0
TLS1_k127_2055462_2 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005358 443.0
TLS1_k127_2055462_3 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008644 423.0
TLS1_k127_2055462_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 415.0
TLS1_k127_2055462_5 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 368.0
TLS1_k127_2055462_6 transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009422 375.0
TLS1_k127_2055462_7 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 334.0
TLS1_k127_2055462_8 Spermidine synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000236 302.0
TLS1_k127_2055462_9 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000108 262.0
TLS1_k127_2056035_0 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 387.0
TLS1_k127_2056035_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000005966 159.0
TLS1_k127_2056035_2 - - - - 0.000000244 63.0
TLS1_k127_2056035_3 heavy metal translocating P-type ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000009893 57.0
TLS1_k127_2061786_0 Acyl- CoA dehydrogenase type 2 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 557.0
TLS1_k127_2061786_1 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006586 396.0
TLS1_k127_2061786_10 O-methyltransferase - - - 0.00000000000000000000000009574 121.0
TLS1_k127_2061786_11 Protein of unknown function (DUF3224) - - - 0.000000000000000000000002726 108.0
TLS1_k127_2061786_12 AMP binding K06149 - - 0.0000000000000009872 88.0
TLS1_k127_2061786_13 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000003006 76.0
TLS1_k127_2061786_14 acetyltransferase - - - 0.000000000001381 80.0
TLS1_k127_2061786_15 Helix-turn-helix domain - - - 0.0000001081 63.0
TLS1_k127_2061786_16 Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role K09994 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019634,GO:0019637,GO:0033051,GO:0044237,GO:0044424,GO:0044464,GO:0071704,GO:1901564 - 0.000001304 60.0
TLS1_k127_2061786_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009979 392.0
TLS1_k127_2061786_3 PFAM Lipopolysaccharide kinase (Kdo WaaP) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000567 386.0
TLS1_k127_2061786_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 393.0
TLS1_k127_2061786_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001325 248.0
TLS1_k127_2061786_6 sequence-specific DNA binding K00567,K13529,K15051 - 2.1.1.63,3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000219 244.0
TLS1_k127_2061786_7 VIT family - - - 0.0000000000000000000000000000000000000000000001812 177.0
TLS1_k127_2061786_8 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000005111 142.0
TLS1_k127_2061786_9 lactoylglutathione lyase activity - - - 0.000000000000000000000000001836 120.0
TLS1_k127_2076216_0 NAD(P)-binding Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 471.0
TLS1_k127_2076216_1 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000001382 94.0
TLS1_k127_2076216_2 TadE-like protein - - - 0.0000000002393 72.0
TLS1_k127_2076216_3 Putative Flp pilus-assembly TadE/G-like - - - 0.000423 53.0
TLS1_k127_2076216_4 - - - - 0.000985 52.0
TLS1_k127_2108450_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 422.0
TLS1_k127_2108450_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001142 268.0
TLS1_k127_2108450_10 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000001664 104.0
TLS1_k127_2108450_11 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000008676 95.0
TLS1_k127_2108450_12 Ribosomal protein L30p/L7e K02907 - - 0.000000000000000805 80.0
TLS1_k127_2108450_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000001602 237.0
TLS1_k127_2108450_3 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000001049 230.0
TLS1_k127_2108450_4 Belongs to the universal ribosomal protein uS5 family K02988 - - 0.0000000000000000000000000000000000000000000000000000000000008115 220.0
TLS1_k127_2108450_5 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000001915 214.0
TLS1_k127_2108450_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000004745 169.0
TLS1_k127_2108450_7 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000003118 149.0
TLS1_k127_2108450_8 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000792 139.0
TLS1_k127_2108450_9 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000002521 102.0
TLS1_k127_2161900_0 Belongs to the glycosyl hydrolase 13 family - - - 6.412e-213 677.0
TLS1_k127_2161900_1 Family 4 glycosyl hydrolase K01222 - 3.2.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 544.0
TLS1_k127_2161900_2 N-acetylglucosamine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001085 280.0
TLS1_k127_2161900_3 DeoC/LacD family aldolase K01635,K01671 - 4.1.2.40,4.1.2.57 0.0000000000000000000000000000000000000000000000000000000007881 212.0
TLS1_k127_2164188_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 4.864e-238 746.0
TLS1_k127_2164188_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 347.0
TLS1_k127_2164188_2 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005377 267.0
TLS1_k127_2164188_3 Membrane - - - 0.000000000000000000415 93.0
TLS1_k127_2164188_4 - K01992 - - 0.000001591 61.0
TLS1_k127_2201259_0 acetolactate synthase K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 407.0
TLS1_k127_2201259_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000005547 221.0
TLS1_k127_2201259_2 YCII-related domain K09780 - - 0.0001466 52.0
TLS1_k127_2205876_0 Belongs to the glycosyl hydrolase 13 family - - - 4.798e-260 831.0
TLS1_k127_2205876_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005442 526.0
TLS1_k127_2205876_2 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007407 356.0
TLS1_k127_2205876_3 peptidase activity K01467,K06160 - 3.5.2.6 0.0000000000000000000000000000000000000000009629 172.0
TLS1_k127_2205876_4 Acyl-ACP thioesterase - - - 0.00005906 52.0
TLS1_k127_2218053_0 protein involved in exopolysaccharide biosynthesis - - - 2.421e-215 688.0
TLS1_k127_2218053_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 557.0
TLS1_k127_2218053_2 Xaa-Pro aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000755 519.0
TLS1_k127_2218053_3 PFAM oxidoreductase domain protein K13327 - 1.1.1.384 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 332.0
TLS1_k127_2218053_4 ROK family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005822 247.0
TLS1_k127_2218053_5 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003195 241.0
TLS1_k127_2220445_0 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 426.0
TLS1_k127_2220445_1 carbohydrate transport K02027,K17244 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 443.0
TLS1_k127_2220445_2 PFAM binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K10233,K15771,K17245 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007201 375.0
TLS1_k127_2220445_3 transmembrane transport K02025,K05814,K10118,K10237,K10241,K15771,K17235,K17242,K17316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 352.0
TLS1_k127_2220445_4 glycerophosphodiester transmembrane transport K17246 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 351.0
TLS1_k127_2220445_5 PFAM ROK family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 315.0
TLS1_k127_2220445_6 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000009998 231.0
TLS1_k127_2220445_7 BadF/BadG/BcrA/BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000001391 228.0
TLS1_k127_2220445_8 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000009611 220.0
TLS1_k127_2220445_9 Polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000009863 126.0
TLS1_k127_2252024_0 peptidase - - - 3.743e-196 659.0
TLS1_k127_2252024_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 548.0
TLS1_k127_2252024_10 COG1177 ABC-type spermidine putrescine transport system, permease component II K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005039 269.0
TLS1_k127_2252024_11 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000001914 232.0
TLS1_k127_2252024_12 ABC transporter, solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000007707 241.0
TLS1_k127_2252024_13 mannose-1-phosphate guanylyltransferase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000001078 199.0
TLS1_k127_2252024_14 D-glucuronyl C5-epimerase C-terminus - - - 0.0000000000000000000000000000000000000005282 171.0
TLS1_k127_2252024_15 Belongs to the EIF-2B alpha beta delta subunits family. MtnA subfamily K08963 - 5.3.1.23 0.000000000000000000000000000000000000009313 166.0
TLS1_k127_2252024_16 Cro/C1-type HTH DNA-binding domain - - - 0.00000000000000000000000000000000000005287 151.0
TLS1_k127_2252024_17 acetyltransferase - - - 0.00000000000000000002177 106.0
TLS1_k127_2252024_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 546.0
TLS1_k127_2252024_3 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 455.0
TLS1_k127_2252024_4 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009927 444.0
TLS1_k127_2252024_5 PFAM binding-protein-dependent transport systems inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 456.0
TLS1_k127_2252024_6 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 424.0
TLS1_k127_2252024_7 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 370.0
TLS1_k127_2252024_8 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009729 323.0
TLS1_k127_2252024_9 Binding-protein-dependent transport system inner membrane component K11071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008674 287.0
TLS1_k127_2277183_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008982 577.0
TLS1_k127_2277183_1 Glycosyl transferases group 1 K08256 - 2.4.1.345 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001284 294.0
TLS1_k127_2277183_2 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000002623 158.0
TLS1_k127_2277183_3 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.0000000000000000000000000000005514 144.0
TLS1_k127_2277183_4 Bacterial lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.00000000000000001729 97.0
TLS1_k127_2277183_5 PFAM lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.00000000000000003814 93.0
TLS1_k127_230773_0 Subtilase family - - - 0.0 1236.0
TLS1_k127_230773_1 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003941 559.0
TLS1_k127_230773_10 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001064 255.0
TLS1_k127_230773_11 endonuclease III K03575 - - 0.000000000000000000000000000000000000000000000000000000005076 216.0
TLS1_k127_230773_12 Male sterility protein K00091,K19997 - 1.1.1.219,5.1.3.26 0.000000000000000000000000000000000000000000000001057 189.0
TLS1_k127_230773_13 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000007287 135.0
TLS1_k127_230773_14 Probable zinc-ribbon domain - - - 0.000000000000000000000000000009714 128.0
TLS1_k127_230773_15 cobalt transport K16785 - - 0.0000000000000000000000002399 119.0
TLS1_k127_230773_16 - - - - 0.000000000002035 70.0
TLS1_k127_230773_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 460.0
TLS1_k127_230773_3 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 444.0
TLS1_k127_230773_4 Dehydrogenase E1 component K00166 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 381.0
TLS1_k127_230773_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 372.0
TLS1_k127_230773_6 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007586 311.0
TLS1_k127_230773_7 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627,K09699 - 2.3.1.12,2.3.1.168 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 323.0
TLS1_k127_230773_8 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006977 265.0
TLS1_k127_230773_9 part of an ABC transporter complex. Responsible for energy coupling to the transport system K16785,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007098 257.0
TLS1_k127_2328392_0 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003103 519.0
TLS1_k127_2328392_1 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 442.0
TLS1_k127_2328392_2 Protein of unknown function (DUF4446) - - - 0.000000000000000000000001775 110.0
TLS1_k127_2328392_3 protein methyltransferase activity - - - 0.0000000000000000006343 87.0
TLS1_k127_2362304_0 Belongs to the thiolase family K00626,K02615 - 2.3.1.174,2.3.1.223,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 546.0
TLS1_k127_2362304_1 ATP dependent DNA ligase C terminal region K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005462 438.0
TLS1_k127_2362304_10 PFAM binding-protein-dependent transport systems inner membrane component K05846 - - 0.000000000000000000000000000000000000000000000000000000003802 207.0
TLS1_k127_2362304_11 F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000005166 204.0
TLS1_k127_2362304_12 PFAM phenylacetic acid catabolic family protein K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000005549 207.0
TLS1_k127_2362304_13 Glycine betaine K05845 - - 0.00000000000000000000000000000000000000000000000000005307 200.0
TLS1_k127_2362304_14 TAP-like protein - - - 0.000000000000000000000000000000000000000000000004271 179.0
TLS1_k127_2362304_15 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000003892 167.0
TLS1_k127_2362304_16 Phenylacetate-CoA oxygenase K02612 - - 0.00000000000000000000000000000000000000006884 159.0
TLS1_k127_2362304_17 PFAM peptidase S16 lon domain protein K01338,K07157 - 3.4.21.53 0.00000000000000000000000000000000001035 149.0
TLS1_k127_2362304_18 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000001658 141.0
TLS1_k127_2362304_19 Acetyltransferase (GNAT) domain K03824,K09964 - - 0.0000000000000000000000000000000008188 138.0
TLS1_k127_2362304_2 TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 430.0
TLS1_k127_2362304_20 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000000007057 132.0
TLS1_k127_2362304_21 Cupin domain - - - 0.0000000000000000000000003301 113.0
TLS1_k127_2362304_22 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000002897 108.0
TLS1_k127_2362304_23 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000001199 104.0
TLS1_k127_2362304_24 phenylacetate catabolic process K02610 - - 0.0000000000000000002804 93.0
TLS1_k127_2362304_3 ATPases associated with a variety of cellular activities K05847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 392.0
TLS1_k127_2362304_4 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006248 341.0
TLS1_k127_2362304_5 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001886 286.0
TLS1_k127_2362304_6 PFAM oxidoreductase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005866 276.0
TLS1_k127_2362304_7 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000007025 265.0
TLS1_k127_2362304_8 ABC transporter (Permease) K05846 - - 0.00000000000000000000000000000000000000000000000000000000002457 223.0
TLS1_k127_2362304_9 L11 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000008023 211.0
TLS1_k127_2369137_0 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 321.0
TLS1_k127_2369137_1 Beta-ketoacyl synthase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 336.0
TLS1_k127_2369137_2 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001419 234.0
TLS1_k127_2369137_3 Conserved hypothetical protein (DUF2461) - - - 0.00000000000000000000000000000000000000000003594 176.0
TLS1_k127_2369137_4 PFAM NUDIX hydrolase - - - 0.0000000000000000000000000000000001355 136.0
TLS1_k127_2369137_5 negative regulation of translational initiation K05554,K15885 - - 0.0000000000000005422 89.0
TLS1_k127_2382075_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 7.286e-204 652.0
TLS1_k127_2382075_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009062 588.0
TLS1_k127_2382075_10 zinc metalloprotease K04771,K11749,K16922 GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0040007,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 3.4.21.107 0.00000000000000000000000000000000000000000000000000000001291 221.0
TLS1_k127_2382075_11 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000003391 205.0
TLS1_k127_2382075_12 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000002101 191.0
TLS1_k127_2382075_13 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000004641 164.0
TLS1_k127_2382075_14 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000297 150.0
TLS1_k127_2382075_15 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000002457 160.0
TLS1_k127_2382075_16 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000007069 117.0
TLS1_k127_2382075_17 Protein of unknown function (DUF448) K07742 - - 0.00000000000000000138 91.0
TLS1_k127_2382075_18 Belongs to the UPF0102 family K07460 - - 0.0000000001762 68.0
TLS1_k127_2382075_2 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 376.0
TLS1_k127_2382075_3 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 340.0
TLS1_k127_2382075_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 321.0
TLS1_k127_2382075_5 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 303.0
TLS1_k127_2382075_6 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000001869 260.0
TLS1_k127_2382075_7 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000001537 256.0
TLS1_k127_2382075_8 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.0000000000000000000000000000000000000000000000000000000000000000005355 234.0
TLS1_k127_2382075_9 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000004996 219.0
TLS1_k127_2436074_0 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 322.0
TLS1_k127_2436074_1 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000009729 260.0
TLS1_k127_2436074_10 ABC transporter - - - 0.0000000000000000000598 98.0
TLS1_k127_2436074_11 BetI-type transcriptional repressor, C-terminal - - - 0.0000000000004256 79.0
TLS1_k127_2436074_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000001039 224.0
TLS1_k127_2436074_3 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000001003 207.0
TLS1_k127_2436074_4 LysE type translocator - - - 0.00000000000000000000000000000000000000000000001133 180.0
TLS1_k127_2436074_5 ABC transporter - - - 0.0000000000000000000000000000000000000005471 168.0
TLS1_k127_2436074_6 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.000000000000000000000000000006182 128.0
TLS1_k127_2436074_7 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.000000000000000000000000006912 124.0
TLS1_k127_2436074_8 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000000000000002416 119.0
TLS1_k127_2436074_9 TIGRFAM Diguanylate cyclase - - - 0.000000000000000000000003729 106.0
TLS1_k127_2440743_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 4.24e-285 889.0
TLS1_k127_2440743_1 HAD-hyrolase-like K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000006173 226.0
TLS1_k127_2440743_2 NUBPL iron-transfer P-loop NTPase K02282 - - 0.000000000000000000004968 106.0
TLS1_k127_244130_0 Belongs to the aldehyde dehydrogenase family K22187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 467.0
TLS1_k127_244130_1 MMPL family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 475.0
TLS1_k127_244130_2 Galactose oxidase, central domain - - - 0.0000000000000000000000000000000000000000000000000004508 197.0
TLS1_k127_244130_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000004143 90.0
TLS1_k127_244130_4 Hep Hag repeat protein K21449 - - 0.0000000003799 67.0
TLS1_k127_2558603_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 506.0
TLS1_k127_2558603_1 aminotransferase class I and II K00812,K10907,K14260,K14267 - 2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 470.0
TLS1_k127_2558603_10 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.00000000000000000000000000000000000000000000000000000000000000502 232.0
TLS1_k127_2558603_11 ABC-type Na efflux pump, permease K01992 - - 0.00000000000000000000000000000000000000000000000000000000005393 220.0
TLS1_k127_2558603_12 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000004137 197.0
TLS1_k127_2558603_13 PFAM Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000002628 210.0
TLS1_k127_2558603_14 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000000127 158.0
TLS1_k127_2558603_15 Cupin - - - 0.0000000000000000004014 92.0
TLS1_k127_2558603_16 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000001371 93.0
TLS1_k127_2558603_17 ABC-2 family transporter protein K01992 - - 0.000000004789 69.0
TLS1_k127_2558603_18 Ecdysteroid kinase - - - 0.0000005028 61.0
TLS1_k127_2558603_2 PFAM peptidase S15 K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 469.0
TLS1_k127_2558603_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 393.0
TLS1_k127_2558603_4 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 388.0
TLS1_k127_2558603_5 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K02033,K12369 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 364.0
TLS1_k127_2558603_6 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 367.0
TLS1_k127_2558603_7 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 345.0
TLS1_k127_2558603_8 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 324.0
TLS1_k127_2558603_9 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000004554 264.0
TLS1_k127_2589049_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004167 520.0
TLS1_k127_2589049_1 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008546 383.0
TLS1_k127_2589049_2 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000002087 231.0
TLS1_k127_2589049_3 helix_turn_helix isocitrate lyase regulation - - - 0.0000000000000000000000000000000000000000000000000000002674 204.0
TLS1_k127_2589049_4 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.00000000000000000000000000000000003591 153.0
TLS1_k127_2589049_5 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000002002 136.0
TLS1_k127_2589049_6 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000005502 109.0
TLS1_k127_2594604_0 Tripartite tricarboxylate transporter TctA family K07793 - - 4.961e-242 756.0
TLS1_k127_2594604_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 1.073e-225 717.0
TLS1_k127_2594604_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K03737 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 626.0
TLS1_k127_2594604_3 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008693 430.0
TLS1_k127_2594604_4 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000000000000000000000436 160.0
TLS1_k127_2594604_5 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000036 157.0
TLS1_k127_2594604_6 CBS domain - - - 0.00000000000000001271 98.0
TLS1_k127_2594604_7 RDD family - - - 0.0000000000000004813 92.0
TLS1_k127_2594604_8 PFAM Flavodoxin K03809 - 1.6.5.2 0.0000000000001857 81.0
TLS1_k127_2635043_0 N-terminal domain of (some) glycogen debranching enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 576.0
TLS1_k127_2635043_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004927 512.0
TLS1_k127_2635043_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008203 366.0
TLS1_k127_2635043_3 Belongs to the N(4) N(6)-methyltransferase family K00571,K07319 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002109 270.0
TLS1_k127_2635043_4 Protein of unknown function (DUF1385) K09153 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002518 258.0
TLS1_k127_2635043_5 transferase K02851 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000003307 244.0
TLS1_k127_2635043_6 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000002054 182.0
TLS1_k127_2635043_7 Telomere recombination K07566 - 2.7.7.87 0.00000000000000000000000000000000000001995 152.0
TLS1_k127_2635043_8 TIGRFAM Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily - - - 0.00000000000000000000000000000000000002475 163.0
TLS1_k127_2730685_0 Type II/IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 381.0
TLS1_k127_2730685_1 PFAM response regulator receiver K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 349.0
TLS1_k127_2730685_2 histidine kinase, dimerisation and phosphoacceptor region K07777 - 2.7.13.3 0.000000000000000000000000000001521 134.0
TLS1_k127_2730685_3 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.0000002501 62.0
TLS1_k127_2730685_4 Flp/Fap pilin component K02651 - - 0.0004736 48.0
TLS1_k127_2730685_5 Flp/Fap pilin component K02651 - - 0.0006968 44.0
TLS1_k127_2730685_6 Flp Fap pilin component - - - 0.0008554 47.0
TLS1_k127_2755073_0 carbohydrate transport K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 419.0
TLS1_k127_2755073_1 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 363.0
TLS1_k127_2755073_2 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003736 278.0
TLS1_k127_2755073_3 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term K17108 - 3.2.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000001095 259.0
TLS1_k127_2808757_0 GMC oxidoreductase - - - 3.194e-241 778.0
TLS1_k127_2808757_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K05555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 456.0
TLS1_k127_2808757_2 Aldehyde dehydrogenase family K00141 - 1.2.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008788 434.0
TLS1_k127_2808757_3 Short-chain dehydrogenase reductase sdr K00046 - 1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 294.0
TLS1_k127_2808757_4 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000001281 252.0
TLS1_k127_2808757_5 Alanine racemase, C-terminal domain K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000001048 222.0
TLS1_k127_2808757_6 - - - - 0.000000000000001449 91.0
TLS1_k127_2832204_0 Penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 589.0
TLS1_k127_2832204_1 TIGRFAM FeS assembly protein SufD K09015 - - 0.0000000000000000000000000000000000000000000000000906 195.0
TLS1_k127_2832204_2 Ornithine cyclodeaminase mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000003221 139.0
TLS1_k127_2832204_3 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000146 93.0
TLS1_k127_2832204_4 Rieske [2Fe-2S] domain K18087 - - 0.00000000000003386 77.0
TLS1_k127_2832204_5 Fe-S cluster assembly protein SufB K07033,K09014 - - 0.0000000000002624 69.0
TLS1_k127_2836594_0 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000275 611.0
TLS1_k127_2836594_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 607.0
TLS1_k127_2836594_10 cellulase activity - - - 0.0000000000000000005648 102.0
TLS1_k127_2836594_11 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000876 83.0
TLS1_k127_2836594_12 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 0.000000000114 71.0
TLS1_k127_2836594_2 Bacterial protein of unknown function (DUF853) K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 511.0
TLS1_k127_2836594_3 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000586 426.0
TLS1_k127_2836594_4 Succinyl-CoA ligase like flavodoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 380.0
TLS1_k127_2836594_5 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 327.0
TLS1_k127_2836594_6 Alginate lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005421 307.0
TLS1_k127_2836594_7 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000669 229.0
TLS1_k127_2836594_8 amino acid-binding ACT domain protein K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000001313 220.0
TLS1_k127_2836594_9 PFAM Cobyrinic acid a,c-diamide synthase - - - 0.0000000000000000000000000000000000899 145.0
TLS1_k127_2867198_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000614 627.0
TLS1_k127_2867198_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 534.0
TLS1_k127_2867198_10 EamA-like transporter family - - - 0.0000000000000000000116 103.0
TLS1_k127_2867198_11 DinB superfamily - - - 0.0000000000000000005233 96.0
TLS1_k127_2867198_12 - - - - 0.00000000000001229 75.0
TLS1_k127_2867198_13 Flavin containing amine oxidoreductase - - - 0.000000000104 68.0
TLS1_k127_2867198_14 extracellular nuclease K07004 - - 0.000003236 61.0
TLS1_k127_2867198_15 - - - - 0.0000926 49.0
TLS1_k127_2867198_2 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 475.0
TLS1_k127_2867198_3 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000003915 239.0
TLS1_k127_2867198_4 Uridine phosphorylase K00757 - 2.4.2.3 0.000000000000000000000000000000000000000000000000000000000000001707 227.0
TLS1_k127_2867198_5 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000005867 148.0
TLS1_k127_2867198_6 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000001139 122.0
TLS1_k127_2867198_7 metal-binding protein - - - 0.000000000000000000000000001321 124.0
TLS1_k127_2867198_8 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000001231 123.0
TLS1_k127_2867198_9 impB/mucB/samB family K14161 - - 0.0000000000000000000000005201 119.0
TLS1_k127_28811_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 3135.0
TLS1_k127_28811_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 3.578e-229 721.0
TLS1_k127_28811_2 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005284 334.0
TLS1_k127_28811_3 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000008688 176.0
TLS1_k127_28811_4 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000009045 144.0
TLS1_k127_28811_5 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0001157 47.0
TLS1_k127_2912898_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 473.0
TLS1_k127_2912898_1 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 311.0
TLS1_k127_2912898_2 NAD binding domain of 6-phosphogluconate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003278 306.0
TLS1_k127_2912898_3 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 304.0
TLS1_k127_2912898_4 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000002541 125.0
TLS1_k127_3022773_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006924 548.0
TLS1_k127_3022773_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 421.0
TLS1_k127_3022773_2 peptidase K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 319.0
TLS1_k127_3022773_3 DRTGG domain K06873 - - 0.000000000000000000000000000000000000000000000000000000000000000001286 245.0
TLS1_k127_3022773_4 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000004874 192.0
TLS1_k127_3022773_5 TIGRFAM degV family protein - - - 0.000000000000000000000000000000000000003484 168.0
TLS1_k127_3022773_6 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000003786 136.0
TLS1_k127_3022773_7 Branched-chain amino acid permease - - - 0.000000000000000000000000002305 122.0
TLS1_k127_3022773_8 Domain of unknown function (DUF4349) - - - 0.000000000000000008542 92.0
TLS1_k127_3059005_0 Metallo-beta-lactamase superfamily - - - 8.122e-239 752.0
TLS1_k127_3059005_1 Belongs to the glycosyl hydrolase 31 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 540.0
TLS1_k127_3059005_10 ROK family - - - 0.00000000000000000000000000000000000000000006548 166.0
TLS1_k127_3059005_11 Bacterial transcription activator, effector binding domain - - - 0.0000000000000000000000000000003883 132.0
TLS1_k127_3059005_12 Ferric uptake regulator family K03711 - - 0.000000000000000000000000002173 117.0
TLS1_k127_3059005_13 membrane - - - 0.0000000007604 69.0
TLS1_k127_3059005_15 Limonene-1,2-epoxide hydrolase catalytic domain K06893 - - 0.00003235 56.0
TLS1_k127_3059005_2 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 385.0
TLS1_k127_3059005_3 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009391 378.0
TLS1_k127_3059005_4 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 334.0
TLS1_k127_3059005_5 F420-dependent oxidoreductase, MSMEG_2906 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 319.0
TLS1_k127_3059005_6 ABC 3 transport family K09819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009863 271.0
TLS1_k127_3059005_7 ATPases associated with a variety of cellular activities K09820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004011 255.0
TLS1_k127_3059005_8 methylglyoxal synthase activity K01734 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 0.0000000000000000000000000000000000000000000000000000000000000004429 223.0
TLS1_k127_3059005_9 Belongs to the bacterial solute-binding protein 9 family K09818 - - 0.00000000000000000000000000000000000000000000000000000001687 211.0
TLS1_k127_3131522_0 xanthine dehydrogenase activity - - - 8.789e-205 665.0
TLS1_k127_3131522_1 Pfam:Transaldolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 529.0
TLS1_k127_3131522_10 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000005863 214.0
TLS1_k127_3131522_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000003812 201.0
TLS1_k127_3131522_12 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000001295 191.0
TLS1_k127_3131522_13 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.000000000000000000000000000000000000000000000004804 183.0
TLS1_k127_3131522_14 Transcriptional regulator - - - 0.000000000000000000000000000000005695 140.0
TLS1_k127_3131522_15 - - - - 0.000000000000000000000000001658 116.0
TLS1_k127_3131522_16 Protein of unknown function (DUF3788) - - - 0.000000000000002734 87.0
TLS1_k127_3131522_17 Glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.0000000002147 66.0
TLS1_k127_3131522_18 - - - - 0.00000001261 67.0
TLS1_k127_3131522_19 diguanylate cyclase - - - 0.000005127 57.0
TLS1_k127_3131522_2 N-acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 418.0
TLS1_k127_3131522_3 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 370.0
TLS1_k127_3131522_4 Amidohydrolase family K01487 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 298.0
TLS1_k127_3131522_5 transport systems K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001673 258.0
TLS1_k127_3131522_6 Belongs to the malate synthase family K01638 - 2.3.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000008279 246.0
TLS1_k127_3131522_7 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000002787 253.0
TLS1_k127_3131522_8 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000147 255.0
TLS1_k127_3131522_9 xylulokinase activity K00848,K00851,K00854,K00862 - 2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5 0.00000000000000000000000000000000000000000000000000000000000000004407 249.0
TLS1_k127_3142995_0 Elongation factor G, domain IV K18220 - - 5.192e-196 631.0
TLS1_k127_3142995_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 382.0
TLS1_k127_3142995_2 Dihydrofolate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 285.0
TLS1_k127_3142995_4 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000000000000000000000000000001378 226.0
TLS1_k127_3142995_5 Belongs to the UPF0246 family K09861 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 - 0.000000000000000000000000000000000000000000000000000006049 210.0
TLS1_k127_3142995_6 pyridoxamine 5'-phosphate K07005 - - 0.000000000000000000000000000000000001564 145.0
TLS1_k127_3142995_7 Protein conserved in bacteria - - - 0.000000000000000000000004627 106.0
TLS1_k127_3142995_8 - - - - 0.00000000000000000000001273 103.0
TLS1_k127_3151868_0 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 5.855e-196 649.0
TLS1_k127_3151868_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 576.0
TLS1_k127_3151868_10 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000004616 173.0
TLS1_k127_3151868_11 Bacterial-like globin K06886 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000002034 155.0
TLS1_k127_3151868_12 dehydratase - - - 0.0000000000000000000000000000000000000002371 157.0
TLS1_k127_3151868_13 Cyclic-di-AMP receptor - - - 0.00000000000000000000000000000001355 133.0
TLS1_k127_3151868_14 Double zinc ribbon - - - 0.0000000000000000000000003552 113.0
TLS1_k127_3151868_15 HD domain - - - 0.000000000000000000002654 107.0
TLS1_k127_3151868_16 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000429 98.0
TLS1_k127_3151868_17 CAAX protease self-immunity K07052 - - 0.0001046 55.0
TLS1_k127_3151868_18 Anti-sigma-K factor rskA - - - 0.0004 53.0
TLS1_k127_3151868_2 Cell division protein FtsA K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 449.0
TLS1_k127_3151868_3 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 393.0
TLS1_k127_3151868_4 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008101 383.0
TLS1_k127_3151868_5 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 333.0
TLS1_k127_3151868_6 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000003213 233.0
TLS1_k127_3151868_7 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000001025 210.0
TLS1_k127_3151868_8 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000006131 195.0
TLS1_k127_3151868_9 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000001609 166.0
TLS1_k127_3207323_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1289.0
TLS1_k127_3207323_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.017e-283 894.0
TLS1_k127_3207323_10 TadE-like protein - - - 0.00000001611 66.0
TLS1_k127_3207323_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 620.0
TLS1_k127_3207323_3 PFAM ABC transporter related K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 387.0
TLS1_k127_3207323_4 Belongs to the pyruvate kinase family K00873 GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009784 357.0
TLS1_k127_3207323_5 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009532 250.0
TLS1_k127_3207323_6 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000001935 242.0
TLS1_k127_3207323_7 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000008215 171.0
TLS1_k127_3207323_8 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000001785 107.0
TLS1_k127_3207323_9 SAF K02279 - - 0.000000003534 68.0
TLS1_k127_3228082_0 Evidence 5 No homology to any previously reported sequences - - - 3.776e-265 848.0
TLS1_k127_3228082_1 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 1.985e-240 756.0
TLS1_k127_3228082_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 3.327e-208 657.0
TLS1_k127_3228082_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 306.0
TLS1_k127_3228082_4 PFAM regulatory protein GntR HTH K22293 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001354 272.0
TLS1_k127_3228082_5 Psort location Cytoplasmic, score K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000008486 192.0
TLS1_k127_3228082_6 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.00000000000000000000000000000000000000000000005514 186.0
TLS1_k127_3228082_7 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000005876 185.0
TLS1_k127_3238495_0 Carbamoyl-phosphate synthetase large chain domain protein K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 520.0
TLS1_k127_3238495_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 462.0
TLS1_k127_3238495_10 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000001666 128.0
TLS1_k127_3238495_11 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.00000000000000000000000008786 124.0
TLS1_k127_3238495_12 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000009678 94.0
TLS1_k127_3238495_13 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.00000005361 62.0
TLS1_k127_3238495_2 aspartate kinase activity K00928,K12524 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 437.0
TLS1_k127_3238495_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 312.0
TLS1_k127_3238495_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 296.0
TLS1_k127_3238495_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000005791 241.0
TLS1_k127_3238495_6 phosphinothricin N-acetyltransferase activity K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000002924 193.0
TLS1_k127_3238495_7 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000002204 162.0
TLS1_k127_3238495_8 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000002176 135.0
TLS1_k127_3238495_9 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.00000000000000000000000000001101 136.0
TLS1_k127_3256686_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 1.836e-283 902.0
TLS1_k127_3256686_1 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 467.0
TLS1_k127_3256686_2 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 314.0
TLS1_k127_3256686_3 hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000004406 221.0
TLS1_k127_3256686_4 domain, Protein - - - 0.0000000000000000000000000000000000000000001173 179.0
TLS1_k127_3256686_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000003078 127.0
TLS1_k127_3256686_6 Copper resistance protein K07156 - - 0.000001976 58.0
TLS1_k127_3285265_0 Flavin containing amine oxidoreductase - - - 4.078e-259 807.0
TLS1_k127_3285265_1 Type II/IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009835 542.0
TLS1_k127_3285265_2 carbohydrate transport K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 492.0
TLS1_k127_3285265_3 PFAM ABC transporter related K10112 GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264,GO:1901505 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005275 422.0
TLS1_k127_3285265_4 Metal-independent alpha-mannosidase (GH125) K09704 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007471 322.0
TLS1_k127_3285265_5 PFAM Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007939 308.0
TLS1_k127_3285265_6 glycerophosphodiester transmembrane transport K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 315.0
TLS1_k127_3396_0 PFAM glycoside hydrolase, family 3 domain protein K05349 - 3.2.1.21 9.371e-224 728.0
TLS1_k127_3396_1 ABC-type sugar transport system, ATPase component K10441 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 611.0
TLS1_k127_3396_10 ABC-type sugar transport system, permease component K02026,K10119,K17243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 325.0
TLS1_k127_3396_11 Branched-chain amino acid transport system / permease component K10440 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 322.0
TLS1_k127_3396_12 protein containing SIS (Sugar isomerase) phosphosugar binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 301.0
TLS1_k127_3396_13 DeoC/LacD family aldolase K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001024 284.0
TLS1_k127_3396_14 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000002207 249.0
TLS1_k127_3396_15 PFAM ROK family protein K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000001699 229.0
TLS1_k127_3396_16 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000232 207.0
TLS1_k127_3396_17 UTRA K03710 - - 0.0000000000000000000000000000000000000000000000006397 190.0
TLS1_k127_3396_18 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000001456 181.0
TLS1_k127_3396_19 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.000000000000000000002239 97.0
TLS1_k127_3396_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 588.0
TLS1_k127_3396_3 AP endonuclease family 2 C terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 474.0
TLS1_k127_3396_4 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 467.0
TLS1_k127_3396_5 Periplasmic binding protein LacI transcriptional regulator K17640 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 420.0
TLS1_k127_3396_6 Bacterial extracellular solute-binding protein K10117 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 418.0
TLS1_k127_3396_7 Binding-protein-dependent transport system inner membrane component K02025,K10118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 357.0
TLS1_k127_3396_8 Periplasmic binding protein domain K02058,K10439,K17213 GO:0003674,GO:0005215,GO:0005488,GO:0005534,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015144,GO:0015145,GO:0015749,GO:0015757,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 346.0
TLS1_k127_3396_9 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000959 343.0
TLS1_k127_3410230_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 491.0
TLS1_k127_3410230_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 310.0
TLS1_k127_3410230_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001917 276.0
TLS1_k127_3410230_3 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000001542 224.0
TLS1_k127_3410230_4 aminopeptidase N - - - 0.0000000000000000000000000000000000000001465 173.0
TLS1_k127_3410230_5 aminopeptidase N - - - 0.000000000000000000000000000000000001069 160.0
TLS1_k127_3410230_6 adenylate kinase activity K00939 - 2.7.4.3 0.000000000000000000000006866 106.0
TLS1_k127_3410230_7 Peptidase family M23 K21471 - - 0.000000000000000000007836 107.0
TLS1_k127_3410230_8 peptidase A24A prepilin type IV K02654 - 3.4.23.43 0.000000000001802 76.0
TLS1_k127_3410230_9 Transcriptional regulator K07110 - - 0.0001486 52.0
TLS1_k127_3410983_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 5.676e-293 921.0
TLS1_k127_3410983_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 411.0
TLS1_k127_3410983_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 298.0
TLS1_k127_3410983_3 Thioesterase superfamily - - - 0.000000000000000000000000000006323 126.0
TLS1_k127_3410983_4 DNA alkylation repair - - - 0.000000001409 70.0
TLS1_k127_3410983_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000001407 53.0
TLS1_k127_3471781_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009629 475.0
TLS1_k127_3471781_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 406.0
TLS1_k127_3471781_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 387.0
TLS1_k127_3471781_3 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 369.0
TLS1_k127_3471781_4 regulation of RNA biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003504 263.0
TLS1_k127_3471781_5 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000003381 186.0
TLS1_k127_3471781_6 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000000000000000001035 138.0
TLS1_k127_3471781_7 Transcriptional regulator - - - 0.0000000000000000000000000002796 120.0
TLS1_k127_3471781_8 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000005018 78.0
TLS1_k127_3471781_9 Protein of unknown function (DUF2905) - - - 0.000000000000002055 78.0
TLS1_k127_3597951_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 6.423e-200 639.0
TLS1_k127_3597951_1 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 446.0
TLS1_k127_3597951_10 Binding-protein-dependent transport system inner membrane component K10007 - - 0.0000000000000000000000000000000000001768 161.0
TLS1_k127_3597951_11 Glucose-6-phosphate dehydrogenase subunit - - - 0.00000000000000000000000000000000001307 152.0
TLS1_k127_3597951_12 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000000002671 152.0
TLS1_k127_3597951_13 membrane - - - 0.00000000002378 66.0
TLS1_k127_3597951_2 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 408.0
TLS1_k127_3597951_3 D-gluconate metabolic process K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 388.0
TLS1_k127_3597951_4 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 342.0
TLS1_k127_3597951_5 PFAM ABC transporter related K02028 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 329.0
TLS1_k127_3597951_6 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007276 316.0
TLS1_k127_3597951_7 Belongs to the bacterial solute-binding protein 3 family K09969,K10039 - - 0.000000000000000000000000000000000000000000000000000001905 203.0
TLS1_k127_3597951_8 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000002016 204.0
TLS1_k127_3597951_9 Binding-protein-dependent transport system inner membrane component K10040 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000005388 154.0
TLS1_k127_3605748_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 3.395e-243 773.0
TLS1_k127_3605748_1 Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 387.0
TLS1_k127_3605748_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 368.0
TLS1_k127_3605748_3 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 327.0
TLS1_k127_3605748_4 PFAM Methicillin resistance protein - - - 0.0000000000000000000000000000000000000000000006356 182.0
TLS1_k127_3605748_5 FemAB family K05363,K11693 - 2.3.2.10,2.3.2.16 0.0000000000000001158 94.0
TLS1_k127_3635136_0 DNA alkylation repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001257 251.0
TLS1_k127_3635136_2 CAAX protease self-immunity - - - 0.0000000000001212 81.0
TLS1_k127_3635136_3 Transcriptional regulator - - - 0.00000001402 57.0
TLS1_k127_3635136_4 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.00000002276 67.0
TLS1_k127_3661521_0 Ser Thr phosphatase family protein - - - 2.37e-204 704.0
TLS1_k127_3661521_1 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000385 277.0
TLS1_k127_3661521_2 Sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000004128 208.0
TLS1_k127_3661521_3 Domain of unknown function (DUF1735) - - - 0.00000000007222 78.0
TLS1_k127_367421_0 Endoribonuclease that initiates mRNA decay K18682 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 470.0
TLS1_k127_367421_1 Ami_3 K01448 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000001147 216.0
TLS1_k127_367421_2 - - - - 0.00000000000000000000000000000000000000000000000000000000002421 214.0
TLS1_k127_367421_3 Modulates RecA activity K03565 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000002747 84.0
TLS1_k127_3824622_0 Aminotransferase, class I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 458.0
TLS1_k127_3824622_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 406.0
TLS1_k127_3824622_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001573 267.0
TLS1_k127_3824622_3 Abc transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000001137 226.0
TLS1_k127_3824622_4 periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000002326 199.0
TLS1_k127_3824622_5 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000131 142.0
TLS1_k127_3824622_6 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000000000000003535 141.0
TLS1_k127_3824622_7 Belongs to the arginase family K01476 - 3.5.3.1 0.0000000000000000000000000001056 134.0
TLS1_k127_3824622_8 PFAM zinc finger, SWIM domain protein - - - 0.0000000000000000000000003319 109.0
TLS1_k127_3824622_9 Mannose-1-phosphate guanylyltransferase K00971 - 2.7.7.13 0.000003212 54.0
TLS1_k127_3837492_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 1.826e-201 647.0
TLS1_k127_3837492_1 Proline racemase K01777,K12658 - 5.1.1.4,5.1.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 516.0
TLS1_k127_3837492_10 serine-type endopeptidase activity K04771 GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000001671 239.0
TLS1_k127_3837492_11 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000005702 237.0
TLS1_k127_3837492_12 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000004579 216.0
TLS1_k127_3837492_13 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000000005316 193.0
TLS1_k127_3837492_14 (Rhomboid) family - - - 0.00000000000000000000000000000000000000000000000000009635 214.0
TLS1_k127_3837492_15 menaquinone-dependent protoporphyrinogen oxidase activity K00230 - 1.3.5.3 0.000000000000000000000000000000000000000000000004736 180.0
TLS1_k127_3837492_16 Belongs to the urease gamma subunit family K14048 - 3.5.1.5 0.000000000000000000000000000000000000000000007847 170.0
TLS1_k127_3837492_17 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000002179 159.0
TLS1_k127_3837492_18 DUF218 domain - - - 0.000000000000000000000000000000000000001903 157.0
TLS1_k127_3837492_19 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.000000000000000000000000000000004573 139.0
TLS1_k127_3837492_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007935 489.0
TLS1_k127_3837492_20 VanW like protein - - - 0.0000000000000000000000000000002306 141.0
TLS1_k127_3837492_21 regulation of RNA biosynthetic process - - - 0.00000000000000000000000000001099 125.0
TLS1_k127_3837492_22 Thioredoxin - - - 0.00000000000000000000000000008959 126.0
TLS1_k127_3837492_23 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000002479 130.0
TLS1_k127_3837492_24 PFAM single-stranded nucleic acid binding R3H domain protein K06346 - - 0.000000000000000000000000003765 129.0
TLS1_k127_3837492_25 integral membrane protein K00728 - 2.4.1.109 0.000000000000000000000006868 116.0
TLS1_k127_3837492_26 60Kd inner membrane protein K03217 - - 0.00000000000000000000009854 113.0
TLS1_k127_3837492_27 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000001099 107.0
TLS1_k127_3837492_28 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000004446 97.0
TLS1_k127_3837492_29 PFAM Vitamin K epoxide reductase - - - 0.00000000000001432 80.0
TLS1_k127_3837492_3 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 484.0
TLS1_k127_3837492_30 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000004047 76.0
TLS1_k127_3837492_31 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000001505 67.0
TLS1_k127_3837492_32 Acetyltransferase (GNAT) domain - - - 0.000000004486 67.0
TLS1_k127_3837492_33 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00004694 57.0
TLS1_k127_3837492_34 - - - - 0.00007967 53.0
TLS1_k127_3837492_4 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 376.0
TLS1_k127_3837492_5 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 351.0
TLS1_k127_3837492_6 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008528 334.0
TLS1_k127_3837492_7 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 313.0
TLS1_k127_3837492_8 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009403 294.0
TLS1_k127_3837492_9 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006518 269.0
TLS1_k127_3846699_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008986 313.0
TLS1_k127_3846699_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000006223 230.0
TLS1_k127_3846699_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000004109 218.0
TLS1_k127_3846699_3 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000001275 218.0
TLS1_k127_3846699_4 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000001094 135.0
TLS1_k127_3846699_5 Protein of unknown function (DUF1290) - - - 0.000000000000000000000000002473 114.0
TLS1_k127_3846699_6 Belongs to the SEDS family K02563,K03588 GO:0008150,GO:0040007 2.4.1.227 0.0000000000003992 72.0
TLS1_k127_3846699_7 Cell division protein FtsQ K03589 - - 0.00000001736 67.0
TLS1_k127_3850842_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 392.0
TLS1_k127_3850842_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 349.0
TLS1_k127_3850842_10 PFAM PfkB domain protein - - - 0.000000000000000005071 95.0
TLS1_k127_3850842_11 Xylose isomerase-like TIM barrel - - - 0.0000000000000007232 91.0
TLS1_k127_3850842_12 - - - - 0.000000000000001553 83.0
TLS1_k127_3850842_13 - - - - 0.0000000117 63.0
TLS1_k127_3850842_2 Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) K00010 - 1.1.1.18,1.1.1.369 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003994 309.0
TLS1_k127_3850842_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003322 273.0
TLS1_k127_3850842_4 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004807 274.0
TLS1_k127_3850842_5 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000003121 243.0
TLS1_k127_3850842_6 permease K02025 - - 0.000000000000000000000000000000000000000000000000000000000002153 220.0
TLS1_k127_3850842_7 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000006957 218.0
TLS1_k127_3850842_8 Xylose isomerase-like TIM barrel K00010,K03335 - 1.1.1.18,1.1.1.369,4.2.1.44 0.000000000000000000000000000000000000000000000000000645 198.0
TLS1_k127_3850842_9 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000009071 158.0
TLS1_k127_3885268_0 TPM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002048 261.0
TLS1_k127_3885268_1 PspA/IM30 family K03969 - - 0.000000000000000000000000000000000000000000000000000000000000000159 239.0
TLS1_k127_3885268_2 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000006015 218.0
TLS1_k127_3885268_3 DNA methylase K00590 - 2.1.1.113 0.000000000000000000000000000000000000000000000000000002089 209.0
TLS1_k127_3885268_4 Histidine kinase - - - 0.000000000000000000000000000000000000000000000001201 196.0
TLS1_k127_3885268_5 Sporulation and spore germination - - - 0.00000000000000000000000000001612 130.0
TLS1_k127_3885421_0 Tripartite tricarboxylate transporter TctA family K07793 - - 5.816e-249 786.0
TLS1_k127_3885421_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 2.79e-202 653.0
TLS1_k127_3885421_10 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000004907 210.0
TLS1_k127_3885421_11 Tripartite tricarboxylate transporter TctB family K07794 - - 0.000000000000000000000000000000000000005703 152.0
TLS1_k127_3885421_12 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000005248 147.0
TLS1_k127_3885421_13 Phosphate acyltransferases - - - 0.000000000000000652 88.0
TLS1_k127_3885421_14 An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor - - - 0.0004016 49.0
TLS1_k127_3885421_2 Pyridoxal-phosphate dependent enzyme K01697 - 4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000056 491.0
TLS1_k127_3885421_3 signal transduction histidine kinase regulating citrate malate metabolism - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 452.0
TLS1_k127_3885421_4 Tripartite tricarboxylate transporter family receptor K07795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 404.0
TLS1_k127_3885421_5 Cys Met metabolism K01739,K01758,K01761 - 2.5.1.48,4.4.1.1,4.4.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 379.0
TLS1_k127_3885421_6 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 334.0
TLS1_k127_3885421_7 Belongs to the MenA family. Type 1 subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008477 328.0
TLS1_k127_3885421_8 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002294 273.0
TLS1_k127_3885421_9 cheY-homologous receiver domain K02475 - - 0.000000000000000000000000000000000000000000000000000000000000000000319 242.0
TLS1_k127_3903764_0 Glycosyltransferase 36 associated - - - 5.296e-271 875.0
TLS1_k127_3903764_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 5.026e-231 746.0
TLS1_k127_3903764_10 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 302.0
TLS1_k127_3903764_11 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 321.0
TLS1_k127_3903764_12 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001319 280.0
TLS1_k127_3903764_2 Elongation factor G C-terminus K06207 - - 2.206e-225 716.0
TLS1_k127_3903764_3 PFAM glycoside hydrolase family 39 K01198 - 3.2.1.37 1.388e-195 635.0
TLS1_k127_3903764_4 Protein of unknown function (DUF3131) - - - 1.062e-194 619.0
TLS1_k127_3903764_5 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 410.0
TLS1_k127_3903764_6 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 384.0
TLS1_k127_3903764_7 Binding-protein-dependent transport system inner membrane component K02025,K10118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 347.0
TLS1_k127_3903764_8 Binding-protein-dependent transport system inner membrane component K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 347.0
TLS1_k127_3903764_9 cell division - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000895 316.0
TLS1_k127_3960852_0 PFAM Pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 394.0
TLS1_k127_3960852_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009026 311.0
TLS1_k127_3960852_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009386 288.0
TLS1_k127_3960852_3 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K00177 - 1.2.7.1,1.2.7.3 0.00000000000000000000000000000000000000000000009239 175.0
TLS1_k127_3960852_4 4Fe-4S binding domain K00176 - 1.2.7.3 0.00000000000000001446 83.0
TLS1_k127_3960852_5 Domain of unknown function (DUF4872) - - - 0.0002702 53.0
TLS1_k127_3967771_0 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 518.0
TLS1_k127_3967771_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00016 - 1.1.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 415.0
TLS1_k127_3967771_2 epimerase dehydratase K01710,K01784 - 4.2.1.46,5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 377.0
TLS1_k127_3967771_3 NADH ubiquinone oxidoreductase 20 kDa subunit K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009796 301.0
TLS1_k127_3967771_4 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000003215 238.0
TLS1_k127_3967771_5 virulence factor MVIN family protein K03980 - - 0.0000000000000000000000000000009997 140.0
TLS1_k127_3967771_6 cyclic nucleotide binding K10914 - - 0.000000000000000000002981 109.0
TLS1_k127_3982346_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 320.0
TLS1_k127_3982346_1 glycosyl transferase group 1 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 321.0
TLS1_k127_3982346_10 Psort location Cytoplasmic, score 7.50 - - - 0.0008163 48.0
TLS1_k127_3982346_2 PFAM lipopolysaccharide biosynthesis protein K08253 - 2.7.10.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000225 290.0
TLS1_k127_3982346_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000003922 198.0
TLS1_k127_3982346_4 Protein of unknown function (DUF4012) - - - 0.0000000000000000000000000000005521 141.0
TLS1_k127_3982346_5 Protein of unknown function (DUF1232) - - - 0.00000000000000000000000003145 113.0
TLS1_k127_3982346_6 positive regulation of type IV pilus biogenesis K07343 - - 0.0000000000000001634 86.0
TLS1_k127_3982346_7 Domain of unknown function (DU1801) - - - 0.000000000004869 70.0
TLS1_k127_3982346_8 PFAM Sporulation and spore germination - - - 0.000006591 53.0
TLS1_k127_3982346_9 PFAM PKD domain containing protein - - - 0.00001286 55.0
TLS1_k127_4054076_0 Aldehyde oxidase and xanthine dehydrogenase a b hammerhead K03520,K11177 - 1.17.1.4,1.2.5.3 0.0 1235.0
TLS1_k127_4054076_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 324.0
TLS1_k127_4054076_2 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000001744 238.0
TLS1_k127_4054076_3 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000003268 237.0
TLS1_k127_4054076_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000001571 234.0
TLS1_k127_4054076_5 XdhC Rossmann domain - - - 0.00000000000000000000000000000000000000000000000000000000000001446 235.0
TLS1_k127_4054076_6 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000001177 162.0
TLS1_k127_4054076_7 oxidoreductase activity, acting on CH-OH group of donors K09386 - - 0.00000000000000000000000000000000035 149.0
TLS1_k127_4054076_8 translation initiation factor activity K06996 - - 0.000000000000000000003753 108.0
TLS1_k127_4118864_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 1.784e-195 640.0
TLS1_k127_4118864_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 614.0
TLS1_k127_4118864_2 PFAM FMN-dependent dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005712 298.0
TLS1_k127_4118864_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000575 154.0
TLS1_k127_4118864_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000001205 97.0
TLS1_k127_4118864_5 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.00001365 53.0
TLS1_k127_4194830_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1049.0
TLS1_k127_4194830_1 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 616.0
TLS1_k127_4194830_10 Transmembrane secretion effector K08225 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 311.0
TLS1_k127_4194830_11 CBS domain containing protein K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006954 308.0
TLS1_k127_4194830_12 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000002831 259.0
TLS1_k127_4194830_13 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003216 256.0
TLS1_k127_4194830_15 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000239 179.0
TLS1_k127_4194830_16 Histidine kinase K07642 - 2.7.13.3 0.000000000000000000000000000000114 127.0
TLS1_k127_4194830_17 Glyoxalase-like domain - - - 0.000000000000000000000000000008186 132.0
TLS1_k127_4194830_18 Oxidoreductase NAD-binding domain K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000005338 130.0
TLS1_k127_4194830_19 Arabinose efflux permease family protein - - - 0.000000000007118 78.0
TLS1_k127_4194830_2 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 542.0
TLS1_k127_4194830_20 - - - - 0.00000000001503 70.0
TLS1_k127_4194830_3 metallocarboxypeptidase activity K05996 - 3.4.17.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 541.0
TLS1_k127_4194830_4 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008058 474.0
TLS1_k127_4194830_5 Zn-dependent dipeptidase, microsomal dipeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 364.0
TLS1_k127_4194830_6 Alcohol dehydrogenase GroES-like domain K00121 - 1.1.1.1,1.1.1.284 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 356.0
TLS1_k127_4194830_7 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006696 324.0
TLS1_k127_4194830_8 FAD dependent oxidoreductase K00301 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 314.0
TLS1_k127_4194830_9 oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 305.0
TLS1_k127_4217889_0 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000004991 189.0
TLS1_k127_4217889_1 Cellulose biosynthesis protein BcsQ K02282 - - 0.00000000000000000000000000000000000000000000000009815 194.0
TLS1_k127_4217889_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576 - 0.000000000000000000000000004891 118.0
TLS1_k127_4217889_3 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963,K03111,K15125 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000005824 106.0
TLS1_k127_4217889_4 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000004274 96.0
TLS1_k127_4217889_5 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000002491 70.0
TLS1_k127_4236381_0 Subtilase family - - - 3.528e-196 633.0
TLS1_k127_4236381_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00113 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 424.0
TLS1_k127_4236381_2 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009377 303.0
TLS1_k127_4236381_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000001003 193.0
TLS1_k127_4236381_5 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000002137 121.0
TLS1_k127_4236381_7 Glycerol-3-phosphate dehydrogenase, anaerobic, B subunit K00112 - 1.1.5.3 0.00000000008223 66.0
TLS1_k127_4236381_8 - - - - 0.0004888 47.0
TLS1_k127_4264423_0 Major Facilitator Superfamily K18833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 464.0
TLS1_k127_4264423_1 Tetratricopeptide repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007979 416.0
TLS1_k127_4264423_2 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 389.0
TLS1_k127_4264423_3 involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005801 417.0
TLS1_k127_4264423_4 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 361.0
TLS1_k127_4264423_5 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000001948 228.0
TLS1_k127_4264423_6 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000000000000000000003226 194.0
TLS1_k127_4264423_7 PFAM Polyketide cyclase dehydrase and lipid transport - - - 0.0000000000007706 76.0
TLS1_k127_4264423_8 Polyketide cyclase / dehydrase and lipid transport - - - 0.0001175 47.0
TLS1_k127_4266100_0 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006475 364.0
TLS1_k127_4266100_1 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005282 305.0
TLS1_k127_4266100_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000005642 278.0
TLS1_k127_4266100_3 helix_turn_helix, Lux Regulon K02479 - - 0.000000000000000000000000000000000000000000000000000000000000001914 224.0
TLS1_k127_4266100_4 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000008059 190.0
TLS1_k127_4266100_5 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000001022 175.0
TLS1_k127_4266100_6 - - - - 0.0000000000000000000001169 112.0
TLS1_k127_4266100_7 - - - - 0.00000000000000178 83.0
TLS1_k127_4266100_8 TIGRFAM DNA binding domain - - - 0.00000000000006771 81.0
TLS1_k127_4266100_9 Heavy metal translocating P-type atpase - - - 0.0000001851 64.0
TLS1_k127_4268931_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 485.0
TLS1_k127_4268931_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 449.0
TLS1_k127_4268931_2 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 374.0
TLS1_k127_4268931_3 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007568 349.0
TLS1_k127_4268931_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000005122 237.0
TLS1_k127_4268931_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000009681 80.0
TLS1_k127_4279807_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 608.0
TLS1_k127_4279807_1 Penicillin-binding protein 2 K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 361.0
TLS1_k127_4279807_10 Binds the 23S rRNA K02909 - - 0.00000000000000000000000001551 110.0
TLS1_k127_4279807_11 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000002614 100.0
TLS1_k127_4279807_12 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000002692 75.0
TLS1_k127_4279807_13 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.0000002899 64.0
TLS1_k127_4279807_14 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.00005887 53.0
TLS1_k127_4279807_2 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 295.0
TLS1_k127_4279807_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005945 274.0
TLS1_k127_4279807_4 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009515 254.0
TLS1_k127_4279807_5 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000001486 190.0
TLS1_k127_4279807_6 Belongs to the N(4) N(6)-methyltransferase family K00571,K07319 - 2.1.1.72 0.000000000000000000000000000000000000000003963 156.0
TLS1_k127_4279807_7 Transcriptional regulator - - - 0.00000000000000000000000000000003229 132.0
TLS1_k127_4279807_8 arsR family - - - 0.00000000000000000000000000004053 119.0
TLS1_k127_4279807_9 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000335 122.0
TLS1_k127_4304135_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058,K16843 - 1.1.1.310,1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 505.0
TLS1_k127_4304135_1 Aminotransferase class-V K00436 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 351.0
TLS1_k127_4304135_2 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 312.0
TLS1_k127_4304135_3 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000005387 226.0
TLS1_k127_4304135_4 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000002362 166.0
TLS1_k127_4304135_5 Belongs to the phosphoglycerate mutase family K22305 - 3.1.3.3 0.00000000000000000005296 106.0
TLS1_k127_4305356_0 Lysine-2,3-aminomutase K01843 - 5.4.3.2 1.344e-217 690.0
TLS1_k127_4305356_1 PFAM MMPL domain protein K06994 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 629.0
TLS1_k127_4305356_2 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000547 378.0
TLS1_k127_4305356_3 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007219 276.0
TLS1_k127_4305356_4 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000001964 126.0
TLS1_k127_4305356_5 - - - - 0.00000000000000000000000009667 115.0
TLS1_k127_4329598_0 PFAM Amylo-alpha-16-glucosidase - - - 7.342e-205 660.0
TLS1_k127_4329598_1 typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000008593 171.0
TLS1_k127_4329598_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000001869 139.0
TLS1_k127_4329598_3 - - - - 0.0000001002 63.0
TLS1_k127_435522_0 Protein of unknown function, DUF255 K06888 - - 6.048e-209 681.0
TLS1_k127_435522_1 oxaloacetate decarboxylase activity K01572 - 4.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 531.0
TLS1_k127_435522_10 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000001763 141.0
TLS1_k127_435522_11 Carboxyl transferase domain - - - 0.0000000000000000000000002819 105.0
TLS1_k127_435522_12 Biotin-requiring enzyme - - - 0.0000000000000000000000003984 115.0
TLS1_k127_435522_13 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000005383 123.0
TLS1_k127_435522_14 PTS system fructose IIA component K05881 - 2.7.1.121 0.000000000000000000000002271 109.0
TLS1_k127_435522_15 sodium ion export across plasma membrane K01573 GO:0003674,GO:0003824,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008948,GO:0015672,GO:0016829,GO:0016830,GO:0016831,GO:0030001,GO:0051179,GO:0051234 4.1.1.3 0.00000000000000000000003446 104.0
TLS1_k127_435522_16 DoxX K16937 - 1.8.5.2 0.000000000000000000001076 105.0
TLS1_k127_435522_17 - K03649 - 3.2.2.28 0.0000000000000001841 87.0
TLS1_k127_435522_18 TIGRFAM Phosphotransferase System HPr (HPr) Family K11189 - - 0.000000000000003285 78.0
TLS1_k127_435522_19 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0005687 47.0
TLS1_k127_435522_2 PFAM Dak kinase K00863,K05878 - 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 473.0
TLS1_k127_435522_3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009041 355.0
TLS1_k127_435522_4 PFAM histone deacetylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 334.0
TLS1_k127_435522_5 Subtilase family K01342 - 3.4.21.62 0.0000000000000000000000000000000000000000000000000000000000000007134 250.0
TLS1_k127_435522_6 TIGRFAM dihydroxyacetone kinase, L subunit K05879 - 2.7.1.121 0.000000000000000000000000000000000000000000000000009006 190.0
TLS1_k127_435522_7 PFAM luciferase-like - - - 0.0000000000000000000000000000000000000000000000001899 188.0
TLS1_k127_435522_8 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000005637 173.0
TLS1_k127_435522_9 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000001031 142.0
TLS1_k127_4370028_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 603.0
TLS1_k127_4370028_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 370.0
TLS1_k127_4370028_10 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000004561 118.0
TLS1_k127_4370028_11 YbbR-like protein - - - 0.0000000000000000000000001103 121.0
TLS1_k127_4370028_12 Glycoprotease family K14742 GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.0000000000000000244 94.0
TLS1_k127_4370028_13 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000001346 87.0
TLS1_k127_4370028_14 MutL protein - - - 0.000000008908 68.0
TLS1_k127_4370028_15 Evidence 4 Homologs of previously reported genes of - - - 0.0002558 54.0
TLS1_k127_4370028_16 Tetratricopeptide repeat - - - 0.0006418 51.0
TLS1_k127_4370028_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 355.0
TLS1_k127_4370028_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000006778 258.0
TLS1_k127_4370028_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000002823 221.0
TLS1_k127_4370028_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000001856 213.0
TLS1_k127_4370028_6 DisA bacterial checkpoint controller nucleotide-binding K18672 GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 0.0000000000000000000000000000000000000000000000000000002465 206.0
TLS1_k127_4370028_7 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000006399 161.0
TLS1_k127_4370028_8 PFAM GDSL-like Lipase Acylhydrolase - - - 0.0000000000000000000000000000002586 141.0
TLS1_k127_4370028_9 PFAM Uncharacterised P-loop hydrolase UPF0079 K06925 - - 0.000000000000000000000000003704 124.0
TLS1_k127_438316_0 PFAM Helicase conserved C-terminal domain K06877 - - 3.237e-256 812.0
TLS1_k127_438316_1 Flotillin K07192 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001137 259.0
TLS1_k127_438316_2 Exonuclease K07502 - - 0.0000000000000000000000000000000000000000000345 180.0
TLS1_k127_438316_3 - - - - 0.000000001686 68.0
TLS1_k127_4389093_0 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006604 429.0
TLS1_k127_4389093_1 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000807 348.0
TLS1_k127_4389093_2 bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002904 282.0
TLS1_k127_4389093_3 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000009825 248.0
TLS1_k127_4389093_4 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000005491 213.0
TLS1_k127_4389093_5 Type VI secretion system effector, Hcp K11903 - - 0.0000000000000000000000000000000000000000000000000000000003934 206.0
TLS1_k127_4389093_6 Protein of unknown function (DUF1810) - - - 0.0000000000000000000000000000000000000000000000005028 180.0
TLS1_k127_4389093_7 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000000000000003257 156.0
TLS1_k127_4389093_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000001824 155.0
TLS1_k127_4389093_9 Aminotransferase class-III - - - 0.00000000000000000000000000000000004222 138.0
TLS1_k127_4391528_0 PFAM polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000355 447.0
TLS1_k127_4391528_1 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 398.0
TLS1_k127_4391528_10 Glycosyl transferases group 1 - - - 0.000000000000000009047 95.0
TLS1_k127_4391528_11 PFAM O-Antigen ligase - - - 0.00000000000000002325 96.0
TLS1_k127_4391528_12 Acetyltransferase (GNAT) domain - - - 0.000001365 59.0
TLS1_k127_4391528_13 Polysaccharide biosynthesis protein - - - 0.00008799 55.0
TLS1_k127_4391528_2 short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002322 282.0
TLS1_k127_4391528_3 PFAM Glycosyl transferase family 2 K16557 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000001157 258.0
TLS1_k127_4391528_4 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000005923 191.0
TLS1_k127_4391528_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000008418 169.0
TLS1_k127_4391528_6 Bacterial sugar transferase - - - 0.00000000000000000000000000000000001236 144.0
TLS1_k127_4391528_7 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000006662 130.0
TLS1_k127_4391528_8 Cell envelope-related transcriptional attenuator domain - - - 0.0000000000000000000000000000000148 143.0
TLS1_k127_4391528_9 TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family - - - 0.0000000000000000000000000001492 129.0
TLS1_k127_4456148_0 PFAM Amidohydrolase 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 344.0
TLS1_k127_4456148_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001508 282.0
TLS1_k127_4456148_10 Bacterial protein of unknown function (DUF881) - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000004039 98.0
TLS1_k127_4456148_11 Bacterial protein of unknown function (DUF951) - - - 0.000000000000000001491 88.0
TLS1_k127_4456148_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005161 286.0
TLS1_k127_4456148_3 SpoU rRNA Methylase family K03437 - - 0.00000000000000000000000000000000000000000000000000000000000000003594 239.0
TLS1_k127_4456148_4 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000007272 230.0
TLS1_k127_4456148_5 PFAM Asparaginase glutaminase K01424 - 3.5.1.1 0.000000000000000000000000000000000000000000000000000000001476 216.0
TLS1_k127_4456148_6 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.00000000000000000000000000000000000000000000000000001772 210.0
TLS1_k127_4456148_7 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000006843 162.0
TLS1_k127_4456148_8 Peptidase MA superfamily - - - 0.00000000000000000000000000000000000002517 164.0
TLS1_k127_4456148_9 Bacterial protein of unknown function (DUF881) - - - 0.0000000000000000000000001997 116.0
TLS1_k127_4476708_0 DNA primase, small subunit K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 595.0
TLS1_k127_4476708_1 belongs to the sigma-70 factor family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008807 470.0
TLS1_k127_4476708_2 - - - - 0.00000000000000000000000000000000000000545 147.0
TLS1_k127_4476708_3 YCII-related domain - - - 0.0000000000000000000000000000000000226 143.0
TLS1_k127_4476708_4 membrane - - - 0.000001096 54.0
TLS1_k127_4481810_0 purine-nucleoside phosphorylase activity K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 439.0
TLS1_k127_4481810_1 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005592 277.0
TLS1_k127_4481810_2 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000000000000000000000000000000000009827 228.0
TLS1_k127_4481810_3 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000002068 165.0
TLS1_k127_4481810_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000002014 149.0
TLS1_k127_4481810_5 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000006211 97.0
TLS1_k127_4481810_6 Phage shock protein C, PspC - - - 0.0003381 48.0
TLS1_k127_4489987_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 9.96e-240 753.0
TLS1_k127_4489987_1 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 471.0
TLS1_k127_4489987_10 LemA family K03744 - - 0.0000000000000000000000000006799 128.0
TLS1_k127_4489987_11 Pfam UbiA prenyltransferase - - - 0.0000000000000000000005513 106.0
TLS1_k127_4489987_12 PFAM Phospholipid glycerol acyltransferase - - - 0.000000000000000000005194 105.0
TLS1_k127_4489987_13 CoA-binding K09181 - - 0.000000000006684 73.0
TLS1_k127_4489987_14 Cold shock protein K03704 - - 0.00000000001876 72.0
TLS1_k127_4489987_15 Universal stress protein - - - 0.000000000122 74.0
TLS1_k127_4489987_16 - - - - 0.00005166 55.0
TLS1_k127_4489987_17 - - - - 0.0008417 51.0
TLS1_k127_4489987_2 Carbamoyl-phosphate synthetase large chain domain protein K01968 - 6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 447.0
TLS1_k127_4489987_3 Cellulose biosynthesis protein BcsQ K03496 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000006077 248.0
TLS1_k127_4489987_4 histidine kinase dimerisation and phosphoacceptor region K03406,K07673,K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000006157 257.0
TLS1_k127_4489987_5 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001347 239.0
TLS1_k127_4489987_6 Phosphoglycerate mutase family K02226 GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983 3.1.3.73 0.000000000000000000000000000000000000000000000000000000004028 220.0
TLS1_k127_4489987_7 His Kinase A (phosphoacceptor) domain K14982 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.000000000000000000000000000000000000000000000000001203 201.0
TLS1_k127_4489987_8 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000004882 190.0
TLS1_k127_4489987_9 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000002596 168.0
TLS1_k127_455370_0 Cell cycle protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009039 340.0
TLS1_k127_455370_1 ATPase associated with various cellular activities, AAA_5 K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 289.0
TLS1_k127_455370_2 penicillin-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002502 270.0
TLS1_k127_455370_3 PFAM Forkhead-associated protein - - - 0.00000000000000000000000000002954 127.0
TLS1_k127_455370_4 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000001795 102.0
TLS1_k127_455370_5 zinc finger - - - 0.0003295 51.0
TLS1_k127_4567300_0 AhpC/TSA family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 467.0
TLS1_k127_4567300_1 Cytochrome b K03891 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 449.0
TLS1_k127_4567300_2 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 371.0
TLS1_k127_4567300_3 Rieske [2Fe-2S] domain K03890 - - 0.000000000000000000000000000000000000000000000000000000000000007342 227.0
TLS1_k127_4567300_4 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000001097 188.0
TLS1_k127_4567300_5 cytochrome C K03889 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000002595 181.0
TLS1_k127_4567300_6 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000000000000002166 104.0
TLS1_k127_4567300_7 Oxidoreductase FAD-binding domain - - - 0.000006792 48.0
TLS1_k127_4618567_0 Lamin Tail Domain K07004 - - 2.075e-281 899.0
TLS1_k127_4618567_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 499.0
TLS1_k127_4618567_10 Glyoxalase-like domain K08234 - - 0.000008095 54.0
TLS1_k127_4618567_2 PFAM Formiminotransferase K00603,K01746 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001902 291.0
TLS1_k127_4618567_3 PFAM Amidohydrolase family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000006088 214.0
TLS1_k127_4618567_4 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000001837 172.0
TLS1_k127_4618567_5 MarR family - - - 0.0000000000000000000000000000000002656 137.0
TLS1_k127_4618567_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000001682 134.0
TLS1_k127_4618567_7 Belongs to the TPP enzyme family K01637,K01652 - 2.2.1.6,4.1.3.1 0.00000000000000003461 97.0
TLS1_k127_4618567_8 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000006153 75.0
TLS1_k127_4618567_9 Acetyltransferase (GNAT) family - - - 0.0000001006 63.0
TLS1_k127_4624284_0 Flavin containing amine oxidoreductase - - - 4.885e-241 762.0
TLS1_k127_4624284_1 decarboxylase K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 503.0
TLS1_k127_4624284_10 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000158 141.0
TLS1_k127_4624284_11 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000008386 138.0
TLS1_k127_4624284_12 Pfam:Pyridox_oxidase - - - 0.00000000000000000000000000001899 126.0
TLS1_k127_4624284_13 Psort location CytoplasmicMembrane, score - - - 0.000000000000000004542 97.0
TLS1_k127_4624284_14 Bacterial protein of unknown function (DUF937) - - - 0.00000000000009936 78.0
TLS1_k127_4624284_15 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0007654 48.0
TLS1_k127_4624284_2 TIGRFAM phytoene desaturase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 452.0
TLS1_k127_4624284_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008162 408.0
TLS1_k127_4624284_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 389.0
TLS1_k127_4624284_5 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007927 339.0
TLS1_k127_4624284_6 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 307.0
TLS1_k127_4624284_7 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000002607 258.0
TLS1_k127_4624284_8 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000001003 262.0
TLS1_k127_4624284_9 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000001317 229.0
TLS1_k127_4699245_0 Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007366 457.0
TLS1_k127_4699245_1 Domain of unknown function DUF11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 333.0
TLS1_k127_4699245_2 Zn peptidase - - - 0.000000000000000000000000000000000000000000000000000000112 213.0
TLS1_k127_4699245_3 - - - - 0.000000000000000000000000000000000000000000007916 190.0
TLS1_k127_4699245_4 domain protein - - - 0.00003701 54.0
TLS1_k127_470471_0 elongation factor G K02355 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 311.0
TLS1_k127_470471_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 326.0
TLS1_k127_470471_2 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000005008 253.0
TLS1_k127_470471_3 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000003089 219.0
TLS1_k127_470471_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000001371 214.0
TLS1_k127_470471_5 TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000131 188.0
TLS1_k127_470471_6 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000002533 180.0
TLS1_k127_470471_7 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000004464 115.0
TLS1_k127_470471_8 Trp repressor protein - - - 0.000000000000000000001594 101.0
TLS1_k127_4776796_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1105.0
TLS1_k127_4776796_1 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.000000000000006625 79.0
TLS1_k127_4776796_2 Cellulase (glycosyl hydrolase family 5) - - - 0.0001219 48.0
TLS1_k127_4875953_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 511.0
TLS1_k127_4875953_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 445.0
TLS1_k127_4875953_10 glyoxalase III activity - - - 0.000000005469 64.0
TLS1_k127_4875953_11 SatD family (SatD) - - - 0.00006177 53.0
TLS1_k127_4875953_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 311.0
TLS1_k127_4875953_3 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001155 282.0
TLS1_k127_4875953_4 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000003907 216.0
TLS1_k127_4875953_5 Dienelactone hydrolase - - - 0.0000000000000000000000000000000000008925 151.0
TLS1_k127_4875953_6 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000001096 101.0
TLS1_k127_4875953_7 Protein of unknown function (DUF3307) - - - 0.0000000000003299 82.0
TLS1_k127_4875953_8 cyclic nucleotide binding K10914 - - 0.00000000001045 73.0
TLS1_k127_4875953_9 aminotransferase class I and II K00812,K10907,K14260,K14267 - 2.6.1.1,2.6.1.17,2.6.1.2,2.6.1.66 0.0000000003412 61.0
TLS1_k127_4883736_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 407.0
TLS1_k127_4883736_1 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 394.0
TLS1_k127_4883736_10 BioY protein K03523 - - 0.0000000000000000000000000000000000000000000000004496 183.0
TLS1_k127_4883736_11 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.000000000000000000000000000000000002673 154.0
TLS1_k127_4883736_12 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000002953 135.0
TLS1_k127_4883736_13 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000001815 139.0
TLS1_k127_4883736_14 Peptidase family M1 domain - - - 0.00000000000000000000000001613 125.0
TLS1_k127_4883736_15 Endoribonuclease L-PSP - - - 0.000000000000000000001657 100.0
TLS1_k127_4883736_16 - - - - 0.00000000000000000007387 94.0
TLS1_k127_4883736_17 PFAM Cysteine-rich secretory protein family - - - 0.0000000000000000001025 102.0
TLS1_k127_4883736_2 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 332.0
TLS1_k127_4883736_3 Domain of unknown function (DUF4331) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 323.0
TLS1_k127_4883736_4 GCN5 family acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006961 269.0
TLS1_k127_4883736_5 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000297 267.0
TLS1_k127_4883736_6 Oxidoreductase NAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000101 258.0
TLS1_k127_4883736_7 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000196 255.0
TLS1_k127_4883736_8 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000002274 261.0
TLS1_k127_4883736_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000006283 233.0
TLS1_k127_492644_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 419.0
TLS1_k127_492644_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001531 253.0
TLS1_k127_492644_2 PFAM glycosyl transferase, family 51 - - - 0.000000000000000000000000000000000000000000000000000000000007013 233.0
TLS1_k127_492644_3 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000002052 188.0
TLS1_k127_5014404_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007774 477.0
TLS1_k127_5014404_1 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009419 399.0
TLS1_k127_5014404_2 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 365.0
TLS1_k127_5014404_3 pfam nudix - - - 0.0000000000000000000000005071 114.0
TLS1_k127_5014404_4 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000001981 118.0
TLS1_k127_5014404_5 GTP binding - - - 0.00000000000000002572 96.0
TLS1_k127_5014404_6 Cupin 2, conserved barrel domain protein K05916 - 1.14.12.17 0.00006775 53.0
TLS1_k127_5033825_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 2.391e-203 644.0
TLS1_k127_5033825_1 glutamine synthetase K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 594.0
TLS1_k127_5033825_2 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 307.0
TLS1_k127_5033825_3 ResB-like family K07399 - - 0.000000000000000000000000000000000000000000003407 182.0
TLS1_k127_5033825_4 AsnC family K03718 - - 0.00000000000000000000000000000000000000000004395 174.0
TLS1_k127_5033825_5 diguanylate cyclase - - - 0.0000000000000000000000000000000000000005268 165.0
TLS1_k127_5033825_6 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000001564 151.0
TLS1_k127_5033825_7 positive regulation of transcription, DNA-templated K09684 - - 0.000000000000005752 90.0
TLS1_k127_5120819_0 - - - - 0.000000000000000000000000000000000000000000000000000001903 203.0
TLS1_k127_5120819_1 Virulence activator alpha C-term - - - 0.00000000000000000000000000000000000000000006778 167.0
TLS1_k127_5120819_2 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000001614 130.0
TLS1_k127_5120819_3 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.00000000000003707 78.0
TLS1_k127_5120819_4 Belongs to the peptidase S8 family - - - 0.0000000006782 65.0
TLS1_k127_5120819_5 Belongs to the peptidase S8 family - - - 0.00003951 53.0
TLS1_k127_5126696_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.826e-212 688.0
TLS1_k127_5126696_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009364 501.0
TLS1_k127_5126696_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 322.0
TLS1_k127_5126696_3 PFAM AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005756 318.0
TLS1_k127_5126696_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.0000004463 52.0
TLS1_k127_5161983_0 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000006402 233.0
TLS1_k127_5161983_1 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.000000000000000000000000000000000000000000000001693 184.0
TLS1_k127_5161983_2 Lecithin:cholesterol acyltransferase - - - 0.0000000000000000000000000000000000000000003983 168.0
TLS1_k127_5161983_3 AAA domain - - - 0.0000000000000000003501 96.0
TLS1_k127_5161983_4 adenylate kinase activity - - - 0.000001045 55.0
TLS1_k127_5205395_0 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000000000000000000000000000007975 220.0
TLS1_k127_5205395_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000007873 96.0
TLS1_k127_5205395_2 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000008955 91.0
TLS1_k127_5205395_3 WD40-like Beta Propeller Repeat - - - 0.00000000002124 76.0
TLS1_k127_5207729_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 606.0
TLS1_k127_5207729_1 DEAD DEAH box helicase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 546.0
TLS1_k127_5207729_11 domain protein K03709 - - 0.00000000000000000000000000000004765 144.0
TLS1_k127_5207729_12 Molecular chaperone - - - 0.00000007936 64.0
TLS1_k127_5207729_13 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000001783 60.0
TLS1_k127_5207729_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 443.0
TLS1_k127_5207729_3 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 358.0
TLS1_k127_5207729_4 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 294.0
TLS1_k127_5207729_5 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000468 255.0
TLS1_k127_5207729_6 Cephalosporin hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000002824 215.0
TLS1_k127_5207729_7 cephalosporin hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000007822 217.0
TLS1_k127_5207729_8 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000002308 206.0
TLS1_k127_5207729_9 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000001511 187.0
TLS1_k127_5224918_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 451.0
TLS1_k127_5224918_1 Spermine spermidine synthase K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009553 297.0
TLS1_k127_5224918_10 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000001121 71.0
TLS1_k127_5224918_11 Glycosyltransferase family 87 K13671 GO:0000026,GO:0000030,GO:0003674,GO:0003824,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000001532 69.0
TLS1_k127_5224918_12 Glycosyltransferase family 87 - - - 0.00000001643 68.0
TLS1_k127_5224918_13 Glycosyltransferase family 87 K13671 GO:0000026,GO:0000030,GO:0003674,GO:0003824,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.00000007326 65.0
TLS1_k127_5224918_14 Glycosyltransferase family 87 - - - 0.0000001757 63.0
TLS1_k127_5224918_15 Glycosyltransferase family 87 - - - 0.000175 53.0
TLS1_k127_5224918_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001407 252.0
TLS1_k127_5224918_3 Pfam:DUF2029 - - - 0.0000000000000000000000000000000000000000000007679 183.0
TLS1_k127_5224918_4 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000002386 183.0
TLS1_k127_5224918_5 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000001573 152.0
TLS1_k127_5224918_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07777 - 2.7.13.3 0.00000000000000000000000000000000000125 161.0
TLS1_k127_5224918_7 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000006652 149.0
TLS1_k127_5224918_8 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000002097 135.0
TLS1_k127_5241975_0 Cys/Met metabolism PLP-dependent enzyme K00639 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 494.0
TLS1_k127_5241975_1 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 490.0
TLS1_k127_5241975_2 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - 0.0000000000000000000000000000000000000000000000000000000000007252 220.0
TLS1_k127_5241975_3 Beta-lactamase - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 - 0.0000000000000000000000000000003057 141.0
TLS1_k127_5241975_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000001499 128.0
TLS1_k127_5241975_5 zinc ion binding K04486 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15 0.000000000000000000000000000004077 132.0
TLS1_k127_5283536_0 peptidase U62, modulator of DNA gyrase K03568 - - 1.75e-215 682.0
TLS1_k127_5283536_1 peptidase U62, modulator of DNA gyrase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008144 400.0
TLS1_k127_5283536_2 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009413 310.0
TLS1_k127_5283536_3 COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001063 282.0
TLS1_k127_5283536_4 PFAM Haloacid dehalogenase domain protein hydrolase K01560,K07025 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000001193 234.0
TLS1_k127_5283536_5 Transcriptional regulator - - - 0.0000000000000000000000000000000000000004042 160.0
TLS1_k127_5283536_6 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000003005 122.0
TLS1_k127_5283536_7 transport system ATPase component K01990 - - 0.0000000000000000000000004595 111.0
TLS1_k127_5283536_8 Domain of unknown function (DU1801) - - - 0.00000000000000001489 87.0
TLS1_k127_5283536_9 - - - - 0.00000289 57.0
TLS1_k127_5311981_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 1.009e-252 811.0
TLS1_k127_5311981_1 AAA ATPase domain - - - 1.285e-246 793.0
TLS1_k127_5311981_10 PFAM Bacterial regulatory proteins, lacI family K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001831 273.0
TLS1_k127_5311981_11 GDP-mannose 4,6 dehydratase K21214 - - 0.00000000000000000000000000000000000000000000000000000000000002832 237.0
TLS1_k127_5311981_12 PFAM Methyltransferase type 12 - - - 0.00000000000000000000000000000000000000000000001571 179.0
TLS1_k127_5311981_13 - - - - 0.0000000000000000000000000000003467 139.0
TLS1_k127_5311981_14 regulatory protein, FmdB family - - - 0.000000001446 66.0
TLS1_k127_5311981_15 Glycosyl transferase - - - 0.00000001726 66.0
TLS1_k127_5311981_16 Virulence factor BrkB K07058 - - 0.000001385 61.0
TLS1_k127_5311981_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005179 583.0
TLS1_k127_5311981_3 SMART alpha amylase catalytic sub domain K01187 - 3.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 507.0
TLS1_k127_5311981_4 epimerase dehydratase K01710,K08678,K21211 - 4.1.1.35,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 451.0
TLS1_k127_5311981_5 PFAM Binding-protein-dependent transport system inner membrane component K02025,K10233 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 348.0
TLS1_k127_5311981_6 Nucleotidyl transferase K21210 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008018 351.0
TLS1_k127_5311981_7 ABC transporter substrate-binding protein K10232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 340.0
TLS1_k127_5311981_8 PFAM binding-protein-dependent transport systems inner membrane component K10234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 329.0
TLS1_k127_5311981_9 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008509 270.0
TLS1_k127_5346341_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 6.509e-273 863.0
TLS1_k127_5346341_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 2.827e-258 820.0
TLS1_k127_5346341_10 TrkA-C domain K03499 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000003298 209.0
TLS1_k127_5346341_11 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000001046 162.0
TLS1_k127_5346341_12 Cytidylate kinase-like family K00760 - 2.4.2.8 0.0000000000000000000000000000000000557 141.0
TLS1_k127_5346341_13 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000847 133.0
TLS1_k127_5346341_14 PFAM TrkA-N domain protein K03499 - - 0.000000000000000000000000000001895 136.0
TLS1_k127_5346341_15 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000001724 128.0
TLS1_k127_5346341_16 Transcriptional regulator K21600 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000732 101.0
TLS1_k127_5346341_17 helix_turn_helix, mercury resistance K13640 - - 0.00000000000000000003441 96.0
TLS1_k127_5346341_18 Universal stress protein family - - - 0.0000000000000000007233 96.0
TLS1_k127_5346341_2 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 503.0
TLS1_k127_5346341_3 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 335.0
TLS1_k127_5346341_4 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 332.0
TLS1_k127_5346341_5 PFAM ABC transporter related K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 320.0
TLS1_k127_5346341_6 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001193 282.0
TLS1_k127_5346341_7 Heat shock protein DnaJ domain protein K03686,K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000002631 245.0
TLS1_k127_5346341_8 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000001059 235.0
TLS1_k127_5346341_9 PFAM metallophosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000229 216.0
TLS1_k127_5348788_0 ketone body catabolic process K01026 - 2.8.3.1 1.015e-210 680.0
TLS1_k127_5348788_1 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000069 270.0
TLS1_k127_5348788_2 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000002558 259.0
TLS1_k127_5348788_3 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001516 258.0
TLS1_k127_5348788_4 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000003101 240.0
TLS1_k127_5348788_5 Belongs to the aldehyde dehydrogenase family K00141 - 1.2.1.28 0.000000000000000000000000000000000000000000000001049 176.0
TLS1_k127_5348788_6 Belongs to the DapA family K01714 - 4.3.3.7 0.0000000000000000000000000000000008707 149.0
TLS1_k127_5356554_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.0 1045.0
TLS1_k127_5356554_1 PFAM ABC transporter related K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 582.0
TLS1_k127_5356554_10 PFAM sigma-70 region 2 domain protein K03088 - - 0.0000000000000000000000000000000000002579 149.0
TLS1_k127_5356554_11 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000194 134.0
TLS1_k127_5356554_12 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000007056 130.0
TLS1_k127_5356554_13 CoA binding domain K01740,K06929 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.5.1.49 0.000000000000000000000000001735 129.0
TLS1_k127_5356554_14 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000001027 118.0
TLS1_k127_5356554_15 protein conserved in bacteria - - - 0.000000000000000003472 97.0
TLS1_k127_5356554_16 Protein of unknown function (DUF952) - - - 0.00000000000001871 89.0
TLS1_k127_5356554_17 - - - - 0.0000000004223 71.0
TLS1_k127_5356554_18 - - - - 0.000000007749 70.0
TLS1_k127_5356554_19 AntiSigma factor - - - 0.0004302 48.0
TLS1_k127_5356554_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 509.0
TLS1_k127_5356554_3 aminotransferase class I and II K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000074 481.0
TLS1_k127_5356554_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 484.0
TLS1_k127_5356554_5 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003138 277.0
TLS1_k127_5356554_6 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000007143 248.0
TLS1_k127_5356554_7 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000002071 211.0
TLS1_k127_5356554_8 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000005301 211.0
TLS1_k127_5356554_9 PFAM basic membrane lipoprotein K07335 - - 0.000000000000000000000000000000000000000000000000000001115 214.0
TLS1_k127_5402426_0 DEAD/H associated K03724 - - 0.0 1504.0
TLS1_k127_5402426_1 Peptidase family S51 K13282 - 3.4.15.6 0.000000000000000000000000000000000000000000000000000000000000000000000000001649 267.0
TLS1_k127_5402426_2 DoxX K16937 - 1.8.5.2 0.000000000000000000000000000000000000000000000000000000000000007481 224.0
TLS1_k127_5402426_3 Belongs to the FPG family K05522 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000001414 213.0
TLS1_k127_5402426_4 Belongs to the MurCDEF family K03802 - 6.3.2.29,6.3.2.30 0.000000000000000000000000000000000000000000000000006516 188.0
TLS1_k127_5402426_5 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000832 187.0
TLS1_k127_5402426_7 Glycosyltransferase family 87 - - - 0.000000006356 67.0
TLS1_k127_5402426_8 Glutamine amidotransferase domain - - - 0.0008695 50.0
TLS1_k127_542632_0 LPXTG-motif cell wall anchor domain - - - 9.275e-232 755.0
TLS1_k127_542632_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000001321 167.0
TLS1_k127_5456758_0 FAD dependent oxidoreductase central domain - - - 0.0 1167.0
TLS1_k127_5456758_1 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 3.374e-211 666.0
TLS1_k127_5456758_10 PFAM binding-protein-dependent transport systems inner membrane component K02053 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009151 285.0
TLS1_k127_5456758_11 Belongs to the BI1 family K06890 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000005242 179.0
TLS1_k127_5456758_12 HAD-hyrolase-like - - - 0.000000000000000000000000000000000000000006195 171.0
TLS1_k127_5456758_13 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000006501 149.0
TLS1_k127_5456758_14 Pfam:DUF59 - - - 0.00000000005973 70.0
TLS1_k127_5456758_2 Binding-protein-dependent transport system inner membrane component K02001 - - 1.029e-199 644.0
TLS1_k127_5456758_3 glycine betaine K02000 - 3.6.3.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 491.0
TLS1_k127_5456758_4 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 475.0
TLS1_k127_5456758_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 473.0
TLS1_k127_5456758_6 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 402.0
TLS1_k127_5456758_7 PFAM binding-protein-dependent transport systems inner membrane component K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 366.0
TLS1_k127_5456758_8 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 330.0
TLS1_k127_5456758_9 Electron transfer flavoprotein, beta subunit K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001316 280.0
TLS1_k127_554445_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 5.35e-219 695.0
TLS1_k127_554445_1 Cell division protein FtsA K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 450.0
TLS1_k127_554445_10 PHP-associated - - - 0.00000000000000000000000000000003157 136.0
TLS1_k127_554445_11 Transcriptional regulator - - - 0.00003055 53.0
TLS1_k127_554445_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 357.0
TLS1_k127_554445_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002968 276.0
TLS1_k127_554445_5 PFAM conserved K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000008158 243.0
TLS1_k127_554445_6 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000001196 211.0
TLS1_k127_554445_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000005219 135.0
TLS1_k127_554445_8 PFAM Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000001529 138.0
TLS1_k127_554445_9 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000000000000000000001139 134.0
TLS1_k127_5570367_0 RNase_H superfamily - - - 2.914e-293 939.0
TLS1_k127_5570367_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 411.0
TLS1_k127_5570367_10 hyperosmotic response K04065 - - 0.000000000000000001584 100.0
TLS1_k127_5570367_11 Acetylornithine deacetylase K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000256 74.0
TLS1_k127_5570367_12 Domain of unknown function (DUF1992) - - - 0.00000000001943 71.0
TLS1_k127_5570367_13 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - 0.0000001418 61.0
TLS1_k127_5570367_2 PFAM ABC transporter related K01990,K19340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002172 284.0
TLS1_k127_5570367_3 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000003756 253.0
TLS1_k127_5570367_4 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000001256 224.0
TLS1_k127_5570367_5 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.00000000000000000000000000000000000000000000000000000001209 213.0
TLS1_k127_5570367_6 Phosphatidylinositol - - - 0.000000000000000000000000000000000000000000000000000003873 193.0
TLS1_k127_5570367_7 - - - - 0.000000000000000000000001357 107.0
TLS1_k127_5570367_8 3-demethylubiquinone-9 3-O-methyltransferase activity K03428 - 2.1.1.11 0.000000000000000000000005196 116.0
TLS1_k127_5570367_9 amino acid transport - - - 0.00000000000000000002323 97.0
TLS1_k127_5573242_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004303 479.0
TLS1_k127_5573242_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 300.0
TLS1_k127_5573242_2 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000001723 234.0
TLS1_k127_5573242_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000008879 220.0
TLS1_k127_5573242_4 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000001172 189.0
TLS1_k127_5573242_5 cell division - - - 0.00000000000000000000002263 103.0
TLS1_k127_5573242_6 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000003932 89.0
TLS1_k127_5573242_7 Baseplate J-like protein K01218 - 3.2.1.78 0.0000000000005904 82.0
TLS1_k127_5573242_8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000001131 57.0
TLS1_k127_5573242_9 DinB superfamily - - - 0.000828 50.0
TLS1_k127_5627960_0 metallopeptidase activity K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004173 498.0
TLS1_k127_5627960_1 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 505.0
TLS1_k127_5627960_2 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003306 276.0
TLS1_k127_5627960_3 SnoaL-like polyketide cyclase K15945 - - 0.0000000000000000000000000000000000000000000000000000000004471 206.0
TLS1_k127_5627960_4 R3H domain - - - 0.00000000000000000000000000000000000000000003533 176.0
TLS1_k127_5627960_5 pyridoxamine 5-phosphate - - - 0.000000000000000000000000009484 114.0
TLS1_k127_563962_0 PFAM oxidoreductase molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 445.0
TLS1_k127_563962_1 family 4 K01222 - 3.2.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 425.0
TLS1_k127_563962_10 Protein of unknown function (DUF3090) - - - 0.000000000000000000000000000000000000000000001515 186.0
TLS1_k127_563962_11 family 4 K01222 - 3.2.1.86 0.000000000000000000008151 95.0
TLS1_k127_563962_2 carbohydrate transport K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 395.0
TLS1_k127_563962_3 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K05365 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006197 302.0
TLS1_k127_563962_4 Belongs to the UPF0271 (lamB) family K07160 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000464 269.0
TLS1_k127_563962_5 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000001355 252.0
TLS1_k127_563962_6 UbiC transcription regulator-associated domain protein K03710 - - 0.00000000000000000000000000000000000000000000000000000000000007644 222.0
TLS1_k127_563962_7 Allophanate hydrolase subunit 2 - - - 0.0000000000000000000000000000000000000000000000000000000000001517 224.0
TLS1_k127_563962_8 Phosphatidylinositol - - - 0.0000000000000000000000000000000000000000000000004746 186.0
TLS1_k127_563962_9 Allophanate hydrolase, subunit 1 - - - 0.0000000000000000000000000000000000000000000000008616 190.0
TLS1_k127_5697779_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004422 382.0
TLS1_k127_5697779_1 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 361.0
TLS1_k127_5697779_10 - - - - 0.0000000000001925 79.0
TLS1_k127_5697779_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 328.0
TLS1_k127_5697779_3 Protein tyrosine kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000572 184.0
TLS1_k127_5697779_4 transcriptional regulator - - - 0.000000000000000000000000000000000000000002928 160.0
TLS1_k127_5697779_5 PFAM Conserved TM helix repeat-containing protein - - - 0.0000000000000000000000000000000000139 145.0
TLS1_k127_5697779_6 - - - - 0.0000000000000000001653 89.0
TLS1_k127_5697779_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000001161 93.0
TLS1_k127_5697779_8 YCII-related domain - - - 0.000000000000000001979 91.0
TLS1_k127_5697779_9 amine dehydrogenase activity - - - 0.00000000000008176 85.0
TLS1_k127_5717728_0 helix_turn _helix lactose operon repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 365.0
TLS1_k127_5717728_1 Belongs to the glycosyl hydrolase family 6 K01179 - 3.2.1.4 0.0000000000000015 85.0
TLS1_k127_5717728_2 carbohydrate transport K02027 - - 0.000000000000004839 80.0
TLS1_k127_5719355_0 TrkA-N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 440.0
TLS1_k127_5719355_1 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 374.0
TLS1_k127_5719355_2 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001941 261.0
TLS1_k127_5719355_3 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000000000000000000000008221 157.0
TLS1_k127_5719355_4 PFAM MgtC SapB transporter K07507 - - 0.0000000000000000000000000000000000215 143.0
TLS1_k127_5719355_5 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000001069 71.0
TLS1_k127_5719355_6 COG2133 Glucose sorbosone dehydrogenases - - - 0.0005037 51.0
TLS1_k127_5738553_0 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 523.0
TLS1_k127_5738553_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 484.0
TLS1_k127_5738553_10 Mur ligase family, glutamate ligase domain K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000007772 171.0
TLS1_k127_5738553_11 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000003259 165.0
TLS1_k127_5738553_12 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000001143 144.0
TLS1_k127_5738553_13 integral membrane protein - - - 0.000000000000000000000000000000001542 141.0
TLS1_k127_5738553_14 - - - - 0.0000000000000000000000000000001114 136.0
TLS1_k127_5738553_15 regulation of RNA biosynthetic process - - - 0.000000000000000000000000002275 119.0
TLS1_k127_5738553_16 Histidine kinase - - - 0.0000000000000000000000002902 122.0
TLS1_k127_5738553_17 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000003659 107.0
TLS1_k127_5738553_18 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000000000702 109.0
TLS1_k127_5738553_19 PAS fold K14986 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.0004827 43.0
TLS1_k127_5738553_2 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000486 457.0
TLS1_k127_5738553_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 408.0
TLS1_k127_5738553_4 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 402.0
TLS1_k127_5738553_5 Exporter of polyketide antibiotics K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 393.0
TLS1_k127_5738553_6 FAD binding domain K14672,K15972 - 1.14.13.200 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007417 386.0
TLS1_k127_5738553_7 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007062 331.0
TLS1_k127_5738553_8 PFAM YibE F-like protein - - - 0.000000000000000000000000000000000000000000000000000000001216 216.0
TLS1_k127_5738553_9 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000949 209.0
TLS1_k127_5834519_0 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 383.0
TLS1_k127_5834519_1 GrpB protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008637 258.0
TLS1_k127_5834519_2 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000001856 183.0
TLS1_k127_5834519_3 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000005156 184.0
TLS1_k127_5834519_4 - - - - 0.00000000000000000000000000000000002157 139.0
TLS1_k127_5834519_5 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000866 70.0
TLS1_k127_5835970_0 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 393.0
TLS1_k127_5835970_1 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007195 337.0
TLS1_k127_5835970_2 amidohydrolase K21613 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001357 283.0
TLS1_k127_5835970_3 Zincin-like metallopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005231 260.0
TLS1_k127_5835970_4 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region - - - 0.000000000000000000000000000000000000000000000000000000000000003087 244.0
TLS1_k127_5835970_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000002636 223.0
TLS1_k127_5835970_6 PFAM response regulator receiver K02282 - - 0.000000000000000000000000000000000000003917 162.0
TLS1_k127_5835970_7 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000006119 138.0
TLS1_k127_5835970_8 HAD-hyrolase-like K20862 - 3.1.3.102,3.1.3.104 0.000000001545 70.0
TLS1_k127_5841961_0 Alpha amylase, catalytic domain - - - 3.106e-306 971.0
TLS1_k127_5841961_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 372.0
TLS1_k127_5841961_2 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 367.0
TLS1_k127_5841961_3 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 357.0
TLS1_k127_5841961_4 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 310.0
TLS1_k127_5841961_5 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000003745 250.0
TLS1_k127_5841961_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000001701 211.0
TLS1_k127_5841961_7 Belongs to the glycosyl hydrolase 57 family K22451 - 2.4.1.25 0.000000000000000000007222 103.0
TLS1_k127_5841961_8 membrane K08972 - - 0.000000000000000008536 91.0
TLS1_k127_5841961_9 helix_turn_helix gluconate operon transcriptional repressor - - - 0.00002914 55.0
TLS1_k127_5937252_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 376.0
TLS1_k127_5937252_1 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000001215 142.0
TLS1_k127_5937252_2 - - - - 0.00000000000003989 79.0
TLS1_k127_5937252_3 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000005399 74.0
TLS1_k127_5974918_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1154.0
TLS1_k127_5974918_1 ATPase P-type (Transporting), HAD superfamily, subfamily IC - - - 0.0 1052.0
TLS1_k127_5974918_10 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 315.0
TLS1_k127_5974918_11 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000635 267.0
TLS1_k127_5974918_12 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000002024 247.0
TLS1_k127_5974918_13 Uncharacterised protein family UPF0047 - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000001042 197.0
TLS1_k127_5974918_14 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000009328 203.0
TLS1_k127_5974918_15 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000008134 212.0
TLS1_k127_5974918_16 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000002102 170.0
TLS1_k127_5974918_17 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000002487 165.0
TLS1_k127_5974918_18 Rossmann-like domain - - - 0.00000000000000000000000000000000000006988 157.0
TLS1_k127_5974918_19 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000001778 143.0
TLS1_k127_5974918_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 602.0
TLS1_k127_5974918_20 NUDIX domain - - - 0.000000000000000000000000001735 122.0
TLS1_k127_5974918_21 YGGT family K02221 - - 0.00000000000009832 73.0
TLS1_k127_5974918_22 Belongs to the UPF0235 family K09131 - - 0.00000001018 59.0
TLS1_k127_5974918_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 421.0
TLS1_k127_5974918_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006068 405.0
TLS1_k127_5974918_5 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 396.0
TLS1_k127_5974918_6 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 396.0
TLS1_k127_5974918_7 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 400.0
TLS1_k127_5974918_8 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 394.0
TLS1_k127_5974918_9 ABC transporter substrate-binding protein K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004831 343.0
TLS1_k127_5980753_0 trimethylamine methyltransferase K14083 - 2.1.1.250 1.163e-208 690.0
TLS1_k127_5980753_1 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K15510 - 1.1.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 468.0
TLS1_k127_5980753_10 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 330.0
TLS1_k127_5980753_11 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 324.0
TLS1_k127_5980753_12 Ring hydroxylating alpha subunit (catalytic domain) K00479 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007818 330.0
TLS1_k127_5980753_13 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 297.0
TLS1_k127_5980753_14 PFAM Luciferase-like monooxygenase K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000002284 265.0
TLS1_k127_5980753_15 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005352 262.0
TLS1_k127_5980753_16 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000001322 257.0
TLS1_k127_5980753_17 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000007564 255.0
TLS1_k127_5980753_18 Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000735 235.0
TLS1_k127_5980753_19 ABC-type spermidine putrescine transport system, permease component II K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000004821 250.0
TLS1_k127_5980753_2 Belongs to the GcvT family K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 428.0
TLS1_k127_5980753_20 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000007837 220.0
TLS1_k127_5980753_21 Bacterial extracellular solute-binding protein K11069 - - 0.000000000000000000000000000000000000000000000000000000000003203 231.0
TLS1_k127_5980753_22 PFAM amino acid-binding ACT domain protein K06862 - - 0.000000000000000000000000000000000000000000000000000006561 199.0
TLS1_k127_5980753_23 Membrane protease subunits, stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000001896 189.0
TLS1_k127_5980753_24 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000001188 180.0
TLS1_k127_5980753_25 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.0000000000000000000000000000000000000000002895 170.0
TLS1_k127_5980753_26 Nickel-containing superoxide dismutase K00518 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 0.00000000000000000000000000000000000000001674 163.0
TLS1_k127_5980753_27 peptidase - - - 0.00000000000000000000000000000000002944 152.0
TLS1_k127_5980753_28 ArsC family - - - 0.0000000000000000000000000000000001227 137.0
TLS1_k127_5980753_29 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000004303 125.0
TLS1_k127_5980753_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 438.0
TLS1_k127_5980753_30 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000001467 68.0
TLS1_k127_5980753_31 Rieske-like [2Fe-2S] domain K05710 - - 0.000000001589 72.0
TLS1_k127_5980753_32 Peptidase S24-like K03100 - 3.4.21.89 0.00000001306 63.0
TLS1_k127_5980753_33 TPM domain K06872 - - 0.00000003913 66.0
TLS1_k127_5980753_34 Lysin motif - - - 0.00000004179 66.0
TLS1_k127_5980753_35 - - - - 0.0000008603 53.0
TLS1_k127_5980753_36 - - - - 0.000001125 61.0
TLS1_k127_5980753_37 SIS domain K00820 - 2.6.1.16 0.00003029 56.0
TLS1_k127_5980753_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 393.0
TLS1_k127_5980753_5 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 407.0
TLS1_k127_5980753_6 RNA-metabolising metallo-beta-lactamase K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 379.0
TLS1_k127_5980753_7 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 355.0
TLS1_k127_5980753_8 PFAM aspartate ornithine carbamoyltransferase, Asp Orn-binding region K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007822 355.0
TLS1_k127_5980753_9 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 352.0
TLS1_k127_5981457_0 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007783 331.0
TLS1_k127_5981457_1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 346.0
TLS1_k127_5981457_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000001144 291.0
TLS1_k127_5981457_3 Penicillin-binding Protein dimerisation domain K03587,K08384 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000002134 264.0
TLS1_k127_5981457_4 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.00000000000000000000000000000000005898 139.0
TLS1_k127_5981457_5 Lysin motif - - - 0.0001427 48.0
TLS1_k127_607430_0 PFAM major facilitator superfamily MFS_1 K08167 - - 3.942e-218 690.0
TLS1_k127_607430_1 PFAM carbohydrate kinase K00854 - 2.7.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 622.0
TLS1_k127_607430_10 PFAM CBS domain K07182 - - 0.000000000000000002833 90.0
TLS1_k127_607430_11 STAS domain - - - 0.0000000000401 68.0
TLS1_k127_607430_2 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 612.0
TLS1_k127_607430_3 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 576.0
TLS1_k127_607430_4 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 473.0
TLS1_k127_607430_5 Belongs to the binding-protein-dependent transport system permease family K10544 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 445.0
TLS1_k127_607430_6 ABC transporter K10545 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 361.0
TLS1_k127_607430_7 ABC transporter K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004807 322.0
TLS1_k127_607430_8 GyrI-like small molecule binding domain - - - 0.0000000000000000000000000000000001281 137.0
TLS1_k127_607430_9 ROK family - - - 0.000000000000000000006974 96.0
TLS1_k127_6084349_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 2.451e-288 904.0
TLS1_k127_6084349_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 301.0
TLS1_k127_6084349_2 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005611 253.0
TLS1_k127_6084349_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000008797 203.0
TLS1_k127_6084349_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000001721 151.0
TLS1_k127_6084349_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000004048 124.0
TLS1_k127_6084349_6 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.00000000000000001715 84.0
TLS1_k127_6084349_7 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000008812 59.0
TLS1_k127_6084349_8 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000496 55.0
TLS1_k127_6084856_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.379e-239 755.0
TLS1_k127_6084856_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 565.0
TLS1_k127_6084856_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 495.0
TLS1_k127_6084856_3 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 459.0
TLS1_k127_6084856_4 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000001744 224.0
TLS1_k127_6084856_5 Binds directly to 16S ribosomal RNA K02968 - - 0.000001525 60.0
TLS1_k127_6084856_6 EamA-like transporter family - - - 0.0004683 53.0
TLS1_k127_6205567_0 PFAM UvrD REP helicase K03657 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 509.0
TLS1_k127_6205567_1 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 370.0
TLS1_k127_6205567_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000002164 67.0
TLS1_k127_6205567_11 - - - - 0.000001723 55.0
TLS1_k127_6205567_12 Cysteine-rich secretory protein family - - - 0.0007766 51.0
TLS1_k127_6205567_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 344.0
TLS1_k127_6205567_4 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001436 261.0
TLS1_k127_6205567_5 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000004881 166.0
TLS1_k127_6205567_7 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000017 103.0
TLS1_k127_6205567_8 PFAM glycoside hydrolase, family 18 - - - 0.0000000000001357 84.0
TLS1_k127_6205567_9 Histidine kinase - - - 0.000000000004041 79.0
TLS1_k127_6205584_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 452.0
TLS1_k127_6205584_1 PFAM Acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 381.0
TLS1_k127_6205584_2 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007625 277.0
TLS1_k127_6205584_3 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002143 271.0
TLS1_k127_6205584_4 Dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000001461 263.0
TLS1_k127_6205584_5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000001797 267.0
TLS1_k127_6205584_6 histidine kinase A domain protein K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000002496 282.0
TLS1_k127_6205584_7 Belongs to the aldehyde dehydrogenase family K22187 - - 0.0000000000000000000000000000000000000000000000000000000000000000005112 237.0
TLS1_k127_6205584_8 Cobalamin B12-binding K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000003383 196.0
TLS1_k127_6205584_9 AraC-like ligand binding domain - - - 0.0001226 49.0
TLS1_k127_6263369_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 626.0
TLS1_k127_6263369_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000006909 187.0
TLS1_k127_6263369_2 SAM-dependent methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000007588 128.0
TLS1_k127_6263369_3 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.00008766 55.0
TLS1_k127_6281041_0 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000001394 252.0
TLS1_k127_6281041_1 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000002712 213.0
TLS1_k127_6281041_2 Serine hydrolase K07002 - - 0.000000000000000000000000000000000000000000000000000000002387 213.0
TLS1_k127_6281041_3 Belongs to the Pirin family K06911 - - 0.000000000000000000000000000000000000000000000000001328 192.0
TLS1_k127_6281041_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000001149 204.0
TLS1_k127_6281041_5 Belongs to the dihydrofolate reductase family - - - 0.000000000000000000000000000000000000000000004745 169.0
TLS1_k127_6281041_6 Acid phosphatase homologues - - - 0.00000000000000000000000000000000000000132 157.0
TLS1_k127_6281041_7 lipid kinase activity - - - 0.00000000000000000000000000000003471 141.0
TLS1_k127_6281041_8 ATP:ADP antiporter activity K15762 - - 0.00000000000004745 87.0
TLS1_k127_6281041_9 PFAM Cyclic nucleotide-binding - - - 0.00000000002653 78.0
TLS1_k127_6290694_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000801 580.0
TLS1_k127_6290694_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 357.0
TLS1_k127_6290694_2 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331,K22339 - 1.12.1.3,1.17.1.11,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 331.0
TLS1_k127_6290694_3 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 327.0
TLS1_k127_6290694_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005873 293.0
TLS1_k127_6290694_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000008844 198.0
TLS1_k127_6290694_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000517 116.0
TLS1_k127_6290694_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000005964 104.0
TLS1_k127_6290694_8 GTP binding - - - 0.00000000000009793 76.0
TLS1_k127_6290694_9 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.00000000002398 73.0
TLS1_k127_631236_0 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 506.0
TLS1_k127_631236_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 467.0
TLS1_k127_631236_2 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 354.0
TLS1_k127_631236_3 PFAM binding-protein-dependent transport systems inner membrane component K02053 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002148 293.0
TLS1_k127_631236_4 4Fe-4S binding domain - GO:0001666,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0009628,GO:0036293,GO:0043207,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0075136 - 0.000000000000000000000000001619 118.0
TLS1_k127_631236_5 Copper binding proteins, plastocyanin/azurin family - - - 0.000000008218 64.0
TLS1_k127_631236_6 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.000003356 49.0
TLS1_k127_6316768_0 PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.0 1042.0
TLS1_k127_6316768_1 PFAM Nickel-dependent hydrogenase, large subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 459.0
TLS1_k127_6316768_10 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000001536 220.0
TLS1_k127_6316768_11 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000007628 202.0
TLS1_k127_6316768_12 'Molybdopterin - - - 0.0000000000000000000000000000000000000000000000335 183.0
TLS1_k127_6316768_13 Rhomboid family K19225 - 3.4.21.105 0.000000000000000000000000112 121.0
TLS1_k127_6316768_14 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.0000000000000000000002404 112.0
TLS1_k127_6316768_15 Methyltransferase domain K07003 - - 0.00000000000000000001711 106.0
TLS1_k127_6316768_16 HupF/HypC family K04653 - - 0.000000000006347 68.0
TLS1_k127_6316768_17 Putative Flp pilus-assembly TadE/G-like - - - 0.000000006076 65.0
TLS1_k127_6316768_18 hydrogenase maturation protease - - - 0.0000003143 61.0
TLS1_k127_6316768_19 F420H(2)-dependent quinone reductase - - - 0.0000202 57.0
TLS1_k127_6316768_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006095 460.0
TLS1_k127_6316768_3 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 388.0
TLS1_k127_6316768_4 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 317.0
TLS1_k127_6316768_5 NADH ubiquinone oxidoreductase, 20 K18007 - 1.12.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000005384 282.0
TLS1_k127_6316768_6 XdhC and CoxI family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005265 273.0
TLS1_k127_6316768_7 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000001383 238.0
TLS1_k127_6316768_8 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000005275 237.0
TLS1_k127_6316768_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000007471 228.0
TLS1_k127_6317270_0 Molybdopterin oxidoreductase K00123 - 1.17.1.9 4.493e-241 756.0
TLS1_k127_6317270_1 amidohydrolase - - - 3.552e-194 625.0
TLS1_k127_6317270_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002288 231.0
TLS1_k127_6317270_11 Major facilitator Superfamily K08223 - - 0.00000000000000000000000000000000000000000000000000000000001329 224.0
TLS1_k127_6317270_12 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000006494 198.0
TLS1_k127_6317270_13 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000001215 203.0
TLS1_k127_6317270_14 Rieske-like [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000003595 192.0
TLS1_k127_6317270_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.00000000000000000000000000000000000000000003594 176.0
TLS1_k127_6317270_16 Domain of unknown function (DUF4397) - - - 0.00000000000000000000000000000000000000001767 164.0
TLS1_k127_6317270_17 Pfam:DUF2029 - - - 0.000000000000000000000000000000000000006841 153.0
TLS1_k127_6317270_18 Calcineurin-like phosphoesterase K03547 - - 0.000000000000000000000000000000004544 143.0
TLS1_k127_6317270_19 PFAM Metallophosphoesterase K01090 - 3.1.3.16 0.00000000000000000000000000000008285 130.0
TLS1_k127_6317270_2 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006418 518.0
TLS1_k127_6317270_20 Probable zinc-ribbon domain - - - 0.0000000000000000000000000001197 119.0
TLS1_k127_6317270_21 AAA domain - - - 0.0000000000000000000000002583 123.0
TLS1_k127_6317270_22 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0000000000000000000000003688 119.0
TLS1_k127_6317270_23 Belongs to the peptidase S51 family K13282 - 3.4.15.6 0.000000000000000000001984 109.0
TLS1_k127_6317270_24 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor - - - 0.000000000004469 78.0
TLS1_k127_6317270_25 Polyketide cyclase / dehydrase and lipid transport - - - 0.0001298 51.0
TLS1_k127_6317270_26 RDD family - - - 0.0001582 55.0
TLS1_k127_6317270_3 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 506.0
TLS1_k127_6317270_4 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 361.0
TLS1_k127_6317270_5 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 314.0
TLS1_k127_6317270_6 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000311 295.0
TLS1_k127_6317270_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00122,K00335 - 1.17.1.9,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005816 284.0
TLS1_k127_6317270_8 Glycosyl transferase, family 2 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009482 252.0
TLS1_k127_6317270_9 Methyltransferase small domain K00598 - 2.1.1.144 0.0000000000000000000000000000000000000000000000000000000000000000000197 241.0
TLS1_k127_6338300_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 4.666e-254 792.0
TLS1_k127_6338300_1 Dihydropyrimidinase K01464 - 3.5.2.2 8.184e-198 626.0
TLS1_k127_6338300_10 STAS domain K04749 - - 0.000000001312 64.0
TLS1_k127_6338300_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 367.0
TLS1_k127_6338300_3 Stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000001652 190.0
TLS1_k127_6338300_4 Bacterial transcriptional activator domain - - - 0.0000000000000000002828 98.0
TLS1_k127_6338300_5 SnoaL-like domain K06893 - - 0.0000000000000003851 83.0
TLS1_k127_6338300_6 Protein of unknown function (DUF2630) - - - 0.0000000000000142 78.0
TLS1_k127_6338300_7 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000006605 83.0
TLS1_k127_6338300_8 Histidine kinase-like ATPase domain - - - 0.0000000000001694 84.0
TLS1_k127_6338300_9 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.000000000001289 67.0
TLS1_k127_6342546_0 FtsX-like permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 418.0
TLS1_k127_6342546_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 371.0
TLS1_k127_6342546_10 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000165 203.0
TLS1_k127_6342546_11 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K00982,K03564 - 1.11.1.15,2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000003365 191.0
TLS1_k127_6342546_12 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000004166 189.0
TLS1_k127_6342546_13 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000001482 181.0
TLS1_k127_6342546_14 diguanylate cyclase - - - 0.0000000000000000000000000000000000001265 164.0
TLS1_k127_6342546_15 Polysaccharide deacetylase K22278 GO:0005575,GO:0016020 3.5.1.104 0.00000000000000000000000000000000001514 150.0
TLS1_k127_6342546_16 PFAM Thiamin pyrophosphokinase, catalytic region K00949 - 2.7.6.2 0.000000000000000000000000000000001447 139.0
TLS1_k127_6342546_17 PFAM glutamine amidotransferase class-I K07010 - - 0.00000000000000000000000000000001219 139.0
TLS1_k127_6342546_18 YbaK prolyl-tRNA synthetase associated region - - - 0.0000000000000000000000000000006795 128.0
TLS1_k127_6342546_19 subfamily IA, variant 1 K01091 - 3.1.3.18 0.0000000000000001326 93.0
TLS1_k127_6342546_2 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 370.0
TLS1_k127_6342546_20 Psort location Extracellular, score K21471 - - 0.000000000005162 76.0
TLS1_k127_6342546_3 ABC transporter, ATP-binding protein K02028,K02029 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 328.0
TLS1_k127_6342546_4 Binding-protein-dependent transport system inner membrane component K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 289.0
TLS1_k127_6342546_5 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005565 307.0
TLS1_k127_6342546_6 Bacterial periplasmic substrate-binding proteins K02030,K02424,K17073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002632 273.0
TLS1_k127_6342546_7 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002804 282.0
TLS1_k127_6342546_8 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000000000001957 246.0
TLS1_k127_6342546_9 WYL domain K07012,K13572 - - 0.0000000000000000000000000000000000000000000000000000000000000000003156 241.0
TLS1_k127_6345079_0 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 358.0
TLS1_k127_6345079_1 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001069 290.0
TLS1_k127_6345079_2 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000001337 229.0
TLS1_k127_6345079_3 GGDEF domain - - - 0.00000000000000000000000000000000000000001745 169.0
TLS1_k127_6345079_4 Ankyrin repeat - - - 0.0000000000000000000000000000007275 132.0
TLS1_k127_6345079_5 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000002965 136.0
TLS1_k127_6345079_6 Domain of unknown function (DUF378) K09779 - - 0.00000000106 62.0
TLS1_k127_6427098_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 368.0
TLS1_k127_6427098_1 ROK family K00845,K00886 - 2.7.1.2,2.7.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000005225 248.0
TLS1_k127_6447998_0 Fumarate reductase flavoprotein C-term K00239,K00278 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4,1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 598.0
TLS1_k127_6447998_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 340.0
TLS1_k127_6447998_2 Reverse transcriptase-like K02226,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.000000000000000000000000000002136 135.0
TLS1_k127_6447998_3 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 0.000000000000000001756 95.0
TLS1_k127_6447998_4 META domain - - - 0.0000009638 58.0
TLS1_k127_6474438_0 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 530.0
TLS1_k127_6474438_1 PFAM Acyl-CoA dehydrogenase K00248,K22430 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108,1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 391.0
TLS1_k127_6474438_2 Transcriptional regulator - - - 0.0000000000000000000000000000002057 132.0
TLS1_k127_6474438_3 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.00000000000000000000000002438 112.0
TLS1_k127_6541544_0 daunorubicin resistance ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 420.0
TLS1_k127_6541544_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 354.0
TLS1_k127_6541544_2 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001775 269.0
TLS1_k127_6541544_3 - - - - 0.0000000000000000000000000003684 115.0
TLS1_k127_6541544_4 negative regulation of translational initiation - - - 0.000000000000000000000001328 111.0
TLS1_k127_658880_0 Anticodon-binding domain of tRNA K01870 - 6.1.1.5 0.0 1097.0
TLS1_k127_658880_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 473.0
TLS1_k127_658880_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000001147 285.0
TLS1_k127_658880_3 cell envelope-related transcriptional attenuator - - - 0.000000000000000000000000000000000000000000000002238 193.0
TLS1_k127_658880_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000004657 162.0
TLS1_k127_658880_5 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000003655 104.0
TLS1_k127_6622499_0 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000001211 262.0
TLS1_k127_6622499_1 Glyco_18 K01448,K07260,K20276 - 3.4.17.14,3.5.1.28 0.0000000000000000000000000000000000001322 165.0
TLS1_k127_6622499_2 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000000000000000002297 164.0
TLS1_k127_6622499_3 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000001133 95.0
TLS1_k127_6647880_0 Belongs to the amidase family K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 470.0
TLS1_k127_6647880_1 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 446.0
TLS1_k127_6647880_10 - - - - 0.00000000000000000000000000000000001363 138.0
TLS1_k127_6647880_11 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000004785 134.0
TLS1_k127_6647880_12 PFAM DinB family protein - - - 0.000000000000000000000000009307 115.0
TLS1_k127_6647880_13 - - - - 0.0000000000000000000001134 106.0
TLS1_k127_6647880_14 Dodecin - - - 0.000000000000000000001855 95.0
TLS1_k127_6647880_15 GCN5-related N-acetyl-transferase K06975 - - 0.00000000000000000001521 96.0
TLS1_k127_6647880_16 PFAM phosphoesterase, PA-phosphatase related - - - 0.0000000000000008401 91.0
TLS1_k127_6647880_18 - - - - 0.000000000189 70.0
TLS1_k127_6647880_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 424.0
TLS1_k127_6647880_3 Aminotransferase class I and II K11358 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 410.0
TLS1_k127_6647880_4 carbon starvation protein CstA K06200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 389.0
TLS1_k127_6647880_5 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 336.0
TLS1_k127_6647880_6 - - - - 0.000000000000000000000000000000000000000000000000000000001417 205.0
TLS1_k127_6647880_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000162 201.0
TLS1_k127_6647880_9 helicase superfamily c-terminal domain K03654 - 3.6.4.12 0.000000000000000000000000000000000000004859 152.0
TLS1_k127_6659553_0 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 356.0
TLS1_k127_6659553_1 Transglycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002842 301.0
TLS1_k127_6659553_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000001008 235.0
TLS1_k127_6659553_3 Magnesium transport protein CorA K03284 - - 0.000000000000000000000000000000000000000000000001048 188.0
TLS1_k127_6659553_4 AI-2E family transporter - - - 0.000000000000000000000000000009001 133.0
TLS1_k127_6659553_5 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000002202 87.0
TLS1_k127_6659553_6 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K13940 GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 0.00008575 52.0
TLS1_k127_666341_0 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 345.0
TLS1_k127_666341_1 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 326.0
TLS1_k127_666341_2 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008086 296.0
TLS1_k127_666341_3 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001411 281.0
TLS1_k127_666341_4 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000006269 193.0
TLS1_k127_666341_5 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000002037 175.0
TLS1_k127_6701837_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 408.0
TLS1_k127_6701837_1 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000004159 261.0
TLS1_k127_6701837_10 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000001341 114.0
TLS1_k127_6701837_11 YCII-related domain - - - 0.000000000000003859 80.0
TLS1_k127_6701837_12 - - - - 0.0000000002079 64.0
TLS1_k127_6701837_13 Glutaredoxin-like domain (DUF836) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000004367 57.0
TLS1_k127_6701837_14 chaperone-mediated protein folding - - - 0.0001371 56.0
TLS1_k127_6701837_2 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001118 252.0
TLS1_k127_6701837_3 Belongs to the class-I aminoacyl-tRNA synthetase family - - - 0.00000000000000000000000000000000000000000000000000000000004546 216.0
TLS1_k127_6701837_4 Electron transfer flavoprotein K03522 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000001069 211.0
TLS1_k127_6701837_5 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000007193 161.0
TLS1_k127_6701837_6 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000001281 160.0
TLS1_k127_6701837_7 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000001632 155.0
TLS1_k127_6701837_8 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.0000000000000000000000000000000000003349 159.0
TLS1_k127_6701837_9 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000001904 145.0
TLS1_k127_6709266_0 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000002973 239.0
TLS1_k127_6709266_1 D-alanyl-D-alanine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000001565 205.0
TLS1_k127_6709266_2 PFAM O-antigen polymerase - - - 0.0000000000000000000000000000000000000000000944 184.0
TLS1_k127_6709266_3 PKD domain K01179,K08651 - 3.2.1.4,3.4.21.66 0.0000000000000000000002824 111.0
TLS1_k127_6721177_0 UDP-glucoronosyl and UDP-glucosyl transferase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 8.422e-202 638.0
TLS1_k127_6721177_1 Alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 397.0
TLS1_k127_6721177_2 sugar isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 383.0
TLS1_k127_6721177_3 Osmosensitive K+ channel His kinase sensor domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008744 299.0
TLS1_k127_6721177_4 Serine threonine protein kinase involved in cell cycle control - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007502 299.0
TLS1_k127_6721177_5 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004281 263.0
TLS1_k127_6721177_6 Aminoglycoside phosphotransferase K16146 - 2.7.1.175 0.0000000000000000000000000000000000000000000000000000000000000000001333 246.0
TLS1_k127_6721177_7 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000002701 215.0
TLS1_k127_6721177_8 Protein of unknown function (DUF3037) - - - 0.000000000000000000000000000000000001588 147.0
TLS1_k127_6721177_9 SPTR D1CGX5 Response regulator receiver protein - - - 0.000000000000003857 81.0
TLS1_k127_6736535_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005378 505.0
TLS1_k127_6736535_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000073 303.0
TLS1_k127_6736535_10 negative regulation of DNA recombination - - - 0.0000000002168 69.0
TLS1_k127_6736535_2 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000008342 233.0
TLS1_k127_6736535_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000005856 190.0
TLS1_k127_6736535_4 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.000000000000000000000000000000000000000000001004 179.0
TLS1_k127_6736535_5 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000000146 128.0
TLS1_k127_6736535_6 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000001008 109.0
TLS1_k127_6736535_7 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000002103 122.0
TLS1_k127_6736535_8 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000001835 80.0
TLS1_k127_6736535_9 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000003075 84.0
TLS1_k127_6747581_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 583.0
TLS1_k127_6747581_1 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 460.0
TLS1_k127_6747581_10 DNA-binding transcription factor activity K03892 - - 0.0000000000003039 74.0
TLS1_k127_6747581_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000001108 66.0
TLS1_k127_6747581_12 - - - - 0.0007687 49.0
TLS1_k127_6747581_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 352.0
TLS1_k127_6747581_3 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000001524 229.0
TLS1_k127_6747581_4 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000003582 212.0
TLS1_k127_6747581_5 Mediates influx of magnesium ions K03284 GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - 0.00000000000000000000000000000000000000000000004845 184.0
TLS1_k127_6747581_6 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000001449 103.0
TLS1_k127_6747581_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000696 93.0
TLS1_k127_6747581_8 Redoxin - - - 0.00000000000000002302 92.0
TLS1_k127_6747581_9 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.00000000000000002543 91.0
TLS1_k127_6755905_0 PFAM Dak kinase K05878 - 2.7.1.121 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 488.0
TLS1_k127_6755905_1 metallopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 421.0
TLS1_k127_6755905_10 Polysaccharide biosynthesis C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001663 241.0
TLS1_k127_6755905_11 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.00000000000000000000000000000000000000000000003945 192.0
TLS1_k127_6755905_12 - - - - 0.0000000000000000000000000000000000000000001141 174.0
TLS1_k127_6755905_13 PFAM Polysaccharide deacetylase - - - 0.0000000000000000000000000006347 128.0
TLS1_k127_6755905_14 polygalacturonase activity K07407 - 3.2.1.22 0.000000000000000000000000003838 129.0
TLS1_k127_6755905_15 Aminoglycoside phosphotransferase - - - 0.0000000000000000002815 99.0
TLS1_k127_6755905_16 Calcineurin-like phosphoesterase - - - 0.000000000000000000758 102.0
TLS1_k127_6755905_17 Chain length determinant protein - - - 0.0000000006075 69.0
TLS1_k127_6755905_18 Aminoglycoside phosphotransferase - - - 0.0007723 53.0
TLS1_k127_6755905_2 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 379.0
TLS1_k127_6755905_3 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 353.0
TLS1_k127_6755905_4 D-isomer specific 2-hydroxyacid dehydrogenase K00058,K16843 - 1.1.1.310,1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 335.0
TLS1_k127_6755905_5 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 336.0
TLS1_k127_6755905_6 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K00066 GO:0000271,GO:0003674,GO:0003824,GO:0003979,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576 1.1.1.132,1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 313.0
TLS1_k127_6755905_7 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K01841 - 5.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000001092 242.0
TLS1_k127_6755905_8 Dak2 K05879 - 2.7.1.121 0.000000000000000000000000000000000000000000000000000000000000000002332 233.0
TLS1_k127_6755905_9 Putative sugar-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004063 235.0
TLS1_k127_6856958_0 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 576.0
TLS1_k127_6856958_1 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005144 612.0
TLS1_k127_6856958_2 Histidine kinase K20976 - - 0.0000006085 55.0
TLS1_k127_692698_0 N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003399 288.0
TLS1_k127_692698_1 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000008869 189.0
TLS1_k127_692698_2 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000001348 125.0
TLS1_k127_692698_3 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000001795 82.0
TLS1_k127_6993747_0 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 543.0
TLS1_k127_6993747_1 Fe-S oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 530.0
TLS1_k127_6993747_10 Putative stress-induced transcription regulator - - - 0.00000000000001038 78.0
TLS1_k127_6993747_11 rRNA binding - - - 0.00000000004645 68.0
TLS1_k127_6993747_12 Protein of unknown function (DUF1461) - - - 0.000000001371 68.0
TLS1_k127_6993747_14 - - - - 0.0008417 51.0
TLS1_k127_6993747_2 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 499.0
TLS1_k127_6993747_3 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000005821 279.0
TLS1_k127_6993747_4 Peptidase family M50 K06212,K06402 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000008942 202.0
TLS1_k127_6993747_5 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000001414 178.0
TLS1_k127_6993747_6 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000003433 153.0
TLS1_k127_6993747_7 - - - - 0.00000000000000000000003043 106.0
TLS1_k127_6993747_8 SnoaL-like domain - - - 0.0000000000000000005554 94.0
TLS1_k127_6993747_9 Predicted integral membrane protein (DUF2269) - - - 0.0000000000000003222 86.0
TLS1_k127_7104041_0 FAD dependent oxidoreductase central domain K19191 - 1.5.3.19 1.478e-289 912.0
TLS1_k127_7104041_1 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 565.0
TLS1_k127_7104041_10 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005475 286.0
TLS1_k127_7104041_11 TIGRFAM competence damage-inducible protein CinA N-terminal domain K03742 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000004871 257.0
TLS1_k127_7104041_12 Choline/ethanolamine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000102 232.0
TLS1_k127_7104041_13 Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000003356 239.0
TLS1_k127_7104041_14 Inositol monophosphatase family K01092,K05602 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008934,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016053,GO:0016137,GO:0016138,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052745,GO:0052803,GO:0052834,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659 3.1.3.15,3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000007247 229.0
TLS1_k127_7104041_15 helix_turn_helix, cAMP Regulatory protein K01420,K10914,K21561,K21564 - - 0.0000000000000000000000000000000000000000000007281 176.0
TLS1_k127_7104041_16 GCN5 family acetyltransferase - - - 0.000000000000000000000000000000000000000000005305 185.0
TLS1_k127_7104041_17 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000001455 158.0
TLS1_k127_7104041_19 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000719 88.0
TLS1_k127_7104041_2 Fructose-bisphosphate aldolase class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 449.0
TLS1_k127_7104041_3 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 419.0
TLS1_k127_7104041_4 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003445 400.0
TLS1_k127_7104041_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 379.0
TLS1_k127_7104041_6 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 334.0
TLS1_k127_7104041_7 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 296.0
TLS1_k127_7104041_8 Binding-protein-dependent transport system inner membrane component K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005974 292.0
TLS1_k127_7104041_9 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 301.0
TLS1_k127_7109475_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.125e-253 824.0
TLS1_k127_7109475_1 Rhamnan synthesis protein F K07272,K20444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004996 262.0
TLS1_k127_7109475_2 galactose-6-phosphate isomerase activity K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000003204 178.0
TLS1_k127_7109475_3 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000282 158.0
TLS1_k127_7109475_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.000000001181 61.0
TLS1_k127_7185726_0 Isochorismatase family K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000001685 235.0
TLS1_k127_7185726_1 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000002654 211.0
TLS1_k127_7185726_2 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.000000000000000000000000000000000000000000001167 168.0
TLS1_k127_7185726_3 Cellulase (glycosyl hydrolase family 5) - - - 0.00003676 55.0
TLS1_k127_7205370_0 - - - - 0.00000000000000000000000000000000001683 137.0
TLS1_k127_7205370_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000003388 146.0
TLS1_k127_7205370_3 SnoaL-like domain - - - 0.0000000000000000000000000000002379 130.0
TLS1_k127_7205370_4 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000000000000001873 88.0
TLS1_k127_7205370_5 Major Facilitator Superfamily - - - 0.0000000000000256 74.0
TLS1_k127_7205370_7 - - - - 0.0001088 45.0
TLS1_k127_7206695_0 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001462 258.0
TLS1_k127_7206695_1 Sigma-70, region 4 type 2 K11618 - - 0.0000000000000000000000000000000000000000000000000000000000002462 220.0
TLS1_k127_7206695_10 - - - - 0.0000007232 58.0
TLS1_k127_7206695_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000002553 209.0
TLS1_k127_7206695_3 histidine kinase, dimerisation and phosphoacceptor region - - - 0.0000000000000000000000000000000000000002001 176.0
TLS1_k127_7206695_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000005818 129.0
TLS1_k127_7206695_5 - - - - 0.0000000000000000000000000003297 123.0
TLS1_k127_7206695_6 PucR C-terminal helix-turn-helix domain - - - 0.000000000000002783 93.0
TLS1_k127_7206695_7 helix_turn_helix, Lux Regulon - - - 0.00000000000006467 77.0
TLS1_k127_7206695_8 PFAM blue (type 1) copper domain protein - - - 0.00000000002228 74.0
TLS1_k127_7206695_9 PucR C-terminal helix-turn-helix domain - - - 0.00000001306 70.0
TLS1_k127_720775_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 529.0
TLS1_k127_720775_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 318.0
TLS1_k127_720775_10 - - - - 0.00000000000000000000000000000000000000000005503 178.0
TLS1_k127_720775_11 transcriptional - - - 0.000000000000000000000000000000000000002635 154.0
TLS1_k127_720775_12 coenzyme F420 binding - - - 0.000000000000000000000000000000007266 132.0
TLS1_k127_720775_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000007154 110.0
TLS1_k127_720775_14 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000005197 111.0
TLS1_k127_720775_15 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase - - - 0.000000000000000000001251 105.0
TLS1_k127_720775_16 - - - - 0.0000000000000000007268 96.0
TLS1_k127_720775_17 Cd(II) Pb(II)-responsive transcriptional regulator - - - 0.000000000000002267 82.0
TLS1_k127_720775_18 Putative stress-induced transcription regulator - - - 0.000000000000007243 84.0
TLS1_k127_720775_19 PFAM FAD binding domain of DNA photolyase K01669 GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 0.0000000000000805 81.0
TLS1_k127_720775_2 COGs COG3367 conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000796 312.0
TLS1_k127_720775_20 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.000000000001049 78.0
TLS1_k127_720775_3 tyrosinase K00505 - 1.14.18.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 304.0
TLS1_k127_720775_4 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 298.0
TLS1_k127_720775_5 Protein of unknown function (DUF2652) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004005 269.0
TLS1_k127_720775_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001763 226.0
TLS1_k127_720775_7 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000002165 237.0
TLS1_k127_720775_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000002811 201.0
TLS1_k127_720775_9 COG0346 Lactoylglutathione lyase and related lyases - - - 0.0000000000000000000000000000000000000000000000002397 183.0
TLS1_k127_7212262_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 525.0
TLS1_k127_7212262_1 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K10441,K10545,K10548 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000064 463.0
TLS1_k127_7212262_10 ABC transporter, ATP-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006679 287.0
TLS1_k127_7212262_11 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003964 265.0
TLS1_k127_7212262_12 N-acetylglucosaminylinositol deacetylase activity K18455 - 3.5.1.115 0.00000000000000000000000000000000000000000000000000000000000000000000000000003991 268.0
TLS1_k127_7212262_13 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001549 268.0
TLS1_k127_7212262_14 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006483 281.0
TLS1_k127_7212262_15 Capsule synthesis protein, CapA K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001042 270.0
TLS1_k127_7212262_16 Domain of unknown function (DUF4162) K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001777 257.0
TLS1_k127_7212262_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000136 232.0
TLS1_k127_7212262_18 SIS domain K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000005169 235.0
TLS1_k127_7212262_19 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000838 229.0
TLS1_k127_7212262_2 CoA-transferase family III K18702 - 2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007671 392.0
TLS1_k127_7212262_20 PFAM periplasmic binding protein K10439 - - 0.000000000000000000000000000000000000000000000000000000000003881 222.0
TLS1_k127_7212262_21 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000001306 210.0
TLS1_k127_7212262_22 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000004445 211.0
TLS1_k127_7212262_23 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000009774 198.0
TLS1_k127_7212262_24 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000001863 204.0
TLS1_k127_7212262_25 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.00000000000000000000000000000000000000000000000000003691 200.0
TLS1_k127_7212262_26 Domain of unknown function (DUF1905) - - - 0.000000000000000000000000000000000000000000000000000155 190.0
TLS1_k127_7212262_27 purine nucleotide biosynthetic process K02529 - - 0.00000000000000000000000000000000000000000000000007472 192.0
TLS1_k127_7212262_28 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000001444 187.0
TLS1_k127_7212262_29 Acetyltransferase (GNAT) domain K00663 - 2.3.1.82 0.0000000000000000000000000000000000000000000000002136 184.0
TLS1_k127_7212262_3 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 350.0
TLS1_k127_7212262_30 transcriptional - - - 0.000000000000000000000000000000000000000000000001597 176.0
TLS1_k127_7212262_31 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K12132 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.11.1,5.2.1.8 0.0000000000000000000000000000000000000000000001694 177.0
TLS1_k127_7212262_32 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000001377 170.0
TLS1_k127_7212262_33 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000023 142.0
TLS1_k127_7212262_34 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K12132 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.11.1,5.2.1.8 0.0000000000000000000000000000000001514 142.0
TLS1_k127_7212262_35 TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000004973 132.0
TLS1_k127_7212262_36 YjbR - - - 0.0000000000000000000000000005445 128.0
TLS1_k127_7212262_37 - - - - 0.000000000000000000000000001639 127.0
TLS1_k127_7212262_38 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000001736 108.0
TLS1_k127_7212262_39 ECF sigma factor K03088 - - 0.000000000000000000000001781 110.0
TLS1_k127_7212262_4 Belongs to the glycosyl hydrolase family 6 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 370.0
TLS1_k127_7212262_40 pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000329 113.0
TLS1_k127_7212262_41 Psort location CytoplasmicMembrane, score K01992 - - 0.000000000000000000000006973 117.0
TLS1_k127_7212262_42 - - - - 0.0000000000000000000001546 101.0
TLS1_k127_7212262_43 alcohol dehydrogenase - - - 0.000000000000000000003674 99.0
TLS1_k127_7212262_44 Pfam:Pyridox_oxidase - - - 0.0000000000000000001616 94.0
TLS1_k127_7212262_45 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000004793 89.0
TLS1_k127_7212262_46 alcohol dehydrogenase - - - 0.000000000009969 71.0
TLS1_k127_7212262_47 Helix-turn-helix domain - - - 0.00000000006573 68.0
TLS1_k127_7212262_48 exo-alpha-(2->6)-sialidase activity - - - 0.00000000006735 76.0
TLS1_k127_7212262_49 Sigma-70 region 2 - - - 0.000000000128 69.0
TLS1_k127_7212262_5 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006419 353.0
TLS1_k127_7212262_51 Phospholipase_D-nuclease N-terminal - - - 0.0000000008905 65.0
TLS1_k127_7212262_52 WD40-like Beta Propeller Repeat K03641 - - 0.000000001836 70.0
TLS1_k127_7212262_54 Transcriptional regulatory protein, C terminal - - - 0.0000003954 62.0
TLS1_k127_7212262_55 alcohol dehydrogenase - - - 0.00006775 53.0
TLS1_k127_7212262_57 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0006651 43.0
TLS1_k127_7212262_6 Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003559 337.0
TLS1_k127_7212262_7 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005528 308.0
TLS1_k127_7212262_8 Branched-chain amino acid transport system / permease component K02057,K10440,K17209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 304.0
TLS1_k127_7212262_9 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 302.0
TLS1_k127_7215137_0 PHP domain protein K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 490.0
TLS1_k127_7215137_1 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000001034 240.0
TLS1_k127_7215137_2 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000008177 173.0
TLS1_k127_7215137_3 polysaccharide deacetylase K15531 - 3.2.1.156 0.000000000000000000000000000000000000005448 169.0
TLS1_k127_7215137_4 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000000000004995 159.0
TLS1_k127_7215137_5 Diguanylate cyclase - - - 0.00000000000000000000000000001462 138.0
TLS1_k127_7215137_6 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000001363 128.0
TLS1_k127_7252779_0 Protein of unknown function (DUF998) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005961 252.0
TLS1_k127_7252779_1 PIN domain - - - 0.00000000000000000000000000000001936 130.0
TLS1_k127_7252779_2 Secreted repeat of unknown function - - - 0.0000000000000000000000000001454 123.0
TLS1_k127_7252779_3 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000001725 98.0
TLS1_k127_7252779_4 deoxyhypusine monooxygenase activity - - - 0.000000000001599 81.0
TLS1_k127_7252779_5 PIN domain - - - 0.000000000002644 72.0
TLS1_k127_7349131_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.848e-227 733.0
TLS1_k127_7349131_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 619.0
TLS1_k127_7349131_10 SnoaL-like domain - - - 0.00000003025 66.0
TLS1_k127_7349131_2 DNA segregation ATPase FtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 449.0
TLS1_k127_7349131_3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008168 387.0
TLS1_k127_7349131_4 Mur ligase family, catalytic domain K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000001285 235.0
TLS1_k127_7349131_5 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000005522 214.0
TLS1_k127_7349131_6 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000004029 178.0
TLS1_k127_7349131_7 Competence-damaged protein K03742 - 3.5.1.42 0.0000000000000000000000000000000005349 139.0
TLS1_k127_7349131_8 SMART helix-turn-helix domain protein - - - 0.0000000000000001499 93.0
TLS1_k127_7349131_9 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000001902 83.0
TLS1_k127_736530_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 448.0
TLS1_k127_736530_1 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000001145 271.0
TLS1_k127_736530_2 High-affinity nickel-transport protein K08970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008401 262.0
TLS1_k127_736530_3 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000004037 265.0
TLS1_k127_736530_4 PFAM flavin reductase domain protein, FMN-binding K16048 - - 0.000000000000000000000000000001057 139.0
TLS1_k127_736530_5 Alpha/beta hydrolase family - - - 0.000000000000000000000005856 116.0
TLS1_k127_736530_6 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000002958 74.0
TLS1_k127_736530_7 Methylmuconolactone methyl-isomerase - - - 0.000000007758 65.0
TLS1_k127_736530_8 Belongs to the UPF0354 family - - - 0.00000001131 65.0
TLS1_k127_7399566_0 Lipase maturation factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 596.0
TLS1_k127_7399566_1 DEAD DEAH box helicase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 515.0
TLS1_k127_7399566_10 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 336.0
TLS1_k127_7399566_11 Neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 320.0
TLS1_k127_7399566_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 304.0
TLS1_k127_7399566_13 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003002 287.0
TLS1_k127_7399566_14 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000232 276.0
TLS1_k127_7399566_15 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002407 301.0
TLS1_k127_7399566_16 B3/4 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001624 258.0
TLS1_k127_7399566_17 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001242 253.0
TLS1_k127_7399566_18 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000754 244.0
TLS1_k127_7399566_19 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000004918 232.0
TLS1_k127_7399566_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 452.0
TLS1_k127_7399566_20 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000006482 239.0
TLS1_k127_7399566_21 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000001294 216.0
TLS1_k127_7399566_22 Protein of unknown function (DUF3616) - - - 0.000000000000000000000000000000000000000000000000000000007627 203.0
TLS1_k127_7399566_23 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000000000000000000000001007 203.0
TLS1_k127_7399566_24 Domain of unknown function (DUF3291) - - - 0.000000000000000000000000000000000000000000000000000001209 202.0
TLS1_k127_7399566_25 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.000000000000000000000000000000000000000000000005047 182.0
TLS1_k127_7399566_26 PFAM HhH-GPD family protein - - - 0.000000000000000000000000000000000000000000000008158 180.0
TLS1_k127_7399566_28 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000009306 176.0
TLS1_k127_7399566_29 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000011 166.0
TLS1_k127_7399566_3 metallocarboxypeptidase activity K05996 - 3.4.17.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 411.0
TLS1_k127_7399566_30 Beta-lactamase K01286 - 3.4.16.4 0.00000000000000000000000000000000000000000283 177.0
TLS1_k127_7399566_31 Phosphotransferase enzyme family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000002342 163.0
TLS1_k127_7399566_32 PAC2 family - - - 0.00000000000000000000000000000000000000003402 170.0
TLS1_k127_7399566_33 menaquinone-dependent protoporphyrinogen oxidase activity K00230 - 1.3.5.3 0.0000000000000000000000000000000000001743 151.0
TLS1_k127_7399566_34 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template - - - 0.000000000000000000000000000000000000575 143.0
TLS1_k127_7399566_35 glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.00000000000000000000000000000000001881 138.0
TLS1_k127_7399566_37 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000001576 138.0
TLS1_k127_7399566_38 - - - - 0.00000000000000000000000000000001309 133.0
TLS1_k127_7399566_39 - - - - 0.00000000000000000000000000378 123.0
TLS1_k127_7399566_4 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 411.0
TLS1_k127_7399566_40 Domain of unknown function (DUF4112) - - - 0.00000000000000000000000001078 116.0
TLS1_k127_7399566_41 Protein of unknown function (DUF2089) - - - 0.00000000000000000000000003542 113.0
TLS1_k127_7399566_42 Cupin - - - 0.000000000000000000000000116 110.0
TLS1_k127_7399566_43 membrane - - - 0.0000000000000000000000001922 119.0
TLS1_k127_7399566_44 - - - - 0.00000000000000000000001067 111.0
TLS1_k127_7399566_45 membrane protein of uknown function UCP014873 - - - 0.000000000000000000000582 102.0
TLS1_k127_7399566_46 G5 - - - 0.000000000000000000001362 107.0
TLS1_k127_7399566_48 Belongs to the peptidase S8 family - - - 0.00000000000000000001671 103.0
TLS1_k127_7399566_49 Pfam:DUF385 - - - 0.0000000000000000037 90.0
TLS1_k127_7399566_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 373.0
TLS1_k127_7399566_50 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000002519 81.0
TLS1_k127_7399566_51 Putative adhesin - - - 0.0000000000006896 81.0
TLS1_k127_7399566_52 Tetratricopeptide repeat - - - 0.00000000009596 69.0
TLS1_k127_7399566_53 membrane - - - 0.0000000001622 72.0
TLS1_k127_7399566_54 Cold shock protein domain - - - 0.0000000003624 63.0
TLS1_k127_7399566_56 Transmembrane secretion effector - - - 0.000000001558 70.0
TLS1_k127_7399566_57 PspC domain K03973 - - 0.000000002836 66.0
TLS1_k127_7399566_58 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000001073 60.0
TLS1_k127_7399566_59 - - - - 0.000007318 57.0
TLS1_k127_7399566_6 histidine kinase A domain protein domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 362.0
TLS1_k127_7399566_60 acetyltransferase - - - 0.000008841 57.0
TLS1_k127_7399566_7 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000717 356.0
TLS1_k127_7399566_8 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 332.0
TLS1_k127_7399566_9 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006314 328.0
TLS1_k127_7405889_0 ATPases associated with a variety of cellular activities K10112,K10195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 455.0
TLS1_k127_7405889_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002854 248.0
TLS1_k127_7405889_2 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000001527 190.0
TLS1_k127_7405889_3 DOMON domain-containing protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0012505,GO:0031410,GO:0031982,GO:0031984,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0097708,GO:0098791 - 0.00000000000000000000000000000039 139.0
TLS1_k127_7422454_0 Malate synthase K01638 - 2.3.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007437 574.0
TLS1_k127_7422454_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 393.0
TLS1_k127_7423444_0 ABC transporter K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 336.0
TLS1_k127_7423444_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 310.0
TLS1_k127_7423444_2 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005259 285.0
TLS1_k127_7423444_3 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000001716 228.0
TLS1_k127_7423444_4 redox protein regulator of disulfide bond formation K07397 - - 0.000000000000000001895 98.0
TLS1_k127_7423444_5 Domain of unknown function (DUF4395) - - - 0.0000000000002371 77.0
TLS1_k127_7423444_6 Helix-turn-helix domain K00790 - 2.5.1.7 0.0002075 48.0
TLS1_k127_7521792_0 TIGRFAM Ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 473.0
TLS1_k127_7521792_1 PFAM aminotransferase, class I K00812,K10907 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 464.0
TLS1_k127_7521792_10 oxidoreductase activity, acting on diphenols and related substances as donors K02636,K03886 - 1.10.9.1 0.0000000000000000000000003335 113.0
TLS1_k127_7521792_11 Rhodanese Homology Domain - - - 0.0000000000000000002093 99.0
TLS1_k127_7521792_12 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000006304 86.0
TLS1_k127_7521792_13 SAM-dependent methyltransferase - - - 0.000000000003386 74.0
TLS1_k127_7521792_14 Galactose oxidase, central domain - - - 0.000002587 61.0
TLS1_k127_7521792_15 Cytochrome c, class I - - - 0.00004123 55.0
TLS1_k127_7521792_2 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K15893 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 383.0
TLS1_k127_7521792_3 Cytochrome b/b6/petB K03891 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 339.0
TLS1_k127_7521792_4 glutamate synthase, alpha subunit domain protein K00284 - 1.4.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000007535 269.0
TLS1_k127_7521792_5 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008854 248.0
TLS1_k127_7521792_6 'glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000001915 226.0
TLS1_k127_7521792_7 Domain of unknown function (DUF4287) - - - 0.000000000000000000000000000000000000000000000000000000003185 205.0
TLS1_k127_7521792_8 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000007074 214.0
TLS1_k127_7521792_9 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.00000000000000000000000000000000000000003242 162.0
TLS1_k127_7592825_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 590.0
TLS1_k127_7592825_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 396.0
TLS1_k127_7592825_2 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.00000000000000000000000000000005411 133.0
TLS1_k127_7592825_3 Peptidoglycan-binding LysM - - - 0.0000000000000000000000000000002477 141.0
TLS1_k127_7592825_4 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - - 0.00000002242 68.0
TLS1_k127_7598626_0 GXGXG motif K00265 - 1.4.1.13,1.4.1.14 1.854e-282 907.0
TLS1_k127_7598626_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 465.0
TLS1_k127_7598626_2 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000000000000000000000000007123 206.0
TLS1_k127_7598626_3 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000007678 156.0
TLS1_k127_7598626_4 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000002464 157.0
TLS1_k127_7598626_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000002955 137.0
TLS1_k127_7598626_6 acetyltransferase - - - 0.00000000005874 74.0
TLS1_k127_7630935_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 4.66e-231 738.0
TLS1_k127_7630935_1 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 391.0
TLS1_k127_7630935_10 Sporulation and spore germination - - - 0.00000000000000000000000000000000000000000000000000000001607 209.0
TLS1_k127_7630935_11 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000000000000000000006307 198.0
TLS1_k127_7630935_12 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000282 181.0
TLS1_k127_7630935_13 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000005362 181.0
TLS1_k127_7630935_14 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000000000000871 164.0
TLS1_k127_7630935_15 CHAD - - - 0.0000000000000000000000000000000000000000001285 181.0
TLS1_k127_7630935_16 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000002067 160.0
TLS1_k127_7630935_17 ABC-type Na efflux pump, permease component K01992 - - 0.0000000000000000000000000000000000003065 158.0
TLS1_k127_7630935_18 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000001198 139.0
TLS1_k127_7630935_19 ATPase histidine kinase DNA gyrase B HSP90 domain protein K02484,K07654 - 2.7.13.3 0.0000000000000000000000000113 114.0
TLS1_k127_7630935_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 392.0
TLS1_k127_7630935_20 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000001984 121.0
TLS1_k127_7630935_21 PFAM ATP dependent DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000004107 116.0
TLS1_k127_7630935_22 Protein of unknown function (DUF971) - - - 0.0000000000000000000000004455 109.0
TLS1_k127_7630935_23 endonuclease exonuclease phosphatase - - - 0.0000000000000000000000009378 116.0
TLS1_k127_7630935_24 transcriptional regulator K03892 - - 0.0000000000000000001033 98.0
TLS1_k127_7630935_25 Phosphohistidine phosphatase, SixA K08296 - - 0.00000000003704 70.0
TLS1_k127_7630935_3 phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 340.0
TLS1_k127_7630935_4 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 312.0
TLS1_k127_7630935_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 310.0
TLS1_k127_7630935_6 ABC transporter, ATP-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003007 280.0
TLS1_k127_7630935_7 Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006174 253.0
TLS1_k127_7630935_8 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000111 258.0
TLS1_k127_7630935_9 converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.000000000000000000000000000000000000000000000000000000000000008026 240.0
TLS1_k127_7648536_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008923 490.0
TLS1_k127_7648536_1 2Fe-2S iron-sulfur cluster binding domain K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009824 442.0
TLS1_k127_7648536_2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 339.0
TLS1_k127_7648536_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 299.0
TLS1_k127_7648536_4 chloramphenicol K18554 - - 0.00000000000000000000000000000000000000000004049 182.0
TLS1_k127_7648536_5 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000004831 130.0
TLS1_k127_7648536_6 Uncharacterized conserved protein (DUF2277) - - - 0.00000000006932 70.0
TLS1_k127_7648536_7 - - - - 0.000007424 58.0
TLS1_k127_7656402_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 2.473e-199 637.0
TLS1_k127_7656402_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 627.0
TLS1_k127_7656402_10 helix_turn_helix, Lux Regulon K02479 - - 0.000000000000000000000000000000000000000000007919 171.0
TLS1_k127_7656402_11 Prephenate dehydrogenase K00210,K00220,K04517 - 1.3.1.12,1.3.1.43 0.000000000000000000000000000000000000001835 158.0
TLS1_k127_7656402_12 - - - - 0.0000000000000000000000000000001216 138.0
TLS1_k127_7656402_13 Prolyl oligopeptidase family K06889 - - 0.000000000000000001148 100.0
TLS1_k127_7656402_14 - - - - 0.000006265 54.0
TLS1_k127_7656402_15 Protein of unknown function (DUF3494) - - - 0.000006779 59.0
TLS1_k127_7656402_2 magnesium chelatase, ChlI subunit K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 417.0
TLS1_k127_7656402_3 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 311.0
TLS1_k127_7656402_4 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001755 297.0
TLS1_k127_7656402_5 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008497 268.0
TLS1_k127_7656402_6 PFAM response regulator receiver K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001621 267.0
TLS1_k127_7656402_7 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000007736 260.0
TLS1_k127_7656402_8 tyrosine recombinase XerC K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000005047 224.0
TLS1_k127_7656402_9 PFAM DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000006303 204.0
TLS1_k127_7701922_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 414.0
TLS1_k127_7701922_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 302.0
TLS1_k127_7701922_2 (ABC) transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004649 267.0
TLS1_k127_7701922_3 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000005231 221.0
TLS1_k127_7701922_4 aminopeptidase N - - - 0.0000000000000000000000172 113.0
TLS1_k127_7701922_5 Tetratricopeptide repeat - - - 0.0000000000002322 80.0
TLS1_k127_7721775_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 338.0
TLS1_k127_7721775_1 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005028 263.0
TLS1_k127_7721775_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000003093 209.0
TLS1_k127_7721775_3 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000292 114.0
TLS1_k127_7721775_4 GlcNAc-PI de-N-acetylase - - - 0.000000000000000002429 98.0
TLS1_k127_7721775_5 Glycosyl transferase K00728 - 2.4.1.109 0.00000000000000001192 96.0
TLS1_k127_7721775_6 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000001078 88.0
TLS1_k127_7721775_7 MFS transporter - - - 0.0000004291 56.0
TLS1_k127_7742839_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 7.202e-219 698.0
TLS1_k127_7742839_1 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 5.929e-206 661.0
TLS1_k127_7742839_10 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000006036 253.0
TLS1_k127_7742839_11 Colicin V production protein - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944 - 0.0000000000000000000000000000000000000000000000000006113 200.0
TLS1_k127_7742839_12 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000001065 197.0
TLS1_k127_7742839_13 ACT domain K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000001666 187.0
TLS1_k127_7742839_14 F420-dependent oxidoreductase, Rv1855c family - - - 0.00000000000000000000000000000000000000501 162.0
TLS1_k127_7742839_15 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000009608 130.0
TLS1_k127_7742839_16 malonyl CoA-acyl carrier protein transacylase K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.000000000000000000000000003286 122.0
TLS1_k127_7742839_17 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000455 116.0
TLS1_k127_7742839_18 Family of unknown function (DUF5317) - - - 0.0000000000000000183 94.0
TLS1_k127_7742839_19 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000001382 72.0
TLS1_k127_7742839_2 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 603.0
TLS1_k127_7742839_20 - - - - 0.0000000001606 73.0
TLS1_k127_7742839_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 456.0
TLS1_k127_7742839_4 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007099 447.0
TLS1_k127_7742839_5 Peptidase family M20/M25/M40 K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004465 323.0
TLS1_k127_7742839_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000084 301.0
TLS1_k127_7742839_7 Ferrous iron transport B domain protein K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001993 295.0
TLS1_k127_7742839_8 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000001654 258.0
TLS1_k127_7742839_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000006081 243.0
TLS1_k127_7755064_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 538.0
TLS1_k127_7755064_1 phenylalanyl-tRNA synthetase (beta subunit) K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 445.0
TLS1_k127_7755064_2 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.00000000000000000000000000000000006149 153.0
TLS1_k127_7755064_3 PFAM glycosyl transferase, family 51 - - - 0.0000000000000003083 88.0
TLS1_k127_7755064_4 Colicin V production protein K03558 - - 0.000004166 56.0
TLS1_k127_7756302_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.324e-261 825.0
TLS1_k127_7756302_1 Alpha amylase, catalytic domain K21350 - 2.4.1.329 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004739 524.0
TLS1_k127_7756302_10 Predicted membrane protein (DUF2231) - - - 0.00000000000000000000000000000000000000000000003414 179.0
TLS1_k127_7756302_11 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000006401 168.0
TLS1_k127_7756302_12 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.000000000000000000000000000000000000000004268 167.0
TLS1_k127_7756302_13 cheY-homologous receiver domain - - - 0.000000000000000000000000000000001374 132.0
TLS1_k127_7756302_14 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000002448 134.0
TLS1_k127_7756302_15 VIT family - - - 0.00000000000000000000000002785 120.0
TLS1_k127_7756302_16 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.000000000000000000000003655 108.0
TLS1_k127_7756302_17 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000004097 109.0
TLS1_k127_7756302_18 pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000001534 102.0
TLS1_k127_7756302_19 Beta-lactamase superfamily domain - - - 0.0000000000000005878 83.0
TLS1_k127_7756302_2 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 519.0
TLS1_k127_7756302_20 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.0004719 48.0
TLS1_k127_7756302_3 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 475.0
TLS1_k127_7756302_4 Protein involved in amylo-alpha-1,6-glucosidase activity and glycogen biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 464.0
TLS1_k127_7756302_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 309.0
TLS1_k127_7756302_6 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002945 269.0
TLS1_k127_7756302_7 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006729 263.0
TLS1_k127_7756302_8 Two component transcriptional regulator, winged helix family K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001763 255.0
TLS1_k127_7756302_9 PFAM aminoglycoside phosphotransferase K18844 - - 0.0000000000000000000000000000000000000000000000000006308 207.0
TLS1_k127_7768322_0 AcrB/AcrD/AcrF family - - - 0.0 1284.0
TLS1_k127_7768322_1 AcrB/AcrD/AcrF family - - - 1.244e-282 902.0
TLS1_k127_7768322_2 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 404.0
TLS1_k127_7768322_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001627 265.0
TLS1_k127_7768322_4 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.00000000000000000000000000000000000000000000000001158 189.0
TLS1_k127_7768322_5 TIGRFAM galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000001342 173.0
TLS1_k127_7768322_6 Response regulator receiver K07696 - - 0.0000000000000000000000000000000000000000005548 168.0
TLS1_k127_7768322_7 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000001498 131.0
TLS1_k127_7768322_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000003141 109.0
TLS1_k127_7768322_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000003704 97.0
TLS1_k127_7836058_0 Phosphoketolase K01621 - 4.1.2.22,4.1.2.9 9.204e-285 896.0
TLS1_k127_7836058_1 AAA ATPase domain - - - 2.43e-260 864.0
TLS1_k127_7836058_10 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 366.0
TLS1_k127_7836058_11 Multicopper oxidase K22348 - 1.16.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009821 341.0
TLS1_k127_7836058_12 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 333.0
TLS1_k127_7836058_13 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K03851,K15372 - 2.6.1.55,2.6.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 359.0
TLS1_k127_7836058_14 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 327.0
TLS1_k127_7836058_15 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000241 282.0
TLS1_k127_7836058_16 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000008365 265.0
TLS1_k127_7836058_17 Phosphotriesterase family K07048 - - 0.000000000000000000000000000000000000000000000000000000000000000007904 248.0
TLS1_k127_7836058_18 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.000000000000000000000000000000000000000000000000000000000000001544 231.0
TLS1_k127_7836058_19 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000002108 186.0
TLS1_k127_7836058_2 membrane K13277,K15125,K15539 - - 5.593e-232 782.0
TLS1_k127_7836058_20 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000108 177.0
TLS1_k127_7836058_21 Cytochrome C oxidase subunit II, periplasmic domain K02275 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.0000000000000000000000000000000000000000005218 167.0
TLS1_k127_7836058_22 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000000000000000007972 154.0
TLS1_k127_7836058_23 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000001225 147.0
TLS1_k127_7836058_24 OsmC-like protein K04063 - - 0.00000000000000000000000000001295 138.0
TLS1_k127_7836058_25 HYR domain - - - 0.000000000000000000000008208 120.0
TLS1_k127_7836058_26 Belongs to the Fur family K03711,K09825 - - 0.0000000000000000000001115 113.0
TLS1_k127_7836058_27 BetI-type transcriptional repressor, C-terminal - - - 0.000000000000000000001289 103.0
TLS1_k127_7836058_28 Cysteine-rich secretory protein family - - - 0.000000000000000008236 94.0
TLS1_k127_7836058_3 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 2.244e-213 690.0
TLS1_k127_7836058_30 - - - - 0.0000000000000305 83.0
TLS1_k127_7836058_31 Transglycosylase associated protein - - - 0.000000000001018 80.0
TLS1_k127_7836058_32 Copper binding proteins, plastocyanin/azurin family - - - 0.000000005009 66.0
TLS1_k127_7836058_33 Copper binding proteins, plastocyanin/azurin family - - - 0.00000002863 65.0
TLS1_k127_7836058_34 - - - - 0.000002018 52.0
TLS1_k127_7836058_35 Protein of unknown function (DUF642) - - - 0.00002539 59.0
TLS1_k127_7836058_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596,K00823 - 2.6.1.19,4.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 559.0
TLS1_k127_7836058_5 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 543.0
TLS1_k127_7836058_6 MMPL family K06994 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008027 527.0
TLS1_k127_7836058_7 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 407.0
TLS1_k127_7836058_8 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009377 393.0
TLS1_k127_7836058_9 Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 381.0
TLS1_k127_7840795_0 Belongs to the 5'-nucleotidase family K01081 - 3.1.3.5 1.084e-196 638.0
TLS1_k127_7840795_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 592.0
TLS1_k127_7840795_10 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000002713 235.0
TLS1_k127_7840795_11 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000009808 230.0
TLS1_k127_7840795_12 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000000000006782 209.0
TLS1_k127_7840795_13 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000001213 207.0
TLS1_k127_7840795_14 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000003547 208.0
TLS1_k127_7840795_15 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000006057 210.0
TLS1_k127_7840795_16 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000001953 203.0
TLS1_k127_7840795_17 InterPro IPR014922 - - - 0.00000000000000000000000000000000000000000000000004311 195.0
TLS1_k127_7840795_18 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000002303 183.0
TLS1_k127_7840795_19 PFAM VanW family protein - - - 0.0000000000000000000000000000000000000001845 171.0
TLS1_k127_7840795_2 HYR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007109 600.0
TLS1_k127_7840795_20 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000001698 154.0
TLS1_k127_7840795_21 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000002174 116.0
TLS1_k127_7840795_22 amino acid activation for nonribosomal peptide biosynthetic process K03641,K20276 - - 0.0000000000000000000000001127 123.0
TLS1_k127_7840795_23 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000000000000000001481 119.0
TLS1_k127_7840795_24 SnoaL-like domain - - - 0.00000000000000000000000164 107.0
TLS1_k127_7840795_25 May be required for sporulation K09762 - - 0.00000000000000000000001918 110.0
TLS1_k127_7840795_27 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000002155 81.0
TLS1_k127_7840795_28 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000002988 70.0
TLS1_k127_7840795_3 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 548.0
TLS1_k127_7840795_30 Dipeptidyl peptidase IV (DPP IV) N-terminal region K03641 - - 0.0000000001219 76.0
TLS1_k127_7840795_31 - - - - 0.000000002565 64.0
TLS1_k127_7840795_32 Belongs to the peptidase S8 family K14645 - - 0.00000005093 66.0
TLS1_k127_7840795_33 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000003616 55.0
TLS1_k127_7840795_34 Sigma-70, region 4 K03088 - - 0.0000007086 58.0
TLS1_k127_7840795_35 - - - - 0.0005682 49.0
TLS1_k127_7840795_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 502.0
TLS1_k127_7840795_5 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 342.0
TLS1_k127_7840795_6 Required for morphogenesis under gluconeogenic growth conditions - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 335.0
TLS1_k127_7840795_7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K01919,K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 326.0
TLS1_k127_7840795_8 Single-strand DNA-specific exonuclease, C terminal domain K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 316.0
TLS1_k127_7840795_9 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007925 259.0
TLS1_k127_788794_0 permease K06901 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 394.0
TLS1_k127_788794_1 glucose sorbosone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 372.0
TLS1_k127_788794_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 337.0
TLS1_k127_788794_3 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 321.0
TLS1_k127_788794_4 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 332.0
TLS1_k127_788794_5 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 317.0
TLS1_k127_788794_6 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 0.00000000000000000000000000000000000000000000000000000002117 207.0
TLS1_k127_788794_7 Lysyl oxidase - - - 0.000000000000000000000000000000000000000000000006364 183.0
TLS1_k127_788794_8 - - - - 0.00001273 54.0
TLS1_k127_7899866_0 ABC transporter - - - 5.027e-276 857.0
TLS1_k127_7899866_1 Aminotransferase class-III K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 615.0
TLS1_k127_7899866_10 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000001633 198.0
TLS1_k127_7899866_11 Histidine kinase - - - 0.00000000000000000000000000000000000000000000006989 189.0
TLS1_k127_7899866_12 Putative glycolipid-binding K09957 - - 0.00000000000000000000000000000000000000003869 160.0
TLS1_k127_7899866_13 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000002351 155.0
TLS1_k127_7899866_14 ribonuclease BN K07058 - - 0.0000000000000000000000000000000000002143 155.0
TLS1_k127_7899866_15 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000003498 135.0
TLS1_k127_7899866_16 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.000000000000000000000000000005322 124.0
TLS1_k127_7899866_17 - - - - 0.0000000000000000000000002686 109.0
TLS1_k127_7899866_18 COG0346 Lactoylglutathione lyase and related lyases K01759 - 4.4.1.5 0.0000000000000000000000004708 109.0
TLS1_k127_7899866_2 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 464.0
TLS1_k127_7899866_20 GyrI-like small molecule binding domain - - - 0.000000000000002061 85.0
TLS1_k127_7899866_21 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000003212 89.0
TLS1_k127_7899866_22 - - - - 0.000000000000007035 87.0
TLS1_k127_7899866_24 Belongs to the sigma-70 factor family K03088 - - 0.0000004217 59.0
TLS1_k127_7899866_3 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 409.0
TLS1_k127_7899866_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006844 355.0
TLS1_k127_7899866_5 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 296.0
TLS1_k127_7899866_6 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001523 254.0
TLS1_k127_7899866_7 Truncated hemoglobins K06886 - - 0.000000000000000000000000000000000000000000000000000000000000000000003602 237.0
TLS1_k127_7899866_8 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000007722 214.0
TLS1_k127_7899866_9 FR47-like protein K03829 - - 0.00000000000000000000000000000000000000000000000000005273 191.0
TLS1_k127_7904174_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006217 572.0
TLS1_k127_7904174_1 HD domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000943 283.0
TLS1_k127_7904174_2 CHRD domain - - - 0.00000000000000000000000000000003222 134.0
TLS1_k127_7904174_3 cheY-homologous receiver domain - - - 0.000000000000000000000008309 115.0
TLS1_k127_7904174_4 - - - - 0.000000001408 69.0
TLS1_k127_7904174_5 extracellular nuclease K07004 - - 0.000009252 51.0
TLS1_k127_7908299_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 8.809e-217 687.0
TLS1_k127_7908299_1 pyrroloquinoline quinone binding - - - 1.125e-206 656.0
TLS1_k127_7908299_2 IMS family HHH motif K02346 GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0050896 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 372.0
TLS1_k127_7908299_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000008411 267.0
TLS1_k127_7908299_4 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000001755 104.0
TLS1_k127_7908299_5 Formiminotransferase-cyclodeaminase - - - 0.0000000000000000000007008 109.0
TLS1_k127_7938809_0 Carboxyl transferase domain K01969 - 6.4.1.4 1.505e-234 745.0
TLS1_k127_7938809_1 R3H domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 481.0
TLS1_k127_7938809_2 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 443.0
TLS1_k127_7938809_3 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000007209 220.0
TLS1_k127_7938809_4 MOSC domain - - - 0.000000000000000000000000000000000005882 150.0
TLS1_k127_7938809_5 Belongs to the GbsR family - - - 0.0000000000107 74.0
TLS1_k127_8027309_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 582.0
TLS1_k127_8027309_1 RsgA GTPase K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 336.0
TLS1_k127_8027309_2 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 299.0
TLS1_k127_8027309_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008929 292.0
TLS1_k127_8027309_4 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004173 261.0
TLS1_k127_8027309_5 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000005601 220.0
TLS1_k127_8027309_6 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000003007 220.0
TLS1_k127_8027309_7 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000287 157.0
TLS1_k127_8027309_8 - - - - 0.0000000005694 61.0
TLS1_k127_8027309_9 von Willebrand factor (vWF) type A domain - - - 0.000000001489 63.0
TLS1_k127_8047356_0 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009737 500.0
TLS1_k127_8047356_1 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 395.0
TLS1_k127_8047356_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000008372 56.0
TLS1_k127_8047356_2 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000004246 264.0
TLS1_k127_8047356_3 Belongs to the HpcH HpaI aldolase family K01630,K02510 - 4.1.2.20,4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000003347 224.0
TLS1_k127_8047356_4 PIN domain - - - 0.0000000000000000000000000000000000006186 145.0
TLS1_k127_8047356_5 - - - - 0.00000000000000000000000000000000001504 143.0
TLS1_k127_8047356_7 ECF sigma factor K03088 - - 0.000000000000000000002437 109.0
TLS1_k127_8047356_8 Ribbon-helix-helix protein, copG family - - - 0.00000000000000007291 82.0
TLS1_k127_8047356_9 DNA-templated transcription, initiation K03088 - - 0.0000000000003854 78.0
TLS1_k127_903353_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 2.419e-319 1008.0
TLS1_k127_903353_1 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000002735 200.0
TLS1_k127_903353_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000219 171.0
TLS1_k127_903353_3 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000785 85.0
TLS1_k127_903353_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.00004851 50.0