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Overview

ID MAG03977
Name TLS1_bin.4
Sample SMP0103
Taxonomy
Kingdom Archaea
Phylum Thermoproteota
Class Nitrososphaeria
Order Nitrososphaerales
Family Nitrososphaeraceae
Genus TH5896
Species TH5896 sp014523695
Assembly information
Completeness (%) 65.44
Contamination (%) 1.38
GC content (%) 40.0
N50 (bp) 3,265
Genome size (bp) 986,115

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes958

Gene name Description KEGG GOs EC E-value Score Sequence
TLS1_k127_1059565_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 2.154e-219 687.0
TLS1_k127_1059565_1 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 304.0
TLS1_k127_1059565_2 UbiA prenyltransferase K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000867 271.0
TLS1_k127_1059565_3 Biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000001513 151.0
TLS1_k127_1075606_0 Binds the lower part of the 30S subunit head K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008417 307.0
TLS1_k127_1075606_1 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005548 253.0
TLS1_k127_1075606_2 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009431 253.0
TLS1_k127_1075606_3 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000000000001347 152.0
TLS1_k127_1075606_4 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000001931 132.0
TLS1_k127_1075606_5 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000005312 127.0
TLS1_k127_1075606_6 Located at the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000001474 119.0
TLS1_k127_1075606_7 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.000000000000003598 78.0
TLS1_k127_1075606_8 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000002831 53.0
TLS1_k127_1099909_0 inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 516.0
TLS1_k127_1099909_1 inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 413.0
TLS1_k127_1101301_0 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 457.0
TLS1_k127_1101301_1 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000805 240.0
TLS1_k127_1101301_3 Sugar phosphate isomerases epimerases - - - 0.000006245 49.0
TLS1_k127_1110085_0 DHHA1 domain K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 314.0
TLS1_k127_1110085_1 ribosomal protein K02956 - - 0.00000000000000000000000000000000000000000000000000005117 192.0
TLS1_k127_1110085_2 - - - - 0.000000000000000000000000000000000000004098 147.0
TLS1_k127_1110085_3 Radical SAM - - - 0.000000000000000000000000008706 110.0
TLS1_k127_1110085_4 - - - - 0.0005026 49.0
TLS1_k127_1112973_0 aldo-keto reductase (NADP) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 361.0
TLS1_k127_1115194_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 4.659e-264 835.0
TLS1_k127_1115194_1 Cob(II)yrinic acid a,c-diamide reductase K04719 - 1.13.11.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 334.0
TLS1_k127_1115194_2 - - - - 0.000001164 51.0
TLS1_k127_1148641_0 MiaB-like tRNA modifying enzyme K15865 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 488.0
TLS1_k127_1148641_1 PFAM Protein kinase domain - - - 0.000002317 55.0
TLS1_k127_1153094_0 DEAD DEAH box helicase K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 528.0
TLS1_k127_1153094_1 Zinc finger domain - - - 0.0000000000000000000000000000000000000000001905 162.0
TLS1_k127_118995_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007834 541.0
TLS1_k127_118995_1 DnaJ molecular chaperone homology domain K03686 - - 0.000000000000000000000000000000000000000004255 158.0
TLS1_k127_1280417_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004001 500.0
TLS1_k127_1300934_0 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006634 274.0
TLS1_k127_1300934_1 phosphoserine phosphatase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000006207 188.0
TLS1_k127_1300934_2 redox protein, regulator of disulfide bond formation - - - 0.0000000000000000000000000000000007597 131.0
TLS1_k127_1300934_3 Cysteine synthase K12339 - 2.5.1.47 0.000000000000000003396 85.0
TLS1_k127_1312978_0 DEAD/H associated K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000091 612.0
TLS1_k127_1312978_1 - - - - 0.000000000000000000000000000000000000000000000000321 177.0
TLS1_k127_1328187_0 TIGRFAM glutamine synthetase, type I K01915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 611.0
TLS1_k127_1328187_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000002047 209.0
TLS1_k127_1337696_0 synthetase (class II) K01880 - 6.1.1.14 4.324e-227 711.0
TLS1_k127_1337696_1 oxidoreductase FAD NAD(P)-binding K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000001658 158.0
TLS1_k127_1347029_0 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 5.81e-269 837.0
TLS1_k127_1347029_1 von Willebrand factor (vWF) type A domain - - - 1.519e-210 668.0
TLS1_k127_1347029_2 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 394.0
TLS1_k127_1347029_3 ATPase family associated with various cellular activities (AAA) K04748 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 374.0
TLS1_k127_1347029_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 329.0
TLS1_k127_1347029_5 PFAM Transketolase, C-terminal domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 321.0
TLS1_k127_1347029_6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000002026 78.0
TLS1_k127_1366799_0 Belongs to the enoyl-CoA hydratase isomerase family K01715,K15019 - 4.2.1.116,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000087 439.0
TLS1_k127_1366799_1 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 320.0
TLS1_k127_1366799_2 Conserved hypothetical ATP binding protein K06883 - - 0.00000000000000000000000000000000000003554 146.0
TLS1_k127_137867_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.0000002242 58.0
TLS1_k127_1389668_0 zinc-ribbon domain - - - 0.000000000000000000000000000000000004239 140.0
TLS1_k127_1389668_1 - - - - 0.00000002354 62.0
TLS1_k127_1449311_0 Pyridoxamine 5'-phosphate K07005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002328 276.0
TLS1_k127_1449311_1 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000541 219.0
TLS1_k127_1449311_2 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000589 187.0
TLS1_k127_1451629_0 DNA primase K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 558.0
TLS1_k127_1451629_1 Domain of unknown function DUF120 K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000000000000000000000009815 240.0
TLS1_k127_1451629_2 Cytidylyltransferase-like K00980,K14656 - 2.7.7.2,2.7.7.39 0.000000000000000000000000000000003613 129.0
TLS1_k127_1467626_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 404.0
TLS1_k127_1467626_1 Sua5 YciO YrdC YwlC family K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000004227 168.0
TLS1_k127_1467626_2 glycine decarboxylation via glycine cleavage system K02437 - - 0.0000000000000000000001279 106.0
TLS1_k127_1467626_3 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.0000000000000000000003812 96.0
TLS1_k127_1467626_4 restriction endonuclease K07448 - - 0.000000477 56.0
TLS1_k127_1468931_0 Radical SAM K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 469.0
TLS1_k127_1468931_1 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 314.0
TLS1_k127_1470738_0 LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 365.0
TLS1_k127_1470738_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000001035 261.0
TLS1_k127_1470738_2 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000001533 212.0
TLS1_k127_1470738_3 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000005097 146.0
TLS1_k127_1483232_1 Belongs to the urease beta subunit family K01429,K14048 - 3.5.1.5 0.000000000000000000000000000000000000000000000000003666 183.0
TLS1_k127_1483232_2 (urease) gamma subunit K01430,K14048 - 3.5.1.5 0.00000000000000000000000000000000000000000000000007496 179.0
TLS1_k127_1531977_0 Radical SAM K18285 - 2.5.1.120 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006101 584.0
TLS1_k127_1531977_1 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 320.0
TLS1_k127_1531977_2 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000003896 104.0
TLS1_k127_1531977_3 - - - - 0.00000000000000000007335 93.0
TLS1_k127_1543788_0 Belongs to the UPF0255 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 402.0
TLS1_k127_1543788_1 - - - - 0.000000000000002057 81.0
TLS1_k127_1543788_2 - - - - 0.000001328 51.0
TLS1_k127_1545327_0 Cobalt chelatase (CbiK) K06042 - 5.4.99.60,5.4.99.61 0.0000000000000000000000000000000000000000000000000000000000000000000003628 244.0
TLS1_k127_1545327_1 Cobalt chelatase (CbiK) K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000002458 242.0
TLS1_k127_1545327_2 PFAM CBS domain containing protein - - - 0.000000000001412 74.0
TLS1_k127_154768_0 epimerase K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 307.0
TLS1_k127_1558875_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 1.484e-196 624.0
TLS1_k127_1558875_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 424.0
TLS1_k127_1558875_2 Alpha mannosidase, middle domain K01191 - 3.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 325.0
TLS1_k127_1678781_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 300.0
TLS1_k127_1678781_1 multicopper - - - 0.0000000000000000001592 94.0
TLS1_k127_1710266_0 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000000000000002911 201.0
TLS1_k127_1710266_1 - - - - 0.000000000000000000000000000000000000000000000000003347 188.0
TLS1_k127_1710266_2 PFAM Glycosyl transferase family 2 K19003 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576 2.4.1.336 0.000000009127 66.0
TLS1_k127_1733869_0 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006951 257.0
TLS1_k127_1733869_1 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000003453 155.0
TLS1_k127_1737144_0 Isocitrate isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 423.0
TLS1_k127_1737144_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000001013 180.0
TLS1_k127_1737144_2 Lysine methyltransferase K02493 - 2.1.1.297 0.0000000000000006217 85.0
TLS1_k127_1737144_3 Protein of unknown function (DUF655) K07572 - - 0.0000000000003433 69.0
TLS1_k127_1753123_0 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K02548,K17105,K20616 - 2.5.1.42,2.5.1.74 0.0000000000000000000000000000000000000000000000000001253 200.0
TLS1_k127_1753123_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000002556 184.0
TLS1_k127_1777716_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 379.0
TLS1_k127_1777716_1 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000006177 237.0
TLS1_k127_1777716_2 - - - - 0.000000000000000000000000000000388 125.0
TLS1_k127_1777716_4 - - - - 0.0002964 44.0
TLS1_k127_1860659_0 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000002792 220.0
TLS1_k127_1860659_1 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000001292 173.0
TLS1_k127_1860659_2 - - - - 0.00000000000000000000000000000001135 128.0
TLS1_k127_1860659_3 of nitrite reductase and ring-hydroxylating K05710 - - 0.00000000000000000000000000002579 120.0
TLS1_k127_1860659_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000002228 70.0
TLS1_k127_1865055_0 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 527.0
TLS1_k127_1868811_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 460.0
TLS1_k127_1868811_1 PBS lyase HEAT-like repeat K06072 - 1.14.99.29 0.000000000000000000000000000000000000000000000000008557 184.0
TLS1_k127_189060_0 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 290.0
TLS1_k127_189060_1 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004521 283.0
TLS1_k127_189060_2 - - - - 0.000000000000000000000008842 104.0
TLS1_k127_1924992_0 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 420.0
TLS1_k127_1924992_1 PFAM Iron dependent repressor, metal binding and dimerisation domain K03709 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001615 252.0
TLS1_k127_1924992_2 PFAM TCP-1 cpn60 chaperonin family K22447 - - 0.000000000000000000000000000000000000000000000000000000009514 199.0
TLS1_k127_193438_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 609.0
TLS1_k127_1941007_0 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000002026 180.0
TLS1_k127_1941007_1 Major Intrinsic Protein K06188 - - 0.000000000000000000000000000000000000000000000005112 177.0
TLS1_k127_1941007_2 NAD(P)H-dependent FMN reductase K00299 - 1.5.1.38 0.000000000000000000000006379 103.0
TLS1_k127_1951917_0 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 459.0
TLS1_k127_1951917_1 glutamine amidotransferase K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000006208 170.0
TLS1_k127_1951917_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000008442 98.0
TLS1_k127_1955651_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 472.0
TLS1_k127_1955651_1 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 327.0
TLS1_k127_1955651_2 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000003572 96.0
TLS1_k127_1970079_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 4.634e-249 788.0
TLS1_k127_1970079_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 563.0
TLS1_k127_1970079_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 304.0
TLS1_k127_1970079_3 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000002696 128.0
TLS1_k127_1970079_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000003794 93.0
TLS1_k127_1972381_0 COG1960 Acyl-CoA dehydrogenases K00252 - 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 563.0
TLS1_k127_1972381_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004358 516.0
TLS1_k127_2028680_0 Cytochrome b subunit of the bc complex K00412 - - 1.756e-253 792.0
TLS1_k127_2028680_1 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 319.0
TLS1_k127_2028680_2 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000005174 134.0
TLS1_k127_2028680_3 zinc finger - - - 0.000000007668 58.0
TLS1_k127_2028680_4 PFAM Rieske 2Fe-2S domain - - - 0.00000004323 62.0
TLS1_k127_205064_0 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 395.0
TLS1_k127_205064_1 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 335.0
TLS1_k127_208659_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01868 - 6.1.1.3 8.106e-247 778.0
TLS1_k127_208659_1 Belongs to the arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004728 367.0
TLS1_k127_208659_2 F5/8 type C domain - - - 0.00000000000000000000000000000000000000000001158 177.0
TLS1_k127_208659_3 - - - - 0.0000000000000000000007656 96.0
TLS1_k127_2088910_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 476.0
TLS1_k127_2088910_1 TIGRFAM excinuclease ABC, C subunit K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000007171 233.0
TLS1_k127_2097962_0 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 342.0
TLS1_k127_2097962_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 340.0
TLS1_k127_2097962_2 PFAM GCN5-related N-acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000000001162 222.0
TLS1_k127_2097962_3 Glyoxalase-like domain K01759 - 4.4.1.5 0.0000000000000000000000000002549 119.0
TLS1_k127_2097962_4 - - - - 0.0000000000000008605 83.0
TLS1_k127_2191120_0 TatD related DNase K07051 - - 0.00000000000000000000000000000000000000000000000000001396 195.0
TLS1_k127_2193793_0 Met-10+ like-protein K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006206 273.0
TLS1_k127_2193793_1 FR47-like protein K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000000000000000000106 268.0
TLS1_k127_2193793_2 HTH DNA binding domain - - - 0.000007018 51.0
TLS1_k127_2232984_0 ribosomal protein L3 K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 424.0
TLS1_k127_2232984_1 Proteasome endopeptidase complex K03432 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007947 411.0
TLS1_k127_2232984_2 Ribosomal protein L4 K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 291.0
TLS1_k127_2232984_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006863 257.0
TLS1_k127_2232984_4 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000005364 218.0
TLS1_k127_2232984_5 Putative RNA methyltransferase K09142 - - 0.000000000000000000000000000000000000000000000000000001209 202.0
TLS1_k127_2232984_6 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000003505 126.0
TLS1_k127_2232984_7 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000000000009522 114.0
TLS1_k127_2265174_0 - - - - 0.0000000000000000000000002033 114.0
TLS1_k127_2265174_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000001709 104.0
TLS1_k127_233413_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 505.0
TLS1_k127_233413_1 Cysteine synthase K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 492.0
TLS1_k127_233413_2 redox protein, regulator of disulfide bond formation - - - 0.00000000008108 62.0
TLS1_k127_2335795_0 TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 511.0
TLS1_k127_2335795_1 PFAM (2R)-phospho-3-sulfolactate synthase ComA K08097 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 4.4.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 434.0
TLS1_k127_2335795_2 - - - - 0.00000000000000000000000001038 115.0
TLS1_k127_2339100_0 TIGRFAM 2-methylcitrate synthase citrate synthase II K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 563.0
TLS1_k127_2339100_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 419.0
TLS1_k127_2339100_2 - - - - 0.0000000000000000000000000000000000000000000286 169.0
TLS1_k127_2339100_3 PUA domain K07575 - - 0.0000000000000000000000000000000000000000006092 165.0
TLS1_k127_2342399_0 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006041 355.0
TLS1_k127_2342399_1 PFAM tRNA synthetase, class II (D, K and N) K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000002856 237.0
TLS1_k127_2357450_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 436.0
TLS1_k127_2357450_1 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000004844 235.0
TLS1_k127_2357450_2 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000006272 148.0
TLS1_k127_2357450_3 Fibronectin type III-like domain K05349 - 3.2.1.21 0.000000000000000000000000008467 110.0
TLS1_k127_2357450_4 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 0.0005102 43.0
TLS1_k127_238843_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1434.0
TLS1_k127_238843_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009749 448.0
TLS1_k127_238843_2 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 374.0
TLS1_k127_238843_3 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.00000002064 58.0
TLS1_k127_2388877_0 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 331.0
TLS1_k127_2417196_0 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000001808 158.0
TLS1_k127_2417196_1 Bacterial Fe(2+) trafficking - - - 0.000000000000000000000000001573 114.0
TLS1_k127_2417196_2 Zinc finger, C2H2 type - - - 0.0000000000001255 72.0
TLS1_k127_2434338_0 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004682 241.0
TLS1_k127_2434338_1 Nudix hydrolase K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000004881 166.0
TLS1_k127_2451735_0 COG0346 Lactoylglutathione lyase and related lyases K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 453.0
TLS1_k127_2451735_1 phospholipase Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001117 250.0
TLS1_k127_2451735_2 sodium:proton antiporter activity K03316 - - 0.0000000000000000000000000000000004636 138.0
TLS1_k127_2451735_4 PFAM Rieske 2Fe-2S domain protein K00363,K05710 - 1.7.1.15 0.000000000000000000004524 96.0
TLS1_k127_2485631_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009344 359.0
TLS1_k127_2485631_1 - - - - 0.00000000000000000000000000003093 119.0
TLS1_k127_2548149_0 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000002382 210.0
TLS1_k127_2548149_1 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000008982 116.0
TLS1_k127_2553613_0 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 352.0
TLS1_k127_2553613_1 response regulator, receiver - - - 0.00000000000000000004592 94.0
TLS1_k127_2579447_0 PFAM tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 495.0
TLS1_k127_2579447_1 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K00363,K15762 - 1.7.1.15 0.0000000000000000000000000000001328 124.0
TLS1_k127_259007_0 PFAM tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 539.0
TLS1_k127_259007_1 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001159 257.0
TLS1_k127_259007_2 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K00363,K15762 - 1.7.1.15 0.000000000000000000000000000000000000000001135 158.0
TLS1_k127_259007_3 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.000000000000000000000000000000000000002179 151.0
TLS1_k127_259007_4 - - - - 0.00000000000002488 79.0
TLS1_k127_2607016_0 Vinylacetyl-CoA Delta-isomerase K14534 - 4.2.1.120,5.3.3.3 3.028e-279 863.0
TLS1_k127_2607016_1 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000001249 59.0
TLS1_k127_2617283_0 Protein of unknown function, DUF255 K06888 - - 9.065e-280 877.0
TLS1_k127_2829314_0 RNase L inhibitor, RLI K06174 - - 2.273e-296 918.0
TLS1_k127_2829314_2 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000006193 77.0
TLS1_k127_2829314_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00001017 47.0
TLS1_k127_2864372_0 including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 361.0
TLS1_k127_2936476_0 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000003111 264.0
TLS1_k127_2936476_2 - - - - 0.000000000000000000000000000005248 126.0
TLS1_k127_2965770_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 447.0
TLS1_k127_2965770_1 Ribosomal protein S30 K02983 - - 0.0000000000000000008615 86.0
TLS1_k127_2983731_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 4.093e-198 627.0
TLS1_k127_2983731_1 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002152 265.0
TLS1_k127_2983731_2 - - - - 0.0000000000000000000000000000000000004086 141.0
TLS1_k127_2983731_3 phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000732 134.0
TLS1_k127_3007762_0 3-isopropylmalate dehydratase, large subunit K01703 - 4.2.1.33,4.2.1.35 9.434e-224 701.0
TLS1_k127_3007762_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 346.0
TLS1_k127_3007762_2 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.0000003075 52.0
TLS1_k127_3071028_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 3.341e-197 623.0
TLS1_k127_3071028_1 COG0433 Predicted ATPase K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 589.0
TLS1_k127_3071028_2 PFAM NurA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001006 258.0
TLS1_k127_3071028_5 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000002063 146.0
TLS1_k127_3071028_6 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000002531 93.0
TLS1_k127_3084940_0 Methionine synthase K00548 - 2.1.1.13 1.7e-321 998.0
TLS1_k127_3084940_1 homocysteine S-methyltransferase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 449.0
TLS1_k127_3089657_0 RNA-metabolising metallo-beta-lactamase K07041 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006693 398.0
TLS1_k127_3089657_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 349.0
TLS1_k127_3103145_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 406.0
TLS1_k127_3103145_1 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 339.0
TLS1_k127_3103145_2 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000008333 64.0
TLS1_k127_3141219_0 Methyltransferase type 11 K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 340.0
TLS1_k127_3141219_1 NADH ubiquinone oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000122 214.0
TLS1_k127_3141219_2 - - - - 0.00000000000000000000000000000000000156 138.0
TLS1_k127_3141219_3 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000002908 72.0
TLS1_k127_3141737_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 0.0 1341.0
TLS1_k127_3141737_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008369 348.0
TLS1_k127_3141737_2 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000001504 141.0
TLS1_k127_3141737_3 - - - - 0.00000000000000000000000000000007613 128.0
TLS1_k127_3156611_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 578.0
TLS1_k127_3156611_1 Predicted membrane protein (DUF2070) K08979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 462.0
TLS1_k127_3156611_2 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000000000002691 182.0
TLS1_k127_3156611_3 Sec61beta family - - - 0.0000000000000000001821 89.0
TLS1_k127_3158482_0 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005816 273.0
TLS1_k127_3158482_1 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000002638 135.0
TLS1_k127_3158482_3 - - - - 0.0001562 45.0
TLS1_k127_3168280_0 ATP synthase (C/AC39) subunit K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 471.0
TLS1_k127_3168280_2 - - - - 0.000000000001202 73.0
TLS1_k127_3175475_0 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000002003 237.0
TLS1_k127_3175475_1 K homology RNA-binding domain K06961 - - 0.000000000000000000000000000000000000000000000000007277 188.0
TLS1_k127_3175475_2 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000000000000001197 120.0
TLS1_k127_3175475_3 pfkB family carbohydrate kinase - - - 0.00000000000001106 76.0
TLS1_k127_3175475_4 Domain of unknown function (DUF373) K08975 - - 0.00002997 47.0
TLS1_k127_31822_0 Succinyl-CoA ligase like flavodoxin domain K18594 - - 0.0 1060.0
TLS1_k127_31822_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 363.0
TLS1_k127_31822_2 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000002452 268.0
TLS1_k127_31822_3 Iron-sulfur cluster assembly accessory protein K13628 - - 0.00000000000000000000000000000000000000000000000000000000000003404 216.0
TLS1_k127_3206428_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 1.14e-285 882.0
TLS1_k127_3264388_0 Thiopurine S-methyltransferase (TPMT) - - - 0.00000000000000000000000000000000000000000000000000000001482 205.0
TLS1_k127_3264388_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000001096 145.0
TLS1_k127_3264388_2 - - - - 0.000000000000000000000716 96.0
TLS1_k127_3280674_0 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005391 316.0
TLS1_k127_3280674_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007898 267.0
TLS1_k127_3294537_0 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 376.0
TLS1_k127_3294537_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000642 339.0
TLS1_k127_3294537_2 tRNA methyl transferase K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 302.0
TLS1_k127_3294537_3 Cysteine desulfurase K04487 - 2.8.1.7 0.000000000000000000000000488 106.0
TLS1_k127_3326850_0 adenylosuccinate lyase K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 604.0
TLS1_k127_3326850_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000001243 142.0
TLS1_k127_3326850_2 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000008356 98.0
TLS1_k127_3350231_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 529.0
TLS1_k127_3350231_1 ThiF family K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000964 427.0
TLS1_k127_3352754_0 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 333.0
TLS1_k127_3352754_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000001162 234.0
TLS1_k127_3383879_0 COG0433 Predicted ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006278 267.0
TLS1_k127_3383879_1 RNA-binding protein contains TRAM domain - - - 0.0000000000000003262 81.0
TLS1_k127_3436368_0 protein (ATP-grasp superfamily) K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 317.0
TLS1_k127_3453382_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001902 277.0
TLS1_k127_3453382_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000001664 223.0
TLS1_k127_3453382_2 response regulator, receiver - - - 0.00000000000000000008626 93.0
TLS1_k127_3472240_0 AhpC/TSA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 397.0
TLS1_k127_3472240_1 geranylgeranyl reductase K17830 - 1.3.1.101,1.3.7.11 0.00009016 44.0
TLS1_k127_3511588_0 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 475.0
TLS1_k127_3511588_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002962 229.0
TLS1_k127_3511588_2 - - - - 0.000000000000000000001549 101.0
TLS1_k127_3511588_3 Aldo/keto reductase family - - - 0.00000000000000000001098 93.0
TLS1_k127_3532970_0 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 343.0
TLS1_k127_3532970_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 289.0
TLS1_k127_3532970_11 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000006976 79.0
TLS1_k127_3532970_2 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 291.0
TLS1_k127_3532970_3 helix_turn_helix ASNC type K03718 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001455 244.0
TLS1_k127_3532970_4 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.000000000000000000000000000000000000000000000000000001646 194.0
TLS1_k127_3532970_5 - - - - 0.0000000000000000000000000000000000000000000000000000214 192.0
TLS1_k127_3532970_6 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.000000000000000000000000000002607 127.0
TLS1_k127_3532970_7 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000004869 122.0
TLS1_k127_3532970_8 - - - - 0.0000000000000000000000000003797 117.0
TLS1_k127_3532970_9 COG2002 Regulators of stationary sporulation gene expression - - - 0.0000000000000000000000004479 107.0
TLS1_k127_3547086_0 PFAM peptidase S1 and S6, chymotrypsin Hap K08070 - 1.3.1.74 0.000000000000000000000000000000000000000000000000000000000000007454 231.0
TLS1_k127_3562266_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 341.0
TLS1_k127_3562266_1 ABC-type transport system, periplasmic component surface lipoprotein K02058,K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000003566 229.0
TLS1_k127_3562266_2 Protein of unknown function (DUF2877) - - - 0.00000003116 65.0
TLS1_k127_3562266_3 Protein of unknown function (DUF1116) K01902,K02381 - 6.2.1.5 0.0001548 46.0
TLS1_k127_3574168_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 405.0
TLS1_k127_3574168_1 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009412 369.0
TLS1_k127_3574168_2 Protein of unknown function (DUF1059) - - - 0.0000002377 54.0
TLS1_k127_3624197_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 3.09e-262 823.0
TLS1_k127_3670224_0 COG2406 Protein distantly related to bacterial ferritins K03594 - 1.16.3.1 0.0000000000000000000000001622 106.0
TLS1_k127_3670224_1 Transcriptional regulator - - - 0.0002197 47.0
TLS1_k127_3694369_0 AAA domain K10742 GO:0000003,GO:0000014,GO:0000166,GO:0000228,GO:0000278,GO:0000706,GO:0000723,GO:0000729,GO:0000733,GO:0000781,GO:0000784,GO:0001302,GO:0003674,GO:0003678,GO:0003682,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006302,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007568,GO:0007569,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009607,GO:0009719,GO:0009987,GO:0016043,GO:0016070,GO:0016233,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016888,GO:0016893,GO:0016895,GO:0017076,GO:0017108,GO:0017111,GO:0019439,GO:0019899,GO:0019900,GO:0019901,GO:0022402,GO:0022414,GO:0022616,GO:0030554,GO:0031297,GO:0031860,GO:0031974,GO:0031981,GO:0032200,GO:0032392,GO:0032502,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0033260,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0035312,GO:0035639,GO:0035861,GO:0036094,GO:0042592,GO:0042623,GO:0043137,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0045005,GO:0045145,GO:0046483,GO:0046700,GO:0048256,GO:0048869,GO:0050896,GO:0051276,GO:0051321,GO:0051716,GO:0060249,GO:0065007,GO:0065008,GO:0070013,GO:0070035,GO:0071103,GO:0071216,GO:0071495,GO:0071704,GO:0071840,GO:0071932,GO:0072396,GO:0072402,GO:0072423,GO:0072429,GO:0090304,GO:0090305,GO:0090734,GO:0097159,GO:0097367,GO:0098687,GO:0140097,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576,GO:1902969,GO:1903046,GO:1903047,GO:1903461,GO:1903469,GO:1990601 3.6.4.12 0.000000001104 70.0
TLS1_k127_3715231_0 LOR SDH bifunctional - - - 6.873e-199 627.0
TLS1_k127_3715231_1 HD domain K07023 - - 0.000000000000000000000000000000000000000000103 166.0
TLS1_k127_3716616_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 509.0
TLS1_k127_3722032_0 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.000000000000000000000000000000000000000000000000000000000000000003476 232.0
TLS1_k127_3722032_1 ribosomal protein K02976 - - 0.000000000000000000000000000000000000000000000007297 172.0
TLS1_k127_3727469_0 Radical SAM K06937 - - 0.0 1092.0
TLS1_k127_3727469_1 Archaeal transcriptional regulator TrmB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 342.0
TLS1_k127_3727469_2 - - - - 0.00000000000000000000000007625 108.0
TLS1_k127_3735588_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006632 250.0
TLS1_k127_3764997_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005408 300.0
TLS1_k127_3764997_1 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000001581 231.0
TLS1_k127_3764997_2 - - - - 0.0000000000000000002644 95.0
TLS1_k127_3783157_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 486.0
TLS1_k127_3869493_0 DNA-directed RNA polymerase, alpha subunit 40 kD subunit K03047 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007614 315.0
TLS1_k127_3869493_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000003228 234.0
TLS1_k127_3869493_2 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000000000008622 232.0
TLS1_k127_3869493_3 Belongs to the eukaryotic ribosomal protein eL18 family K02883 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000004279 112.0
TLS1_k127_3869493_4 - - - - 0.00000000005825 64.0
TLS1_k127_3879369_0 PFAM Coenzyme A transferase K01026 - 2.8.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009291 604.0
TLS1_k127_3879369_1 - - - - 0.0000000000000000000000000000000000781 135.0
TLS1_k127_3879369_2 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000006605 99.0
TLS1_k127_3879369_3 - - - - 0.00001929 46.0
TLS1_k127_3890581_0 RNA-metabolising metallo-beta-lactamase K07041 - - 5.521e-217 684.0
TLS1_k127_3890581_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 345.0
TLS1_k127_3892727_1 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.0000000000000000001292 91.0
TLS1_k127_3915056_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009487 389.0
TLS1_k127_3915056_1 - - - - 0.000000000000000000000000000000000000004214 148.0
TLS1_k127_3949428_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 3.161e-292 919.0
TLS1_k127_4040080_0 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009204 454.0
TLS1_k127_4040080_1 Protein of unknown function (DUF354) K09726 - - 0.00000000000000000000000000000000000000000000000000000000000433 211.0
TLS1_k127_4063461_0 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000001731 184.0
TLS1_k127_4063461_1 Thioredoxin K03671 - - 0.00000000000000001238 84.0
TLS1_k127_4063461_2 peptidase - - - 0.00003087 48.0
TLS1_k127_4080844_0 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.0000000000000000000000000000000000000000000000000000000003106 211.0
TLS1_k127_4080844_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000152 173.0
TLS1_k127_4080844_2 RNA-binding protein contains TRAM domain - - - 0.0000000000000000000000000000000001022 134.0
TLS1_k127_4114310_0 Alpha beta hydrolase K01066,K14731 - 3.1.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 467.0
TLS1_k127_4114310_2 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000002432 186.0
TLS1_k127_4114310_3 CBS domain K03498 - - 0.00000000000000005009 87.0
TLS1_k127_4123346_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 6.307e-238 740.0
TLS1_k127_4123346_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 577.0
TLS1_k127_4124024_0 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 316.0
TLS1_k127_4124024_1 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 310.0
TLS1_k127_4124024_3 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000001307 167.0
TLS1_k127_4128781_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 417.0
TLS1_k127_4128781_1 RNA-metabolising metallo-beta-lactamase K07041 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 296.0
TLS1_k127_4128781_2 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000001418 183.0
TLS1_k127_413669_0 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.000000003744 63.0
TLS1_k127_4156309_0 F5/8 type C domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007103 386.0
TLS1_k127_4156309_1 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000368 203.0
TLS1_k127_4156309_2 ATP-grasp domain - - - 0.00000000000000000000000000000000000001276 158.0
TLS1_k127_4156309_3 WbqC-like protein family - - - 0.0000000000000000000000009503 120.0
TLS1_k127_4156309_4 Histidinol phosphatase and related hydrolases of the PHP family K04477 - - 0.000000005663 66.0
TLS1_k127_4156309_5 Cadherin repeats. - - - 0.00000085 61.0
TLS1_k127_4205802_0 COG1653 ABC-type sugar transport system, periplasmic component K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007579 544.0
TLS1_k127_4205802_1 PFAM ABC transporter related K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 374.0
TLS1_k127_4205802_2 transmembrane transport K02025,K05814,K10109,K10189,K15771,K17245,K17316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 296.0
TLS1_k127_4223908_0 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005564 308.0
TLS1_k127_4223908_1 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000000000000000000000000000000003596 222.0
TLS1_k127_4223908_2 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000001948 76.0
TLS1_k127_4235617_0 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 338.0
TLS1_k127_4235617_1 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050 - - 0.000000000000000000000006579 105.0
TLS1_k127_4259013_0 Electron transfer flavoprotein domain K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 384.0
TLS1_k127_4259013_1 HD domain K00951,K01139 - 2.7.6.5,3.1.7.2 0.00000000000000000000000000000000000000000000000000000000000000000004822 239.0
TLS1_k127_4259013_2 Electron transfer flavoprotein domain K03522 - - 0.00000000000000000000000000000000000000000000001536 174.0
TLS1_k127_4259387_0 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 552.0
TLS1_k127_4264952_0 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 440.0
TLS1_k127_4264952_1 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003868 278.0
TLS1_k127_4264952_2 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000003271 256.0
TLS1_k127_4264952_3 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000001268 79.0
TLS1_k127_4280231_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005565 243.0
TLS1_k127_4280231_1 - - - - 0.00000000000000000000000000000000000000000000001779 175.0
TLS1_k127_4280231_2 - - - - 0.000000000000000000000000000001509 130.0
TLS1_k127_4280231_3 - - - - 0.000000000000000000000000000005664 124.0
TLS1_k127_4280231_4 PFAM regulatory protein, ArsR - - - 0.000002566 51.0
TLS1_k127_4281737_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K15510,K21835 - 1.1.98.2,1.1.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 449.0
TLS1_k127_4281737_1 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000004123 76.0
TLS1_k127_4301358_0 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K01090,K06269 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003838 280.0
TLS1_k127_4301358_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000005777 59.0
TLS1_k127_4301358_2 PFAM GvpD gas vesicle - - - 0.0000005872 61.0
TLS1_k127_4352547_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 552.0
TLS1_k127_4352547_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000002802 214.0
TLS1_k127_4352547_2 4Fe-4S binding domain K00338 - 1.6.5.3 0.00000000000000000005114 91.0
TLS1_k127_4376197_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 450.0
TLS1_k127_4376197_2 Transcriptional regulator - - - 0.000000000000000000003441 100.0
TLS1_k127_4403956_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 457.0
TLS1_k127_4403956_1 FeS assembly ATPase SufC K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008279 421.0
TLS1_k127_4403956_2 Chlorite dismutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 319.0
TLS1_k127_4403956_3 Domain of unknown function (DUF1802) - - - 0.00000000000000000000000000000000000000000000000002715 185.0
TLS1_k127_4417685_0 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000002021 167.0
TLS1_k127_4420754_0 Succinyl-CoA synthetase, alpha subunit K02381 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 420.0
TLS1_k127_4420754_1 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000961 262.0
TLS1_k127_4425081_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005547 492.0
TLS1_k127_4425081_1 PFAM TPR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 323.0
TLS1_k127_4425081_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008741 289.0
TLS1_k127_4425081_3 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001754 264.0
TLS1_k127_4425081_4 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000003937 259.0
TLS1_k127_4425081_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000000000000000000000000000000000000000000000000000008006 219.0
TLS1_k127_4425081_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000001117 218.0
TLS1_k127_4425081_7 ribosomal protein K02976 - - 0.000000000000000000000000000000000000000000000001094 175.0
TLS1_k127_4426096_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1071.0
TLS1_k127_4426096_1 - - - - 0.0000000000000000000000000000000000003631 141.0
TLS1_k127_4446690_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 468.0
TLS1_k127_4446690_1 Belongs to the UPF0284 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005433 381.0
TLS1_k127_4446690_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000543 362.0
TLS1_k127_4446690_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006074 257.0
TLS1_k127_4446690_4 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000001445 248.0
TLS1_k127_4446690_6 Transcriptional regulator - - - 0.000000004486 61.0
TLS1_k127_4465795_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0003674,GO:0003824,GO:0004766,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0050314,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001525 299.0
TLS1_k127_4465795_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000209 117.0
TLS1_k127_4479493_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 552.0
TLS1_k127_4479493_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000004583 247.0
TLS1_k127_4479493_2 response regulator, receiver - - - 0.00000000000000000205 91.0
TLS1_k127_4488568_0 DEAD/H associated K03724 - - 0.0 1095.0
TLS1_k127_4494383_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 8.857e-266 822.0
TLS1_k127_4494383_1 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 2.282e-259 818.0
TLS1_k127_4494383_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 3.476e-238 740.0
TLS1_k127_4494383_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000275 345.0
TLS1_k127_4494383_4 Asp/Glu/Hydantoin racemase K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 312.0
TLS1_k127_4494383_5 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000004318 235.0
TLS1_k127_4494383_6 ATP synthase subunit C K02124 - - 0.000000000000000000000000031 111.0
TLS1_k127_4496021_0 Alpha mannosidase, middle domain K01191 - 3.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005209 527.0
TLS1_k127_4501987_0 Belongs to the complex I 49 kDa subunit family K00333 - 1.6.5.3 1.433e-227 707.0
TLS1_k127_4501987_1 NADH dehydrogenase K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009108 606.0
TLS1_k127_4501987_2 geranylgeranyl reductase K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 471.0
TLS1_k127_4501987_3 Belongs to the complex I 20 kDa subunit family K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 323.0
TLS1_k127_4501987_4 4Fe-4S binding domain K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009486 314.0
TLS1_k127_4501987_5 NADH ubiquinone oxidoreductase 27 kD subunit K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000008414 254.0
TLS1_k127_4501987_6 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3 K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000003678 218.0
TLS1_k127_4501987_7 Universal stress protein - - - 0.0000000000000000000000000614 112.0
TLS1_k127_4503715_0 Large family of predicted nucleotide-binding domains K06865 - - 7.45e-247 776.0
TLS1_k127_4503715_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005973 515.0
TLS1_k127_4503715_2 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 347.0
TLS1_k127_4503715_3 - - - - 0.00000000000000000000000000000000000000000009652 163.0
TLS1_k127_4503715_4 - - - - 0.0000000000000000000002375 103.0
TLS1_k127_4511639_0 Thiamine biosynthesis protein (ThiI) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 427.0
TLS1_k127_4511639_1 RNA-metabolising metallo-beta-lactamase K07041 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004009 251.0
TLS1_k127_4511639_2 Pfam:DUF552 K09152 - - 0.000000000000000000000000000001248 123.0
TLS1_k127_4511639_3 PFAM CBS domain containing protein - - - 0.00000000001879 70.0
TLS1_k127_4522885_0 Subunits I, II and III form the functional core of the enzyme complex K02262 GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902600 - 0.000006361 48.0
TLS1_k127_4560654_0 Belongs to the arginase family K01480 - 3.5.3.11 2.666e-241 746.0
TLS1_k127_4580230_0 Translation initiation factor 2, alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 330.0
TLS1_k127_4580230_1 ATP corrinoid adenosyltransferase K19221 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000008237 243.0
TLS1_k127_4580230_2 Tetrahydromethanopterin S-methyltransferase, subunit A K00577 - 2.1.1.86 0.000000000000000000000000000001841 129.0
TLS1_k127_4580230_3 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000001444 77.0
TLS1_k127_4580230_4 Acetyltransferase (GNAT) domain K00621 - 2.3.1.4 0.00000001026 57.0
TLS1_k127_4607280_0 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000222 282.0
TLS1_k127_4607280_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000008805 225.0
TLS1_k127_4607280_2 Protein of unknown function DUF99 K09120 - - 0.0000000000000000000000000000000000000000000000000002056 191.0
TLS1_k127_4607280_3 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000002514 55.0
TLS1_k127_4618626_0 Belongs to the universal ribosomal protein uS5 family K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 329.0
TLS1_k127_4618626_1 ribosomal protein K02907 - - 0.000000000000000000000000000000000000000000000004435 177.0
TLS1_k127_4618626_2 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000001603 139.0
TLS1_k127_4618626_3 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000006857 53.0
TLS1_k127_4621350_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 0.0 2032.0
TLS1_k127_4621350_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 5.861e-247 765.0
TLS1_k127_4621350_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000000000001004 145.0
TLS1_k127_4635567_0 8-amino-7-oxononanoate synthase K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 391.0
TLS1_k127_4656295_1 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.000000000000000000000000000000000007631 139.0
TLS1_k127_4656295_2 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000009243 106.0
TLS1_k127_4656295_3 ASNC family K03718 - - 0.000000000000000000081 96.0
TLS1_k127_4659361_0 Glycoside hydrolase family 5 - GO:0000322,GO:0000323,GO:0000324,GO:0000329,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005829,GO:0006629,GO:0006706,GO:0008150,GO:0008152,GO:0008202,GO:0008422,GO:0009056,GO:0015926,GO:0016020,GO:0016042,GO:0016134,GO:0016136,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0031090,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0050295,GO:0071704,GO:0098588,GO:0098805,GO:0098852,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901575,GO:1901657,GO:1901658,GO:1901804,GO:1901805,GO:1904461,GO:1904462 - 0.00000000000000000000002207 116.0
TLS1_k127_4659361_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000002967 66.0
TLS1_k127_4659412_0 Major Facilitator Superfamily - - - 1.288e-204 647.0
TLS1_k127_4659412_1 Belongs to the thioredoxin family K03671 - - 0.0000000001 64.0
TLS1_k127_4659412_2 Alkaline phosphatase K01077 - 3.1.3.1 0.0006972 44.0
TLS1_k127_4666237_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1292.0
TLS1_k127_4666237_1 Mannosyl-3-phosphoglycerate synthase K05947 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.217 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 479.0
TLS1_k127_4672712_0 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 477.0
TLS1_k127_4672712_1 Diphthamide biosynthesis K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 458.0
TLS1_k127_4672712_2 PP-loop family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 364.0
TLS1_k127_4672712_3 Domain of unknown function (DUF2024) - - - 0.00000000000000000000000000000000000006601 143.0
TLS1_k127_4672712_4 - - - - 0.0000000000000000000000000000000005323 134.0
TLS1_k127_4672712_5 Protein of unknown function DUF126 K09128 - - 0.0000000000000000000000000000003399 127.0
TLS1_k127_4672712_6 - - - - 0.00000000000000000000002592 100.0
TLS1_k127_4678957_1 PFAM Glycosyl transferases group 1 - - - 0.00000302 56.0
TLS1_k127_4693058_0 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000002425 219.0
TLS1_k127_4693058_1 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.00000000000000000000000000000000004925 139.0
TLS1_k127_4735576_0 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 382.0
TLS1_k127_4735576_1 component I K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 378.0
TLS1_k127_4735576_2 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.000000000000000000000000000000008683 128.0
TLS1_k127_4735576_3 YHS domain - - - 0.0000000000000008905 78.0
TLS1_k127_4735576_4 - - - - 0.0000000001592 63.0
TLS1_k127_4737561_0 CBS domain K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006391 316.0
TLS1_k127_4737561_1 - - - - 0.000000000000000000000006756 109.0
TLS1_k127_4745833_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005347 309.0
TLS1_k127_4745833_1 Zinc finger domain - - - 0.0000000000000000000000000000000000002035 143.0
TLS1_k127_4745833_3 - - - - 0.0000000000005001 74.0
TLS1_k127_4752751_0 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007338 376.0
TLS1_k127_4791298_0 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 395.0
TLS1_k127_4791298_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000002752 211.0
TLS1_k127_4795625_0 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 462.0
TLS1_k127_4795625_1 Lrp/AsnC ligand binding domain K03718 - - 0.00000000000000000000000000000000000000000000000000000000000000000001058 234.0
TLS1_k127_4795625_2 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.000000000000000000000000000000000000000000000000000000000000000001299 229.0
TLS1_k127_4795625_3 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 - 2.1.1.260 0.0000000000000000000000000000000000000000000000000000005295 202.0
TLS1_k127_4795625_4 Belongs to the PDCD5 family K06875 - - 0.000000000000000000000000000007249 121.0
TLS1_k127_4795625_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.000000000000000000000001212 106.0
TLS1_k127_4795625_6 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.000002602 49.0
TLS1_k127_4818133_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 3.758e-230 730.0
TLS1_k127_4823466_0 methanogenesis marker protein 1 K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 524.0
TLS1_k127_4823466_1 PFAM TfuA domain protein, core - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009826 253.0
TLS1_k127_4828247_0 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007002 276.0
TLS1_k127_4828247_1 - - - - 0.00000000000000000000000000000000000000000000001092 180.0
TLS1_k127_4828247_2 endonuclease activity - - - 0.0002688 44.0
TLS1_k127_4829652_0 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006214 516.0
TLS1_k127_4829652_1 Deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000000000000000000001133 111.0
TLS1_k127_4829652_2 BON domain - - - 0.000004527 53.0
TLS1_k127_484100_0 PFAM aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 511.0
TLS1_k127_484100_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 322.0
TLS1_k127_484100_2 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000003335 228.0
TLS1_k127_484100_3 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000004977 211.0
TLS1_k127_487885_0 Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine K05831 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 526.0
TLS1_k127_487885_1 HMGL-like K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008126 483.0
TLS1_k127_487885_2 Lysine biosynthesis K05827 - 6.3.2.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006996 397.0
TLS1_k127_487885_3 diphthine synthase K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 386.0
TLS1_k127_487885_4 lysine biosynthesis protein LysW K05826 - - 0.000000000000000000000002017 102.0
TLS1_k127_4907682_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 546.0
TLS1_k127_4907682_1 PFAM Like-Sm ribonucleoprotein, core - - - 0.0000000000000000000000000000000000000000000000000000000000002021 214.0
TLS1_k127_4908887_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001044 280.0
TLS1_k127_4946473_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000828 256.0
TLS1_k127_4946988_0 component I K01657 - 4.1.3.27 0.00000000000000000000000000000000000004982 148.0
TLS1_k127_4946988_1 MOFRL family K11529 - 2.7.1.165 0.00000004563 59.0
TLS1_k127_4976383_0 Cobalamin B12-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001881 269.0
TLS1_k127_4976383_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000001087 224.0
TLS1_k127_4985251_0 SMC proteins Flexible Hinge Domain K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 640.0
TLS1_k127_4987084_0 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008612 596.0
TLS1_k127_4987084_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003859 556.0
TLS1_k127_4987084_2 Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) K05828 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007352 364.0
TLS1_k127_4987084_3 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000001148 256.0
TLS1_k127_4987084_4 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000001138 141.0
TLS1_k127_4988198_0 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 370.0
TLS1_k127_4988198_1 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000002185 216.0
TLS1_k127_4992506_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 538.0
TLS1_k127_4992506_2 - - - - 0.0000000000000006226 83.0
TLS1_k127_4992506_3 Transcriptional regulator - - - 0.00000000006253 67.0
TLS1_k127_5017246_0 COG1653 ABC-type sugar transport system, periplasmic component K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 569.0
TLS1_k127_5017246_1 Universal stress protein - - - 0.00000000000000000000000008748 112.0
TLS1_k127_5017246_2 Sodium/hydrogen exchanger family K03316 - - 0.000000000000006469 79.0
TLS1_k127_5051004_0 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000002111 238.0
TLS1_k127_5051004_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000001775 227.0
TLS1_k127_5051004_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000002301 126.0
TLS1_k127_5051004_3 Belongs to the eIF-2B alpha beta delta subunits family - - - 0.00000000000000000000000004831 112.0
TLS1_k127_5079464_0 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 1.366e-199 626.0
TLS1_k127_5079464_1 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 370.0
TLS1_k127_5079464_2 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001013 282.0
TLS1_k127_5122071_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 395.0
TLS1_k127_5122071_1 - - - - 0.00000000000000000000000000000000001254 142.0
TLS1_k127_5122071_2 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000004558 145.0
TLS1_k127_5129732_0 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000714 289.0
TLS1_k127_5129732_1 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000003253 206.0
TLS1_k127_5130369_0 Phenylalanyl-tRNA synthetase alpha subunit K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 488.0
TLS1_k127_5130369_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01867 - 6.1.1.2 0.000000000003529 68.0
TLS1_k127_513405_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 466.0
TLS1_k127_513405_1 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000774 333.0
TLS1_k127_513405_3 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000001444 77.0
TLS1_k127_513405_4 alginic acid biosynthetic process K09483 - 4.2.1.118 0.000000000832 68.0
TLS1_k127_5167251_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K20989 - - 4.532e-298 932.0
TLS1_k127_5167251_1 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 375.0
TLS1_k127_5167251_2 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 282.0
TLS1_k127_5167251_3 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001168 257.0
TLS1_k127_5167251_4 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000006538 83.0
TLS1_k127_5184822_0 Ammonium Transporter K03320 - - 1.613e-207 651.0
TLS1_k127_5184822_1 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000002828 177.0
TLS1_k127_5184822_2 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000005083 165.0
TLS1_k127_528572_0 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 413.0
TLS1_k127_528572_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000001457 173.0
TLS1_k127_528572_2 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.00000000000000000005727 93.0
TLS1_k127_528572_3 - - - - 0.00000000000000008255 80.0
TLS1_k127_532011_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1231.0
TLS1_k127_532011_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 296.0
TLS1_k127_5324689_0 hydroxymethylglutaryl-CoA reductase (NADPH) activity K00021 - 1.1.1.34 0.0 1072.0
TLS1_k127_5324689_1 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001123 247.0
TLS1_k127_5324689_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000001716 177.0
TLS1_k127_5338709_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.495e-199 631.0
TLS1_k127_5338709_1 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 482.0
TLS1_k127_5338709_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 376.0
TLS1_k127_5338709_3 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 349.0
TLS1_k127_5338709_4 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 340.0
TLS1_k127_5338709_5 Amino acid kinase family K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000001026 244.0
TLS1_k127_5338709_6 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000002994 195.0
TLS1_k127_5344855_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 351.0
TLS1_k127_5344855_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 312.0
TLS1_k127_5344855_2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000003778 56.0
TLS1_k127_5400301_0 Radical SAM - - - 4.114e-313 962.0
TLS1_k127_5400301_1 oxidoreductase FAD NAD(P)-binding K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007455 329.0
TLS1_k127_5400301_2 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000009201 198.0
TLS1_k127_5400301_3 - - - - 0.000000000000000000000000000000000000000000002136 166.0
TLS1_k127_5400301_4 Circadian clock protein KaiC - - - 0.0000000000001367 80.0
TLS1_k127_5444383_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 594.0
TLS1_k127_5444383_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 417.0
TLS1_k127_5444383_2 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000001651 112.0
TLS1_k127_5463724_0 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 587.0
TLS1_k127_5463724_1 DEAD DEAH box helicase K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 541.0
TLS1_k127_5463724_2 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 0.00000000000000000000005661 99.0
TLS1_k127_5463724_3 PFAM malic K00027 - 1.1.1.38 0.0000000002613 61.0
TLS1_k127_5463724_4 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 0.000000001394 62.0
TLS1_k127_5463724_5 COG0281 Malic enzyme K00029 - 1.1.1.40 0.000001045 50.0
TLS1_k127_5463724_6 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 0.0001086 45.0
TLS1_k127_5482555_0 Sodium:solute symporter family - - - 3.564e-249 777.0
TLS1_k127_5482555_1 PFAM TCP-1 cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 312.0
TLS1_k127_5501652_0 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 424.0
TLS1_k127_5501652_1 Xylose isomerase-like TIM barrel K18910 - 5.1.3.30,5.1.3.31 0.0000000000000000000000000000000198 137.0
TLS1_k127_5501652_2 Methyltransferase - - - 0.00000001484 57.0
TLS1_k127_5506861_0 Carbamoyl-phosphate synthase L chain K18603 - 6.4.1.2,6.4.1.3 3.055e-209 658.0
TLS1_k127_5506861_1 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000005503 219.0
TLS1_k127_5506861_2 biotin carboxyl carrier K00627,K01571,K15037,K18605 - 2.3.1.12,4.1.1.3 0.00000000000000000000000000000000000000000000001598 178.0
TLS1_k127_5512763_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 1.097e-244 764.0
TLS1_k127_5518660_0 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001105 279.0
TLS1_k127_5518660_1 Queuosine biosynthesis protein QueC K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000436 250.0
TLS1_k127_5518660_2 Belongs to the class-I aminoacyl-tRNA synthetase family - - - 0.000000000000000000000000000000000002944 138.0
TLS1_k127_5518660_3 - - - - 0.000000000000000000002852 99.0
TLS1_k127_5528792_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.285e-265 826.0
TLS1_k127_5528792_1 GTPase of unknown function C-terminal K06942 - - 0.000000000000000000000000000000000000000000008262 163.0
TLS1_k127_5528792_2 HIT domain K02503 - - 0.000000000000000000000000000000000000000005867 158.0
TLS1_k127_5539877_0 - - - - 0.0000000000000000000000000000000000000003541 164.0
TLS1_k127_5561692_0 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 321.0
TLS1_k127_5561692_1 Binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000000000000000000000000000001225 229.0
TLS1_k127_5561692_2 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.000000000000000000000000000000003092 132.0
TLS1_k127_5580157_0 Belongs to the MCM family K10726 - - 5.898e-216 676.0
TLS1_k127_5582369_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 392.0
TLS1_k127_5582369_1 RNA methylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009128 293.0
TLS1_k127_5582369_2 RibD C-terminal domain K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000004192 237.0
TLS1_k127_5600387_0 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001324 247.0
TLS1_k127_5600983_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006643 326.0
TLS1_k127_5610597_0 TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 - 2.6.1.16 1.232e-226 716.0
TLS1_k127_5610597_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 3.197e-217 683.0
TLS1_k127_5610597_2 PFAM S-layer - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 396.0
TLS1_k127_5610597_3 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000000000000007017 231.0
TLS1_k127_5610597_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000001855 215.0
TLS1_k127_5610597_5 Translin family K07477 - - 0.00000000000000000000000000000000000000000000000000000002287 203.0
TLS1_k127_5610597_6 Belongs to the UPF0147 family K09721 - - 0.00000000006757 65.0
TLS1_k127_5632564_0 MGS-like domain K01955 - 6.3.5.5 4.424e-205 645.0
TLS1_k127_5632564_1 Calcineurin-like phosphoesterase K06953 - - 0.000000000000000000000000000000000000000000000000000002976 199.0
TLS1_k127_5634893_0 ABC1 family - - - 2.873e-208 660.0
TLS1_k127_5634893_1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000002065 143.0
TLS1_k127_5634893_2 - - - - 0.00000000000000000000000000003749 121.0
TLS1_k127_5634893_3 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000007237 116.0
TLS1_k127_5634893_4 Kinase binding protein CGI-121 - - - 0.0000000000000000000023 102.0
TLS1_k127_5634893_5 ribosomal protein K02962 - - 0.0000000000000000002326 90.0
TLS1_k127_5634893_6 Kinase binding protein CGI-121 - - - 0.000000000000009605 77.0
TLS1_k127_5634893_7 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000005772 51.0
TLS1_k127_5636351_0 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 4.678e-275 856.0
TLS1_k127_5636351_1 Peptidase family M3 K08602 - - 4.428e-233 735.0
TLS1_k127_5636351_2 Belongs to the MCM family K10726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001774 268.0
TLS1_k127_5636351_3 GINS complex protein K09723 - - 0.000000000000000000000000000000000000000000000000000003819 196.0
TLS1_k127_5665412_0 High-affinity Fe2 Pb2 permease K07243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 610.0
TLS1_k127_5665412_1 COG1653 ABC-type sugar transport system, periplasmic component K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 295.0
TLS1_k127_5665412_2 - - - - 0.00000000000000000000000000000000000008001 145.0
TLS1_k127_5665412_3 DNA binding K09191 GO:0000182,GO:0000976,GO:0000992,GO:0001002,GO:0001016,GO:0001025,GO:0001030,GO:0001067,GO:0001156,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005700,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006351,GO:0006355,GO:0006383,GO:0006725,GO:0006807,GO:0007049,GO:0008134,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009303,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022402,GO:0031323,GO:0031326,GO:0031490,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042023,GO:0042791,GO:0043035,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0044786,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0060968,GO:0065007,GO:0071704,GO:0080084,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098781,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.0008731 44.0
TLS1_k127_5665563_0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000002799 119.0
TLS1_k127_5665563_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.000000000000000000002735 102.0
TLS1_k127_5682615_0 COG0346 Lactoylglutathione lyase and related lyases K15975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 455.0
TLS1_k127_5682615_1 phospholipase Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000001525 165.0
TLS1_k127_5682615_2 Rieske 2Fe-2S K05710 - - 0.00001506 47.0
TLS1_k127_5686268_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 379.0
TLS1_k127_5686268_1 DNA primase K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005424 266.0
TLS1_k127_5686268_2 Toprim domain - - - 0.00000000000000000000000000000000000001071 151.0
TLS1_k127_5686268_3 mttA/Hcf106 family K03116 - - 0.0000000000000005187 82.0
TLS1_k127_5699053_0 Fumarase C C-terminus K01744 - 4.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 580.0
TLS1_k127_5699053_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.00000000000000000000000000000000000000000000000000000000001045 212.0
TLS1_k127_5699053_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.00000000000000000000000000000000000000000000000000005944 193.0
TLS1_k127_5699053_3 Peptidyl-tRNA hydrolase PTH2 K04794 - 3.1.1.29 0.000000000000000000000000000000000000013 149.0
TLS1_k127_5699053_4 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.0000000000000000000000000000001123 123.0
TLS1_k127_5699053_5 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000000000000003394 107.0
TLS1_k127_5711776_1 Belongs to the TrpA family K01695,K13222 - 4.1.2.8,4.2.1.20 0.00003749 48.0
TLS1_k127_5817962_0 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000136 287.0
TLS1_k127_5817962_1 - - - - 0.000000000000000000000000000000000000000000000000000006818 198.0
TLS1_k127_5817962_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000001285 154.0
TLS1_k127_5845621_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 6.078e-200 629.0
TLS1_k127_5845621_1 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001548 275.0
TLS1_k127_5845621_2 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.00000000000000000000000000000000000001955 146.0
TLS1_k127_5845621_3 - - - - 0.0000000000000000000002477 96.0
TLS1_k127_5845621_4 - - - - 0.00000004774 55.0
TLS1_k127_5854154_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 - - 4.502e-241 749.0
TLS1_k127_5854154_1 DNA polymerase K02319 - 2.7.7.7 4.331e-206 653.0
TLS1_k127_5854154_2 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000008317 195.0
TLS1_k127_5854154_3 - - - - 0.0000000000000000000000004881 108.0
TLS1_k127_5854154_4 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.00002507 46.0
TLS1_k127_5859068_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 453.0
TLS1_k127_5859068_1 PFAM Integral membrane protein TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 359.0
TLS1_k127_5980059_0 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 306.0
TLS1_k127_5980059_1 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000001237 172.0
TLS1_k127_5980059_2 - - - - 0.00000000000000000002344 98.0
TLS1_k127_6001537_0 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000000001499 150.0
TLS1_k127_6001537_2 - - - - 0.000000002465 63.0
TLS1_k127_6001537_3 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0001561 44.0
TLS1_k127_6019010_1 - - - - 0.00000000000000000000000000000000001434 139.0
TLS1_k127_6019010_2 Universal stress protein - - - 0.000000000000000000000009019 107.0
TLS1_k127_6019010_4 RNA-binding protein contains TRAM domain - - - 0.00000000000000007318 83.0
TLS1_k127_6019010_5 CBS domain - - - 0.000000001107 65.0
TLS1_k127_6019010_6 COG0517 FOG CBS domain - - - 0.0001026 48.0
TLS1_k127_6030050_0 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000002075 221.0
TLS1_k127_6030050_1 - - - - 0.00000000000000001564 84.0
TLS1_k127_6030050_2 PFAM transcriptional regulator PadR family protein - - - 0.0000000000000002246 82.0
TLS1_k127_6049505_0 phosphatase homologous to the C-terminal domain of histone macroH2A1 K07478 - - 0.000000000000000000000000000000000000001081 152.0
TLS1_k127_6049505_1 O-methyltransferase - - - 0.000000000000000002491 90.0
TLS1_k127_6049505_2 Appr-1'-p processing enzyme - - - 0.0000007376 54.0
TLS1_k127_6116911_0 Amino acid kinase family K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000005975 264.0
TLS1_k127_6116911_1 - - - - 0.0009137 51.0
TLS1_k127_6128125_0 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 334.0
TLS1_k127_6128125_1 SMC proteins Flexible Hinge Domain K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000914 275.0
TLS1_k127_615866_0 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 299.0
TLS1_k127_615866_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.000000000000000000000000000000000000000000000000000000000452 203.0
TLS1_k127_615866_2 RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000000000000006332 141.0
TLS1_k127_615866_3 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000109 138.0
TLS1_k127_615866_4 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000003059 65.0
TLS1_k127_6160639_0 MGS-like domain K01955 - 6.3.5.5 6.454e-251 790.0
TLS1_k127_6171656_0 Arsenite-activated ATPase ArsA K01551,K13993 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 442.0
TLS1_k127_6171656_1 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 440.0
TLS1_k127_6171656_2 Ribbon-helix-helix protein, copG family K07722 - - 0.0000000000000000000000000000000000000000000000007384 177.0
TLS1_k127_6171656_3 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.00000000000000000000000000000000000000000000001926 173.0
TLS1_k127_6171656_4 - - - - 0.00000000000001087 75.0
TLS1_k127_6228368_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 9.36e-267 839.0
TLS1_k127_6269600_0 Type III restriction enzyme, res subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 552.0
TLS1_k127_6345903_0 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 428.0
TLS1_k127_6345903_1 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000004292 237.0
TLS1_k127_6345903_2 - - - - 0.000000000000000000000000000000007265 130.0
TLS1_k127_6345903_3 Transcriptional regulator - - - 0.0000000006938 64.0
TLS1_k127_6345903_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0001746 44.0
TLS1_k127_6369146_0 HMGL-like K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 467.0
TLS1_k127_6369146_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 370.0
TLS1_k127_6369146_2 COG1522 Transcriptional regulators - - - 0.00000000000001171 79.0
TLS1_k127_6369774_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 573.0
TLS1_k127_6369774_1 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 431.0
TLS1_k127_6369774_2 acetolactate synthase, small K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000001952 247.0
TLS1_k127_6371020_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.301e-296 923.0
TLS1_k127_6371020_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 3.399e-293 912.0
TLS1_k127_6412523_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016427,GO:0016428,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 325.0
TLS1_k127_6412523_1 - - - - 0.00000000000000000000000000000000000000000000000000000002335 203.0
TLS1_k127_6412523_2 Ribosome biogenesis protein, C-terminal K09140 - - 0.000000000000000000000007059 103.0
TLS1_k127_6412523_3 Protein involved in ribosomal biogenesis, contains PUA domain K07565 - - 0.000000000000000002533 93.0
TLS1_k127_6462361_0 PFAM regulatory protein, ArsR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 481.0
TLS1_k127_6462361_1 - - - - 0.00000000000000000000000000000000000000001455 161.0
TLS1_k127_6462361_2 ferredoxin - - - 0.00000000000000000000000001033 108.0
TLS1_k127_6500646_0 Formyl transferase K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 407.0
TLS1_k127_6500646_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009665 275.0
TLS1_k127_6500646_2 snRNP Sm proteins K04796 - - 0.000000000000000000000000000000000000004873 146.0
TLS1_k127_6500646_3 Binds to the 23S rRNA K02922 - - 0.00000000000000000000000003385 108.0
TLS1_k127_6500646_5 - - - - 0.00000000007246 70.0
TLS1_k127_6546933_0 Sulfite reductase K00392 - 1.8.7.1 1.568e-258 805.0
TLS1_k127_6546933_1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004606 504.0
TLS1_k127_6641124_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008237 533.0
TLS1_k127_6641124_1 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 473.0
TLS1_k127_6641124_2 regulatory protein, arsR - - - 0.00000000000000000002656 93.0
TLS1_k127_6663755_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 462.0
TLS1_k127_6663755_1 Cytidylyltransferase-like K02201 - 2.7.7.3 0.00000000000000000000000000000000000000000001876 166.0
TLS1_k127_6663755_2 ferredoxin - - - 0.00000000000000000000000001033 108.0
TLS1_k127_6687770_0 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 1.125e-213 681.0
TLS1_k127_6687770_1 conserved protein implicated in secretion - - - 0.0000000000000003587 82.0
TLS1_k127_6690554_0 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 3.14e-305 942.0
TLS1_k127_6690554_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 381.0
TLS1_k127_6690554_2 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 372.0
TLS1_k127_6690554_3 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003927 240.0
TLS1_k127_6690554_4 Iron-sulfur cluster assembly protein - - - 0.0000000000000000000000000000000000000000000000004308 177.0
TLS1_k127_6690554_5 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.0000000000000000000000000000000000000001497 152.0
TLS1_k127_66915_0 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 429.0
TLS1_k127_66915_1 SRP19 protein K03105 - - 0.00000000000000000000000000000000002338 137.0
TLS1_k127_66915_2 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000006431 132.0
TLS1_k127_66915_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000016 86.0
TLS1_k127_6703508_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 413.0
TLS1_k127_6703508_1 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008292 293.0
TLS1_k127_6703508_2 PFAM Methyltransferase type K15256 - - 0.00000000000000000000000000000000002056 143.0
TLS1_k127_6703508_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.000000000000000000004472 96.0
TLS1_k127_6733678_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000003995 242.0
TLS1_k127_6733678_1 Transcriptional regulator - - - 0.00000001045 59.0
TLS1_k127_684059_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006535 591.0
TLS1_k127_684059_1 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001782 269.0
TLS1_k127_684059_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008007 265.0
TLS1_k127_684059_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000000000000000000000000000000000000494 203.0
TLS1_k127_684059_4 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000001415 122.0
TLS1_k127_6882542_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 449.0
TLS1_k127_6882542_1 Glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000002028 266.0
TLS1_k127_6882542_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000001679 171.0
TLS1_k127_6891675_0 thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 329.0
TLS1_k127_6891675_1 thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009483 322.0
TLS1_k127_6891675_2 SnoaL-like polyketide cyclase - - - 0.000000000000006979 80.0
TLS1_k127_7002383_0 Succinyl-CoA ligase like flavodoxin domain K18593 - - 3.286e-248 778.0
TLS1_k127_7093203_0 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.0000000000000000000000000000000000000000000000000000000000000000000000000004694 265.0
TLS1_k127_7093203_1 Ion transport protein K10716 GO:0003674,GO:0005215,GO:0005216,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022832,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 0.000000002373 67.0
TLS1_k127_7110249_0 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000000000000000000006536 146.0
TLS1_k127_7110249_1 protein conserved in archaea K09723 - - 0.000000000000000000000000000000000125 140.0
TLS1_k127_7110249_2 - - - - 0.000000000000000000001171 97.0
TLS1_k127_7124911_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 3.189e-267 836.0
TLS1_k127_7124911_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 3.521e-199 625.0
TLS1_k127_714038_0 FAD linked - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 424.0
TLS1_k127_714038_1 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 288.0
TLS1_k127_714038_2 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000002958 181.0
TLS1_k127_7169134_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 476.0
TLS1_k127_7169134_1 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000289 239.0
TLS1_k127_7175005_0 DNA methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 494.0
TLS1_k127_7175005_1 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 395.0
TLS1_k127_7175005_2 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000008325 195.0
TLS1_k127_7175005_3 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000004066 177.0
TLS1_k127_7277412_0 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005925 270.0
TLS1_k127_7277412_1 - - - - 0.0000000000000000000000000000000000000000000000001594 179.0
TLS1_k127_7277412_2 Glyoxalase-like domain K01759 - 4.4.1.5 0.00000000000000000000000000000000000000002455 156.0
TLS1_k127_7308639_0 Translation initiation factor K03238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001995 243.0
TLS1_k127_7308639_1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000000000000002365 192.0
TLS1_k127_7321770_0 response regulator, receiver - - - 0.00000000000000000000000008083 112.0
TLS1_k127_7371940_0 Luciferase-like monooxygenase K14728 - - 4.528e-205 640.0
TLS1_k127_7371940_1 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006424 470.0
TLS1_k127_7371940_2 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000522 340.0
TLS1_k127_7371940_3 Transcriptional regulator K07108 - - 0.0000000000000000000000000000000000000000000000000000003349 198.0
TLS1_k127_7371940_4 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000008548 177.0
TLS1_k127_7437158_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 551.0
TLS1_k127_7437158_1 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002306 276.0
TLS1_k127_7437158_2 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000002339 139.0
TLS1_k127_7437158_3 - - - - 0.00000000000000000002025 93.0
TLS1_k127_7437158_5 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.000000037 61.0
TLS1_k127_7445388_0 Cytosolic purine - - - 0.0000001465 53.0
TLS1_k127_7445388_3 Leucine rich repeat N-terminal domain - - - 0.0006343 43.0
TLS1_k127_7470042_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 3.673e-213 674.0
TLS1_k127_7470042_1 SMART Elongator protein 3 MiaB NifB K07739 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005746 436.0
TLS1_k127_7470042_2 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 354.0
TLS1_k127_7470042_4 HD domain K00951,K01139 - 2.7.6.5,3.1.7.2 0.00000000000000006062 83.0
TLS1_k127_7502106_0 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 363.0
TLS1_k127_7502106_1 RNase H K03469 - 3.1.26.4 0.0000000000000000000000000000000008355 133.0
TLS1_k127_7510238_0 Phosphoglycolate phosphatase K22223 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009475 280.0
TLS1_k127_7510238_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000000000001876 226.0
TLS1_k127_7510238_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00001242 49.0
TLS1_k127_7558560_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 394.0
TLS1_k127_7558560_1 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000008703 195.0
TLS1_k127_7558560_2 NUDIX domain - - - 0.000000000000000000000000000000000000005524 149.0
TLS1_k127_7558560_3 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000002702 146.0
TLS1_k127_7558560_4 - - - - 0.00000000000000000004505 91.0
TLS1_k127_755993_0 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 327.0
TLS1_k127_755993_1 beta-glucosidase activity K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000003467 238.0
TLS1_k127_7570965_0 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 566.0
TLS1_k127_7570965_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 420.0
TLS1_k127_7570965_2 Belongs to the peptidase M24B family K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005909 340.0
TLS1_k127_7570965_3 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 321.0
TLS1_k127_7570965_4 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 314.0
TLS1_k127_7570965_5 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001948 281.0
TLS1_k127_7570965_6 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000734 259.0
TLS1_k127_7570965_7 Phosphate uptake regulator - - - 0.00000000000000000000000000000001187 130.0
TLS1_k127_7570965_8 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000672 94.0
TLS1_k127_757113_0 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 480.0
TLS1_k127_7591489_0 - - - - 0.000000000000000000000000000000000000000000004717 171.0
TLS1_k127_7591489_1 - - - - 0.0000000000000000000000000000000000000001737 150.0
TLS1_k127_7591489_2 - - - - 0.00000000000000000000000000000002275 138.0
TLS1_k127_7591489_4 - - - - 0.0000000000000001336 79.0
TLS1_k127_7592490_0 PAC2 family K06869 - - 0.00000000000000000000000000000000000005775 147.0
TLS1_k127_7592490_1 PAC2 family K06869 - - 0.0000000000144 67.0
TLS1_k127_7596183_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 547.0
TLS1_k127_7596183_1 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 310.0
TLS1_k127_7596183_2 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000445 224.0
TLS1_k127_7596183_3 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000002154 88.0
TLS1_k127_7596183_4 Belongs to the UPF0218 family K09735 - - 0.00000000000000007232 87.0
TLS1_k127_7614089_0 Initiation factor K03242 - - 1.303e-218 684.0
TLS1_k127_7614089_1 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 375.0
TLS1_k127_7614089_2 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007174 263.0
TLS1_k127_7619181_0 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 326.0
TLS1_k127_7619181_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009733 243.0
TLS1_k127_7619181_2 ERCC4 domain K10848 - - 0.000000000000000000000000000000000000000000000000000000000000000004548 234.0
TLS1_k127_7619181_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000000000000003161 173.0
TLS1_k127_7619181_4 - - - - 0.00000000000000000000000000000005455 130.0
TLS1_k127_7619181_5 Ribosomal L37ae protein family K02921 - - 0.0000000000000000000000001495 106.0
TLS1_k127_7619181_6 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000001452 90.0
TLS1_k127_7620377_0 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 8.838e-240 747.0
TLS1_k127_7620377_1 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 548.0
TLS1_k127_7620377_2 Radical SAM K18285 - 2.5.1.120 0.00009243 46.0
TLS1_k127_7628121_0 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 332.0
TLS1_k127_7628121_1 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007504 352.0
TLS1_k127_7628488_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 352.0
TLS1_k127_7628488_1 - - - - 0.00000000000000000000000000000005312 127.0
TLS1_k127_7651443_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1407.0
TLS1_k127_7651443_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 334.0
TLS1_k127_7651443_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001316 258.0
TLS1_k127_7651443_3 Participates in transcription termination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000003221 226.0
TLS1_k127_7651443_4 - - - - 0.00000000000000000000000000000000354 131.0
TLS1_k127_7651443_5 structural constituent of ribosome K02908 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000007741 57.0
TLS1_k127_7711729_0 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 1.952e-199 628.0
TLS1_k127_7711729_1 Methyltransferase type 11 K03183 - 2.1.1.163,2.1.1.201 0.0000002356 53.0
TLS1_k127_7770635_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 453.0
TLS1_k127_7770635_1 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000000000000000001898 203.0
TLS1_k127_7795867_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008958 497.0
TLS1_k127_7795867_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000004152 195.0
TLS1_k127_7830653_0 phosphohistidine phosphatase, SixA K08296 - - 0.0000000000000000000000000000000000000001907 154.0
TLS1_k127_7830653_1 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000007615 134.0
TLS1_k127_7830653_2 - - - - 0.000000003612 61.0
TLS1_k127_7837464_0 HAD-superfamily phosphatase, subfamily IIIC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 291.0
TLS1_k127_7837464_1 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000003684 115.0
TLS1_k127_7837464_2 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.00000004076 57.0
TLS1_k127_7853048_0 S-adenosylmethionine synthetase K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 612.0
TLS1_k127_7853048_1 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 285.0
TLS1_k127_7853048_2 snRNP Sm proteins K04796 - - 0.0000000000000000000000000000000001032 134.0
TLS1_k127_7853048_3 dUTPase - - - 0.0000000000000000000000000000000008743 133.0
TLS1_k127_7869252_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 497.0
TLS1_k127_7869252_1 resolvase K14060 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 303.0
TLS1_k127_7869252_2 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000000000000000000000000002955 180.0
TLS1_k127_7884647_0 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 383.0
TLS1_k127_7884647_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007691 336.0
TLS1_k127_791629_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 6.541e-232 723.0
TLS1_k127_7952207_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004321 590.0
TLS1_k127_7952207_1 Tyrosine--tRNA ligase K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 476.0
TLS1_k127_7952207_2 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934 - 2.1.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 421.0
TLS1_k127_7954620_0 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007548 381.0
TLS1_k127_7954620_1 Conserved hypothetical ATP binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000005622 218.0
TLS1_k127_7954620_2 - - - - 0.00000000000000000000000000000000000000000007966 164.0
TLS1_k127_7954620_3 - - - - 0.000000000000000000000001389 104.0
TLS1_k127_7959253_0 Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000000000000002335 189.0
TLS1_k127_7959253_2 Hexapeptide repeat of succinyl-transferase K04042 - 2.3.1.157,2.7.7.23 0.000003812 51.0
TLS1_k127_7965394_0 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 480.0
TLS1_k127_7965394_1 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 460.0
TLS1_k127_7965394_2 PFAM blue (type 1) copper domain protein - - - 0.00000008725 61.0
TLS1_k127_7980367_0 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 1.89e-272 852.0
TLS1_k127_7980367_1 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004584 485.0
TLS1_k127_7980367_2 TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate family K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007787 398.0
TLS1_k127_7980367_3 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000001442 234.0
TLS1_k127_7980367_4 Archaeal ammonia monooxygenase subunit A (AmoA) K10944 - 1.14.18.3,1.14.99.39 0.0000000000000000001524 87.0
TLS1_k127_8004689_0 DEAD DEAH box helicase K06877 - - 0.0 1102.0
TLS1_k127_8015549_0 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 396.0
TLS1_k127_8015549_1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) K05967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003206 248.0
TLS1_k127_8015549_2 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.00000000000000000000000000000000000000008597 156.0
TLS1_k127_8045199_0 Amino acid kinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008571 519.0
TLS1_k127_8045199_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 365.0
TLS1_k127_8072166_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 437.0
TLS1_k127_8072166_1 Oxidoreductase family, NAD-binding Rossmann fold K18855 - 1.1.1.374 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 360.0
TLS1_k127_8072166_2 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 284.0
TLS1_k127_8072166_3 Nicotinamide-nucleotide adenylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002506 238.0
TLS1_k127_8072166_4 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000000000000000000000002468 163.0
TLS1_k127_866413_0 - - - - 0.0000000000000000000000000003233 116.0
TLS1_k127_866413_1 Transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.00000000000000004652 93.0
TLS1_k127_866413_2 transferase K00997 - 2.7.8.7 0.0000000000000001933 83.0
TLS1_k127_883331_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 4.534e-276 859.0
TLS1_k127_883331_1 Thioredoxin K03671 - - 0.00000000000000000000000000000000000000000000000000000000002176 207.0
TLS1_k127_883331_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000001945 188.0
TLS1_k127_883331_3 Binds to the 23S rRNA K02896 - - 0.00000000000000000002147 90.0
TLS1_k127_883331_4 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.00000000000000002124 85.0
TLS1_k127_919841_0 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.21.7 0.0000000000000000000000000000000000000000002293 166.0
TLS1_k127_919841_1 endonuclease K00986 - 2.7.7.49 0.0000000000000000003346 90.0
TLS1_k127_919841_2 Ion channel K00564,K10716 - 2.1.1.172 0.00000005498 61.0
TLS1_k127_966934_0 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003462 273.0
TLS1_k127_966934_1 PFAM Methyltransferase type K15256 - - 0.0000000000000000000000000003684 117.0
TLS1_k127_994140_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 331.0
TLS1_k127_994140_1 Transcriptional regulator - - - 0.000000000000000002614 91.0