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Overview

ID MAG03985
Name TLS2_bin.16
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Terriglobia
Order Terriglobales
Family JAFAIN01
Genus
Species
Assembly information
Completeness (%) 95.81
Contamination (%) 0.21
GC content (%) 67.0
N50 (bp) 18,392
Genome size (bp) 3,114,298

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2682

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1014560_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1344.0
TLS2_k127_1014560_1 Belongs to the ClpA ClpB family K03696 - - 0.0 1328.0
TLS2_k127_1014560_10 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 523.0
TLS2_k127_1014560_11 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007544 487.0
TLS2_k127_1014560_12 iron ion homeostasis K05349 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 512.0
TLS2_k127_1014560_13 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 407.0
TLS2_k127_1014560_14 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 326.0
TLS2_k127_1014560_15 gluconolactonase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 334.0
TLS2_k127_1014560_16 ZIP Zinc transporter K07238,K16267 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006766 302.0
TLS2_k127_1014560_17 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004895 280.0
TLS2_k127_1014560_18 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007814 279.0
TLS2_k127_1014560_19 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007436 266.0
TLS2_k127_1014560_2 COG3209 Rhs family protein - - - 9.523e-261 826.0
TLS2_k127_1014560_20 COG2818 3-methyladenine DNA glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000001116 261.0
TLS2_k127_1014560_21 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002209 250.0
TLS2_k127_1014560_22 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000004971 236.0
TLS2_k127_1014560_23 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000007815 194.0
TLS2_k127_1014560_24 NUDIX domain - - - 0.00000000000000000000000000000000000000000000001609 174.0
TLS2_k127_1014560_25 methyltransferase activity K00587 - 2.1.1.100 0.00000000000000000000000000000000000006442 150.0
TLS2_k127_1014560_27 Forkhead associated domain - - - 0.000000000000000000000000000000000007782 149.0
TLS2_k127_1014560_28 Domain of unknown function (DUF4149) - - - 0.000000000000000000000000000000000009812 141.0
TLS2_k127_1014560_29 PFAM S23 ribosomal protein - - - 0.000000000000000000000000000000002982 139.0
TLS2_k127_1014560_3 SpoIVB peptidase S55 - - - 1.544e-259 813.0
TLS2_k127_1014560_30 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000006688 108.0
TLS2_k127_1014560_31 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000002946 93.0
TLS2_k127_1014560_32 - - - - 0.000000000000004926 86.0
TLS2_k127_1014560_33 - - - - 0.00000000002465 74.0
TLS2_k127_1014560_34 SNARE associated Golgi protein - - - 0.00000000003861 64.0
TLS2_k127_1014560_36 Belongs to the peptidase M48B family K03799 - - 0.0000000009374 59.0
TLS2_k127_1014560_37 glyoxalase III activity - - - 0.00001359 48.0
TLS2_k127_1014560_4 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 8.97e-255 810.0
TLS2_k127_1014560_5 DNA ligase D, 3'-phosphoesterase domain K01971 - 6.5.1.1 1.881e-228 724.0
TLS2_k127_1014560_6 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 3.999e-198 627.0
TLS2_k127_1014560_8 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 559.0
TLS2_k127_1014560_9 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007808 528.0
TLS2_k127_1017372_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.985e-229 720.0
TLS2_k127_1017372_1 Pyridoxal-dependent decarboxylase conserved domain - - - 3.649e-196 623.0
TLS2_k127_1017372_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 627.0
TLS2_k127_1017372_3 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 375.0
TLS2_k127_1017372_4 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000007966 164.0
TLS2_k127_1017372_5 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000000002189 91.0
TLS2_k127_1019537_0 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.0 1120.0
TLS2_k127_1019537_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0 1047.0
TLS2_k127_1019537_10 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 611.0
TLS2_k127_1019537_11 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008453 556.0
TLS2_k127_1019537_12 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 554.0
TLS2_k127_1019537_13 argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 522.0
TLS2_k127_1019537_14 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008975 489.0
TLS2_k127_1019537_15 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 489.0
TLS2_k127_1019537_16 MoeZ MoeB K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 471.0
TLS2_k127_1019537_17 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 470.0
TLS2_k127_1019537_18 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005131 450.0
TLS2_k127_1019537_19 Asparaginase K01444 - 3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 446.0
TLS2_k127_1019537_2 Ftsk_gamma K03466 - - 1.935e-301 944.0
TLS2_k127_1019537_20 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 436.0
TLS2_k127_1019537_21 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 420.0
TLS2_k127_1019537_22 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 403.0
TLS2_k127_1019537_23 Short chain fatty acid transporter K02106 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 395.0
TLS2_k127_1019537_24 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009705 385.0
TLS2_k127_1019537_25 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007167 379.0
TLS2_k127_1019537_26 Sel1-like repeats. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 379.0
TLS2_k127_1019537_27 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 374.0
TLS2_k127_1019537_28 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 362.0
TLS2_k127_1019537_29 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 375.0
TLS2_k127_1019537_3 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 1.124e-287 898.0
TLS2_k127_1019537_30 translation release factor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 366.0
TLS2_k127_1019537_31 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 370.0
TLS2_k127_1019537_32 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006016 367.0
TLS2_k127_1019537_33 galactose-1-phosphate K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 355.0
TLS2_k127_1019537_34 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000735 351.0
TLS2_k127_1019537_35 PFAM Peptidase M16 inactive domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 323.0
TLS2_k127_1019537_36 molybdate abc transporter K02018,K15496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 310.0
TLS2_k127_1019537_37 PFAM MCP methyltransferase, CheR-type K00575,K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 327.0
TLS2_k127_1019537_38 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 310.0
TLS2_k127_1019537_39 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 310.0
TLS2_k127_1019537_4 surface antigen variable number - - - 1.422e-273 875.0
TLS2_k127_1019537_40 TOBE domain K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 310.0
TLS2_k127_1019537_41 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 293.0
TLS2_k127_1019537_42 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 289.0
TLS2_k127_1019537_43 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007021 293.0
TLS2_k127_1019537_44 PAS domain containing protein K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001496 306.0
TLS2_k127_1019537_45 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002815 267.0
TLS2_k127_1019537_46 Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006879 271.0
TLS2_k127_1019537_47 Dihydrodipicolinate reductase, C-terminus K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000002661 259.0
TLS2_k127_1019537_48 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000008499 256.0
TLS2_k127_1019537_49 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005997 250.0
TLS2_k127_1019537_5 PFAM TonB-dependent Receptor - - - 3.922e-243 776.0
TLS2_k127_1019537_50 Bacitracin resistance protein BacA K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000003758 246.0
TLS2_k127_1019537_51 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007308 259.0
TLS2_k127_1019537_52 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000003387 251.0
TLS2_k127_1019537_53 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001312 232.0
TLS2_k127_1019537_54 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000001166 233.0
TLS2_k127_1019537_56 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000008291 238.0
TLS2_k127_1019537_57 - - - - 0.00000000000000000000000000000000000000000000000000000000005481 215.0
TLS2_k127_1019537_58 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000005902 218.0
TLS2_k127_1019537_59 Disulphide isomerase - - - 0.000000000000000000000000000000000000000000000000000005074 194.0
TLS2_k127_1019537_6 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 1.605e-217 679.0
TLS2_k127_1019537_60 Acetyltransferase (GNAT) family K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000001142 186.0
TLS2_k127_1019537_61 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000008169 189.0
TLS2_k127_1019537_62 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000002752 194.0
TLS2_k127_1019537_63 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000001646 182.0
TLS2_k127_1019537_64 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000000000000000000000000001021 152.0
TLS2_k127_1019537_65 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000002063 149.0
TLS2_k127_1019537_66 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - 0.000000000000000000000000000000000001081 150.0
TLS2_k127_1019537_67 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000003163 152.0
TLS2_k127_1019537_68 GGDEF domain K13590 - 2.7.7.65 0.000000000000000000000000000000000005796 149.0
TLS2_k127_1019537_69 - - - - 0.0000000000000000000000000000000007687 137.0
TLS2_k127_1019537_7 Elongator protein 3, MiaB family, Radical SAM - - - 5.884e-201 631.0
TLS2_k127_1019537_70 Peptidase M56 - - - 0.000000000000000000000000000000003298 141.0
TLS2_k127_1019537_71 Universal stress protein family - - - 0.000000000000000000000000000000003357 132.0
TLS2_k127_1019537_72 EAL domain - - - 0.0000000000000000000000000000007374 135.0
TLS2_k127_1019537_73 - - - - 0.000000000000000000000000000004871 124.0
TLS2_k127_1019537_74 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.000000000000000000000000001101 120.0
TLS2_k127_1019537_75 - - - - 0.00000000000000000000000002303 109.0
TLS2_k127_1019537_76 cheY-homologous receiver domain - - - 0.00000000000000000000000002415 123.0
TLS2_k127_1019537_78 Cold shock protein domain K03704 - - 0.0000000000000000000000002005 109.0
TLS2_k127_1019537_79 cheY-homologous receiver domain - - - 0.00000000000000000000002478 106.0
TLS2_k127_1019537_8 Arginosuccinate synthase K01940 - 6.3.4.5 4.603e-199 627.0
TLS2_k127_1019537_80 PspC domain K03973 - - 0.000000000000000001156 90.0
TLS2_k127_1019537_82 Bacterial regulatory protein, Fis family K07713 - - 0.00000000000004463 76.0
TLS2_k127_1019537_84 Putative adhesin - - - 0.000672 51.0
TLS2_k127_1019537_9 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 612.0
TLS2_k127_1075624_0 N-terminal domain of (some) glycogen debranching enzymes - - - 0.0 1026.0
TLS2_k127_1075624_1 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 7.819e-233 735.0
TLS2_k127_1075624_10 - - - - 0.00000000000000000000000002298 114.0
TLS2_k127_1075624_11 - - - - 0.0000000007165 60.0
TLS2_k127_1075624_2 von Willebrand factor (vWF) type A domain K07114 - - 2.036e-218 682.0
TLS2_k127_1075624_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 493.0
TLS2_k127_1075624_4 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 443.0
TLS2_k127_1075624_5 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 441.0
TLS2_k127_1075624_6 Bacterial regulatory protein, Fis family K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000002962 229.0
TLS2_k127_1075624_7 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000001533 201.0
TLS2_k127_1075624_8 ATP-dependent protease La (LON) substrate-binding domain - - - 0.0000000000000000000000000000000000000000003484 166.0
TLS2_k127_1075624_9 PFAM Iron sulphur-containing domain, CDGSH-type - - - 0.00000000000000000000000000000001312 130.0
TLS2_k127_1078332_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1529.0
TLS2_k127_1078332_1 Alpha-amylase domain K05341,K05343 - 2.4.1.4,3.2.1.1,5.4.99.16 0.0 1467.0
TLS2_k127_1078332_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000006704 49.0
TLS2_k127_1088930_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.515e-302 941.0
TLS2_k127_1088930_1 antiporter K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001313 260.0
TLS2_k127_1119712_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 572.0
TLS2_k127_1119712_1 excinuclease ABC activity - - - 0.0000000000000000000000000000009519 126.0
TLS2_k127_1119712_2 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000001024 117.0
TLS2_k127_1132995_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 2.138e-277 874.0
TLS2_k127_1132995_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - - 2.031e-203 640.0
TLS2_k127_1132995_10 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.0000000000000000000000000000001562 128.0
TLS2_k127_1132995_11 Septum formation initiator K05589 - - 0.00000000000000000002747 98.0
TLS2_k127_1132995_12 - - - - 0.00000001821 61.0
TLS2_k127_1132995_2 Belongs to the allantoicase family K01477 - 3.5.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 559.0
TLS2_k127_1132995_3 Amidohydrolase family K01466 - 3.5.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 546.0
TLS2_k127_1132995_4 Belongs to the HpcH HpaI aldolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 506.0
TLS2_k127_1132995_5 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001787 286.0
TLS2_k127_1132995_6 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000007388 259.0
TLS2_k127_1132995_7 2 iron, 2 sulfur cluster binding K03518,K07302 - 1.2.5.3,1.3.99.16 0.0000000000000000000000000000000000000000000000000000000006734 205.0
TLS2_k127_1132995_8 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000001826 186.0
TLS2_k127_1132995_9 Potential Queuosine, Q, salvage protein family - - - 0.00000000000000000000000000000000000000000007519 174.0
TLS2_k127_1134093_0 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 366.0
TLS2_k127_1134093_1 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000001055 221.0
TLS2_k127_1134093_2 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000002548 215.0
TLS2_k127_1137017_0 ABC transporter K11085 - - 1.871e-244 767.0
TLS2_k127_1137017_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 452.0
TLS2_k127_1137017_2 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 355.0
TLS2_k127_1137017_3 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000001027 252.0
TLS2_k127_1137017_4 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000005235 92.0
TLS2_k127_1140382_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.0 1021.0
TLS2_k127_1140382_1 Delta-1-pyrroline-5-carboxylate dehydrogenase K00294 - 1.2.1.88 5.812e-248 772.0
TLS2_k127_1140382_10 Membrane-bound lysozyme-inhibitor of c-type lysozyme - - - 0.000000000000000000000364 101.0
TLS2_k127_1140382_11 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000004557 100.0
TLS2_k127_1140382_12 - - - - 0.00000001073 60.0
TLS2_k127_1140382_13 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000002922 62.0
TLS2_k127_1140382_2 COG0534 Na -driven multidrug efflux pump K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 446.0
TLS2_k127_1140382_3 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004899 424.0
TLS2_k127_1140382_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000005842 233.0
TLS2_k127_1140382_5 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000002345 233.0
TLS2_k127_1140382_6 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000002503 205.0
TLS2_k127_1140382_7 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000269 207.0
TLS2_k127_1140382_8 COG0590 Cytosine adenosine deaminases K01485 - 3.5.4.1 0.00000000000000000000000000000000000000000000000000000008012 199.0
TLS2_k127_1140382_9 - - - - 0.00000000000000000000000000000000000000000000002023 175.0
TLS2_k127_1175356_0 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008083 286.0
TLS2_k127_1194746_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 6.11e-203 653.0
TLS2_k127_1194746_1 TIGRFAM Outer membrane assembly lipoprotein YfiO K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006636 370.0
TLS2_k127_1194746_2 ABC transporter K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 356.0
TLS2_k127_1194746_3 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 323.0
TLS2_k127_1194746_4 - - - - 0.0000000000000000000000000000000000000000000000000000000001166 218.0
TLS2_k127_1194746_5 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000001835 181.0
TLS2_k127_1194746_6 type VI secretion system K06887,K11903 - - 0.000002806 58.0
TLS2_k127_123216_0 Mur ligase middle domain K02558 - 6.3.2.45 4.686e-200 638.0
TLS2_k127_123216_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 587.0
TLS2_k127_123216_10 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000002417 258.0
TLS2_k127_123216_11 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002021 256.0
TLS2_k127_123216_12 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000006731 231.0
TLS2_k127_123216_13 MgtC family K07507 - - 0.00000000000000000000000000000000000000000000000000000000000001332 223.0
TLS2_k127_123216_14 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000000005139 223.0
TLS2_k127_123216_15 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000006558 209.0
TLS2_k127_123216_16 Protein of unknown function (DUF1761) - - - 0.00000000000000000000000000000000000000000000002892 176.0
TLS2_k127_123216_17 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.0000000000000000000000000000000000000000000009862 175.0
TLS2_k127_123216_18 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000003147 167.0
TLS2_k127_123216_19 antisigma factor binding K04749 - - 0.0000000000000000000000000000000000001269 148.0
TLS2_k127_123216_2 DEAD DEAH box helicase K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007925 476.0
TLS2_k127_123216_20 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000002242 137.0
TLS2_k127_123216_21 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K16079 - - 0.00000000000000000000000039 113.0
TLS2_k127_123216_23 multi-organism process - - - 0.00007745 55.0
TLS2_k127_123216_3 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 426.0
TLS2_k127_123216_4 acid phosphatase activity K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 437.0
TLS2_k127_123216_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 383.0
TLS2_k127_123216_6 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 323.0
TLS2_k127_123216_7 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 298.0
TLS2_k127_123216_8 LD-carboxypeptidase K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008886 298.0
TLS2_k127_123216_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005155 282.0
TLS2_k127_1255646_0 membrane organization K07277,K09800 - - 0.0 1431.0
TLS2_k127_1255646_1 Carboxypeptidase regulatory-like domain - - - 3.366e-252 799.0
TLS2_k127_1255646_10 Pfam:N_methyl_2 - - - 0.000001583 59.0
TLS2_k127_1255646_11 Pilus assembly protein PilX K02673 - - 0.00004871 56.0
TLS2_k127_1255646_3 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004331 262.0
TLS2_k127_1255646_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000006779 235.0
TLS2_k127_1255646_5 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000009058 230.0
TLS2_k127_1255646_6 PFAM Histidine triad (HIT) protein K02503 - - 0.00000000000000000000000000000000000000000000000009333 187.0
TLS2_k127_1255646_9 Type II transport protein GspH K08084 - - 0.0000009138 59.0
TLS2_k127_1257223_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 3e-323 1013.0
TLS2_k127_1257223_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.002e-272 848.0
TLS2_k127_1257223_10 iron ion homeostasis K05349 - 3.2.1.21 0.000000000000000000009368 107.0
TLS2_k127_1257223_11 - - - - 0.0000000000000000185 90.0
TLS2_k127_1257223_12 pfam yhs - - - 0.0000001897 60.0
TLS2_k127_1257223_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 1.674e-219 698.0
TLS2_k127_1257223_3 PFAM short chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 435.0
TLS2_k127_1257223_4 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 425.0
TLS2_k127_1257223_5 Gram-negative bacterial TonB protein C-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007712 265.0
TLS2_k127_1257223_6 - - - - 0.0000000000000000000000000000000000000000000000000001988 193.0
TLS2_k127_1257223_7 Uncharacterized protein conserved in bacteria (DUF2199) - - - 0.000000000000000000000000000000000000000000006241 173.0
TLS2_k127_1257223_8 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000001199 154.0
TLS2_k127_1257223_9 TIGRFAM LPPG domain protein containing protein K11212 - 2.7.8.28 0.000000000000000000000000000000000001895 145.0
TLS2_k127_1258826_0 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 377.0
TLS2_k127_1258826_1 serine-type peptidase activity K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005618 362.0
TLS2_k127_1258826_2 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 314.0
TLS2_k127_1258826_3 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000118 282.0
TLS2_k127_1258826_4 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002663 284.0
TLS2_k127_1276565_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 4.941e-204 645.0
TLS2_k127_1276565_1 Disulphide bond corrector protein DsbC K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 613.0
TLS2_k127_1276565_10 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 346.0
TLS2_k127_1276565_11 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001349 258.0
TLS2_k127_1276565_12 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000008582 233.0
TLS2_k127_1276565_13 cytochrome c nitrite reductase K15876 - - 0.000000000000000000000000000000000000000000000000000000000003782 214.0
TLS2_k127_1276565_14 - - - - 0.0000000000000000000000000000000000000000000000000000000006236 226.0
TLS2_k127_1276565_15 Anabaena sensory rhodopsin transducer - - - 0.0000000000000000000000000000000000000000000000000000000008098 204.0
TLS2_k127_1276565_16 RDD family - - - 0.000000000000000000000000000000000000000000000001492 183.0
TLS2_k127_1276565_17 VIT family - - - 0.0000000000000000000000000000000009479 141.0
TLS2_k127_1276565_18 SNARE associated Golgi protein - - - 0.0000000000000000000000000000002098 131.0
TLS2_k127_1276565_19 Cold shock protein domain K03704 - - 0.00000000000000000000000000000192 120.0
TLS2_k127_1276565_2 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 574.0
TLS2_k127_1276565_20 - - - - 0.00000000000000000000000000002475 130.0
TLS2_k127_1276565_21 Domain of unknown function (DUF4129) - - - 0.000000000000000000000159 113.0
TLS2_k127_1276565_23 Belongs to the UPF0312 family - - - 0.00000000001008 74.0
TLS2_k127_1276565_24 - - - - 0.00004097 53.0
TLS2_k127_1276565_3 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 505.0
TLS2_k127_1276565_4 COGs COG1620 L-lactate permease K03303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 503.0
TLS2_k127_1276565_5 PFAM LmbE family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005906 524.0
TLS2_k127_1276565_6 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000716 401.0
TLS2_k127_1276565_7 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007679 400.0
TLS2_k127_1276565_8 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 400.0
TLS2_k127_1276565_9 Membrane K06384 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000558 335.0
TLS2_k127_1277620_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 2.86e-259 825.0
TLS2_k127_1277620_1 dioxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 392.0
TLS2_k127_1277620_2 Alginate export - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 404.0
TLS2_k127_1277620_3 iron ion homeostasis K05349 - 3.2.1.21 0.0000000000000000000000000000000000000009823 169.0
TLS2_k127_1277620_4 - - - - 0.0000000004693 61.0
TLS2_k127_1289944_0 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.0 1182.0
TLS2_k127_1289944_1 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 436.0
TLS2_k127_1289944_10 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000001926 190.0
TLS2_k127_1289944_2 glucose sorbosone K00117,K21430 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 436.0
TLS2_k127_1289944_3 lipoprotein localization to outer membrane K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 427.0
TLS2_k127_1289944_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 367.0
TLS2_k127_1289944_5 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 340.0
TLS2_k127_1289944_6 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 338.0
TLS2_k127_1289944_7 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 317.0
TLS2_k127_1289944_8 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009863 267.0
TLS2_k127_1289944_9 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000002171 209.0
TLS2_k127_129372_0 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 482.0
TLS2_k127_129372_1 Thioesterase superfamily - - - 0.00000000000000000000000000000000001096 138.0
TLS2_k127_1304093_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K09181 - - 0.0 1150.0
TLS2_k127_1304093_1 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1028.0
TLS2_k127_1304093_10 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 613.0
TLS2_k127_1304093_11 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004548 598.0
TLS2_k127_1304093_12 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 595.0
TLS2_k127_1304093_13 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 574.0
TLS2_k127_1304093_14 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 584.0
TLS2_k127_1304093_15 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 597.0
TLS2_k127_1304093_16 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 569.0
TLS2_k127_1304093_17 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 582.0
TLS2_k127_1304093_18 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 487.0
TLS2_k127_1304093_19 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 473.0
TLS2_k127_1304093_2 4 iron, 4 sulfur cluster binding K03737 - 1.2.7.1 7.143e-238 776.0
TLS2_k127_1304093_20 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008148 419.0
TLS2_k127_1304093_21 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 414.0
TLS2_k127_1304093_22 Cytochrome c554 and c-prime K03620 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 377.0
TLS2_k127_1304093_23 Ferric reductase like transmembrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009843 372.0
TLS2_k127_1304093_24 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 366.0
TLS2_k127_1304093_25 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 337.0
TLS2_k127_1304093_26 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009252 326.0
TLS2_k127_1304093_27 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 318.0
TLS2_k127_1304093_28 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778 - 1.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004191 314.0
TLS2_k127_1304093_29 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000315 284.0
TLS2_k127_1304093_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.804e-229 715.0
TLS2_k127_1304093_30 cyclic nucleotide-binding K01420,K10914 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001165 276.0
TLS2_k127_1304093_31 cyclic nucleotide-binding K01420,K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000969 263.0
TLS2_k127_1304093_32 membrane protein, hemolysin III homolog K11068 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000002059 242.0
TLS2_k127_1304093_33 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002864 233.0
TLS2_k127_1304093_34 Zn peptidase - - - 0.000000000000000000000000000000000000000000000000000000000005251 228.0
TLS2_k127_1304093_35 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000000000000000000000000000000000000006067 208.0
TLS2_k127_1304093_36 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000000004269 204.0
TLS2_k127_1304093_37 cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000002297 192.0
TLS2_k127_1304093_38 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.00000000000000000000000000000000000000000001244 170.0
TLS2_k127_1304093_4 MacB-like periplasmic core domain - - - 6.315e-207 670.0
TLS2_k127_1304093_40 - - - - 0.000000000000000000000000000000000009808 150.0
TLS2_k127_1304093_41 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000003056 134.0
TLS2_k127_1304093_42 Universal stress protein - - - 0.0000000000000000000000000000002444 135.0
TLS2_k127_1304093_43 OsmC-like protein - - - 0.000000000000000000000000000001239 127.0
TLS2_k127_1304093_45 cyclic nucleotide-binding K01420,K10914 - - 0.0000000000000000001034 95.0
TLS2_k127_1304093_46 - - - - 0.000000000000000001563 89.0
TLS2_k127_1304093_47 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000001626 89.0
TLS2_k127_1304093_48 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000001359 84.0
TLS2_k127_1304093_49 - - - - 0.000002317 53.0
TLS2_k127_1304093_5 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 8.661e-204 639.0
TLS2_k127_1304093_6 efflux transmembrane transporter activity K02004 - - 2.313e-197 646.0
TLS2_k127_1304093_7 Prokaryotic cytochrome b561 - - - 2.804e-195 629.0
TLS2_k127_1304093_8 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 632.0
TLS2_k127_1304093_9 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007959 615.0
TLS2_k127_1321154_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 1.447e-267 830.0
TLS2_k127_1321154_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 9.59e-206 647.0
TLS2_k127_1321154_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 409.0
TLS2_k127_1321154_3 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000000000001783 186.0
TLS2_k127_1325489_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 9.846e-244 764.0
TLS2_k127_1325489_1 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 608.0
TLS2_k127_1325489_2 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 289.0
TLS2_k127_1325489_3 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000002267 136.0
TLS2_k127_1326439_0 PFAM Prolyl oligopeptidase family - - - 1.181e-283 884.0
TLS2_k127_1326439_1 sh3 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 383.0
TLS2_k127_1326439_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000003288 201.0
TLS2_k127_1326439_3 Frataxin-like domain K06202 - - 0.00000000000000000000000000000000002621 146.0
TLS2_k127_1326439_4 von Willebrand factor, type A - - - 0.00004851 50.0
TLS2_k127_1398203_0 virulence factor MVIN family protein K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003747 606.0
TLS2_k127_1398203_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000001113 258.0
TLS2_k127_1398203_2 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000000000000000000002649 219.0
TLS2_k127_1398203_3 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000001334 132.0
TLS2_k127_1398203_4 carboxymuconolactone decarboxylase - - - 0.00000000000000000000000001262 112.0
TLS2_k127_1398203_5 - - - - 0.000002709 52.0
TLS2_k127_1398203_6 carboxymuconolactone decarboxylase K07486 - - 0.00002815 49.0
TLS2_k127_143481_0 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.0 1045.0
TLS2_k127_143481_1 Pfam:DUF2305 - - - 0.000000000000000000000000000000000000000000000000000000000000000000176 238.0
TLS2_k127_143481_2 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.00001427 48.0
TLS2_k127_1468567_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.465e-319 987.0
TLS2_k127_1468567_1 PFAM Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009792 498.0
TLS2_k127_1468567_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 361.0
TLS2_k127_1468567_3 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001246 240.0
TLS2_k127_1468567_4 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8 0.000000000000000000000000000000000000000000000000000005511 197.0
TLS2_k127_1468567_5 - - - - 0.0000000000000000007959 95.0
TLS2_k127_1503153_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1049.0
TLS2_k127_1503153_1 PFAM Radical SAM - - - 5.789e-230 722.0
TLS2_k127_1503153_2 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006703 388.0
TLS2_k127_1510101_0 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 386.0
TLS2_k127_1510101_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000003824 218.0
TLS2_k127_1510101_2 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000009915 193.0
TLS2_k127_1510564_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 455.0
TLS2_k127_1510564_1 Cysteine-rich domain K11473 - - 0.000000000000000000000000000000000000000000000106 172.0
TLS2_k127_1510564_2 ACT domain protein - - - 0.0000000000000002878 83.0
TLS2_k127_1581692_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 1.196e-209 656.0
TLS2_k127_1581692_1 NADH dehydrogenase K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 585.0
TLS2_k127_1581692_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000008884 83.0
TLS2_k127_1608270_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 2.501e-229 744.0
TLS2_k127_1608270_1 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000001163 207.0
TLS2_k127_1608270_2 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000000009412 180.0
TLS2_k127_1608270_3 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000000000000001539 118.0
TLS2_k127_1608270_4 - - - - 0.0000000000000002823 86.0
TLS2_k127_1608270_5 - - - - 0.000000003717 58.0
TLS2_k127_1708663_0 PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 0.0 1165.0
TLS2_k127_1708663_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 1.557e-250 789.0
TLS2_k127_1708663_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000003677 220.0
TLS2_k127_1708663_11 plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000000001642 195.0
TLS2_k127_1708663_12 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000188 166.0
TLS2_k127_1708663_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000002391 164.0
TLS2_k127_1708663_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000000001059 146.0
TLS2_k127_1708663_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.049e-239 745.0
TLS2_k127_1708663_3 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 7.135e-229 717.0
TLS2_k127_1708663_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 4.45e-210 659.0
TLS2_k127_1708663_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 554.0
TLS2_k127_1708663_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 426.0
TLS2_k127_1708663_7 Amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001769 278.0
TLS2_k127_1708663_8 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006273 271.0
TLS2_k127_1708663_9 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000002897 249.0
TLS2_k127_1719114_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003777 539.0
TLS2_k127_1719114_1 4Fe-4S dicluster domain K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 395.0
TLS2_k127_1719114_2 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000004588 199.0
TLS2_k127_1719114_3 FR47-like protein K18816 - 2.3.1.82 0.000000000000000000000000000000000134 138.0
TLS2_k127_1731080_0 G-rich domain on putative tyrosine kinase K08252,K16554 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 606.0
TLS2_k127_1731080_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 565.0
TLS2_k127_1731080_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 437.0
TLS2_k127_1731080_3 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 399.0
TLS2_k127_1731080_4 Serine aminopeptidase, S33 K18457 - 3.5.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 346.0
TLS2_k127_1731080_5 -O-antigen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004353 278.0
TLS2_k127_1731080_6 TonB C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002677 259.0
TLS2_k127_1731080_7 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000002193 241.0
TLS2_k127_1731080_8 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000168 47.0
TLS2_k127_1731080_9 Tetratricopeptide TPR_2 repeat protein - - - 0.00003851 56.0
TLS2_k127_173676_0 Peptidase M14, carboxypeptidase A - - - 7.657e-250 796.0
TLS2_k127_173676_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000001682 96.0
TLS2_k127_173676_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000002441 58.0
TLS2_k127_175814_0 COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 300.0
TLS2_k127_175814_1 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006996 293.0
TLS2_k127_175814_2 PFAM GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000001281 231.0
TLS2_k127_175814_3 Male sterility protein K01784 - 5.1.3.2 0.0000000000000000003432 89.0
TLS2_k127_1758262_0 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 4.733e-243 769.0
TLS2_k127_1758262_1 PFAM amidohydrolase K01464 - 3.5.2.2 3.146e-200 634.0
TLS2_k127_1758262_10 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000000000000000000000000767 149.0
TLS2_k127_1758262_11 TIGRFAM phosphate phosphite phosphonate ABC transporters, periplasmic binding protein K02044 - - 0.0000000000000000000000000000008191 134.0
TLS2_k127_1758262_12 Reverse transcriptase-like K03469 - 3.1.26.4 0.0000000000000000000001166 102.0
TLS2_k127_1758262_13 thiolester hydrolase activity K07000 - - 0.0000000000000001248 94.0
TLS2_k127_1758262_2 PFAM Permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 616.0
TLS2_k127_1758262_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K15372 - 2.6.1.19,2.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007562 561.0
TLS2_k127_1758262_4 Belongs to the aldehyde dehydrogenase family K00141,K22187 - 1.2.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 499.0
TLS2_k127_1758262_5 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 468.0
TLS2_k127_1758262_6 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 402.0
TLS2_k127_1758262_7 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004762 265.0
TLS2_k127_1758262_8 MafB19-like deaminase K01487 - 3.5.4.3 0.000000000000000000000000000000000000000000000000000000001906 203.0
TLS2_k127_1758262_9 Binding-protein-dependent transport system inner membrane component K02042 - - 0.0000000000000000000000000000000000000000000000232 182.0
TLS2_k127_1768700_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 569.0
TLS2_k127_1768700_1 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006548 486.0
TLS2_k127_1768700_2 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 312.0
TLS2_k127_1768700_3 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002199 265.0
TLS2_k127_1768700_4 (Rhomboid) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003108 247.0
TLS2_k127_1768700_5 small multidrug export protein - - - 0.00000000000000000000000000000000000000000000000008556 181.0
TLS2_k127_1768700_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.000000000000000000000000000000000002944 138.0
TLS2_k127_1768700_7 - - - - 0.000002126 54.0
TLS2_k127_1789413_0 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 1.297e-213 684.0
TLS2_k127_1789413_1 cell shape determining protein MreB K03569 - - 3.333e-209 654.0
TLS2_k127_1789413_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 500.0
TLS2_k127_1789413_3 PFAM FecR protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006028 437.0
TLS2_k127_1789413_4 Rod shape-determining protein MreC K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 302.0
TLS2_k127_1789413_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008574 272.0
TLS2_k127_1789413_6 shape-determining protein MreD K03571 - - 0.0000000000000000000000000000000000000000000000000000007225 203.0
TLS2_k127_1789413_7 PFAM RNA-binding protein AU-1 Ribonuclease E G K08301 - - 0.00000000000000000000000000000000000000000061 175.0
TLS2_k127_1789413_8 Phosphoesterase family K01114 - 3.1.4.3 0.0000000002437 73.0
TLS2_k127_1815159_0 TIGRFAM Malto-oligosyltrehalose synthase K06044 - 5.4.99.15 0.0 1163.0
TLS2_k127_1815159_1 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 599.0
TLS2_k127_1815159_10 - - - - 0.000000000000000002619 100.0
TLS2_k127_1815159_11 hemerythrin HHE cation binding domain - - - 0.00000000000000000823 91.0
TLS2_k127_1815159_12 TIGRFAM TonB K03832 - - 0.00000000000000009698 95.0
TLS2_k127_1815159_13 transcription factor binding K03406,K10125,K13924,K21084 - 2.1.1.80,2.7.13.3,2.7.7.65,3.1.1.61 0.000000002138 71.0
TLS2_k127_1815159_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 517.0
TLS2_k127_1815159_3 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 439.0
TLS2_k127_1815159_4 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 426.0
TLS2_k127_1815159_5 Peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004795 429.0
TLS2_k127_1815159_6 RmlD substrate binding domain K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 320.0
TLS2_k127_1815159_7 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000001323 256.0
TLS2_k127_1815159_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K19694 - - 0.00000000000000000000000000000000001226 147.0
TLS2_k127_1815159_9 Alpha amylase, catalytic domain - - - 0.000000000000000000000000003919 116.0
TLS2_k127_1894370_0 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000722 585.0
TLS2_k127_1894370_1 Semialdehyde dehydrogenase K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 366.0
TLS2_k127_1894370_10 ATPase activity - - - 0.0000000000000000001348 94.0
TLS2_k127_1894370_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 333.0
TLS2_k127_1894370_3 Protein of unknown function (DUF541) K09797 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 289.0
TLS2_k127_1894370_4 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000003889 252.0
TLS2_k127_1894370_5 PFAM NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003692 251.0
TLS2_k127_1894370_6 Lipopolysaccharide-assembly - - - 0.0000000000000000000000000000000000000000000000001276 186.0
TLS2_k127_1894370_7 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000008308 108.0
TLS2_k127_1894370_8 Protein of unknown function (DUF465) - - - 0.0000000000000000000000006394 106.0
TLS2_k127_1894370_9 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000000000005723 103.0
TLS2_k127_190203_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 586.0
TLS2_k127_190203_1 FAD dependent oxidoreductase K00303,K21061 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 576.0
TLS2_k127_190203_10 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000469 124.0
TLS2_k127_190203_11 Protein of unknown function (DUF2914) - - - 0.00000000000000000001911 104.0
TLS2_k127_190203_12 thiamine biosynthesis protein ThiS K03154 - - 0.00000000000000000008993 90.0
TLS2_k127_190203_2 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 421.0
TLS2_k127_190203_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 326.0
TLS2_k127_190203_4 creatininase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000301 247.0
TLS2_k127_190203_5 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000003093 211.0
TLS2_k127_190203_6 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000000000000000000000003694 174.0
TLS2_k127_190203_7 Amidinotransferase - - - 0.00000000000000000000000000000000000000000002735 183.0
TLS2_k127_190203_8 - - - - 0.0000000000000000000000000000000000000001995 149.0
TLS2_k127_190203_9 - - - - 0.0000000000000000000000000000000000000009722 149.0
TLS2_k127_19435_0 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001291 299.0
TLS2_k127_19435_1 ABC transporter K01990 - - 0.000000000000000000000000000000000000000001893 166.0
TLS2_k127_19435_2 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00000000000000000000002363 103.0
TLS2_k127_19435_3 Transglutaminase-like superfamily - - - 0.0000000000001485 76.0
TLS2_k127_19435_4 PFAM ABC-2 type transporter K01992 - - 0.0005459 51.0
TLS2_k127_1954176_0 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005961 252.0
TLS2_k127_1954176_1 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000000000000000000000000001611 209.0
TLS2_k127_1972507_0 TIGRFAM carbamoyl-phosphate synthase, large subunit K01955 - 6.3.5.5 0.0 1693.0
TLS2_k127_1985468_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.976e-321 995.0
TLS2_k127_1985468_1 homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 1.92e-291 906.0
TLS2_k127_1985468_10 Protein of unknown function (DUF1349) K01183 - 3.2.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 447.0
TLS2_k127_1985468_11 Capsule assembly protein Wzi - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 426.0
TLS2_k127_1985468_12 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 399.0
TLS2_k127_1985468_13 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 344.0
TLS2_k127_1985468_14 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 327.0
TLS2_k127_1985468_15 Chain length determinant protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001109 293.0
TLS2_k127_1985468_16 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001533 292.0
TLS2_k127_1985468_17 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005413 262.0
TLS2_k127_1985468_18 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003641 241.0
TLS2_k127_1985468_19 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000002683 245.0
TLS2_k127_1985468_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 1.339e-282 881.0
TLS2_k127_1985468_20 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000000000000000000000005431 237.0
TLS2_k127_1985468_21 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000000000000000000000000000000000000000000000568 228.0
TLS2_k127_1985468_22 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000001033 200.0
TLS2_k127_1985468_23 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000001603 183.0
TLS2_k127_1985468_24 - - - - 0.0000000000000000000000000000000000000000000008028 183.0
TLS2_k127_1985468_25 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000000000000002598 157.0
TLS2_k127_1985468_26 Participates in transcription elongation, termination and antitermination K02601,K05785 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000229 149.0
TLS2_k127_1985468_27 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000001514 121.0
TLS2_k127_1985468_28 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000682 96.0
TLS2_k127_1985468_29 -O-antigen K02847 - - 0.000000000000002436 89.0
TLS2_k127_1985468_3 Belongs to the GSP D family K02453 - - 1.42e-254 807.0
TLS2_k127_1985468_31 belongs to the aldehyde dehydrogenase family - - - 0.000001943 49.0
TLS2_k127_1985468_4 PFAM Polysaccharide export protein - - - 2.655e-229 748.0
TLS2_k127_1985468_5 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 4.135e-201 640.0
TLS2_k127_1985468_6 PFAM membrane bound O-acyl transferase MBOAT family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 592.0
TLS2_k127_1985468_7 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 590.0
TLS2_k127_1985468_8 phosphorelay sensor kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 499.0
TLS2_k127_1985468_9 stress-induced mitochondrial fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 439.0
TLS2_k127_1989014_0 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 601.0
TLS2_k127_1989014_1 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008218 490.0
TLS2_k127_1989014_10 methyltransferase - - - 0.000000000000000000000000000000005622 137.0
TLS2_k127_1989014_11 BioY family K03523 - - 0.0000000000000000000000000000000331 132.0
TLS2_k127_1989014_12 PFAM Rieske 2Fe-2S K00363 - 1.7.1.15 0.0000000000000000000000000000003534 126.0
TLS2_k127_1989014_14 amino acid K03294 - - 0.00007066 46.0
TLS2_k127_1989014_2 aminopeptidase activity K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 483.0
TLS2_k127_1989014_3 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 430.0
TLS2_k127_1989014_4 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 431.0
TLS2_k127_1989014_5 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 398.0
TLS2_k127_1989014_6 Peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 397.0
TLS2_k127_1989014_7 NADH ubiquinone oxidoreductase, 20 Kd subunit K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009859 334.0
TLS2_k127_1989014_8 cystathionine K01758 - 4.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005965 339.0
TLS2_k127_1989014_9 glycolate biosynthetic process K01560,K07025 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 330.0
TLS2_k127_2013889_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 467.0
TLS2_k127_2013889_1 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000000000000000000000003555 171.0
TLS2_k127_2013889_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000007143 92.0
TLS2_k127_2013889_3 Transcriptional regulatory protein, C terminal - - - 0.00000000000007142 76.0
TLS2_k127_2013889_4 Carboxypeptidase regulatory-like domain - - - 0.00007475 49.0
TLS2_k127_2042677_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1233.0
TLS2_k127_2042677_1 FecR protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 590.0
TLS2_k127_2042677_10 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 445.0
TLS2_k127_2042677_11 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 420.0
TLS2_k127_2042677_12 peroxiredoxin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005651 339.0
TLS2_k127_2042677_13 FeoA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009608 280.0
TLS2_k127_2042677_14 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000005751 263.0
TLS2_k127_2042677_15 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000007076 230.0
TLS2_k127_2042677_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000001105 239.0
TLS2_k127_2042677_17 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000000000000000000000000000000000004224 202.0
TLS2_k127_2042677_18 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000008921 196.0
TLS2_k127_2042677_19 EVE domain - - - 0.00000000000000000000000000000000000000000000000001464 182.0
TLS2_k127_2042677_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 558.0
TLS2_k127_2042677_20 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000004385 147.0
TLS2_k127_2042677_21 Protein of Unknown function (DUF2784) - - - 0.000000000000000000000000000000000001341 143.0
TLS2_k127_2042677_22 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.000000000000000000000000342 108.0
TLS2_k127_2042677_23 Hydrogenase/urease nickel incorporation, metallochaperone, hypA K04651 - - 0.000000001973 65.0
TLS2_k127_2042677_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 551.0
TLS2_k127_2042677_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 549.0
TLS2_k127_2042677_5 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 541.0
TLS2_k127_2042677_6 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 522.0
TLS2_k127_2042677_7 Bacterial protein of unknown function (DUF839) K07093 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 497.0
TLS2_k127_2042677_8 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 473.0
TLS2_k127_2042677_9 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 467.0
TLS2_k127_2053396_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 2.139e-209 680.0
TLS2_k127_2093265_0 Phosphoesterase family K01114 - 3.1.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 389.0
TLS2_k127_2093265_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 340.0
TLS2_k127_2093265_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 296.0
TLS2_k127_2093265_3 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005156 282.0
TLS2_k127_2093265_4 Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000012 279.0
TLS2_k127_2093265_5 SMART cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000495 274.0
TLS2_k127_2093265_6 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000001483 243.0
TLS2_k127_2093265_7 Transcriptional regulator, Crp Fnr family - - - 0.0000000000000000000000000000000000000000000006633 173.0
TLS2_k127_2093265_8 Response regulator, receiver - - - 0.000000000000000000000000000000000001646 147.0
TLS2_k127_2093265_9 - - - - 0.0000000001046 63.0
TLS2_k127_2114330_0 PFAM Aminotransferase, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 450.0
TLS2_k127_2114330_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000004128 110.0
TLS2_k127_2114330_2 Carboxypeptidase regulatory-like domain - - - 0.000154 49.0
TLS2_k127_2123221_0 xanthine dehydrogenase, a b hammerhead K03520,K19820 - 1.2.5.3,1.5.99.4 2.211e-215 689.0
TLS2_k127_2123221_1 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044464,GO:0044689,GO:0050896,GO:0051186,GO:0051188,GO:0051409,GO:0071944 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 359.0
TLS2_k127_2123221_2 COGs COG2080 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS CutS homologs K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000004108 237.0
TLS2_k127_2123221_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000001948 231.0
TLS2_k127_2123221_4 PFAM carbon monoxide dehydrogenase subunit G K09386 - - 0.0000000000000000000000009205 108.0
TLS2_k127_2124716_0 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008982 592.0
TLS2_k127_2124716_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 434.0
TLS2_k127_2124716_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 346.0
TLS2_k127_2124716_3 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000001656 236.0
TLS2_k127_2124716_4 - - - - 0.0000000000000000000000000000000000000000000000000000009962 198.0
TLS2_k127_2124716_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000009128 199.0
TLS2_k127_2138367_0 PFAM Haloacid dehalogenase-like hydrolase - - - 1.488e-209 666.0
TLS2_k127_2138367_1 PFAM Na Pi-cotransporter K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006813 604.0
TLS2_k127_2138367_10 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 349.0
TLS2_k127_2138367_11 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 330.0
TLS2_k127_2138367_12 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 327.0
TLS2_k127_2138367_13 Curli production assembly/transport component CsgG - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 310.0
TLS2_k127_2138367_14 response regulator K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003196 272.0
TLS2_k127_2138367_15 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003822 271.0
TLS2_k127_2138367_16 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000006991 276.0
TLS2_k127_2138367_17 Domain of Unknown function (DUF542) K07322 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001431 256.0
TLS2_k127_2138367_18 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002029 253.0
TLS2_k127_2138367_19 aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002358 260.0
TLS2_k127_2138367_2 Putative zinc-binding metallo-peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 498.0
TLS2_k127_2138367_20 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000001508 215.0
TLS2_k127_2138367_21 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000003827 220.0
TLS2_k127_2138367_22 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000002029 183.0
TLS2_k127_2138367_23 Tryptophan 2,3-dioxygenase K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.00000000000000000000000000000000000000000000001795 181.0
TLS2_k127_2138367_24 antisigma factor binding K03598 - - 0.000000000000000000000000000000000000000000001145 173.0
TLS2_k127_2138367_25 PFAM blue (type 1) copper domain protein - - - 0.000000000000003786 89.0
TLS2_k127_2138367_26 Domain of unknown function (DUF4160) - - - 0.0000000000009499 70.0
TLS2_k127_2138367_27 - - - - 0.000000000002692 75.0
TLS2_k127_2138367_29 peroxiredoxin activity K03386,K03564,K16922 - 1.11.1.15 0.000005305 53.0
TLS2_k127_2138367_3 Multicopper oxidase K22348 - 1.16.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 491.0
TLS2_k127_2138367_30 SCO1/SenC - - - 0.00008835 48.0
TLS2_k127_2138367_4 ATP-grasp domain K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 476.0
TLS2_k127_2138367_5 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 419.0
TLS2_k127_2138367_6 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008875 391.0
TLS2_k127_2138367_7 metallopeptidase activity K06212,K06402 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 377.0
TLS2_k127_2138367_8 Outer membrane efflux protein K15725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007501 376.0
TLS2_k127_2138367_9 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 353.0
TLS2_k127_2154790_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 511.0
TLS2_k127_2154790_1 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 461.0
TLS2_k127_2154790_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 375.0
TLS2_k127_2154790_3 - - - - 0.000000000000000000000000000000000000000000000000003652 185.0
TLS2_k127_2154790_4 methyltransferase - - - 0.000000000000000000000000000000000000000000000000007575 188.0
TLS2_k127_2154790_5 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000001313 122.0
TLS2_k127_2159068_0 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.0 1036.0
TLS2_k127_2159068_1 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 5.71e-208 659.0
TLS2_k127_2159068_10 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004445 364.0
TLS2_k127_2159068_11 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007881 315.0
TLS2_k127_2159068_12 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000000000001832 237.0
TLS2_k127_2159068_13 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000000000000000000000003201 218.0
TLS2_k127_2159068_14 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000000000000001736 162.0
TLS2_k127_2159068_15 Transposase K07491 - - 0.00000000000000000000000000000000000002971 150.0
TLS2_k127_2159068_16 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000000001433 136.0
TLS2_k127_2159068_17 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000006403 132.0
TLS2_k127_2159068_18 Cold shock protein K03704 - - 0.0000000000000000000000000000001963 124.0
TLS2_k127_2159068_19 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000001009 100.0
TLS2_k127_2159068_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 4.936e-205 647.0
TLS2_k127_2159068_21 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00001205 56.0
TLS2_k127_2159068_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 557.0
TLS2_k127_2159068_4 Selenocysteine synthase N terminal K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 542.0
TLS2_k127_2159068_5 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 527.0
TLS2_k127_2159068_6 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 518.0
TLS2_k127_2159068_7 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 501.0
TLS2_k127_2159068_8 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 479.0
TLS2_k127_2159068_9 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 408.0
TLS2_k127_2184396_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008335 547.0
TLS2_k127_2184396_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 535.0
TLS2_k127_2184396_2 Amidase K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 449.0
TLS2_k127_2184396_3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 366.0
TLS2_k127_2184396_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 306.0
TLS2_k127_2184396_5 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000047 274.0
TLS2_k127_2184396_6 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000008311 236.0
TLS2_k127_2184396_7 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000000000001248 222.0
TLS2_k127_2184396_8 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.0000000000000000000000000000000000000000000000000000002147 204.0
TLS2_k127_2184396_9 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000004722 202.0
TLS2_k127_2250674_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0 1361.0
TLS2_k127_2250674_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 9.3e-246 777.0
TLS2_k127_2250674_11 Phage integrase family - - - 0.0002035 46.0
TLS2_k127_2250674_12 - - - - 0.0003504 43.0
TLS2_k127_2250674_2 mannose-ethanolamine phosphotransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 580.0
TLS2_k127_2250674_3 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 445.0
TLS2_k127_2250674_4 Mechanosensitive ion channel K05802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 362.0
TLS2_k127_2250674_5 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 346.0
TLS2_k127_2250674_6 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 361.0
TLS2_k127_2250674_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001541 261.0
TLS2_k127_2250674_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004303 244.0
TLS2_k127_2250674_9 amino acid K03294 - - 0.000000000000000000000000000000000000000001045 158.0
TLS2_k127_2290835_0 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 407.0
TLS2_k127_2290835_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 303.0
TLS2_k127_2290835_2 stress-induced mitochondrial fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001551 257.0
TLS2_k127_2290835_3 CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000003929 220.0
TLS2_k127_2290835_4 Reverse transcriptase-like K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000003487 175.0
TLS2_k127_2290835_5 - - - - 0.00000000000000000000000005364 116.0
TLS2_k127_2290835_6 Yqey-like protein K09117 - - 0.00003723 46.0
TLS2_k127_2299153_0 Amidohydrolase family - - - 1.205e-212 674.0
TLS2_k127_2299153_1 Insulinase (Peptidase family M16) - - - 9.241e-197 625.0
TLS2_k127_2299153_2 Aldehyde dehydrogenase family K22445 - 1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 548.0
TLS2_k127_2299153_3 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 437.0
TLS2_k127_2299153_4 Peptidase, M20 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 426.0
TLS2_k127_2299153_5 Peptidase M16 inactive domain K07263 - - 0.0000000000000000000000000000000000000000000000000000000000003642 224.0
TLS2_k127_2299153_6 - - - - 0.0000000000008824 78.0
TLS2_k127_2336024_0 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 404.0
TLS2_k127_2336024_1 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000003543 194.0
TLS2_k127_2336024_2 PFAM Peptidase M22, glycoprotease K14742 - - 0.000000000000000000000989 106.0
TLS2_k127_2342780_0 PLD-like domain K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005921 427.0
TLS2_k127_2342780_1 Glycosyl transferase family group 2 K00720 - 2.4.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 380.0
TLS2_k127_2342780_2 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000000000000008117 185.0
TLS2_k127_2342780_3 - - - - 0.000000000000402 69.0
TLS2_k127_2342780_4 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.00000004283 54.0
TLS2_k127_2376029_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K07516 - 1.1.1.35 2.513e-226 708.0
TLS2_k127_2376029_1 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000008109 202.0
TLS2_k127_2377153_0 Male sterility protein K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003999 340.0
TLS2_k127_2377153_1 slime layer polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001215 275.0
TLS2_k127_2377153_2 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000004441 121.0
TLS2_k127_2377153_3 haloacid dehalogenase-like hydrolase - - - 0.0000000000000846 85.0
TLS2_k127_2377153_4 Domain of unknown function (DUF4440) - - - 0.000000000005249 72.0
TLS2_k127_2384484_0 TonB dependent receptor - - - 0.0 1110.0
TLS2_k127_2384484_1 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 6.787e-312 978.0
TLS2_k127_2384484_10 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007406 362.0
TLS2_k127_2384484_11 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 387.0
TLS2_k127_2384484_12 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005741 347.0
TLS2_k127_2384484_13 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006515 345.0
TLS2_k127_2384484_14 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001928 276.0
TLS2_k127_2384484_15 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K00082 - 1.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000001105 272.0
TLS2_k127_2384484_16 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000000000000000000000000000000001306 262.0
TLS2_k127_2384484_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000006742 245.0
TLS2_k127_2384484_18 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001125 243.0
TLS2_k127_2384484_19 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase K00996 - 2.7.8.6 0.000000000000000000000000000000000000000000000000000000000002591 219.0
TLS2_k127_2384484_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 5.243e-277 861.0
TLS2_k127_2384484_21 - - - - 0.000000000000000000000000000000000000000000000000000000001166 217.0
TLS2_k127_2384484_22 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000004099 208.0
TLS2_k127_2384484_23 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000002365 195.0
TLS2_k127_2384484_24 dead deah K03724 - - 0.0000000000000000000000000000000000000000000000002513 178.0
TLS2_k127_2384484_25 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000003878 187.0
TLS2_k127_2384484_26 Type II secretory pathway component ExeA K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000007694 194.0
TLS2_k127_2384484_27 Chain length determinant protein - - - 0.000000000000000000000000000000000000000000002069 183.0
TLS2_k127_2384484_28 PFAM Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000007521 174.0
TLS2_k127_2384484_29 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000005958 175.0
TLS2_k127_2384484_3 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 6.201e-275 863.0
TLS2_k127_2384484_30 Transcription termination factor nusG - - - 0.00000000000000000000000000000000000000005791 158.0
TLS2_k127_2384484_31 Putative Ig domain - - - 0.0000000000000000000000000000000000000133 164.0
TLS2_k127_2384484_32 response regulator - - - 0.0000000000000000000000000000000000216 145.0
TLS2_k127_2384484_33 - - - - 0.00000000000000000000000000000000003651 147.0
TLS2_k127_2384484_34 - - - - 0.000000000000000000000000000000003278 137.0
TLS2_k127_2384484_35 PFAM O-antigen polymerase - - - 0.000000000000000000000000000000004152 145.0
TLS2_k127_2384484_36 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity K13991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464 - 0.0000000000000000000000000000003277 128.0
TLS2_k127_2384484_37 Phosphotransferase enzyme family - - - 0.000000000000000000000000000009549 133.0
TLS2_k127_2384484_4 serine threonine protein kinase K12132 - 2.7.11.1 1.96e-221 721.0
TLS2_k127_2384484_41 Tetratricopeptide repeat - - - 0.000000000000000000005599 109.0
TLS2_k127_2384484_42 Polysaccharide biosynthesis/export protein - - - 0.0000000000000000001622 98.0
TLS2_k127_2384484_43 - - - - 0.00000000000000137 91.0
TLS2_k127_2384484_44 protein involved in exopolysaccharide biosynthesis K16554 - - 0.000000000000001649 86.0
TLS2_k127_2384484_47 acid phosphatase activity K03651 - 3.1.4.53 0.0000000000005399 74.0
TLS2_k127_2384484_48 TIGRFAM TonB K03832 - - 0.000000000005196 79.0
TLS2_k127_2384484_49 His Kinase A (phosphoacceptor) domain - - - 0.000002238 51.0
TLS2_k127_2384484_5 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009081 526.0
TLS2_k127_2384484_50 Polysaccharide biosynthesis protein - - - 0.0000372 56.0
TLS2_k127_2384484_51 Beta protein - - - 0.00007258 52.0
TLS2_k127_2384484_6 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 454.0
TLS2_k127_2384484_7 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 419.0
TLS2_k127_2384484_8 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 449.0
TLS2_k127_2384484_9 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 409.0
TLS2_k127_2430626_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1054.0
TLS2_k127_2430626_1 Peptidase family M1 domain - - - 1.136e-233 747.0
TLS2_k127_244963_0 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000009254 211.0
TLS2_k127_244963_1 FecR protein - - - 0.0000000000000000000000000000000000000000000000624 189.0
TLS2_k127_244963_2 - - - - 0.000000000000000000000112 109.0
TLS2_k127_2488571_0 Protein involved in amylo-alpha-1,6-glucosidase activity and glycogen biosynthetic process - - - 5.21e-274 864.0
TLS2_k127_2488571_1 Peptidase family M1 domain - - - 2.838e-216 702.0
TLS2_k127_2488571_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 405.0
TLS2_k127_2488571_3 - - - - 0.00001963 56.0
TLS2_k127_2488571_4 - - - - 0.0001006 53.0
TLS2_k127_2522776_0 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000001046 207.0
TLS2_k127_2522776_1 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000005206 170.0
TLS2_k127_2522776_2 - - - - 0.0000000000000000000005437 109.0
TLS2_k127_2522776_3 Bacterioferritin comigratory K03564 - 1.11.1.15 0.00000000000004821 72.0
TLS2_k127_2612647_0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 4.728e-278 862.0
TLS2_k127_2612647_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.488e-261 826.0
TLS2_k127_2612647_10 23S rRNA-intervening sequence protein - - - 0.0000000000000000000000000000000005837 135.0
TLS2_k127_2612647_11 - - - - 0.0001546 46.0
TLS2_k127_2612647_2 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 486.0
TLS2_k127_2612647_3 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 425.0
TLS2_k127_2612647_4 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 329.0
TLS2_k127_2612647_5 TIGRFAM potassium uptake protein, TrkH family K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 328.0
TLS2_k127_2612647_6 TIGRFAM potassium uptake protein, TrkH family K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 325.0
TLS2_k127_2612647_7 Conserved TM helix - - - 0.000000000000000000000000000000000000000000000000000003628 199.0
TLS2_k127_2612647_8 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain K03499 - - 0.000000000000000000000000000000000000000000000000001585 190.0
TLS2_k127_2612647_9 - - - - 0.0000000000000000000000000000000000000003948 150.0
TLS2_k127_2640416_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 2.65e-265 828.0
TLS2_k127_2640416_1 xanthine dehydrogenase activity K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 390.0
TLS2_k127_2640416_2 PFAM von Willebrand factor type A - - - 0.0000000000000000000000000000000000000000000000000000000000000007422 231.0
TLS2_k127_2640416_3 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000335 221.0
TLS2_k127_2640416_4 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000001157 207.0
TLS2_k127_2640416_5 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000005006 186.0
TLS2_k127_2640416_6 - - - - 0.00000000000000000000000000001141 121.0
TLS2_k127_2806457_0 Tetratricopeptide repeat - - - 0.0 1560.0
TLS2_k127_2806457_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0 1124.0
TLS2_k127_2806457_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001572 266.0
TLS2_k127_2806457_11 TspO/MBR family - - - 0.000000000000000000000000000000000000000000000001835 177.0
TLS2_k127_2806457_12 antisigma factor binding K04749 - - 0.000000000000000000000000000000000000000000000008542 175.0
TLS2_k127_2806457_13 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000000273 164.0
TLS2_k127_2806457_14 - - - - 0.00000000000000000000000000000000001318 145.0
TLS2_k127_2806457_16 - - - - 0.0000000000000000421 89.0
TLS2_k127_2806457_17 Membrane protease subunits, stomatin prohibitin homologs - - - 0.00000000001272 72.0
TLS2_k127_2806457_18 alpha beta alpha domain I K16881 - 2.7.7.13,5.4.2.8 0.0000141 57.0
TLS2_k127_2806457_19 Pyridoxamine 5'-phosphate oxidase - - - 0.0007259 45.0
TLS2_k127_2806457_2 Psort location CytoplasmicMembrane, score - - - 3.449e-243 764.0
TLS2_k127_2806457_3 Glycosyl transferases group 1 - - - 6.858e-195 616.0
TLS2_k127_2806457_4 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 507.0
TLS2_k127_2806457_5 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 493.0
TLS2_k127_2806457_6 May be involved in the transport of PQQ or its precursor to the periplasm K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 476.0
TLS2_k127_2806457_7 polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 428.0
TLS2_k127_2806457_8 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007153 279.0
TLS2_k127_2806457_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006658 282.0
TLS2_k127_2811584_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1420.0
TLS2_k127_2811584_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1306.0
TLS2_k127_2811584_10 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006401 560.0
TLS2_k127_2811584_11 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 544.0
TLS2_k127_2811584_12 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 475.0
TLS2_k127_2811584_13 Belongs to the GSP D family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004588 481.0
TLS2_k127_2811584_14 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 456.0
TLS2_k127_2811584_15 Oxidoreductase molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 462.0
TLS2_k127_2811584_16 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 444.0
TLS2_k127_2811584_17 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 432.0
TLS2_k127_2811584_18 XdhC and CoxI family K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 406.0
TLS2_k127_2811584_19 Gram-negative bacterial TonB protein C-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 390.0
TLS2_k127_2811584_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1255.0
TLS2_k127_2811584_20 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 381.0
TLS2_k127_2811584_21 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 372.0
TLS2_k127_2811584_22 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 363.0
TLS2_k127_2811584_23 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 352.0
TLS2_k127_2811584_24 PFAM Chlorite dismutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 351.0
TLS2_k127_2811584_25 Fungal family of unknown function (DUF1776) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007767 355.0
TLS2_k127_2811584_26 RNA polymerase sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 327.0
TLS2_k127_2811584_27 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 321.0
TLS2_k127_2811584_28 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 333.0
TLS2_k127_2811584_29 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 316.0
TLS2_k127_2811584_3 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ - - - 9.377e-265 821.0
TLS2_k127_2811584_30 nucleotide metabolic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 305.0
TLS2_k127_2811584_31 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 312.0
TLS2_k127_2811584_32 Radical SAM superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 302.0
TLS2_k127_2811584_33 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 298.0
TLS2_k127_2811584_34 synthase K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 292.0
TLS2_k127_2811584_35 Beta-lactamase K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005664 283.0
TLS2_k127_2811584_36 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000005081 269.0
TLS2_k127_2811584_37 MobA-Related Protein K07141,K19190 - 1.1.1.328,2.7.7.76 0.00000000000000000000000000000000000000000000000000000000000000000000001272 247.0
TLS2_k127_2811584_38 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001068 253.0
TLS2_k127_2811584_39 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000003031 247.0
TLS2_k127_2811584_4 Leukotriene A4 hydrolase, C-terminal - - - 2.56e-242 765.0
TLS2_k127_2811584_40 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000003638 234.0
TLS2_k127_2811584_41 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000002307 234.0
TLS2_k127_2811584_42 PFAM Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000008029 224.0
TLS2_k127_2811584_43 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000000000000004542 234.0
TLS2_k127_2811584_44 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000008465 218.0
TLS2_k127_2811584_45 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.00000000000000000000000000000000000000000000000000001089 198.0
TLS2_k127_2811584_46 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.00000000000000000000000000000000000000000000000000005842 193.0
TLS2_k127_2811584_47 amine dehydrogenase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000001709 194.0
TLS2_k127_2811584_48 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.0000000000000000000000000000000000000000000000002118 180.0
TLS2_k127_2811584_49 phytanoyl-CoA dioxygenase - - - 0.000000000000000000000000000000000000000000000007498 180.0
TLS2_k127_2811584_5 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 2.749e-225 714.0
TLS2_k127_2811584_50 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000009403 180.0
TLS2_k127_2811584_51 NUDIX domain K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000002477 170.0
TLS2_k127_2811584_52 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000003506 167.0
TLS2_k127_2811584_53 nuclear chromosome segregation - - - 0.0000000000000000000000000000000000000000004743 172.0
TLS2_k127_2811584_54 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000005313 158.0
TLS2_k127_2811584_55 membrane - - - 0.00000000000000000000000000000000005654 138.0
TLS2_k127_2811584_56 Putative zinc-finger - - - 0.000000000000000000000000000000005591 129.0
TLS2_k127_2811584_57 - - - - 0.00000000000000000000000000000005824 133.0
TLS2_k127_2811584_58 membrane - - - 0.00000000000000000000000000001075 123.0
TLS2_k127_2811584_59 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000697 113.0
TLS2_k127_2811584_6 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 4.895e-204 649.0
TLS2_k127_2811584_60 - - - - 0.00000000000000000000008583 106.0
TLS2_k127_2811584_62 - - - - 0.000000000000000002875 86.0
TLS2_k127_2811584_7 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 1.503e-202 646.0
TLS2_k127_2811584_8 extracellular solute-binding protein, family 5 K02035 - - 4.89e-200 640.0
TLS2_k127_2811584_9 FAD dependent oxidoreductase K00514 - 1.3.5.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 567.0
TLS2_k127_2815475_0 C-terminal, D2-small domain, of ClpB protein - - - 1.145e-209 657.0
TLS2_k127_2815475_1 Type II/IV secretion system protein K02669 - - 1.879e-209 656.0
TLS2_k127_2815475_10 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 308.0
TLS2_k127_2815475_11 Aminotransferase class-V K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000003328 217.0
TLS2_k127_2815475_12 Modulates RecA activity K03565 - - 0.000000000000000000000000000000000000000000000002385 179.0
TLS2_k127_2815475_13 DinB family - - - 0.000000000000000000000000000000000000001676 153.0
TLS2_k127_2815475_14 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000002112 145.0
TLS2_k127_2815475_15 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000000001257 115.0
TLS2_k127_2815475_16 - - - - 0.000000000000000000003129 97.0
TLS2_k127_2815475_17 domain, Protein K02450,K07126,K15539 - - 0.00000000000002539 85.0
TLS2_k127_2815475_2 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 549.0
TLS2_k127_2815475_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 455.0
TLS2_k127_2815475_4 PFAM von Willebrand factor type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005493 394.0
TLS2_k127_2815475_5 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 366.0
TLS2_k127_2815475_6 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 352.0
TLS2_k127_2815475_7 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 362.0
TLS2_k127_2815475_8 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 359.0
TLS2_k127_2815475_9 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 314.0
TLS2_k127_2820586_0 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 496.0
TLS2_k127_2820586_1 COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00978 - 2.7.7.33 0.0000000000000000000000000000000000000000000000000001723 186.0
TLS2_k127_2820586_2 Putative zinc binding domain - - - 0.0000000000000000000000000000000000000000204 157.0
TLS2_k127_2823150_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 440.0
TLS2_k127_2823150_1 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000341 224.0
TLS2_k127_2823150_2 - - - - 0.0007009 52.0
TLS2_k127_283672_0 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 400.0
TLS2_k127_283672_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000063 306.0
TLS2_k127_283672_2 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000000000000000000000004211 187.0
TLS2_k127_283672_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000001627 186.0
TLS2_k127_283672_4 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000004848 174.0
TLS2_k127_283672_5 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000000000000589 96.0
TLS2_k127_2852036_0 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 361.0
TLS2_k127_2852036_1 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000006731 205.0
TLS2_k127_2852036_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000002824 203.0
TLS2_k127_2852036_3 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.000000000000000000000005015 107.0
TLS2_k127_2880819_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 2282.0
TLS2_k127_2880819_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 378.0
TLS2_k127_2880819_2 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 327.0
TLS2_k127_2880819_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004994 241.0
TLS2_k127_2880819_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000006582 235.0
TLS2_k127_2880819_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000000000003464 186.0
TLS2_k127_2880819_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000000000000000003499 125.0
TLS2_k127_2880819_7 Ribosomal protein L33 K02913 - - 0.00000000000000000000001755 101.0
TLS2_k127_2880819_8 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00000000000000000004888 95.0
TLS2_k127_2891226_0 GGDEF domain - - - 2.253e-268 853.0
TLS2_k127_2891226_1 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 595.0
TLS2_k127_2891226_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 383.0
TLS2_k127_2891226_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000006972 193.0
TLS2_k127_2891226_4 Transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000000000000471 172.0
TLS2_k127_2891226_5 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000001629 153.0
TLS2_k127_2891226_6 - - - - 0.0002217 52.0
TLS2_k127_2900693_0 PA domain - - - 8.031e-202 644.0
TLS2_k127_2900693_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008223 597.0
TLS2_k127_2900693_10 Leucine-rich repeat (LRR) protein - - - 0.00007981 57.0
TLS2_k127_2900693_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 446.0
TLS2_k127_2900693_3 FES K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 313.0
TLS2_k127_2900693_4 Redoxin - - - 0.000000000000000000000000000000000008746 148.0
TLS2_k127_2900693_5 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000002332 157.0
TLS2_k127_2900693_6 Belongs to the globin family - - - 0.000000000000000000000001903 121.0
TLS2_k127_2900693_7 histone H2A K63-linked ubiquitination - - - 0.00000000000000002221 87.0
TLS2_k127_2900693_8 metalloendoproteinase 1-like K01402,K07999 - 3.4.24.34 0.000000001136 70.0
TLS2_k127_2900693_9 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000001332 55.0
TLS2_k127_2905090_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000005351 138.0
TLS2_k127_2905090_1 Cadherin repeats. - - - 0.000000007903 70.0
TLS2_k127_2905942_0 WD40-like Beta Propeller Repeat - - - 3.925e-230 747.0
TLS2_k127_2905942_1 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 504.0
TLS2_k127_2905942_10 STAS domain - - - 0.000003531 54.0
TLS2_k127_2905942_2 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 462.0
TLS2_k127_2905942_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 393.0
TLS2_k127_2905942_4 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007717 319.0
TLS2_k127_2905942_5 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001319 244.0
TLS2_k127_2905942_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000002549 245.0
TLS2_k127_2905942_7 PFAM secretion protein HlyD family protein K02005,K02022 - - 0.0000000000000000000000000000000000000000000000005129 192.0
TLS2_k127_2905942_8 efflux transmembrane transporter activity K12340 - - 0.00000000000000000000000000000000000000000001508 182.0
TLS2_k127_2945213_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 7.141e-212 668.0
TLS2_k127_2945213_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 593.0
TLS2_k127_2945213_10 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000004339 92.0
TLS2_k127_2945213_11 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000000001968 84.0
TLS2_k127_2945213_2 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 596.0
TLS2_k127_2945213_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 558.0
TLS2_k127_2945213_4 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008181 349.0
TLS2_k127_2945213_5 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000009871 245.0
TLS2_k127_2945213_6 R3H domain K06346 - - 0.000000000000000000000000000000000000000000000000000005449 199.0
TLS2_k127_2945213_7 PFAM von Willebrand factor type A - - - 0.000000000000000000000000001828 123.0
TLS2_k127_2945213_8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000000001802 115.0
TLS2_k127_2950017_0 AAA ATPase K07478 - - 3.318e-217 680.0
TLS2_k127_2950017_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 545.0
TLS2_k127_2950017_10 PFAM S23 ribosomal protein - - - 0.000000000000000000000000000001647 123.0
TLS2_k127_2950017_11 Transcriptional regulator K07729 - - 0.0000000000000000000001305 101.0
TLS2_k127_2950017_12 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 0.0000000000000000001858 91.0
TLS2_k127_2950017_13 - - - - 0.000005699 56.0
TLS2_k127_2950017_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 531.0
TLS2_k127_2950017_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 314.0
TLS2_k127_2950017_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 300.0
TLS2_k127_2950017_5 Belongs to the SUA5 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001789 265.0
TLS2_k127_2950017_6 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004397 245.0
TLS2_k127_2950017_7 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000004805 209.0
TLS2_k127_2950017_8 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000000000002158 194.0
TLS2_k127_2950017_9 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000001968 169.0
TLS2_k127_2952294_0 CarboxypepD_reg-like domain - - - 1.792e-263 857.0
TLS2_k127_2952294_1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001359 244.0
TLS2_k127_2952294_2 - - - - 0.0000000000000000000000000002905 120.0
TLS2_k127_2952294_4 Delta-1-pyrroline-5-carboxylate dehydrogenase K00294 - 1.2.1.88 0.0000000000000001415 86.0
TLS2_k127_2952294_5 LexA-binding, inner membrane-associated putative hydrolase - - - 0.0000000000000004877 81.0
TLS2_k127_2991403_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1105.0
TLS2_k127_2991403_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.083e-244 761.0
TLS2_k127_2991403_10 Belongs to the GPI family K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 364.0
TLS2_k127_2991403_11 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006425 333.0
TLS2_k127_2991403_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 314.0
TLS2_k127_2991403_13 Thioredoxin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007785 253.0
TLS2_k127_2991403_14 - - - - 0.000000000000000000000000000000000000000000000000000000001357 205.0
TLS2_k127_2991403_15 Mov34 MPN PAD-1 - - - 0.00000000000000000000000000000000000000000000000000002014 193.0
TLS2_k127_2991403_16 RNA signal recognition particle 4.5S RNA - - - 0.0000000000000000000000000000000000000000000000003516 181.0
TLS2_k127_2991403_17 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000000000003564 169.0
TLS2_k127_2991403_18 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000002684 153.0
TLS2_k127_2991403_19 - - - - 0.0000000000000000000000000000000001621 140.0
TLS2_k127_2991403_2 PFAM Organic solvent tolerance protein K04744 - - 5.264e-239 764.0
TLS2_k127_2991403_20 ThiS family K03636 - - 0.000000000000000000000000000000002813 131.0
TLS2_k127_2991403_21 pfam rdd - - - 0.000000000000000000000000007909 129.0
TLS2_k127_2991403_22 Lactonase, 7-bladed beta-propeller - - - 0.0000000003271 72.0
TLS2_k127_2991403_23 Putative prokaryotic signal transducing protein - - - 0.00003791 57.0
TLS2_k127_2991403_3 Elongation factor SelB, winged helix K03833 - - 4.978e-227 727.0
TLS2_k127_2991403_4 cellulose binding - - - 6.27e-215 679.0
TLS2_k127_2991403_5 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 600.0
TLS2_k127_2991403_6 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 447.0
TLS2_k127_2991403_7 Pyridoxal-phosphate dependent enzyme K12339 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 427.0
TLS2_k127_2991403_8 Peptidylprolyl isomerase K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 399.0
TLS2_k127_2991403_9 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 359.0
TLS2_k127_3010663_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004855 596.0
TLS2_k127_3010663_1 Aminotransferase, class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 499.0
TLS2_k127_3010663_2 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 378.0
TLS2_k127_3010663_4 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000000000000000000000000002563 185.0
TLS2_k127_3010663_5 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000001528 171.0
TLS2_k127_3010663_6 - - - - 0.0000009707 61.0
TLS2_k127_3042539_0 - K17285 - - 0.0 1386.0
TLS2_k127_3042539_1 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.0 1232.0
TLS2_k127_3042539_10 NADH dehydrogenase K00335,K18331 - 1.12.1.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003086 404.0
TLS2_k127_3042539_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006614 401.0
TLS2_k127_3042539_12 Alpha amylase catalytic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 344.0
TLS2_k127_3042539_13 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004646 344.0
TLS2_k127_3042539_14 Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway K00068,K18124,K18125 GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005515,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0046872,GO:0046914,GO:0046983,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.140,1.1.1.359,1.1.1.360 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 312.0
TLS2_k127_3042539_15 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005799 265.0
TLS2_k127_3042539_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000002047 223.0
TLS2_k127_3042539_17 ATPase activity - - - 0.000000000000000000000000000000000000000000000000000002774 208.0
TLS2_k127_3042539_18 Belongs to the MIP aquaporin (TC 1.A.8) family K02440,K06188 - - 0.000000000000000000000000000000000000000000000000003379 196.0
TLS2_k127_3042539_19 - - - - 0.00000000000000000000000000000000000003887 146.0
TLS2_k127_3042539_2 Peptidase family M1 domain - - - 2.826e-250 791.0
TLS2_k127_3042539_20 cyclic nucleotide binding K10914 - - 0.00000000000005279 84.0
TLS2_k127_3042539_21 - - - - 0.00000000001872 67.0
TLS2_k127_3042539_3 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 629.0
TLS2_k127_3042539_4 - K11891,K16091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004577 532.0
TLS2_k127_3042539_5 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 484.0
TLS2_k127_3042539_6 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 478.0
TLS2_k127_3042539_7 ABC transporter, transmembrane K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 448.0
TLS2_k127_3042539_8 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 446.0
TLS2_k127_3042539_9 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 426.0
TLS2_k127_3048613_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 441.0
TLS2_k127_3048613_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000006324 205.0
TLS2_k127_3061295_0 RecQ zinc-binding K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 554.0
TLS2_k127_3062061_0 Belongs to the glycosyl hydrolase 57 family - - - 0.0 1041.0
TLS2_k127_3062061_1 Malate synthase K01638 - 2.3.3.9 1.557e-232 731.0
TLS2_k127_3062061_10 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009893 342.0
TLS2_k127_3062061_11 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006137 321.0
TLS2_k127_3062061_12 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000481 337.0
TLS2_k127_3062061_13 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 323.0
TLS2_k127_3062061_14 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 302.0
TLS2_k127_3062061_15 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003222 250.0
TLS2_k127_3062061_16 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000002598 230.0
TLS2_k127_3062061_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000211 220.0
TLS2_k127_3062061_18 YbbR-like protein - - - 0.0000000000000000000000000000000000000000000000000000003204 202.0
TLS2_k127_3062061_19 - - - - 0.000000000000000000000000000000000000000000000000000004358 203.0
TLS2_k127_3062061_2 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 604.0
TLS2_k127_3062061_20 Domain of unknown function (DUF1990) - - - 0.000000000000000000000000000000000000000000000000008089 186.0
TLS2_k127_3062061_21 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000005803 150.0
TLS2_k127_3062061_22 bacterial (prokaryotic) histone like domain K03530 - - 0.000000000000000000000000000000000022 140.0
TLS2_k127_3062061_23 Binds the 23S rRNA K02909 - - 0.000000000000000000000000000000005533 131.0
TLS2_k127_3062061_25 RDD family - - - 0.00000000003656 71.0
TLS2_k127_3062061_26 SnoaL-like polyketide cyclase - - - 0.0000000000371 69.0
TLS2_k127_3062061_27 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000007272 66.0
TLS2_k127_3062061_3 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008899 585.0
TLS2_k127_3062061_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009682 557.0
TLS2_k127_3062061_5 synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 485.0
TLS2_k127_3062061_6 PFAM Mur ligase K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 478.0
TLS2_k127_3062061_7 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 470.0
TLS2_k127_3062061_8 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 432.0
TLS2_k127_3062061_9 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 408.0
TLS2_k127_3074373_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 568.0
TLS2_k127_3074373_1 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000007817 197.0
TLS2_k127_3074373_2 Protein of unknown function (DUF1385) - - - 0.000000000000001999 76.0
TLS2_k127_3074373_3 Gram-negative bacterial TonB protein C-terminal - - - 0.0000002669 60.0
TLS2_k127_309317_0 Fumarase C C-terminus K01744 - 4.3.1.1 4.746e-234 733.0
TLS2_k127_309317_1 Domain of unknown function (DUF3488) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 623.0
TLS2_k127_309317_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 511.0
TLS2_k127_309317_3 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 493.0
TLS2_k127_309317_4 Transcriptional regulator PadR-like family - - - 0.000000000000000000002207 96.0
TLS2_k127_309317_5 von Willebrand factor, type A - - - 0.000000001165 68.0
TLS2_k127_3105600_0 Mu-like prophage FluMu protein gp28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 290.0
TLS2_k127_3105600_1 phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000454 213.0
TLS2_k127_3105600_2 - K21449 - - 0.000000000000000000000000000000000000014 168.0
TLS2_k127_3105600_3 C-terminal domain of CHU protein family - - - 0.0007271 52.0
TLS2_k127_3105600_4 Pectate lyase superfamily protein - - - 0.0007406 53.0
TLS2_k127_3146967_0 Acetamidase/Formamidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 302.0
TLS2_k127_3146967_1 - - - - 0.0000000000000000000000000000000000000000000001335 186.0
TLS2_k127_3157658_0 Beta-eliminating lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 570.0
TLS2_k127_3157658_1 phosphoribosylamine-glycine ligase activity K01755,K01955 - 4.3.2.1,6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 383.0
TLS2_k127_3157658_2 acid phosphatase activity K03651 - 3.1.4.53 0.000000000000000000000000000000000000000000000000000000000000001775 237.0
TLS2_k127_3157658_3 acid phosphatase activity K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000000007152 232.0
TLS2_k127_3157658_4 Bacterial sugar transferase K21303 - 2.7.8.40 0.0000000000000000000000000000000000000000000000000000000000004561 226.0
TLS2_k127_3157658_5 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000317 204.0
TLS2_k127_3162123_0 PFAM Amidase - - - 4.801e-223 705.0
TLS2_k127_3162123_1 Outer membrane protein beta-barrel domain K12980 - - 0.00000000000409 78.0
TLS2_k127_3162123_2 Ami_3 K01448 - 3.5.1.28 0.000018 57.0
TLS2_k127_3202722_0 Peptidase M56 - - - 4.234e-214 681.0
TLS2_k127_3202722_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 541.0
TLS2_k127_3202722_2 DNA integration - - - 0.000000000000000000000000000000000000006925 154.0
TLS2_k127_3218857_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005705 446.0
TLS2_k127_3218857_1 peptidase S1 and S6 chymotrypsin Hap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008369 407.0
TLS2_k127_3218857_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000001029 219.0
TLS2_k127_3218857_3 - - - - 0.00000000000004522 79.0
TLS2_k127_3218857_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000001209 74.0
TLS2_k127_3218857_5 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000001167 72.0
TLS2_k127_3218857_6 Trm112p-like protein K09791 - - 0.000000001268 64.0
TLS2_k127_3246725_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 3.267e-256 801.0
TLS2_k127_3246725_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 4.327e-225 728.0
TLS2_k127_3246725_10 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 333.0
TLS2_k127_3246725_11 spore germination - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 330.0
TLS2_k127_3246725_12 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 332.0
TLS2_k127_3246725_13 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 325.0
TLS2_k127_3246725_14 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008903 275.0
TLS2_k127_3246725_15 OsmC-like protein K07397 - - 0.0000000000000000000000000000000000000002953 155.0
TLS2_k127_3246725_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000003859 119.0
TLS2_k127_3246725_17 Glutaredoxin - - - 0.00000000000000000005142 96.0
TLS2_k127_3246725_18 peroxiredoxin activity - - - 0.0000000000000000003253 94.0
TLS2_k127_3246725_19 mttA/Hcf106 family K03117 - - 0.000000000000001286 81.0
TLS2_k127_3246725_2 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 4.667e-213 675.0
TLS2_k127_3246725_21 Regulatory protein, FmdB family - - - 0.0000000000009104 69.0
TLS2_k127_3246725_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009794 526.0
TLS2_k127_3246725_4 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006659 505.0
TLS2_k127_3246725_5 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000088 456.0
TLS2_k127_3246725_6 PFAM Bile acid sodium symporter K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 466.0
TLS2_k127_3246725_7 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 428.0
TLS2_k127_3246725_8 Integral membrane protein TerC family K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 367.0
TLS2_k127_3246725_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 346.0
TLS2_k127_3256222_0 PFAM Cytochrome c assembly protein K02198 - - 3.259e-305 947.0
TLS2_k127_3256222_1 Domain of unknown function (DUF4382) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008546 383.0
TLS2_k127_3256222_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009862 346.0
TLS2_k127_3256222_3 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007624 246.0
TLS2_k127_3256222_4 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000001292 143.0
TLS2_k127_3256222_5 - - - - 0.00000000000000007996 91.0
TLS2_k127_3256222_6 Amidohydrolase family - - - 0.0000000001875 64.0
TLS2_k127_3256222_7 - - - - 0.000000000857 65.0
TLS2_k127_326210_0 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 1.1e-284 894.0
TLS2_k127_326210_1 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 481.0
TLS2_k127_326210_10 Diacylglycerol kinase catalytic domain (presumed) - - - 0.00000000000000000000000000000000002721 148.0
TLS2_k127_326210_11 Enoyl-CoA hydratase/isomerase K13767 - 4.2.1.17 0.000000184 56.0
TLS2_k127_326210_12 Phosphopantetheine attachment site K02078 - - 0.00002219 50.0
TLS2_k127_326210_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 472.0
TLS2_k127_326210_3 Aminotransferase class-III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009093 464.0
TLS2_k127_326210_4 Peptidase S15 K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000591 372.0
TLS2_k127_326210_5 Male sterility protein K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000005851 273.0
TLS2_k127_326210_6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000003132 235.0
TLS2_k127_326210_7 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000000000000000000001298 164.0
TLS2_k127_326210_8 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000000003914 158.0
TLS2_k127_326210_9 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000002064 136.0
TLS2_k127_3334353_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1272.0
TLS2_k127_3334353_1 PFAM Type II secretion system protein E K02652 - - 1.869e-265 838.0
TLS2_k127_3334353_10 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 383.0
TLS2_k127_3334353_11 Flavin containing amine oxidoreductase K00274,K21639 - 1.4.3.25,1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 351.0
TLS2_k127_3334353_12 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007726 321.0
TLS2_k127_3334353_13 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 304.0
TLS2_k127_3334353_14 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 306.0
TLS2_k127_3334353_15 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000004881 274.0
TLS2_k127_3334353_16 MoaE protein K21142 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000101 270.0
TLS2_k127_3334353_17 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000001494 237.0
TLS2_k127_3334353_18 Pilus assembly protein K02662 - - 0.000000000000000000000000000000000000000000000000000000000000002126 228.0
TLS2_k127_3334353_19 outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000000000000000000000000000000000000000000000000000177 223.0
TLS2_k127_3334353_2 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 5.95e-253 796.0
TLS2_k127_3334353_20 Belongs to the HesB IscA family - - - 0.000000000000000000000000000000000000000000000000000000000007908 213.0
TLS2_k127_3334353_21 Pfam:N_methyl_2 - - - 0.0000000000000000000000000000000000000000006877 164.0
TLS2_k127_3334353_22 general secretion pathway protein - - - 0.000000000000000000000000000000000000001089 159.0
TLS2_k127_3334353_23 Pilus assembly protein K02662 - - 0.000000000000000000000000000000000000001797 157.0
TLS2_k127_3334353_24 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000007268 146.0
TLS2_k127_3334353_25 FR47-like protein K03789 - 2.3.1.128 0.0000000000000000000000000000000000006853 145.0
TLS2_k127_3334353_26 - - - - 0.00000000000000000000000000000174 128.0
TLS2_k127_3334353_27 Protein of unknown function (DUF3467) - - - 0.00000000000000000000000000008624 121.0
TLS2_k127_3334353_28 Hfq protein K03666 - - 0.000000000000000000000001509 107.0
TLS2_k127_3334353_29 - - - - 0.00000000000000000007033 95.0
TLS2_k127_3334353_3 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 609.0
TLS2_k127_3334353_30 - K02664 - - 0.00000000000000000024 96.0
TLS2_k127_3334353_31 energy transducer activity K02487,K03832,K06596 - - 0.000000000000004414 86.0
TLS2_k127_3334353_33 Belongs to the UPF0337 (CsbD) family - - - 0.000003062 52.0
TLS2_k127_3334353_4 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 467.0
TLS2_k127_3334353_5 Selenocysteine lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007765 465.0
TLS2_k127_3334353_6 PFAM Type II secretion system F domain K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 448.0
TLS2_k127_3334353_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 449.0
TLS2_k127_3334353_8 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 430.0
TLS2_k127_3334353_9 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 400.0
TLS2_k127_3364255_0 polysaccharide export K01991,K16552 - - 0.000000000000000000000000000000000000000000000000000000000000000009507 245.0
TLS2_k127_3364255_1 MFS/sugar transport protein - - - 0.0002074 54.0
TLS2_k127_3515553_0 Tetratricopeptide repeat - - - 1.085e-225 721.0
TLS2_k127_3515553_1 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 507.0
TLS2_k127_3515553_10 binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000000000000000000000000000001882 207.0
TLS2_k127_3515553_11 PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000000000000000000000000000004438 212.0
TLS2_k127_3515553_12 Ribosomal protein S18 K02963 - - 0.000000000000000000000000000000000000000001388 159.0
TLS2_k127_3515553_13 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000000000000000000000002175 156.0
TLS2_k127_3515553_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005534 501.0
TLS2_k127_3515553_3 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007312 329.0
TLS2_k127_3515553_4 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 318.0
TLS2_k127_3515553_5 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006849 287.0
TLS2_k127_3515553_6 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008209 285.0
TLS2_k127_3515553_7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008755 275.0
TLS2_k127_3515553_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000005804 234.0
TLS2_k127_3515553_9 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000000007439 224.0
TLS2_k127_3533973_0 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000006488 109.0
TLS2_k127_3533973_1 to Shigella flexneri,and Shigella flexneri 2A IS10 orf S0034 or Cp0027 SWALL Q9AFX7 (EMBL AF348706) (407 aa) fasta scores E() - - - 0.00003213 56.0
TLS2_k127_3534001_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 1.527e-285 891.0
TLS2_k127_3534001_1 secondary active p-aminobenzoyl-glutamate transmembrane transporter activity K12942 - - 2.626e-220 696.0
TLS2_k127_3534001_2 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000001322 209.0
TLS2_k127_3534001_4 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) K00382 GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019464,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045250,GO:0045252,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0097159,GO:0106077,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 0.0000000000004212 68.0
TLS2_k127_3534001_5 COG3209 Rhs family protein - - - 0.0000000000209 65.0
TLS2_k127_3535344_0 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008931 285.0
TLS2_k127_3535344_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 289.0
TLS2_k127_3535344_2 membrane transporter protein K07090 - - 0.00000000000000000007914 98.0
TLS2_k127_3535344_4 GGDEF domain - - - 0.0000008881 55.0
TLS2_k127_3575490_0 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009924 449.0
TLS2_k127_3575490_1 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002962 276.0
TLS2_k127_3580585_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006858 492.0
TLS2_k127_3580585_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 327.0
TLS2_k127_3580585_2 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 284.0
TLS2_k127_3580585_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001958 239.0
TLS2_k127_3580585_4 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000001464 182.0
TLS2_k127_3580585_5 Dioxygenase K00449 - 1.13.11.3 0.000000000000000000002192 102.0
TLS2_k127_3582219_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.543e-242 760.0
TLS2_k127_3584313_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000962 302.0
TLS2_k127_3584313_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009217 254.0
TLS2_k127_3584313_2 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000003217 147.0
TLS2_k127_3584313_3 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.000000000000000000000000000000005529 132.0
TLS2_k127_3584313_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000002211 79.0
TLS2_k127_3584313_5 Parallel beta-helix repeats - - - 0.0000009465 58.0
TLS2_k127_3584313_6 PD-(D/E)XK endonuclease - - - 0.0009216 50.0
TLS2_k127_3612050_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 7.511e-245 780.0
TLS2_k127_3612050_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 430.0
TLS2_k127_3612050_2 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000001585 151.0
TLS2_k127_3648663_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 397.0
TLS2_k127_3648663_1 Curli production assembly/transport component CsgG - - - 0.000000000006769 79.0
TLS2_k127_3713819_0 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 556.0
TLS2_k127_3713819_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 550.0
TLS2_k127_3713819_10 Putative transmembrane protein (PGPGW) - - - 0.0000009194 55.0
TLS2_k127_3713819_2 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 519.0
TLS2_k127_3713819_3 Cysteine-rich domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 332.0
TLS2_k127_3713819_4 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000006059 232.0
TLS2_k127_3713819_5 FAD linked oxidases, C-terminal domain K11472 - - 0.000000000000000000000000000000000000000000000000000003386 217.0
TLS2_k127_3713819_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000001498 151.0
TLS2_k127_3713819_8 manually curated - - - 0.000000003767 59.0
TLS2_k127_3713819_9 - - - - 0.0000002464 62.0
TLS2_k127_3758495_0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 350.0
TLS2_k127_3758495_1 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006416 336.0
TLS2_k127_3758495_2 - - - - 0.000000000000000000000000000000000444 134.0
TLS2_k127_3758495_3 Regulatory protein, FmdB - - - 0.0000000000000000000002184 100.0
TLS2_k127_3758495_5 - - - - 0.000003635 50.0
TLS2_k127_376132_0 Carboxypeptidase regulatory-like domain - - - 6.002e-253 814.0
TLS2_k127_376132_1 HD domain - - - 7.223e-196 629.0
TLS2_k127_379336_0 dead deah K03724 - - 0.0 1865.0
TLS2_k127_379336_1 Putative modulator of DNA gyrase K03568 - - 9.309e-251 782.0
TLS2_k127_379336_2 Putative modulator of DNA gyrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 534.0
TLS2_k127_379336_3 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 291.0
TLS2_k127_379336_4 PilZ domain - - - 0.000000000000000000004727 96.0
TLS2_k127_379336_5 phosphorelay signal transduction system - - - 0.0000000000000000001017 100.0
TLS2_k127_3797811_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 0.0 1294.0
TLS2_k127_3797811_1 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 443.0
TLS2_k127_3797811_10 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000005041 106.0
TLS2_k127_3797811_11 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000001293 63.0
TLS2_k127_3797811_2 Biotin-lipoyl like K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 362.0
TLS2_k127_3797811_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005129 340.0
TLS2_k127_3797811_4 PFAM Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000652 272.0
TLS2_k127_3797811_5 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000376 222.0
TLS2_k127_3797811_6 - - - - 0.0000000000000000000000000000000000000000000000000001486 208.0
TLS2_k127_3797811_8 - - - - 0.0000000000000000000000000000000000000008364 167.0
TLS2_k127_3797811_9 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000006948 150.0
TLS2_k127_3804557_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.618e-269 833.0
TLS2_k127_3804557_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 2.709e-267 830.0
TLS2_k127_3804557_10 Belongs to the ATPase B chain family K02109 - - 0.0000000000000000000000000000000000007918 145.0
TLS2_k127_3804557_11 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000159 130.0
TLS2_k127_3804557_12 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000000000000000000006818 125.0
TLS2_k127_3804557_13 - - - - 0.000000000000000007193 83.0
TLS2_k127_3804557_14 Domain of unknown function (DUF309) K09763 - - 0.000000000000001002 87.0
TLS2_k127_3804557_15 FHA domain - - - 0.000000000001296 74.0
TLS2_k127_3804557_2 serine threonine protein kinase K12132 - 2.7.11.1 3.401e-227 732.0
TLS2_k127_3804557_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 533.0
TLS2_k127_3804557_4 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009784 460.0
TLS2_k127_3804557_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 449.0
TLS2_k127_3804557_6 Protein phosphatase 2C K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 306.0
TLS2_k127_3804557_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000000000000000008015 170.0
TLS2_k127_3804557_8 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000001165 172.0
TLS2_k127_3804557_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000001604 162.0
TLS2_k127_3807192_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 7.07e-301 931.0
TLS2_k127_3807192_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 568.0
TLS2_k127_3807192_10 DinB family - - - 0.00000000000000000000000000000000000000000000000000007496 193.0
TLS2_k127_3807192_11 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000005643 166.0
TLS2_k127_3807192_12 YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the K09780 - - 0.0000000000000000000000000000000000001004 145.0
TLS2_k127_3807192_13 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K07516 - 1.1.1.35 0.000000000000000000000000000000000001886 141.0
TLS2_k127_3807192_16 GAF domain K08968 - 1.8.4.14 0.00000000000000000000008485 107.0
TLS2_k127_3807192_17 Helix-turn-helix domain K15539 - - 0.000000000000000000001402 105.0
TLS2_k127_3807192_2 Amidohydrolase family K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 514.0
TLS2_k127_3807192_3 DNA integration - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 406.0
TLS2_k127_3807192_4 PFAM DAHP synthetase I K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 366.0
TLS2_k127_3807192_5 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 367.0
TLS2_k127_3807192_6 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 367.0
TLS2_k127_3807192_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007566 359.0
TLS2_k127_3807192_8 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005997 342.0
TLS2_k127_3807192_9 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000000000000005438 224.0
TLS2_k127_3821508_0 Cytochrome c - - - 0.0 1039.0
TLS2_k127_3821508_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 439.0
TLS2_k127_3821508_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 362.0
TLS2_k127_3821508_3 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 294.0
TLS2_k127_3821508_4 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002855 243.0
TLS2_k127_3821508_5 deoxyhypusine monooxygenase activity K00627,K02160,K07402 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000001559 218.0
TLS2_k127_3821508_6 Cytochrome oxidase assembly protein K02259 - - 0.0000000000000000000000000000000000000000000000000001036 199.0
TLS2_k127_3821508_7 Protein of unknown function (DUF420) K08976 - - 0.000000000000000000000000000000000007592 152.0
TLS2_k127_3841339_0 PFAM Type II secretion system protein E K02454,K02504,K02652 - - 5.763e-303 942.0
TLS2_k127_3841339_1 TonB-dependent receptor K13735,K20276 - - 4.331e-257 831.0
TLS2_k127_3841339_10 phosphorelay signal transduction system K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 437.0
TLS2_k127_3841339_11 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 439.0
TLS2_k127_3841339_12 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 338.0
TLS2_k127_3841339_13 PAS PAC sensor signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002391 301.0
TLS2_k127_3841339_14 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001443 270.0
TLS2_k127_3841339_15 Transcriptional regulator K07013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002981 258.0
TLS2_k127_3841339_16 Putative adhesin - - - 0.00000000000000000000000000000000000000000000000000000000002488 218.0
TLS2_k127_3841339_17 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000001934 160.0
TLS2_k127_3841339_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000003131 161.0
TLS2_k127_3841339_19 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000001007 156.0
TLS2_k127_3841339_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000091 612.0
TLS2_k127_3841339_20 regulation of RNA biosynthetic process - - - 0.000000000000000000000000000000000000000127 164.0
TLS2_k127_3841339_21 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000006406 151.0
TLS2_k127_3841339_22 Cysteine-rich secretory protein family - - - 0.0000000000000000000000000000000004361 147.0
TLS2_k127_3841339_23 - - - - 0.00000000000000000000000000002623 118.0
TLS2_k127_3841339_24 - - - - 0.000000000000000000004947 100.0
TLS2_k127_3841339_3 PFAM Type II secretion system F domain K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009958 599.0
TLS2_k127_3841339_4 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004366 604.0
TLS2_k127_3841339_5 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 542.0
TLS2_k127_3841339_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 515.0
TLS2_k127_3841339_7 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 496.0
TLS2_k127_3841339_8 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 466.0
TLS2_k127_3841339_9 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 442.0
TLS2_k127_3854835_0 Belongs to the DegT DnrJ EryC1 family K13017 - 2.6.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 520.0
TLS2_k127_3854835_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 511.0
TLS2_k127_3854835_2 Undecaprenyl-phosphate galactose phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 347.0
TLS2_k127_3854835_3 COG1035 Coenzyme F420-reducing hydrogenase, beta subunit K00441 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000006391 261.0
TLS2_k127_3854835_4 O-acyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006634 249.0
TLS2_k127_3854835_5 Glycosyl transferase K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008418 261.0
TLS2_k127_3854835_6 Transcription termination factor nusG - - - 0.000000000000000000000000000000000000000002859 161.0
TLS2_k127_3878901_0 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006334 304.0
TLS2_k127_3878901_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0000000000000000000000000000000000000000000001218 186.0
TLS2_k127_3878901_2 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000001085 170.0
TLS2_k127_3878901_3 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000003186 171.0
TLS2_k127_3878901_4 Diacylglycerol kinase catalytic domain (presumed) - - - 0.00000000000000000000000000000000006066 150.0
TLS2_k127_3878901_5 - - - - 0.0000000000000000000000002602 117.0
TLS2_k127_3886999_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0 1082.0
TLS2_k127_3886999_1 Phosphoenolpyruvate carboxykinase K01610 - 4.1.1.49 2.967e-242 758.0
TLS2_k127_3886999_11 repeat-containing protein - - - 0.000000005767 68.0
TLS2_k127_3886999_2 Sigma factor PP2C-like phosphatases - - - 8.392e-206 647.0
TLS2_k127_3886999_3 COG1473 Metal-dependent amidase aminoacylase carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 574.0
TLS2_k127_3886999_4 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 462.0
TLS2_k127_3886999_5 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000118 271.0
TLS2_k127_3886999_6 C4-type zinc ribbon domain K07164 - - 0.00000000000000000000000000000000000000000000000000000000002953 214.0
TLS2_k127_3886999_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000000003288 205.0
TLS2_k127_3886999_8 - - - - 0.000000000000000000000000000000000000000000008855 165.0
TLS2_k127_3886999_9 - - - - 0.0000000000000000000000000001273 123.0
TLS2_k127_3968706_0 Protein of unknown function, DUF255 K06888 - - 8.185e-289 904.0
TLS2_k127_3968706_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 1.123e-207 652.0
TLS2_k127_3968706_10 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000000000007061 201.0
TLS2_k127_3968706_11 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000000000000000000000000000000000008563 184.0
TLS2_k127_3968706_12 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00001581 48.0
TLS2_k127_3968706_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 555.0
TLS2_k127_3968706_3 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 554.0
TLS2_k127_3968706_4 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 554.0
TLS2_k127_3968706_5 PFAM peptidase K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 452.0
TLS2_k127_3968706_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009686 365.0
TLS2_k127_3968706_7 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008856 354.0
TLS2_k127_3968706_8 - K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009044 291.0
TLS2_k127_3968706_9 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001019 290.0
TLS2_k127_396974_0 Cys/Met metabolism PLP-dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 544.0
TLS2_k127_396974_1 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 447.0
TLS2_k127_396974_2 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 397.0
TLS2_k127_396974_3 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 367.0
TLS2_k127_396974_4 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006266 359.0
TLS2_k127_396974_5 Hexapeptide repeat of succinyl-transferase K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008188 298.0
TLS2_k127_396974_6 Methyltransferase domain - - - 0.0000000000000000003677 97.0
TLS2_k127_3990289_0 Carboxyl transferase domain - - - 3.063e-298 923.0
TLS2_k127_3990289_1 Enoyl-CoA hydratase K01782,K01825 GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 0.0000000000000000000000000000000000000000000000000005491 192.0
TLS2_k127_3990289_2 Gaf domain K03832 - - 0.0000000000000000000000000000000000003538 161.0
TLS2_k127_3990289_3 HMGL-like K01640 - 4.1.3.4 0.000000000000000002018 85.0
TLS2_k127_3990289_4 - - - - 0.0000000001883 72.0
TLS2_k127_4034065_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 0.0 1614.0
TLS2_k127_4034065_1 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 626.0
TLS2_k127_4034065_10 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007547 396.0
TLS2_k127_4034065_11 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 397.0
TLS2_k127_4034065_12 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 373.0
TLS2_k127_4034065_13 HAD-superfamily hydrolase, subfamily IIB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 327.0
TLS2_k127_4034065_14 ferrochelatase activity K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0050896,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 302.0
TLS2_k127_4034065_15 Protein of unknown function (DUF3500) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 299.0
TLS2_k127_4034065_16 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001181 269.0
TLS2_k127_4034065_17 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001845 261.0
TLS2_k127_4034065_18 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000009135 241.0
TLS2_k127_4034065_19 oxidoreductase activity, acting on diphenols and related substances as donors K02636,K03886 - 1.10.9.1 0.000000000000000000000000000000000000000000000000000000000000000104 235.0
TLS2_k127_4034065_2 Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 602.0
TLS2_k127_4034065_20 YdjC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000155 231.0
TLS2_k127_4034065_21 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000003224 234.0
TLS2_k127_4034065_22 - - - - 0.00000000000000000000000000000000000000000000000000000000001717 212.0
TLS2_k127_4034065_23 alpha beta - - - 0.000000000000000000000000000000000000000000000000000000003111 207.0
TLS2_k127_4034065_24 B domain of TMEM189, localisation domain K20656 - - 0.0000000000000000000000000000000000000000000000000002504 198.0
TLS2_k127_4034065_25 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000001187 192.0
TLS2_k127_4034065_26 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000003308 160.0
TLS2_k127_4034065_27 Mycolic acid cyclopropane synthetase - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944 - 0.00000000000000000000000000000009611 136.0
TLS2_k127_4034065_28 PD-(D/E)XK endonuclease - - - 0.00000003851 60.0
TLS2_k127_4034065_3 glycosyl transferase group 1 K00754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 566.0
TLS2_k127_4034065_4 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006264 534.0
TLS2_k127_4034065_5 TIGRFAM Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005054 501.0
TLS2_k127_4034065_6 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 477.0
TLS2_k127_4034065_7 Histidine kinase K02478 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 459.0
TLS2_k127_4034065_8 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 454.0
TLS2_k127_4034065_9 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 432.0
TLS2_k127_4139861_0 TonB dependent receptor - - - 4.19e-221 732.0
TLS2_k127_4139861_1 Lysin motif K08307 - - 1.864e-219 698.0
TLS2_k127_4139861_2 Asparaginase K13051 - 3.4.19.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 411.0
TLS2_k127_4139861_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 295.0
TLS2_k127_4139861_4 CarD-like/TRCF domain K07736 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004961 261.0
TLS2_k127_4139861_5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007613 249.0
TLS2_k127_4139861_6 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000002268 224.0
TLS2_k127_4139861_7 Likely ribonuclease with RNase H fold. K07447 - - 0.00000000000000000000000000000000000000000003746 164.0
TLS2_k127_4139861_8 - - - - 0.00000000000000000000806 95.0
TLS2_k127_4154424_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000004616 212.0
TLS2_k127_4154424_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000003071 65.0
TLS2_k127_4185555_0 PFAM Aminotransferase class-III K01845 - 5.4.3.8 2.72e-199 631.0
TLS2_k127_4185555_1 polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000000000000000000005462 212.0
TLS2_k127_4185555_2 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000006835 153.0
TLS2_k127_4205526_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.015e-286 887.0
TLS2_k127_4205526_1 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 541.0
TLS2_k127_4205526_10 Plasmid stabilization system K19092 - - 0.000009455 53.0
TLS2_k127_4205526_2 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 359.0
TLS2_k127_4205526_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 337.0
TLS2_k127_4205526_4 - - - - 0.0000000000000000000000000000000000000000000000000005056 197.0
TLS2_k127_4205526_5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - - - 0.000000000000000000000004696 108.0
TLS2_k127_4205526_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000001933 90.0
TLS2_k127_4205526_8 PFAM Amidase - - - 0.0000000002727 63.0
TLS2_k127_4228465_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 8.153e-203 644.0
TLS2_k127_4228465_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 572.0
TLS2_k127_4228465_2 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 457.0
TLS2_k127_4228465_3 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 405.0
TLS2_k127_4228465_4 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 393.0
TLS2_k127_4228465_5 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002264 268.0
TLS2_k127_4228465_6 lyase activity - - - 0.0001444 55.0
TLS2_k127_4252806_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4e-323 997.0
TLS2_k127_4252806_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000001128 180.0
TLS2_k127_4252806_2 ATP-independent chaperone mediated protein folding - - - 0.0004547 51.0
TLS2_k127_4276188_0 lipopolysaccharide transport K09774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 625.0
TLS2_k127_4276188_1 RNA polymerase sigma-54 factor K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006161 593.0
TLS2_k127_4276188_2 ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 424.0
TLS2_k127_4276188_3 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 364.0
TLS2_k127_4276188_4 Ion transport protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002942 252.0
TLS2_k127_4276188_5 Ribosomal subunit interface protein K05808 - - 0.0000000000000000000000000000000000000000000000000000000000000000009682 234.0
TLS2_k127_4276188_6 SnoaL-like polyketide cyclase - - - 0.000000000009996 70.0
TLS2_k127_4281791_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 9.895e-230 720.0
TLS2_k127_4281791_1 formate dehydrogenase (NAD+) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001044 254.0
TLS2_k127_4298710_0 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000007177 213.0
TLS2_k127_4338985_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 373.0
TLS2_k127_4338985_1 PFAM membrane bound O-acyl transferase MBOAT family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 325.0
TLS2_k127_4365221_0 Pfam Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 509.0
TLS2_k127_4365221_1 Stage II sporulation protein E K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 512.0
TLS2_k127_4365221_10 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000004875 67.0
TLS2_k127_4365221_2 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 298.0
TLS2_k127_4365221_3 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000145 263.0
TLS2_k127_4365221_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001853 285.0
TLS2_k127_4365221_5 Response regulator, receiver - - - 0.0000000000000000000000000000000004355 142.0
TLS2_k127_4365221_6 - - - - 0.0000000000000000000000000000000008904 152.0
TLS2_k127_4365221_7 - - - - 0.0000000000000000000000003444 105.0
TLS2_k127_4365221_8 PEP-CTERM motif - - - 0.0000000000000006242 93.0
TLS2_k127_4365221_9 cheY-homologous receiver domain K07720 - - 0.000000005087 64.0
TLS2_k127_439375_0 aminoacyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006509 513.0
TLS2_k127_439375_1 AsmA family K07289 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 518.0
TLS2_k127_439375_10 AntiSigma factor - - - 0.000000000000000000000000000000000000000000000000000000000002342 220.0
TLS2_k127_439375_11 MFP subunit - - - 0.000000000000000000000000000000000000000000000000000001119 201.0
TLS2_k127_439375_12 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000002083 198.0
TLS2_k127_439375_13 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000006435 186.0
TLS2_k127_439375_15 - - - - 0.000000000000000000000000006018 117.0
TLS2_k127_439375_17 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0006358 51.0
TLS2_k127_439375_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 390.0
TLS2_k127_439375_3 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 355.0
TLS2_k127_439375_4 Phosphoesterase family K01114 - 3.1.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 353.0
TLS2_k127_439375_5 maltose O-acetyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 337.0
TLS2_k127_439375_6 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009684 305.0
TLS2_k127_439375_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000155 285.0
TLS2_k127_439375_8 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000000000001413 250.0
TLS2_k127_439375_9 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000003591 226.0
TLS2_k127_4416109_0 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 2.962e-255 809.0
TLS2_k127_4416109_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 520.0
TLS2_k127_4416109_10 Sulfatase - - - 0.000000000000000000000000000000000000000000002905 184.0
TLS2_k127_4416109_11 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.0000000000000000000000000000000000000001085 158.0
TLS2_k127_4416109_12 Zincin-like metallopeptidase K00930 - 2.7.2.8 0.0000000000000000000002137 103.0
TLS2_k127_4416109_13 - - - - 0.000000006512 61.0
TLS2_k127_4416109_2 PFAM Aminotransferase, class I K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 497.0
TLS2_k127_4416109_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 488.0
TLS2_k127_4416109_4 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005574 462.0
TLS2_k127_4416109_5 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 449.0
TLS2_k127_4416109_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 404.0
TLS2_k127_4416109_7 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 359.0
TLS2_k127_4416109_8 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 309.0
TLS2_k127_4416109_9 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000003763 191.0
TLS2_k127_4438086_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 1.184e-215 685.0
TLS2_k127_4438086_1 Aldehyde dehydrogenase family K04072,K15515 - 1.1.1.1,1.2.1.10,1.2.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 507.0
TLS2_k127_4438086_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002058 224.0
TLS2_k127_4438086_3 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000004062 213.0
TLS2_k127_4438086_4 ethanolamine catabolic process K04027 - - 0.0000000000000000000000000000000001878 137.0
TLS2_k127_4438086_5 RDD family - - - 0.000000000000000000000000000000001911 137.0
TLS2_k127_4438086_6 carboxylic ester hydrolase activity - - - 0.00000000498 65.0
TLS2_k127_4448678_0 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 1.765e-287 904.0
TLS2_k127_4448678_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 4.036e-211 668.0
TLS2_k127_4448678_10 Nucleic acid binding K03698 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 482.0
TLS2_k127_4448678_11 mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 477.0
TLS2_k127_4448678_12 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 466.0
TLS2_k127_4448678_13 Peptidase M48 K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 451.0
TLS2_k127_4448678_14 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 414.0
TLS2_k127_4448678_15 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 398.0
TLS2_k127_4448678_16 Phosphomannose isomerase type I K01809 - 5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 382.0
TLS2_k127_4448678_17 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 388.0
TLS2_k127_4448678_18 Type I phosphodiesterase / nucleotide pyrophosphatase K01113 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 365.0
TLS2_k127_4448678_19 Peptidylprolyl isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007778 346.0
TLS2_k127_4448678_2 Peptidase family M49 - - - 8.931e-203 647.0
TLS2_k127_4448678_20 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007734 325.0
TLS2_k127_4448678_21 Uncharacterized conserved protein (COG2071) K09166 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 308.0
TLS2_k127_4448678_22 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000003283 264.0
TLS2_k127_4448678_23 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000004222 262.0
TLS2_k127_4448678_24 Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005037 256.0
TLS2_k127_4448678_25 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000007791 237.0
TLS2_k127_4448678_26 COG1404 Subtilisin-like serine proteases - - - 0.000000000000000000000000000000000000000000000000000000000002899 229.0
TLS2_k127_4448678_27 PASTA domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000006799 210.0
TLS2_k127_4448678_28 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000000000000000000000000000000002709 205.0
TLS2_k127_4448678_29 Periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000000000000000000000004375 181.0
TLS2_k127_4448678_3 PFAM Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 617.0
TLS2_k127_4448678_30 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000000000000000002045 166.0
TLS2_k127_4448678_31 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000002009 173.0
TLS2_k127_4448678_32 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.000000000000000000000000000000000000001481 151.0
TLS2_k127_4448678_33 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000363 132.0
TLS2_k127_4448678_34 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000001963 124.0
TLS2_k127_4448678_35 COG2199 FOG GGDEF domain - - - 0.000000000000000000000000001831 129.0
TLS2_k127_4448678_36 Cupin 2, conserved barrel domain protein K16953,K19547 - 4.4.1.3,5.3.3.19 0.00000000000000000000000002217 115.0
TLS2_k127_4448678_37 cAMP biosynthetic process K03641,K08282,K12132 - 2.7.11.1 0.00000000000000000005924 104.0
TLS2_k127_4448678_38 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000004388 89.0
TLS2_k127_4448678_39 peptidyl-tyrosine sulfation - - - 0.000000003717 58.0
TLS2_k127_4448678_4 alpha beta alpha domain I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 597.0
TLS2_k127_4448678_40 Penicillinase repressor - - - 0.00001922 55.0
TLS2_k127_4448678_5 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 589.0
TLS2_k127_4448678_6 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 573.0
TLS2_k127_4448678_7 PFAM Aminotransferase, class I K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 571.0
TLS2_k127_4448678_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 531.0
TLS2_k127_4448678_9 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 498.0
TLS2_k127_4471210_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1243.0
TLS2_k127_4471210_1 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 497.0
TLS2_k127_4471210_2 Adenosine/AMP deaminase K01488,K18286 - 3.5.4.4,3.5.4.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007975 381.0
TLS2_k127_4471210_3 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 373.0
TLS2_k127_4471210_4 Yip1 domain - - - 0.000000000000000000000000000000000000000004326 165.0
TLS2_k127_4471210_5 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000001405 91.0
TLS2_k127_4474312_0 diguanylate cyclase K02030,K06950,K16923 - - 0.0 1077.0
TLS2_k127_4474312_1 Zinc carboxypeptidase - - - 2.66e-219 704.0
TLS2_k127_4474312_10 Diguanylate cyclase with PAS PAC and GAF sensors - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005695 383.0
TLS2_k127_4474312_11 MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005583 340.0
TLS2_k127_4474312_12 TIGRFAM TonB K03832 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 320.0
TLS2_k127_4474312_13 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 290.0
TLS2_k127_4474312_14 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003294 284.0
TLS2_k127_4474312_15 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000001509 220.0
TLS2_k127_4474312_16 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.00000000000000000000000000000000000000000000000000007058 192.0
TLS2_k127_4474312_17 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000000000000000000000000000000000000000000004199 184.0
TLS2_k127_4474312_18 Biotin-requiring enzyme - - - 0.000000000000000000000000000000000000000000000000285 182.0
TLS2_k127_4474312_19 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000000000000000000000000009536 133.0
TLS2_k127_4474312_2 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 1.032e-213 674.0
TLS2_k127_4474312_20 Protein of unknown function (DUF2393) - - - 0.0000000000000000000000001747 112.0
TLS2_k127_4474312_21 Preprotein translocase, YajC K03210 - - 0.000000000000000000000006676 104.0
TLS2_k127_4474312_22 Thioesterase K18700 - 3.1.2.29 0.000000000000001089 85.0
TLS2_k127_4474312_23 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 0.00000000008278 70.0
TLS2_k127_4474312_24 Protein of unknown function (DUF2393) - - - 0.0000000001344 72.0
TLS2_k127_4474312_3 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 2.111e-203 643.0
TLS2_k127_4474312_4 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 1.671e-202 638.0
TLS2_k127_4474312_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 4.678e-194 619.0
TLS2_k127_4474312_6 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 548.0
TLS2_k127_4474312_7 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 525.0
TLS2_k127_4474312_8 Large family of predicted nucleotide-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 521.0
TLS2_k127_4474312_9 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 401.0
TLS2_k127_4479330_0 TIGRFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001325 293.0
TLS2_k127_4479330_1 PFAM Redoxin - - - 0.0000000000000000000000000000000000000000000000009742 181.0
TLS2_k127_4479330_2 COG2217 Cation transport ATPase K17686 - 3.6.3.54 0.0000000000005832 68.0
TLS2_k127_4479330_3 Rhomboid family - - - 0.0000000009698 59.0
TLS2_k127_4484267_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 491.0
TLS2_k127_4484267_1 IstB-like ATP binding protein K02315 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005435 317.0
TLS2_k127_4484267_2 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000005774 163.0
TLS2_k127_4484267_3 Bacterial DNA-binding protein K03530 - - 0.00000000000000000000000000000000009356 147.0
TLS2_k127_4484267_4 - - - - 0.00000000000000000000000000000001262 135.0
TLS2_k127_4534851_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 317.0
TLS2_k127_4546343_0 4Fe-4S dicluster domain K00184 - - 0.0 1136.0
TLS2_k127_4546343_1 Polysulphide reductase, NrfD K00185 - - 4.479e-230 719.0
TLS2_k127_4546343_10 TIGRFAM TonB K03832 - - 0.0000000000000000000000000000000000000006248 162.0
TLS2_k127_4546343_11 Prokaryotic N-terminal methylation motif K02650,K02679,K10926,K12285 - - 0.000000000000000000000000000006718 126.0
TLS2_k127_4546343_12 - - - - 0.0000000000000007134 85.0
TLS2_k127_4546343_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 607.0
TLS2_k127_4546343_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 430.0
TLS2_k127_4546343_4 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005725 401.0
TLS2_k127_4546343_5 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 308.0
TLS2_k127_4546343_6 signal sequence binding K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 299.0
TLS2_k127_4546343_7 Protein of unknown function (DUF3341) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002373 254.0
TLS2_k127_4546343_8 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000001915 226.0
TLS2_k127_4546343_9 - - - - 0.0000000000000000000000000000000000000000000001406 177.0
TLS2_k127_4583097_0 AIR synthase related protein, C-terminal domain K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007673 356.0
TLS2_k127_4583097_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 314.0
TLS2_k127_4583097_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 308.0
TLS2_k127_4583097_3 Cytochrome C biogenesis protein K06196,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002082 282.0
TLS2_k127_4583097_4 Fibronectin type 3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009689 252.0
TLS2_k127_4583097_5 Glutathione peroxidase K02199 - - 0.0000000000000000000000000000000000000005146 161.0
TLS2_k127_4583097_6 Disulphide bond corrector protein DsbC - - - 0.0000000000000000000000000000000000002831 149.0
TLS2_k127_4583097_7 - - - - 0.00000000000000000000000000000001365 131.0
TLS2_k127_4583097_8 - - - - 0.00000000000000000000000000000009311 130.0
TLS2_k127_4593436_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 493.0
TLS2_k127_4593436_1 domain protein K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 309.0
TLS2_k127_4611441_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 381.0
TLS2_k127_4611441_1 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000003576 164.0
TLS2_k127_4611441_2 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000004251 131.0
TLS2_k127_4615357_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 331.0
TLS2_k127_4615357_2 Methyltransferase type 11 K20444 - - 0.00000000000000000000000000000001154 138.0
TLS2_k127_4615357_3 Glycosyl transferases group 1 - - - 0.00000000000000000000001363 115.0
TLS2_k127_4615357_4 dTDP biosynthetic process K00560,K00943 - 2.1.1.45,2.7.4.9 0.0000000000000000000871 102.0
TLS2_k127_4615357_5 CDP-alcohol phosphatidyltransferase - - - 0.00000003835 65.0
TLS2_k127_462676_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005368 404.0
TLS2_k127_462676_1 Required for morphogenesis under gluconeogenic growth conditions - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003462 406.0
TLS2_k127_462676_2 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 387.0
TLS2_k127_462676_3 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000001813 237.0
TLS2_k127_462676_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000355 226.0
TLS2_k127_462676_5 TIGRFAM Carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000009433 193.0
TLS2_k127_462676_6 Protein of unknown function with PCYCGC motif - - - 0.00000000000000000000000000000000000000000007643 167.0
TLS2_k127_462676_7 negative regulation of transcription, DNA-templated K10947 - - 0.000000000000000000000000000001853 124.0
TLS2_k127_462676_8 glyoxalase III activity - - - 0.0000000000000000000000000006231 128.0
TLS2_k127_4634955_0 HELICc2 K03722 - 3.6.4.12 7.943e-259 813.0
TLS2_k127_4634955_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 3.379e-215 676.0
TLS2_k127_4634955_10 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000005635 199.0
TLS2_k127_4634955_11 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000002547 98.0
TLS2_k127_4634955_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 3.146e-194 617.0
TLS2_k127_4634955_3 TIGRFAM molybdenum cofactor synthesis K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 400.0
TLS2_k127_4634955_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 362.0
TLS2_k127_4634955_5 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 321.0
TLS2_k127_4634955_6 Subtilase family K17734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008165 295.0
TLS2_k127_4634955_7 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000007106 208.0
TLS2_k127_4634955_8 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000006346 200.0
TLS2_k127_4634955_9 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000005044 191.0
TLS2_k127_4662676_0 Dehydrogenase E1 component K11381 - 1.2.4.4 0.0 1124.0
TLS2_k127_4662676_1 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000001908 81.0
TLS2_k127_4670154_0 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 380.0
TLS2_k127_4670154_1 Protein of unknown function (DUF1385) - - - 0.00000000000000000000000000000007329 129.0
TLS2_k127_4670154_2 AIR synthase related protein, C-terminal domain K01008 - 2.7.9.3 0.0000000000000000000000007886 105.0
TLS2_k127_4670154_3 hyperosmotic response K04065 - - 0.000000008371 68.0
TLS2_k127_4680315_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000074 537.0
TLS2_k127_4680315_1 TIGRFAM amidase, hydantoinase carbamoylase K02083,K06016,K18151 - 3.5.1.116,3.5.1.6,3.5.1.87,3.5.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 504.0
TLS2_k127_4680315_2 Protein of unknown function (DUF1009) K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 381.0
TLS2_k127_4680315_3 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004513 383.0
TLS2_k127_4680315_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000001356 208.0
TLS2_k127_4680315_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000007314 171.0
TLS2_k127_4680315_6 DinB superfamily - - - 0.00000000000000000000000000000000000000004722 161.0
TLS2_k127_4680315_7 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000002477 110.0
TLS2_k127_4680315_8 TIGRFAM Addiction module antidote protein, HigA K21498 - - 0.000000000000000000000002495 105.0
TLS2_k127_4680315_9 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000005347 96.0
TLS2_k127_4709_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1030.0
TLS2_k127_4709_1 copper-translocating P-type ATPase K17686 - 3.6.3.54 0.0 1024.0
TLS2_k127_4709_10 Immunity protein 53 - - - 0.0000000000000000000000001057 112.0
TLS2_k127_4709_11 - - - - 0.0000000000000000005606 88.0
TLS2_k127_4709_12 - - - - 0.000000000000001002 87.0
TLS2_k127_4709_13 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000007062 65.0
TLS2_k127_4709_2 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 486.0
TLS2_k127_4709_3 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 405.0
TLS2_k127_4709_4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 310.0
TLS2_k127_4709_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 297.0
TLS2_k127_4709_6 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003536 261.0
TLS2_k127_4709_7 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000001663 241.0
TLS2_k127_4709_8 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000003533 213.0
TLS2_k127_4709_9 GAF domain - - - 0.000000000000000000000000000000000000000000000000653 184.0
TLS2_k127_4735301_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 2.508e-297 933.0
TLS2_k127_4735301_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 9.836e-230 720.0
TLS2_k127_4735301_10 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000003141 255.0
TLS2_k127_4735301_11 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000000000001357 211.0
TLS2_k127_4735301_12 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000006346 200.0
TLS2_k127_4735301_13 - - - - 0.000000000000000000000000000000000000000000000000000001447 211.0
TLS2_k127_4735301_14 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000003805 181.0
TLS2_k127_4735301_15 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000000000000015 183.0
TLS2_k127_4735301_16 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000001838 182.0
TLS2_k127_4735301_17 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000000000000000000000000005685 166.0
TLS2_k127_4735301_18 Hfq protein - - - 0.000000000000000000000000000000000000000000008194 168.0
TLS2_k127_4735301_19 MerR HTH family regulatory protein K13640 - - 0.000000000000000000000000000000001391 131.0
TLS2_k127_4735301_2 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 458.0
TLS2_k127_4735301_20 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000000000001775 128.0
TLS2_k127_4735301_23 Belongs to the UPF0109 family K06960 - - 0.00000000000000000001027 94.0
TLS2_k127_4735301_24 - - - - 0.00000000002171 71.0
TLS2_k127_4735301_25 - - - - 0.0000000001102 65.0
TLS2_k127_4735301_3 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000805 431.0
TLS2_k127_4735301_4 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006285 365.0
TLS2_k127_4735301_5 dUTPase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 352.0
TLS2_k127_4735301_6 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 337.0
TLS2_k127_4735301_7 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004167 319.0
TLS2_k127_4735301_8 GlcNAc-PI de-N-acetylase K22135 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 286.0
TLS2_k127_4735301_9 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001164 278.0
TLS2_k127_4810643_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 2.164e-283 884.0
TLS2_k127_4810643_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 3.166e-207 650.0
TLS2_k127_4810643_10 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 294.0
TLS2_k127_4810643_11 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004948 264.0
TLS2_k127_4810643_12 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000009573 210.0
TLS2_k127_4810643_13 - - - - 0.000000000000000000000000000000000000000000000004475 183.0
TLS2_k127_4810643_14 Putative zinc-finger - - - 0.0000000000000000000000000000000000000000000006373 175.0
TLS2_k127_4810643_15 Protein of unknown function (DUF507) K09804 - - 0.0000000000000000000000000000000000005935 145.0
TLS2_k127_4810643_16 Cold shock protein domain K03704 - - 0.000000000000000000000000000000000007736 136.0
TLS2_k127_4810643_17 - - - - 0.000000000000000000444 93.0
TLS2_k127_4810643_2 OPT oligopeptide transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007941 407.0
TLS2_k127_4810643_4 Phosphoesterase family K01114 - 3.1.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004203 386.0
TLS2_k127_4810643_5 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 353.0
TLS2_k127_4810643_6 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 333.0
TLS2_k127_4810643_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008303 326.0
TLS2_k127_4810643_8 HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007098 307.0
TLS2_k127_4810643_9 Putative adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 312.0
TLS2_k127_4829639_0 PFAM Magnesium chelatase, ChlI subunit K07391 - - 2.068e-263 820.0
TLS2_k127_4833994_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 4.947e-301 929.0
TLS2_k127_4833994_1 Oligoendopeptidase f - - - 6.132e-252 796.0
TLS2_k127_4833994_10 PFAM peptidase M48 Ste24p - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 312.0
TLS2_k127_4833994_11 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 314.0
TLS2_k127_4833994_12 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000002849 244.0
TLS2_k127_4833994_13 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000002925 217.0
TLS2_k127_4833994_14 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000007846 199.0
TLS2_k127_4833994_15 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000001589 159.0
TLS2_k127_4833994_16 - - - - 0.000000000000000000004116 97.0
TLS2_k127_4833994_17 PFAM Glutaredoxin-like domain (DUF836) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000003344 72.0
TLS2_k127_4833994_18 TIGRFAM TonB K03832 - - 0.000000001393 69.0
TLS2_k127_4833994_19 ABC-2 family transporter protein K01992 - - 0.00000007173 63.0
TLS2_k127_4833994_2 Amidohydrolase family - - - 2.308e-214 679.0
TLS2_k127_4833994_3 AMP-binding enzyme C-terminal domain - - - 3.663e-212 671.0
TLS2_k127_4833994_4 Uncharacterized conserved protein (DUF2075) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 525.0
TLS2_k127_4833994_5 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000676 403.0
TLS2_k127_4833994_6 PFAM peptidase M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 396.0
TLS2_k127_4833994_7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 371.0
TLS2_k127_4833994_8 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 330.0
TLS2_k127_4833994_9 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 324.0
TLS2_k127_4868350_0 PLD-like domain K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006869 490.0
TLS2_k127_4868350_1 PFAM Sodium sulphate symporter K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 490.0
TLS2_k127_4868350_2 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 304.0
TLS2_k127_4868350_3 F420-0:Gamma-glutamyl ligase K12234 GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000002174 274.0
TLS2_k127_4868350_4 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000007483 130.0
TLS2_k127_4868350_5 TIGRFAM LPPG domain K11212 - 2.7.8.28 0.0000000000000001174 83.0
TLS2_k127_4876844_0 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 341.0
TLS2_k127_4876844_1 - - - - 0.000000000000004136 79.0
TLS2_k127_4886599_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1090.0
TLS2_k127_4886599_1 Histidine kinase K02482,K03557 - 2.7.13.3 3.046e-298 952.0
TLS2_k127_4886599_10 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 461.0
TLS2_k127_4886599_11 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 402.0
TLS2_k127_4886599_12 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005002 355.0
TLS2_k127_4886599_13 PFAM TonB-dependent Receptor Plug - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 359.0
TLS2_k127_4886599_14 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 321.0
TLS2_k127_4886599_15 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 302.0
TLS2_k127_4886599_16 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000001269 257.0
TLS2_k127_4886599_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001966 254.0
TLS2_k127_4886599_18 multi-organism process K03195 - - 0.0000000000000000000000000000000000000000000000000000000000000008045 227.0
TLS2_k127_4886599_19 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000006569 196.0
TLS2_k127_4886599_2 Protein of unknown function (DUF1343) - - - 3.411e-289 908.0
TLS2_k127_4886599_20 cellular response to heat K09807 - - 0.000000000000000000000000000000000000000000000000001182 194.0
TLS2_k127_4886599_21 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000249 181.0
TLS2_k127_4886599_22 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000191 151.0
TLS2_k127_4886599_23 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000000003098 144.0
TLS2_k127_4886599_25 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000003743 136.0
TLS2_k127_4886599_26 Pkd domain containing protein - - - 0.00000000000000000000005149 115.0
TLS2_k127_4886599_27 Type IV pilus biogenesis stability protein PilW - - - 0.00000000000002689 82.0
TLS2_k127_4886599_3 TonB-dependent receptor K13735,K20276 - - 8.168e-232 757.0
TLS2_k127_4886599_4 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 6.323e-206 676.0
TLS2_k127_4886599_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 8.284e-195 623.0
TLS2_k127_4886599_6 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 580.0
TLS2_k127_4886599_7 Glycosyl hydrolases family 15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 530.0
TLS2_k127_4886599_8 Putative glucoamylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 515.0
TLS2_k127_4886599_9 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 526.0
TLS2_k127_4910468_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1005.0
TLS2_k127_4910468_1 radical SAM domain protein - - - 5.49e-279 872.0
TLS2_k127_4910468_10 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001325 278.0
TLS2_k127_4910468_11 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000007593 222.0
TLS2_k127_4910468_12 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000000000009477 234.0
TLS2_k127_4910468_13 Outer membrane protein (OmpH-like) K06142 - - 0.00000000000000000000000000000000002624 147.0
TLS2_k127_4910468_14 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000002016 138.0
TLS2_k127_4910468_15 - - - - 0.00000000000000000000000000000009528 134.0
TLS2_k127_4910468_16 - - - - 0.0000000000000000000000000001531 121.0
TLS2_k127_4910468_17 - - - - 0.0000000000000000000000403 104.0
TLS2_k127_4910468_18 - - - - 0.0000000000000008151 86.0
TLS2_k127_4910468_19 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000001519 71.0
TLS2_k127_4910468_2 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 3.014e-232 722.0
TLS2_k127_4910468_20 Immunity protein 26 - - - 0.0009165 42.0
TLS2_k127_4910468_3 TIGRFAM malto-oligosyltrehalose trehalohydrolase K01236 - 3.2.1.141 5.181e-219 703.0
TLS2_k127_4910468_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000909 543.0
TLS2_k127_4910468_5 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005647 496.0
TLS2_k127_4910468_6 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006157 425.0
TLS2_k127_4910468_7 Peptidase dimerisation domain K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 408.0
TLS2_k127_4910468_8 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 373.0
TLS2_k127_4910468_9 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 347.0
TLS2_k127_4973643_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1265.0
TLS2_k127_4973643_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 2.007e-259 806.0
TLS2_k127_4973643_10 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 330.0
TLS2_k127_4973643_11 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 317.0
TLS2_k127_4973643_12 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000001509 228.0
TLS2_k127_4973643_13 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000004798 186.0
TLS2_k127_4973643_14 Sporulation and spore germination - - - 0.0000000000000000000000000000000000002383 150.0
TLS2_k127_4973643_15 GYD domain - - - 0.0000000000000000000000000000000000006671 142.0
TLS2_k127_4973643_16 Protein of unknown function (DUF1579) - - - 0.0000000000000000000000000000000008135 139.0
TLS2_k127_4973643_17 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000001052 112.0
TLS2_k127_4973643_18 - - - - 0.00000000000000000000001855 108.0
TLS2_k127_4973643_19 Pfam Activator of Hsp90 ATPase - - - 0.00000000000000000008179 101.0
TLS2_k127_4973643_2 Cys/Met metabolism PLP-dependent enzyme K01739,K01758,K01760,K17217 - 2.5.1.48,4.4.1.1,4.4.1.2,4.4.1.8 2.713e-195 614.0
TLS2_k127_4973643_20 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - - 0.0000005593 55.0
TLS2_k127_4973643_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 608.0
TLS2_k127_4973643_4 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K01635 - 4.1.2.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 502.0
TLS2_k127_4973643_5 PFAM Uncharacterised conserved protein UCP033563 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 443.0
TLS2_k127_4973643_6 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004177 435.0
TLS2_k127_4973643_7 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 405.0
TLS2_k127_4973643_8 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 372.0
TLS2_k127_4973643_9 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 354.0
TLS2_k127_4989502_0 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 355.0
TLS2_k127_4989502_1 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000441 285.0
TLS2_k127_4989502_2 PFAM Cupin 2 conserved barrel domain protein K05913 - 1.13.11.41 0.000000000000000000000000000000000000000003459 160.0
TLS2_k127_4989502_3 lactoylglutathione lyase activity - - - 0.000000000000000000000002928 113.0
TLS2_k127_498997_0 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000636 562.0
TLS2_k127_498997_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 338.0
TLS2_k127_498997_2 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000001588 169.0
TLS2_k127_498997_3 Bacterial Ig-like domain (group 3) - - - 0.00000001556 67.0
TLS2_k127_498997_4 Fibronectin type 3 domain - - - 0.0001203 54.0
TLS2_k127_4993533_0 Belongs to the PstS family K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 397.0
TLS2_k127_4993533_1 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104,K03325,K03741,K03892,K18701 - 1.20.4.1,2.8.4.2,3.1.3.48 0.00000000000000000000000000000000000000000000000000006051 190.0
TLS2_k127_4993533_2 negative regulation of phosphate transmembrane transport K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000001384 105.0
TLS2_k127_5028431_0 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000009965 256.0
TLS2_k127_5028431_1 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000001099 132.0
TLS2_k127_5028431_2 slime layer polysaccharide biosynthetic process - - - 0.00000000000000000001908 94.0
TLS2_k127_504999_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 494.0
TLS2_k127_504999_1 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 516.0
TLS2_k127_504999_2 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 403.0
TLS2_k127_504999_3 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 311.0
TLS2_k127_504999_4 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001383 268.0
TLS2_k127_504999_6 Protein of unknown function (DUF3106) - - - 0.0000000000000000001775 98.0
TLS2_k127_504999_7 integral membrane protein - - - 0.00000000000001989 83.0
TLS2_k127_5069857_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 402.0
TLS2_k127_5069857_1 Lactonase, 7-bladed beta-propeller - - - 0.0000000000006644 80.0
TLS2_k127_5069857_2 Peptidase family M28 - - - 0.0000000000009634 76.0
TLS2_k127_5078288_0 TIGRFAM isocitrate dehydrogenase, NADP-dependent K00031 - 1.1.1.42 9.036e-247 768.0
TLS2_k127_5078288_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 537.0
TLS2_k127_5078288_2 Sodium/hydrogen exchanger family K11105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 522.0
TLS2_k127_5078288_3 Glutamate-ammonia ligase adenylyltransferase K00982 - 2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 459.0
TLS2_k127_5078288_4 DinB superfamily - - - 0.00000000000000000000000000001909 124.0
TLS2_k127_5121216_0 pfam abc K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 425.0
TLS2_k127_5121216_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000632 113.0
TLS2_k127_5121216_2 Diguanylate cyclase, GGDEF domain - - - 0.000003396 49.0
TLS2_k127_5144113_0 TonB-dependent Receptor Plug Domain K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 591.0
TLS2_k127_5144113_1 ethanolamine catabolic process K04027 - - 0.00000000000000000000000000000000000000000958 154.0
TLS2_k127_5144113_2 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - 0.000000000000000000000000000005569 121.0
TLS2_k127_5144113_3 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028,K08697 - - 0.00000000000000000000000001731 111.0
TLS2_k127_5144113_4 Ethanolamine utilisation protein EutN/carboxysome K04028 - - 0.00000000000000009718 83.0
TLS2_k127_5144447_0 Permease, YjgP YjgQ - - - 4.616e-272 859.0
TLS2_k127_5144447_1 ABC transporter, transmembrane K18889 - - 4.649e-255 798.0
TLS2_k127_5144447_10 Peptidase, M16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006513 488.0
TLS2_k127_5144447_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 471.0
TLS2_k127_5144447_12 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 491.0
TLS2_k127_5144447_13 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 449.0
TLS2_k127_5144447_14 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 433.0
TLS2_k127_5144447_15 Transcriptional regulator, LysR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 400.0
TLS2_k127_5144447_16 PFAM M42 glutamyl aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 371.0
TLS2_k127_5144447_17 SMART band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 364.0
TLS2_k127_5144447_18 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 341.0
TLS2_k127_5144447_19 3-isopropylmalate dehydratase activity K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002321 278.0
TLS2_k127_5144447_2 Belongs to the UbiD family K03182 - 4.1.1.98 3.905e-253 812.0
TLS2_k127_5144447_20 Glucose inhibited division protein A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005249 284.0
TLS2_k127_5144447_21 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003153 245.0
TLS2_k127_5144447_22 - - - - 0.000000000000000000000000000000000000000000000000000000000004145 222.0
TLS2_k127_5144447_23 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000004537 216.0
TLS2_k127_5144447_24 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000002104 205.0
TLS2_k127_5144447_25 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000000000000000001198 190.0
TLS2_k127_5144447_27 methyltransferase - - - 0.000000000000000000000000000000000000007461 158.0
TLS2_k127_5144447_28 Sporulation related domain - - - 0.0000000000000000000000000000000000005104 152.0
TLS2_k127_5144447_29 - - - - 0.000000000000000000000000000001737 129.0
TLS2_k127_5144447_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 1.799e-250 782.0
TLS2_k127_5144447_30 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000006671 113.0
TLS2_k127_5144447_31 Glyoxalase-like domain K01759 GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 0.0000000000000118 81.0
TLS2_k127_5144447_32 Redoxin - - - 0.000000000005269 70.0
TLS2_k127_5144447_33 - - - - 0.000004639 51.0
TLS2_k127_5144447_34 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.00003364 46.0
TLS2_k127_5144447_35 Alkyl hydroperoxide reductase - - - 0.0006817 46.0
TLS2_k127_5144447_4 metalloendopeptidase activity K01283 - 3.4.15.1 2.31e-247 777.0
TLS2_k127_5144447_5 3-isopropylmalate dehydratase activity K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 2.03e-226 719.0
TLS2_k127_5144447_6 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 2.132e-213 674.0
TLS2_k127_5144447_7 Insulinase (Peptidase family M16) - - - 1.201e-202 642.0
TLS2_k127_5144447_8 Dehydrogenase K00101,K00467 - 1.1.2.3,1.13.12.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 509.0
TLS2_k127_5144447_9 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 502.0
TLS2_k127_5163086_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582,K16898 - 3.1.11.5,3.6.4.12 5.36e-271 876.0
TLS2_k127_5163086_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 9.019e-238 756.0
TLS2_k127_5163086_2 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007713 593.0
TLS2_k127_5163086_3 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784,K12448 - 5.1.3.2,5.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009317 339.0
TLS2_k127_5163086_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000008342 192.0
TLS2_k127_5163086_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.000000000000000000000000000000000000000000000000009947 189.0
TLS2_k127_5163086_6 - - - - 0.00000000000000000000000002138 115.0
TLS2_k127_520716_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1073.0
TLS2_k127_520716_1 Bacterial regulatory protein, Fis family - - - 1.39e-228 717.0
TLS2_k127_520716_10 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001636 271.0
TLS2_k127_520716_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000002138 241.0
TLS2_k127_520716_12 Serine Threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000001133 201.0
TLS2_k127_520716_13 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000000000146 168.0
TLS2_k127_520716_14 Predicted membrane protein (DUF2306) - - - 0.0000000000000000000000000000000000000000005426 165.0
TLS2_k127_520716_16 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000003455 148.0
TLS2_k127_520716_17 CBS domain - - - 0.00000000000000000000000000000003365 137.0
TLS2_k127_520716_18 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000459 116.0
TLS2_k127_520716_19 cheY-homologous receiver domain - - - 0.0000000000000000000001417 113.0
TLS2_k127_520716_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 3.942e-226 706.0
TLS2_k127_520716_20 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000000001869 96.0
TLS2_k127_520716_21 metallopeptidase activity K07404 - 3.1.1.31 0.000000000000013 86.0
TLS2_k127_520716_24 Pyridoxamine 5'-phosphate oxidase - - - 0.0000005633 57.0
TLS2_k127_520716_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 5.323e-208 659.0
TLS2_k127_520716_4 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 507.0
TLS2_k127_520716_5 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 491.0
TLS2_k127_520716_6 Gas vesicle - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 344.0
TLS2_k127_520716_7 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 315.0
TLS2_k127_520716_9 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004243 278.0
TLS2_k127_5239350_0 Involved in the tonB-independent uptake of proteins - - - 4.918e-309 972.0
TLS2_k127_5239350_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.302e-308 967.0
TLS2_k127_5239350_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002029 266.0
TLS2_k127_5239350_3 Cold shock protein domain K03704 - - 0.0000000000000000000000006731 111.0
TLS2_k127_5289046_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.381e-257 795.0
TLS2_k127_5289046_1 3-isopropylmalate dehydratase activity K01681,K01703,K01704,K17749 - 4.2.1.3,4.2.1.33,4.2.1.35 6.412e-240 758.0
TLS2_k127_5289046_2 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 367.0
TLS2_k127_5289046_3 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 349.0
TLS2_k127_5289046_4 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 337.0
TLS2_k127_5289046_5 4Fe-4S dicluster domain K05524 - - 0.000000000000000000000000000000000000000000000000108 177.0
TLS2_k127_5289046_6 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000008654 182.0
TLS2_k127_5321288_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006917 481.0
TLS2_k127_5321288_1 Dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000766 424.0
TLS2_k127_5321288_10 Domain of unknown function (DUF1844) - - - 0.00000000000000000000000003473 122.0
TLS2_k127_5321288_11 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.00000000000000000000000008455 122.0
TLS2_k127_5321288_12 - - - - 0.0000000000000004671 80.0
TLS2_k127_5321288_13 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000001151 65.0
TLS2_k127_5321288_14 - - - - 0.000000001271 66.0
TLS2_k127_5321288_2 major pilin protein fima - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 397.0
TLS2_k127_5321288_3 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 387.0
TLS2_k127_5321288_4 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 370.0
TLS2_k127_5321288_5 The glycine cleavage system catalyzes the degradation of glycine K00605,K06980,K22086 - 1.5.99.5,2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 355.0
TLS2_k127_5321288_6 Zn peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009152 336.0
TLS2_k127_5321288_7 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000008515 263.0
TLS2_k127_5321288_8 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000000000000002264 159.0
TLS2_k127_5321288_9 chaperone-mediated protein folding K11935 - - 0.000000000000000000000000002761 122.0
TLS2_k127_5363336_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 571.0
TLS2_k127_5363336_1 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 516.0
TLS2_k127_5363336_10 COG0454 Histone acetyltransferase HPA2 and related - - - 0.0000000000000000000000000000000000000000000000001266 186.0
TLS2_k127_5363336_11 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000001099 168.0
TLS2_k127_5363336_12 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000001705 159.0
TLS2_k127_5363336_13 Pfam:N_methyl_2 - - - 0.0000000000000000000000000000000003212 140.0
TLS2_k127_5363336_14 - - - - 0.00000000000000000000000000000000473 140.0
TLS2_k127_5363336_15 Ribosomal L32p protein family K02911 - - 0.00000000000000000000000000002381 117.0
TLS2_k127_5363336_16 transmembrane transport - - - 0.0000000000000000000001584 106.0
TLS2_k127_5363336_2 Glycosyl transferase family 2 K21349 - 2.4.1.268 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 512.0
TLS2_k127_5363336_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 438.0
TLS2_k127_5363336_4 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008372 420.0
TLS2_k127_5363336_5 COG0454 Histone acetyltransferase HPA2 and related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007047 351.0
TLS2_k127_5363336_6 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 329.0
TLS2_k127_5363336_7 peptidase S8 and S53, subtilisin, kexin, sedolisin K20754 - 3.4.21.111 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004862 279.0
TLS2_k127_5363336_8 haloacid dehalogenase-like hydrolase K05947,K07026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 2.4.1.217,3.1.3.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000003608 277.0
TLS2_k127_5363336_9 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000000000000000000000000000003584 208.0
TLS2_k127_5411812_0 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000009982 261.0
TLS2_k127_5411812_1 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000000000005393 176.0
TLS2_k127_5460023_0 peroxiredoxin, OsmC subfamily K04063 - - 0.00000000000000000000000000000000000000000000000000003523 193.0
TLS2_k127_5460023_1 - - - - 0.000000000000000000000000000000000000000000000006497 185.0
TLS2_k127_5460023_2 ketosteroid isomerase - - - 0.0000000000000000000000000000000003087 135.0
TLS2_k127_5460023_3 - - - - 0.00000000000000000000001401 111.0
TLS2_k127_5460023_4 - - - - 0.0000000000000000008908 92.0
TLS2_k127_5460023_5 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000004493 79.0
TLS2_k127_5460023_6 PD-(D/E)XK endonuclease - - - 0.0000007656 60.0
TLS2_k127_5475667_0 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 461.0
TLS2_k127_5475667_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 396.0
TLS2_k127_5475667_2 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000002148 194.0
TLS2_k127_5492006_0 Radical SAM - - - 0.0 1261.0
TLS2_k127_5492006_1 glycolate transport K14393 - - 4.672e-221 696.0
TLS2_k127_5492006_2 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 490.0
TLS2_k127_5492006_3 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006164 309.0
TLS2_k127_5492006_4 CDP-alcohol phosphatidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000138 252.0
TLS2_k127_5492006_5 Protein of unknown function, DUF485 - - - 0.0000000000000000000000000000000004233 134.0
TLS2_k127_5492006_6 GtrA-like protein - - - 0.000000000000000001753 94.0
TLS2_k127_551138_0 signal transduction histidine kinase - - - 7.994e-280 880.0
TLS2_k127_551138_1 Two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 1.08e-232 727.0
TLS2_k127_551138_10 endonuclease III - - - 0.00000000000000000000000000000001147 132.0
TLS2_k127_551138_11 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000001015 128.0
TLS2_k127_551138_12 Polymer-forming cytoskeletal - - - 0.00000002553 65.0
TLS2_k127_551138_2 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 526.0
TLS2_k127_551138_3 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 452.0
TLS2_k127_551138_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 452.0
TLS2_k127_551138_5 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 398.0
TLS2_k127_551138_6 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 343.0
TLS2_k127_551138_7 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000007026 175.0
TLS2_k127_551138_8 - - - - 0.000000000000000000000000000000000000000002385 158.0
TLS2_k127_551138_9 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000007219 148.0
TLS2_k127_5526790_0 PFAM Integrase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 444.0
TLS2_k127_5526790_1 PFAM transposase IS3 IS911 family protein - - - 0.000000000000000000000000000000009087 129.0
TLS2_k127_5632397_0 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 484.0
TLS2_k127_5632397_1 Protein involved in outer membrane biogenesis K07289,K07290 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 460.0
TLS2_k127_5632397_2 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009232 334.0
TLS2_k127_5632397_3 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000000000000000002321 148.0
TLS2_k127_5632397_4 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.00000005626 54.0
TLS2_k127_5652667_0 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000001961 177.0
TLS2_k127_5652667_1 cAMP biosynthetic process K03641,K08282,K12132 - 2.7.11.1 0.00000000000005247 85.0
TLS2_k127_5652667_2 synthetase, class II (G H P K01892 - 6.1.1.21 0.0000000001709 61.0
TLS2_k127_5676788_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 7.003e-211 662.0
TLS2_k127_5676788_1 Dehydrogenase E1 component K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 479.0
TLS2_k127_5676788_2 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000012 291.0
TLS2_k127_5676788_3 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000003915 205.0
TLS2_k127_5750133_0 heat shock protein 70 K04043,K04044 - - 4.882e-303 940.0
TLS2_k127_5750133_1 Aminotransferase class-III K00823 - 2.6.1.19 1.665e-218 687.0
TLS2_k127_5750133_10 PFAM heat shock protein DnaJ K04082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001065 282.0
TLS2_k127_5750133_11 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001471 250.0
TLS2_k127_5750133_12 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000000000000000000000000000000000001382 200.0
TLS2_k127_5750133_13 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000001256 195.0
TLS2_k127_5750133_14 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000000000000000000000002432 184.0
TLS2_k127_5750133_15 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000244 162.0
TLS2_k127_5750133_16 Belongs to the UPF0102 family K07460 - - 0.000000000000000000000000000000000000002297 154.0
TLS2_k127_5750133_17 FeS assembly protein IscX - - - 0.00000000000000000000000001599 110.0
TLS2_k127_5750133_18 phosphorelay signal transduction system - - - 0.000000000000000000000006566 107.0
TLS2_k127_5750133_19 - - - - 0.0000000002199 63.0
TLS2_k127_5750133_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 1.9e-215 674.0
TLS2_k127_5750133_20 - - - - 0.000000004202 59.0
TLS2_k127_5750133_3 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 615.0
TLS2_k127_5750133_4 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 596.0
TLS2_k127_5750133_5 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 589.0
TLS2_k127_5750133_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 488.0
TLS2_k127_5750133_7 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 434.0
TLS2_k127_5750133_8 DNA replication, synthesis of RNA primer K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004241 381.0
TLS2_k127_5750133_9 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 293.0
TLS2_k127_5750722_0 Urocanase Rossmann-like domain K01712 - 4.2.1.49 0.0 1002.0
TLS2_k127_5750722_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 3.172e-232 726.0
TLS2_k127_5750722_10 - - - - 0.000000000000000000000000000000000000123 152.0
TLS2_k127_5750722_11 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000003617 122.0
TLS2_k127_5750722_12 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.00000000000000000000000009536 121.0
TLS2_k127_5750722_13 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.000000000000000000001648 101.0
TLS2_k127_5750722_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 3.841e-209 661.0
TLS2_k127_5750722_3 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005851 477.0
TLS2_k127_5750722_4 Amidohydrolase family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 472.0
TLS2_k127_5750722_5 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 364.0
TLS2_k127_5750722_6 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 330.0
TLS2_k127_5750722_7 asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 319.0
TLS2_k127_5750722_8 PRMT5 arginine-N-methyltransferase K11434 - 2.1.1.319 0.000000000000000000000000000000000000000000001172 180.0
TLS2_k127_5750722_9 - - - - 0.00000000000000000000000000000000000004709 150.0
TLS2_k127_5799302_0 Tetratricopeptide repeat K08884,K12132 - 2.7.11.1 7.196e-287 910.0
TLS2_k127_5799302_1 Hypusine is a modified amino acid found in eukarya and archaea, but as yet K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 549.0
TLS2_k127_5799302_11 Multicopper oxidase K22348 - 1.16.3.3 0.00000000000000000000000000000002018 134.0
TLS2_k127_5799302_12 PFAM Chorismate mutase, type II - - - 0.0000000000000000000000165 103.0
TLS2_k127_5799302_13 - - - - 0.00000000000000000005206 93.0
TLS2_k127_5799302_14 - - - - 0.000000000000000000138 98.0
TLS2_k127_5799302_2 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 518.0
TLS2_k127_5799302_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 500.0
TLS2_k127_5799302_4 Coenzyme A transferase K01029 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 383.0
TLS2_k127_5799302_5 Coenzyme A transferase K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 363.0
TLS2_k127_5799302_6 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 299.0
TLS2_k127_5799302_7 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009376 280.0
TLS2_k127_5799302_8 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000002455 239.0
TLS2_k127_5799302_9 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000006283 229.0
TLS2_k127_5868676_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 473.0
TLS2_k127_5868676_1 Domain of unknown function (DUF2437) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 357.0
TLS2_k127_5868676_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 300.0
TLS2_k127_5868676_3 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.000000000000000000000000000000000002046 145.0
TLS2_k127_5868676_4 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000002945 62.0
TLS2_k127_5870032_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005427 362.0
TLS2_k127_5870032_1 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001435 274.0
TLS2_k127_5870032_2 TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000003278 250.0
TLS2_k127_5870032_3 creatininase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000003687 222.0
TLS2_k127_5870032_4 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000001409 117.0
TLS2_k127_5870032_5 CarboxypepD_reg-like domain - - - 0.0000924 48.0
TLS2_k127_5928878_0 CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.0 1776.0
TLS2_k127_5928878_1 4 iron, 4 sulfur cluster binding - - - 2.498e-273 852.0
TLS2_k127_5928878_2 4Fe-4S binding domain K00395,K02572,K03616 - 1.8.99.2 0.0000000000000000000000000000000000000000000000000000009072 194.0
TLS2_k127_5928878_3 - - - - 0.000000000000000000000000000000000000000000003276 186.0
TLS2_k127_5928878_5 - - - - 0.0000000000000000000000000000007479 140.0
TLS2_k127_5928878_6 - - - - 0.00000000000000000002278 92.0
TLS2_k127_5937776_0 Heat shock 70 kDa protein K04043 - - 0.0 1034.0
TLS2_k127_5937776_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 7.195e-317 979.0
TLS2_k127_5937776_10 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000294 285.0
TLS2_k127_5937776_11 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001234 272.0
TLS2_k127_5937776_12 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000000001444 266.0
TLS2_k127_5937776_13 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000004192 234.0
TLS2_k127_5937776_14 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000006897 227.0
TLS2_k127_5937776_15 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000007562 228.0
TLS2_k127_5937776_16 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000436 179.0
TLS2_k127_5937776_17 PAP2 superfamily - - - 0.000000000000000000000000000000000000000005813 167.0
TLS2_k127_5937776_18 Phospholipase_D-nuclease N-terminal - - - 0.000000000000000000000000000000006453 134.0
TLS2_k127_5937776_19 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000007038 126.0
TLS2_k127_5937776_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 591.0
TLS2_k127_5937776_20 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000001186 121.0
TLS2_k127_5937776_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 454.0
TLS2_k127_5937776_4 Aminotransferase class-V K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 419.0
TLS2_k127_5937776_5 Two component transcriptional regulator, LytTR family K02477,K07705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 411.0
TLS2_k127_5937776_6 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 413.0
TLS2_k127_5937776_7 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 397.0
TLS2_k127_5937776_8 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 340.0
TLS2_k127_5937776_9 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007291 321.0
TLS2_k127_5937903_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 2.771e-242 759.0
TLS2_k127_5937903_1 phosphorelay signal transduction system K07712,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 409.0
TLS2_k127_5937903_10 Regulatory protein - - - 0.00001617 50.0
TLS2_k127_5937903_11 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000489 46.0
TLS2_k127_5937903_12 Belongs to the TPP enzyme family K01637 - 4.1.3.1 0.00004963 54.0
TLS2_k127_5937903_2 Phosphoesterase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 394.0
TLS2_k127_5937903_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004604 297.0
TLS2_k127_5937903_4 Regulatory protein - - - 0.00000000000000000000000000000000000000000003001 164.0
TLS2_k127_5937903_5 Pfam:DUF59 - - - 0.0000000000000000000000000000004402 124.0
TLS2_k127_5937903_6 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000002663 101.0
TLS2_k127_5937903_7 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.000000000000001256 78.0
TLS2_k127_5937903_8 PFAM blue (type 1) copper domain protein - - - 0.00000000001886 75.0
TLS2_k127_5937903_9 Regulatory protein - - - 0.00000001266 61.0
TLS2_k127_5941265_0 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 529.0
TLS2_k127_5941265_1 Saccharopine dehydrogenase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 423.0
TLS2_k127_5941265_2 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004579 282.0
TLS2_k127_5941265_3 methylamine metabolic process K15977 - - 0.000000000000001269 83.0
TLS2_k127_5941265_4 Dehydrogenase E1 component K11381 - 1.2.4.4 0.00000000000003888 72.0
TLS2_k127_5941265_5 UDP-Gal betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 K00715,K03766 GO:0000139,GO:0001573,GO:0001574,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006688,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008499,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030148,GO:0031090,GO:0031984,GO:0034641,GO:0035250,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0046467,GO:0046513,GO:0048531,GO:0071704,GO:0098588,GO:0098791,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.4.1.206,2.4.1.62 0.0004828 44.0
TLS2_k127_5986478_0 Sodium:solute symporter family - - - 4.339e-215 683.0
TLS2_k127_5986478_1 COG4772 Outer membrane receptor for Fe3 -dicitrate K16091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 606.0
TLS2_k127_5986478_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001738 268.0
TLS2_k127_5986478_11 Ferric uptake regulator family K03711 - - 0.000000000000000000000000000000000000002318 153.0
TLS2_k127_5986478_12 Belongs to the PstS family K02040 - - 0.00000000000000000000538 94.0
TLS2_k127_5986478_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 471.0
TLS2_k127_5986478_3 Protein kinase domain K08884 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 476.0
TLS2_k127_5986478_4 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006831 457.0
TLS2_k127_5986478_5 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 421.0
TLS2_k127_5986478_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007451 400.0
TLS2_k127_5986478_7 Phosphate transport system permease protein PstA K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 388.0
TLS2_k127_5986478_8 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 339.0
TLS2_k127_5986478_9 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 323.0
TLS2_k127_6040751_0 Acyl-CoA dehydrogenase, C-terminal domain K00248,K09478 - 1.3.8.1,1.3.99.12 3.037e-202 642.0
TLS2_k127_6040751_1 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 603.0
TLS2_k127_6040751_10 - - - - 0.000000000000000000000000000000000000000000000000000007559 194.0
TLS2_k127_6040751_11 ARD/ARD' family - - - 0.000000000000000000000000000000000006077 140.0
TLS2_k127_6040751_12 Protein of unknown function (DUF1440) - - - 0.00000000000000000000000000000006802 131.0
TLS2_k127_6040751_13 - - - - 0.00000000000000000000000000001742 124.0
TLS2_k127_6040751_14 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000014 102.0
TLS2_k127_6040751_15 Regulatory protein, FmdB family - - - 0.000000000000005799 78.0
TLS2_k127_6040751_16 - - - - 0.000148 51.0
TLS2_k127_6040751_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 590.0
TLS2_k127_6040751_3 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 389.0
TLS2_k127_6040751_4 Serine aminopeptidase, S33 K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 373.0
TLS2_k127_6040751_5 PFAM zinc iron permease K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 369.0
TLS2_k127_6040751_6 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 358.0
TLS2_k127_6040751_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007128 270.0
TLS2_k127_6040751_9 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002008 236.0
TLS2_k127_6050103_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 394.0
TLS2_k127_6050103_1 Bacterial regulatory protein, Fis family K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 345.0
TLS2_k127_6050103_2 two component, sigma54 specific, transcriptional regulator, Fis family K11384 - - 0.000000003226 62.0
TLS2_k127_6050103_3 PEP-CTERM motif - - - 0.000002754 57.0
TLS2_k127_6090452_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.397e-216 679.0
TLS2_k127_6090452_1 metallocarboxypeptidase activity K14054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 552.0
TLS2_k127_6090452_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009892 519.0
TLS2_k127_6090452_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 501.0
TLS2_k127_6090452_4 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 498.0
TLS2_k127_6090452_5 Enoyl-CoA hydratase/isomerase K01715,K07537 - 4.2.1.100,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009039 387.0
TLS2_k127_6090452_6 Abhydrolase domain containing 18 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 352.0
TLS2_k127_6090452_7 TIGRFAM hopanoid biosynthesis associated glycosyl transferase protein HpnI K00720 - 2.4.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 311.0
TLS2_k127_6090452_8 Ribose/Galactose Isomerase K01808,K01819,K21911 GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701 5.3.1.26,5.3.1.34,5.3.1.6 0.00000000000000000000000000000000000000000000000004887 184.0
TLS2_k127_6090452_9 - - - - 0.00000000000000000000000000000000000000000002158 169.0
TLS2_k127_6111034_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1479.0
TLS2_k127_6111034_1 DNA polymerase X family K02347 - - 1.61e-263 826.0
TLS2_k127_6111034_10 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 570.0
TLS2_k127_6111034_11 Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 563.0
TLS2_k127_6111034_12 PFAM aminotransferase class V K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005116 532.0
TLS2_k127_6111034_13 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 501.0
TLS2_k127_6111034_14 SAICAR synthetase K01923,K13713 - 6.3.2.6,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 434.0
TLS2_k127_6111034_15 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 391.0
TLS2_k127_6111034_16 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007696 399.0
TLS2_k127_6111034_17 transcriptional regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006079 389.0
TLS2_k127_6111034_19 GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007333 356.0
TLS2_k127_6111034_2 PFAM peptidase S9A prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 1.6e-261 824.0
TLS2_k127_6111034_20 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 365.0
TLS2_k127_6111034_21 Belongs to the arginase family K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008785 316.0
TLS2_k127_6111034_22 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 288.0
TLS2_k127_6111034_23 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 291.0
TLS2_k127_6111034_24 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004883 286.0
TLS2_k127_6111034_25 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005126 281.0
TLS2_k127_6111034_26 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K04109,K11178 - 1.17.1.4,1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000007922 258.0
TLS2_k127_6111034_27 - K07283 - - 0.00000000000000000000000000000000000000000000000000000000000000001001 240.0
TLS2_k127_6111034_28 Domain of unknown function (DUF2520) - - - 0.00000000000000000000000000000000000000000000000000000000000008791 233.0
TLS2_k127_6111034_29 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000385 190.0
TLS2_k127_6111034_3 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 4.362e-259 823.0
TLS2_k127_6111034_30 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000004604 177.0
TLS2_k127_6111034_31 PFAM Colicin V production K03558 - - 0.0000000000000000000000000000000000000000000001514 174.0
TLS2_k127_6111034_32 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000007773 177.0
TLS2_k127_6111034_33 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000005275 157.0
TLS2_k127_6111034_34 Glyoxalase-like domain K01759 GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 0.000000000000000000000000000000000000005827 151.0
TLS2_k127_6111034_35 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000007613 145.0
TLS2_k127_6111034_36 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000004559 136.0
TLS2_k127_6111034_37 - - - - 0.00000000000000000000000000000000006123 148.0
TLS2_k127_6111034_38 AI-2E family transporter - - - 0.00000000000000000000000000000000007763 147.0
TLS2_k127_6111034_39 Histidine kinase - - - 0.0000000000000000000000000000000002049 141.0
TLS2_k127_6111034_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K04108 - 1.3.7.9 7.878e-229 736.0
TLS2_k127_6111034_40 - - - - 0.000000000000000000000000000000249 134.0
TLS2_k127_6111034_41 PFAM Lipid A - - - 0.0000000000000000000000000000002828 136.0
TLS2_k127_6111034_43 - - - - 0.000000000000000000000000000001761 127.0
TLS2_k127_6111034_44 Cold shock protein K03704 - - 0.000000000000000000000000000007229 122.0
TLS2_k127_6111034_45 Sortase family K07284 - 3.4.22.70 0.00000000000000000000000000001094 127.0
TLS2_k127_6111034_46 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000000000000000001202 121.0
TLS2_k127_6111034_47 Domain of unknown function (DUF2383) - - - 0.00000000000000000000000000007466 123.0
TLS2_k127_6111034_48 DinB superfamily - - - 0.0000000000000000000000000005849 124.0
TLS2_k127_6111034_49 BON domain K04065 - - 0.0000000000000000000000003947 114.0
TLS2_k127_6111034_5 PFAM Formiminotransferase domain K00603,K13990 - 2.1.2.5,4.3.1.4 8.111e-226 709.0
TLS2_k127_6111034_50 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000009194 106.0
TLS2_k127_6111034_51 Domain of unknown function (DUF4870) - - - 0.000000000000000000000006339 106.0
TLS2_k127_6111034_52 YtxH-like protein - - - 0.0000000000000000000004804 100.0
TLS2_k127_6111034_53 - - - - 0.000000000000000000002683 101.0
TLS2_k127_6111034_54 YjbR - - - 0.00000000000000000001577 105.0
TLS2_k127_6111034_56 - - - - 0.0000000000001063 74.0
TLS2_k127_6111034_58 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000154 49.0
TLS2_k127_6111034_6 PFAM peptidase - - - 3.758e-220 707.0
TLS2_k127_6111034_7 Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 604.0
TLS2_k127_6111034_8 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 590.0
TLS2_k127_6111034_9 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 571.0
TLS2_k127_6137431_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 600.0
TLS2_k127_6137431_1 - - - - 0.0002443 51.0
TLS2_k127_61445_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1439.0
TLS2_k127_61445_1 Phosphate acyltransferases K00655,K01897 - 2.3.1.51,6.2.1.3 0.0 1071.0
TLS2_k127_61445_10 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 326.0
TLS2_k127_61445_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 289.0
TLS2_k127_61445_12 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000003523 272.0
TLS2_k127_61445_13 CYTH K05873 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000895 209.0
TLS2_k127_61445_14 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000000000000000000000000003062 182.0
TLS2_k127_61445_15 cellular response to DNA damage stimulus - GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - 0.00000000000000000000000000000000000000000000755 170.0
TLS2_k127_61445_16 Putative peptidoglycan binding domain - - - 0.0000000000000000000009769 101.0
TLS2_k127_61445_2 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 599.0
TLS2_k127_61445_3 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 578.0
TLS2_k127_61445_4 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007895 480.0
TLS2_k127_61445_5 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 441.0
TLS2_k127_61445_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 443.0
TLS2_k127_61445_7 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 423.0
TLS2_k127_61445_8 Belongs to the 'phage' integrase family. XerC subfamily K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 390.0
TLS2_k127_61445_9 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 343.0
TLS2_k127_6223966_0 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 3.727e-257 812.0
TLS2_k127_6223966_1 Aminotransferase class-V K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 418.0
TLS2_k127_6223966_2 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000001042 139.0
TLS2_k127_6223966_3 Type ii and iii secretion system protein - - - 0.00000000000000001987 94.0
TLS2_k127_6360117_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 507.0
TLS2_k127_6360117_1 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 436.0
TLS2_k127_6360117_2 ABC transporter, substrate-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000005736 163.0
TLS2_k127_6360117_3 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000002931 119.0
TLS2_k127_6360117_4 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000003581 74.0
TLS2_k127_6394052_0 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000001483 252.0
TLS2_k127_6394052_1 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000003733 216.0
TLS2_k127_6394052_2 SMART Tetratricopeptide repeat - - - 0.0000002176 64.0
TLS2_k127_6394052_3 Transcriptional regulatory protein, C terminal K07667 - - 0.0001875 53.0
TLS2_k127_643650_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.599e-236 749.0
TLS2_k127_643650_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 539.0
TLS2_k127_643650_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004907 382.0
TLS2_k127_643650_3 NmrA-like family K19267 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000227 275.0
TLS2_k127_643650_4 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000001832 214.0
TLS2_k127_643650_5 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000002516 177.0
TLS2_k127_643650_6 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000007638 133.0
TLS2_k127_643650_7 Response regulator receiver domain K11443 - - 0.000000000000000000000000000000304 126.0
TLS2_k127_6533229_0 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 1.929e-282 885.0
TLS2_k127_6533229_1 Belongs to the aldehyde dehydrogenase family K00130,K00135,K00146,K22187 - 1.2.1.16,1.2.1.20,1.2.1.39,1.2.1.79,1.2.1.8 8.34e-254 791.0
TLS2_k127_6533229_10 - - - - 0.00000000000000000000000000000000000000000003135 164.0
TLS2_k127_6533229_11 Peptidase family S58 K01266 - 3.4.11.19 0.00000000000000000000000000000000000000002379 155.0
TLS2_k127_6533229_12 S1/P1 Nuclease - - - 0.00000000000000000000000000000000000006655 146.0
TLS2_k127_6533229_13 sh3 domain protein - - - 0.0000000000000000000000000000000000001459 159.0
TLS2_k127_6533229_14 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000001331 107.0
TLS2_k127_6533229_15 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000002736 102.0
TLS2_k127_6533229_16 - - - - 0.00000000000000000000786 102.0
TLS2_k127_6533229_17 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000001849 90.0
TLS2_k127_6533229_2 Tetratricopeptide repeat - - - 4.68e-229 737.0
TLS2_k127_6533229_3 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 420.0
TLS2_k127_6533229_4 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 387.0
TLS2_k127_6533229_5 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 369.0
TLS2_k127_6533229_6 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 362.0
TLS2_k127_6533229_7 Protein of unknown function (DUF418) K07148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 318.0
TLS2_k127_6533229_8 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000344 214.0
TLS2_k127_6533229_9 PFAM thiamine monophosphate synthase K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000001848 192.0
TLS2_k127_6540656_0 cell adhesion involved in biofilm formation K02014,K11031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002351 538.0
TLS2_k127_6540656_1 PFAM Type II secretion system protein E K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 450.0
TLS2_k127_6540656_2 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 372.0
TLS2_k127_6540656_3 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 309.0
TLS2_k127_6540656_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003172 281.0
TLS2_k127_6540656_5 GGDEF domain K13590 - 2.7.7.65 0.000000000000000000000000000000008318 138.0
TLS2_k127_6540656_6 COGs COG3603 conserved K09707 - - 0.00000000000000000000000000003453 121.0
TLS2_k127_6540656_7 histidine kinase A domain protein - - - 0.0000000000000009905 84.0
TLS2_k127_6540656_8 PFAM Peptidoglycan-binding lysin domain - - - 0.0000000009042 70.0
TLS2_k127_6550792_0 Histidine kinase K02482 - 2.7.13.3 6.932e-301 957.0
TLS2_k127_6550792_1 Amidohydrolase family K06015 - 3.5.1.81 6.121e-235 747.0
TLS2_k127_6550792_10 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000002464 136.0
TLS2_k127_6550792_11 helix_turn_helix, Lux Regulon - - - 0.00000000000000000001154 101.0
TLS2_k127_6550792_14 - - - - 0.0000000000002011 83.0
TLS2_k127_6550792_15 Domains in Na-Ca exchangers and integrin-beta4 - - - 0.000000000004189 71.0
TLS2_k127_6550792_2 Bacterial regulatory protein, Fis family - - - 2.65e-199 632.0
TLS2_k127_6550792_3 Aminoacyl-tRNA editing domain K19055 - - 0.00000000000000000000000000000000000000000000000000000009087 199.0
TLS2_k127_6550792_4 Bacterial PH domain K08981 - - 0.000000000000000000000000000000000000000000000000000009142 196.0
TLS2_k127_6550792_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000246 208.0
TLS2_k127_6550792_6 Autotransporter beta-domain - - - 0.00000000000000000000000000000000000000002856 170.0
TLS2_k127_6550792_7 Bacterial PH domain K08981 - - 0.0000000000000000000000000000000000000002256 159.0
TLS2_k127_6550792_8 Response regulator, receiver - - - 0.00000000000000000000000000000000000001839 151.0
TLS2_k127_6550792_9 PhoQ Sensor - - - 0.000000000000000000000000000000009129 137.0
TLS2_k127_657069_0 May be involved in recombinational repair of damaged DNA K03631 - - 7.845e-209 666.0
TLS2_k127_657069_1 WD40-like Beta Propeller K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 589.0
TLS2_k127_657069_10 Oxygen tolerance - - - 0.00004516 48.0
TLS2_k127_657069_2 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 549.0
TLS2_k127_657069_3 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 372.0
TLS2_k127_657069_4 Outer membrane lipoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 293.0
TLS2_k127_657069_5 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003081 280.0
TLS2_k127_657069_6 MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003471 271.0
TLS2_k127_657069_7 TonB C terminal K03832 - - 0.00000000000000000000000000000000000000000000000000001082 203.0
TLS2_k127_657069_8 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000000000000000000000000000000000000000000000003611 191.0
TLS2_k127_6601852_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1176.0
TLS2_k127_6601852_1 Amidohydrolase family - - - 4.755e-317 1003.0
TLS2_k127_6601852_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII - - - 0.00000000000000000000000000000000000006012 154.0
TLS2_k127_6601852_3 PFAM response regulator receiver - - - 0.0000000000000000000000000003089 123.0
TLS2_k127_6601852_4 Protein of unknown function (DUF2934) - - - 0.0000007937 54.0
TLS2_k127_6611319_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0000000000000000000000000000000000000000000000000000000000000000002292 237.0
TLS2_k127_6611319_1 DinB family - - - 0.0000000000000000000000000000000000000000000000000008211 197.0
TLS2_k127_6611319_2 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000269 179.0
TLS2_k127_6611319_3 - - - - 0.0000000000000000000000000000000000000006017 156.0
TLS2_k127_6618054_0 DNA internalization-related competence protein ComEC Rec2 K02238 - - 1.276e-201 658.0
TLS2_k127_6618054_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 556.0
TLS2_k127_6618054_10 outer membrane autotransporter barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001838 248.0
TLS2_k127_6618054_11 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000008279 254.0
TLS2_k127_6618054_12 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000003516 220.0
TLS2_k127_6618054_13 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000005113 209.0
TLS2_k127_6618054_14 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.00000000000000000000000000000000000000000000006447 171.0
TLS2_k127_6618054_15 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000000001878 175.0
TLS2_k127_6618054_16 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000000000000004883 166.0
TLS2_k127_6618054_17 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000002667 157.0
TLS2_k127_6618054_18 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000000000000000366 153.0
TLS2_k127_6618054_19 - - - - 0.000000000000000000000000000000000001162 147.0
TLS2_k127_6618054_2 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 527.0
TLS2_k127_6618054_20 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000000338 143.0
TLS2_k127_6618054_21 Methyltransferase type 11 - - - 0.0000000000000000000000000000005988 132.0
TLS2_k127_6618054_22 - - - - 0.0000000000000000000000000405 112.0
TLS2_k127_6618054_23 - - - - 0.0000000000000000000000004069 119.0
TLS2_k127_6618054_24 - - - - 0.00000000000000000009805 98.0
TLS2_k127_6618054_26 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain - - - 0.00000479 55.0
TLS2_k127_6618054_3 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006688 468.0
TLS2_k127_6618054_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 461.0
TLS2_k127_6618054_5 PFAM Response regulator receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 396.0
TLS2_k127_6618054_6 PFAM glycosyl transferase family 9 K02841 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 323.0
TLS2_k127_6618054_7 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 320.0
TLS2_k127_6618054_8 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 295.0
TLS2_k127_6618054_9 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005225 306.0
TLS2_k127_6634842_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007775 541.0
TLS2_k127_6634842_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 517.0
TLS2_k127_6634842_2 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001837 245.0
TLS2_k127_6648595_0 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 3.683e-229 731.0
TLS2_k127_6648595_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 9.105e-206 651.0
TLS2_k127_6648595_10 penicillin-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 426.0
TLS2_k127_6648595_11 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009395 430.0
TLS2_k127_6648595_12 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 379.0
TLS2_k127_6648595_13 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 372.0
TLS2_k127_6648595_14 Cell division protein FtsQ K03589 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 339.0
TLS2_k127_6648595_15 photosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001315 264.0
TLS2_k127_6648595_16 PAS PAC sensor signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001744 243.0
TLS2_k127_6648595_17 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000000000000000000000000004744 211.0
TLS2_k127_6648595_18 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.000000000000000000000000000000000001661 143.0
TLS2_k127_6648595_19 - - - - 0.00000000000000000000000000001368 128.0
TLS2_k127_6648595_2 Belongs to the MurCDEF family K01924 - 6.3.2.8 6.393e-201 635.0
TLS2_k127_6648595_20 Protein of unknown function, DUF393 - - - 0.0000000007974 59.0
TLS2_k127_6648595_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008036 595.0
TLS2_k127_6648595_4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 586.0
TLS2_k127_6648595_5 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 580.0
TLS2_k127_6648595_6 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 571.0
TLS2_k127_6648595_7 Efflux transporter, RND family, MFP subunit K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 493.0
TLS2_k127_6648595_8 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009199 461.0
TLS2_k127_6648595_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 432.0
TLS2_k127_6691687_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 642.0
TLS2_k127_6691687_1 Asparaginase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 597.0
TLS2_k127_6691687_10 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006587 338.0
TLS2_k127_6691687_11 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006672 292.0
TLS2_k127_6691687_12 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000009693 268.0
TLS2_k127_6691687_13 PFAM peptidase S58 DmpA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001972 256.0
TLS2_k127_6691687_14 Fumarylacetoacetate (FAA) hydrolase family K02554 - 4.2.1.80 0.0000000000000000000000000000000000000000000000000000000000000000005272 249.0
TLS2_k127_6691687_15 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000003114 245.0
TLS2_k127_6691687_16 Transcriptional regulator IclR K13641 - - 0.0000000000000000000000000000000000000000000000000000000000000005618 231.0
TLS2_k127_6691687_17 Cupin 2, conserved barrel domain protein K13640 - - 0.000000000000000000000000000000000000000000000000000000000000002157 226.0
TLS2_k127_6691687_18 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281,K09020 - 3.5.1.110,3.5.1.19 0.00000000000000000000000000000000000000000000000000000000007507 214.0
TLS2_k127_6691687_19 Fumarylacetoacetate (FAA) hydrolase family K01617 - 4.1.1.77 0.00000000000000000000000000000000000000000000003433 190.0
TLS2_k127_6691687_2 Belongs to the aldehyde dehydrogenase family K10217 - 1.2.1.32,1.2.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 567.0
TLS2_k127_6691687_20 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000002789 155.0
TLS2_k127_6691687_21 Isochorismatase family - - - 0.000000000000000000000000000000000002059 145.0
TLS2_k127_6691687_22 Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - - 0.00000000000000000000000004503 111.0
TLS2_k127_6691687_23 Belongs to the 4-oxalocrotonate tautomerase family K01821 - 5.3.2.6 0.000000000008344 67.0
TLS2_k127_6691687_3 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 561.0
TLS2_k127_6691687_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 512.0
TLS2_k127_6691687_5 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 482.0
TLS2_k127_6691687_6 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds K01666 - 4.1.3.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 432.0
TLS2_k127_6691687_7 Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds K04073 - 1.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007592 363.0
TLS2_k127_6691687_8 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 365.0
TLS2_k127_6691687_9 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 358.0
TLS2_k127_6723089_0 Histidine kinase - - - 0.0 1283.0
TLS2_k127_6723089_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1282.0
TLS2_k127_6723089_10 Immunity protein 26 - - - 0.0000000000000000000000000000000000000002667 158.0
TLS2_k127_6723089_11 23S rRNA-intervening sequence protein - - - 0.000000000000000000000000000000004574 133.0
TLS2_k127_6723089_12 lactoylglutathione lyase activity - - - 0.000000000000000000000001125 111.0
TLS2_k127_6723089_13 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000001465 108.0
TLS2_k127_6723089_14 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.00000000000004392 76.0
TLS2_k127_6723089_15 - - - - 0.0000007855 53.0
TLS2_k127_6723089_16 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.000002178 49.0
TLS2_k127_6723089_2 PFAM Glycosyl transferase family 2 - - - 8.466e-256 797.0
TLS2_k127_6723089_3 response regulator, receiver - - - 2.382e-213 671.0
TLS2_k127_6723089_4 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009233 604.0
TLS2_k127_6723089_5 DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 491.0
TLS2_k127_6723089_6 Belongs to the MlaE permease family K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 365.0
TLS2_k127_6723089_7 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 356.0
TLS2_k127_6723089_8 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000159 279.0
TLS2_k127_6723089_9 Domain of unknown function (DUF389) - - - 0.000000000000000000000000000000000000000000000000000007515 211.0
TLS2_k127_672830_0 Amino acid permease - - - 1.919e-284 895.0
TLS2_k127_672830_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 1.919e-270 841.0
TLS2_k127_672830_2 PFAM Cytochrome c-type biogenesis protein CcmB K02194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 304.0
TLS2_k127_672830_3 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000001688 242.0
TLS2_k127_672830_4 PFAM Cytochrome c assembly protein K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000001077 252.0
TLS2_k127_672830_5 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000006018 156.0
TLS2_k127_672830_6 cytochrome - - - 0.00000000000000000000000000000000003341 140.0
TLS2_k127_672830_7 MerR, DNA binding - - - 0.00000000000000000000000000000007279 134.0
TLS2_k127_672830_8 deoxyhypusine monooxygenase activity - - - 0.00000000001324 78.0
TLS2_k127_6757211_0 negative regulation of phosphate transmembrane transport K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000001262 121.0
TLS2_k127_6757211_1 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 K10799 GO:0000209,GO:0000228,GO:0000242,GO:0000723,GO:0000781,GO:0000784,GO:0003674,GO:0003824,GO:0003950,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005694,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0006139,GO:0006259,GO:0006464,GO:0006471,GO:0006725,GO:0006807,GO:0006996,GO:0008104,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009966,GO:0009967,GO:0009987,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010638,GO:0010639,GO:0010646,GO:0010647,GO:0012505,GO:0015630,GO:0016043,GO:0016567,GO:0016740,GO:0016757,GO:0016763,GO:0019219,GO:0019222,GO:0019538,GO:0019899,GO:0023051,GO:0023056,GO:0030111,GO:0030162,GO:0030177,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031331,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032200,GO:0032204,GO:0032205,GO:0032206,GO:0032210,GO:0032212,GO:0032268,GO:0032270,GO:0032446,GO:0032501,GO:0032502,GO:0033036,GO:0033043,GO:0033044,GO:0033365,GO:0034502,GO:0034613,GO:0034641,GO:0035264,GO:0036211,GO:0040007,GO:0040008,GO:0040014,GO:0042176,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043412,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044450,GO:0044454,GO:0044464,GO:0045732,GO:0045862,GO:0045934,GO:0045935,GO:0046483,GO:0048471,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048589,GO:0048638,GO:0050789,GO:0050793,GO:0050794,GO:0051052,GO:0051053,GO:0051054,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051239,GO:0051246,GO:0051247,GO:0051276,GO:0051641,GO:0060249,GO:0060255,GO:0060828,GO:0065007,GO:0065008,GO:0070013,GO:0070198,GO:0070212,GO:0070213,GO:0070647,GO:0070727,GO:0071704,GO:0071840,GO:0080090,GO:0090263,GO:0090304,GO:0090364,GO:0097110,GO:0098687,GO:1901360,GO:1901564,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1904353,GO:1904355,GO:1904356,GO:1904357,GO:1904358,GO:2000058,GO:2000060,GO:2000112,GO:2000278,GO:2000573,GO:2001251,GO:2001252 2.4.2.30 0.00000000000001292 83.0
TLS2_k127_6757211_2 Histidine kinase K07636 - 2.7.13.3 0.0000001536 53.0
TLS2_k127_6767649_0 elongation factor Tu domain 2 protein K02355 - - 4.681e-215 689.0
TLS2_k127_6767649_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 555.0
TLS2_k127_6767649_2 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006402 529.0
TLS2_k127_6767649_3 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009871 352.0
TLS2_k127_6767649_4 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000005207 156.0
TLS2_k127_6767649_5 COG1734 DnaK suppressor protein K06204 - - 0.000000000000000001031 90.0
TLS2_k127_6767649_6 - - - - 0.0000000000000007696 82.0
TLS2_k127_6767649_7 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000546 48.0
TLS2_k127_6799790_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 561.0
TLS2_k127_6799790_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 449.0
TLS2_k127_6799790_10 Belongs to the peptidase S8 family K12287 - - 0.000000000000000001047 103.0
TLS2_k127_6799790_11 - - - - 0.00000000000002041 78.0
TLS2_k127_6799790_12 Parallel beta-helix repeats - - - 0.000000000707 74.0
TLS2_k127_6799790_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008705 440.0
TLS2_k127_6799790_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 443.0
TLS2_k127_6799790_4 Beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005991 480.0
TLS2_k127_6799790_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000000000000000000000000000000499 265.0
TLS2_k127_6799790_6 PFAM thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000001501 230.0
TLS2_k127_6799790_7 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000009271 170.0
TLS2_k127_6799790_8 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000003726 154.0
TLS2_k127_6799790_9 chaperone-mediated protein folding - - - 0.0000000000000000000000000000001232 128.0
TLS2_k127_680315_0 Putative zinc binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 464.0
TLS2_k127_680315_1 C-methyltransferase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 452.0
TLS2_k127_680315_2 FAD dependent oxidoreductase K15736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 444.0
TLS2_k127_680315_3 C-methyltransferase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006116 403.0
TLS2_k127_680315_4 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000183 285.0
TLS2_k127_680315_5 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002467 264.0
TLS2_k127_680315_6 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000006347 203.0
TLS2_k127_680315_7 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000000000001351 179.0
TLS2_k127_680315_8 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000005207 144.0
TLS2_k127_6901665_0 serine-type peptidase activity K01303,K12132 - 2.7.11.1,3.4.19.1 2.877e-282 895.0
TLS2_k127_6901665_1 TonB-dependent receptor - - - 8.336e-231 750.0
TLS2_k127_6901665_2 PFAM Glycosyl transferase, family K00756 - 2.4.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 468.0
TLS2_k127_6901665_3 PFAM Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 445.0
TLS2_k127_6901665_4 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 328.0
TLS2_k127_6901665_5 - - - - 0.0000000000000000000000000000000000000000000000000000000111 209.0
TLS2_k127_6901665_6 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.00000000000000000000000000000000001862 140.0
TLS2_k127_6901665_7 Sodium:sulfate symporter transmembrane region K03319,K14445 - - 0.00000000000008889 72.0
TLS2_k127_6901665_8 mercury ion transmembrane transporter activity K07213,K08364 - - 0.0000002139 57.0
TLS2_k127_6925291_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 8.835e-228 714.0
TLS2_k127_6925291_1 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002535 273.0
TLS2_k127_6925291_3 Thioesterase superfamily - - - 0.0000000000000000000000001814 108.0
TLS2_k127_6954274_0 Asparagine synthase K01953 - 6.3.5.4 2.621e-260 815.0
TLS2_k127_6954274_1 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term K00441 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 357.0
TLS2_k127_6954274_2 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 325.0
TLS2_k127_6954274_3 Glycosyl transferase K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000179 278.0
TLS2_k127_6954274_4 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000149 231.0
TLS2_k127_6998910_0 TIGRFAM Carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 501.0
TLS2_k127_6998910_1 TIGRFAM carbamoyl-phosphate synthase, large subunit K01955 - 6.3.5.5 0.00000004211 54.0
TLS2_k127_7038643_0 CHASE3 domain - - - 1.078e-230 734.0
TLS2_k127_7038643_1 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 604.0
TLS2_k127_7038643_10 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009233 249.0
TLS2_k127_7038643_11 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000001203 211.0
TLS2_k127_7038643_12 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.00000000000000000000000000000000000000000000000000000002588 202.0
TLS2_k127_7038643_13 cog cog1924 - - - 0.00000000000000000000000000000000000000000000000000009812 197.0
TLS2_k127_7038643_14 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.00000000000000000000000000000000000894 138.0
TLS2_k127_7038643_15 Gas vesicle protein K - - - 0.00000000000000000000000000000000003024 147.0
TLS2_k127_7038643_17 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.000000000000000000000000000000006937 130.0
TLS2_k127_7038643_18 response regulator, receiver - - - 0.00000000000000000000000000000001414 132.0
TLS2_k127_7038643_19 peroxiredoxin activity K03386 - 1.11.1.15 0.00000000000000000000000000001315 121.0
TLS2_k127_7038643_2 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003734 536.0
TLS2_k127_7038643_20 belongs to the Fur family K03711,K09825 - - 0.00000000000000000000000000001732 123.0
TLS2_k127_7038643_21 nitric oxide dioxygenase activity - - - 0.00000000000000000000000000002181 121.0
TLS2_k127_7038643_22 O-methyltransferase - - - 0.0000000000000000000000000006298 123.0
TLS2_k127_7038643_23 Response regulator, receiver K10819,K20975 - 2.7.13.3 0.00000000000000000000001795 108.0
TLS2_k127_7038643_24 SnoaL-like domain - - - 0.00000000000000000000004471 105.0
TLS2_k127_7038643_25 Gas vesicle - - - 0.00000000000000000000711 102.0
TLS2_k127_7038643_27 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.00000000000000001964 82.0
TLS2_k127_7038643_28 Transcriptional regulator - - - 0.000000000000002731 81.0
TLS2_k127_7038643_3 amidase activity K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 385.0
TLS2_k127_7038643_31 response regulator receiver - - - 0.00000000009943 68.0
TLS2_k127_7038643_32 Bacterial regulatory proteins, tetR family - - - 0.0000000003701 70.0
TLS2_k127_7038643_33 chaperone-mediated protein complex assembly - - - 0.0000007264 58.0
TLS2_k127_7038643_34 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.000002494 52.0
TLS2_k127_7038643_35 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388,K12527 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9 0.0005208 49.0
TLS2_k127_7038643_4 PAS PAC sensor signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008231 332.0
TLS2_k127_7038643_5 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 302.0
TLS2_k127_7038643_6 benzoyl-CoA reductase K04113 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 304.0
TLS2_k127_7038643_7 Ferritin, Dps family protein K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 294.0
TLS2_k127_7038643_8 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003441 265.0
TLS2_k127_7038643_9 BadF/BadG/BcrA/BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001469 256.0
TLS2_k127_705436_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1155.0
TLS2_k127_705436_1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 466.0
TLS2_k127_705436_2 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 350.0
TLS2_k127_705436_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 299.0
TLS2_k127_705436_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008485 279.0
TLS2_k127_705436_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001788 242.0
TLS2_k127_705436_6 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000000000000000001156 201.0
TLS2_k127_705436_7 amine dehydrogenase activity - - - 0.000000000000000000000000000000000005864 156.0
TLS2_k127_705436_8 GIY-YIG catalytic domain K07461 - - 0.0000000000000000000006469 102.0
TLS2_k127_705436_9 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000004738 89.0
TLS2_k127_7093839_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1108.0
TLS2_k127_7093839_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.475e-255 795.0
TLS2_k127_7093839_10 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006717 413.0
TLS2_k127_7093839_11 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000642 441.0
TLS2_k127_7093839_12 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 408.0
TLS2_k127_7093839_13 Methionine aminopeptidase K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 390.0
TLS2_k127_7093839_14 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 368.0
TLS2_k127_7093839_15 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 388.0
TLS2_k127_7093839_16 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 328.0
TLS2_k127_7093839_17 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 325.0
TLS2_k127_7093839_18 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 297.0
TLS2_k127_7093839_19 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 287.0
TLS2_k127_7093839_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.459e-221 694.0
TLS2_k127_7093839_20 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001046 280.0
TLS2_k127_7093839_21 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001205 267.0
TLS2_k127_7093839_22 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002654 269.0
TLS2_k127_7093839_23 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000000000000000000000000000000000001816 230.0
TLS2_k127_7093839_24 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000002185 232.0
TLS2_k127_7093839_25 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000000008714 223.0
TLS2_k127_7093839_26 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000000009016 218.0
TLS2_k127_7093839_27 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000003019 216.0
TLS2_k127_7093839_28 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000000001745 207.0
TLS2_k127_7093839_29 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000000000001401 211.0
TLS2_k127_7093839_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006674 584.0
TLS2_k127_7093839_30 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000004768 198.0
TLS2_k127_7093839_31 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000000000000002732 197.0
TLS2_k127_7093839_32 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000000000000000000003482 187.0
TLS2_k127_7093839_33 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000001172 175.0
TLS2_k127_7093839_34 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000000000000000000001858 163.0
TLS2_k127_7093839_35 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast K02881 - - 0.000000000000000000000000000000000000000003164 164.0
TLS2_k127_7093839_36 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000003248 156.0
TLS2_k127_7093839_37 - - - - 0.0000000000000000000000000000000000000003776 158.0
TLS2_k127_7093839_38 Protein of unknown function (DUF503) K09764 - - 0.000000000000000000000000000000000000004796 147.0
TLS2_k127_7093839_39 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000000000001646 144.0
TLS2_k127_7093839_4 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000755 580.0
TLS2_k127_7093839_40 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000002069 152.0
TLS2_k127_7093839_41 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000143 143.0
TLS2_k127_7093839_42 - - - - 0.00000000000000000000000000000002054 133.0
TLS2_k127_7093839_43 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000003499 125.0
TLS2_k127_7093839_44 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000000000000000003499 125.0
TLS2_k127_7093839_45 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000000000005272 128.0
TLS2_k127_7093839_46 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000002796 118.0
TLS2_k127_7093839_47 Ribosomal protein L30 K02907 - - 0.0000000000000000000107 94.0
TLS2_k127_7093839_48 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000000007308 77.0
TLS2_k127_7093839_49 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000002646 78.0
TLS2_k127_7093839_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 536.0
TLS2_k127_7093839_50 - - - - 0.000000000008893 74.0
TLS2_k127_7093839_51 DUF167 K09131 - - 0.00000000001685 72.0
TLS2_k127_7093839_52 PFAM VanZ - - - 0.00000001839 62.0
TLS2_k127_7093839_6 Metallopeptidase family M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 531.0
TLS2_k127_7093839_7 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 510.0
TLS2_k127_7093839_8 OPT oligopeptide transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007782 450.0
TLS2_k127_7093839_9 DHH family K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 426.0
TLS2_k127_7269517_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1311.0
TLS2_k127_7269517_1 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 439.0
TLS2_k127_7269517_2 Ankyrin repeat - - - 0.000000000000000000000000007689 124.0
TLS2_k127_729613_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1386.0
TLS2_k127_729613_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.29e-307 951.0
TLS2_k127_729613_10 Cysteine-rich CPXCG - - - 0.000000000000002081 78.0
TLS2_k127_729613_2 Carboxypeptidase regulatory-like domain - - - 9.319e-209 690.0
TLS2_k127_729613_3 TIGRFAM VWFA-related Acidobacterial domain - - - 1.231e-194 629.0
TLS2_k127_729613_4 lipoprotein localization to outer membrane K02004,K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008956 480.0
TLS2_k127_729613_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009932 439.0
TLS2_k127_729613_6 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 316.0
TLS2_k127_729613_7 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 306.0
TLS2_k127_729613_8 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 296.0
TLS2_k127_729613_9 - - - - 0.00000000000000000000000004364 121.0
TLS2_k127_7307733_0 Na+-dependent bicarbonate transporter superfamily K07086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 344.0
TLS2_k127_7307733_1 Beta-lactamase class C and other penicillin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000001094 246.0
TLS2_k127_7307733_2 - - - - 0.0000000000000000000000000000000007966 148.0
TLS2_k127_7364173_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 363.0
TLS2_k127_7364173_1 Mu-like prophage FluMu protein gp28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001869 260.0
TLS2_k127_7364173_2 Phage portal protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004107 250.0
TLS2_k127_7364173_3 Protein of unknown function (DUF3037) - - - 0.000000000000000000000000000000000000000000000000000000000000000005582 234.0
TLS2_k127_7411713_0 glutamine synthetase K01915 GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 1.02e-254 792.0
TLS2_k127_7411713_1 Sodium/hydrogen exchanger family - - - 5.728e-207 662.0
TLS2_k127_7411713_2 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 379.0
TLS2_k127_7411713_3 - - - - 0.00000000000000000000000000000000000000002286 158.0
TLS2_k127_7428001_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 4.56e-288 896.0
TLS2_k127_7428001_1 HD domain - - - 2.236e-239 754.0
TLS2_k127_7428001_10 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 385.0
TLS2_k127_7428001_11 pfam abc K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 376.0
TLS2_k127_7428001_12 Bacterial Peptidase A24 N-terminal domain K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002095 276.0
TLS2_k127_7428001_13 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000001265 235.0
TLS2_k127_7428001_14 3-beta hydroxysteroid dehydrogenase K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000001222 233.0
TLS2_k127_7428001_15 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000006287 225.0
TLS2_k127_7428001_16 BON domain - - - 0.00000000000000000000000000000000000000000000000000000003879 209.0
TLS2_k127_7428001_17 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000001261 192.0
TLS2_k127_7428001_18 - - - - 0.000000000000000000000000000000000000000000000000000531 199.0
TLS2_k127_7428001_19 - - - - 0.0000000000000000000000000000000000000000000000000005834 197.0
TLS2_k127_7428001_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 3.539e-212 670.0
TLS2_k127_7428001_20 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000003814 171.0
TLS2_k127_7428001_21 2'-5' RNA ligase superfamily K01975 - 3.1.4.58 0.00000000000000000000000000000000000000008557 157.0
TLS2_k127_7428001_22 - - - - 0.000000000000000000000000000000000000001022 158.0
TLS2_k127_7428001_23 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000003776 160.0
TLS2_k127_7428001_24 PFAM Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.000000000000000000000000000000000000004694 152.0
TLS2_k127_7428001_25 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000001262 150.0
TLS2_k127_7428001_27 Protein of unknown function (DUF1569) - - - 0.00000000000000000000003387 106.0
TLS2_k127_7428001_28 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000000000000682 96.0
TLS2_k127_7428001_29 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000000000008184 101.0
TLS2_k127_7428001_3 Bacterial regulatory protein, Fis family - - - 8.017e-207 651.0
TLS2_k127_7428001_30 Transcriptional regulator PadR-like family - - - 0.000000000000000005302 87.0
TLS2_k127_7428001_32 deoxyhypusine monooxygenase activity - - - 0.00000000002137 75.0
TLS2_k127_7428001_33 PBS lyase HEAT-like repeat K05384 - - 0.0001124 53.0
TLS2_k127_7428001_4 Belongs to the CinA family K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 521.0
TLS2_k127_7428001_5 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004426 493.0
TLS2_k127_7428001_6 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 494.0
TLS2_k127_7428001_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 438.0
TLS2_k127_7428001_8 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 429.0
TLS2_k127_7428001_9 Histidine kinase K02668,K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005573 400.0
TLS2_k127_7438620_0 Ribosomal protein S1 K02945 - - 2.19e-283 884.0
TLS2_k127_7438620_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 552.0
TLS2_k127_7438620_10 - K05826 - - 0.0000001206 56.0
TLS2_k127_7438620_2 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007954 455.0
TLS2_k127_7438620_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000256 276.0
TLS2_k127_7438620_4 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000000000000000000008576 240.0
TLS2_k127_7438620_5 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity K13991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000001481 167.0
TLS2_k127_7438620_6 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K07443 - - 0.000000000000000000000000000000001253 133.0
TLS2_k127_7438620_8 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000001443 93.0
TLS2_k127_7438620_9 COG1585 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.00000000328 64.0
TLS2_k127_750418_0 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000000000000000000000000000000000000000001805 206.0
TLS2_k127_750418_1 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000436 167.0
TLS2_k127_750418_2 - - - - 0.00000000000323 76.0
TLS2_k127_758554_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 4.557e-313 969.0
TLS2_k127_758554_1 Zinc-binding dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 565.0
TLS2_k127_758554_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 512.0
TLS2_k127_758554_3 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 505.0
TLS2_k127_758554_4 PFAM Alcohol dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 500.0
TLS2_k127_758554_5 TIGRFAM hopanoid-associated sugar epimerase K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000784 456.0
TLS2_k127_758554_6 Squalene/phytoene synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 426.0
TLS2_k127_758554_7 PFAM Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000005085 96.0
TLS2_k127_758554_8 Phosphorylase superfamily K01243 - 3.2.2.9 0.000000204 62.0
TLS2_k127_771255_0 Aldehyde dehydrogenase family K00141,K22187 - 1.2.1.28 6.029e-252 784.0
TLS2_k127_771255_1 Peptidase M16 inactive domain K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008201 529.0
TLS2_k127_771255_2 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 426.0
TLS2_k127_771255_3 PFAM Rieske 2Fe-2S domain protein K00479,K00499 - 1.14.15.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006035 392.0
TLS2_k127_771255_4 SMART PAS domain containing protein - - - 0.0001296 54.0
TLS2_k127_789775_0 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 389.0
TLS2_k127_789775_1 Enoyl-CoA hydratase/isomerase K13766 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 317.0
TLS2_k127_789775_2 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000001065 233.0
TLS2_k127_789775_3 PFAM thioesterase superfamily K07107 - - 0.000000000000000000000000000000000000000000000006881 184.0
TLS2_k127_823154_0 Bacterial protein of unknown function (DUF885) - - - 2.704e-218 694.0
TLS2_k127_823154_1 ArgK protein K07588 - - 0.000000004353 59.0
TLS2_k127_832702_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 7.846e-237 739.0
TLS2_k127_832702_1 Secretin and TonB N terminus short domain K02666 - - 3.361e-225 725.0
TLS2_k127_832702_10 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 439.0
TLS2_k127_832702_11 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 437.0
TLS2_k127_832702_12 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 428.0
TLS2_k127_832702_13 amino acid carrier protein K03310 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 402.0
TLS2_k127_832702_14 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 387.0
TLS2_k127_832702_15 COG0471 Di- and tricarboxylate K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000867 386.0
TLS2_k127_832702_16 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 385.0
TLS2_k127_832702_17 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 357.0
TLS2_k127_832702_18 Cephalosporin hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 312.0
TLS2_k127_832702_19 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000009859 245.0
TLS2_k127_832702_2 Sigma-54 interaction domain - - - 2.221e-222 701.0
TLS2_k127_832702_20 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000009469 219.0
TLS2_k127_832702_21 carbon utilization K02664,K02665,K12280 - - 0.0000000000000000000000000000000000000000000000000000001858 201.0
TLS2_k127_832702_22 DinB superfamily - - - 0.000000000000000000000000000000000000000000000002388 177.0
TLS2_k127_832702_23 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000000001329 175.0
TLS2_k127_832702_24 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000000000000001505 158.0
TLS2_k127_832702_25 PFAM Fimbrial assembly family protein K02663 - - 0.00000000000000000000000000000000000000007001 157.0
TLS2_k127_832702_26 - - - - 0.0000000000000000000000000000000001558 147.0
TLS2_k127_832702_27 Helix-turn-helix domain - - - 0.0000000000000000000000000000000004052 134.0
TLS2_k127_832702_28 PFAM S23 ribosomal protein - - - 0.00000000000000000000000000000005233 130.0
TLS2_k127_832702_3 PAS domain - - - 4.1e-214 682.0
TLS2_k127_832702_30 - - - - 0.00000000002875 71.0
TLS2_k127_832702_31 - - - - 0.000000001495 69.0
TLS2_k127_832702_4 amino acid K03294 - - 3.749e-196 623.0
TLS2_k127_832702_5 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 620.0
TLS2_k127_832702_6 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 537.0
TLS2_k127_832702_7 Type IV pilus assembly protein PilM; K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006581 518.0
TLS2_k127_832702_8 Bacterial regulatory protein, Fis family K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006351 473.0
TLS2_k127_832702_9 Belongs to the Glu Leu Phe Val dehydrogenases family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 447.0
TLS2_k127_872474_0 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 352.0
TLS2_k127_872474_1 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006584 283.0
TLS2_k127_872474_2 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000001045 181.0
TLS2_k127_931245_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 537.0
TLS2_k127_931245_1 Methyltransferase domain - - - 0.00000000000000000001413 101.0
TLS2_k127_9398_0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000001603 231.0
TLS2_k127_9398_1 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000001405 135.0
TLS2_k127_9398_2 - - - - 0.00000000000000001203 90.0
TLS2_k127_9398_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000006405 64.0
TLS2_k127_9398_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000003537 50.0
TLS2_k127_950085_0 Multicopper oxidase K22348 - 1.16.3.3 0.000000000000000000000000000000000000000006778 162.0
TLS2_k127_950085_1 peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000003719 60.0
TLS2_k127_952765_0 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K05559,K05565 GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 6.462e-240 764.0
TLS2_k127_952765_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 5.983e-218 681.0
TLS2_k127_952765_10 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000009293 141.0
TLS2_k127_952765_11 Na+/H+ antiporter subunit K05571 - - 0.0000000000000000000000000000004484 131.0
TLS2_k127_952765_12 PFAM Nickel transport complex, NikM subunit, transmembrane - - - 0.00000000000000000000000000003357 126.0
TLS2_k127_952765_13 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.000000000000000000062 93.0
TLS2_k127_952765_14 Multisubunit Na H antiporter, MnhF subunit K05563,K05570 - - 0.0000000000000000001901 91.0
TLS2_k127_952765_15 negative regulation of phosphate transmembrane transport K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000008694 91.0
TLS2_k127_952765_2 Proton-conducting membrane transporter K05568,K12141 GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 5.38e-202 640.0
TLS2_k127_952765_3 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000977 546.0
TLS2_k127_952765_4 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 484.0
TLS2_k127_952765_5 Transcriptional regulatory protein, C terminal K02483,K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004561 349.0
TLS2_k127_952765_6 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000005168 246.0
TLS2_k127_952765_7 multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000000000000000000000000000000000000000000000316 204.0
TLS2_k127_952765_8 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.000000000000000000000000000000000000005314 148.0
TLS2_k127_952765_9 Na H antiporter, MnhB K05566 - - 0.0000000000000000000000000000000000001889 158.0
TLS2_k127_965056_0 Polyketide synthase modules and related proteins K13613,K13614 - - 1.46e-222 714.0
TLS2_k127_965056_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000002802 172.0
TLS2_k127_965693_0 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 498.0
TLS2_k127_965693_1 Dehydrogenase E1 component K00167,K11381,K21417 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 475.0
TLS2_k127_965693_2 - - - - 0.00000000000000000000000000000007745 126.0
TLS2_k127_965693_3 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K02395 - - 0.000000000000009874 79.0
TLS2_k127_965693_4 Pyridoxamine 5'-phosphate oxidase - - - 0.00000001443 63.0
TLS2_k127_980530_0 Vitamin B12 dependent methionine synthase activation K00548 - 2.1.1.13 0.0 1677.0
TLS2_k127_980530_1 Domain of unknown function (DUF5117) - - - 6.508e-304 953.0
TLS2_k127_980530_10 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000000000009608 191.0
TLS2_k127_980530_11 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000001007 176.0
TLS2_k127_980530_12 - - - - 0.000000000000000000000000000000002147 131.0
TLS2_k127_980530_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000002066 82.0
TLS2_k127_980530_2 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 591.0
TLS2_k127_980530_3 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 534.0
TLS2_k127_980530_4 Belongs to the BshC family K22136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005531 477.0
TLS2_k127_980530_5 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111,K01153 - 1.1.5.3,3.1.21.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009773 386.0
TLS2_k127_980530_6 TIGRFAM MazG family protein K02428,K04765 - 3.6.1.66,3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 361.0
TLS2_k127_980530_7 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006641 351.0
TLS2_k127_980530_8 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 325.0
TLS2_k127_980530_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004659 276.0
TLS2_k127_99504_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 379.0