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Overview

ID MAG04005
Name TLS2_bin.41
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class UBA6911
Order RPQK01
Family RPQK01
Genus
Species
Assembly information
Completeness (%) 76.86
Contamination (%) 3.37
GC content (%) 58.0
N50 (bp) 5,174
Genome size (bp) 4,450,956

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3889

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1000750_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 1.308e-200 639.0
TLS2_k127_1000750_1 PFAM Neutral alkaline nonlysosomal ceramidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 556.0
TLS2_k127_1000750_2 Sugar phosphate permease K02445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 389.0
TLS2_k127_1000750_3 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 377.0
TLS2_k127_1000750_4 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 296.0
TLS2_k127_1000750_5 Linear amide C-N hydrolases, choloylglycine hydrolase family K01442 - 3.5.1.24 0.0000000000000000000000000000000000000000000000002449 190.0
TLS2_k127_1000750_6 Domain of unknown function (DUF1932) K00020 - 1.1.1.31 0.00000000000000000000000000000000001006 147.0
TLS2_k127_1000750_7 - - - - 0.0000000000000000000000009291 112.0
TLS2_k127_1000750_8 SPTR Glycosyl hydrolase, BNR repeat-containing protein - - - 0.0000000001076 73.0
TLS2_k127_1000750_9 YCII-related domain - - - 0.00002057 55.0
TLS2_k127_1006167_0 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 5.098e-274 857.0
TLS2_k127_1006167_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 5.047e-266 825.0
TLS2_k127_1006167_2 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 2.579e-212 662.0
TLS2_k127_1006167_3 MgtC family K07507 - - 0.00000000000000000000000000000000000000000001043 167.0
TLS2_k127_1024709_0 L-fucose isomerase, C-terminal domain - - - 1.35e-206 651.0
TLS2_k127_1024709_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 604.0
TLS2_k127_1024709_2 Protein of unknown function (DUF4038) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 612.0
TLS2_k127_1024709_3 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 416.0
TLS2_k127_1024709_4 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009484 372.0
TLS2_k127_1024709_5 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008731 279.0
TLS2_k127_1024709_6 Periplasmic binding protein LacI transcriptional regulator K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000766 263.0
TLS2_k127_1024709_7 PFAM Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000008397 141.0
TLS2_k127_1024709_8 Tetratricopeptide repeat - - - 0.000025 48.0
TLS2_k127_1036669_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000808 375.0
TLS2_k127_1036669_1 Cytochrome c assembly protein - - - 0.00000000000000000000000000000000000000000000001733 181.0
TLS2_k127_1036669_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000001118 158.0
TLS2_k127_1036669_3 PFAM peptidase - - - 0.0000000000000000002222 90.0
TLS2_k127_1051590_0 Glycosyltransferase like family 2 K07011,K13659 - 2.4.1.264 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001692 293.0
TLS2_k127_1051590_1 Glycosyl transferase family group 2 K07011 - - 0.000000000000000000000000000000000000000000000000000005912 202.0
TLS2_k127_1051590_2 glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000934 149.0
TLS2_k127_1051590_3 methyltransferase - - - 0.00000000000003987 80.0
TLS2_k127_1051590_4 Glycosyltransferase like family 2 K07011 - - 0.000000000003032 71.0
TLS2_k127_105322_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 7.401e-224 703.0
TLS2_k127_105322_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000006083 125.0
TLS2_k127_105322_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000001007 110.0
TLS2_k127_105322_4 ATP synthesis coupled proton transport K02109,K18682 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000366 63.0
TLS2_k127_105322_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00001525 53.0
TLS2_k127_1055192_0 PFAM Phage Tail Collar - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 310.0
TLS2_k127_1055192_1 PFAM Phage Tail Collar - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000031 285.0
TLS2_k127_1055192_2 PFAM Phage Tail Collar - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001266 280.0
TLS2_k127_1055192_3 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000002332 186.0
TLS2_k127_1055192_4 Parallel beta-helix repeats - - - 0.000000000000000000000000000000000000000000000000003349 184.0
TLS2_k127_1065261_0 AcrB/AcrD/AcrF family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 430.0
TLS2_k127_1065261_1 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 313.0
TLS2_k127_1076008_0 negative regulation of phosphate transmembrane transport K01104,K02039,K03741 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 1.20.4.1,3.1.3.48 0.000000000000000000000000000000000000007121 159.0
TLS2_k127_1076008_1 PBP superfamily domain K02040 - - 0.00000000000000000000000000005351 121.0
TLS2_k127_1076008_2 AI-2E family transporter - - - 0.000000000000000000000000001201 125.0
TLS2_k127_1076008_3 - - - - 0.0000002669 60.0
TLS2_k127_1085335_0 ABC transporter K15738 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - 2.29e-279 872.0
TLS2_k127_1085335_1 L-seryl-tRNASec selenium transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 548.0
TLS2_k127_1085335_11 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000001393 70.0
TLS2_k127_1085335_2 Amidohydrolase family K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 492.0
TLS2_k127_1085335_3 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 459.0
TLS2_k127_1085335_4 antibiotic catabolic process K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 411.0
TLS2_k127_1085335_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008671 361.0
TLS2_k127_1085335_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001026 257.0
TLS2_k127_1085335_7 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000003736 240.0
TLS2_k127_1085335_8 ABC transporter related - - - 0.000000000000000000000000000000000000000000000000000008845 195.0
TLS2_k127_1085335_9 PFAM Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000000000009552 192.0
TLS2_k127_1091858_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 590.0
TLS2_k127_1091858_1 7TM-HD extracellular K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 434.0
TLS2_k127_1091858_2 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 355.0
TLS2_k127_1091858_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 350.0
TLS2_k127_1091858_4 PFAM short-chain dehydrogenase reductase SDR K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030497,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002934 273.0
TLS2_k127_1091858_5 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004827 236.0
TLS2_k127_1091858_6 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000006876 108.0
TLS2_k127_1091858_7 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000005633 107.0
TLS2_k127_1091858_8 PilX N-terminal K02673 - - 0.000000001254 68.0
TLS2_k127_1091858_9 Pilus assembly protein PilX - - - 0.0000006035 62.0
TLS2_k127_1101611_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008 522.0
TLS2_k127_1101611_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 360.0
TLS2_k127_1111906_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 421.0
TLS2_k127_1111906_1 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.0000000000003349 79.0
TLS2_k127_1111906_3 PFAM methyltransferase small - - - 0.0001136 53.0
TLS2_k127_1113191_0 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 432.0
TLS2_k127_1113191_1 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.0000000000000000000000000000000000000000000000006832 181.0
TLS2_k127_1113191_2 Glycosyl Hydrolase Family 88 K18581 - 3.2.1.180 0.000000000000000000000000000000000000000000000001069 177.0
TLS2_k127_1124438_0 succinyl-diaminopimelate desuccinylase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 374.0
TLS2_k127_1124438_1 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005373 273.0
TLS2_k127_1127965_0 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 296.0
TLS2_k127_1127965_1 PFAM ROK family protein K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000333 248.0
TLS2_k127_1127965_2 NAD(FAD)-dependent dehydrogenases - - - 0.000000000000000000000000000000001095 132.0
TLS2_k127_1127965_3 PFAM Stress responsive A B Barrel Domain - - - 0.0000000000000000000000000000001188 128.0
TLS2_k127_1127965_4 lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.00005899 51.0
TLS2_k127_1149308_0 type II secretion system protein E K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008175 531.0
TLS2_k127_1149308_1 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000000004481 219.0
TLS2_k127_1149308_2 Flp pilus assembly protein, ATPase CpaE K02282 - - 0.000000000000000000000000000000000001043 153.0
TLS2_k127_1158806_0 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.0000000000000000000000000002185 131.0
TLS2_k127_1158806_1 - - - - 0.00000215 58.0
TLS2_k127_1159575_0 alpha-galactosidase K07407 - 3.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 625.0
TLS2_k127_1159575_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 396.0
TLS2_k127_1159575_2 PIN domain - - - 0.0000000000000000000000000000005068 126.0
TLS2_k127_1159575_3 positive regulation of growth - - - 0.00000000000000002748 88.0
TLS2_k127_1159575_4 membrane - - - 0.00000003508 60.0
TLS2_k127_1159575_5 Resolvase, N terminal domain - - - 0.00000006874 60.0
TLS2_k127_116314_0 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 502.0
TLS2_k127_116314_1 TonB-dependent receptor plug K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005087 280.0
TLS2_k127_116314_2 Xylose isomerase-like TIM barrel K03079 - 5.1.3.22 0.0000000000000000000000000000896 123.0
TLS2_k127_1169207_0 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 355.0
TLS2_k127_1169207_1 competence protein COMEC - - - 0.000002092 49.0
TLS2_k127_1173552_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005129 345.0
TLS2_k127_1173552_1 Xylose isomerase-like TIM barrel K03079 - 5.1.3.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 313.0
TLS2_k127_1173552_2 Histidine biosynthesis bifunctional protein HisIE K11755 GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000000000000000299 226.0
TLS2_k127_1173552_3 pfam abc K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000003783 230.0
TLS2_k127_1173552_4 competence protein COMEC - - - 0.000000000000000000001319 98.0
TLS2_k127_1173552_5 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0008195 42.0
TLS2_k127_1177141_0 TIGRFAM phosphate binding protein K02040 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 400.0
TLS2_k127_1177141_1 Phosphate-selective porin O and P K07221 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005624 267.0
TLS2_k127_1177141_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003623 247.0
TLS2_k127_1184338_0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 492.0
TLS2_k127_1184338_1 COG3250 Beta-galactosidase beta-glucuronidase K01195 - 3.2.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 379.0
TLS2_k127_1184338_2 Aldolase/RraA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004829 352.0
TLS2_k127_1184338_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001116 257.0
TLS2_k127_1184338_4 cAMP biosynthetic process - - - 0.00000000000000000000000000000000000000000001459 179.0
TLS2_k127_1184338_5 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000007611 119.0
TLS2_k127_1184338_6 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.000000389 53.0
TLS2_k127_1202411_0 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006255 428.0
TLS2_k127_1202411_1 Hypothetical glycosyl hydrolase 6 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009456 347.0
TLS2_k127_1202411_2 aspartate--ammonia ligase K01914 - 6.3.1.1 0.0000000000000000000000000000000000000000000000000000000000002781 214.0
TLS2_k127_1214706_0 Erythromycin esterase K06880 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 335.0
TLS2_k127_1214706_1 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 302.0
TLS2_k127_1214706_2 deoxyhypusine monooxygenase activity - - - 0.00000000000000000000000000000000000005897 166.0
TLS2_k127_1215047_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000006232 224.0
TLS2_k127_1215047_1 Fibronectin type III domain protein - - - 0.0000000000000000000000002351 118.0
TLS2_k127_121758_0 ribosylpyrimidine nucleosidase activity K01250 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 396.0
TLS2_k127_121758_1 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000282 251.0
TLS2_k127_121758_2 NIPSNAP - - - 0.0000000000000000000000000000000000000000000001921 171.0
TLS2_k127_121758_3 ACT domain K03469,K09964 - 3.1.26.4 0.0000000000000000000000000000000000579 138.0
TLS2_k127_121758_4 META domain - - - 0.000000000000001917 81.0
TLS2_k127_121758_5 Outer membrane protein (OmpH-like) K06142 - - 0.000002655 57.0
TLS2_k127_1221083_0 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 3.292e-200 640.0
TLS2_k127_1221083_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 529.0
TLS2_k127_1221083_2 COG3119 Arylsulfatase A K01138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 377.0
TLS2_k127_1221083_3 Putative collagen-binding domain of a collagenase - - - 0.0000000000000000000000000000000000000000000000000000142 193.0
TLS2_k127_1221083_4 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000009815 194.0
TLS2_k127_1223127_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 372.0
TLS2_k127_1223127_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000002305 263.0
TLS2_k127_1223127_2 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000007469 204.0
TLS2_k127_1223127_3 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000585 175.0
TLS2_k127_1226925_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1102.0
TLS2_k127_1226925_1 Histidine kinase - - - 0.0000000000000000000000000000000000000546 157.0
TLS2_k127_1226925_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K14161 - - 0.0000000000000000000000000000004466 126.0
TLS2_k127_123986_0 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 416.0
TLS2_k127_123986_1 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000004045 108.0
TLS2_k127_123986_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000069 72.0
TLS2_k127_125616_0 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 514.0
TLS2_k127_125616_1 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007475 431.0
TLS2_k127_125616_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000003585 233.0
TLS2_k127_1264414_0 protein involved in exopolysaccharide biosynthesis - - - 0.00000000003551 77.0
TLS2_k127_1275701_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 370.0
TLS2_k127_1275701_1 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.000000000000000005051 90.0
TLS2_k127_1275701_2 Carboxypeptidase regulatory-like domain - - - 0.000001699 55.0
TLS2_k127_1277666_0 PA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 350.0
TLS2_k127_1277666_1 acyl-coa hydrolase K01073 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 3.1.2.20 0.0000000000000000000000000000000000000000000424 165.0
TLS2_k127_1277666_2 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000001829 125.0
TLS2_k127_128413_0 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 414.0
TLS2_k127_128413_1 PFAM Magnesium chelatase, ChlI subunit K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007161 258.0
TLS2_k127_128413_2 - - - - 0.00003737 50.0
TLS2_k127_1285705_0 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 550.0
TLS2_k127_1285705_1 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 439.0
TLS2_k127_1285705_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004823 249.0
TLS2_k127_1285705_3 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000007179 247.0
TLS2_k127_1285705_4 PFAM ATP-binding region ATPase domain protein K07709 - 2.7.13.3 0.0000000000000000000000000000000002762 151.0
TLS2_k127_1285705_5 Small Multidrug Resistance protein - - - 0.0000000000000000000000000000000003563 140.0
TLS2_k127_1285705_6 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000001293 61.0
TLS2_k127_128751_0 NAD synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 346.0
TLS2_k127_128751_1 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000000009957 170.0
TLS2_k127_1293745_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 1.198e-261 824.0
TLS2_k127_1293745_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 562.0
TLS2_k127_1293745_2 Sodium:solute symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 437.0
TLS2_k127_1293745_3 PFAM molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 371.0
TLS2_k127_1293745_4 2Fe-2S -binding K13483 - - 0.00000000000000000000000000000000000000000000000000000000002247 214.0
TLS2_k127_1293745_5 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000006622 212.0
TLS2_k127_1293745_6 - - - - 0.0000000000000000000000000003266 122.0
TLS2_k127_1293745_7 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000004222 106.0
TLS2_k127_1293745_8 PFAM BadF BadG BcrA BcrD ATPase family K00884,K02616 - 2.7.1.59 0.0000000004549 63.0
TLS2_k127_129529_0 Sodium:neurotransmitter symporter family K03308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 466.0
TLS2_k127_129529_1 PFAM Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 323.0
TLS2_k127_1297789_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 500.0
TLS2_k127_1297789_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005218 377.0
TLS2_k127_1297789_2 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 295.0
TLS2_k127_1297789_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000001769 157.0
TLS2_k127_1297789_4 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000001579 115.0
TLS2_k127_129954_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 334.0
TLS2_k127_129954_1 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000005815 151.0
TLS2_k127_1304221_0 metallocarboxypeptidase activity K14054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 550.0
TLS2_k127_1304221_1 Trypsin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 316.0
TLS2_k127_1310859_0 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 1.428e-239 749.0
TLS2_k127_1310859_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000002635 175.0
TLS2_k127_1310859_2 Nitrogen regulatory protein P-II K04751 - - 0.0000000000000000000000000000000000000000312 162.0
TLS2_k127_1310859_3 - - - - 0.0000000000000004802 90.0
TLS2_k127_1310859_4 Belongs to the glycosyl hydrolase 28 family - - - 0.000001302 55.0
TLS2_k127_1311198_0 Hypothetical glycosyl hydrolase 6 - - - 0.0000000000000000000000000000000000000000000000000000151 199.0
TLS2_k127_1311198_1 - - - - 0.0000000000000000000000000000000000000001485 169.0
TLS2_k127_1320037_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 516.0
TLS2_k127_1320037_1 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 355.0
TLS2_k127_1320037_2 KR domain K10780 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001144 273.0
TLS2_k127_1320037_3 gntR family - - - 0.0000000000000000000002448 106.0
TLS2_k127_1330221_0 exporters of the RND superfamily K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 415.0
TLS2_k127_1330221_1 HNH nucleases - - - 0.000000000000000000000000000000000000000000000004435 177.0
TLS2_k127_134640_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 4.291e-282 878.0
TLS2_k127_134640_1 beta-galactosidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 544.0
TLS2_k127_134640_2 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000005823 98.0
TLS2_k127_1358436_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 304.0
TLS2_k127_1358436_1 TonB-dependent Receptor Plug - - - 0.00009968 53.0
TLS2_k127_137268_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 420.0
TLS2_k127_137268_1 Belongs to the TrpC family K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.000000000000000000000000000000000000000000000004759 182.0
TLS2_k127_137268_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000002209 127.0
TLS2_k127_137268_3 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000006683 83.0
TLS2_k127_1394567_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 433.0
TLS2_k127_1394567_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 409.0
TLS2_k127_1394567_2 Preprotein translocase, YajC K03210 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000003473 93.0
TLS2_k127_1394567_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000678 70.0
TLS2_k127_1396232_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1326.0
TLS2_k127_1396232_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 3.993e-275 854.0
TLS2_k127_1396232_10 - - - - 0.000000000000000000606 90.0
TLS2_k127_1396232_11 selT selW selH selenoprotein K07401 - - 0.0000000000007676 70.0
TLS2_k127_1396232_2 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 406.0
TLS2_k127_1396232_3 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 349.0
TLS2_k127_1396232_4 GTPase activity K03596 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 306.0
TLS2_k127_1396232_5 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008968 287.0
TLS2_k127_1396232_6 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000005184 201.0
TLS2_k127_1396232_7 PFAM regulatory protein ArsR - - - 0.000000000000000000000000000000000999 133.0
TLS2_k127_1396232_8 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 GO:0005575,GO:0005576 - 0.00000000000000000000003807 105.0
TLS2_k127_1396232_9 Protein of unknown function (DUF2892) - - - 0.00000000000000000000971 95.0
TLS2_k127_1412927_0 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 314.0
TLS2_k127_1412927_1 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009008 309.0
TLS2_k127_1412927_2 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000287 236.0
TLS2_k127_1412927_3 O-acyltransferase activity K00661,K03818 - 2.3.1.79 0.0000000000000000000000000000000000000000000000000000000000000003733 226.0
TLS2_k127_1412927_4 - - - - 0.00000000000000000000000000000001815 142.0
TLS2_k127_1431555_0 pilus organization - - - 0.00000000000000000000378 108.0
TLS2_k127_1431555_1 Protein involved in outer membrane biogenesis - - - 0.00000000000000000002916 96.0
TLS2_k127_1431555_2 domain protein K01179,K01342,K01406,K07004,K12287,K14194,K15125,K20276 - 3.2.1.4,3.4.21.62,3.4.24.40 0.000000001251 68.0
TLS2_k127_1431555_3 Belongs to the 'phage' integrase family K04763 - - 0.0008582 48.0
TLS2_k127_1433070_0 Heparinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007251 537.0
TLS2_k127_1433070_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.000000000000000000000000000000000000000002274 158.0
TLS2_k127_1447681_0 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 371.0
TLS2_k127_1447681_1 PFAM GHMP kinase K07031 - 2.7.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 332.0
TLS2_k127_1447681_2 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000000000000000000000002358 145.0
TLS2_k127_1447681_3 Polysaccharide biosynthesis/export protein - - - 0.00000000000000003318 92.0
TLS2_k127_145005_0 PQQ enzyme repeat K00117 - 1.1.5.2 1.114e-279 876.0
TLS2_k127_145005_1 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000001129 148.0
TLS2_k127_1463975_0 Bacterial extracellular solute-binding protein K02048 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 399.0
TLS2_k127_1463975_1 ATPase activity K02045 - 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 307.0
TLS2_k127_1463975_2 ATPase-coupled sulfate transmembrane transporter activity K02018,K02046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001468 272.0
TLS2_k127_1463975_3 ATPase-coupled sulfate transmembrane transporter activity K02046,K02047 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003658 271.0
TLS2_k127_1463975_4 TOBE domain K02052 - - 0.00000000000000000000000000000000000000000000000000000164 202.0
TLS2_k127_1463975_5 Transcriptional regulator - - - 0.00000000000000000000000000000004325 130.0
TLS2_k127_1486582_0 Radical SAM - - - 1.179e-276 865.0
TLS2_k127_1486582_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000939 231.0
TLS2_k127_1486582_2 iron-sulfur cluster assembly K07400,K13628 - - 0.00000000000000000000000000000000000000000001307 169.0
TLS2_k127_1486582_3 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000000001486 152.0
TLS2_k127_1486582_4 Transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000000000008749 147.0
TLS2_k127_1486582_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000005997 148.0
TLS2_k127_1486582_6 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000006406 124.0
TLS2_k127_1486582_7 - - - - 0.0000000006073 68.0
TLS2_k127_1486582_8 Bacterial periplasmic substrate-binding proteins K02030 - - 0.00000000139 70.0
TLS2_k127_1486582_9 AntiSigma factor K03088 - - 0.00001725 53.0
TLS2_k127_149005_0 4Fe-4S dicluster domain K00184 - - 0.0 1147.0
TLS2_k127_149005_1 Polysulphide reductase, NrfD K00185 - - 3.678e-216 679.0
TLS2_k127_149005_10 Tetratricopeptide repeat - - - 0.0001342 53.0
TLS2_k127_149005_2 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 392.0
TLS2_k127_149005_3 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 291.0
TLS2_k127_149005_4 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001611 239.0
TLS2_k127_149005_5 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000007742 234.0
TLS2_k127_149005_6 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000006294 221.0
TLS2_k127_149005_7 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000002023 123.0
TLS2_k127_149005_8 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000008517 81.0
TLS2_k127_1494106_0 Domain of Unknown function (DUF542) K07322 - - 0.000000000000000000000000000000000000000000000000000000003802 207.0
TLS2_k127_1494106_1 domain, Protein - - - 0.000000000000000000000000000005742 128.0
TLS2_k127_1494106_2 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00055 46.0
TLS2_k127_1498976_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 9.967e-202 642.0
TLS2_k127_1498976_1 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000001046 165.0
TLS2_k127_1498976_2 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000000007212 132.0
TLS2_k127_1498976_3 PFAM Peptidase M23 - - - 0.0000000000000004046 78.0
TLS2_k127_1498976_4 Protein of unknown function (DUF1189) - - - 0.000000001766 68.0
TLS2_k127_1501593_0 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000151 222.0
TLS2_k127_1501593_1 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000008841 147.0
TLS2_k127_1501593_2 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000001631 79.0
TLS2_k127_1501593_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000009289 61.0
TLS2_k127_1505339_0 PFAM Uncharacterised BCR, COG1649 K01186,K01197,K05988,K11931,K18197 - 3.2.1.11,3.2.1.18,3.2.1.35,4.2.2.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 385.0
TLS2_k127_1505339_1 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 333.0
TLS2_k127_1505339_2 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000007116 186.0
TLS2_k127_151296_0 DeoC/LacD family aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 306.0
TLS2_k127_151296_1 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004142 226.0
TLS2_k127_151296_2 helix_turn _helix lactose operon repressor K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000005461 233.0
TLS2_k127_151296_3 Methanol-cobalamin methyltransferase B subunit K04480 - 2.1.1.90 0.00000000000000000000000000001342 123.0
TLS2_k127_151296_4 Calcineurin-like phosphoesterase - - - 0.000000000000000000007356 107.0
TLS2_k127_151296_5 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000001339 92.0
TLS2_k127_1514282_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 304.0
TLS2_k127_1514282_1 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000000000005698 175.0
TLS2_k127_1514282_2 - - - - 0.000000000000000000000000000000000001161 144.0
TLS2_k127_1514282_3 Glyoxalase-like domain - - - 0.0000000000000000000000000002249 116.0
TLS2_k127_1514282_4 - - - - 0.000000000000000000000005772 108.0
TLS2_k127_1514282_5 Involved in the tonB-independent uptake of proteins - - - 0.00000000000001621 87.0
TLS2_k127_1517222_0 Cellulase (glycosyl hydrolase family 5) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 407.0
TLS2_k127_1517222_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000002217 256.0
TLS2_k127_1517222_2 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000001778 143.0
TLS2_k127_1519958_0 beta-fructofuranosidase activity - - - 0.0000000000000000000000008519 120.0
TLS2_k127_1519958_1 xyloglucan:xyloglucosyl transferase activity - - - 0.00000000000001559 88.0
TLS2_k127_1519958_2 Glycosyl hydrolase family 67 N-terminus - - - 0.000000000008533 79.0
TLS2_k127_1519958_3 GDSL-like Lipase/Acylhydrolase - - - 0.0000000299 62.0
TLS2_k127_1520332_0 alpha beta - - - 5.506e-228 728.0
TLS2_k127_1520332_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01683,K01684 - 4.2.1.5,4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 304.0
TLS2_k127_1520332_2 PFAM N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) K01787 - 5.1.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000002818 276.0
TLS2_k127_1520332_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000008297 204.0
TLS2_k127_1520332_4 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.0000000000000000000000000000000000000000000000003821 187.0
TLS2_k127_1520332_5 Oxidoreductase - - - 0.00000006833 64.0
TLS2_k127_1520332_6 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 0.00001638 55.0
TLS2_k127_1521380_0 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 438.0
TLS2_k127_1521380_1 PFAM short chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 415.0
TLS2_k127_1521380_2 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 417.0
TLS2_k127_1521380_3 Belongs to the UPF0337 (CsbD) family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000005131 94.0
TLS2_k127_1532_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 340.0
TLS2_k127_1532_1 - - - - 0.0000000000000000000000000000000000000003362 172.0
TLS2_k127_1532_2 FG-GAP repeat protein - - - 0.00000000000000000006159 106.0
TLS2_k127_1532_3 PFAM von Willebrand factor type A - - - 0.000000001783 68.0
TLS2_k127_1535758_0 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 314.0
TLS2_k127_1535758_1 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001094 252.0
TLS2_k127_1535758_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K07566 - 2.7.7.87 0.00000000000000000000000000000000000007304 151.0
TLS2_k127_1535758_3 Endopeptidase La - - - 0.00000000000000000000000001731 111.0
TLS2_k127_1535758_4 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000005327 86.0
TLS2_k127_1548725_0 Family of unknown function (DUF5458) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003632 245.0
TLS2_k127_1548725_1 - - - - 0.000000000000000000000000000000000000000000002593 168.0
TLS2_k127_1548725_2 - - - - 0.00000000000000000000000000000000000007733 147.0
TLS2_k127_1548725_3 Family of unknown function (DUF5458) - - - 0.0000000000000000000000000000000000003327 149.0
TLS2_k127_1548725_4 Family of unknown function (DUF5458) - - - 0.0000000000000000000000000000001377 130.0
TLS2_k127_155432_0 Bacterial alpha-L-rhamnosidase C-terminal domain - - - 1.17e-303 949.0
TLS2_k127_155432_1 Histidine kinase K07675 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000001573 201.0
TLS2_k127_1557494_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 526.0
TLS2_k127_1557494_1 PFAM GTP-binding signal recognition particle SRP54 G- domain K02404 - - 0.000000000000000000000000000000000000000268 159.0
TLS2_k127_1575172_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 3.834e-321 1014.0
TLS2_k127_1575172_1 Di-glucose binding within endoplasmic reticulum - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 386.0
TLS2_k127_1575172_2 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000004588 168.0
TLS2_k127_1576309_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004279 332.0
TLS2_k127_1576309_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 336.0
TLS2_k127_1576309_2 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 304.0
TLS2_k127_1576309_3 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005861 269.0
TLS2_k127_1576309_4 TIGRFAM efflux transporter, RND family, MFP subunit K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000001 248.0
TLS2_k127_1576309_5 Uncharacterized protein conserved in bacteria (DUF2059) K09924 - - 0.000000000000000003661 92.0
TLS2_k127_1585923_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 466.0
TLS2_k127_1588079_0 L-lactate permease K03303 - - 4.65e-225 721.0
TLS2_k127_1588079_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 306.0
TLS2_k127_1588079_2 PFAM ADP-ribosylation Crystallin J1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 295.0
TLS2_k127_1588079_3 response regulator - - - 0.00000000000000000000001233 107.0
TLS2_k127_1588079_4 polysaccharide biosynthetic process K16712 - - 0.00000000000000000000454 100.0
TLS2_k127_1601739_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 4.868e-226 713.0
TLS2_k127_1601739_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006586 564.0
TLS2_k127_1601739_2 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006943 278.0
TLS2_k127_1601739_3 Ribose/Galactose Isomerase K01808,K01819,K21911 GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701 5.3.1.26,5.3.1.34,5.3.1.6 0.0000000000000000000000000000000000000000000002747 171.0
TLS2_k127_1601739_4 HELICc2 K03722 - 3.6.4.12 0.000000000000000000000000000000009727 132.0
TLS2_k127_160847_0 Domain of unknown function (DUF5060) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 530.0
TLS2_k127_160847_1 Dynamin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 503.0
TLS2_k127_160847_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006542 437.0
TLS2_k127_160847_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 388.0
TLS2_k127_160847_4 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 383.0
TLS2_k127_160847_5 PFAM Transaldolase K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005528 331.0
TLS2_k127_160847_6 amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000001633 184.0
TLS2_k127_161036_0 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 456.0
TLS2_k127_161036_1 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 384.0
TLS2_k127_161036_2 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 339.0
TLS2_k127_161036_3 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 312.0
TLS2_k127_161036_4 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 288.0
TLS2_k127_161036_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000001276 239.0
TLS2_k127_161036_6 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000008766 181.0
TLS2_k127_1616532_0 3-demethylubiquinone-9 3-O-methyltransferase activity K07011,K20444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007997 347.0
TLS2_k127_1616532_1 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003612 262.0
TLS2_k127_1624565_0 NHLM bacteriocin system ABC transporter, peptidase ATP-binding protein - - - 7.453e-258 814.0
TLS2_k127_1624565_1 NHLM bacteriocin system ABC transporter, ATP-binding protein K06148 - - 1.074e-220 717.0
TLS2_k127_1624565_2 Radical SAM K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 378.0
TLS2_k127_1624565_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 356.0
TLS2_k127_1624565_4 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000000000001114 220.0
TLS2_k127_1624565_7 Acetyltransferase (GNAT) family - - - 0.00004647 53.0
TLS2_k127_1631944_0 glucosamine-6-phosphate deaminase activity K01057,K02564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.1.1.31,3.5.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007503 409.0
TLS2_k127_1631944_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 306.0
TLS2_k127_1631944_2 xylulose kinase K00854 - 2.7.1.17 0.00000000000000000000000000000192 133.0
TLS2_k127_1646867_0 GTP-binding protein TypA K06207 - - 1.22e-254 797.0
TLS2_k127_1646867_1 Radical SAM domain protein K15045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008375 424.0
TLS2_k127_1646867_2 Alginate export K16081 - - 0.00000000000000000000000000001453 128.0
TLS2_k127_1651123_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1396.0
TLS2_k127_1651123_1 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 466.0
TLS2_k127_1651123_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006084 277.0
TLS2_k127_1655072_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000007258 221.0
TLS2_k127_1655072_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000006042 167.0
TLS2_k127_1667165_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 K00341 - 1.6.5.3 1.58e-201 646.0
TLS2_k127_1667165_1 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005233 539.0
TLS2_k127_1667165_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 397.0
TLS2_k127_1667165_3 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 295.0
TLS2_k127_1667165_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000001255 166.0
TLS2_k127_1679064_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 351.0
TLS2_k127_1679064_1 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004183 273.0
TLS2_k127_1679064_2 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000001704 169.0
TLS2_k127_1681030_0 short-chain dehydrogenase reductase SDR K12454 - 5.1.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009219 382.0
TLS2_k127_1681030_1 carbamoyl transferase, NodU family K00612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 317.0
TLS2_k127_1681030_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007134 286.0
TLS2_k127_1687409_0 Neutral/alkaline non-lysosomal ceramidase, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 537.0
TLS2_k127_1687409_1 Glucosamine-6-phosphate isomerase K02564 - 3.5.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009223 494.0
TLS2_k127_1687409_2 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000004561 58.0
TLS2_k127_1689845_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00066 - 1.1.1.132 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 485.0
TLS2_k127_1689845_1 PFAM Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 444.0
TLS2_k127_1689845_2 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000001112 152.0
TLS2_k127_1703472_0 WD40-like Beta Propeller Repeat - - - 1.728e-234 760.0
TLS2_k127_1703472_1 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001189 287.0
TLS2_k127_1703472_2 PRC-barrel domain - - - 0.0000000000000000000000000000000000000000000000000000004012 203.0
TLS2_k127_1703472_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000273 164.0
TLS2_k127_1710257_0 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 516.0
TLS2_k127_1710257_1 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 297.0
TLS2_k127_1726790_0 ABC 3 transport family K11709 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 419.0
TLS2_k127_1726790_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 403.0
TLS2_k127_1726790_2 Belongs to the bacterial solute-binding protein 9 family K09818,K11707 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008579 386.0
TLS2_k127_1726790_3 ABC 3 transport family K11708 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 371.0
TLS2_k127_1726790_4 ATPases associated with a variety of cellular activities K09817,K11710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 358.0
TLS2_k127_1726790_5 Aminotransferase K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000001476 231.0
TLS2_k127_1726790_6 FeoA K03709 - - 0.000000000000000000000000000000000000000000000000000000000000001247 227.0
TLS2_k127_1726790_7 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000005106 166.0
TLS2_k127_1740851_0 RNA secondary structure unwinding K03724 - - 7.139e-203 653.0
TLS2_k127_174255_0 Tetratricopeptide repeat - - - 3.823e-299 927.0
TLS2_k127_174255_1 OmpA family - - - 1.168e-242 753.0
TLS2_k127_174255_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 559.0
TLS2_k127_174255_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001378 250.0
TLS2_k127_174480_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 7.618e-206 648.0
TLS2_k127_174480_1 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 495.0
TLS2_k127_174480_2 Aminotransferase K11358 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000002085 207.0
TLS2_k127_174480_3 PFAM Amino acid-binding ACT - - - 0.0000000000000000000000000000000000000000000001917 171.0
TLS2_k127_174480_4 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family K16048 - - 0.00000000000000000000000000000001508 132.0
TLS2_k127_1746268_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1504.0
TLS2_k127_1757948_0 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007222 365.0
TLS2_k127_1757948_1 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004898 278.0
TLS2_k127_1757948_2 Domain of Unknown Function (DUF1206) - - - 0.000000000000000000000000000000000000000000000000000000000000000001027 239.0
TLS2_k127_1757948_3 protein kinase related protein - - - 0.000000000000000000000000000000000000000000002095 189.0
TLS2_k127_1757948_4 BON domain - - - 0.00000000000000000000000000000000000000000009167 165.0
TLS2_k127_1757948_5 Glycosyl hydrolase-like 10 - - - 0.000000000000000000000000000000000000000008316 169.0
TLS2_k127_1757948_6 Membrane - - - 0.00002005 54.0
TLS2_k127_1762325_0 lyase activity - - - 4.463e-285 891.0
TLS2_k127_1762325_1 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 374.0
TLS2_k127_1762325_2 RNA pseudouridylate synthase K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009477 297.0
TLS2_k127_1762325_3 Carbohydrate-binding family 9 - - - 0.00001405 48.0
TLS2_k127_1779786_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000594 291.0
TLS2_k127_1779786_1 Hydrogenase accessory protein HypB K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000002761 233.0
TLS2_k127_1779786_2 Belongs to the complex I 20 kDa subunit family - - - 0.00000000000000006323 81.0
TLS2_k127_1779786_3 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000047 50.0
TLS2_k127_1796364_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 0.0 1031.0
TLS2_k127_1796364_1 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002067 282.0
TLS2_k127_1805611_0 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009453 250.0
TLS2_k127_1805611_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000922 234.0
TLS2_k127_1805611_2 arylsulfatase activity K01138 - - 0.00000000000000000000000000000000000000000001033 168.0
TLS2_k127_1805611_3 Inosine-uridine preferring nucleoside hydrolase - - - 0.0000000000000000000000000002468 128.0
TLS2_k127_1806357_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 516.0
TLS2_k127_1806357_1 Thioredoxin-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000559 417.0
TLS2_k127_1806357_2 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000008182 191.0
TLS2_k127_1806357_3 - - - - 0.0000007992 60.0
TLS2_k127_1810844_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 455.0
TLS2_k127_1810844_1 PFAM NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 394.0
TLS2_k127_1810844_2 Belongs to the DapB family K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000001232 214.0
TLS2_k127_1810844_3 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000008473 143.0
TLS2_k127_1827423_0 FecR protein - - - 0.00000000000000000000000000000000000000000000000001422 195.0
TLS2_k127_1827423_1 belongs to the sigma-70 factor family, ECF subfamily - - - 0.0000000000000004936 87.0
TLS2_k127_1827423_2 Domain of Unknown Function (DUF748) - - - 0.000003248 56.0
TLS2_k127_1834324_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009921 604.0
TLS2_k127_1834324_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 490.0
TLS2_k127_1834324_2 Aminomethyltransferase folate-binding domain K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 377.0
TLS2_k127_1834324_3 Signal transducing histidine kinase, homodimeric K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 307.0
TLS2_k127_1834324_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000002937 162.0
TLS2_k127_1855096_0 Belongs to the glycosyl hydrolase 28 family - - - 0.000000000000000000000000000000000000000000000000000000001785 227.0
TLS2_k127_1855096_2 Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine K20333 - - 0.00000000000000000009058 105.0
TLS2_k127_1855096_3 PFAM glycoside hydrolase, family 9 K01179 - 3.2.1.4 0.00000009579 63.0
TLS2_k127_1857533_0 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001339 261.0
TLS2_k127_1865371_0 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 6.906e-205 650.0
TLS2_k127_1865371_1 TIGRFAM galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 495.0
TLS2_k127_1865371_2 phosphorelay sensor kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 315.0
TLS2_k127_1883972_0 carbohydrate kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006239 330.0
TLS2_k127_1883972_1 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 335.0
TLS2_k127_1891944_0 Putative glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 339.0
TLS2_k127_1891944_1 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000003101 238.0
TLS2_k127_1898886_0 epimerase K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 293.0
TLS2_k127_1898886_1 3-beta hydroxysteroid dehydrogenase/isomerase family K10011,K12449 - 1.1.1.305,2.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000003583 250.0
TLS2_k127_1898886_2 lipolytic protein G-D-S-L family - - - 0.0000000000000001099 92.0
TLS2_k127_1900789_0 PFAM sigma-54 factor interaction domain-containing protein K02481,K07714,K10943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 411.0
TLS2_k127_1900789_1 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000002482 216.0
TLS2_k127_1900789_2 - K01992,K16919 - - 0.0000000000000000000000000000000000000000000001233 187.0
TLS2_k127_1900789_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000002867 164.0
TLS2_k127_1900789_4 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.00000004914 65.0
TLS2_k127_1908468_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 372.0
TLS2_k127_1908468_1 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 343.0
TLS2_k127_1908468_2 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005554 256.0
TLS2_k127_1910173_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 297.0
TLS2_k127_1915191_0 permease - - - 0.0000000000000000000000000000000000000000000000001339 192.0
TLS2_k127_1915191_1 PFAM methyltransferase - - - 0.00000000000000000000000000000007296 139.0
TLS2_k127_1915191_2 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000004237 90.0
TLS2_k127_1918461_0 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 610.0
TLS2_k127_1918461_1 COG3119 Arylsulfatase A K01138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 462.0
TLS2_k127_1918461_2 Polysaccharide pyruvyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004917 453.0
TLS2_k127_1918461_3 geranylgeranyl reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 331.0
TLS2_k127_1918461_4 Protein of unknown function (DUF2914) - - - 0.0000000000000001729 91.0
TLS2_k127_1918461_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000003944 76.0
TLS2_k127_1918461_6 TrkA-C domain protein K07228 - - 0.000004807 51.0
TLS2_k127_1929208_0 PFAM glycoside hydrolase, family 29 K01206 - 3.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 470.0
TLS2_k127_1929208_1 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 358.0
TLS2_k127_1929208_2 Belongs to the glycosyl hydrolase 31 family K01811 - 3.2.1.177 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007522 313.0
TLS2_k127_1929208_3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 323.0
TLS2_k127_1929208_4 helix_turn _helix lactose operon repressor K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003374 251.0
TLS2_k127_1929208_5 addiction module antidote protein, CC2985 family - - - 0.00000000000000000000000000000000000000000000000000000001674 217.0
TLS2_k127_1941512_0 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 361.0
TLS2_k127_1941512_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 355.0
TLS2_k127_1941512_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000002522 238.0
TLS2_k127_1941512_3 inorganic diphosphatase activity K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000003274 196.0
TLS2_k127_1941512_4 Domain of unknown function (DUF4112) - - - 0.0000000000000000000000000001369 121.0
TLS2_k127_1945871_0 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 609.0
TLS2_k127_1945871_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000413 580.0
TLS2_k127_1945871_10 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000001601 203.0
TLS2_k127_1945871_11 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000001106 194.0
TLS2_k127_1945871_12 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000000484 195.0
TLS2_k127_1945871_13 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000001236 159.0
TLS2_k127_1945871_14 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000005923 154.0
TLS2_k127_1945871_15 binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000008841 147.0
TLS2_k127_1945871_16 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000001906 110.0
TLS2_k127_1945871_17 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000003278 104.0
TLS2_k127_1945871_18 G5 domain protein - - - 0.00000000000001763 79.0
TLS2_k127_1945871_19 - - - - 0.000000002031 67.0
TLS2_k127_1945871_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 467.0
TLS2_k127_1945871_20 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions - GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564 - 0.0000003407 59.0
TLS2_k127_1945871_3 Replicative DNA helicase K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007532 461.0
TLS2_k127_1945871_4 Large family of predicted nucleotide-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 413.0
TLS2_k127_1945871_5 involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 333.0
TLS2_k127_1945871_6 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000005274 275.0
TLS2_k127_1945871_7 Inositol monophosphatase K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000006858 263.0
TLS2_k127_1945871_8 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K00966,K16881 - 2.7.7.13,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000005713 253.0
TLS2_k127_1945871_9 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000003302 244.0
TLS2_k127_1946276_0 Belongs to the peptidase M16 family - - - 0.00000002577 66.0
TLS2_k127_1960725_0 polyphosphate kinase activity - - - 6.296e-197 625.0
TLS2_k127_1960725_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 346.0
TLS2_k127_1960725_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000161 263.0
TLS2_k127_1968359_0 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 466.0
TLS2_k127_1968359_1 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005103 315.0
TLS2_k127_1968359_2 Haem-binding domain - - - 0.0000000000000000000000000008753 119.0
TLS2_k127_1968359_3 Protein SSUH2 homolog - - - 0.00008782 48.0
TLS2_k127_1974154_0 PFAM Hemerythrin HHE cation binding domain K09155 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 447.0
TLS2_k127_1974154_1 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 395.0
TLS2_k127_1974154_10 Dihydroneopterin aldolase - - - 0.000000000001884 72.0
TLS2_k127_1974154_2 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 284.0
TLS2_k127_1974154_3 Rhomboid family - - - 0.000000000000000000000000000000000000000000000005428 182.0
TLS2_k127_1974154_4 Uncharacterized conserved protein (DUF2249) - - - 0.000000000000000000000000000000000000000001545 162.0
TLS2_k127_1974154_5 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.00000000000000000000000000000000004306 143.0
TLS2_k127_1974154_6 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000001192 133.0
TLS2_k127_1974154_7 ThiF family K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000001198 118.0
TLS2_k127_1974154_8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.0000000000000000000000002709 113.0
TLS2_k127_1974154_9 2 iron, 2 sulfur cluster binding K04487,K13643 - 2.8.1.7 0.000000000000000000002309 98.0
TLS2_k127_1976386_0 Alanine racemase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 304.0
TLS2_k127_1976386_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000005375 179.0
TLS2_k127_1976386_2 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.0000000000000000000000000005205 117.0
TLS2_k127_1979672_0 radical SAM K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 511.0
TLS2_k127_1979672_1 Belongs to the hyi family K01816 - 5.3.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 353.0
TLS2_k127_1979672_2 - K13486 - - 0.0000000000000000000000000000001546 138.0
TLS2_k127_1979672_3 Endonuclease Exonuclease Phosphatase - - - 0.0001619 49.0
TLS2_k127_1992388_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179,K08941 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 550.0
TLS2_k127_1992388_1 Indolepyruvate K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000001438 197.0
TLS2_k127_1992388_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000009303 98.0
TLS2_k127_1993591_0 Sigma-70, region 4 type 2 - - - 0.000000000000000000000000000000000000000000000000000002276 199.0
TLS2_k127_1993591_1 Histidine kinase K07683 - 2.7.13.3 0.000000000000000000000000000000000000000000005948 183.0
TLS2_k127_1997166_0 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 614.0
TLS2_k127_1997166_1 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.000000000000000000000000000299 123.0
TLS2_k127_1997166_2 YeeE YedE family K07112 - - 0.000000000000000000000000000989 118.0
TLS2_k127_2001199_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000001311 207.0
TLS2_k127_2001532_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 531.0
TLS2_k127_2001532_1 methionine gamma-lyase K01761 - 4.4.1.11 0.000000000000129 75.0
TLS2_k127_2002523_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 545.0
TLS2_k127_2002523_1 Sodium Bile acid symporter family K03453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 362.0
TLS2_k127_2002523_2 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000006042 136.0
TLS2_k127_2002523_3 Xylose isomerase-like TIM barrel - - - 0.000003965 49.0
TLS2_k127_2007376_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 567.0
TLS2_k127_2007376_1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042,K17468 - 2.9.1.1,4.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009354 391.0
TLS2_k127_2007376_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000001938 213.0
TLS2_k127_2007376_3 Cold-shock DNA-binding domain protein K03704 - - 0.000000000000000000000006164 104.0
TLS2_k127_2008666_0 Bacterial extracellular solute-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000004425 216.0
TLS2_k127_2008666_1 molybdate abc transporter K02018,K15496 - - 0.000000000000000000000000000000000000000000000000000001134 194.0
TLS2_k127_2014519_0 Peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000001056 218.0
TLS2_k127_2014519_1 Psort location OuterMembrane, score - - - 0.00002213 57.0
TLS2_k127_2014519_2 Belongs to the peptidase S1C family K04691,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - 0.0001095 50.0
TLS2_k127_2020907_0 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 505.0
TLS2_k127_2020907_1 COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog - - - 0.0000000000000000000000000000000000000217 150.0
TLS2_k127_2020907_2 ECF sigma factor - - - 0.000000000000000000000000000000698 124.0
TLS2_k127_2020907_3 Required for transformation and DNA binding K02245,K02456 GO:0005575,GO:0005623,GO:0005886,GO:0009986,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000001403 87.0
TLS2_k127_2020907_4 ECF sigma factor - - - 0.000000000000002274 79.0
TLS2_k127_2032930_0 carboxylic acid catabolic process K01187 - 3.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 612.0
TLS2_k127_2032930_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 452.0
TLS2_k127_2032930_2 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 405.0
TLS2_k127_2032930_3 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000004529 192.0
TLS2_k127_2041157_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 392.0
TLS2_k127_2041157_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000001359 199.0
TLS2_k127_2041157_2 DegT/DnrJ/EryC1/StrS aminotransferase family K13010,K19715 - 2.6.1.102,2.6.1.109 0.0000000000000000208 89.0
TLS2_k127_2044938_0 GHMP kinase K05305 - 2.7.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 536.0
TLS2_k127_2044938_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 417.0
TLS2_k127_2044938_2 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 353.0
TLS2_k127_2044938_3 Dimerisation domain of Zinc Transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009566 320.0
TLS2_k127_2048042_0 SIS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 298.0
TLS2_k127_2048042_1 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002481 277.0
TLS2_k127_2048042_2 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000559 272.0
TLS2_k127_2048042_3 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000001471 228.0
TLS2_k127_2048042_4 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000002401 166.0
TLS2_k127_2048042_5 Radical SAM superfamily K04069 - 1.97.1.4 0.0000000000000007035 78.0
TLS2_k127_2070659_0 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000005303 215.0
TLS2_k127_2070659_1 PIN domain - - - 0.00000000000000000000000000000001216 128.0
TLS2_k127_2070659_2 - - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0000000000000000000000000534 110.0
TLS2_k127_2072831_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009648 538.0
TLS2_k127_2072831_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 375.0
TLS2_k127_2072831_2 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 315.0
TLS2_k127_2072831_3 Dehydrogenase K00030,K00052 - 1.1.1.41,1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000001061 233.0
TLS2_k127_2072831_4 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000001397 176.0
TLS2_k127_2072831_5 protein possibly involved in utilization of glycolate and propanediol - - - 0.00000000000000000000000000000000000000002883 158.0
TLS2_k127_2072831_6 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000000000000000007977 161.0
TLS2_k127_2072831_7 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000005237 159.0
TLS2_k127_2072831_8 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000287 89.0
TLS2_k127_2077414_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 544.0
TLS2_k127_2077414_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 399.0
TLS2_k127_2077414_2 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002631 278.0
TLS2_k127_2077414_3 6-phosphogluconolactonase glucosamine-6-phosphate isomerase deaminase K02564 - 3.5.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000002396 250.0
TLS2_k127_2077414_4 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000000000008512 139.0
TLS2_k127_2077414_5 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000001561 139.0
TLS2_k127_2077414_6 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000001374 115.0
TLS2_k127_2077414_7 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000006715 111.0
TLS2_k127_2079043_0 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 330.0
TLS2_k127_2079043_1 Putative modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 331.0
TLS2_k127_2079043_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000533 302.0
TLS2_k127_2079043_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 296.0
TLS2_k127_2079043_4 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000003962 244.0
TLS2_k127_2079043_5 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000002142 195.0
TLS2_k127_2079043_6 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0001088 45.0
TLS2_k127_2092474_0 Oligoendopeptidase f - - - 6.259e-219 698.0
TLS2_k127_2092474_1 Belongs to the glycosyl hydrolase 2 family - - - 3.092e-213 694.0
TLS2_k127_2092474_2 Belongs to the UbiD family K03182 - 4.1.1.98 5.552e-209 659.0
TLS2_k127_2092474_3 Sodium:solute symporter family K14392 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 315.0
TLS2_k127_2092474_4 Domain of unknown function (DUF4162) K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000655 258.0
TLS2_k127_2092474_5 Peptidase family M23 K21472 - - 0.0000000000000000000000000000000000000000000000000000000013 205.0
TLS2_k127_2092474_6 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000004188 197.0
TLS2_k127_2092474_7 HEAT repeat - - - 0.00008775 55.0
TLS2_k127_2092474_8 BAAT Acyl-CoA thioester hydrolase - - - 0.0002864 53.0
TLS2_k127_2098169_0 PFAM Neutral alkaline nonlysosomal ceramidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 602.0
TLS2_k127_2098169_1 Neutral/alkaline non-lysosomal ceramidase, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008781 411.0
TLS2_k127_2098169_2 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 353.0
TLS2_k127_2098169_3 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 324.0
TLS2_k127_2098169_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000006282 75.0
TLS2_k127_209956_0 Glycosyl Hydrolase Family 88 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 466.0
TLS2_k127_209956_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003201 293.0
TLS2_k127_209956_2 regulation of RNA biosynthetic process K03567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000006682 120.0
TLS2_k127_2109680_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000001847 236.0
TLS2_k127_2109680_1 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000005344 176.0
TLS2_k127_2109680_2 DoxX K16937 - 1.8.5.2 0.0000000000008977 80.0
TLS2_k127_2110358_0 PFAM peptidase U34 dipeptidase - - - 6.319e-225 715.0
TLS2_k127_2110358_1 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 460.0
TLS2_k127_2110358_2 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 373.0
TLS2_k127_2110358_3 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000006379 196.0
TLS2_k127_2114026_0 Zinc carboxypeptidase - - - 5.425e-216 700.0
TLS2_k127_2115041_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 445.0
TLS2_k127_2115041_1 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000005573 146.0
TLS2_k127_2125017_0 - - - - 0.0 1043.0
TLS2_k127_2125017_1 Cytochrome c3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 448.0
TLS2_k127_2125017_2 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 308.0
TLS2_k127_2126035_0 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K19715 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0016051,GO:0043170,GO:0044238,GO:0071704,GO:1901576 2.6.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 324.0
TLS2_k127_2126035_1 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000211 248.0
TLS2_k127_2126035_2 ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000003428 242.0
TLS2_k127_2126035_3 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.00000000000000000000000000000000000000002161 164.0
TLS2_k127_2126035_4 converts alpha-aldose to the beta-anomer - - - 0.00000000000000000000007355 109.0
TLS2_k127_2126035_5 transport - - - 0.00000000000003331 80.0
TLS2_k127_2137207_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 353.0
TLS2_k127_2137207_1 Arginase family K01476 - 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 324.0
TLS2_k127_2137207_2 UPF0182 protein K09118 - - 0.00000000000000000000000000000000000000000000000000000000000000000001584 239.0
TLS2_k127_2137207_3 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000003863 124.0
TLS2_k127_2137911_0 amino acid-binding ACT domain protein K14170 - 4.2.1.51,5.4.99.5 5.748e-204 639.0
TLS2_k127_2137911_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 2.724e-201 634.0
TLS2_k127_2137911_2 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 434.0
TLS2_k127_2137911_3 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 292.0
TLS2_k127_2137911_4 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.000000000000000000000000000000000921 131.0
TLS2_k127_2145923_0 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 530.0
TLS2_k127_2145923_1 Zn_pept - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 411.0
TLS2_k127_2154262_0 PFAM ferredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 501.0
TLS2_k127_2154262_1 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005351 365.0
TLS2_k127_2154262_2 CO dehydrogenase acetyl-CoA synthase delta subunit K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008837 301.0
TLS2_k127_2154262_3 methionine synthase K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001093 286.0
TLS2_k127_2154262_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000004989 243.0
TLS2_k127_2154262_5 DinB family - - - 0.00000000000000000000000000000000000000009322 155.0
TLS2_k127_2154262_6 Xylose isomerase-like TIM barrel K03079 - 5.1.3.22 0.0000000000000000000000000000000003697 134.0
TLS2_k127_2158552_0 TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - 0.00000000000000001123 91.0
TLS2_k127_2158552_1 peptidase M15B and M15C DD-carboxypeptidase VanY - - - 0.0000000003503 67.0
TLS2_k127_2171237_0 Transketolase b K00615 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031935,GO:0033043,GO:0033044,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0060968,GO:0065007,GO:0080090,GO:1902275,GO:1903506,GO:2000112,GO:2001141 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 373.0
TLS2_k127_2171237_1 The glycine cleavage system catalyzes the degradation of glycine K00605,K06980,K22086 - 1.5.99.5,2.1.2.10 0.0000000000000000000000000000000000000000000005066 179.0
TLS2_k127_2171237_2 Tetratrico peptide repeat - - - 0.00008193 51.0
TLS2_k127_2175152_0 BNR repeat-like domain - - - 0.000000000000000000000000000005129 134.0
TLS2_k127_2175152_1 Major facilitator superfamily - - - 0.0000000123 66.0
TLS2_k127_2177938_0 PFAM TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003247 317.0
TLS2_k127_2177938_1 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000001118 180.0
TLS2_k127_2179327_0 Peptidase S46 - - - 5.054e-252 790.0
TLS2_k127_2179327_1 Sucrose-6F-phosphate phosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 335.0
TLS2_k127_2179518_0 Glycogen debranching enzyme N terminal - - - 1.693e-221 701.0
TLS2_k127_2179518_1 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 354.0
TLS2_k127_2179839_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 2.777e-229 719.0
TLS2_k127_2179839_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 594.0
TLS2_k127_2179839_10 ABC transporter, ATP-binding protein K02003 - - 0.00000000000001733 76.0
TLS2_k127_2179839_2 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 566.0
TLS2_k127_2179839_3 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 307.0
TLS2_k127_2179839_4 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 291.0
TLS2_k127_2179839_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000008854 248.0
TLS2_k127_2179839_6 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000212 185.0
TLS2_k127_2179839_7 cell septum assembly - - - 0.000000000000000000000000000000000000006422 164.0
TLS2_k127_2179839_8 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000001974 134.0
TLS2_k127_2179839_9 CDP-alcohol phosphatidyltransferase K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000001927 133.0
TLS2_k127_2194709_0 Domain of unknown function K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 323.0
TLS2_k127_2194709_1 Cellulase N-terminal ig-like domain - - - 0.000000000000000000000000000000000000000916 150.0
TLS2_k127_2194709_2 Surface antigen - - - 0.000000000000000000000000000000000000724 150.0
TLS2_k127_2212733_0 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000003613 197.0
TLS2_k127_2212733_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000057 119.0
TLS2_k127_2212733_2 Peptidoglycan-binding domain 1 protein K07273 - - 0.0000000001224 74.0
TLS2_k127_22328_0 all-trans-retinol 13,14-reductase activity K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 456.0
TLS2_k127_22328_1 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 302.0
TLS2_k127_22328_2 cAMP biosynthetic process - - - 0.0000001214 55.0
TLS2_k127_223825_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - - 5.597e-232 729.0
TLS2_k127_223825_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 1.112e-215 684.0
TLS2_k127_223825_2 translation release factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005651 283.0
TLS2_k127_223825_3 PFAM Universal stress protein family K06149 - - 0.00000000000000000001696 97.0
TLS2_k127_2257107_0 PFAM Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 314.0
TLS2_k127_2257107_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000001066 209.0
TLS2_k127_2275997_0 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 2.752e-198 625.0
TLS2_k127_2275997_1 Nucleotidyl transferase K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000003473 185.0
TLS2_k127_2275997_2 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000009549 170.0
TLS2_k127_2275997_3 CYTH K05873 - 4.6.1.1 0.00000000000000001485 86.0
TLS2_k127_2280521_0 PFAM AMP-dependent synthetase and ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 635.0
TLS2_k127_2280521_1 nodulation K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 493.0
TLS2_k127_2280521_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 431.0
TLS2_k127_2280521_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 307.0
TLS2_k127_2280521_4 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000656 249.0
TLS2_k127_2280521_5 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000482 191.0
TLS2_k127_2280521_6 Glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000002099 162.0
TLS2_k127_2281921_0 Stage II sporulation protein E K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001179 281.0
TLS2_k127_2281921_1 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001284 263.0
TLS2_k127_2281921_2 Metalloenzyme superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000001095 229.0
TLS2_k127_2281921_3 Belongs to the ompA family K03640 - - 0.000000000000000000000000005213 124.0
TLS2_k127_2281921_4 DNA photolyase activity K03716 - 4.1.99.14 0.00000000000176 69.0
TLS2_k127_2286803_0 COG2706 3-carboxymuconate cyclase K07404 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 420.0
TLS2_k127_2286803_1 phosphoprotein phosphatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002157 271.0
TLS2_k127_2286803_2 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000001526 135.0
TLS2_k127_2303913_0 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005137 258.0
TLS2_k127_2303913_1 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008775 263.0
TLS2_k127_2303913_2 CDP-alcohol phosphatidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001422 228.0
TLS2_k127_2303913_3 Domain of unknown function (DUF4126) - - - 0.0000000000000000000000000000000000000000000000001997 183.0
TLS2_k127_2303913_5 GtrA-like protein - - - 0.00000000000000000162 94.0
TLS2_k127_2303913_6 Heparinase - - - 0.0000000000002422 74.0
TLS2_k127_2303913_7 Soluble lytic murein transglycosylase-like protein - - - 0.0000000007425 68.0
TLS2_k127_2310065_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 1.838e-256 834.0
TLS2_k127_2310065_1 cellulose binding - - - 0.00000000000000000000000000000000000000000000000202 176.0
TLS2_k127_2310065_2 response regulator K07689 - - 0.000000000000000000000000001837 118.0
TLS2_k127_2310065_3 Histidine kinase - - - 0.0000000000000000002709 92.0
TLS2_k127_2323571_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 522.0
TLS2_k127_2323571_1 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001601 269.0
TLS2_k127_2323571_2 L-lactate permease K03303 - - 0.0000000000000000000000000000000154 130.0
TLS2_k127_232454_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 370.0
TLS2_k127_232454_1 Domain of unknown function (DUF3488) - - - 0.0000000000000000000000000000000000000000000000000000000002414 225.0
TLS2_k127_232454_2 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000972 136.0
TLS2_k127_2340441_0 COGs COG1620 L-lactate permease K03303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 392.0
TLS2_k127_2340441_1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 389.0
TLS2_k127_2340441_2 antibiotic biosynthetic process K01434 - 3.5.1.11 0.00000000000000000000000000000000000001221 146.0
TLS2_k127_2346728_0 Alpha/beta hydrolase family K18092 - - 0.0000000000000000000000000000000000000000004276 160.0
TLS2_k127_2346728_1 - - - - 0.000000000000000000000000000000005318 148.0
TLS2_k127_2348172_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005581 627.0
TLS2_k127_2348172_1 Aspartyl protease - - - 0.000000000000000000000000000000000000000000007391 179.0
TLS2_k127_2348172_2 FCD - - - 0.000000000000000000000000000000000000001239 156.0
TLS2_k127_2348172_3 COG1943 Transposase and inactivated derivatives - - - 0.0004981 44.0
TLS2_k127_2355174_0 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 446.0
TLS2_k127_2355174_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 336.0
TLS2_k127_2355174_2 Biotin-requiring enzyme - - - 0.00000000002073 72.0
TLS2_k127_2361791_0 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 2.416e-207 656.0
TLS2_k127_2362248_0 DegT/DnrJ/EryC1/StrS aminotransferase family K13010,K19715 - 2.6.1.102,2.6.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008512 420.0
TLS2_k127_2362248_1 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000003444 183.0
TLS2_k127_2362248_2 Amp-dependent synthetase and ligase K00797,K01897 - 2.5.1.16,6.2.1.3 0.000003068 51.0
TLS2_k127_2362248_3 Cupin domain - - - 0.0000058 54.0
TLS2_k127_2362337_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005095 451.0
TLS2_k127_2362391_0 PFAM RNA-binding protein AU-1 Ribonuclease E G K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006545 546.0
TLS2_k127_2362391_1 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003926 264.0
TLS2_k127_2364975_0 Response regulator receiver - - - 5.893e-203 640.0
TLS2_k127_2364975_1 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009962 372.0
TLS2_k127_2364975_2 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 347.0
TLS2_k127_2364975_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000613 229.0
TLS2_k127_2364975_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000126 205.0
TLS2_k127_2380030_0 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 357.0
TLS2_k127_2380030_1 Lipopolysaccharide-assembly - - - 0.00000000000000000000128 100.0
TLS2_k127_2380030_2 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000000000002422 88.0
TLS2_k127_2380030_3 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.00000000001365 75.0
TLS2_k127_2380030_4 Belongs to the arginase family K01476 - 3.5.3.1 0.0004217 42.0
TLS2_k127_2398143_0 unfolded protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 481.0
TLS2_k127_2398143_1 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006109 359.0
TLS2_k127_240182_0 lysine 2,3-aminomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 586.0
TLS2_k127_240182_1 ATP-grasp domain K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 423.0
TLS2_k127_240182_2 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005063 296.0
TLS2_k127_2411859_0 Pfam Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 489.0
TLS2_k127_2411859_1 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000001012 172.0
TLS2_k127_2411859_2 membrane protein of uknown function UCP014873 - - - 0.0000000000000000000000000000271 124.0
TLS2_k127_2419671_0 Glycogen debranching enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006245 285.0
TLS2_k127_2419671_1 beta-fructofuranosidase activity - - - 0.000000000000000000000000000000000000000003298 168.0
TLS2_k127_2419671_2 single-species biofilm formation - - - 0.0000000000000000000000000000000172 131.0
TLS2_k127_2432324_0 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000001903 186.0
TLS2_k127_2432324_1 - - - - 0.000000000000000000000000000000000000000000004032 176.0
TLS2_k127_2432324_2 acetyltransferase - - - 0.000000000000000000001253 103.0
TLS2_k127_2444721_0 Protein of unknown function (DUF2961) - - - 4.613e-194 610.0
TLS2_k127_2444721_1 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 368.0
TLS2_k127_2459306_0 PFAM Cytochrome C assembly protein K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 612.0
TLS2_k127_2459306_1 Cytochrome c assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007029 256.0
TLS2_k127_2459306_2 ABC transporter K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000000000005215 226.0
TLS2_k127_2459306_3 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.00000000000000000000000000000000000000000001638 170.0
TLS2_k127_2459306_4 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000001328 92.0
TLS2_k127_2459306_5 subunit of a heme lyase K02200 - - 0.00000000000001188 81.0
TLS2_k127_2459306_6 von Willebrand factor, type A - - - 0.0000005427 61.0
TLS2_k127_2459306_7 zinc-ribbon domain - - - 0.00004446 49.0
TLS2_k127_2471262_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 445.0
TLS2_k127_2471262_1 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000001207 164.0
TLS2_k127_2471262_2 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000002206 113.0
TLS2_k127_2471262_3 FeS cluster assembly scaffold protein NifU K04488 - - 0.000000000002803 71.0
TLS2_k127_2491152_0 Domain of unknown function (DUF5107) - - - 1.341e-198 636.0
TLS2_k127_2491152_1 Beta-galactosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009257 317.0
TLS2_k127_2491152_2 - - - - 0.0000000000000000000000000000000000000000001583 167.0
TLS2_k127_2496450_0 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 544.0
TLS2_k127_2496450_1 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 366.0
TLS2_k127_2496450_2 N-acetylglucosaminylinositol deacetylase activity K01463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000047 319.0
TLS2_k127_2496450_3 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001206 269.0
TLS2_k127_2496450_4 redox protein regulator of disulfide bond formation K06889,K07397 - - 0.000000000000000000000000000000000000000000000000000003676 202.0
TLS2_k127_2496450_5 MotA TolQ ExbB proton channel family K03561 - - 0.000000000000000000000000000000000005676 145.0
TLS2_k127_2496450_6 RNA polymerase sigma factor K03088 - - 0.0000000000000001203 82.0
TLS2_k127_2496450_7 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.0000000000002886 75.0
TLS2_k127_2496450_8 cellular component assembly - - - 0.000000000008588 76.0
TLS2_k127_2496450_9 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.00000000005068 69.0
TLS2_k127_2502165_0 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 477.0
TLS2_k127_2502165_1 Cytochrome c554 and c-prime K03620 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 368.0
TLS2_k127_2502165_2 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.00000000000000000000000000000000000000000000000000000004275 199.0
TLS2_k127_2502165_3 With GlrK is part of a two-component signal transduction system regulating glmY K07715 - - 0.0006046 44.0
TLS2_k127_2504375_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 394.0
TLS2_k127_2504375_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002408 229.0
TLS2_k127_2507627_0 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 492.0
TLS2_k127_2507627_1 3-demethylubiquinone-9 3-methyltransferase K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 312.0
TLS2_k127_2507627_10 - - - - 0.000009705 49.0
TLS2_k127_2507627_11 Aldolase K01625 - 4.1.2.14,4.1.3.42 0.00002557 46.0
TLS2_k127_2507627_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000004289 220.0
TLS2_k127_2507627_3 long-chain fatty acid transporting porin activity K06076 - - 0.0000000000000000000000000000000000000000000000000000000006176 217.0
TLS2_k127_2507627_4 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000002017 190.0
TLS2_k127_2507627_5 COG0642 Signal transduction histidine kinase K07698 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.0000000000000000000000002042 110.0
TLS2_k127_2507627_6 HDOD domain - - - 0.000000000000000000004109 107.0
TLS2_k127_2507627_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11354 - 2.7.13.3 0.000000000000000000372 100.0
TLS2_k127_2507627_8 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000006691 87.0
TLS2_k127_2507627_9 Member of the two-component regulatory system MprB MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region K07669,K07672 GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000000000003389 79.0
TLS2_k127_250786_0 Pfam:KaiC K08482 - - 2.347e-220 700.0
TLS2_k127_250786_1 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 456.0
TLS2_k127_250786_2 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 431.0
TLS2_k127_250786_3 PFAM Phenazine biosynthesis PhzC PhzF protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 336.0
TLS2_k127_250786_4 KaiB K08481 - - 0.000000000000000000000000000000000000000009648 157.0
TLS2_k127_250786_5 KaiB K08481 - - 0.0000000000000000000000000000000000698 136.0
TLS2_k127_250786_6 Histidine kinase - - - 0.00000000000000000000000000002166 124.0
TLS2_k127_250786_7 cytochrome C oxidase mono-heme subunit FixO K00405 - - 0.00001219 52.0
TLS2_k127_2519361_0 beta-fructofuranosidase activity - - - 9.114e-199 632.0
TLS2_k127_2519361_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K18983 - 5.5.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 518.0
TLS2_k127_2519361_2 PFAM D-isomer specific 2-hydroxyacid dehydrogenase K12972 - 1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 364.0
TLS2_k127_2523618_0 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 6.76e-239 751.0
TLS2_k127_2523618_1 LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006209 253.0
TLS2_k127_2523618_2 PFAM cobalamin B12-binding domain protein K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000008007 172.0
TLS2_k127_2523618_3 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000007554 119.0
TLS2_k127_2533215_0 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K08641,K11206 - 3.4.13.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 316.0
TLS2_k127_2533215_1 Domain of unknown function (DUF4185) - - - 0.00000000000000000000000002063 126.0
TLS2_k127_2535366_0 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 1.363e-194 641.0
TLS2_k127_2535366_1 PFAM Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 365.0
TLS2_k127_2535366_2 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000005607 205.0
TLS2_k127_2535366_3 Belongs to the peptidase S41A family K03797,K11749 - 3.4.21.102 0.0000000000000000001929 100.0
TLS2_k127_2535366_4 extracellular matrix structural constituent - - - 0.000000008414 68.0
TLS2_k127_2535366_5 - - - - 0.000002321 50.0
TLS2_k127_2547322_0 Protein of unknown function (DUF1501) - - - 1.625e-205 649.0
TLS2_k127_2547322_1 transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007607 360.0
TLS2_k127_2547322_2 Cytochrome c, class I - - - 0.000000000008874 66.0
TLS2_k127_2547729_0 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 468.0
TLS2_k127_2547729_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 415.0
TLS2_k127_2547729_2 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000002724 189.0
TLS2_k127_2548592_0 metallopeptidase activity - - - 0.000000000000002039 91.0
TLS2_k127_2548592_1 Two component regulator propeller - - - 0.0000000000001393 74.0
TLS2_k127_2548592_2 Outer membrane protein beta-barrel domain - - - 0.000000000101 75.0
TLS2_k127_2548592_3 CAAX protease self-immunity K07052 - - 0.000003709 58.0
TLS2_k127_2551426_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 2.844e-242 771.0
TLS2_k127_2551426_1 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000001355 147.0
TLS2_k127_2551426_2 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000008945 136.0
TLS2_k127_2551426_3 Ribosomal-protein-alanine acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 0.0000000000000000468 89.0
TLS2_k127_2561469_0 Predicted permease YjgP/YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 432.0
TLS2_k127_2561469_1 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000000000000000001724 144.0
TLS2_k127_256766_0 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 475.0
TLS2_k127_256766_1 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000121 231.0
TLS2_k127_256766_2 response to oxidative stress K04063 - - 0.0000000000000000000000000000008183 128.0
TLS2_k127_2574371_0 Putative glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000516 283.0
TLS2_k127_2574371_1 sequence-specific DNA binding - - - 0.0000003951 59.0
TLS2_k127_2574371_2 PIN domain - - - 0.000004436 49.0
TLS2_k127_2586158_0 PFAM Acetyl xylan esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 515.0
TLS2_k127_2586158_1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002995 288.0
TLS2_k127_2586158_2 COGs COG0673 dehydrogenase and related protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000204 290.0
TLS2_k127_2586158_3 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002282 269.0
TLS2_k127_2586158_4 - - - - 0.000000000000000000000000000000000000000000000000005293 186.0
TLS2_k127_2586158_5 Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - 0.000000000000000000000000000000000000000000000001997 192.0
TLS2_k127_2586158_6 pyridoxamine 5'-phosphate K07005 - - 0.0000009689 59.0
TLS2_k127_2588670_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 515.0
TLS2_k127_2588670_1 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 385.0
TLS2_k127_2588670_2 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001605 249.0
TLS2_k127_2592473_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 298.0
TLS2_k127_2592473_1 transcription activator K03707 - 3.5.99.2 0.00000000000000000000000000000000000000000000000000008013 195.0
TLS2_k127_2592473_2 Beta-L-arabinofuranosidase, GH127 K09955 - - 0.000000000000000000000000000000000000006633 166.0
TLS2_k127_259741_0 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 592.0
TLS2_k127_259741_1 epimerase - - - 0.00000000000000000000000001626 110.0
TLS2_k127_259741_2 epimerase - - - 0.0000000000002927 70.0
TLS2_k127_2606848_0 Ompa motb domain protein - - - 0.0 1698.0
TLS2_k127_2606848_1 Domain of unknown function DUF11 - - - 0.00000000000000000000001222 100.0
TLS2_k127_2611417_0 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000327 182.0
TLS2_k127_2611417_1 amidohydrolase K07045 - - 0.00000000000000000000000000000009013 135.0
TLS2_k127_2611417_2 beta-fructofuranosidase activity - - - 0.0000000000000000000000000007293 126.0
TLS2_k127_2611417_3 BNR repeat-like domain - - - 0.00000003107 66.0
TLS2_k127_2623968_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 489.0
TLS2_k127_2623968_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 460.0
TLS2_k127_2623968_2 ATP synthesis coupled electron transport K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 392.0
TLS2_k127_2623968_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005812 341.0
TLS2_k127_2623968_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000001075 234.0
TLS2_k127_2623968_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000001221 207.0
TLS2_k127_2623968_6 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.00000000000000000000000000000000000005326 150.0
TLS2_k127_2623968_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000001536 102.0
TLS2_k127_2623968_8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000005035 63.0
TLS2_k127_2629162_0 amino acid K03294,K19540 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 443.0
TLS2_k127_2629162_1 Sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004355 400.0
TLS2_k127_2629162_2 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 313.0
TLS2_k127_2629162_3 - - - - 0.000000000000000000000000001299 128.0
TLS2_k127_2648833_0 oxidoreductase activity K07114 - - 0.00000000000000000008309 104.0
TLS2_k127_2648833_1 Tetratricopeptide repeat - - - 0.000000000000001269 85.0
TLS2_k127_2655714_0 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 387.0
TLS2_k127_2655714_1 Protein of unknown function (DUF4230) - - - 0.00000000000000000000000000000000000000000000207 172.0
TLS2_k127_2665621_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 1.132e-320 998.0
TLS2_k127_2665621_1 Transcriptional regulator K03717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 330.0
TLS2_k127_267001_0 Iron-containing alcohol dehydrogenase K00001,K01714,K13954 - 1.1.1.1,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000307 226.0
TLS2_k127_267001_1 MFS_1 like family - - - 0.000000000000000000000000000001171 125.0
TLS2_k127_267001_2 - - - - 0.000000000000000000000000000001491 124.0
TLS2_k127_267001_3 Belongs to the peptidase S8 family K13276,K17734 - - 0.0000000003461 73.0
TLS2_k127_267001_4 Tfp pilus assembly protein FimV - - - 0.0005153 50.0
TLS2_k127_2673630_0 Putative esterase K07214 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 472.0
TLS2_k127_2673630_1 Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 380.0
TLS2_k127_2673630_2 Xylose isomerase-like TIM barrel K03335 - 4.2.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 303.0
TLS2_k127_2673630_3 BMC - - - 0.00000000000000000000000000000000000000000007274 168.0
TLS2_k127_2673630_4 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000000000000004737 116.0
TLS2_k127_2679873_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 468.0
TLS2_k127_2679873_1 thiolester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 420.0
TLS2_k127_2679873_2 PFAM DNA mismatch repair protein MutS domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000577 286.0
TLS2_k127_2679873_3 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000164 280.0
TLS2_k127_2679873_4 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.000000000000000000000000000000000000000000000000000000000003221 223.0
TLS2_k127_2679873_5 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000002383 191.0
TLS2_k127_26806_0 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000004487 180.0
TLS2_k127_2686837_0 2-epimerase K16213 - 5.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 457.0
TLS2_k127_2686837_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006599 284.0
TLS2_k127_2686837_2 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000007438 241.0
TLS2_k127_2686837_3 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000001273 167.0
TLS2_k127_2686837_4 Tetratricopeptide repeat - - - 0.0000004539 61.0
TLS2_k127_2692657_0 Baseplate J-like protein - - - 0.0000000000000000000000000000000000000000000000000000003266 199.0
TLS2_k127_2692657_1 Phage tail protein (Tail_P2_I) - - - 0.000000000000000000000000000000000000000000000000000001071 197.0
TLS2_k127_2692657_2 - - - - 0.00000000000000000003392 104.0
TLS2_k127_2692657_3 serine threonine protein kinase K03587,K08884,K12132 - 2.7.11.1,3.4.16.4 0.00000000000000000422 98.0
TLS2_k127_2692657_4 Kinase domain K12132 - 2.7.11.1 0.0000000002811 73.0
TLS2_k127_2697600_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 597.0
TLS2_k127_2697600_1 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000009451 181.0
TLS2_k127_2697600_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000003791 90.0
TLS2_k127_2697600_3 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00000000000000002282 87.0
TLS2_k127_2697600_4 iron-nicotianamine transmembrane transporter activity - GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 0.000000000004625 66.0
TLS2_k127_2706831_0 COG1680 Beta-lactamase class C and other penicillin binding - - - 0.000000000000000000000000000000000000000000000009125 189.0
TLS2_k127_2706831_1 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.000000000000000000000000002513 116.0
TLS2_k127_2711149_0 PFAM Carbohydrate kinase K00853 - 2.7.1.16 4.95e-248 775.0
TLS2_k127_2711149_1 L-fucose isomerase, C-terminal domain - - - 3.73e-230 720.0
TLS2_k127_2711149_2 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 456.0
TLS2_k127_2711149_3 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006477 393.0
TLS2_k127_2711149_4 Kinase, PfkB family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000002235 252.0
TLS2_k127_2711149_5 oxidation-reduction process - - - 0.00000000000000000000000000000000000000000000407 179.0
TLS2_k127_2711149_6 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000000000000000007326 148.0
TLS2_k127_2711149_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.00000000000000000000000000007027 128.0
TLS2_k127_2711149_8 Putative phosphatase (DUF442) - - - 0.000000000000001267 84.0
TLS2_k127_2711149_9 Putative regulatory protein - - - 0.0000000000005495 71.0
TLS2_k127_2718937_0 Catalase K03781 - 1.11.1.6 0.0 1007.0
TLS2_k127_2718937_1 Nitrite and sulphite reductase 4Fe-4S domain K00392 - 1.8.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 297.0
TLS2_k127_2718937_2 Tetrapyrrole (Corrin/Porphyrin) Methylases K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000001987 262.0
TLS2_k127_2718937_3 TIGRFAM siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.000000000000000000000000000000001183 138.0
TLS2_k127_2719947_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006045 343.0
TLS2_k127_2719947_1 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000000000000000003299 219.0
TLS2_k127_2719947_2 Outer membrane lipoprotein-sorting protein - - - 0.00000000004446 73.0
TLS2_k127_2720109_0 chlorophyll binding - - - 0.0000000000000000000000000000000003262 139.0
TLS2_k127_2720109_1 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000321 141.0
TLS2_k127_2720109_2 - - - - 0.0000000000000000144 87.0
TLS2_k127_2723685_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 609.0
TLS2_k127_2723685_1 Tricorn protease homolog - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 409.0
TLS2_k127_2725697_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 340.0
TLS2_k127_2739219_0 Domain of unknown function (DUF5107) - - - 4.557e-266 855.0
TLS2_k127_2739219_1 acid phosphatase activity K14379 - 3.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002746 286.0
TLS2_k127_2739219_2 transport - - - 0.00000000000000000000000000000000000002306 151.0
TLS2_k127_2742199_0 Glycosyl hydrolases family 2 - - - 0.0 1032.0
TLS2_k127_2742199_1 cystathionine K01760,K17217 GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008284,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0042127,GO:0043418,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0048518,GO:0048522,GO:0050667,GO:0050789,GO:0050794,GO:0065007,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.4.1.1,4.4.1.2,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 450.0
TLS2_k127_2742199_2 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 417.0
TLS2_k127_2742199_3 Belongs to the glycosyl hydrolase 57 family - - - 0.00000000000000000000000000000000000000003084 153.0
TLS2_k127_2742199_4 histone H2A-K13 ubiquitination K01338,K07157 - 3.4.21.53 0.000000000000000000000000000001184 131.0
TLS2_k127_2743873_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1050.0
TLS2_k127_2743873_1 Sodium:solute symporter family - - - 4.8e-307 949.0
TLS2_k127_2743873_2 Putative glutamine amidotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009183 392.0
TLS2_k127_2743873_3 - - - - 0.00000000000000005932 85.0
TLS2_k127_2743873_4 inositol 2-dehydrogenase activity - - - 0.000000000000003141 78.0
TLS2_k127_2743873_5 COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) K00917 - 2.7.1.144 0.0000000000002921 81.0
TLS2_k127_2746994_0 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 537.0
TLS2_k127_2746994_1 phosphoglycerate mutase - - - 0.00000000000000000000000000000000000000000000000000000000001921 216.0
TLS2_k127_2750523_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 578.0
TLS2_k127_2750523_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000008827 111.0
TLS2_k127_2756283_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005041 554.0
TLS2_k127_2756283_1 amine dehydrogenase activity K21449 - - 0.00000000000000000000000000000000000000000000000001305 185.0
TLS2_k127_2756283_2 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000003633 132.0
TLS2_k127_2756283_3 HAMP domain - - - 0.000000000000000000000001283 119.0
TLS2_k127_2756283_4 Protein conserved in bacteria - - - 0.0000000000000000000001767 106.0
TLS2_k127_2774092_0 DNA-templated transcription, initiation - - - 0.00000000000000000000000000000000000000000000000002473 193.0
TLS2_k127_2774092_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000001625 159.0
TLS2_k127_2774092_3 cytochrome C peroxidase K00428 - 1.11.1.5 0.000005166 48.0
TLS2_k127_2774578_0 dead deah K03724 - - 5.059e-292 912.0
TLS2_k127_2774578_1 PhoQ Sensor K07640 - 2.7.13.3 0.00000000001485 65.0
TLS2_k127_2779790_0 COGs COG0673 dehydrogenase and related protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002601 273.0
TLS2_k127_2779790_1 Protein of unknown function (DUF1593) - - - 0.00000000000000000000000000000000000000000000000000006899 192.0
TLS2_k127_2779790_2 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000001952 131.0
TLS2_k127_2779790_3 IMG reference gene - - - 0.000000000000000000000001372 115.0
TLS2_k127_2779790_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0007365 43.0
TLS2_k127_2783774_0 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004558 609.0
TLS2_k127_2783774_1 FRG - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 322.0
TLS2_k127_2783774_2 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member K03581 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000601 271.0
TLS2_k127_2783774_3 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000001638 265.0
TLS2_k127_2783774_4 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000004473 155.0
TLS2_k127_2783774_5 DoxX - - - 0.00000000000000000000000000000004069 130.0
TLS2_k127_2783774_6 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000000000007093 106.0
TLS2_k127_2784114_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 1.804e-203 642.0
TLS2_k127_2784114_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 532.0
TLS2_k127_2784114_2 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 407.0
TLS2_k127_2784114_3 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006519 407.0
TLS2_k127_2784114_4 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007438 367.0
TLS2_k127_2784114_5 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003945 252.0
TLS2_k127_2784114_6 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000004407 140.0
TLS2_k127_27845_0 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 441.0
TLS2_k127_27845_1 Peptidase M56 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001348 252.0
TLS2_k127_27845_2 - - - - 0.0000000000000000000000000000000000000000000000000000252 215.0
TLS2_k127_27845_3 Uroporphyrinogen decarboxylase (URO-D) - - - 0.000000000000000000000000002706 119.0
TLS2_k127_2786934_0 pathogenesis K12685,K19231 - - 0.0000000000000000000141 108.0
TLS2_k127_2790579_0 Domain of unknown function (DUF5060) - - - 0.0000000000000000000000000000002138 141.0
TLS2_k127_2802972_0 ABC transporter transmembrane region K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 463.0
TLS2_k127_2802972_1 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.00000000000000000000000000000000006019 139.0
TLS2_k127_2815865_0 Alpha-L-fucosidase K01206 - 3.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006763 305.0
TLS2_k127_2815865_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009639 287.0
TLS2_k127_2815865_2 Alginate lyase - - - 0.00000000000000000000000000000000000000000000000000002575 203.0
TLS2_k127_2815865_3 HNH endonuclease - - - 0.00000000001573 67.0
TLS2_k127_2830228_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000001727 194.0
TLS2_k127_2830228_1 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000001781 158.0
TLS2_k127_2834949_0 PFAM iron-containing alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 421.0
TLS2_k127_2834949_1 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000002616 261.0
TLS2_k127_2834949_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - - 0.0000000000000002196 87.0
TLS2_k127_2836731_0 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 469.0
TLS2_k127_2836731_1 Bacterial extracellular solute-binding protein K02048 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 398.0
TLS2_k127_2840249_0 PFAM NAD dependent epimerase dehydratase family K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008693 569.0
TLS2_k127_2840249_1 (ABC) transporter - - - 0.000000000000000000000000000000000000000000000000000009892 210.0
TLS2_k127_2846337_0 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 462.0
TLS2_k127_2846337_1 Aminotransferase class-III K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000004984 264.0
TLS2_k127_2850753_0 glycosyltransferase 36 associated K00702,K13688 - 2.4.1.20 4.025e-264 823.0
TLS2_k127_2851371_0 2-keto-3-deoxy-L-rhamnonate aldolase activity K00979,K01630,K02510 - 2.7.7.38,4.1.2.20,4.1.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007134 286.0
TLS2_k127_2851371_1 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000003325 207.0
TLS2_k127_2855117_0 SMART Elongator protein 3 MiaB NifB - - - 7.012e-241 755.0
TLS2_k127_2855117_1 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 584.0
TLS2_k127_2855117_2 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009082 419.0
TLS2_k127_2855117_3 PFAM transferase hexapeptide repeat containing protein K00661 - 2.3.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 334.0
TLS2_k127_2855117_5 protein involved in exopolysaccharide biosynthesis K16554 - - 0.0000000001916 72.0
TLS2_k127_2855296_0 Beta-L-arabinofuranosidase, GH127 K09955 - - 3.951e-236 747.0
TLS2_k127_2855296_1 PFAM RhaT l-rhamnose-proton symport 2 K02856 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 522.0
TLS2_k127_2855296_2 Glycosyl hydrolases family 28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 355.0
TLS2_k127_2855296_3 COG2335 Secreted and surface protein containing fasciclin-like repeats - - - 0.000000000000000000000000009617 115.0
TLS2_k127_2855296_4 COG2610 H gluconate symporter and related permeases K03299 - - 0.000000001951 62.0
TLS2_k127_2855332_0 von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 570.0
TLS2_k127_2855332_1 PFAM 2-nitropropane dioxygenase NPD K00459,K02371 - 1.13.12.16,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 361.0
TLS2_k127_2855332_2 Domain of unknown function (DUF386) - - - 0.0000000000000000000000001906 111.0
TLS2_k127_2857252_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006748 528.0
TLS2_k127_2857252_1 Belongs to the UPF0145 family - - - 0.000000000000000000000000000000000002044 140.0
TLS2_k127_2857252_2 Putative zinc-finger - - - 0.000000000000000004025 89.0
TLS2_k127_2857252_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000009769 66.0
TLS2_k127_2861598_0 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000134 199.0
TLS2_k127_2861598_1 Belongs to the glycosyl hydrolase 5 (cellulase A) family K19355 - 3.2.1.78 0.000000664 63.0
TLS2_k127_2862414_0 choline dehydrogenase activity - - - 5.029e-298 920.0
TLS2_k127_2862414_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000002385 179.0
TLS2_k127_2863301_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 398.0
TLS2_k127_2863301_1 6-phosphogluconolactonase activity - - - 0.000000000001661 75.0
TLS2_k127_2863301_2 alpha/beta hydrolase fold - - - 0.0000005665 55.0
TLS2_k127_2891143_0 SIS domain K03271 - 5.3.1.28 2.599e-215 687.0
TLS2_k127_2891143_1 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 474.0
TLS2_k127_2891143_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 458.0
TLS2_k127_2891143_3 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 299.0
TLS2_k127_2891143_4 Polynucleotide kinase 3 phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004486 250.0
TLS2_k127_2891143_5 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843 - - 0.000000000000000000000000000000000000000000000001766 177.0
TLS2_k127_2897182_0 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 335.0
TLS2_k127_2897182_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000006765 225.0
TLS2_k127_2897182_2 - - - - 0.00000000004131 70.0
TLS2_k127_2897182_3 Periplasmic or secreted lipoprotein - - - 0.00003094 54.0
TLS2_k127_2900416_0 TonB dependent receptor - - - 5.647e-206 676.0
TLS2_k127_2900416_1 Belongs to the DapA family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000455 278.0
TLS2_k127_2900416_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009887 252.0
TLS2_k127_2910589_0 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000604 356.0
TLS2_k127_2910589_1 Oxidoreductase family, C-terminal alpha/beta domain K13020 - 1.1.1.335 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003327 278.0
TLS2_k127_2911975_0 serine-type peptidase activity K08676 - - 0.0 1323.0
TLS2_k127_2911975_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 464.0
TLS2_k127_2911975_2 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000008137 208.0
TLS2_k127_2913239_0 BlaR1 peptidase M56 K02172 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006595 269.0
TLS2_k127_2913239_1 PFAM Penicillinase repressor K02171 - - 0.000000000000000000000003431 104.0
TLS2_k127_2914164_0 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 611.0
TLS2_k127_2914164_1 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000001904 226.0
TLS2_k127_2914164_2 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000003695 192.0
TLS2_k127_2914164_3 SMART regulatory protein ArsR - - - 0.0000000000000000000000000000004704 123.0
TLS2_k127_2914164_4 COG0526, thiol-disulfide isomerase and thioredoxins K02199 - - 0.000000000000000000000000000004529 128.0
TLS2_k127_2914164_5 Thioredoxin domain - - - 0.000000000000000005439 92.0
TLS2_k127_2921673_0 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 418.0
TLS2_k127_2921673_1 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 326.0
TLS2_k127_2921673_2 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000008582 248.0
TLS2_k127_2921673_3 - - - - 0.00000007152 59.0
TLS2_k127_2928029_0 protoporphyrinogen oxidase activity K01854,K07011 - 5.4.99.9 0.0 1092.0
TLS2_k127_2928029_1 Glycosyl transferase, family 2 - - - 6.061e-195 615.0
TLS2_k127_2929341_0 PFAM Uncharacterised protein family UPF0182 K09118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 519.0
TLS2_k127_2929341_1 Peptidase M56 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 458.0
TLS2_k127_2929632_0 sulfuric ester hydrolase activity - - - 0.0000000000000000000000000000000000000003638 153.0
TLS2_k127_2929632_1 TIR domain - - - 0.000000000000000000000000000004573 130.0
TLS2_k127_2929632_3 Nacht domain - - - 0.000000000000002413 86.0
TLS2_k127_2932791_0 Glycosyl hydrolase family 3 K05349 - 3.2.1.21 5e-324 1008.0
TLS2_k127_2932791_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00895 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.90 1.146e-203 651.0
TLS2_k127_2932791_2 UV-endonuclease UvdE K13281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 455.0
TLS2_k127_2932791_3 single-stranded DNA 5'-3' exodeoxyribonuclease activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 313.0
TLS2_k127_2932791_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000006155 171.0
TLS2_k127_2932791_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000004075 168.0
TLS2_k127_2932791_6 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000003202 111.0
TLS2_k127_2939632_0 Glycosyltransferase like family 2 K10012 - 2.4.2.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 366.0
TLS2_k127_2939632_1 XdhC and CoxI family K07402 - - 0.0000000000000000009883 88.0
TLS2_k127_2939632_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000004297 57.0
TLS2_k127_2940366_0 Glycosyl hydrolase family 9 - - - 6.584e-236 743.0
TLS2_k127_2951243_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 406.0
TLS2_k127_2951243_1 H( )-stimulated, divalent metal cation uptake system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008147 376.0
TLS2_k127_2951243_2 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000001124 209.0
TLS2_k127_2951243_3 - - - - 0.00001756 47.0
TLS2_k127_2952581_0 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000006192 154.0
TLS2_k127_2952581_1 enzyme involved in inositol metabolism K03337 - 5.3.1.30 0.0000000000000000000000000000000008406 141.0
TLS2_k127_2952581_2 Glycogen debranching enzyme - - - 0.000000001364 62.0
TLS2_k127_2952581_3 Concanavalin A-like lectin/glucanases superfamily - - - 0.0002548 53.0
TLS2_k127_2954371_0 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 299.0
TLS2_k127_2954371_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000005152 222.0
TLS2_k127_2954371_2 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000007177 188.0
TLS2_k127_2954371_3 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.00000000000000000000008887 104.0
TLS2_k127_2954371_4 Outer membrane protein (OmpH-like) K06142 - - 0.000000000001272 76.0
TLS2_k127_295744_0 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 327.0
TLS2_k127_295744_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000004182 221.0
TLS2_k127_295744_2 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000000000001855 172.0
TLS2_k127_295744_3 molybdate abc transporter K02018,K15496 - - 0.0000000000000000000000000007182 114.0
TLS2_k127_295744_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000002181 113.0
TLS2_k127_295744_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000004344 103.0
TLS2_k127_295744_6 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.0005927 51.0
TLS2_k127_2968844_0 PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000001853 195.0
TLS2_k127_2968844_1 Beta-L-arabinofuranosidase, GH127 K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000008396 183.0
TLS2_k127_2968844_2 membrane-anchored protein conserved in bacteria - - - 0.0000000592 63.0
TLS2_k127_3017664_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009181 245.0
TLS2_k127_3017664_1 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.000004839 50.0
TLS2_k127_3028963_0 Protein of unknown function (DUF763) K09003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007094 456.0
TLS2_k127_3028963_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000001429 160.0
TLS2_k127_3028963_2 TIGRFAM thioredoxin K03672 - 1.8.1.8 0.000000000000000000000000000000000001497 143.0
TLS2_k127_3028963_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000002511 56.0
TLS2_k127_3033387_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 393.0
TLS2_k127_3033387_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008939 295.0
TLS2_k127_3033387_2 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000007364 242.0
TLS2_k127_3033387_3 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000002704 140.0
TLS2_k127_3045354_0 PFAM D-aminoacylase, C-terminal region K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006184 550.0
TLS2_k127_3045354_1 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005523 338.0
TLS2_k127_3045354_2 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.00000000000000000000000000000000001219 140.0
TLS2_k127_3045354_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000005867 80.0
TLS2_k127_3045828_0 Protein tyrosine kinase K08884 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005895 344.0
TLS2_k127_3046173_0 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000005752 128.0
TLS2_k127_3046173_1 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000001142 121.0
TLS2_k127_3046173_2 Acetyl xylan esterase (AXE1) - - - 0.000000001112 67.0
TLS2_k127_3048552_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.302e-272 848.0
TLS2_k127_3048552_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 394.0
TLS2_k127_3048552_2 cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000001153 251.0
TLS2_k127_3048552_3 Acetyl xylan esterase (AXE1) - - - 0.0000000000000000000000000000000000000000000000000000001667 201.0
TLS2_k127_3048552_4 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000000000000000000000007722 111.0
TLS2_k127_3048552_5 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.0000000000005654 78.0
TLS2_k127_3048552_6 signal sequence binding K07152 - - 0.000000005044 58.0
TLS2_k127_306005_0 aerobic electron transport chain K00425 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 587.0
TLS2_k127_306005_1 oxidative phosphorylation K00426 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 373.0
TLS2_k127_306005_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.00001049 50.0
TLS2_k127_3064827_0 Glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 339.0
TLS2_k127_3064827_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 293.0
TLS2_k127_3064827_2 ADP-glyceromanno-heptose 6-epimerase activity K19997,K22320 - 1.1.1.412,5.1.3.26 0.000000000000000000000000000000000000000000000000000000000000000000003502 245.0
TLS2_k127_3064827_3 group 2 family protein - - - 0.000000000000000000000000000000000000000000000000000001168 200.0
TLS2_k127_3064827_4 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000004044 177.0
TLS2_k127_3070293_0 Alanine racemase, N-terminal domain K18425,K19967 - 4.1.2.42,4.1.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002038 290.0
TLS2_k127_3070293_1 (ABC) transporter K15738,K18231 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005805 281.0
TLS2_k127_3080174_0 Poly A polymerase head domain K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 422.0
TLS2_k127_3080174_1 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000005166 177.0
TLS2_k127_3080174_2 Anaphase-promoting complex, cyclosome, subunit 3 K03350 GO:0000003,GO:0000151,GO:0000152,GO:0000209,GO:0000278,GO:0000375,GO:0000377,GO:0000398,GO:0001775,GO:0003002,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0006139,GO:0006396,GO:0006397,GO:0006464,GO:0006508,GO:0006511,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0007049,GO:0007088,GO:0007091,GO:0007275,GO:0007338,GO:0007343,GO:0007346,GO:0007389,GO:0008150,GO:0008152,GO:0008283,GO:0008356,GO:0008380,GO:0009056,GO:0009057,GO:0009566,GO:0009798,GO:0009948,GO:0009949,GO:0009952,GO:0009987,GO:0010467,GO:0010498,GO:0010564,GO:0010965,GO:0015630,GO:0016070,GO:0016071,GO:0016192,GO:0016567,GO:0016740,GO:0017156,GO:0019538,GO:0019787,GO:0019899,GO:0019902,GO:0019903,GO:0019941,GO:0019953,GO:0022402,GO:0022414,GO:0030163,GO:0031145,GO:0031461,GO:0031974,GO:0031981,GO:0032446,GO:0032501,GO:0032502,GO:0032940,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034641,GO:0036211,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043632,GO:0043900,GO:0043901,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044770,GO:0044772,GO:0044784,GO:0045055,GO:0046483,GO:0046903,GO:0048519,GO:0048856,GO:0050789,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0051603,GO:0051704,GO:0051726,GO:0051783,GO:0051983,GO:0060467,GO:0060468,GO:0060471,GO:0061630,GO:0061659,GO:0065001,GO:0065007,GO:0070013,GO:0070647,GO:0070979,GO:0071704,GO:0080154,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1903047,GO:1905818,GO:1990234,GO:2000241,GO:2000242 - 0.0000000007308 70.0
TLS2_k127_308697_0 Tetratricopeptide repeat - - - 0.0 1427.0
TLS2_k127_308697_1 OmpA family - - - 0.0 1271.0
TLS2_k127_308697_2 Tetratricopeptide repeat - - - 6.728e-303 939.0
TLS2_k127_308697_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001682 240.0
TLS2_k127_308697_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000005219 160.0
TLS2_k127_310288_0 Baseplate J-like protein - - - 1.14e-288 915.0
TLS2_k127_310288_1 Gene 25-like lysozyme K06903 - - 0.000000000000000000000000000000000000000003251 160.0
TLS2_k127_310288_2 - - - - 0.000000000000000000000000000000000006351 139.0
TLS2_k127_310288_3 Phage late control gene D protein (GPD) - - - 0.0000000000000000006021 89.0
TLS2_k127_3104449_0 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000005529 240.0
TLS2_k127_3104449_1 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000002131 179.0
TLS2_k127_3104449_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000004015 153.0
TLS2_k127_3104449_3 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000008624 128.0
TLS2_k127_3104449_4 - - - - 0.00000000000000000000000000008377 120.0
TLS2_k127_3104449_5 Histidine kinase - - - 0.000000000000000000419 103.0
TLS2_k127_3104449_6 GAF domain - - - 0.000000000000005204 89.0
TLS2_k127_3122216_0 - - - - 0.0000000000001015 76.0
TLS2_k127_3122216_1 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.00000000003083 65.0
TLS2_k127_3128962_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit, Bacillus subtilis subgroup K00239 - 1.3.5.1,1.3.5.4 1.193e-289 897.0
TLS2_k127_3128962_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 356.0
TLS2_k127_3128962_2 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 353.0
TLS2_k127_3128962_3 Trehalose utilisation K09992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 316.0
TLS2_k127_3128962_4 Protein of unknown function (DUF3365) - - - 0.00000000000000000000000000007845 123.0
TLS2_k127_3134902_0 Belongs to the BshC family K22136 - - 0.000000000000000000000000000000000000000000000000000102 203.0
TLS2_k127_3134902_1 TIGRFAM competence protein ComEA helix-hairpin-helix K02237 - - 0.00000000000006027 73.0
TLS2_k127_3137777_0 PFAM Transposase IS116 IS110 IS902 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008046 324.0
TLS2_k127_3144950_0 Belongs to the 'phage' integrase family - - - 0.0000000000000000001173 101.0
TLS2_k127_3159816_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000002668 246.0
TLS2_k127_3159816_1 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000001505 167.0
TLS2_k127_3159816_2 D-aminopeptidase K16203 - - 0.00000000000000000000000000000000000000003893 163.0
TLS2_k127_3159816_3 mandelate racemase muconate lactonizing K01684,K08323 - 4.2.1.6,4.2.1.8 0.000000000000000000000000003684 115.0
TLS2_k127_3159816_4 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000003712 118.0
TLS2_k127_3159816_5 FCD - - - 0.00000000000000002521 89.0
TLS2_k127_3160627_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1093.0
TLS2_k127_3160627_1 Transcription termination factor nusG - - - 0.000000001071 61.0
TLS2_k127_3166170_0 Polysaccharide biosynthesis/export protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 324.0
TLS2_k127_3166170_1 AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000004919 218.0
TLS2_k127_3166170_2 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000003153 183.0
TLS2_k127_3166170_3 Forkhead associated domain - - - 0.00000000000000000000000000000000000000000000003149 187.0
TLS2_k127_317157_0 transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006003 391.0
TLS2_k127_317157_1 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003278 244.0
TLS2_k127_3181770_0 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 338.0
TLS2_k127_3181770_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 328.0
TLS2_k127_3181770_2 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 313.0
TLS2_k127_3181770_3 NmrA-like family K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000002211 200.0
TLS2_k127_3181770_4 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000006964 54.0
TLS2_k127_3187904_0 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 303.0
TLS2_k127_3187904_1 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000004925 134.0
TLS2_k127_3187904_2 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000666 126.0
TLS2_k127_3187975_0 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 480.0
TLS2_k127_3187975_1 Male sterility protein K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001301 272.0
TLS2_k127_3191173_0 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007669 469.0
TLS2_k127_3191173_1 Xylose isomerase-like TIM barrel K03079 - 5.1.3.22 0.000000000000000000000000000000000000000000008045 164.0
TLS2_k127_3191173_2 Transporter - - - 0.0000000000000000000000000009785 116.0
TLS2_k127_3191173_3 Universal stress protein - - - 0.0000000000000000000003313 108.0
TLS2_k127_3222834_0 Phosphate acyltransferases K00655,K01897 - 2.3.1.51,6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 569.0
TLS2_k127_3222834_1 COG0657 Esterase lipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001515 286.0
TLS2_k127_3222834_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000392 163.0
TLS2_k127_3226041_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004521 259.0
TLS2_k127_3226041_1 PFAM Polysaccharide pyruvyl transferase - - - 0.000000000000000001854 95.0
TLS2_k127_3241482_0 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 445.0
TLS2_k127_3241482_1 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 390.0
TLS2_k127_3241482_2 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004432 270.0
TLS2_k127_3241482_3 protein-disulfide reductase activity K01999,K08309 - - 0.000000000000002171 87.0
TLS2_k127_3241482_4 ATP-dependent DNA helicase activity K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.0000000007293 61.0
TLS2_k127_3241482_5 protein trimerization - - - 0.0003976 51.0
TLS2_k127_3245525_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 344.0
TLS2_k127_3245525_1 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009998 327.0
TLS2_k127_3245525_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 312.0
TLS2_k127_3245525_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002715 289.0
TLS2_k127_3245525_4 EVE domain - - - 0.000000000000000000000000000000000000000000000001986 178.0
TLS2_k127_3245525_5 Capsular polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000004753 155.0
TLS2_k127_325129_0 Gluconate K03299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 353.0
TLS2_k127_325129_1 Similarity to COG0471 Di- and tricarboxylate transporters(Evalue K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 308.0
TLS2_k127_3255551_0 Protein of unknown function (DUF1565) - - - 4.222e-219 696.0
TLS2_k127_3255551_1 mandelate racemase muconate lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003127 292.0
TLS2_k127_3255551_2 alpha beta - - - 0.00000000000009227 81.0
TLS2_k127_3255551_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000001335 64.0
TLS2_k127_3259289_0 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 492.0
TLS2_k127_3259289_1 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 457.0
TLS2_k127_3259289_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002763 366.0
TLS2_k127_3259289_3 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 320.0
TLS2_k127_3259289_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 319.0
TLS2_k127_3259289_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009555 304.0
TLS2_k127_3259289_6 Domain of unknown function (DUF4432) - - - 0.0000000000000000000000000000000000000000000000000000000000000000004635 235.0
TLS2_k127_3259289_7 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000002811 227.0
TLS2_k127_3269824_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000003871 248.0
TLS2_k127_3269824_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000009258 222.0
TLS2_k127_3269824_2 Hypothetical glycosyl hydrolase 6 - - - 0.00000000000000000000000000000000000000000000000000002055 201.0
TLS2_k127_3270964_0 ABC-type Fe3 transport system permease component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 312.0
TLS2_k127_3270964_1 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000007058 208.0
TLS2_k127_3270964_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000001679 198.0
TLS2_k127_3284324_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 399.0
TLS2_k127_3284324_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000001819 192.0
TLS2_k127_3284324_2 Regulatory protein - - - 0.000000000000000000000002111 108.0
TLS2_k127_3284324_3 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000005324 78.0
TLS2_k127_3284324_4 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000001659 74.0
TLS2_k127_329851_0 COGs COG0673 dehydrogenase and related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006438 401.0
TLS2_k127_329851_1 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 323.0
TLS2_k127_329851_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 323.0
TLS2_k127_329851_3 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002824 277.0
TLS2_k127_329851_4 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003733 250.0
TLS2_k127_329851_5 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000003459 126.0
TLS2_k127_329851_6 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07006 - - 0.000000000000000000009966 100.0
TLS2_k127_329851_7 Glycosyl transferase, family 2 - - - 0.0000000000000000004078 99.0
TLS2_k127_329851_8 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000007294 64.0
TLS2_k127_3305435_0 Aldo/keto reductase family K07079 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 312.0
TLS2_k127_3305435_1 Amidohydrolase - - - 0.00000000000000000000000000000000000000002078 169.0
TLS2_k127_3311267_0 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 571.0
TLS2_k127_3311267_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007645 274.0
TLS2_k127_3311267_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000001665 167.0
TLS2_k127_3311267_3 - - - - 0.0000000000000000003696 92.0
TLS2_k127_3328185_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649,K02594 - 2.3.3.13,2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 367.0
TLS2_k127_3328185_1 SIS domain K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000009066 205.0
TLS2_k127_3328185_2 pfam rok K00845 - 2.7.1.2 0.0000000000000000000000000000000000000005837 162.0
TLS2_k127_3328185_3 Major facilitator superfamily - - - 0.00000000000741 74.0
TLS2_k127_3348449_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 2.163e-276 863.0
TLS2_k127_3348449_1 Belongs to the glycosyl hydrolase 57 family - - - 6.006e-240 761.0
TLS2_k127_3348741_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004341 458.0
TLS2_k127_3348741_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 389.0
TLS2_k127_3348741_2 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 338.0
TLS2_k127_3348741_3 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000001088 269.0
TLS2_k127_3348741_4 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000002347 184.0
TLS2_k127_3348741_5 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000008555 126.0
TLS2_k127_3348741_6 Hfq protein - - - 0.00000000000000000000000000009019 117.0
TLS2_k127_3348741_7 integral membrane protein - - - 0.00000000000000000000002317 107.0
TLS2_k127_3348741_8 Type IV pilus biogenesis stability protein PilW - - - 0.00000008932 59.0
TLS2_k127_3348741_9 Adenosine monophosphate-protein transferase FICD homolog - GO:0000166,GO:0003008,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006950,GO:0006952,GO:0007600,GO:0007601,GO:0007610,GO:0007632,GO:0008081,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009584,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009966,GO:0009987,GO:0010646,GO:0012505,GO:0015696,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0017076,GO:0018117,GO:0018175,GO:0019538,GO:0023051,GO:0030176,GO:0030544,GO:0030554,GO:0031072,GO:0031224,GO:0031227,GO:0031967,GO:0031975,GO:0031984,GO:0032501,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034260,GO:0034976,GO:0035639,GO:0036094,GO:0036211,GO:0042175,GO:0042578,GO:0042742,GO:0042802,GO:0042803,GO:0043086,GO:0043087,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044601,GO:0044602,GO:0044603,GO:0045117,GO:0046983,GO:0048519,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050829,GO:0050877,GO:0050896,GO:0050906,GO:0050908,GO:0050953,GO:0050962,GO:0051087,GO:0051179,GO:0051234,GO:0051336,GO:0051346,GO:0051606,GO:0051608,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0065009,GO:0070566,GO:0070733,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0080134,GO:0080135,GO:0097159,GO:0097367,GO:0098542,GO:0098827,GO:0140096,GO:1900101,GO:1901265,GO:1901363,GO:1901564,GO:1903894,GO:1905897 - 0.000007165 57.0
TLS2_k127_334890_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 1.013e-199 637.0
TLS2_k127_334890_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 486.0
TLS2_k127_334890_10 - - - - 0.000000002863 65.0
TLS2_k127_334890_11 - - - - 0.0000001812 54.0
TLS2_k127_334890_12 PFAM SMP-30 Gluconolaconase K01053 - 3.1.1.17 0.0000007992 62.0
TLS2_k127_334890_2 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 331.0
TLS2_k127_334890_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 310.0
TLS2_k127_334890_4 Band 7 protein K07192 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001012 244.0
TLS2_k127_334890_5 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000009024 239.0
TLS2_k127_334890_6 Protein of unknown function (DUF3592) - - - 0.000000000000000000000000000000009105 138.0
TLS2_k127_334890_7 DNA-binding transcription factor activity K03892 - - 0.000000000000000000000000000001313 124.0
TLS2_k127_334890_8 COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription K03969 - - 0.00000000000000001348 92.0
TLS2_k127_334890_9 AI-2E family transporter - - - 0.0000000000000002022 88.0
TLS2_k127_3355173_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0 1244.0
TLS2_k127_3355173_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1217.0
TLS2_k127_3362057_0 response to abiotic stimulus K03086,K06867 - - 1.757e-198 628.0
TLS2_k127_3362057_1 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002908 250.0
TLS2_k127_3362057_2 Glycosyl hydrolases family 35 - - - 0.000000000000000000000000000000000000000000000000000000000000000003985 233.0
TLS2_k127_3362057_3 Transposase IS200 like - - - 0.0000000000000000000000000000000000000000000000000000001194 204.0
TLS2_k127_336731_0 polysaccharide export K01991 - - 2.185e-221 698.0
TLS2_k127_3367645_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 576.0
TLS2_k127_3367645_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 325.0
TLS2_k127_3367645_2 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily K00145,K05829 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000002373 268.0
TLS2_k127_3367645_3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring - - - 0.0000000000000000000000000000000000000000000000000000001711 208.0
TLS2_k127_3367645_4 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000004424 166.0
TLS2_k127_3367645_5 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000002778 106.0
TLS2_k127_3367645_6 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000001815 71.0
TLS2_k127_3372238_0 Pyridine nucleotide-disulphide oxidoreductase - - - 9.166e-209 664.0
TLS2_k127_3372238_1 Coenzyme F420-reducing hydrogenase, gamma subunit K14128 - 1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 343.0
TLS2_k127_3372238_2 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000003194 202.0
TLS2_k127_3372238_3 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.000000000000000000000000000000000000001497 151.0
TLS2_k127_3372238_4 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000005083 132.0
TLS2_k127_3373803_0 Proton-conducting membrane transporter K12141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 520.0
TLS2_k127_3373803_1 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 524.0
TLS2_k127_3373803_2 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006189 308.0
TLS2_k127_3373803_3 Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001258 289.0
TLS2_k127_3373803_4 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000003189 190.0
TLS2_k127_3383545_0 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family K02100,K03444,K08138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 591.0
TLS2_k127_3383545_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 405.0
TLS2_k127_3383545_2 BNR repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006502 261.0
TLS2_k127_3383545_3 PFAM glycoside hydrolase, family 9 K01179 - 3.2.1.4 0.0000000000000000000000000009846 126.0
TLS2_k127_3383931_0 PFAM Trehalose utilisation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 476.0
TLS2_k127_3383931_1 xyloglucan:xyloglucosyl transferase activity - - - 0.000000000000000000000000000000000000000000001145 175.0
TLS2_k127_3383931_2 PEGA domain - - - 0.0000000000000000000000000000005628 128.0
TLS2_k127_3383931_3 PIN domain - - - 0.0000000000000002287 80.0
TLS2_k127_338418_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 422.0
TLS2_k127_338418_1 TIGRFAM TIGR00268 family protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009441 275.0
TLS2_k127_338418_2 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000004714 246.0
TLS2_k127_338418_3 Lumazine binding domain K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000004656 181.0
TLS2_k127_338418_4 Belongs to the pseudouridine synthase RsuA family K06178,K06182 - 5.4.99.21,5.4.99.22 0.000000000000000003072 87.0
TLS2_k127_3385579_0 Trimethylamine methyltransferase K14083 - 2.1.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 355.0
TLS2_k127_3385579_1 TIGRFAM methyltransferase cognate corrinoid proteins, Methanosarcina family - - - 0.0000000000000000000000000000000000000000000000000000003601 202.0
TLS2_k127_3385579_2 Hydantoinaseoxoprolinase domain protein - - - 0.000000000000000000000337 101.0
TLS2_k127_339114_0 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 6.161e-293 921.0
TLS2_k127_339114_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002323 267.0
TLS2_k127_339114_3 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000001327 106.0
TLS2_k127_339114_4 BON domain - - - 0.00008447 54.0
TLS2_k127_3398542_0 PFAM Response regulator receiver domain K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 515.0
TLS2_k127_3398542_1 Formiminotransferase domain, N-terminal subdomain K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 292.0
TLS2_k127_3398542_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000001492 238.0
TLS2_k127_3398542_3 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - 0.000000000000000000000000000000000000000000000000000000005939 209.0
TLS2_k127_3398542_4 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000001453 174.0
TLS2_k127_3399518_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 320.0
TLS2_k127_3399518_1 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000001141 255.0
TLS2_k127_3399518_2 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000001702 202.0
TLS2_k127_3399518_3 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000001677 128.0
TLS2_k127_3408430_0 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006335 396.0
TLS2_k127_3408430_1 PFAM oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002367 256.0
TLS2_k127_3408430_2 ROK family - - - 0.000000000000000000000000000000000000000000000000002175 202.0
TLS2_k127_3408430_3 Carbohydrate family 9 binding domain-like - - - 0.0000000000000000000000000006682 120.0
TLS2_k127_341280_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1100.0
TLS2_k127_341280_1 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 333.0
TLS2_k127_341280_2 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 315.0
TLS2_k127_341280_3 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001151 267.0
TLS2_k127_341280_4 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000000000000000000000000000000000000000000000000004414 257.0
TLS2_k127_341280_5 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000002469 241.0
TLS2_k127_341280_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000001091 219.0
TLS2_k127_341280_7 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000001549 164.0
TLS2_k127_341280_8 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000005904 147.0
TLS2_k127_341280_9 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.00000000000000000000000000002665 119.0
TLS2_k127_3420316_0 serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 4.058e-276 855.0
TLS2_k127_3420316_1 Belongs to the DapA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 492.0
TLS2_k127_3420316_10 PFAM TrkA-N domain K03499 - - 0.0007364 48.0
TLS2_k127_3420316_2 Sodium/hydrogen exchanger family K11105 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009695 494.0
TLS2_k127_3420316_3 transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 366.0
TLS2_k127_3420316_4 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 329.0
TLS2_k127_3420316_5 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000009093 235.0
TLS2_k127_3420316_6 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000148 196.0
TLS2_k127_3420316_7 Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000000000000000000000000000003712 183.0
TLS2_k127_3420316_8 Ferric uptake regulator family K09825 - - 0.0000000000000000000000000000000000000000000000007397 183.0
TLS2_k127_3420316_9 DinB family - - - 0.0001409 46.0
TLS2_k127_3430792_0 ATPase BadF BadG BcrA BcrD type - - - 1.855e-301 955.0
TLS2_k127_3430792_1 glucuronate isomerase K01812 - 5.3.1.12 1.309e-195 619.0
TLS2_k127_3430792_2 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000008182 120.0
TLS2_k127_3435529_0 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000182 269.0
TLS2_k127_3435529_1 Zinc carboxypeptidase K01278 - 3.4.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000004602 255.0
TLS2_k127_3435529_2 response to stress - - - 0.00000001154 66.0
TLS2_k127_3476979_0 ASPIC and UnbV - - - 1.151e-264 824.0
TLS2_k127_3477973_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008105 457.0
TLS2_k127_3477973_1 Belongs to the CinA family K03742 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 326.0
TLS2_k127_3477973_2 Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000133 285.0
TLS2_k127_3477973_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.000000000000000000000000000000000007446 143.0
TLS2_k127_3477973_4 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.000000000000000000000000007323 123.0
TLS2_k127_3477973_5 phosphatidylglycerophosphatase activity K01095 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 0.0000000000000000000000002895 113.0
TLS2_k127_3477973_6 Trm112p-like protein K00912,K09791 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.1.130 0.00000000000000000001075 94.0
TLS2_k127_3477973_7 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372 - 0.000000000002877 68.0
TLS2_k127_3477973_8 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000177 59.0
TLS2_k127_3477973_9 Domain of unknown function (DUF4129) - - - 0.00006586 51.0
TLS2_k127_3489567_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 308.0
TLS2_k127_3494786_0 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 446.0
TLS2_k127_3494786_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000002812 217.0
TLS2_k127_3494786_2 tryptophan synthase K01694,K06001 - 4.2.1.20 0.0000000000000000000000000000000002769 133.0
TLS2_k127_3494786_3 - - - - 0.00000000002078 75.0
TLS2_k127_3505480_0 lysine biosynthetic process via aminoadipic acid - - - 1.165e-207 673.0
TLS2_k127_3505480_1 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007301 248.0
TLS2_k127_3509235_0 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000001081 233.0
TLS2_k127_3509235_1 transferase activity, transferring glycosyl groups K07011,K13659 - 2.4.1.264 0.000000000000000000000000000000000000201 156.0
TLS2_k127_3509776_0 Domain of unknown function (DUF362) - - - 0.00000000000000000001707 106.0
TLS2_k127_3509776_2 - - - - 0.00000004235 62.0
TLS2_k127_3510630_0 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 426.0
TLS2_k127_3510630_1 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009982 398.0
TLS2_k127_3510630_2 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.00000000000000000000000002377 111.0
TLS2_k127_3510630_3 Lipid A biosynthesis K02517 - 2.3.1.241 0.00000000001258 76.0
TLS2_k127_3515720_0 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007716 462.0
TLS2_k127_3515720_1 (ABC) transporter K15738,K18231 - - 0.00000000000000000000000000000000000000000000000000000000000000000001765 239.0
TLS2_k127_3515720_2 DinB family - - - 0.000000000000000000000000000000000000000000000000000000000000012 221.0
TLS2_k127_3515720_3 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000004779 131.0
TLS2_k127_352114_0 PA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 489.0
TLS2_k127_352114_1 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 391.0
TLS2_k127_352114_2 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000001015 206.0
TLS2_k127_352114_3 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000004268 194.0
TLS2_k127_3527025_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 453.0
TLS2_k127_3527025_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000003542 243.0
TLS2_k127_3527025_2 Biotin/lipoate A/B protein ligase family K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.0000000000000000000000000000002156 133.0
TLS2_k127_3527025_3 Belongs to the aldehyde dehydrogenase family K22187 - - 0.0000000000000000000004261 95.0
TLS2_k127_3528797_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 581.0
TLS2_k127_3528797_1 PFAM NAD-dependent epimerase dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 493.0
TLS2_k127_3528797_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000002732 168.0
TLS2_k127_3528797_3 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000916 150.0
TLS2_k127_3539390_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370,K07306,K17050 - 1.7.5.1,1.8.5.3 0.0 1384.0
TLS2_k127_3539390_1 nitrate reductase beta subunit K00371,K17051 - 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 537.0
TLS2_k127_3539390_2 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 421.0
TLS2_k127_3539390_3 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000027 213.0
TLS2_k127_3539390_4 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.0000000000000000000000000004094 125.0
TLS2_k127_3539390_5 COG3278 Cbb3-type cytochrome oxidase, subunit 1 - - - 0.0000000000000000000000005166 108.0
TLS2_k127_3539390_6 protein complex oligomerization - - - 0.0004264 51.0
TLS2_k127_3543065_0 Glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1784.0
TLS2_k127_3543065_1 COG0583 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005207 271.0
TLS2_k127_3544440_0 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 294.0
TLS2_k127_3544440_1 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000001263 228.0
TLS2_k127_3544440_2 von Willebrand factor, type A - - - 0.000000000000000000000000000000001058 149.0
TLS2_k127_3550944_0 - - - - 0.0000000000000000000000000000001778 136.0
TLS2_k127_3550944_1 nucleotidyltransferase activity K07061 - - 0.0000000000000000000000000004471 118.0
TLS2_k127_3550944_2 SBF-like CPA transporter family (DUF4137) K03453,K14347 - - 0.0000001691 52.0
TLS2_k127_3550944_3 Protein of unknown function (DUF2442) - - - 0.0005123 43.0
TLS2_k127_3554283_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 0.0 1151.0
TLS2_k127_3554283_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 8.898e-208 657.0
TLS2_k127_3554283_2 PASTA K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000000000000000000000000004711 136.0
TLS2_k127_3559811_0 PFAM glycoside hydrolase, family 29 K01206 - 3.2.1.51 1.237e-201 636.0
TLS2_k127_3559811_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 329.0
TLS2_k127_3559811_2 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000409 244.0
TLS2_k127_3559811_3 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000001762 171.0
TLS2_k127_3560203_0 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 423.0
TLS2_k127_3560203_1 Alpha amylase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 427.0
TLS2_k127_3560203_2 BON domain - - - 0.0002068 51.0
TLS2_k127_3567009_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 1.137e-301 960.0
TLS2_k127_3567009_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 2.674e-196 652.0
TLS2_k127_3567009_2 PFAM PfkB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 397.0
TLS2_k127_3567009_3 Ion transport protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002436 251.0
TLS2_k127_3567009_4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000012 195.0
TLS2_k127_3567009_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000001468 138.0
TLS2_k127_3567009_6 Tetratricopeptide repeat - - - 0.0000000000000000000006189 110.0
TLS2_k127_3568711_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000001149 207.0
TLS2_k127_3568711_1 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000000000000001725 181.0
TLS2_k127_3579984_0 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 483.0
TLS2_k127_3585150_0 Carboxypeptidase regulatory-like domain - - - 3.457e-310 985.0
TLS2_k127_3585150_1 Tetratricopeptide repeat - - - 0.00000005235 63.0
TLS2_k127_3590209_0 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000001279 171.0
TLS2_k127_3590209_1 MFS/sugar transport protein - - - 0.0000000000000000000000000000000000000004119 165.0
TLS2_k127_3590209_2 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000002088 151.0
TLS2_k127_3590209_3 Flavin reductase like domain - - - 0.00000000000000000000000000006576 122.0
TLS2_k127_3614321_0 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 325.0
TLS2_k127_3614321_1 PFAM peptidase K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000005968 170.0
TLS2_k127_3614321_2 cobalamin binding K22491 - - 0.0000000000000001118 91.0
TLS2_k127_3626349_0 ECF sigma factor K03088 - - 0.00000000000000000000000000004295 123.0
TLS2_k127_3626349_1 Smr domain - - - 0.000000000000000000000000001513 122.0
TLS2_k127_3626349_2 - - - - 0.000000003173 66.0
TLS2_k127_3626349_3 Putative zinc-finger - - - 0.000000005518 64.0
TLS2_k127_3630065_0 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 319.0
TLS2_k127_3630065_1 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000137 288.0
TLS2_k127_3630065_2 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000003526 181.0
TLS2_k127_3630065_3 Glycosyl transferase, family 2 - - - 0.000000000000000004642 96.0
TLS2_k127_3634511_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000193 275.0
TLS2_k127_3634511_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000001699 223.0
TLS2_k127_3634511_2 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000004645 218.0
TLS2_k127_3635800_0 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000003238 191.0
TLS2_k127_3635800_1 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000000216 166.0
TLS2_k127_3635800_2 Cytidylate kinase-like family K00760 - 2.4.2.8 0.00000000000000000000000000000000001222 141.0
TLS2_k127_365599_0 Carbamoyltransferase C-terminus K00612 - - 5.976e-256 800.0
TLS2_k127_365599_1 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 474.0
TLS2_k127_365599_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 360.0
TLS2_k127_365599_3 Glycosyl transferase, family 2 K00721,K07011,K12990,K14597,K21349 - 2.4.1.268,2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 351.0
TLS2_k127_365599_4 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005183 269.0
TLS2_k127_365599_5 Ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000347 241.0
TLS2_k127_365599_6 Protein of unknown function (DUF421) - - - 0.0000000000000000000000000000000000000000000000000000000005139 213.0
TLS2_k127_365599_7 MFS_1 like family - - - 0.000000000000000000000000000000000000000000003233 175.0
TLS2_k127_36578_0 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000002569 272.0
TLS2_k127_36578_1 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006661 266.0
TLS2_k127_36578_2 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000002049 248.0
TLS2_k127_36578_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000245 247.0
TLS2_k127_36578_4 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001436 239.0
TLS2_k127_36578_5 DinB family - - - 0.0000000000000000000000000000000000816 140.0
TLS2_k127_36578_6 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.000000000000000000000000000000005095 143.0
TLS2_k127_36578_7 AntiSigma factor - - - 0.00000000000000000000000000001289 126.0
TLS2_k127_36578_8 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000229 68.0
TLS2_k127_3665014_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.073e-278 868.0
TLS2_k127_3665014_1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005817 306.0
TLS2_k127_3665014_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000009667 231.0
TLS2_k127_3665014_3 TIGRFAM lipopolysaccharide heptosyltransferase II K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000001338 232.0
TLS2_k127_3665014_4 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000003561 218.0
TLS2_k127_3665014_5 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000001455 222.0
TLS2_k127_3699945_0 carbohydrate binding - - - 3.829e-240 755.0
TLS2_k127_3699945_1 pfkB family carbohydrate kinase - - - 6.322e-204 640.0
TLS2_k127_3699945_2 Kinase, PfkB family K00874 - 2.7.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007784 525.0
TLS2_k127_3699945_3 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005846 487.0
TLS2_k127_3699945_4 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000002793 160.0
TLS2_k127_3703465_0 Radical_SAM C-terminal domain K07139 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 325.0
TLS2_k127_3703465_1 Cytochrome oxidase assembly protein K02259,K03110 - - 0.0000000000000000000000000000000000000615 152.0
TLS2_k127_3703465_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01091,K06019 - 3.1.3.18,3.6.1.1 0.000000000000000000000000000505 123.0
TLS2_k127_3703465_3 Putative adhesin - - - 0.0000000000000009493 91.0
TLS2_k127_3703465_4 N-terminal domain of toast_rack, DUF2154 - - - 0.00000000003794 73.0
TLS2_k127_3703465_5 Phosphorylase superfamily K01243 - 3.2.2.9 0.00000000783 64.0
TLS2_k127_3705144_0 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002005 260.0
TLS2_k127_3705144_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000002251 224.0
TLS2_k127_3705144_2 Belongs to the universal ribosomal protein uS5 family K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000001817 214.0
TLS2_k127_3705144_3 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000000000173 200.0
TLS2_k127_3705144_4 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000005895 191.0
TLS2_k127_3705144_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000001208 153.0
TLS2_k127_3705144_6 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000005326 149.0
TLS2_k127_3705144_7 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000007073 101.0
TLS2_k127_3705144_8 Ribosomal protein L30 K02907 - - 0.0000000000003496 72.0
TLS2_k127_3711190_0 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 494.0
TLS2_k127_3711190_1 Phosphodiester glycosidase - - - 0.000000000000000000000000000000000000000000000003393 188.0
TLS2_k127_3714456_0 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 435.0
TLS2_k127_3714456_1 positive regulation of macromolecule biosynthetic process K03973 - - 0.000000000002051 69.0
TLS2_k127_3714456_2 TIGRFAM TonB family protein K03832 - - 0.0005754 52.0
TLS2_k127_3743935_0 Arsenical pump membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 318.0
TLS2_k127_3743935_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000007604 246.0
TLS2_k127_3744207_0 general secretion pathway protein G K02456 - - 0.0000000000000000000000000000000000000000000000001179 181.0
TLS2_k127_3744207_1 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000000001183 182.0
TLS2_k127_3744207_2 Type II secretion system (T2SS), protein F K02455,K02653 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - 0.0000000000000000000000000000000000000000000008493 169.0
TLS2_k127_3744207_3 Prokaryotic N-terminal methylation motif K02459 - - 0.000000001654 68.0
TLS2_k127_3744207_4 fimbrial assembly K02461 - - 0.00000001857 63.0
TLS2_k127_3744207_5 Prokaryotic N-terminal methylation motif K02458 - - 0.00000009651 59.0
TLS2_k127_3744207_6 general secretion pathway protein K02457 - - 0.000955 49.0
TLS2_k127_3749225_0 membrane organization K07277,K09800 - - 0.0 1063.0
TLS2_k127_3750417_0 phospholipase Carboxylesterase - - - 0.0000000000000000000000000006215 132.0
TLS2_k127_3750417_2 Membrane-bound dehydrogenase domain - - - 0.000001328 62.0
TLS2_k127_3751630_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008701 412.0
TLS2_k127_3751630_1 Homoserine dehydrogenase, NAD binding domain K00003 GO:0003674,GO:0003824,GO:0004412,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002804 280.0
TLS2_k127_3751630_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000003246 229.0
TLS2_k127_3755773_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 597.0
TLS2_k127_3755773_1 acyl-CoA dehydrogenase activity K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 336.0
TLS2_k127_3755773_2 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000002053 201.0
TLS2_k127_3762130_0 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 327.0
TLS2_k127_3762130_1 PFAM DinB family - - - 0.0000000000000000000000000000000000000000000008596 172.0
TLS2_k127_3762130_2 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000006716 163.0
TLS2_k127_3762130_3 - - - - 0.00000000000000000000000000000006632 138.0
TLS2_k127_3762130_4 protease with the C-terminal PDZ domain - - - 0.00000000000000001615 96.0
TLS2_k127_3762130_5 - - - - 0.0000000002982 69.0
TLS2_k127_3762130_6 general secretion pathway protein - - - 0.00000002525 55.0
TLS2_k127_3762820_0 belongs to the aldehyde dehydrogenase family K04021,K13922 GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007082 593.0
TLS2_k127_3762820_1 Class II Aldolase and Adducin N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 411.0
TLS2_k127_3762820_10 Ethanolamine utilisation protein EutN/carboxysome - - - 0.000000000000005511 79.0
TLS2_k127_3762820_2 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003785 359.0
TLS2_k127_3762820_3 propanediol catabolic process K15024 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000002558 228.0
TLS2_k127_3762820_4 ethanolamine catabolic process K04027 - - 0.0000000000000000000000000000000009118 132.0
TLS2_k127_3762820_5 ethanolamine catabolic process K04027 - - 0.0000000000000000000000000000001604 125.0
TLS2_k127_3762820_6 Carbon dioxide concentrating mechanism carboxysome shell protein K04027 - - 0.0000000000000000000000000000002948 125.0
TLS2_k127_3762820_7 carbohydrate kinase FGGY K00848 - 2.7.1.5 0.0000000000000000000000003454 106.0
TLS2_k127_3762820_8 PFAM Ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.0000000000000000000002384 100.0
TLS2_k127_3762820_9 PFAM Ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.000000000000000006258 87.0
TLS2_k127_3763286_0 Belongs to the glycosyl hydrolase 2 family K01190 - 3.2.1.23 2.21e-260 826.0
TLS2_k127_3763286_1 Cleaves the N-terminal amino acid of tripeptides K01258 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 441.0
TLS2_k127_3763286_2 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007496 245.0
TLS2_k127_3763286_3 BNR repeat-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005474 227.0
TLS2_k127_3763286_4 - - - - 0.00000000000000000000000000000000032 135.0
TLS2_k127_3772686_0 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 540.0
TLS2_k127_3772686_1 UPF0365 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 503.0
TLS2_k127_3772686_2 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 457.0
TLS2_k127_3772686_3 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000002207 227.0
TLS2_k127_3772686_4 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000003902 176.0
TLS2_k127_3772686_5 PFAM Polysaccharide deacetylase - - - 0.00000000000000000003989 93.0
TLS2_k127_3772686_6 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000005895 58.0
TLS2_k127_3778160_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004694 378.0
TLS2_k127_3778160_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 372.0
TLS2_k127_3778160_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004421 344.0
TLS2_k127_3778160_3 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008839 316.0
TLS2_k127_378885_0 Beta galactosidase small chain K01190 - 3.2.1.23 6.82e-290 920.0
TLS2_k127_378885_1 L-fucose isomerase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 468.0
TLS2_k127_378885_2 Parallel beta-helix repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 426.0
TLS2_k127_378885_3 metallopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 344.0
TLS2_k127_378885_4 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005664 310.0
TLS2_k127_378885_5 - - - - 0.00000000000001264 80.0
TLS2_k127_3803501_0 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 296.0
TLS2_k127_3803501_1 PFAM oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006464 253.0
TLS2_k127_3803501_2 - - - - 0.000000000000002346 91.0
TLS2_k127_3807660_0 phosphorelay sensor kinase activity - - - 0.00000000000000000000000000000000000000000000000005665 190.0
TLS2_k127_3807660_1 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000001046 121.0
TLS2_k127_381013_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 4.928e-315 984.0
TLS2_k127_381013_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009833 301.0
TLS2_k127_381013_2 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000448 256.0
TLS2_k127_381013_3 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004827 246.0
TLS2_k127_381013_4 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000004455 225.0
TLS2_k127_381013_5 bacterial (prokaryotic) histone like domain K03530 - - 0.000000000000000000000000000000003206 130.0
TLS2_k127_3810219_0 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid K03328,K16694,K16695 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000001274 178.0
TLS2_k127_3810219_1 Glycosyl transferase - - - 0.00000000000000000000000000000000004085 149.0
TLS2_k127_3810219_2 O-Antigen ligase - - - 0.0000002862 63.0
TLS2_k127_381534_0 TonB-dependent receptor - - - 1.197e-201 654.0
TLS2_k127_381534_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004166 622.0
TLS2_k127_381534_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 494.0
TLS2_k127_381534_3 Tetratricopeptide repeat - - - 0.000000000001613 80.0
TLS2_k127_381534_4 - - - - 0.00000000004976 74.0
TLS2_k127_3826330_0 Glycosyl-hydrolase 97 C-terminal, oligomerisation K01187 - 3.2.1.20 0.0000000000000000000000000000000000000003173 157.0
TLS2_k127_3826330_1 AAA-like domain - - - 0.0000000000000001124 88.0
TLS2_k127_3826330_2 transport - - - 0.0000000000000001521 85.0
TLS2_k127_3827156_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.17,6.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006973 489.0
TLS2_k127_3827156_1 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 379.0
TLS2_k127_3827156_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000002268 224.0
TLS2_k127_3827156_3 Two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.0000000000000000000000000000000000000000000000000001276 193.0
TLS2_k127_3827156_4 Phytol kinase K15892,K18678 - 2.7.1.182,2.7.1.216 0.00000000001366 74.0
TLS2_k127_3827156_5 Carboxypeptidase regulatory-like domain - - - 0.0001268 53.0
TLS2_k127_3832426_0 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006166 536.0
TLS2_k127_3844265_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 513.0
TLS2_k127_3844265_1 InterPro IPR007367 - - - 0.0000000002351 61.0
TLS2_k127_3844265_2 Protein of unknown function (DUF433) - - - 0.0001938 48.0
TLS2_k127_3847455_0 Galactose mutarotase-like K01811 - 3.2.1.177 4.826e-209 656.0
TLS2_k127_3847455_1 PFAM TonB-dependent Receptor Plug Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 522.0
TLS2_k127_3854628_0 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 331.0
TLS2_k127_3854628_1 dehydrogenases and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000356 252.0
TLS2_k127_3860211_0 Protein of unknown function DUF262 - - - 0.0000000000000000000000000000000000000000009597 169.0
TLS2_k127_3860211_1 Region found in RelA / SpoT proteins - - - 0.0000000000000000000000000002312 127.0
TLS2_k127_3860211_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000001734 65.0
TLS2_k127_3860211_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000489 46.0
TLS2_k127_3861890_0 Signal transducing histidine kinase, homodimeric domain K03407,K13490 - 2.7.13.3 6.224e-217 703.0
TLS2_k127_3861890_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 479.0
TLS2_k127_3861890_2 SMART chemotaxis sensory transducer K03406,K13487 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 381.0
TLS2_k127_3861890_3 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412,K13491 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 344.0
TLS2_k127_3861890_4 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001509 276.0
TLS2_k127_3861890_5 Methyltransferase, chemotaxis proteins K13486 - - 0.00000000000000000000000000000000000000000000000000000000000000000001611 249.0
TLS2_k127_3861890_6 Two component signalling adaptor domain K13489 - - 0.00000000000000000000000000000000000000000001742 171.0
TLS2_k127_3861890_7 Chemotaxis signal transduction protein K13488 - - 0.0000000000000000000000000000000004544 140.0
TLS2_k127_3861890_8 STAS domain - - - 0.00000000000000000000004889 104.0
TLS2_k127_3882646_0 hydrolase, family 65, central catalytic K15923 - 3.2.1.51 2.151e-240 765.0
TLS2_k127_3882646_1 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 406.0
TLS2_k127_3882646_2 aminopeptidase activity - - - 0.000000000000000000000000000002224 131.0
TLS2_k127_3882646_3 amine dehydrogenase activity - - - 0.0000000000000000000000000001331 121.0
TLS2_k127_3884747_0 UPF0489 domain - - - 0.00000000000000000000000000000000000000000118 169.0
TLS2_k127_3884747_1 tRNA processing - - - 0.000000000000000000000000000000000000004529 159.0
TLS2_k127_3884747_2 - - - - 0.000000000007603 71.0
TLS2_k127_3884747_3 Acetyltransferase (GNAT) family - - - 0.0000000003618 68.0
TLS2_k127_3884747_4 TIGRFAM TOMM propeptide domain - - - 0.0000008227 55.0
TLS2_k127_3892890_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 7.484e-248 776.0
TLS2_k127_3892890_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001088 260.0
TLS2_k127_3893416_0 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 580.0
TLS2_k127_3893416_1 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 426.0
TLS2_k127_3893416_2 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000003157 195.0
TLS2_k127_3895905_0 Rhodanese Homology Domain K01069 - 3.1.2.6 4.866e-195 621.0
TLS2_k127_3895905_1 Glycosyl hydrolase family 26 K01218 - 3.2.1.78 0.0000000000000000000000000000000000000001653 153.0
TLS2_k127_3895905_2 PFAM YeeE YedE family (DUF395) K07112 - - 0.000000000000000000000000000000000000000306 151.0
TLS2_k127_3895905_3 Galactose oxidase, central domain - - - 0.000000000000000000000000000000000000005615 157.0
TLS2_k127_3898764_0 PFAM Prolyl oligopeptidase family - - - 2.694e-286 891.0
TLS2_k127_3898764_1 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 346.0
TLS2_k127_3898764_2 IgA Peptidase M64 - - - 0.00000000000000000192 90.0
TLS2_k127_3899996_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0 2086.0
TLS2_k127_3899996_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 512.0
TLS2_k127_3899996_2 ketosteroid isomerase - - - 0.000000000000000000000000001578 118.0
TLS2_k127_3901257_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 3.041e-212 672.0
TLS2_k127_3901257_1 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003274 284.0
TLS2_k127_3901257_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000002035 252.0
TLS2_k127_3901257_3 Protein of unknown function (DUF503) K09764 - - 0.00000000000001068 78.0
TLS2_k127_3905581_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1507.0
TLS2_k127_3905581_1 ABC transporter transmembrane K18890 - - 1.193e-283 882.0
TLS2_k127_3905581_2 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 493.0
TLS2_k127_3905581_3 PFAM Peptidase S41 K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 488.0
TLS2_k127_3905581_4 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000168 288.0
TLS2_k127_3923484_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005702 278.0
TLS2_k127_3923484_1 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000002643 188.0
TLS2_k127_3923484_2 denitrification pathway - GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0019645,GO:0022900,GO:0022904,GO:0044237,GO:0045333,GO:0055114 - 0.00000000000000000001393 102.0
TLS2_k127_3938500_0 PFAM Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 523.0
TLS2_k127_3938500_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778 - 1.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 439.0
TLS2_k127_3938500_2 - - - - 0.0000000000000000000000000000000000000005352 151.0
TLS2_k127_3938500_3 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.0000000000000000000000000003105 117.0
TLS2_k127_3939879_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 1.811e-260 816.0
TLS2_k127_3939879_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 553.0
TLS2_k127_3939879_2 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 386.0
TLS2_k127_3939879_3 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 346.0
TLS2_k127_3939879_4 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000006138 191.0
TLS2_k127_3939879_5 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K07025 - - 0.00000000000000000000000000000000000000000000008264 177.0
TLS2_k127_3939879_6 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000001033 168.0
TLS2_k127_3950359_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000000000000000000000000000000000000000001003 208.0
TLS2_k127_3952811_0 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003231 459.0
TLS2_k127_3952811_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002932 441.0
TLS2_k127_3952811_2 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 422.0
TLS2_k127_3952811_3 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002668 269.0
TLS2_k127_3956191_0 - - - - 0.000000000000000000000000000000000000001866 156.0
TLS2_k127_3956191_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000007705 56.0
TLS2_k127_3958945_0 Glutamine amidotransferases class-II K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 547.0
TLS2_k127_3958945_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008086 457.0
TLS2_k127_3958945_2 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 285.0
TLS2_k127_3958945_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000002261 190.0
TLS2_k127_4005737_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.303e-194 621.0
TLS2_k127_4005737_1 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 525.0
TLS2_k127_4005737_2 PFAM ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 399.0
TLS2_k127_4005737_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 389.0
TLS2_k127_4005737_4 UPF0056 membrane protein - - - 0.0000000000000000000000000000000000000000000000002134 182.0
TLS2_k127_4005737_6 - - - - 0.000000002781 68.0
TLS2_k127_4008006_0 Methyl-accepting chemotaxis protein (MCP) signaling domain K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000617 364.0
TLS2_k127_4008006_1 SMART chemotaxis sensory transducer K03406,K13487 - - 0.0000000000000000000000000000000000933 141.0
TLS2_k127_4008006_2 transporter antisigma-factor antagonist STAS K04749,K06378 - - 0.0000000000000000000000000005645 118.0
TLS2_k127_4008006_3 Histidine kinase-like ATPase domain - - - 0.00000000000000000000000003265 117.0
TLS2_k127_4008006_4 Belongs to the glycosyl hydrolase 43 family - - - 0.0000000005121 64.0
TLS2_k127_401161_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 308.0
TLS2_k127_401161_1 PFAM imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000001088 218.0
TLS2_k127_401161_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009314,GO:0009411,GO:0009416,GO:0009507,GO:0009532,GO:0009536,GO:0009555,GO:0009570,GO:0009628,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0032501,GO:0032502,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046483,GO:0048229,GO:0048856,GO:0050896,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000004477 160.0
TLS2_k127_401161_3 glutamine metabolic process K02501 GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - 0.000000000000000000000000000000003092 132.0
TLS2_k127_4031780_0 PFAM FxsA cytoplasmic membrane protein K07113 - - 0.00000000000000000008584 91.0
TLS2_k127_4031798_0 Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 611.0
TLS2_k127_4031798_1 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 331.0
TLS2_k127_4031798_2 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.0000000000007549 70.0
TLS2_k127_4031798_3 ECF sigma factor - - - 0.0003157 46.0
TLS2_k127_4033629_0 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 423.0
TLS2_k127_4033629_1 Ribonuclease, BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 297.0
TLS2_k127_4033629_2 translation release factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000009879 229.0
TLS2_k127_4033629_3 Histidine kinase K13040 - 2.7.13.3 0.00000000000000000000000000000000000000000000000005164 190.0
TLS2_k127_4033629_4 HAD-hyrolase-like - - - 0.0000000000000000000000000000000000000000002273 166.0
TLS2_k127_4033629_5 PFAM Periplasmic binding protein LacI transcriptional regulator K10439,K17202 - - 0.00000000000000000000000000000003981 137.0
TLS2_k127_4033785_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335,K03469 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7,3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005555 487.0
TLS2_k127_4033785_1 ECF sigma factor K03088 - - 0.00000000000000000000000000000000009132 141.0
TLS2_k127_4041839_0 Bacterial membrane protein YfhO - - - 0.00000000000000000000231 109.0
TLS2_k127_4044574_0 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 469.0
TLS2_k127_4044574_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000002458 223.0
TLS2_k127_4044574_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000004293 160.0
TLS2_k127_4044574_3 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.0000000000000000000000008489 109.0
TLS2_k127_404694_0 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001661 281.0
TLS2_k127_404694_1 COG0438 Glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001661 260.0
TLS2_k127_404694_2 Predicted integral membrane protein (DUF2270) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002037 242.0
TLS2_k127_404694_3 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000007944 138.0
TLS2_k127_404694_4 PFAM thioesterase superfamily K07107 - - 0.0000000000000000000000000000005833 127.0
TLS2_k127_404694_5 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) K02517 - 2.3.1.241 0.00000000000000005141 86.0
TLS2_k127_4052072_0 UTP--glucose-1-phosphate uridylyltransferase - - - 5.776e-215 677.0
TLS2_k127_4052072_1 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 352.0
TLS2_k127_4052072_2 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000001234 185.0
TLS2_k127_4052072_3 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000005807 167.0
TLS2_k127_4052072_4 PspA/IM30 family K03969 - - 0.0000000000007631 78.0
TLS2_k127_4052072_5 ATPases associated with a variety of cellular activities K02049 - - 0.0000000002832 65.0
TLS2_k127_4052414_0 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 512.0
TLS2_k127_4052414_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 477.0
TLS2_k127_4052414_2 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007588 412.0
TLS2_k127_4054334_0 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 4.016e-201 647.0
TLS2_k127_4054334_1 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009084 611.0
TLS2_k127_4054334_10 ATP synthase I chain - - - 0.0003415 46.0
TLS2_k127_4054334_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008194 521.0
TLS2_k127_4054334_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 364.0
TLS2_k127_4054334_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 357.0
TLS2_k127_4054334_5 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000005347 188.0
TLS2_k127_4054334_6 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000000000000000001977 158.0
TLS2_k127_4054334_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000005529 139.0
TLS2_k127_4054334_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00332 - 1.6.5.3 0.0000000000002927 70.0
TLS2_k127_4054334_9 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.00000001864 59.0
TLS2_k127_4055868_0 COG0553 Superfamily II DNA RNA - - - 6.437e-269 846.0
TLS2_k127_4055868_1 Belongs to the serpin family K13963 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 333.0
TLS2_k127_4055868_2 SWIM zinc finger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006314 283.0
TLS2_k127_40722_0 Uncharacterized conserved protein (DUF2294) - - - 0.00000000000000000000000000000000000000000000000000000000001225 210.0
TLS2_k127_40722_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000181 201.0
TLS2_k127_40722_2 Uncharacterized conserved protein (DUF2294) - - - 0.0000000000000000000000000000000000000000000000007166 178.0
TLS2_k127_40722_3 Histidine kinase - - - 0.0000000000000000000000000009907 120.0
TLS2_k127_40722_4 - - - - 0.0000000000001919 74.0
TLS2_k127_40722_5 Protein of unknown function (DUF1328) - - - 0.0000006982 56.0
TLS2_k127_4074446_0 Domain of unknown function (DUF4185) - - - 0.000000000000000000000000000000000000000000000000000000000000003682 225.0
TLS2_k127_4074446_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000006698 186.0
TLS2_k127_4074446_2 - - - - 0.0000000000000000000000000000000000000000000006868 173.0
TLS2_k127_4082711_0 Pfam Ion transport protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 344.0
TLS2_k127_4082711_1 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 318.0
TLS2_k127_4082711_2 Peptidase S46 - - - 0.00000000000000000000000000000000000000000000002811 171.0
TLS2_k127_4082711_3 granule-associated protein - - - 0.000000000002212 71.0
TLS2_k127_4085354_0 B12 binding domain K00548 - 2.1.1.13 0.0 1044.0
TLS2_k127_4085354_1 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000646 104.0
TLS2_k127_4091063_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 368.0
TLS2_k127_4091063_1 methylamine metabolic process K15977 - - 0.00000000000000000000000000000000000000000008081 163.0
TLS2_k127_4091063_2 glycoside hydrolase - - - 0.00000000000000000000000000000000009561 153.0
TLS2_k127_4091063_3 IMG reference gene - - - 0.00000000000000000000000005551 120.0
TLS2_k127_4100335_0 Alpha-2-Macroglobulin K06894 - - 2.086e-313 981.0
TLS2_k127_4100335_1 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 574.0
TLS2_k127_4107204_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4.035e-218 686.0
TLS2_k127_4107204_1 TIGRFAM methylmalonyl-CoA mutase C-terminal domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000006068 192.0
TLS2_k127_4107204_2 nucleotide metabolic process - - - 0.0000000000000000000000000000000000002762 152.0
TLS2_k127_4107204_3 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000278 108.0
TLS2_k127_412587_0 PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001574 289.0
TLS2_k127_412587_1 - - - - 0.000000000000000000000000002957 117.0
TLS2_k127_412587_2 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives K02343 - 2.7.7.7 0.000000000000000001785 97.0
TLS2_k127_414381_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 582.0
TLS2_k127_414381_1 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 308.0
TLS2_k127_414381_2 Secretin and TonB N terminus short domain K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005927 274.0
TLS2_k127_414381_3 COG0006 Xaa-Pro aminopeptidase K01262,K01271 - 3.4.11.9,3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000002655 240.0
TLS2_k127_414381_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788,K14153 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000002386 154.0
TLS2_k127_414381_5 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000001181 135.0
TLS2_k127_414381_6 Pilus assembly protein, PilO K02664 - - 0.000000000000000000001104 104.0
TLS2_k127_414381_7 PFAM Fimbrial assembly family protein K02663 - - 0.00000003003 63.0
TLS2_k127_4144544_0 transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008074 518.0
TLS2_k127_4144544_1 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000006349 146.0
TLS2_k127_4144544_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000004163 103.0
TLS2_k127_4144544_3 - - - - 0.000000004388 64.0
TLS2_k127_4147716_0 membrane organization K07277,K09800 - - 3.987e-288 928.0
TLS2_k127_4151192_0 PFAM nickel-dependent hydrogenase, large subunit K14126 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 426.0
TLS2_k127_4151192_1 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 426.0
TLS2_k127_4151192_2 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 404.0
TLS2_k127_4151192_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001639 269.0
TLS2_k127_4151192_4 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000008595 216.0
TLS2_k127_4151192_5 Histidine kinase K07675,K09684 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000285 208.0
TLS2_k127_4151192_6 COG2202 FOG PAS PAC domain - - - 0.00000000000000000000000000004107 132.0
TLS2_k127_4154885_0 Natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 483.0
TLS2_k127_4154885_1 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 353.0
TLS2_k127_4154885_2 Belongs to the UPF0271 (lamB) family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004934 300.0
TLS2_k127_4154885_3 Allophanate hydrolase subunit 1 K06351 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006303 273.0
TLS2_k127_4154885_4 Allophanate hydrolase subunit 2 K06350 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002463 260.0
TLS2_k127_4154885_5 lipopolysaccharide N-acetylmannosaminouronosyltransferase activity - - - 0.0000000000000000000000000000000000000001539 160.0
TLS2_k127_4154885_6 - - - - 0.0005122 52.0
TLS2_k127_4169760_0 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000000000008793 157.0
TLS2_k127_4169760_1 Protein of unknown function DUF86 - - - 0.00000000000000000000000000000000763 130.0
TLS2_k127_4169760_2 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000000000000000017 111.0
TLS2_k127_4169760_3 Manganese containing catalase - - - 0.00000000000000000000492 93.0
TLS2_k127_4169760_4 Sulfatase - - - 0.0001958 47.0
TLS2_k127_4173855_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009941 417.0
TLS2_k127_4173855_1 SMART alpha amylase catalytic sub domain K01187 - 3.2.1.20 0.000000000000000000000000000000000000000000000000000001256 193.0
TLS2_k127_4185097_0 Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) K00849 - 2.7.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 361.0
TLS2_k127_4185097_1 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000004888 143.0
TLS2_k127_4185097_2 Iron-sulfur cluster-binding domain K06139 - - 0.00000000001016 68.0
TLS2_k127_4196986_0 Alpha-L-fucosidase K01206 - 3.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 402.0
TLS2_k127_4196986_1 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000000000004182 102.0
TLS2_k127_4196986_2 CHAP domain - - - 0.0000000000001643 76.0
TLS2_k127_4200145_0 beta-galactosidase activity K01190,K01219,K12308 - 3.2.1.23,3.2.1.81 1.372e-242 768.0
TLS2_k127_4200145_1 Domain of unknown function (DUF5060) - - - 6.291e-222 699.0
TLS2_k127_4200145_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005022 299.0
TLS2_k127_4200145_3 DinB family - - - 0.00000007044 56.0
TLS2_k127_4200686_0 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006153 404.0
TLS2_k127_4200686_1 PFAM Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000008494 184.0
TLS2_k127_4200686_2 - - - - 0.0000000000000000000416 97.0
TLS2_k127_4200686_3 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000007147 93.0
TLS2_k127_42081_0 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 381.0
TLS2_k127_42081_1 Polysaccharide export protein K01991,K20988 - - 0.0000000000000000000000000000000000000000000000006217 190.0
TLS2_k127_42081_2 PFAM Phosphoribosyltransferase K02242 - - 0.00000000000000000000000000000000005056 143.0
TLS2_k127_42081_3 COG3307 Lipid A core - O-antigen ligase and related enzymes K18814 - - 0.000000000000000000000000000003454 135.0
TLS2_k127_42081_4 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000001003 118.0
TLS2_k127_42081_5 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000002959 110.0
TLS2_k127_42081_6 SMART Tetratricopeptide - - - 0.00003723 56.0
TLS2_k127_4212040_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 392.0
TLS2_k127_4212040_1 PFAM Carbamoyltransferase K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 389.0
TLS2_k127_4212040_2 hydroxypyruvate isomerase activity K01816,K22131 - 5.3.1.22,5.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002162 285.0
TLS2_k127_4212040_3 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000971 207.0
TLS2_k127_4212040_4 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000006738 153.0
TLS2_k127_4212040_5 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000003718 87.0
TLS2_k127_4212040_6 - - - - 0.000005866 54.0
TLS2_k127_4225797_0 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008271 520.0
TLS2_k127_4225797_1 PFAM sigma-54 factor interaction domain-containing protein K02481,K07714,K10943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 367.0
TLS2_k127_4225797_2 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 286.0
TLS2_k127_4225797_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000006594 110.0
TLS2_k127_4234671_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000002889 215.0
TLS2_k127_4234671_1 Radical SAM - - - 0.0000000002904 67.0
TLS2_k127_4238061_0 quinone binding K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 356.0
TLS2_k127_4238061_1 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000003076 226.0
TLS2_k127_4238061_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000004438 169.0
TLS2_k127_4238061_3 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336,K05299 - 1.17.1.10,1.6.5.3 0.000000000000000003324 87.0
TLS2_k127_4238061_4 von Willebrand factor, type A - - - 0.00000000002112 71.0
TLS2_k127_4243125_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 437.0
TLS2_k127_4243125_1 lipoprotein localization to outer membrane K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 302.0
TLS2_k127_4243125_2 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000001401 239.0
TLS2_k127_4243125_3 Peptidase family M28 - - - 0.0003809 48.0
TLS2_k127_4243538_0 Alpha-L-fucosidase K01206 - 3.2.1.51 0.00000000000000000000000000000000000000000000000000000000002232 211.0
TLS2_k127_4243538_1 - - - - 0.0000000008398 70.0
TLS2_k127_4246910_0 Protein of unknown function (DUF2961) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 538.0
TLS2_k127_4246910_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 547.0
TLS2_k127_4246910_2 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 327.0
TLS2_k127_4246910_3 transport - - - 0.0000000000000000002774 104.0
TLS2_k127_4250494_0 - - - - 0.0000000000000000000000000000000000000000000000001299 200.0
TLS2_k127_4264143_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 471.0
TLS2_k127_4264143_1 Putative adhesin - - - 0.000000000000000001224 98.0
TLS2_k127_4264143_2 HEAT repeats - - - 0.000000000000000001269 94.0
TLS2_k127_4267268_0 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000007059 215.0
TLS2_k127_4267268_1 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00001686 57.0
TLS2_k127_4269488_0 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 335.0
TLS2_k127_4272116_0 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 359.0
TLS2_k127_4272116_1 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 346.0
TLS2_k127_4272116_2 Maltose acetyltransferase K00661 - 2.3.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 289.0
TLS2_k127_4272116_3 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000231 273.0
TLS2_k127_4272116_4 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000004233 136.0
TLS2_k127_4274660_0 isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004073 274.0
TLS2_k127_4274660_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000001278 211.0
TLS2_k127_4274660_2 SnoaL-like polyketide cyclase - - - 0.00000001594 62.0
TLS2_k127_4274660_3 Serine Threonine protein kinase K12132 - 2.7.11.1 0.000006163 58.0
TLS2_k127_4276743_0 PFAM glycosyl transferase group 1 K12995 - 2.4.1.348 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 371.0
TLS2_k127_4276743_1 transferase activity, transferring glycosyl groups K12994 - 2.4.1.349 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 349.0
TLS2_k127_4276743_2 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000004667 183.0
TLS2_k127_4276743_3 Putative regulatory protein - - - 0.0000000000000000000000000008393 117.0
TLS2_k127_4276743_4 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000001726 124.0
TLS2_k127_4276748_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 385.0
TLS2_k127_4276748_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 330.0
TLS2_k127_4276748_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000003095 154.0
TLS2_k127_4276748_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000001643 129.0
TLS2_k127_4276748_4 plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000002905 120.0
TLS2_k127_4276748_5 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000003698 73.0
TLS2_k127_4276748_6 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000005769 48.0
TLS2_k127_4291223_0 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 3.631e-301 946.0
TLS2_k127_4291223_1 aconitate hydratase K01681 - 4.2.1.3 0.000000000000000000000000000000000000000000000000000000000003441 211.0
TLS2_k127_4291223_2 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000000001918 177.0
TLS2_k127_4294956_0 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007417 421.0
TLS2_k127_4294956_1 3-demethylubiquinone-9 3-O-methyltransferase activity K00568,K20444 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000132 148.0
TLS2_k127_4295357_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 4.252e-212 681.0
TLS2_k127_4295357_1 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 511.0
TLS2_k127_4295357_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000007823 233.0
TLS2_k127_4295357_3 Belongs to the UPF0502 family K09915 - - 0.000000000000000000000000000000000000000000000000000000000004869 214.0
TLS2_k127_4295357_4 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000001018 199.0
TLS2_k127_429763_0 PFAM Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 316.0
TLS2_k127_429763_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000003631 223.0
TLS2_k127_429763_2 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.000000000000000000000001855 104.0
TLS2_k127_429763_3 polysaccharide biosynthetic process K06409 - - 0.00000007236 65.0
TLS2_k127_429763_4 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.000000231 63.0
TLS2_k127_4302709_0 Creatinase/Prolidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 352.0
TLS2_k127_4302709_1 - - - - 0.000000000000000003538 98.0
TLS2_k127_4302709_2 - - - - 0.000000003532 70.0
TLS2_k127_4309_0 Cytochrome c K00425 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 551.0
TLS2_k127_4309_1 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009716 309.0
TLS2_k127_4309_2 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 290.0
TLS2_k127_4309_3 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000000000000009168 205.0
TLS2_k127_4312600_0 Belongs to the RuBisCO large chain family K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 454.0
TLS2_k127_4312600_1 Putative nucleotide-binding of sugar-metabolising enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 388.0
TLS2_k127_4312600_2 - - - - 0.000000000000000000000000000000000000000000000001352 180.0
TLS2_k127_4312600_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000005424 84.0
TLS2_k127_4315560_0 pyrroloquinoline quinone binding K12349 - 3.5.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 567.0
TLS2_k127_4315560_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000289 117.0
TLS2_k127_4315560_2 Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000004679 83.0
TLS2_k127_4315560_3 cAMP biosynthetic process K01768,K02483 - 4.6.1.1 0.0000000000001162 81.0
TLS2_k127_4315560_4 Transcriptional regulatory protein, C terminal - - - 0.000000000001504 68.0
TLS2_k127_4315560_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.000005418 57.0
TLS2_k127_4315560_7 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00002656 46.0
TLS2_k127_4316493_0 response regulator K10943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 426.0
TLS2_k127_4316493_1 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 346.0
TLS2_k127_4316493_2 Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium K07709 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.0000000000000000000000000000000003639 139.0
TLS2_k127_4316493_3 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000007329 129.0
TLS2_k127_4319649_0 C-terminal, D2-small domain, of ClpB protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 580.0
TLS2_k127_4319649_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001663 274.0
TLS2_k127_4319649_2 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000007981 198.0
TLS2_k127_4324348_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 6.578e-245 786.0
TLS2_k127_4324348_1 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000003192 196.0
TLS2_k127_4324348_2 His Kinase A (phosphoacceptor) domain K07709 - 2.7.13.3 0.00006486 53.0
TLS2_k127_4333878_0 Berberine and berberine like - - - 2.632e-205 647.0
TLS2_k127_4333878_1 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000005395 167.0
TLS2_k127_4333878_2 - - - - 0.0000000000000000000001198 99.0
TLS2_k127_4333878_3 The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system K02526 - - 0.0000000000002022 72.0
TLS2_k127_433819_0 COGs COG4299 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 487.0
TLS2_k127_433819_1 phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002488 256.0
TLS2_k127_433819_2 Photosystem reaction center subunit H - - - 0.00000000002955 71.0
TLS2_k127_4344327_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 406.0
TLS2_k127_4344327_1 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000832 192.0
TLS2_k127_4344327_2 PFAM Uncharacterised protein family UPF0079, ATPase K06925 - - 0.00000000000000000000000009743 111.0
TLS2_k127_4366033_0 belongs to the aldehyde dehydrogenase family K00135,K08324 GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 559.0
TLS2_k127_4366033_1 ATPase activity K02045 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 452.0
TLS2_k127_4366033_2 FCD - - - 0.0000000000000000000003893 100.0
TLS2_k127_4366033_3 Tetratricopeptide repeat - - - 0.00000000000000000007995 99.0
TLS2_k127_4376800_0 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 392.0
TLS2_k127_4376800_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 395.0
TLS2_k127_4376800_2 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 386.0
TLS2_k127_4376800_3 PFAM sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 306.0
TLS2_k127_4376800_4 Glycosyl transferase, family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000001648 228.0
TLS2_k127_4387483_0 cell adhesion involved in biofilm formation K13735,K20276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 451.0
TLS2_k127_4392637_0 Pfam:Methyltransf_6 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 311.0
TLS2_k127_4392637_1 HEAT repeats - - - 0.00000000000000000007564 96.0
TLS2_k127_4392637_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000001177 62.0
TLS2_k127_4395995_0 metallopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 405.0
TLS2_k127_4395995_1 protocatechuate 3,4-dioxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 298.0
TLS2_k127_4395995_2 PFAM Formylglycine-generating sulfatase enzyme K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000002162 219.0
TLS2_k127_4395995_3 - - - - 0.0000000000000000000000000000000000000000003336 178.0
TLS2_k127_4395995_4 oxidoreductase activity, acting on diphenols and related substances as donors K02636 - 1.10.9.1 0.0000000000000000000000004148 112.0
TLS2_k127_4417872_0 Beta-galactosidase trimerisation domain K12308 - 3.2.1.23 5.386e-203 655.0
TLS2_k127_4417872_1 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 559.0
TLS2_k127_4417872_2 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000107 241.0
TLS2_k127_4417872_3 Roadblock/LC7 domain - - - 0.00000000000003687 78.0
TLS2_k127_4417872_4 peptidyl-tyrosine sulfation - - - 0.000368 49.0
TLS2_k127_4418764_0 Neutral/alkaline non-lysosomal ceramidase, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 379.0
TLS2_k127_4418764_1 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006395 371.0
TLS2_k127_4418764_2 COGs COG0160 4-aminobutyrate aminotransferase and related aminotransferase K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 339.0
TLS2_k127_4418764_3 Belongs to the FGGY kinase family K00851 - 2.7.1.12 0.0000000000000000000000000000001822 132.0
TLS2_k127_4418764_4 PFAM Bacterial regulatory proteins, deoR family K02081,K03436 - - 0.000000000000000000000000000001825 130.0
TLS2_k127_4418764_5 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000006546 95.0
TLS2_k127_4422810_0 Peptidase family C25 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 461.0
TLS2_k127_4422810_1 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000002601 205.0
TLS2_k127_4426850_0 glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 400.0
TLS2_k127_4426850_1 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K16950 - - 0.0000000000000000000000000000001059 131.0
TLS2_k127_4432952_0 BNR repeat-like domain - - - 0.000000000000000000000000000000007824 143.0
TLS2_k127_4432952_1 Belongs to the glycosyl hydrolase 32 family - - - 0.0000000000000000006792 97.0
TLS2_k127_4455799_0 Sodium:dicarboxylate symporter family K03309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 381.0
TLS2_k127_4455799_1 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000017 226.0
TLS2_k127_4455799_2 - - - - 0.000000000000000000001424 104.0
TLS2_k127_4455799_3 Histidine kinase - - - 0.00009764 46.0
TLS2_k127_4456092_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 3.426e-291 901.0
TLS2_k127_4456092_1 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000712 481.0
TLS2_k127_4456092_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000000000000002977 112.0
TLS2_k127_445728_0 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007299 459.0
TLS2_k127_445728_1 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000004254 199.0
TLS2_k127_4463752_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 574.0
TLS2_k127_4463752_1 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007055 543.0
TLS2_k127_4463752_2 glycosyl transferase group 1 K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 428.0
TLS2_k127_4463752_3 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 422.0
TLS2_k127_4463752_4 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009245 419.0
TLS2_k127_4463752_5 ABC-type uncharacterized transport system K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 369.0
TLS2_k127_4463752_6 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 342.0
TLS2_k127_4463752_7 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003219 276.0
TLS2_k127_4463752_8 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000002236 213.0
TLS2_k127_4463752_9 Domain of unknown function (DUF4340) - - - 0.000000000009335 77.0
TLS2_k127_4477549_0 Carboxypeptidase regulatory-like domain - - - 1.522e-271 853.0
TLS2_k127_4484291_0 Domain of unknown function (DUF5060) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 544.0
TLS2_k127_4484291_1 NIPSNAP family containing protein - - - 0.0000000000000007121 82.0
TLS2_k127_4485445_0 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 507.0
TLS2_k127_4485445_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 381.0
TLS2_k127_4485445_2 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007163 323.0
TLS2_k127_4485445_3 CoA binding domain - - - 0.00000000000000001636 88.0
TLS2_k127_448881_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000001838 232.0
TLS2_k127_4490028_0 Protein involved in outer membrane biogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008382 391.0
TLS2_k127_4490028_1 cellulose binding - - - 0.000000000006145 67.0
TLS2_k127_4500652_0 PFAM Alcohol dehydrogenase GroES domain protein K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 314.0
TLS2_k127_4500652_1 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009299 325.0
TLS2_k127_4502861_0 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003997 286.0
TLS2_k127_4502861_1 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000004455 116.0
TLS2_k127_4502861_2 PIN domain - - - 0.00000000000000000000000002201 112.0
TLS2_k127_4502861_3 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000002488 66.0
TLS2_k127_4505788_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 602.0
TLS2_k127_4505788_1 Alpha-L-fucosidase K01206 - 3.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 507.0
TLS2_k127_4505788_2 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 428.0
TLS2_k127_4505788_3 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000001029 146.0
TLS2_k127_4505788_4 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.00007475 49.0
TLS2_k127_4506214_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 619.0
TLS2_k127_4506214_1 Asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 372.0
TLS2_k127_4506214_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 288.0
TLS2_k127_4506214_3 Beta-lactamase class C and other penicillin binding - - - 0.00000000000000000000000000000000000000000000000000000000002989 219.0
TLS2_k127_4506214_4 phosphorelay sensor kinase activity K02478,K07704 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.00000000000000000000000000000000000000000000000000008485 209.0
TLS2_k127_4506214_5 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000007856 166.0
TLS2_k127_4506214_6 AAA domain - - - 0.00000000000000000000000000000000001131 138.0
TLS2_k127_4506214_7 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000002308 63.0
TLS2_k127_4506214_8 Belongs to the peptidase S41A family K03797,K11749 - 3.4.21.102 0.000001139 57.0
TLS2_k127_4506214_9 Psort location Cytoplasmic, score 8.96 - - - 0.0006584 46.0
TLS2_k127_45093_0 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 518.0
TLS2_k127_45093_1 Beta-galactosidase - - - 0.00000000000000000000000000000000000000000000000000000006617 207.0
TLS2_k127_45093_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000001346 126.0
TLS2_k127_451675_0 Catalyzes the synthesis of activated sulfate K00958 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009839 369.0
TLS2_k127_451675_1 AraC-like ligand binding domain - - - 0.000000000000006922 82.0
TLS2_k127_451675_2 Transcriptional regulator - - - 0.000000001609 68.0
TLS2_k127_4517142_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 385.0
TLS2_k127_4517142_1 protein catabolic process K03420,K13525,K17681 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004916 380.0
TLS2_k127_4517142_2 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 297.0
TLS2_k127_4517142_3 COG3678 P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein K06006 - - 0.0000008717 57.0
TLS2_k127_4525817_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 416.0
TLS2_k127_4525817_1 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 395.0
TLS2_k127_4525817_2 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000001535 183.0
TLS2_k127_4525817_3 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000000007262 85.0
TLS2_k127_4525817_4 Protein of unknown function (DUF2892) - - - 0.00001213 51.0
TLS2_k127_4528035_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 615.0
TLS2_k127_4528035_1 PFAM NAD-dependent epimerase dehydratase K08678 - 4.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 488.0
TLS2_k127_4528035_2 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784,K12448 - 5.1.3.2,5.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 367.0
TLS2_k127_4528035_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000004386 244.0
TLS2_k127_4528035_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 0.0000000000000000000000000000000000001048 145.0
TLS2_k127_4528035_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000009225 92.0
TLS2_k127_4540705_0 Alpha-mannosidase K01191,K15524 - 3.2.1.170,3.2.1.24 1.824e-288 898.0
TLS2_k127_4540705_1 symporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003216 262.0
TLS2_k127_4549083_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 358.0
TLS2_k127_4549083_1 WYL domain K13573 - - 0.00000000000000000000000000000000000000000000369 177.0
TLS2_k127_4549083_2 WYL domain K13572 - - 0.0000000000000000000000001846 112.0
TLS2_k127_4549083_3 PAP2 superfamily - - - 0.0000000000000001068 89.0
TLS2_k127_4549083_4 PFAM PEGA domain - - - 0.000007319 55.0
TLS2_k127_4561993_0 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 291.0
TLS2_k127_4561993_1 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000001689 224.0
TLS2_k127_4561993_2 hyperosmotic response - - - 0.0000003069 60.0
TLS2_k127_4561993_3 proteolysis - - - 0.000008339 52.0
TLS2_k127_4561993_4 membrane protein domain - - - 0.00002137 56.0
TLS2_k127_4568951_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 419.0
TLS2_k127_4568951_1 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008001 311.0
TLS2_k127_4568951_2 Fumarylacetoacetate (FAA) hydrolase K01826 - 5.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000003884 263.0
TLS2_k127_4568951_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000005496 239.0
TLS2_k127_4568951_4 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000000000000000000000000000000000325 137.0
TLS2_k127_4568951_5 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769 - 5.2.1.8 0.000000000000000000000000000003067 133.0
TLS2_k127_4568951_6 peptidyl-prolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000001421 118.0
TLS2_k127_4568951_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117,K03646 - - 0.0000000000000005877 80.0
TLS2_k127_4568951_8 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000005591 57.0
TLS2_k127_4578464_0 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007132 609.0
TLS2_k127_4578464_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000001271 114.0
TLS2_k127_457931_0 Belongs to the IlvD Edd family K22396 - 4.2.1.82 4.398e-286 892.0
TLS2_k127_457931_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 5.306e-222 706.0
TLS2_k127_457931_10 - - - - 0.0000000000000000000000000000000000000000000000003996 181.0
TLS2_k127_457931_11 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000007559 134.0
TLS2_k127_457931_12 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000001003 80.0
TLS2_k127_457931_13 PFAM fumarylacetoacetate (FAA) hydrolase K14259 - 4.2.1.141 0.00000000000007745 74.0
TLS2_k127_457931_14 PHP domain protein - - - 0.000000000005803 77.0
TLS2_k127_457931_2 PFAM Gluconate transporter K03299 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 519.0
TLS2_k127_457931_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 481.0
TLS2_k127_457931_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007066 367.0
TLS2_k127_457931_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 374.0
TLS2_k127_457931_6 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009604 353.0
TLS2_k127_457931_7 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003983 293.0
TLS2_k127_457931_8 Ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000007438 241.0
TLS2_k127_457931_9 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000003282 192.0
TLS2_k127_4601033_0 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 556.0
TLS2_k127_4601033_1 Erythromycin esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 541.0
TLS2_k127_4601033_2 PFAM Aminotransferase class I and II K05825 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 483.0
TLS2_k127_4601033_3 Permease family K06901 GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006863,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015205,GO:0015207,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015851,GO:0015853,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904823 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 481.0
TLS2_k127_4601033_4 PFAM sodium calcium exchanger membrane region K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 392.0
TLS2_k127_460459_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 412.0
TLS2_k127_460459_1 Peptidase M64 N-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009343 387.0
TLS2_k127_460459_2 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000008597 156.0
TLS2_k127_460459_3 peroxiredoxin activity - - - 0.0000000000000000000000000000000005267 138.0
TLS2_k127_4606528_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.917e-321 1007.0
TLS2_k127_4606528_1 Belongs to the UPF0235 family K09131 - - 0.0000003704 53.0
TLS2_k127_4616037_0 converts alpha-aldose to the beta-anomer - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001176 286.0
TLS2_k127_4616037_1 Bacterial regulatory proteins, lacI family K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000003726 244.0
TLS2_k127_4616037_2 Periplasmic binding protein-like domain K10439 - - 0.0000000000000000000000000000000000000158 156.0
TLS2_k127_4619664_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 606.0
TLS2_k127_4619664_1 iron-nicotianamine transmembrane transporter activity - GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 370.0
TLS2_k127_4630990_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 539.0
TLS2_k127_4630990_1 TIGRFAM metallophosphoesterase, MG_246 BB_0505 family K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 313.0
TLS2_k127_4630990_2 phenylalanyl-tRNA synthetase (beta subunit) K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 0.00000000000000000000000000000000000000000000006042 180.0
TLS2_k127_4630990_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000003137 101.0
TLS2_k127_4630990_4 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000001318 77.0
TLS2_k127_4639124_0 Putative exonuclease SbcCD, C subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 427.0
TLS2_k127_4639124_1 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 299.0
TLS2_k127_4643070_0 ABC-type sugar transport system periplasmic component K03406,K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 309.0
TLS2_k127_4643070_1 - - - - 0.0002844 47.0
TLS2_k127_4649396_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1546.0
TLS2_k127_4649396_1 Carboxypeptidase regulatory-like domain - - - 0.00000007717 57.0
TLS2_k127_4656814_0 transport - - - 0.00000000000000000000000000000000000000000000000000000000003248 222.0
TLS2_k127_4656814_1 Involved in the tonB-independent uptake of proteins K03641 - - 0.00000000000000000004697 104.0
TLS2_k127_4657111_0 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 557.0
TLS2_k127_4667589_0 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 533.0
TLS2_k127_4667589_1 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 518.0
TLS2_k127_4667589_2 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 509.0
TLS2_k127_4667589_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 442.0
TLS2_k127_4667589_4 FtsX-like permease family - - - 0.0000000000000000000182 98.0
TLS2_k127_4670144_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 6.63e-304 944.0
TLS2_k127_4670144_1 symporter activity K03307 - - 4.352e-291 904.0
TLS2_k127_4670144_10 Allophanate hydrolase subunit 2 K06350 - - 0.00000004705 55.0
TLS2_k127_4670144_2 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 - 1.2.7.11,1.2.7.3 7.797e-248 778.0
TLS2_k127_4670144_3 MgtE intracellular N domain K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 601.0
TLS2_k127_4670144_4 PFAM Glucose Sorbosone dehydrogenase K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 519.0
TLS2_k127_4670144_5 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 434.0
TLS2_k127_4670144_6 Dienelactone hydrolase family K06999 - - 0.0000000000000000000000000000000000000000000000000000000000002411 222.0
TLS2_k127_4670144_7 PFAM Peptidase M23 - - - 0.000000000000000000000000000000000000000000000000003834 192.0
TLS2_k127_468239_0 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 468.0
TLS2_k127_468239_1 NAD(P)H quinone oxidoreductase, PIG3 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 324.0
TLS2_k127_468239_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000002675 156.0
TLS2_k127_468239_3 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000002343 106.0
TLS2_k127_468239_4 Methyltransferase domain - - - 0.000000000000000000352 96.0
TLS2_k127_468239_5 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.0000000000114 72.0
TLS2_k127_468239_6 - - - - 0.00000000007054 75.0
TLS2_k127_4684202_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007382 580.0
TLS2_k127_4684202_2 Protein of unknown function (DUF3347) - - - 0.0000000000004035 77.0
TLS2_k127_4699988_0 Sodium:sulfate symporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006671 490.0
TLS2_k127_4699988_1 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000002722 169.0
TLS2_k127_470821_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 336.0
TLS2_k127_470821_1 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000006641 219.0
TLS2_k127_470821_2 beta-fructofuranosidase activity - - - 0.0000000000000000000000000000000007221 146.0
TLS2_k127_4714795_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003928 441.0
TLS2_k127_4714795_1 Glycosyl hydrolase family 20, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 357.0
TLS2_k127_4714795_2 Acetohydroxy acid isomeroreductase, catalytic domain K00053 - 1.1.1.86 0.000000000000000000000000000000000004897 138.0
TLS2_k127_4714795_3 Hypothetical glycosyl hydrolase 6 - - - 0.000000000000000000001028 98.0
TLS2_k127_4715446_0 - - - - 1.178e-221 701.0
TLS2_k127_4715446_1 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 571.0
TLS2_k127_4715446_2 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003339 268.0
TLS2_k127_4715446_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000002453 145.0
TLS2_k127_4716473_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000006438 206.0
TLS2_k127_4716473_1 phosphorelay sensor kinase activity K02478,K07704 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.000000000000000000000000000000000000000000000000000007315 212.0
TLS2_k127_4716473_2 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000008109 176.0
TLS2_k127_4716473_3 Outer membrane lipoprotein-sorting protein - - - 0.000000000000000000000000000000000000000000009935 170.0
TLS2_k127_4716473_4 OsmC-like protein K06889,K07397 - - 0.0000000000000000000000000000008207 126.0
TLS2_k127_4716473_5 Response regulator of the LytR AlgR family K02477,K08083 - - 0.00000000000000000000000000008468 129.0
TLS2_k127_4716473_6 - - - - 0.00000000000000000000000002669 122.0
TLS2_k127_4716473_7 Tetratricopeptide repeat - - - 0.0008148 52.0
TLS2_k127_4719911_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 530.0
TLS2_k127_4719911_1 Trehalose utilisation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 421.0
TLS2_k127_4719911_3 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 395.0
TLS2_k127_4719911_4 and related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003397 276.0
TLS2_k127_4719911_5 - - - - 0.000000000006713 75.0
TLS2_k127_4732526_0 Bacterial regulatory proteins, crp family - - - 0.000000000000000000000000000000000000000000002802 172.0
TLS2_k127_4732526_1 Pfam:N_methyl_2 - - - 0.0000003416 60.0
TLS2_k127_4732526_2 Belongs to the N-Me-Phe pilin family K02650 - - 0.000488 48.0
TLS2_k127_4735486_0 - - - - 0.00000000000000000000000000000000000000000000000000000255 212.0
TLS2_k127_4735486_1 - - - - 0.0005626 51.0
TLS2_k127_4737560_0 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008164 307.0
TLS2_k127_4737560_1 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000003117 109.0
TLS2_k127_4763933_0 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 6.962e-237 748.0
TLS2_k127_4763933_1 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 336.0
TLS2_k127_4763933_2 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001335 265.0
TLS2_k127_4763933_3 Dodecin K09165 - - 0.000000000002462 69.0
TLS2_k127_4763933_4 PD-(D/E)XK nuclease superfamily - - - 0.00000007374 62.0
TLS2_k127_4766673_1 Phage derived protein Gp49-like (DUF891) - - - 0.00000000000000000000000000000000000000003885 154.0
TLS2_k127_4766673_2 sequence-specific DNA binding - - - 0.000000000000000000000000000000000009418 140.0
TLS2_k127_4766673_3 - - - - 0.00000000000000000000000000000001721 129.0
TLS2_k127_4766673_4 HAF family - - - 0.00000000000000000268 90.0
TLS2_k127_4770289_0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term - - - 0.0 1158.0
TLS2_k127_4770289_1 Cleaves the N-terminal amino acid of tripeptides K01258 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001886 279.0
TLS2_k127_4778829_0 NapC/NirT cytochrome c family, N-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 459.0
TLS2_k127_4778829_1 peptidase U61 LD-carboxypeptidase A K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000000000000000000000000000000001586 261.0
TLS2_k127_4778829_2 Peptidase M48 - - - 0.0000005263 59.0
TLS2_k127_4802453_0 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 356.0
TLS2_k127_4802453_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000001405 257.0
TLS2_k127_4802453_2 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000000000283 118.0
TLS2_k127_4802453_3 PFAM single-stranded nucleic acid binding R3H domain protein K06346 - - 0.0000000000000000000000306 104.0
TLS2_k127_4802453_4 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000001624 80.0
TLS2_k127_4802453_5 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000004408 51.0
TLS2_k127_4802453_6 Belongs to the ParB family K03497 - - 0.0001546 46.0
TLS2_k127_4812631_0 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000007813 207.0
TLS2_k127_4812631_1 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843 - - 0.000000000000000000000000000000000000000143 160.0
TLS2_k127_4812631_2 Phospholipid methyltransferase - - - 0.0000000000000000000000000001519 122.0
TLS2_k127_4812631_3 Protein of unknown function (DUF3108) - - - 0.000000000000003651 87.0
TLS2_k127_481833_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 411.0
TLS2_k127_481833_1 - - - - 0.0000000000000000008266 88.0
TLS2_k127_4820460_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989,K02428 - 2.7.7.56,3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 295.0
TLS2_k127_4820460_1 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001941 286.0
TLS2_k127_4820460_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000001143 177.0
TLS2_k127_4820460_3 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000007627 123.0
TLS2_k127_4820460_4 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000221 99.0
TLS2_k127_4820460_5 Sporulation and spore germination - - - 0.0000001527 60.0
TLS2_k127_4823728_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005837 340.0
TLS2_k127_4823728_1 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 336.0
TLS2_k127_4823728_2 Domain of unknown function (DUF5107) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001976 275.0
TLS2_k127_4834458_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004588 317.0
TLS2_k127_4834458_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000001699 127.0
TLS2_k127_4834458_2 peptidyl-tyrosine sulfation - - - 0.00000000000007904 79.0
TLS2_k127_4847423_0 Glutamate dehydrogenase K15371 - 1.4.1.2 1.05e-236 764.0
TLS2_k127_4847423_1 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007424 338.0
TLS2_k127_4847423_2 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000002631 235.0
TLS2_k127_4847423_3 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000001838 128.0
TLS2_k127_4847423_4 Putative zinc-finger - - - 0.000000000000001712 89.0
TLS2_k127_4868709_0 PFAM Acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 2.169e-223 702.0
TLS2_k127_4868709_1 Na+-transporting oxaloacetate decarboxylase beta subunit K01572 - 4.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000768 612.0
TLS2_k127_4868709_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 543.0
TLS2_k127_4868709_3 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000385 271.0
TLS2_k127_4868709_4 acetyltransferase K18815 - 2.3.1.82 0.000000000000000000000000000000000513 132.0
TLS2_k127_4868709_5 - - - - 0.0000000000000000000000000000276 136.0
TLS2_k127_4868709_6 ligase activity, forming carbon-carbon bonds K00627,K01960,K20140 - 2.3.1.12,6.4.1.1,6.4.1.7 0.00000000000000000000001212 104.0
TLS2_k127_4868709_7 - - - - 0.0000000000001595 83.0
TLS2_k127_4868709_8 PFAM GCN5-related N-acetyltransferase K03789 - 2.3.1.128 0.00001727 54.0
TLS2_k127_4870880_0 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 549.0
TLS2_k127_4870880_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009377 456.0
TLS2_k127_4870880_2 CoA-binding K09181 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 365.0
TLS2_k127_4870880_3 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 344.0
TLS2_k127_4870880_4 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007029 319.0
TLS2_k127_4870880_5 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000002092 181.0
TLS2_k127_4870880_6 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000004306 143.0
TLS2_k127_4870880_7 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000002951 129.0
TLS2_k127_4870880_8 Regulatory protein, FmdB - - - 0.00000000000000000000002505 102.0
TLS2_k127_4870880_9 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000007633 81.0
TLS2_k127_4872563_0 Protein of unknown function (DUF1553) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 444.0
TLS2_k127_4872563_1 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 377.0
TLS2_k127_4872747_0 Concanavalin A-like lectin/glucanases superfamily K01190 - 3.2.1.23 0.0 1159.0
TLS2_k127_4872747_1 peptidyl-tyrosine sulfation K01277 - 3.4.14.4 8.484e-277 868.0
TLS2_k127_4872747_2 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001329 257.0
TLS2_k127_4872747_3 TIGRFAM para-aminobenzoate synthase, subunit I K01665,K03342 - 2.6.1.85,4.1.3.38 0.00000000000000000000000003317 109.0
TLS2_k127_4872779_0 PFAM Cytochrome b b6 domain - - - 1.691e-212 671.0
TLS2_k127_4872779_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 566.0
TLS2_k127_4872779_2 2 iron, 2 sulfur cluster binding - - - 0.00000000000000000000000000000000000008161 148.0
TLS2_k127_4872779_3 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000003659 138.0
TLS2_k127_4872779_4 Cytochrome c K02305 - - 0.00000000000000000000000001862 122.0
TLS2_k127_4875645_0 Heparinase II/III-like protein - - - 2.087e-255 801.0
TLS2_k127_4875645_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00627 GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 485.0
TLS2_k127_4875645_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 362.0
TLS2_k127_4875645_3 pyruvate dehydrogenase (acetyl-transferring) activity K00163 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 343.0
TLS2_k127_4875645_4 PFAM Organic solvent tolerance protein K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007539 293.0
TLS2_k127_4875645_5 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000002476 203.0
TLS2_k127_4875645_6 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.0000000000000000000000000000000000007217 149.0
TLS2_k127_4887686_0 PFAM Pyrrolo-quinoline quinone K00117 - 1.1.5.2 1.017e-203 653.0
TLS2_k127_4887686_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 570.0
TLS2_k127_4887686_2 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000002098 268.0
TLS2_k127_4887686_3 serine-type peptidase activity K06978,K21105 - 3.1.1.102 0.000000000000000000000000000000000000000000004988 180.0
TLS2_k127_4887686_4 Glycosyl Hydrolase Family 88 - - - 0.0000000000001427 82.0
TLS2_k127_4888635_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 1.679e-197 620.0
TLS2_k127_4888635_1 PFAM glycosyl transferase, family 51 - - - 0.000000000000000000000000000000000000000000000000000000000000000003519 231.0
TLS2_k127_4893809_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 539.0
TLS2_k127_4893809_1 Alanine dehydrogenase/PNT, C-terminal domain K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 428.0
TLS2_k127_4893809_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 304.0
TLS2_k127_4893809_3 Adenosine/AMP deaminase K01488,K18286,K21053 GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.4.2,3.5.4.4,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000003536 232.0
TLS2_k127_4893809_4 COG3288 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.000000000000000000000000000006093 126.0
TLS2_k127_4893809_5 PFAM Bacterial regulatory proteins, gntR family K07979 - - 0.00000002493 65.0
TLS2_k127_4893809_6 PFAM major facilitator superfamily MFS_1 - - - 0.0001025 49.0
TLS2_k127_4904061_0 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 339.0
TLS2_k127_4904061_1 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000001858 224.0
TLS2_k127_4904061_2 Protein of unknown function (DUF4038) - - - 0.000000000000000000000000000002458 123.0
TLS2_k127_4906460_0 - - - - 0.000000000000000000000000000000000000007442 155.0
TLS2_k127_4906460_1 Two component regulator propeller - - - 0.000000000000000000000000000002485 136.0
TLS2_k127_4906460_2 PFAM periplasmic copper-binding K01385 - 3.4.23.42 0.0005655 50.0
TLS2_k127_4906486_0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 597.0
TLS2_k127_4906486_1 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 409.0
TLS2_k127_4906486_2 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000004235 216.0
TLS2_k127_4906486_3 nUDIX hydrolase - - - 0.0000000000000000000000000000000000000000000000000001774 191.0
TLS2_k127_4907057_0 periplasmic solute binding protein K02077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 376.0
TLS2_k127_4907057_1 pfam abc-3 K09816 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001857 264.0
TLS2_k127_4907057_2 (ABC) transporter - - - 0.0000000000000000000000000000000000000000000000000000002488 199.0
TLS2_k127_4907057_3 growth of symbiont in host cell K07003 - - 0.00000000000000000000001846 104.0
TLS2_k127_4908224_0 Protein of unknown function (DUF2971) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 391.0
TLS2_k127_4908224_1 metal-dependent phosphohydrolase, HD sub domain K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000227 106.0
TLS2_k127_4908224_3 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000004446 75.0
TLS2_k127_4909052_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 7.604e-244 770.0
TLS2_k127_4909052_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 490.0
TLS2_k127_4909052_10 PFAM Transposase IS116 IS110 IS902 family - - - 0.000002243 56.0
TLS2_k127_4909052_2 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 435.0
TLS2_k127_4909052_3 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 369.0
TLS2_k127_4909052_4 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007324 342.0
TLS2_k127_4909052_5 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 329.0
TLS2_k127_4909052_6 PFAM peptidase S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005947 297.0
TLS2_k127_4909052_7 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000001741 226.0
TLS2_k127_4909052_8 Protein of unknown function (DUF423) - - - 0.00000000000000000000000000000000000000001153 157.0
TLS2_k127_4909052_9 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000000000000004959 111.0
TLS2_k127_4910595_0 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002921 257.0
TLS2_k127_4910595_1 lipoprotein localization to outer membrane K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006426 256.0
TLS2_k127_4910595_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000000000006659 202.0
TLS2_k127_4910595_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000006775 166.0
TLS2_k127_4910595_4 helix_turn_helix, mercury resistance K13640 - - 0.00000000000000000000000000000000000001487 148.0
TLS2_k127_4910595_5 PFAM SNARE associated Golgi protein - - - 0.0000000000000002593 87.0
TLS2_k127_4910595_6 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000007389 80.0
TLS2_k127_4910595_7 COG2834 Outer membrane lipoprotein-sorting protein - - - 0.0000000001146 70.0
TLS2_k127_4911436_0 Alpha amylase, C-terminal all-beta domain K00700 - 2.4.1.18 0.0 1186.0
TLS2_k127_4911436_1 thiolester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003798 287.0
TLS2_k127_4911436_2 PhoD-like phosphatase K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000234 239.0
TLS2_k127_4911436_3 Dodecin K09165 - - 0.00000000000000000008562 90.0
TLS2_k127_491469_0 Amino acid kinase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 313.0
TLS2_k127_491469_1 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000004914 237.0
TLS2_k127_491469_2 lysyltransferase activity K07027 - - 0.0000000000000000000000003839 117.0
TLS2_k127_491741_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008349 255.0
TLS2_k127_491741_1 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001022 236.0
TLS2_k127_491741_2 domain protein - - - 0.000000000000000004216 87.0
TLS2_k127_491741_3 domain protein - - - 0.0000000000000000634 82.0
TLS2_k127_4917880_0 Peptidase family M1 domain K01256 - 3.4.11.2 7.792e-244 774.0
TLS2_k127_4917880_1 Putative adhesin - - - 0.0000000000000000000000000000000000001846 149.0
TLS2_k127_4919368_0 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005828 537.0
TLS2_k127_4919368_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 430.0
TLS2_k127_4919368_2 xyloglucan:xyloglucosyl transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 336.0
TLS2_k127_4919368_3 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 304.0
TLS2_k127_4919368_4 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007327 280.0
TLS2_k127_4919368_5 Chemotaxis protein CheC, inhibitor of MCP methylation K03410 - - 0.00000000000000000000000000000000000000000000001868 178.0
TLS2_k127_4919368_6 response regulator, receiver K02658,K03413 - - 0.000000000000000000000000000008425 123.0
TLS2_k127_4952738_0 Beta-galactosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009722 439.0
TLS2_k127_4952738_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000000000000000000004913 164.0
TLS2_k127_4952738_2 amidohydrolase - - - 0.0000000000000001119 80.0
TLS2_k127_4952738_3 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source K10778 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944 2.1.1.63 0.000000000007981 68.0
TLS2_k127_4993383_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 507.0
TLS2_k127_4993383_1 Fe-S oxidoreductases K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 379.0
TLS2_k127_4993383_2 Cytochrome c K02198 - - 0.0000000000000000000000000000000000000002177 162.0
TLS2_k127_4993383_3 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.00000000000000000000000000000472 124.0
TLS2_k127_4993383_4 FeoA K04758 - - 0.00001479 50.0
TLS2_k127_4995261_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 410.0
TLS2_k127_4995261_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671,K22345 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9,4.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 336.0
TLS2_k127_4995261_2 Tetratricopeptide TPR_2 repeat protein - - - 0.00003364 50.0
TLS2_k127_5007061_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 2.58e-206 658.0
TLS2_k127_5007061_1 lipid kinase, YegS Rv2252 BmrU family - - - 0.000000000000000000000000000000000000000000000003543 185.0
TLS2_k127_5007061_2 metal-sulfur cluster biosynthetic enzyme K02612 - - 0.0000000000000000000000000000000000003524 142.0
TLS2_k127_5007061_3 NifU-like N terminal domain K04488 - - 0.00000000000000008147 81.0
TLS2_k127_5007061_4 Catalyzes the reduction of fatty acyl-CoA to fatty alcohols K13356 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009555,GO:0009653,GO:0009698,GO:0009699,GO:0009987,GO:0010208,GO:0010345,GO:0010584,GO:0010927,GO:0016043,GO:0016491,GO:0016620,GO:0016627,GO:0016628,GO:0016903,GO:0019438,GO:0019637,GO:0019693,GO:0019748,GO:0022607,GO:0030198,GO:0032501,GO:0032502,GO:0032989,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035336,GO:0035337,GO:0035383,GO:0043062,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044424,GO:0044464,GO:0044550,GO:0045229,GO:0046483,GO:0048229,GO:0048646,GO:0048856,GO:0048869,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:0080019,GO:0085029,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901568,GO:1901576 1.2.1.84 0.00000000001647 65.0
TLS2_k127_5008252_0 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 482.0
TLS2_k127_5008252_1 PFAM ATP-binding region, ATPase domain protein domain protein K07683 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004258 314.0
TLS2_k127_5008252_2 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 288.0
TLS2_k127_5010009_0 Belongs to the RtcB family K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 573.0
TLS2_k127_5010009_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 410.0
TLS2_k127_5010009_2 chitin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 340.0
TLS2_k127_5010009_3 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 325.0
TLS2_k127_5010009_4 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000007063 199.0
TLS2_k127_5010009_5 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000005345 198.0
TLS2_k127_5010009_6 PFAM Archease protein family (DUF101 UPF0211) - - - 0.000000000000000000000000000000000000000002583 159.0
TLS2_k127_5010009_7 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00574,K07755 - 2.1.1.137,2.1.1.79 0.000000000001037 72.0
TLS2_k127_5041359_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 527.0
TLS2_k127_5041359_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006314 389.0
TLS2_k127_5041359_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003796 287.0
TLS2_k127_5041359_3 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000002028 237.0
TLS2_k127_5041359_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000001511 194.0
TLS2_k127_5041359_5 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000003386 145.0
TLS2_k127_5041359_6 JAB/MPN domain K21140 - 3.13.1.6 0.000000000000000000003429 98.0
TLS2_k127_5041359_7 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000008878 51.0
TLS2_k127_5043143_0 Radical SAM - - - 5.519e-291 910.0
TLS2_k127_5043143_1 PFAM glycoside hydrolase family 29 K01206 - 3.2.1.51 8.762e-229 718.0
TLS2_k127_5043143_2 L-rhamnose isomerase K01813 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008740,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.14 3.912e-201 633.0
TLS2_k127_5043143_3 Oxidoreductase family, C-terminal alpha/beta domain - - - 8.298e-201 635.0
TLS2_k127_5043143_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 556.0
TLS2_k127_5043143_5 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 436.0
TLS2_k127_5043143_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 312.0
TLS2_k127_5049758_0 - - - - 4.359e-242 771.0
TLS2_k127_5049758_2 Belongs to the DapA family - - - 0.0000000001052 72.0
TLS2_k127_5053134_0 amine dehydrogenase activity K20276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 388.0
TLS2_k127_5053134_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 350.0
TLS2_k127_5058650_0 PFAM Uncharacterised BCR, COG1649 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 537.0
TLS2_k127_5059563_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835 GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576 5.4.2.2 1.94e-247 775.0
TLS2_k127_5059563_1 PFAM Glycosyl transferase, family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 569.0
TLS2_k127_5059563_10 ethanolamine catabolic process K04027 - - 0.00000000004076 68.0
TLS2_k127_5059563_11 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000004534 67.0
TLS2_k127_5059563_12 snoRNA binding - - - 0.000000009858 63.0
TLS2_k127_5059563_2 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007026 480.0
TLS2_k127_5059563_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 422.0
TLS2_k127_5059563_4 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 405.0
TLS2_k127_5059563_5 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 391.0
TLS2_k127_5059563_6 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 295.0
TLS2_k127_5059563_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001398 240.0
TLS2_k127_5059563_8 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000002228 205.0
TLS2_k127_5059563_9 FecR protein - - - 0.00000000000000000000000000000000000000000000000000001242 204.0
TLS2_k127_5081169_0 Peptidase family M3 K01284,K01414 - 3.4.15.5,3.4.24.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 483.0
TLS2_k127_5081169_1 PFAM Peptidase family M3 K01284 - 3.4.15.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 386.0
TLS2_k127_5087926_0 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 301.0
TLS2_k127_5087926_1 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.0000000000000000000000000000000000000000001836 168.0
TLS2_k127_5095774_0 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 428.0
TLS2_k127_5095774_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000002195 77.0
TLS2_k127_5095774_2 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.00001289 53.0
TLS2_k127_5099088_0 AAA-like domain - - - 1.624e-203 640.0
TLS2_k127_5099088_1 - - - - 0.0000000000000000000000000000000000000000000000000000000002178 211.0
TLS2_k127_5106913_0 PLD-like domain K06131 - - 4.62e-206 651.0
TLS2_k127_5106913_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 574.0
TLS2_k127_5106913_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 437.0
TLS2_k127_5106913_3 IclR helix-turn-helix domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 303.0
TLS2_k127_5106913_4 PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain K07443 - - 0.000000000000000000000002182 105.0
TLS2_k127_5110149_0 membrane organization K07277,K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001077 302.0
TLS2_k127_5110652_0 dna ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001905 257.0
TLS2_k127_5110652_1 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000004224 213.0
TLS2_k127_5118709_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 2.288e-238 756.0
TLS2_k127_5118709_1 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 561.0
TLS2_k127_5118709_2 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 317.0
TLS2_k127_5125469_0 N-acetylglucosaminylinositol deacetylase activity K01463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 392.0
TLS2_k127_5125469_1 Glucose dehydrogenase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 319.0
TLS2_k127_5125469_2 carbohydrate kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001136 269.0
TLS2_k127_5140743_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 325.0
TLS2_k127_5140743_1 Methyltransferase - - - 0.0000000000000000000000000000000000000000000001374 178.0
TLS2_k127_5140743_2 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000005601 151.0
TLS2_k127_5140743_3 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179,K13276 - 3.2.1.4 0.000000000000002712 90.0
TLS2_k127_5146337_0 Ftsk_gamma K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 561.0
TLS2_k127_5146337_1 PFAM von Willebrand factor type A K07114 - - 0.0000000000000000000000000000000000001713 149.0
TLS2_k127_5146426_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 376.0
TLS2_k127_5147370_0 xylulokinase activity K00854 - 2.7.1.17 9.725e-197 630.0
TLS2_k127_5147370_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007295 448.0
TLS2_k127_5147370_2 fructose-bisphosphate aldolase activity K01624,K08302 - 4.1.2.13,4.1.2.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 286.0
TLS2_k127_5149571_0 and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 563.0
TLS2_k127_5149571_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000001961 177.0
TLS2_k127_5150431_0 FAD dependent oxidoreductase - - - 3.05e-204 653.0
TLS2_k127_5150431_1 cheY-homologous receiver domain - - - 0.0000000000000000000000000001136 119.0
TLS2_k127_5150431_2 chemotaxis protein K03410 - - 0.00000000000000000006751 97.0
TLS2_k127_5155087_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003342 250.0
TLS2_k127_5155087_1 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000002385 158.0
TLS2_k127_517935_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 531.0
TLS2_k127_517935_1 peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005135 451.0
TLS2_k127_517935_2 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.0000000000000000000000000000000000000000000000000000003006 209.0
TLS2_k127_5185974_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.972e-286 889.0
TLS2_k127_5185974_1 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 331.0
TLS2_k127_5185974_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000000000000000000000001706 202.0
TLS2_k127_5185974_3 XanTHIne and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.000000000000000000000000000000000000000000000008401 177.0
TLS2_k127_5195843_0 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K00663,K03790 - 2.3.1.128,2.3.1.82 0.0000000000000000000000000000000000000000000000004833 189.0
TLS2_k127_5195843_1 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000001446 184.0
TLS2_k127_5195843_2 - - - - 0.0000000000000000000000000000001265 128.0
TLS2_k127_5195843_3 cellulose binding - - - 0.000000000000000000000000001542 129.0
TLS2_k127_5199994_0 exo-alpha-(2->6)-sialidase activity K01179,K01186 - 3.2.1.18,3.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 443.0
TLS2_k127_5199994_1 MacB-like periplasmic core domain - - - 0.00001578 52.0
TLS2_k127_5212775_0 Putative collagen-binding domain of a collagenase - - - 9.222e-269 840.0
TLS2_k127_5212775_1 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000001753 159.0
TLS2_k127_5212775_2 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000001245 152.0
TLS2_k127_5213613_0 Belongs to the glycosyl hydrolase 3 family K05349,K17641 - 3.2.1.21 1.421e-208 685.0
TLS2_k127_5213613_1 PFAM Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 336.0
TLS2_k127_5213613_2 Cys-tRNA(Pro) hydrolase activity K03976,K19055 - - 0.00000000000000000000000000000000000000000000000000000000001536 213.0
TLS2_k127_5213613_3 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.00000000000000000000002757 106.0
TLS2_k127_5213613_4 - - - - 0.0000000000005587 76.0
TLS2_k127_5214170_0 C-terminal binding-module, SLH-like, of glucodextranase - - - 2.851e-246 774.0
TLS2_k127_5218074_0 cobalamin-transporting ATPase activity K02014 - - 2.795e-213 682.0
TLS2_k127_5218074_1 Hypothetical glycosyl hydrolase 6 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 549.0
TLS2_k127_5218074_2 transcriptional regulator K07722 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000001388 162.0
TLS2_k127_5218074_3 - - - - 0.00000000000000005863 96.0
TLS2_k127_522157_0 beta-glucosidase activity K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001837 284.0
TLS2_k127_522157_1 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002517 278.0
TLS2_k127_522157_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0006991 51.0
TLS2_k127_5225226_0 response regulator, receiver K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 327.0
TLS2_k127_5225226_1 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000007599 278.0
TLS2_k127_5225226_2 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000002456 192.0
TLS2_k127_5228623_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.341e-245 769.0
TLS2_k127_5228623_1 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 547.0
TLS2_k127_5228623_10 Colicin V production protein K03558 - - 0.0000000007464 67.0
TLS2_k127_5228623_11 Bacterial regulatory protein, Fis family - - - 0.00000007443 57.0
TLS2_k127_5228623_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000678 502.0
TLS2_k127_5228623_3 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 390.0
TLS2_k127_5228623_4 SpoIVB peptidase S55 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 385.0
TLS2_k127_5228623_5 self proteolysis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003889 299.0
TLS2_k127_5228623_6 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008856 276.0
TLS2_k127_5228623_7 dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000001154 208.0
TLS2_k127_5228623_8 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000001889 144.0
TLS2_k127_5228623_9 Serine aminopeptidase, S33 K06889 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136 - 0.0000000001588 72.0
TLS2_k127_5234307_0 Uncharacterized protein conserved in bacteria (DUF2264) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 536.0
TLS2_k127_5234307_1 Fibronectin type 3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 426.0
TLS2_k127_5234307_3 PFAM ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000366 393.0
TLS2_k127_5234307_4 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000007073 229.0
TLS2_k127_5254255_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 3.655e-309 967.0
TLS2_k127_5254255_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 614.0
TLS2_k127_5254255_2 L,D-transpeptidase catalytic domain - - - 0.00006702 53.0
TLS2_k127_5258027_0 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005658 326.0
TLS2_k127_5258027_1 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000003097 168.0
TLS2_k127_5258027_2 PFAM Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000002168 154.0
TLS2_k127_5259921_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 469.0
TLS2_k127_5259921_1 Glycoside hydrolase family 3 domain protein K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 418.0
TLS2_k127_5259921_2 homoserine kinase activity K02204,K13059 - 2.7.1.162,2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 410.0
TLS2_k127_5259921_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 361.0
TLS2_k127_5259921_4 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007461 343.0
TLS2_k127_5259921_5 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 325.0
TLS2_k127_5259921_6 Methyltransferase domain K22309 - 2.1.1.344 0.00000000000000000000000000000000000000003547 156.0
TLS2_k127_5259921_7 S-layer homology domain - - - 0.000000000000000000000000006233 117.0
TLS2_k127_5265201_0 Catalyzes the dehydration of D-mannonate K01686 - 4.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 452.0
TLS2_k127_5265201_1 SMART metal-dependent phosphohydrolase, HD region K01139 - 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000000000000000000001621 182.0
TLS2_k127_5265201_2 pyrroloquinoline quinone binding - - - 0.0000000001276 67.0
TLS2_k127_5269086_0 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 393.0
TLS2_k127_5269086_1 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 323.0
TLS2_k127_5269086_2 PFAM oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001521 277.0
TLS2_k127_5271180_0 PFAM glycosidase PH1107-related K18785,K20885 - 2.4.1.319,2.4.1.320,2.4.1.339,2.4.1.340 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 516.0
TLS2_k127_5271180_1 PFAM glycosidase, PH1107-related K20885 - 2.4.1.339,2.4.1.340 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 471.0
TLS2_k127_5271180_2 beta-N-acetylhexosaminidase activity K12373 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009846 487.0
TLS2_k127_5271180_3 Major facilitator Superfamily K03292,K16248 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004333 456.0
TLS2_k127_5271180_4 PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 347.0
TLS2_k127_5271180_5 cAMP biosynthetic process K03641 - - 0.00000000000000000000000000000000000000000000000001708 188.0
TLS2_k127_5271180_6 Lysin motif - - - 0.000000000000000000000000000000000000000004598 159.0
TLS2_k127_5271180_7 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000002957 153.0
TLS2_k127_5273074_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1033.0
TLS2_k127_5273074_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 370.0
TLS2_k127_5273074_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000002849 208.0
TLS2_k127_5273074_3 Osmosensitive K channel His kinase sensor - - - 0.00000000000000000000000000000000000004119 148.0
TLS2_k127_5274660_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 337.0
TLS2_k127_5274660_1 dehydrogenases and related proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 291.0
TLS2_k127_527510_0 PFAM Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 488.0
TLS2_k127_527510_1 glycosyl transferase, family 9 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 394.0
TLS2_k127_527510_2 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005313 246.0
TLS2_k127_527510_3 oxidoreductase activity - - - 0.0000002897 61.0
TLS2_k127_5277832_0 Elongator protein 3, MiaB family, Radical SAM K22318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004155 555.0
TLS2_k127_5277832_1 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 370.0
TLS2_k127_5277832_2 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 317.0
TLS2_k127_5277832_3 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000001409 241.0
TLS2_k127_5291572_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 422.0
TLS2_k127_5291572_1 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000002957 211.0
TLS2_k127_5291572_2 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000000000000009498 192.0
TLS2_k127_5291572_3 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000003694 132.0
TLS2_k127_5293821_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000072 445.0
TLS2_k127_5293821_1 Sucrose-6F-phosphate phosphohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 391.0
TLS2_k127_53145_0 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000000000004214 154.0
TLS2_k127_53145_1 Peptidase M16 inactive domain K07263,K07623 - - 0.00000000005198 75.0
TLS2_k127_53145_2 Participates in both transcription termination and antitermination K02600 - - 0.000000001697 61.0
TLS2_k127_5317349_0 carbon starvation protein CstA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 477.0
TLS2_k127_5317349_1 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 382.0
TLS2_k127_5317349_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000001587 244.0
TLS2_k127_5317349_3 Pyridoxamine 5'-phosphate oxidase K00275 - 1.4.3.5 0.0000000000000000000000001931 113.0
TLS2_k127_5317349_4 efflux transmembrane transporter activity - - - 0.000000000000000000002971 103.0
TLS2_k127_5317349_5 Belongs to the peptidase S8 family K14645 - - 0.0000000000000000006702 97.0
TLS2_k127_5340091_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006944 561.0
TLS2_k127_5340091_1 Uroporphyrinogen decarboxylase (URO-D) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 396.0
TLS2_k127_5347458_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 458.0
TLS2_k127_5347458_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 413.0
TLS2_k127_5347458_2 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005581 377.0
TLS2_k127_5347458_3 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 357.0
TLS2_k127_5347458_4 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000005836 88.0
TLS2_k127_5347458_5 Protein of unknown function (DUF2905) - - - 0.000000000000193 72.0
TLS2_k127_5347612_0 DegT/DnrJ/EryC1/StrS aminotransferase family K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005085 490.0
TLS2_k127_5347612_1 Transcriptional regulator K07013 - - 0.00000000000000000000000000000000000000000002959 168.0
TLS2_k127_5348626_0 Glycosyl-hydrolase 97 C-terminal, oligomerisation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 548.0
TLS2_k127_5348626_1 protocatechuate 3,4-dioxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001181 258.0
TLS2_k127_5348626_2 purine nucleotide biosynthetic process K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000003212 232.0
TLS2_k127_53505_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008434 385.0
TLS2_k127_53505_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006122 282.0
TLS2_k127_53505_2 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.000000000000000000000000000000000000000000000000000000000009963 234.0
TLS2_k127_53505_3 outer membrane autotransporter barrel domain protein - - - 0.0000000000000000002864 96.0
TLS2_k127_5368136_0 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 548.0
TLS2_k127_5368136_1 COGs COG0471 Di- and tricarboxylate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 416.0
TLS2_k127_5368136_2 Peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 396.0
TLS2_k127_5368136_3 Zincin-like metallopeptidase - - - 0.00000000000000000000000004317 111.0
TLS2_k127_5368136_4 Transmembrane proteins 14C - - - 0.0000000000001149 75.0
TLS2_k127_5369072_0 glycosyltransferase 36 associated K00702,K13688 - 2.4.1.20 1.29e-201 654.0
TLS2_k127_5384858_0 ASPIC and UnbV - - - 1.23e-211 668.0
TLS2_k127_5384858_1 cluster binding protein K18929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008788 441.0
TLS2_k127_5384858_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K00945,K02945,K03527 - 1.17.7.4,2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 359.0
TLS2_k127_5384858_3 Cysteine-rich domain K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001573 248.0
TLS2_k127_5384858_4 PFAM Uncharacterised ACR, YkgG family COG1556 K00782 - - 0.00000000001018 75.0
TLS2_k127_5395684_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.071e-240 760.0
TLS2_k127_5395684_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 342.0
TLS2_k127_5395684_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000001538 168.0
TLS2_k127_5395684_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000002522 115.0
TLS2_k127_5400232_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000001734 208.0
TLS2_k127_5400232_1 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000002397 165.0
TLS2_k127_5400232_2 integral membrane protein - - - 0.0001502 50.0
TLS2_k127_5401422_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006911 570.0
TLS2_k127_5401422_1 PFAM Protein phosphatase 2C K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000007935 166.0
TLS2_k127_5401422_2 Domain of unknown function (DUF4416) - - - 0.0000000000000000000000000000001265 130.0
TLS2_k127_5401422_3 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 0.000005413 55.0
TLS2_k127_5404581_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 384.0
TLS2_k127_5404581_1 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 337.0
TLS2_k127_5404581_2 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001904 282.0
TLS2_k127_5404581_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000006133 212.0
TLS2_k127_5406156_0 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 4.575e-203 647.0
TLS2_k127_5406156_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 601.0
TLS2_k127_5406156_2 STAS domain - - - 0.0000004238 58.0
TLS2_k127_5413898_0 Belongs to the glycosyl hydrolase 30 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 514.0
TLS2_k127_5413898_1 Tannase and feruloyl esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005809 263.0
TLS2_k127_5422165_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 582.0
TLS2_k127_5422165_1 PFAM Major Facilitator Superfamily K08191 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 548.0
TLS2_k127_5422165_10 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002279 290.0
TLS2_k127_5422165_11 Kinase/pyrophosphorylase K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000000002079 239.0
TLS2_k127_5422165_12 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000003323 192.0
TLS2_k127_5422165_13 tagaturonate epimerase K21619 - 5.1.2.7 0.0000000000000000000005846 100.0
TLS2_k127_5422165_14 Insulinase (Peptidase family M16) K07263 - - 0.0000008305 59.0
TLS2_k127_5422165_2 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 533.0
TLS2_k127_5422165_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006211 436.0
TLS2_k127_5422165_4 mannose-1-phosphate guanylyltransferase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 329.0
TLS2_k127_5422165_5 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 328.0
TLS2_k127_5422165_6 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007667 317.0
TLS2_k127_5422165_7 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 309.0
TLS2_k127_5422165_8 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 298.0
TLS2_k127_5422165_9 peptidase dimerisation domain protein K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006695 297.0
TLS2_k127_5428476_0 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 378.0
TLS2_k127_5428476_1 pfkB family carbohydrate kinase K18478 - 2.7.1.184 0.0000000000000000000000000000000000000000000000000000000000005647 225.0
TLS2_k127_5428476_2 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000001066 203.0
TLS2_k127_5428476_3 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000002409 192.0
TLS2_k127_5428476_4 - - - - 0.000000000000000000000000000000000000000000000000004381 192.0
TLS2_k127_5433128_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 547.0
TLS2_k127_5433128_1 Inner membrane protein CreD K06143 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 415.0
TLS2_k127_5439831_0 family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 339.0
TLS2_k127_5439831_1 - - - - 0.00000000000000000001795 102.0
TLS2_k127_5439831_2 - - - - 0.00004516 53.0
TLS2_k127_544641_0 domain, Protein - - - 0.0000000000000000000000000000000000000000000666 177.0
TLS2_k127_544641_1 DinB superfamily - - - 0.00000000000000000000000000000000000008486 149.0
TLS2_k127_544641_2 Protein of unknown function DUF89 K09116 - - 0.00000000000002089 76.0
TLS2_k127_544641_3 Short-chain dehydrogenase reductase sdr - - - 0.000002042 53.0
TLS2_k127_5453471_0 Thioesterase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 431.0
TLS2_k127_5453471_1 thioesterase involved in non-ribosomal peptide biosynthesis K01071 - 3.1.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 332.0
TLS2_k127_5453471_2 MbtH-like protein K05375,K09190 - - 0.000000000000000000000000000004853 121.0
TLS2_k127_5453471_3 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000103 73.0
TLS2_k127_5456988_0 glycosyltransferase 36 associated K00702,K13688 - 2.4.1.20 5.45e-219 693.0
TLS2_k127_5456988_1 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 400.0
TLS2_k127_5456988_2 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 338.0
TLS2_k127_5456988_3 Acyl-CoA dehydrogenase, C-terminal domain K00248,K09478 - 1.3.8.1,1.3.99.12 0.0000000000000000000000000000000000000000000000000000000000003048 217.0
TLS2_k127_5456988_4 redox protein regulator of disulfide bond formation K04063 - - 0.000000000000000000000000000000000000000000000000003349 184.0
TLS2_k127_5456988_5 at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA) K04751,K04752 - - 0.0000000000000000000000000000000000000000000006325 168.0
TLS2_k127_5456988_6 - - - - 0.000000000000000000000009641 111.0
TLS2_k127_5456988_7 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000009858 104.0
TLS2_k127_5456988_8 Response regulator, receiver - - - 0.000000003617 63.0
TLS2_k127_5465762_0 Belongs to the glycosyl hydrolase 26 family K01218 - 3.2.1.78 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 378.0
TLS2_k127_5465762_1 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family K02100,K03444,K08138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 308.0
TLS2_k127_5473846_0 He_PIG associated, NEW1 domain of bacterial glycohydrolase K07407 - 3.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 570.0
TLS2_k127_5473846_1 Radical SAM superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 351.0
TLS2_k127_5477451_0 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 6.556e-289 903.0
TLS2_k127_5477451_1 4 iron, 4 sulfur cluster binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005873 355.0
TLS2_k127_5477451_2 Major Facilitator Superfamily - - - 0.000000000000001391 81.0
TLS2_k127_5479247_0 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 497.0
TLS2_k127_5479247_1 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000002835 237.0
TLS2_k127_5479247_2 Protein of unknown function (DUF1269) - - - 0.00000000000000000000000000000000000000000000000000000000000001186 219.0
TLS2_k127_5479247_3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000004744 153.0
TLS2_k127_5479247_4 Protein of unknown function (DUF3015) - - - 0.00000000000000000000000003375 114.0
TLS2_k127_5479247_5 Bacterial periplasmic substrate-binding proteins K02030,K10001 - - 0.0000000000000000000000004275 108.0
TLS2_k127_5489005_0 Glycosyl transferase - - - 0.000000000000000000000000000000000000000008606 169.0
TLS2_k127_5489005_1 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000000000000000005806 130.0
TLS2_k127_5489005_2 Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress K01091 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18 0.00000000000000000000000000000002042 135.0
TLS2_k127_5489005_3 Natural resistance-associated macrophage protein - - - 0.0000000000009393 77.0
TLS2_k127_5489005_4 cellulase activity - - - 0.0007833 48.0
TLS2_k127_5496358_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 372.0
TLS2_k127_5496358_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000001461 217.0
TLS2_k127_5496358_2 peptidase M23 - - - 0.00000000000000000000000000000000000000000000000000000001894 213.0
TLS2_k127_5496358_3 Conserved hypothetical protein 95 - - - 0.000000000000000000000000000000003777 136.0
TLS2_k127_5496358_4 CHAT domain - - - 0.0000000007349 73.0
TLS2_k127_5496358_5 AntiSigma factor - - - 0.00000003268 63.0
TLS2_k127_5496358_6 Sigma-70, region 4 K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00002742 54.0
TLS2_k127_5500492_0 TRCF K03723 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 581.0
TLS2_k127_5500492_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 418.0
TLS2_k127_5500492_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000000002575 232.0
TLS2_k127_5500492_3 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000000002153 195.0
TLS2_k127_5500492_4 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 0.0000000000000000000000003901 107.0
TLS2_k127_5500492_5 PFAM YbbR family protein - - - 0.00000000000000008068 89.0
TLS2_k127_5505505_0 ABC transporter K01990,K09697 - 3.6.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000835 273.0
TLS2_k127_5505505_1 ABC-2 family transporter protein K09696 - - 0.0000000000000000000000000000000001188 151.0
TLS2_k127_5505505_2 COG1668 ABC-type Na efflux pump, permease component K01992,K09696 - - 0.0000000000000000000001047 109.0
TLS2_k127_550645_0 Chlorite dismutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001343 251.0
TLS2_k127_550645_1 Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000124 202.0
TLS2_k127_550645_2 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000004641 189.0
TLS2_k127_550645_3 IstB-like ATP binding protein K02315,K04076 - 3.4.21.53 0.0000000000000000000000000000000000000003371 156.0
TLS2_k127_5521010_0 Glycosyltransferase like family 2 K07011 - - 0.0000000000000000000000000000000000002834 150.0
TLS2_k127_5521010_1 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000005951 112.0
TLS2_k127_5521010_2 PFAM glycosyl transferase family 2 K07011 - - 0.0000000000000000000007454 107.0
TLS2_k127_5521010_3 Glycosyltransferase like family 2 - - - 0.00000004884 64.0
TLS2_k127_5521436_0 PFAM alpha beta hydrolase fold K01563,K22318 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000393 329.0
TLS2_k127_5521436_1 PFAM AMP-dependent synthetase and ligase K22319 - 6.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001177 269.0
TLS2_k127_5521436_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000001758 88.0
TLS2_k127_554793_0 Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002448 284.0
TLS2_k127_554793_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000008492 249.0
TLS2_k127_5551699_0 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 297.0
TLS2_k127_5551699_1 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000007526 204.0
TLS2_k127_5551699_2 nuclease activity - GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0070482,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000005007 171.0
TLS2_k127_5551699_3 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000008693 168.0
TLS2_k127_5551699_4 - - - - 0.000000000000000000000000000000006594 131.0
TLS2_k127_5551699_5 Hypothetical glycosyl hydrolase 6 - - - 0.0000000000000000000000004962 122.0
TLS2_k127_5551699_6 positive regulation of growth - - - 0.0000000000000000357 82.0
TLS2_k127_5551699_7 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.0000000003595 63.0
TLS2_k127_5551699_8 efflux transmembrane transporter activity - - - 0.00005384 48.0
TLS2_k127_555628_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000005531 114.0
TLS2_k127_5560326_0 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 531.0
TLS2_k127_5560326_1 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 448.0
TLS2_k127_5560326_2 - - - - 0.00000000000000000000000000004739 120.0
TLS2_k127_5574590_0 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 449.0
TLS2_k127_5574590_1 Prephenate dehydratase K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008156 373.0
TLS2_k127_5574590_2 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 324.0
TLS2_k127_5574590_3 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 308.0
TLS2_k127_5574590_4 PFAM DNA mismatch repair protein MutS domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000001043 228.0
TLS2_k127_5575763_0 Domain of unknown function - - - 5.314e-227 717.0
TLS2_k127_5575763_1 Prolyl oligopeptidase K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009418 532.0
TLS2_k127_5578918_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008793 406.0
TLS2_k127_5578918_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000003206 195.0
TLS2_k127_5578918_2 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000006547 153.0
TLS2_k127_5578918_3 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000000000000000000000000001607 140.0
TLS2_k127_5585890_0 EXOIII K02342 - 2.7.7.7 1.112e-314 977.0
TLS2_k127_5585890_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000002123 216.0
TLS2_k127_5587745_0 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 570.0
TLS2_k127_5587745_1 alanine dehydrogenase activity K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 297.0
TLS2_k127_5587745_2 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000212 218.0
TLS2_k127_5591285_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000006945 245.0
TLS2_k127_5591285_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000009272 150.0
TLS2_k127_5609982_0 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000003654 198.0
TLS2_k127_5609982_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000001856 177.0
TLS2_k127_5609982_2 Phage integrase family - - - 0.000000000000001742 80.0
TLS2_k127_5620369_0 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 446.0
TLS2_k127_5620369_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 284.0
TLS2_k127_5620369_2 - - - - 0.000000000000000000000000000000000000000000000000000001778 203.0
TLS2_k127_5620369_3 PFAM Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000000578 194.0
TLS2_k127_5620369_4 Amidohydrolase family K06015 - 3.5.1.81 0.000000001071 61.0
TLS2_k127_5635182_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 348.0
TLS2_k127_5636645_0 Carboxypeptidase regulatory-like domain - - - 6.754e-235 771.0
TLS2_k127_5636645_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 344.0
TLS2_k127_5636645_2 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001374 285.0
TLS2_k127_5636645_3 transferase activity, transferring glycosyl groups K13659 - 2.4.1.264 0.000000000000001803 89.0
TLS2_k127_5646927_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 401.0
TLS2_k127_5646927_1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 302.0
TLS2_k127_5648307_0 Peptidase family M50 K06212,K06402 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 453.0
TLS2_k127_5648307_1 Surface antigen - - - 0.000000008155 67.0
TLS2_k127_5650684_0 HELICc2 K03722 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 439.0
TLS2_k127_5650684_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000004804 159.0
TLS2_k127_5650684_2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.0002986 49.0
TLS2_k127_5663979_0 Wzt C-terminal domain K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 315.0
TLS2_k127_5663979_1 ABC-2 type transporter K01992,K09690,K09691,K09692 - - 0.00000000000000000000000000000000000000000000002199 179.0
TLS2_k127_5663979_2 Glycosyl transferases group 1 - - - 0.0000000006462 68.0
TLS2_k127_5663979_3 O-Antigen ligase K18814 - - 0.000008863 59.0
TLS2_k127_5666315_0 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 380.0
TLS2_k127_5666315_1 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002325 267.0
TLS2_k127_5667299_0 Carboxypeptidase regulatory-like domain - - - 4.46e-319 1013.0
TLS2_k127_5667299_1 insulin processing K01292,K07752,K13022 GO:0002673,GO:0002682,GO:0002697,GO:0002920,GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009056,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010815,GO:0010817,GO:0012505,GO:0014070,GO:0016020,GO:0016485,GO:0016486,GO:0016787,GO:0017144,GO:0017171,GO:0019222,GO:0019538,GO:0030070,GO:0030141,GO:0030162,GO:0030449,GO:0031347,GO:0031410,GO:0031960,GO:0031982,GO:0032101,GO:0033993,GO:0034641,GO:0036477,GO:0042221,GO:0042445,GO:0042737,GO:0043025,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044297,GO:0044421,GO:0044424,GO:0044425,GO:0044444,GO:0044456,GO:0044459,GO:0044464,GO:0045202,GO:0048545,GO:0048583,GO:0050727,GO:0050776,GO:0050789,GO:0050896,GO:0051171,GO:0051246,GO:0051384,GO:0051604,GO:0060255,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070613,GO:0071704,GO:0071944,GO:0080090,GO:0080134,GO:0097060,GO:0097458,GO:0097708,GO:0098590,GO:0099503,GO:0140096,GO:1901142,GO:1901564,GO:1901565,GO:1901575,GO:1903317,GO:2000257 3.4.17.22,3.4.17.3 0.000000002502 64.0
TLS2_k127_5669005_0 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 533.0
TLS2_k127_5669005_1 Oxidoreductase molybdopterin binding domain K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005752 442.0
TLS2_k127_5669005_10 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000007406 69.0
TLS2_k127_5669005_2 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 433.0
TLS2_k127_5669005_3 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003436 372.0
TLS2_k127_5669005_4 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 335.0
TLS2_k127_5669005_5 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000002936 246.0
TLS2_k127_5669005_6 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000004213 230.0
TLS2_k127_5669005_7 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0000000000000000000000000000000000000000000000000000000000001381 218.0
TLS2_k127_5669005_8 Penicillinase repressor - - - 0.00000000000000000000000000002167 122.0
TLS2_k127_5669005_9 Histidine kinase-like ATPases - - - 0.00000000000000000000007338 113.0
TLS2_k127_5669098_0 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 320.0
TLS2_k127_5669098_1 Trimethylamine methyltransferase K14083 - 2.1.1.250 0.0000008227 55.0
TLS2_k127_5677294_0 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 7.519e-247 769.0
TLS2_k127_5677294_1 lactate racemase activity K22373 - 5.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 495.0
TLS2_k127_5677294_2 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000003844 269.0
TLS2_k127_5677294_3 KR domain K00046 - 1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000001177 233.0
TLS2_k127_5684894_0 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 501.0
TLS2_k127_5684894_1 Participates in transcription elongation, termination and antitermination - - - 0.000000001507 63.0
TLS2_k127_5687088_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000001499 107.0
TLS2_k127_5687088_1 ECF sigma factor K03088 - - 0.00000000000001208 80.0
TLS2_k127_5687088_2 Peptidase family S41 K03797 - 3.4.21.102 0.000000000006151 79.0
TLS2_k127_5696167_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.138e-262 832.0
TLS2_k127_5696167_1 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000003072 188.0
TLS2_k127_5696167_2 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000172 169.0
TLS2_k127_5696167_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000002762 75.0
TLS2_k127_5696167_4 - - - - 0.000000000006155 70.0
TLS2_k127_5696167_5 Putative zinc-finger - - - 0.00004794 53.0
TLS2_k127_5712126_0 Domain of Unknown Function (DUF1259) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 312.0
TLS2_k127_5712126_1 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000000000000000000001521 224.0
TLS2_k127_5712126_2 protocatechuate 3,4-dioxygenase activity - - - 0.00000000000000000000000004227 114.0
TLS2_k127_5712126_3 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000007023 90.0
TLS2_k127_5712126_4 Carbohydrate family 9 binding domain-like - - - 0.000003837 53.0
TLS2_k127_5735716_0 phosphoprotein phosphatase activity K01525 GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 321.0
TLS2_k127_5735716_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 308.0
TLS2_k127_5735716_2 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000003523 223.0
TLS2_k127_5735716_3 Domain of unknown function (DUF309) K09763 - - 0.000000000000000000000000000000000000000001731 161.0
TLS2_k127_575729_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 376.0
TLS2_k127_575729_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 307.0
TLS2_k127_575729_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000002091 59.0
TLS2_k127_5775063_0 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000191 259.0
TLS2_k127_5775063_1 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.000000000000000000000000000000000000000000000000003344 189.0
TLS2_k127_5775063_2 Protein involved in outer membrane biogenesis K07289,K07290 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - 0.0000000000000000000000000000002489 129.0
TLS2_k127_5780289_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 493.0
TLS2_k127_5780289_1 Glycosyl hydrolase family 65, N-terminal domain K15923 - 3.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 407.0
TLS2_k127_578859_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 1.238e-245 768.0
TLS2_k127_578859_1 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 443.0
TLS2_k127_578859_2 Esterase-like activity of phytase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008529 250.0
TLS2_k127_578859_3 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000004715 158.0
TLS2_k127_578859_4 Peptidase family M1 domain K01256 - 3.4.11.2 0.00000002714 59.0
TLS2_k127_5789094_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007506 567.0
TLS2_k127_5789094_1 Cupin superfamily (DUF985) K09705 - - 0.00000000000000000000000000000000000000000000002695 175.0
TLS2_k127_5789094_2 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit S4 paralog K04762 - - 0.000000000000001303 87.0
TLS2_k127_579739_0 beta-galactosidase activity - - - 3.541e-267 844.0
TLS2_k127_579739_1 PFAM aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 574.0
TLS2_k127_579739_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000913 207.0
TLS2_k127_579739_3 Histone deacetylase domain - - - 0.000000000000000000000000000008856 124.0
TLS2_k127_5805090_0 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000003934 240.0
TLS2_k127_5805090_1 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000005651 166.0
TLS2_k127_5805090_2 Histidine kinase - - - 0.0000000000000000000000000000000000000001772 168.0
TLS2_k127_5805090_3 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic K02051 - - 0.00000000000000000000000000000000000002415 156.0
TLS2_k127_5805090_4 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587 1.5.1.40 0.0000000000000000000000000000008696 130.0
TLS2_k127_5805090_5 - - - - 0.000000000000000000384 102.0
TLS2_k127_5805090_6 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000001111 98.0
TLS2_k127_5805090_7 SMART protein phosphatase 2C domain protein K07315 - 3.1.3.3 0.00000000000000001592 88.0
TLS2_k127_5805090_8 Tetratricopeptide repeat - - - 0.00003894 55.0
TLS2_k127_5807684_0 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007687 499.0
TLS2_k127_5807684_1 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006825 289.0
TLS2_k127_580846_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 421.0
TLS2_k127_580846_1 Carboxypeptidase regulatory-like domain - - - 0.000009576 56.0
TLS2_k127_5810021_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000003227 248.0
TLS2_k127_5810021_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.00000000000000000000004278 115.0
TLS2_k127_5820318_0 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004142 256.0
TLS2_k127_5820318_1 PFAM Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000003493 244.0
TLS2_k127_5820318_2 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000002609 214.0
TLS2_k127_5820318_3 O-methyltransferase, family 2 - - - 0.0000000000000000007872 89.0
TLS2_k127_5833328_0 PFAM Acetamidase Formamidase family K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 474.0
TLS2_k127_5833328_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000002013 96.0
TLS2_k127_5833328_2 - - - - 0.0000000001272 74.0
TLS2_k127_5835001_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 625.0
TLS2_k127_5835001_1 L-rhamnose-proton symport protein (RhaT) - - - 0.000000000000000000000000000000000000000000000000000000000000000001843 239.0
TLS2_k127_5835001_2 proline dipeptidase activity K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000082 220.0
TLS2_k127_584341_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 2.481e-227 720.0
TLS2_k127_584341_1 transferase activity, transferring glycosyl groups K16212 - 2.4.1.281 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 603.0
TLS2_k127_584341_2 Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) K16213 - 5.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 437.0
TLS2_k127_584341_3 Carbohydrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009268 315.0
TLS2_k127_584341_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001366 282.0
TLS2_k127_584341_5 Protein of unknown function (DUF1349) K09702 - - 0.0000000000000000000000000000000000000000000000000000002689 201.0
TLS2_k127_584341_6 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000005312 172.0
TLS2_k127_584341_7 ABC transporter K02003 - - 0.00000000000000000000000000000000000009949 144.0
TLS2_k127_584341_8 Protein of unknown function (DUF1579) - - - 0.00000000000000000000000321 111.0
TLS2_k127_5845295_0 elongation factor G K02355 - - 4.076e-228 727.0
TLS2_k127_5845295_1 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000001139 220.0
TLS2_k127_5845295_2 - - - - 0.0002231 46.0
TLS2_k127_5849841_0 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 598.0
TLS2_k127_5849841_1 PFAM chalcone and stilbene synthase domain protein K16167 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009982 398.0
TLS2_k127_5849841_2 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 309.0
TLS2_k127_5849841_3 PFAM Silent information regulator protein Sir2 K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003506 256.0
TLS2_k127_5849841_4 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000000000000000001444 184.0
TLS2_k127_5849841_5 Isoprenylcysteine carboxyl methyltransferase K16168 - - 0.0000000000000000000000000000000000000000000006372 173.0
TLS2_k127_5849841_6 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000326 130.0
TLS2_k127_5849841_7 TIGRFAM TonB K03832 - - 0.00000000000000000000000002416 119.0
TLS2_k127_5849841_8 EcsC protein family - - - 0.0000229 48.0
TLS2_k127_5866583_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000004675 91.0
TLS2_k127_5866583_1 nuclease activity - - - 0.000000004215 63.0
TLS2_k127_5866583_2 PFAM Transposase IS200 like K07491 - - 0.000005002 50.0
TLS2_k127_5884324_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 2.424e-241 760.0
TLS2_k127_5884324_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 360.0
TLS2_k127_5884324_2 outer membrane efflux protein - - - 0.000000000000000000000000000000000171 139.0
TLS2_k127_5889268_0 beta-galactosidase activity - - - 1.772e-203 640.0
TLS2_k127_5889268_1 Protein of unknown function, DUF481 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 366.0
TLS2_k127_5889268_2 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000006666 196.0
TLS2_k127_5889497_0 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K00333,K12142,K15830 GO:0003674,GO:0005488,GO:0016151,GO:0043167,GO:0043169,GO:0046872,GO:0046914 1.6.5.3 1.218e-245 769.0
TLS2_k127_5889497_1 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 364.0
TLS2_k127_5889497_2 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 340.0
TLS2_k127_5889497_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K12143,K15831 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006675 254.0
TLS2_k127_5889497_4 Belongs to the complex I 20 kDa subunit family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000028 235.0
TLS2_k127_5892569_0 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005537 374.0
TLS2_k127_5892569_1 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000003507 197.0
TLS2_k127_5892569_2 addiction module antidote protein, HigA family K21498 - - 0.0000000000000000000000000000001465 124.0
TLS2_k127_5892569_3 aspartic-type endopeptidase activity - - - 0.0000000000000000008157 98.0
TLS2_k127_5892569_4 LGFP repeat - - - 0.000001487 57.0
TLS2_k127_5900136_0 Tricorn protease homolog - - - 1.172e-232 732.0
TLS2_k127_5900136_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000001204 260.0
TLS2_k127_5900136_2 SMART Tetratricopeptide - - - 0.000000000000000007315 93.0
TLS2_k127_5900136_3 monooxygenase activity - - - 0.00003375 50.0
TLS2_k127_5905994_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 404.0
TLS2_k127_5905994_1 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 321.0
TLS2_k127_5905994_2 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000177 267.0
TLS2_k127_5905994_3 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002599 266.0
TLS2_k127_5906629_0 Domain of unknown function(DUF2779) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 353.0
TLS2_k127_5906629_1 WYL domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 304.0
TLS2_k127_5906629_2 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000002113 222.0
TLS2_k127_5906629_3 Mazg nucleotide pyrophosphohydrolase - - - 0.0000000000000000000000000000000001501 136.0
TLS2_k127_5906629_4 PFAM DNA alkylation repair enzyme - - - 0.000000000000000000007638 104.0
TLS2_k127_5906629_5 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000001721 68.0
TLS2_k127_5913296_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.602e-318 993.0
TLS2_k127_5913296_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.833e-226 706.0
TLS2_k127_5913296_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 429.0
TLS2_k127_5913296_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 409.0
TLS2_k127_5913296_4 Peptidase C26 K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001928 270.0
TLS2_k127_5913296_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000006414 263.0
TLS2_k127_5915102_0 Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 364.0
TLS2_k127_5915102_1 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007287 277.0
TLS2_k127_5915102_2 translation release factor activity K03265 - - 0.00000000000071 80.0
TLS2_k127_5915939_0 Aldo/keto reductase family K07079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 456.0
TLS2_k127_5915939_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 451.0
TLS2_k127_5915939_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 390.0
TLS2_k127_5915939_4 Transcriptional regulator, DeoR K02081 - - 0.00000000000000000000000000000000000000000000000000000000000000002802 234.0
TLS2_k127_5915939_5 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000002219 229.0
TLS2_k127_5915939_6 PFAM Sugar isomerase (SIS) K02082 - - 0.000000000000000000000000000000000000000000000000000000000000004804 231.0
TLS2_k127_5915939_7 protein trimerization - - - 0.00000000000000000000000000000000003274 139.0
TLS2_k127_5915939_8 xylan catabolic process - - - 0.00000000000000000000000000000000004091 144.0
TLS2_k127_5915939_9 Ankyrin repeat - - - 0.0001766 51.0
TLS2_k127_5922424_0 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 419.0
TLS2_k127_5922424_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 380.0
TLS2_k127_5922424_2 ATPase-coupled phosphate ion transmembrane transporter activity K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 354.0
TLS2_k127_5922424_3 TIGRFAM phosphate ABC transporter, inner membrane subunit PstC K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001785 274.0
TLS2_k127_5922424_4 DoxX K16937 - 1.8.5.2 0.00000004533 55.0
TLS2_k127_5926964_0 Heavy-metal-associated domain K17686 - 3.6.3.54 8.733e-223 710.0
TLS2_k127_5926964_1 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 593.0
TLS2_k127_5926964_10 COG0720 6-pyruvoyl-tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000003586 161.0
TLS2_k127_5926964_11 Thioredoxin-like - - - 0.00000000000000000000000000002698 127.0
TLS2_k127_5926964_2 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004944 494.0
TLS2_k127_5926964_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 441.0
TLS2_k127_5926964_4 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 408.0
TLS2_k127_5926964_5 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 351.0
TLS2_k127_5926964_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001186 271.0
TLS2_k127_5926964_7 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000003228 237.0
TLS2_k127_5926964_8 Major Facilitator Superfamily K08223 - - 0.000000000000000000000000000000000000000000001053 181.0
TLS2_k127_5926964_9 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000797 173.0
TLS2_k127_5933615_0 C-terminal region of aryl-sulfatase K01130 - 3.1.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 580.0
TLS2_k127_5933615_1 - - - - 0.000000000000000000000000000000000000000000000000006285 207.0
TLS2_k127_5933615_2 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000004096 182.0
TLS2_k127_5937803_0 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001364 272.0
TLS2_k127_5937803_1 Uncharacterised nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000005019 235.0
TLS2_k127_5937803_2 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000005866 222.0
TLS2_k127_5937803_3 glycosyltransferase 36 associated K00702,K13688 - 2.4.1.20 0.00000000000000000000000000000000000000000000001373 186.0
TLS2_k127_5937803_4 beta-lactamase - - - 0.00000000000000000006451 89.0
TLS2_k127_5945903_0 cheY-homologous receiver domain - - - 0.000000000000000000000000001159 118.0
TLS2_k127_5945903_1 response regulator K07684 - - 0.00000000000000001185 87.0
TLS2_k127_5945903_2 transcription factor binding - - - 0.00000000000007554 79.0
TLS2_k127_5950012_0 deaminated base DNA N-glycosylase activity K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002911 274.0
TLS2_k127_5952348_0 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000001711 208.0
TLS2_k127_5952348_1 Sulfatase - - - 0.0000000000000000000000000000000000000000000000002668 189.0
TLS2_k127_5955707_0 proline dipeptidase activity K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 383.0
TLS2_k127_5955707_1 cell redox homeostasis K00384,K12057,K12267,K21636 - 1.1.98.6,1.8.1.9,1.8.4.11,1.8.4.12 0.0000000000000000005632 100.0
TLS2_k127_5955707_2 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000585 47.0
TLS2_k127_5961962_0 nodulation K00612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003838 312.0
TLS2_k127_5961962_1 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 292.0
TLS2_k127_5961962_2 Carbamoyltransferase C-terminus K00612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002252 276.0
TLS2_k127_5961962_3 - - - - 0.00000000000000449 80.0
TLS2_k127_5961962_4 - - - - 0.000000000001284 71.0
TLS2_k127_5961962_5 Polysaccharide biosynthesis/export protein K01991 - - 0.0002758 45.0
TLS2_k127_597852_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 461.0
TLS2_k127_597852_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000003052 252.0
TLS2_k127_597852_2 TIGRFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000001418 246.0
TLS2_k127_597852_3 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000412 204.0
TLS2_k127_597852_4 Prephenate dehydrogenase K00210 - 1.3.1.12 0.00000000000000000000000000000000000000000002215 171.0
TLS2_k127_597852_5 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000000000007773 162.0
TLS2_k127_597852_6 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000002179 143.0
TLS2_k127_597852_7 Binds the 23S rRNA K02909 - - 0.00000000000000000000000000003435 117.0
TLS2_k127_597852_8 Carbohydrate family 9 binding domain-like - - - 0.000000000000000000000000000222 123.0
TLS2_k127_597852_9 von Willebrand factor (vWF) type A domain K07114 - - 0.000000001121 71.0
TLS2_k127_5991301_0 phosphorelay signal transduction system K02481,K07713,K07714 - - 7.819e-214 672.0
TLS2_k127_5991301_1 Polysulphide reductase, NrfD K00185 - - 3.821e-195 616.0
TLS2_k127_5991301_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002719 253.0
TLS2_k127_5991301_11 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002617 264.0
TLS2_k127_5991301_12 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000005618 231.0
TLS2_k127_5991301_13 electron transfer activity K08738 - - 0.000000000000000000000000000000000000000000000000000000000000005679 221.0
TLS2_k127_5991301_14 glycine decarboxylation via glycine cleavage system K02437 - - 0.00000000000000000000000000000000000000000000000000000000000008488 224.0
TLS2_k127_5991301_15 Ferredoxin K04755 - - 0.0000000000000000000000000000000000000000000000000000142 193.0
TLS2_k127_5991301_16 ApbE family - - - 0.0000000000000000000000000000000000000000000000000008068 196.0
TLS2_k127_5991301_17 metallopeptidase activity K06974 - - 0.0000000000000000000000000000000000000000015 160.0
TLS2_k127_5991301_18 E-Z type HEAT repeats - - - 0.0000000000000000000000000000000000000009171 169.0
TLS2_k127_5991301_19 O-Antigen ligase K18814 - - 0.0000000000000000000000000000000007649 145.0
TLS2_k127_5991301_2 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 601.0
TLS2_k127_5991301_20 RNA recognition motif - - - 0.000000000000000000000000001284 117.0
TLS2_k127_5991301_21 protein N-acetylglucosaminyltransferase activity - - - 0.000000000000001042 89.0
TLS2_k127_5991301_22 Peptidoglycan-binding domain 1 protein - - - 0.00000000008566 67.0
TLS2_k127_5991301_24 - - - - 0.0004509 46.0
TLS2_k127_5991301_3 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 518.0
TLS2_k127_5991301_4 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 383.0
TLS2_k127_5991301_5 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843,K02849 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 328.0
TLS2_k127_5991301_6 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 319.0
TLS2_k127_5991301_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005053 301.0
TLS2_k127_5991301_8 glycine decarboxylation via glycine cleavage system K02437 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006285 267.0
TLS2_k127_5991301_9 Biogenesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002223 254.0
TLS2_k127_5995538_0 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006866 263.0
TLS2_k127_5995538_1 Glycogen debranching enzyme N terminal - - - 0.000000000000000000000000000000000000000000000000000000001323 201.0
TLS2_k127_5995538_2 Domain of unknown function (DUF892) - - - 0.00000000000000000000000000000000000000000000601 172.0
TLS2_k127_5995538_3 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - 0.000000000000000000000000000000000002179 145.0
TLS2_k127_5995538_5 - - - - 0.000000000000421 70.0
TLS2_k127_5996316_0 Dehydrogenase E1 component K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 8.333e-237 750.0
TLS2_k127_5996316_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627,K00658,K09699 - 2.3.1.12,2.3.1.168,2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 393.0
TLS2_k127_5996316_2 Dehydrogenase E1 component K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000001312 251.0
TLS2_k127_5996316_3 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000000000000000000000000000000000000001219 205.0
TLS2_k127_5996316_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.000000000000000003947 87.0
TLS2_k127_6017740_0 beta-galactosidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 467.0
TLS2_k127_6017740_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - - 0.00000000000000000001075 104.0
TLS2_k127_6017740_2 Uroporphyrinogen decarboxylase (URO-D) - - - 0.00000000000000000001132 104.0
TLS2_k127_6027319_0 Glycosyl hydrolases family 2 - - - 3.861e-237 748.0
TLS2_k127_6032618_0 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 553.0
TLS2_k127_6032618_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 475.0
TLS2_k127_6032618_2 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 297.0
TLS2_k127_6032618_3 Peptidase family M54 K06974 - - 0.000000000000000000000000000000000000000003371 161.0
TLS2_k127_6038755_0 PFAM Cytochrome C assembly protein K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 386.0
TLS2_k127_6038755_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007784 311.0
TLS2_k127_6038755_2 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000000000000000000000000000000001224 146.0
TLS2_k127_6048611_0 ACT domain protein K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.000000000000000000000000000000001529 138.0
TLS2_k127_6048611_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000004632 117.0
TLS2_k127_6048611_2 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000000000000000002046 87.0
TLS2_k127_6048611_4 - - - - 0.0000000002611 73.0
TLS2_k127_6048611_5 Domain of unknown function (DUF4158) - - - 0.000000009088 59.0
TLS2_k127_6057850_0 Belongs to the xylose isomerase family K01805 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008048 472.0
TLS2_k127_6057850_1 PFAM Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 346.0
TLS2_k127_6057850_2 TonB dependent receptor K16089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006188 278.0
TLS2_k127_6057850_3 heme-binding domain, Pirellula Verrucomicrobium type - - - 0.0000000000000000000000000000000002749 143.0
TLS2_k127_6057850_4 Redoxin - - - 0.00000000000000000000000005673 114.0
TLS2_k127_6057850_5 Aldo keto reductase - - - 0.00000007591 57.0
TLS2_k127_6060707_0 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 556.0
TLS2_k127_6060707_1 Belongs to the glycosyl hydrolase 43 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009899 275.0
TLS2_k127_6060707_2 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000001519 193.0
TLS2_k127_6060707_3 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000000004456 171.0
TLS2_k127_6064147_0 Glucose inhibited division protein A K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1086.0
TLS2_k127_6064147_1 Heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004817 331.0
TLS2_k127_6064147_2 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003068 247.0
TLS2_k127_6064147_3 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000005695 201.0
TLS2_k127_6064147_4 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000003788 198.0
TLS2_k127_6064147_5 nucleotidyltransferase activity K00984,K19279 - 2.7.7.47 0.000000000000000000000000000000000000000000000000000009709 197.0
TLS2_k127_6064147_6 Methanol dehydrogenase K06872 - - 0.00000000000000002308 87.0
TLS2_k127_6065525_0 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006839 434.0
TLS2_k127_6065525_1 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000001597 205.0
TLS2_k127_6065525_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000444 68.0
TLS2_k127_6066258_0 metallopeptidase activity K01179 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0016052,GO:0016787,GO:0016798,GO:0033946,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0052736,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.4 6.283e-251 784.0
TLS2_k127_6066258_1 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 409.0
TLS2_k127_6066258_2 Alpha-L-rhamnosidase N-terminal domain K05989 - 3.2.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 349.0
TLS2_k127_6066258_3 Belongs to the glycosyl hydrolase 26 family K01218 - 3.2.1.78 0.000000000000000000002359 95.0
TLS2_k127_6069208_0 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000004286 131.0
TLS2_k127_6069208_1 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.00000000007971 75.0
TLS2_k127_6076755_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 434.0
TLS2_k127_6076755_1 COG COG0846 NAD-dependent protein deacetylases, SIR2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 346.0
TLS2_k127_6076755_2 Methane oxygenase PmoA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 300.0
TLS2_k127_6076755_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000001654 208.0
TLS2_k127_6076755_4 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000009833 209.0
TLS2_k127_6076755_5 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000000000000000000000003572 185.0
TLS2_k127_6076755_6 Domain of unknown function (DUF378) K09779 - - 0.00000000000003502 72.0
TLS2_k127_607700_0 Uncharacterized conserved protein (DUF2075) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 354.0
TLS2_k127_607700_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000001326 131.0
TLS2_k127_607700_2 Uncharacterised protein family (UPF0158) - - - 0.00000000000000000000000000009302 128.0
TLS2_k127_607700_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000003347 112.0
TLS2_k127_607700_5 - K21495 - - 0.000000001221 63.0
TLS2_k127_6078779_0 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007428 344.0
TLS2_k127_6078779_1 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008516 256.0
TLS2_k127_6078779_2 FCD - - - 0.00000000000000000000000000000004561 133.0
TLS2_k127_6078779_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000003032 71.0
TLS2_k127_6078883_0 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002784 393.0
TLS2_k127_6078883_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 339.0
TLS2_k127_6078883_2 Methane oxygenase PmoA - - - 0.00000000003941 67.0
TLS2_k127_6085779_0 PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 473.0
TLS2_k127_6085779_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K04085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 447.0
TLS2_k127_6085779_2 Lipocalin / cytosolic fatty-acid binding protein family K03098 - - 0.000000000000000000000000000000000000000000000000000000387 201.0
TLS2_k127_6086315_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K09181 - - 4.7e-322 997.0
TLS2_k127_6086315_1 PFAM HypF finger K04656 - - 1.127e-286 899.0
TLS2_k127_6086315_2 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 553.0
TLS2_k127_6086315_3 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.0000000000000000000000123 106.0
TLS2_k127_6086315_4 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000002608 91.0
TLS2_k127_6087303_0 beta-galactosidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 355.0
TLS2_k127_6087303_1 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 296.0
TLS2_k127_6093190_0 COG1233 Phytoene dehydrogenase and related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 572.0
TLS2_k127_6093190_1 PFAM FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 466.0
TLS2_k127_6105506_0 HI0933-like protein K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 460.0
TLS2_k127_6105506_1 Diacylglycerol kinase catalytic domain (presumed) K07029 GO:0003674,GO:0003824,GO:0004143,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001394 282.0
TLS2_k127_6105506_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000001541 150.0
TLS2_k127_6105506_3 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000004157 95.0
TLS2_k127_6118698_0 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000001138 245.0
TLS2_k127_6118698_1 NIPSNAP family containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000005313 225.0
TLS2_k127_6118698_2 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000000000000000000000000000003068 198.0
TLS2_k127_6118698_3 oxidoreductase activity - - - 0.000001436 56.0
TLS2_k127_612114_0 Catalase K07217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 366.0
TLS2_k127_612114_1 Asparaginase K01424 - 3.5.1.1 0.000000000000000000000000000000000000000000008989 171.0
TLS2_k127_6127299_0 ASPIC and UnbV - - - 3.739e-210 664.0
TLS2_k127_6127299_1 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 489.0
TLS2_k127_6127299_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 431.0
TLS2_k127_6127299_3 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 397.0
TLS2_k127_6127299_4 acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 375.0
TLS2_k127_6127299_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000425 167.0
TLS2_k127_6127299_6 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000000000000000007371 143.0
TLS2_k127_6127299_7 Methylates ribosomal protein L11 K02687 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000002617 140.0
TLS2_k127_6127299_8 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000001567 81.0
TLS2_k127_612935_0 response regulator K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 361.0
TLS2_k127_612935_1 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002617 286.0
TLS2_k127_612935_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000001177 213.0
TLS2_k127_612935_3 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000005185 141.0
TLS2_k127_6166422_0 Domain of unknown function (DUF3520) K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 577.0
TLS2_k127_6166422_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004551 508.0
TLS2_k127_6166422_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 453.0
TLS2_k127_6166422_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007155 417.0
TLS2_k127_6166422_4 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000341 240.0
TLS2_k127_6171443_0 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004307 282.0
TLS2_k127_6171443_1 ferroxidase activity K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.00000000000000000000000000000000000000000000000001122 184.0
TLS2_k127_6171443_2 Domain of unknown function (DUF4440) - - - 0.000000000764 66.0
TLS2_k127_6171443_3 capsule polysaccharide biosynthetic process - - - 0.00002301 53.0
TLS2_k127_6180938_0 Transketolase, pyrimidine binding domain K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 357.0
TLS2_k127_6180938_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 305.0
TLS2_k127_6180938_2 mannitol metabolic process K00009 - 1.1.1.17 0.00000000000000000000000000000000000000000000000000000000000002453 224.0
TLS2_k127_6180938_3 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.00000000000000000000000000000003055 141.0
TLS2_k127_6190078_0 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000005481 211.0
TLS2_k127_6190078_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000003344 134.0
TLS2_k127_6190078_2 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000004362 106.0
TLS2_k127_6190078_3 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000001536 96.0
TLS2_k127_6190078_4 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.000000000000000007112 96.0
TLS2_k127_6190078_5 - - - - 0.0000000000002782 72.0
TLS2_k127_6190078_6 Putative zinc-finger - - - 0.000009817 54.0
TLS2_k127_6194874_0 Sodium:sulfate symporter transmembrane region K03319,K09477,K11106,K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005148 563.0
TLS2_k127_6194874_1 dead DEAH box helicase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 509.0
TLS2_k127_6194874_2 Peptidase dimerisation domain K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 467.0
TLS2_k127_6194874_3 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 433.0
TLS2_k127_6194874_4 NADPH:quinone reductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008497 363.0
TLS2_k127_6194874_5 Serine acetyltransferase K00640 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 329.0
TLS2_k127_6194874_6 Trehalose utilisation - - - 0.0000000000000000000000000000000000000000000000000000000000007975 220.0
TLS2_k127_6194874_7 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000000008328 205.0
TLS2_k127_6194874_8 - - - - 0.000000000000000000003797 95.0
TLS2_k127_6207505_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 4.034e-282 876.0
TLS2_k127_6210514_0 hydrolase family 10 K01181 - 3.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 443.0
TLS2_k127_6210514_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 312.0
TLS2_k127_6210514_2 pyrroloquinoline quinone binding K01206 - 3.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000002253 245.0
TLS2_k127_6210514_3 DinB family - - - 0.00000000000000000000000000000000000000000000000000000000000005741 217.0
TLS2_k127_6210514_4 IMG reference gene - - - 0.000000000000000000000001737 115.0
TLS2_k127_6210514_5 eRF1 domain 3 - - - 0.000000000000000007567 95.0
TLS2_k127_6210514_6 Protein of unknown function (DUF2795) - - - 0.00000000000000001248 83.0
TLS2_k127_6210514_7 COG3119 Arylsulfatase A - - - 0.000000000000001567 84.0
TLS2_k127_6211916_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 353.0
TLS2_k127_6211916_1 SIS domain K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001676 284.0
TLS2_k127_6211916_2 membrane - - - 0.0005704 48.0
TLS2_k127_6215503_0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 8.552e-280 881.0
TLS2_k127_6215503_1 Glycosyl hydrolase family 65, N-terminal domain K15923 - 3.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 554.0
TLS2_k127_6215503_2 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000009341 209.0
TLS2_k127_6215879_0 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 2.112e-295 934.0
TLS2_k127_6215879_1 Sugar transport protein K05340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 438.0
TLS2_k127_6215879_2 ADP-ribosylglycohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 425.0
TLS2_k127_6215879_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 381.0
TLS2_k127_6215879_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009232 337.0
TLS2_k127_6215879_5 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 309.0
TLS2_k127_6215879_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000002279 260.0
TLS2_k127_6215879_7 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.00000000000000000000000000000000000000000000000263 181.0
TLS2_k127_6240638_0 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 419.0
TLS2_k127_6240638_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000006002 181.0
TLS2_k127_6240638_2 - - - - 0.000000000000002017 83.0
TLS2_k127_6242007_0 TonB-dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 331.0
TLS2_k127_6250790_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 3.868e-256 803.0
TLS2_k127_6250790_1 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 1.635e-206 655.0
TLS2_k127_6250790_2 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 441.0
TLS2_k127_6250790_3 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000007771 185.0
TLS2_k127_6250790_4 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200 0.0000000000000000000000000000000000104 145.0
TLS2_k127_6250790_5 TIGRFAM TrpR like protein, YerC YecD - - - 0.00000000000000000000001263 104.0
TLS2_k127_6256503_0 Short chain dehydrogenase - - - 1.166e-198 641.0
TLS2_k127_6256503_1 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 353.0
TLS2_k127_6256503_2 Cys-tRNA(Pro) hydrolase activity K03976 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000001339 198.0
TLS2_k127_6256503_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000002082 121.0
TLS2_k127_6256503_4 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000001181 99.0
TLS2_k127_6257002_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 4.182e-272 860.0
TLS2_k127_6257002_1 Beta-eliminating lyase K01667 - 4.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 351.0
TLS2_k127_6257002_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001105 289.0
TLS2_k127_6257002_3 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000002326 197.0
TLS2_k127_6257002_4 RESPONSE REGULATOR receiver - - - 0.0000000000000009592 89.0
TLS2_k127_6257002_5 Heavy-metal-associated domain - - - 0.00000000000002549 78.0
TLS2_k127_6273221_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 571.0
TLS2_k127_6273221_1 Cellulase N-terminal ig-like domain - - - 0.0000000000000000000000000009355 112.0
TLS2_k127_6273221_2 COG1566 Multidrug resistance efflux pump K03543 - - 0.000000002402 68.0
TLS2_k127_6275795_0 Glycosyl hydrolases family 2, TIM barrel domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004155 406.0
TLS2_k127_6285830_0 Methionine synthase II (cobalamin-independent) K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 346.0
TLS2_k127_6285830_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000003401 97.0
TLS2_k127_6304573_0 Hypothetical glycosyl hydrolase 6 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 468.0
TLS2_k127_6304573_1 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007832 250.0
TLS2_k127_6314696_0 Protein conserved in bacteria K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 436.0
TLS2_k127_6314696_1 Protein of unknown function (DUF3641) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 338.0
TLS2_k127_6314696_2 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000001188 218.0
TLS2_k127_6321319_0 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.0000000000000000000000000002801 123.0
TLS2_k127_6321319_1 Transglutaminase/protease-like homologues - - - 0.00000004421 66.0
TLS2_k127_6331258_0 SMP-30 Gluconolaconase LRE-like K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 380.0
TLS2_k127_6331258_1 PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007391 310.0
TLS2_k127_6331258_2 Putative esterase K07017 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007329 273.0
TLS2_k127_6331258_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000002637 246.0
TLS2_k127_6340766_0 Peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 415.0
TLS2_k127_6340766_1 Neutral alkaline nonlysosomal ceramidase - - - 0.0000000000007698 78.0
TLS2_k127_6356227_0 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 629.0
TLS2_k127_6356227_1 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01761 - 4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008235 599.0
TLS2_k127_6366903_0 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009678 366.0
TLS2_k127_6366903_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 324.0
TLS2_k127_637095_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000001732 222.0
TLS2_k127_637095_1 Periplasmic or secreted lipoprotein - - - 0.0000013 58.0
TLS2_k127_637835_0 Belongs to the glycosyl hydrolase 32 family - - - 0.00000000000000000000000000000000000000000000001336 190.0
TLS2_k127_637835_1 BNR repeat-like domain - - - 0.0000000000000000000000000000000000001755 153.0
TLS2_k127_637835_2 PFAM glucosamine galactosamine-6-phosphate isomerase K02564 - 3.5.99.6 0.00001025 51.0
TLS2_k127_6425390_0 MotA TolQ ExbB proton channel K03561,K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 291.0
TLS2_k127_6425390_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002592 267.0
TLS2_k127_6425390_2 TIGRFAM TonB family K03832 - - 0.00000000000000000000000000000000000000000000000000001132 198.0
TLS2_k127_6425390_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000003452 155.0
TLS2_k127_6425390_4 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000000000000000000000000002053 128.0
TLS2_k127_6425390_5 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.00000000000000000000000001804 113.0
TLS2_k127_6427954_0 May be involved in recombinational repair of damaged DNA K03631,K13582 GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000008583 247.0
TLS2_k127_6427954_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000004457 246.0
TLS2_k127_6428142_0 S-adenosylmethionine synthetase, C-terminal domain K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 539.0
TLS2_k127_6428142_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 537.0
TLS2_k127_6428142_2 argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 416.0
TLS2_k127_6428142_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 305.0
TLS2_k127_6428142_4 Regulates arginine biosynthesis genes K03402 - - 0.0000000000000000000001027 104.0
TLS2_k127_6432407_0 Trehalose utilisation - - - 0.0000000000000000000000000000000000000000000000000000000000000005878 228.0
TLS2_k127_6432407_1 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000001678 196.0
TLS2_k127_6432407_2 hyperosmotic response - - - 0.00000000000000000000000000000000000000003123 160.0
TLS2_k127_6432407_3 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000004671 108.0
TLS2_k127_6432407_4 DoxX K16937 - 1.8.5.2 0.00000000000000000000002659 114.0
TLS2_k127_6434514_0 ABC transporter K06020 - 3.6.3.25 9.972e-311 955.0
TLS2_k127_6434514_1 dTDP-4-dehydrorhamnose reductase activity K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000002299 171.0
TLS2_k127_6440060_0 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 359.0
TLS2_k127_6440060_1 TonB dependent receptor - - - 0.0000000000000000000000000000000000000001284 152.0
TLS2_k127_6440060_2 Sugar-specific transcriptional regulator TrmB - - - 0.0000000000000000000000000000003966 128.0
TLS2_k127_6440060_3 SnoaL-like domain - - - 0.000000000000000000000000005509 119.0
TLS2_k127_6440060_4 - - - - 0.00000001881 57.0
TLS2_k127_644458_0 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 572.0
TLS2_k127_644458_1 Aldo Keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006274 302.0
TLS2_k127_644458_2 Fumarylacetoacetate (FAA) hydrolase family K14259 - 4.2.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000001414 267.0
TLS2_k127_6455447_0 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 402.0
TLS2_k127_6455447_1 Band 7 protein K07192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000896 292.0
TLS2_k127_6455447_2 Maf-like protein K06287 GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0032506,GO:0044085,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0090529,GO:1902410,GO:1903047 - 0.0000000000000000000000000000000000000000000004847 174.0
TLS2_k127_6455447_3 Acetolactate synthase small K01653 - 2.2.1.6 0.0000000000000000000000000000000000007821 141.0
TLS2_k127_6455447_4 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 0.000000000000000000009948 92.0
TLS2_k127_646656_0 gluconolactonase activity K07004,K14274 - - 0.00000000000000000000000000000000000000000000000000000007439 221.0
TLS2_k127_646656_1 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000003979 184.0
TLS2_k127_646656_2 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.000000000000000000000000000000000000000000002576 188.0
TLS2_k127_646656_3 PFAM IS1 transposase K07480 - - 0.00000000000000001523 89.0
TLS2_k127_646656_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000008884 59.0
TLS2_k127_646656_5 Endonuclease Exonuclease Phosphatase - - - 0.00006458 56.0
TLS2_k127_6468845_0 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 5.041e-196 621.0
TLS2_k127_6468845_1 Major facilitator Superfamily K03292,K16248 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009156 423.0
TLS2_k127_6478434_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 3.551e-232 730.0
TLS2_k127_6478434_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000001173 176.0
TLS2_k127_6478434_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000000000000000000284 124.0
TLS2_k127_6478434_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000001651 66.0
TLS2_k127_6480952_0 PFAM oxidoreductase - - - 7.706e-196 616.0
TLS2_k127_6480952_1 PFAM conserved K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 341.0
TLS2_k127_6480952_2 tRNA pseudouridine synthase activity K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 306.0
TLS2_k127_6480952_3 TGS domain K06944 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007393 269.0
TLS2_k127_6480952_4 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000004365 256.0
TLS2_k127_6480952_5 Predicted membrane protein (DUF2157) - - - 0.0000000000000000000000000000000000000000000000000000000000001238 231.0
TLS2_k127_6480952_6 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000002935 128.0
TLS2_k127_6480952_7 GDYXXLXY protein - - - 0.000000000000000000000000000001714 130.0
TLS2_k127_6480952_8 methyltransferase K16215 - 2.1.1.243 0.00000000000885 77.0
TLS2_k127_6480952_9 COG0526 Thiol-disulfide isomerase and thioredoxins K03672 - 1.8.1.8 0.0000009366 51.0
TLS2_k127_6512501_0 TonB-dependent Receptor Plug Domain - - - 8.542e-218 719.0
TLS2_k127_6512501_1 Zinc-binding dehydrogenase K00008 - 1.1.1.14 3.387e-196 619.0
TLS2_k127_6512501_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 310.0
TLS2_k127_6512501_3 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 298.0
TLS2_k127_6512501_4 YwiC-like protein - - - 0.000000000141 71.0
TLS2_k127_6512501_5 ASPIC and UnbV - - - 0.0000000006856 66.0
TLS2_k127_6526825_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 523.0
TLS2_k127_6526825_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000007855 161.0
TLS2_k127_6535348_0 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 382.0
TLS2_k127_6535348_1 - - - - 0.000000000000000000000000000000000000001055 166.0
TLS2_k127_6543129_0 Beta-galactosidase trimerisation domain K12308 - 3.2.1.23 4.363e-279 877.0
TLS2_k127_6543129_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 436.0
TLS2_k127_6543129_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 425.0
TLS2_k127_6543129_3 Belongs to the pseudouridine synthase RluA family K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000002034 196.0
TLS2_k127_6543129_4 Protein of unknown function, DUF393 - - - 0.00000000000000000000000000000000000001788 148.0
TLS2_k127_6543129_5 Bacterial PH domain K08981 - - 0.0000000000000000000000000000008229 138.0
TLS2_k127_6543129_6 Bacterial PH domain K09167 - - 0.000000000000000000004511 101.0
TLS2_k127_6543129_7 Calcineurin-like phosphoesterase - - - 0.0004679 46.0
TLS2_k127_655018_0 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000000000000000000000000000004667 199.0
TLS2_k127_655018_1 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.000000000000000000000000000000002799 136.0
TLS2_k127_655018_2 - - - - 0.0000000000002627 79.0
TLS2_k127_6554896_0 Peptidase M56 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 299.0
TLS2_k127_6554896_1 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000001702 250.0
TLS2_k127_6554896_2 helix_turn_helix isocitrate lyase regulation K13641 - - 0.0000000000000000000000000000000000000001125 162.0
TLS2_k127_6558496_0 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 461.0
TLS2_k127_6558496_1 Transport permease protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 375.0
TLS2_k127_6558496_2 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 359.0
TLS2_k127_6558496_3 Glycosyl hydrolase family 26 K01218 - 3.2.1.78 0.000000003767 59.0
TLS2_k127_6558496_4 iduronate-2-sulfatase activity K01136 GO:0000323,GO:0003674,GO:0003824,GO:0004423,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005775,GO:0006022,GO:0006026,GO:0006027,GO:0006029,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008484,GO:0009056,GO:0009057,GO:0009100,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030203,GO:0030204,GO:0030207,GO:0031974,GO:0043170,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044273,GO:0044281,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0050654,GO:0070013,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903510 3.1.6.13 0.00000001414 59.0
TLS2_k127_6559092_0 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006436 587.0
TLS2_k127_6559092_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008548 247.0
TLS2_k127_6559092_2 isomerase activity K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000122 247.0
TLS2_k127_6559092_3 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000005861 205.0
TLS2_k127_6563468_0 Manganese containing catalase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 356.0
TLS2_k127_6563468_1 Domain of unknown function (DUF4185) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 337.0
TLS2_k127_6563468_2 Fungalysin metallopeptidase (M36) - - - 0.000000000000000000000000000000000003788 158.0
TLS2_k127_6563468_3 PA14 domain - - - 0.0000000802 66.0
TLS2_k127_6566299_0 DJ-1/PfpI family K03152,K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000001403 250.0
TLS2_k127_6566299_1 Belongs to the RbsD FucU family K02431 GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0005996,GO:0006004,GO:0008150,GO:0008152,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0030246,GO:0036094,GO:0042806,GO:0044238,GO:0044281,GO:0048029,GO:0071704 5.1.3.29 0.000000000000000000000000000000000000000000000000000000000001078 216.0
TLS2_k127_6566299_2 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000381 161.0
TLS2_k127_6566299_3 O-methyltransferase K00588 - 2.1.1.104 0.00000001368 58.0
TLS2_k127_6573153_0 Uncharacterized protein family (UPF0051) K09014 - - 5.674e-265 820.0
TLS2_k127_6573153_1 FeS assembly protein SufD K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 396.0
TLS2_k127_6573153_2 TIGRFAM FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 385.0
TLS2_k127_6573153_3 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 316.0
TLS2_k127_6573153_4 transcriptional regulator, Rrf2 family - - - 0.000000000000000000000000000000000002818 144.0
TLS2_k127_6573153_5 oxidoreductase activity K12511 - - 0.000000000000000000000000000000002583 143.0
TLS2_k127_6573153_6 - - - - 0.000000000000000000000005605 104.0
TLS2_k127_6580493_0 FAD linked oxidases, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001978 230.0
TLS2_k127_6580493_1 Pkd domain containing protein - - - 0.0000000004297 70.0
TLS2_k127_6589236_0 Glycosyl hydrolase family 63 C-terminal domain - - - 0.0 1033.0
TLS2_k127_6589236_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00520 - 1.16.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 556.0
TLS2_k127_6589236_2 KaiC K08482 - - 0.000000000000000000000000000000009957 130.0
TLS2_k127_6589236_3 Transmembrane anti-sigma factor - - - 0.000000000000000000000004361 103.0
TLS2_k127_6593930_0 PFAM oxidoreductase - - - 7.763e-198 624.0
TLS2_k127_6593930_1 cell wall glycoprotein biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 564.0
TLS2_k127_6593930_2 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 384.0
TLS2_k127_6593930_3 Periplasmic binding protein LacI transcriptional regulator K01775,K02529,K05499 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 306.0
TLS2_k127_6593930_4 E-Z type HEAT repeats - - - 0.000000000000001572 85.0
TLS2_k127_659453_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008935 407.0
TLS2_k127_659453_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000001336 147.0
TLS2_k127_659742_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006527 488.0
TLS2_k127_659742_1 NADH dehydrogenase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 407.0
TLS2_k127_659742_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639,K20967 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 324.0
TLS2_k127_659742_3 Divalent cation transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000009002 202.0
TLS2_k127_659742_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000643 191.0
TLS2_k127_659742_5 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000001555 173.0
TLS2_k127_659742_6 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000002879 154.0
TLS2_k127_659742_7 Protein of unknown function (DUF465) - - - 0.000001625 53.0
TLS2_k127_6606973_0 PFAM Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008717 311.0
TLS2_k127_6606973_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000007005 244.0
TLS2_k127_6606973_2 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.0000000000000000000000000000000000001202 144.0
TLS2_k127_663547_0 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001345 267.0
TLS2_k127_663547_2 ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000000000000000000000001557 198.0
TLS2_k127_663547_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000427 180.0
TLS2_k127_663547_4 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000004059 159.0
TLS2_k127_663547_5 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000004663 136.0
TLS2_k127_663678_0 - - - - 3.721e-200 638.0
TLS2_k127_663678_1 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 467.0
TLS2_k127_663678_2 Domain of unknown function (DUF4432) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009989 452.0
TLS2_k127_663678_3 Solute carrier family 35 - - - 0.00000000000002295 84.0
TLS2_k127_663678_4 Protein of unknown function (DUF1284) K09706 - - 0.0001702 53.0
TLS2_k127_6648762_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 423.0
TLS2_k127_6648762_1 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000002358 208.0
TLS2_k127_6653838_0 Peptidase M16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 350.0
TLS2_k127_6653838_1 Aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 303.0
TLS2_k127_6655872_0 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 480.0
TLS2_k127_6655872_1 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 471.0
TLS2_k127_6655872_2 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000000000007356 145.0
TLS2_k127_6667654_0 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000539 217.0
TLS2_k127_6667654_1 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000004225 194.0
TLS2_k127_6667654_2 PSP1 C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000002294 174.0
TLS2_k127_6667654_3 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000003329 168.0
TLS2_k127_6667654_4 DUF167 K09131 - - 0.0000002242 56.0
TLS2_k127_6667656_0 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004262 328.0
TLS2_k127_6667656_1 PFAM aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003033 282.0
TLS2_k127_6667656_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000002958 257.0
TLS2_k127_6667656_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000007303 149.0
TLS2_k127_6672045_0 Major facilitator superfamily K02429 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 549.0
TLS2_k127_6676537_0 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006552 467.0
TLS2_k127_6676537_1 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 414.0
TLS2_k127_6676537_2 MacB-like periplasmic core domain - - - 0.00007901 46.0
TLS2_k127_6681773_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07714,K19641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 390.0
TLS2_k127_6681773_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006964 336.0
TLS2_k127_6681773_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009155 327.0
TLS2_k127_6681773_3 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001637 263.0
TLS2_k127_6681773_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000004454 126.0
TLS2_k127_6684760_0 CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.0 1592.0
TLS2_k127_6684760_1 4 iron, 4 sulfur cluster binding - - - 5.332e-241 758.0
TLS2_k127_6684760_3 [glutamate-ammonia-ligase] adenylyltransferase activity K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 0.00000002373 60.0
TLS2_k127_6694939_0 transport - - - 0.0 1099.0
TLS2_k127_6694939_1 UTP--glucose-1-phosphate uridylyltransferase - - - 2.852e-266 832.0
TLS2_k127_6694939_2 Sodium:alanine symporter family K03310 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 426.0
TLS2_k127_6694939_3 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 333.0
TLS2_k127_6694939_4 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008011 327.0
TLS2_k127_6694939_5 Di-glucose binding within endoplasmic reticulum - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 324.0
TLS2_k127_6694939_6 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005368 288.0
TLS2_k127_6694939_7 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002515 256.0
TLS2_k127_6697793_0 6-phosphogluconolactonase activity - - - 2.03e-264 840.0
TLS2_k127_6697793_1 methyltransferase activity K21310 - 2.1.1.334 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 327.0
TLS2_k127_6714_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 327.0
TLS2_k127_6714_1 Phosphomethylpyrimidine kinase K00868,K00941,K03147,K21219 GO:0008150,GO:0040007 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005848 274.0
TLS2_k127_6714_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000001183 266.0
TLS2_k127_6714_3 TIGRFAM ROK family protein K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000005958 263.0
TLS2_k127_6714_4 permease - - - 0.0000000000000000000000000000000000000000000000000754 191.0
TLS2_k127_6714_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000006787 89.0
TLS2_k127_6714_6 YtxH-like protein - - - 0.00000000003634 68.0
TLS2_k127_6714_7 - - - - 0.00000000007909 69.0
TLS2_k127_6723690_0 TIGRFAM tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006623 418.0
TLS2_k127_6723690_1 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000007509 192.0
TLS2_k127_6723690_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000003479 189.0
TLS2_k127_6723690_3 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000001909 174.0
TLS2_k127_6723690_4 Peptidase M50 - - - 0.0000000000000000000003893 100.0
TLS2_k127_6730438_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 9.61e-221 701.0
TLS2_k127_6730438_1 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000001467 261.0
TLS2_k127_6730438_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000001526 203.0
TLS2_k127_6730438_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000003375 189.0
TLS2_k127_6730438_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000001178 134.0
TLS2_k127_6730438_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000005795 113.0
TLS2_k127_6730438_6 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000004699 91.0
TLS2_k127_6730438_7 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000003525 77.0
TLS2_k127_673387_0 3-isopropylmalate dehydratase activity K01703 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 1.611e-232 727.0
TLS2_k127_673387_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.011e-194 619.0
TLS2_k127_673387_2 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 352.0
TLS2_k127_673387_3 Aconitase C-terminal domain K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 305.0
TLS2_k127_673387_4 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000005789 250.0
TLS2_k127_6741750_0 symporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 511.0
TLS2_k127_6741750_1 Trehalose utilisation K09992 - - 0.00000001088 68.0
TLS2_k127_6744941_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 360.0
TLS2_k127_6744941_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006942 257.0
TLS2_k127_6744941_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000002752 211.0
TLS2_k127_6744941_3 Protein conserved in bacteria K07011 - - 0.0000000000000000000000000000000000000000000000000000003019 199.0
TLS2_k127_6744941_4 Histidine kinase K13040 - 2.7.13.3 0.00000000000000000000000000000000000000000000001197 186.0
TLS2_k127_6744941_5 - - - - 0.00000000000000000000000000000000000003554 154.0
TLS2_k127_6744941_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000007141 139.0
TLS2_k127_6744941_7 GYD domain - - - 0.00000000000000000000000000004441 119.0
TLS2_k127_6744941_8 - - - - 0.0000000000000000004961 87.0
TLS2_k127_6744941_9 Parallel beta-helix repeats - - - 0.000000002332 61.0
TLS2_k127_6745743_0 DNA-binding transcription factor activity K02316,K04096,K20421 - 2.1.1.303 0.000000000000000000000000000000000000000000000000000000000001028 226.0
TLS2_k127_6745743_1 Transcriptional regulator - - - 0.0000000000125 68.0
TLS2_k127_6745743_2 DNA excision - - - 0.0009642 46.0
TLS2_k127_6755227_0 PFAM GlcNAc-PI de-N-acetylase - - - 5.664e-253 804.0
TLS2_k127_6755227_1 Sodium:solute symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 568.0
TLS2_k127_6755227_2 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000007222 215.0
TLS2_k127_6755227_3 Belongs to the LDH2 MDH2 oxidoreductase family K13609 - 1.5.1.21 0.000000000000000000000000000000000000000000000000000000006911 213.0
TLS2_k127_6755227_4 TPR Domain containing protein K12600 - - 0.00000000001663 75.0
TLS2_k127_6762743_0 amine dehydrogenase activity - - - 2.874e-255 795.0
TLS2_k127_6762743_1 Putative cyclase K07130 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 304.0
TLS2_k127_6762743_2 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001069 283.0
TLS2_k127_6764263_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000189 149.0
TLS2_k127_6764263_1 TLC ATP/ADP transporter K03301 - - 0.000000000000000000000000000000000002529 160.0
TLS2_k127_676588_0 Belongs to the CarB family K01955 - 6.3.5.5 1.396e-269 847.0
TLS2_k127_676588_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 404.0
TLS2_k127_676588_2 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006092 321.0
TLS2_k127_6769805_0 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 586.0
TLS2_k127_6769805_1 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 528.0
TLS2_k127_6769805_2 Belongs to the glycosyl hydrolase 2 family K01195 - 3.2.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 358.0
TLS2_k127_6772959_0 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008861 524.0
TLS2_k127_6789357_0 ABC transporter K06147,K18890 - - 7.239e-207 659.0
TLS2_k127_6789357_1 ABC transporter, transmembrane K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 584.0
TLS2_k127_6789357_2 Sugar transferase - - - 0.0000000000000000000000001653 106.0
TLS2_k127_6789357_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564 - 0.000000000000000006493 83.0
TLS2_k127_6789669_0 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000003618 222.0
TLS2_k127_6817969_0 Na+/H+ antiporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 464.0
TLS2_k127_6817969_1 surface antigen variable number - - - 0.000000000000000000000000000000000009056 151.0
TLS2_k127_6817969_2 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000001007 110.0
TLS2_k127_6817969_3 SurA N-terminal domain K03771 - 5.2.1.8 0.00000004747 65.0
TLS2_k127_6825476_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 428.0
TLS2_k127_6825476_1 Belongs to the MlaE permease family K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000365 287.0
TLS2_k127_6825476_2 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000006024 242.0
TLS2_k127_6825476_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000001652 210.0
TLS2_k127_6825476_4 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000007759 196.0
TLS2_k127_6825476_5 MlaD protein K02067 - - 0.00000004525 64.0
TLS2_k127_6828696_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1023.0
TLS2_k127_6828696_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 330.0
TLS2_k127_6828696_2 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000003698 267.0
TLS2_k127_6828696_3 cheY-homologous receiver domain - - - 0.0000000000000000001316 98.0
TLS2_k127_6834360_0 56kDa selenium binding protein (SBP56) K17285 - - 0.000000000000000000000000000000000000000000001749 171.0
TLS2_k127_6834716_0 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 416.0
TLS2_k127_6834716_1 Domain of unknown function (DUF4188) - - - 0.0003982 46.0
TLS2_k127_6845303_0 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 376.0
TLS2_k127_6845303_1 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006498 296.0
TLS2_k127_6845303_2 RESPONSE REGULATOR receiver - - - 0.000000000000000000000000000000000000000000000000000000000001517 220.0
TLS2_k127_6896048_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 570.0
TLS2_k127_6896048_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.0000000000000000000000000000000000000000000000007829 181.0
TLS2_k127_6907287_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 448.0
TLS2_k127_6907287_1 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008995 336.0
TLS2_k127_6907287_2 - - - - 0.000000000000002824 77.0
TLS2_k127_6907287_3 lipolytic protein G-D-S-L family K20306 - - 0.00000002763 65.0
TLS2_k127_6910047_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002655 296.0
TLS2_k127_6932799_0 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 478.0
TLS2_k127_6932799_1 Pfam:DUF303 K05970 - 3.1.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 477.0
TLS2_k127_6932799_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006712 439.0
TLS2_k127_6932799_3 symporter activity K03307,K11928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 420.0
TLS2_k127_6932799_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 368.0
TLS2_k127_6932799_5 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 295.0
TLS2_k127_6932799_6 Aldo Keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001229 264.0
TLS2_k127_6941560_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 524.0
TLS2_k127_6941560_1 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000002995 161.0
TLS2_k127_6941560_2 PFAM Tetratricopeptide repeat - - - 0.0000000000004029 82.0
TLS2_k127_6941560_3 Carboxypeptidase regulatory-like domain - - - 0.00001744 53.0
TLS2_k127_6941560_4 COG0457 FOG TPR repeat - - - 0.00003114 56.0
TLS2_k127_6941560_5 - K07283 - - 0.0004217 42.0
TLS2_k127_6956608_0 beta-galactosidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007094 258.0
TLS2_k127_6956608_1 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282 - 1.12.99.6 0.000000000000002303 85.0
TLS2_k127_6956608_2 Alpha-L-arabinofuranosidase C-terminus K01209 - 3.2.1.55 0.000000001509 59.0
TLS2_k127_6962635_0 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000006598 89.0
TLS2_k127_6976788_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005711 462.0
TLS2_k127_6976788_1 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007376 358.0
TLS2_k127_6976788_2 multi-organism process K03195 - - 0.00000000000000000000000000002885 125.0
TLS2_k127_6976788_3 Periplasmic or secreted lipoprotein - - - 0.0000000000000001254 89.0
TLS2_k127_6983800_0 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 423.0
TLS2_k127_6983800_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 356.0
TLS2_k127_6983800_2 RecX family - - - 0.000000000002407 74.0
TLS2_k127_6992268_0 Fumarylacetoacetase N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 570.0
TLS2_k127_6992268_1 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 561.0
TLS2_k127_6992268_10 - - - - 0.000000000000008851 89.0
TLS2_k127_6992268_2 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 527.0
TLS2_k127_6992268_3 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 484.0
TLS2_k127_6992268_4 4-Hydroxyphenylpyruvate dioxygenase K00457,K16421 GO:0003674,GO:0003824,GO:0003868,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.27,1.13.11.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 449.0
TLS2_k127_6992268_5 histidyl-tRNA synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000007108 232.0
TLS2_k127_6992268_6 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K01489 - 3.5.4.5 0.000000000000000000000000000000000000000000000000000000461 205.0
TLS2_k127_6992268_7 Diguanylate cyclase K21084 - 2.7.7.65 0.0000000000000000000000000000000000000001418 174.0
TLS2_k127_6992268_8 transcription factor binding K07315,K17763 - 3.1.3.3 0.000000000000000000000000001367 124.0
TLS2_k127_6992268_9 - - - - 0.000000000000000000535 97.0
TLS2_k127_6993915_0 GHMP kinase K05305 - 2.7.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 552.0
TLS2_k127_6993915_1 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000102 125.0
TLS2_k127_6994455_0 copper resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005334 421.0
TLS2_k127_6994455_1 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000149 255.0
TLS2_k127_6994455_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000003406 241.0
TLS2_k127_6994455_3 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000000000000000000000000000000000000000863 198.0
TLS2_k127_6994455_4 PHP domain K04486 - 3.1.3.15 0.000000000000000000000000000000000000001395 158.0
TLS2_k127_6994455_5 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01219 - 3.2.1.81 0.000000000000000000000000000002293 132.0
TLS2_k127_6994455_6 Stress responsive A/B Barrel Domain - - - 0.0003561 48.0
TLS2_k127_6998620_0 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 400.0
TLS2_k127_6998620_1 divalent heavy-metal cations transporter K07238 - - 0.00000000000000000000000000000000000000000000000000000000000000684 228.0
TLS2_k127_6998620_2 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins K03790 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 0.000000000000000000000008645 104.0
TLS2_k127_6999221_0 PA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 592.0
TLS2_k127_6999221_1 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 370.0
TLS2_k127_6999221_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000001479 200.0
TLS2_k127_700471_0 Glycosyl hydrolases family 2, sugar binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 432.0
TLS2_k127_700471_1 Transcriptional regulator - - - 0.00000004725 64.0
TLS2_k127_7005206_0 PFAM tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 9.063e-194 614.0
TLS2_k127_7005206_1 PFAM Xylose isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 349.0
TLS2_k127_7013142_0 alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 480.0
TLS2_k127_7013142_1 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000135 265.0
TLS2_k127_7013142_2 AAA ATPase K07478 - - 0.00000000000000000000000000000000000000000000000000000000000001695 218.0
TLS2_k127_701452_0 Uncharacterised protein family (UPF0182) K09118 - - 0.0 1099.0
TLS2_k127_701452_1 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000947 172.0
TLS2_k127_701452_2 peptidase S9 prolyl oligopeptidase active site - GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000008534 150.0
TLS2_k127_701452_3 Histidine kinase - - - 0.00000000000000000000000000000000000003892 164.0
TLS2_k127_701452_4 peptidase activity K01992 - - 0.000000007853 67.0
TLS2_k127_7015876_0 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006915 351.0
TLS2_k127_7015876_1 Efflux transporter, RND family, MFP subunit K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 307.0
TLS2_k127_7015876_2 Amidohydrolase - - - 0.00000000000000001122 93.0
TLS2_k127_7015876_3 - - - - 0.00000000000222 70.0
TLS2_k127_7015876_4 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000006868 51.0
TLS2_k127_7023612_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 352.0
TLS2_k127_7023612_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000003138 146.0
TLS2_k127_7033582_0 Heparinase II/III N-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 396.0
TLS2_k127_7033582_1 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000004311 205.0
TLS2_k127_7033582_2 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000003572 117.0
TLS2_k127_705429_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 524.0
TLS2_k127_705429_1 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001388 270.0
TLS2_k127_705429_2 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000004992 164.0
TLS2_k127_7054670_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 490.0
TLS2_k127_7054670_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 355.0
TLS2_k127_7054670_2 aldo keto reductase - - - 0.00000000000000000000000000000000005283 146.0
TLS2_k127_7054670_3 Periplasmic Protein K02389 - - 0.0000000000000000001298 98.0
TLS2_k127_7070497_0 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 470.0
TLS2_k127_7070497_1 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 471.0
TLS2_k127_7070497_2 STELLO glycosyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 387.0
TLS2_k127_7070497_3 PFAM Stage II sporulation protein E (SpoIIE) - - - 0.00000000000000000000000000000000000000000000000000000000002811 224.0
TLS2_k127_7070497_4 Glycosyl transferase, family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000002756 164.0
TLS2_k127_7070497_5 PFAM peptidase M28 - - - 0.0000000000000000000000000000000006397 132.0
TLS2_k127_7088440_0 PFAM RNA-directed DNA polymerase (Reverse transcriptase) K00986 - 2.7.7.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000008839 260.0
TLS2_k127_7088440_1 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.00000000000000000000000000000003981 130.0
TLS2_k127_7088440_2 Resolvase - - - 0.000000000000000001857 86.0
TLS2_k127_7088440_3 COG3344 Retron-type reverse transcriptase - - - 0.000000000004851 66.0
TLS2_k127_7088440_4 - - - - 0.00000000953 60.0
TLS2_k127_709613_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 3.549e-229 715.0
TLS2_k127_709613_1 Aromatic amino acid lyase K01745 - 4.3.1.3 7.328e-225 707.0
TLS2_k127_709613_10 Beta-eliminating lyase K01667 - 4.1.99.1 0.00000000000000000000000000000000000000000000001585 173.0
TLS2_k127_709613_11 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 - 2.1.1.200 0.00000000000000000000000000000000000000000000002592 179.0
TLS2_k127_709613_12 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.00000000000000000000000000000000000000000000008354 170.0
TLS2_k127_709613_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 8.461e-201 634.0
TLS2_k127_709613_3 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 504.0
TLS2_k127_709613_4 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 478.0
TLS2_k127_709613_5 Conserved protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 332.0
TLS2_k127_709613_6 Belongs to the arginase family K01479,K12255 - 3.5.3.7,3.5.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 312.0
TLS2_k127_709613_7 radical SAM domain protein K06137,K06138 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001066 278.0
TLS2_k127_709613_8 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000009645 237.0
TLS2_k127_709613_9 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000003322 234.0
TLS2_k127_7100375_0 Peptidase, M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 309.0
TLS2_k127_7100375_1 Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001921 262.0
TLS2_k127_7100375_2 Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000001551 214.0
TLS2_k127_7100375_3 peptidyl-tyrosine sulfation - - - 0.000000000000006585 78.0
TLS2_k127_7106222_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 469.0
TLS2_k127_7106222_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000003812 201.0
TLS2_k127_7106222_2 Putative adhesin - - - 0.00000000000000000000000000000000000000000002869 171.0
TLS2_k127_7111952_0 HI0933-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008433 457.0
TLS2_k127_7111952_1 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 361.0
TLS2_k127_7111952_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K00187 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006677 319.0
TLS2_k127_7113713_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 308.0
TLS2_k127_7113713_1 metallophosphoesterase K07096,K07496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002595 278.0
TLS2_k127_7113713_2 Pyridoxamine 5'-phosphate oxidase like - - - 0.00000000000000000000000000000000000000000000000000000000003456 209.0
TLS2_k127_7113740_0 Male sterility protein K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 356.0
TLS2_k127_7122384_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 342.0
TLS2_k127_7124731_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006116 403.0
TLS2_k127_7124731_1 Hydrolase CocE NonD family K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007561 287.0
TLS2_k127_7124731_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K20866 - 3.1.3.10 0.00000000000000000000000000000000000000000000002724 181.0
TLS2_k127_7124731_3 His Kinase A (phosphoacceptor) domain K14982 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.000000000000003714 80.0
TLS2_k127_7124731_4 alpha-L-rhamnosidase - - - 0.0000004986 53.0
TLS2_k127_7124731_5 response regulator, receiver K07667 - - 0.00002366 51.0
TLS2_k127_7130107_0 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 483.0
TLS2_k127_7130107_1 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 443.0
TLS2_k127_7130107_2 Uroporphyrinogen decarboxylase (URO-D) K01599,K14080 - 2.1.1.246,4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 304.0
TLS2_k127_7130107_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000001791 228.0
TLS2_k127_7130107_4 ZIP Zinc transporter K07238,K16267 - - 0.000000000000000000000000000000000000000000000000000000009043 207.0
TLS2_k127_7130107_5 TIGRFAM Diguanylate cyclase - - - 0.000000000000000000000000000000000569 148.0
TLS2_k127_7130107_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000001304 59.0
TLS2_k127_7130107_7 repeat protein - - - 0.00003943 55.0
TLS2_k127_7130107_8 TM2 domain - - - 0.0001576 49.0
TLS2_k127_7130182_0 PA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 477.0
TLS2_k127_7130182_1 abc transporter atp-binding protein K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 406.0
TLS2_k127_7130182_2 FAD binding domain K00103,K00279 - 1.1.3.8,1.5.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 298.0
TLS2_k127_7130182_3 PRC-barrel domain - - - 0.00000000000000000000000000000000002472 138.0
TLS2_k127_7130182_4 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000001862 144.0
TLS2_k127_7130410_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 2.261e-199 632.0
TLS2_k127_7130410_1 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.000000000000000000000000000000000000000004092 158.0
TLS2_k127_7130410_2 protein methyltransferase activity - - - 0.0000000000000000000000000000000001096 136.0
TLS2_k127_7135393_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 4.883e-313 970.0
TLS2_k127_7135393_1 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004501 539.0
TLS2_k127_7135393_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 526.0
TLS2_k127_7135393_3 Domain of unknown function (DUF2088) K22373 - 5.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008082 444.0
TLS2_k127_7135393_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000506 250.0
TLS2_k127_7135393_5 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000000000000003816 223.0
TLS2_k127_7135393_6 dCMP deaminase activity K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000001676 201.0
TLS2_k127_7135393_7 Methyltransferase type 11 K00570 - 2.1.1.17,2.1.1.71 0.0000000000000000000000000000000000000000000000002303 183.0
TLS2_k127_7135393_8 AAA domain - - - 0.00000000000000000000000000002948 129.0
TLS2_k127_7135393_9 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000006148 103.0
TLS2_k127_7137565_0 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005377 276.0
TLS2_k127_7137565_1 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000135 251.0
TLS2_k127_7137565_2 - - - - 0.00000000000000000000000000000000000000000008522 173.0
TLS2_k127_7137565_3 Domain of Unknown Function (DUF1080) - - - 0.0000000000003743 73.0
TLS2_k127_714491_0 Cytochrome bd-type quinol oxidase subunit 1 K00425 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 518.0
TLS2_k127_714491_1 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 356.0
TLS2_k127_714491_2 oxidase, subunit K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 339.0
TLS2_k127_714491_3 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000001145 111.0
TLS2_k127_7145689_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1295.0
TLS2_k127_7145689_1 Belongs to the peptidase M48B family K03799 - - 0.00000002794 56.0
TLS2_k127_7146353_0 Integrase core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 501.0
TLS2_k127_7146353_1 Bacterial dnaA protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002811 254.0
TLS2_k127_7148084_0 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007673 301.0
TLS2_k127_7148084_1 COG1349 Transcriptional regulators of sugar metabolism - - - 0.000000000000000000000000000000000000000000003975 170.0
TLS2_k127_7148084_2 PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis protein - - - 0.00000000000000000000000000000000006364 137.0
TLS2_k127_7148084_3 Belongs to the UPF0251 family - - - 0.000000000000000000000000000000388 125.0
TLS2_k127_71574_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 493.0
TLS2_k127_71574_1 TIGRFAM glutamate synthases, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 318.0
TLS2_k127_71574_2 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001175 267.0
TLS2_k127_71574_3 Yqey-like protein K09117 - - 0.000000000000000000000000000005003 124.0
TLS2_k127_7158227_0 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003417 317.0
TLS2_k127_7158227_1 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000003062 198.0
TLS2_k127_7158227_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K07516 - 1.1.1.35 0.00000000000000000000000001513 111.0
TLS2_k127_7174543_0 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 294.0
TLS2_k127_7174543_1 Trypsin-like serine protease - - - 0.000000000000000000000000000000000000000000000000000000000006128 217.0
TLS2_k127_7174543_2 Belongs to the serpin family K13963 - - 0.000000000000000265 83.0
TLS2_k127_7174698_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 1.052e-229 724.0
TLS2_k127_7174698_1 cell adhesion involved in biofilm formation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 333.0
TLS2_k127_7174698_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000002482 168.0
TLS2_k127_7177619_0 Domain of unknown function (DUF1846) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 452.0
TLS2_k127_7177619_1 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 292.0
TLS2_k127_7186383_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 6.088e-280 882.0
TLS2_k127_7186383_1 Domain present in PSD-95, Dlg, and ZO-1/2. K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009539 397.0
TLS2_k127_7186383_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000001983 63.0
TLS2_k127_7190509_0 Protein of unknown function (DUF3500) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001645 284.0
TLS2_k127_7190509_1 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000000347 179.0
TLS2_k127_7190509_2 Glycogen recognition site of AMP-activated protein kinase K01442 - 3.5.1.24 0.00000003026 59.0
TLS2_k127_719203_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 301.0
TLS2_k127_7195554_0 Carboxyl transferase domain - - - 5.452e-216 683.0
TLS2_k127_7195554_1 NUDIX domain - GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818 - 0.00000000000000000000000000001338 125.0
TLS2_k127_7195554_2 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000001642 132.0
TLS2_k127_7195554_3 Biotin-requiring enzyme - - - 0.000000002217 63.0
TLS2_k127_7207203_0 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955 - 2.7.1.25,2.7.7.4 1.66e-201 645.0
TLS2_k127_7207203_1 PFAM Phosphoadenosine phosphosulfate reductase K00390,K00957 - 1.8.4.10,1.8.4.8,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006202 471.0
TLS2_k127_7207203_2 Nitrite and sulphite reductase 4Fe-4S K00366,K00381,K00392 - 1.7.7.1,1.8.1.2,1.8.7.1 0.00000000000000000000000000000000000000000000000000000000001321 214.0
TLS2_k127_7207203_3 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000007983 159.0
TLS2_k127_7229993_0 Catalyzes the conversion of L-arabinose to L-ribulose K01804 - 5.3.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 585.0
TLS2_k127_7229993_1 Major Facilitator Superfamily K08191 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008667 391.0
TLS2_k127_7229993_2 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000005546 229.0
TLS2_k127_7242858_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K08323 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0047929,GO:0071704,GO:1901575 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 545.0
TLS2_k127_7242858_1 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000001833 199.0
TLS2_k127_7242858_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000003434 169.0
TLS2_k127_7254359_0 zinc ion transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 322.0
TLS2_k127_7254359_1 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 301.0
TLS2_k127_7254359_2 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003924 260.0
TLS2_k127_7254359_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000003372 155.0
TLS2_k127_7254866_0 Two component regulator propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001106 273.0
TLS2_k127_7254866_1 membrane protein domain - - - 0.000006514 53.0
TLS2_k127_726184_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 523.0
TLS2_k127_726184_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 338.0
TLS2_k127_726184_2 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000000000004994 188.0
TLS2_k127_726184_3 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000008686 141.0
TLS2_k127_726184_4 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins K03466 - - 0.000000000004682 76.0
TLS2_k127_7285999_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 589.0
TLS2_k127_7285999_1 PFAM Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 539.0
TLS2_k127_7285999_2 DNA photolyase activity K03716 - 4.1.99.14 0.00000000000000000000000000000000000000000000000000000000000000000000001407 252.0
TLS2_k127_7285999_3 PFAM EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000177 190.0
TLS2_k127_7285999_4 Belongs to the ParB family K03497 - - 0.0000002047 62.0
TLS2_k127_7292197_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000009538 223.0
TLS2_k127_7292197_1 YceI-like domain - - - 0.0000000000000000000000000000000000003665 147.0
TLS2_k127_7292197_3 - - - - 0.000000000000000000000000000005534 121.0
TLS2_k127_7292197_4 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) - - - 0.00000000000000000000005045 110.0
TLS2_k127_7292197_5 - - - - 0.000000003118 68.0
TLS2_k127_729260_0 Protein of unknown function (DUF1349) K09702 - - 0.00000000000000000000000000000000000000000003025 172.0
TLS2_k127_729260_1 galactose mutarotase K01785 - 5.1.3.3 0.000000000000000000000001425 114.0
TLS2_k127_729260_2 ATP-dependent helicase K03579 - 3.6.4.13 0.000001301 51.0
TLS2_k127_729260_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00003019 55.0
TLS2_k127_7301767_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 400.0
TLS2_k127_7301767_1 N-terminal domain of Peptidase_S41 in eukaryotic IRBP - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 337.0
TLS2_k127_7301767_2 Transcriptional regulator K07506 - - 0.0000000000000001107 86.0
TLS2_k127_7315093_0 Pfam:DUF1446 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008398 509.0
TLS2_k127_7315093_1 Enoyl-CoA hydratase/isomerase K13766 - 4.2.1.18 0.000000000000000000000000000000000000000000000000000000000179 212.0
TLS2_k127_7315093_2 ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000003518 147.0
TLS2_k127_7315093_3 - - - - 0.000000000000000000000000002864 115.0
TLS2_k127_7319122_0 PhoPQ-activated pathogenicity-related protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 499.0
TLS2_k127_7319122_1 PFAM peptidase M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 384.0
TLS2_k127_7319122_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000006689 180.0
TLS2_k127_7319122_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000005246 128.0
TLS2_k127_7319122_4 MacB-like periplasmic core domain K02004 - - 0.00000001887 58.0
TLS2_k127_7320925_0 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 475.0
TLS2_k127_7320925_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 304.0
TLS2_k127_7320925_2 Trehalose utilisation K09992 - - 0.0000000000000000000000000000000000000000000000000000000000000002592 226.0
TLS2_k127_7320925_3 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000000000000000000004221 132.0
TLS2_k127_7320925_4 Carboxypeptidase regulatory-like domain - - - 0.0000000001346 69.0
TLS2_k127_7322287_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 334.0
TLS2_k127_7322287_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002784 280.0
TLS2_k127_7322287_2 TonB-dependent Receptor Plug Domain K02014,K16092 - - 0.00000000000000000000000000000000000000000000000007621 197.0
TLS2_k127_7322287_3 Domain of unknown function (DUF2520) - - - 0.00000000000000000000000000000000000000000000002998 181.0
TLS2_k127_7322287_4 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000000000000322 166.0
TLS2_k127_7322287_5 Glycine cleavage H-protein - - - 0.0000000000000008676 81.0
TLS2_k127_7322406_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 6.996e-321 993.0
TLS2_k127_7322406_1 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 1.196e-286 900.0
TLS2_k127_7322406_2 alpha amylase, catalytic K01236 - 3.2.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 544.0
TLS2_k127_7324487_0 hydrolase, family 65, central catalytic K15923 - 3.2.1.51 3.696e-274 864.0
TLS2_k127_7324487_1 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008411 581.0
TLS2_k127_7324487_2 COG0530 Ca2 Na antiporter K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 401.0
TLS2_k127_7324487_3 dehydrogenases and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 386.0
TLS2_k127_7324487_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 368.0
TLS2_k127_7324487_5 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000007659 233.0
TLS2_k127_7324487_6 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000004265 184.0
TLS2_k127_7324487_7 protein with SCP PR1 domains - - - 0.0000000000000000000000000000000000001003 149.0
TLS2_k127_7324487_8 Sigma factor PP2C-like phosphatases - - - 0.00000000000001883 80.0
TLS2_k127_7325993_0 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 488.0
TLS2_k127_7325993_1 Transposase domain (DUF772) - - - 0.00000000000000000000000000277 123.0
TLS2_k127_7325993_2 Histidine kinase-like ATPases K07673 - 2.7.13.3 0.00006735 46.0
TLS2_k127_7326827_0 PFAM von Willebrand factor type A - - - 0.0000000000000000000000000000000000000000000000000000001135 211.0
TLS2_k127_7326827_1 COG0500 SAM-dependent methyltransferases - - - 0.00000009001 62.0
TLS2_k127_7344339_0 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004641 252.0
TLS2_k127_7344339_1 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000377 233.0
TLS2_k127_7344339_2 accessory protein K06959 - - 0.00000000000000000000000000000000000000000000000000000001652 200.0
TLS2_k127_7344339_3 Putative zinc- or iron-chelating domain - - - 0.0000000000000000000000000000000000000000000000604 177.0
TLS2_k127_7344339_4 LD-carboxypeptidase K01297 - 3.4.17.13 0.000000000000000000000000000000000000002283 148.0
TLS2_k127_7349672_0 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 2.3e-310 977.0
TLS2_k127_7349672_1 belongs to the thioredoxin family K03671,K05838 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 8.827e-196 629.0
TLS2_k127_7349672_2 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 594.0
TLS2_k127_7349672_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 554.0
TLS2_k127_7349672_4 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008634 281.0
TLS2_k127_7349672_5 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001241 275.0
TLS2_k127_7349672_6 oxidation-reduction process K18239,K18240 GO:0003674,GO:0003824,GO:0016787,GO:0016801,GO:0016803 3.3.2.13,4.1.3.40,4.1.3.45 0.0000000000000000000000000000000000000000000000000000004136 199.0
TLS2_k127_7349672_7 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000003417 158.0
TLS2_k127_7349672_8 Tetratricopeptide repeat - - - 0.0000000001778 73.0
TLS2_k127_7361474_0 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000002541 223.0
TLS2_k127_7361474_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000005137 134.0
TLS2_k127_7361474_2 glycosyl transferase group 1 - - - 0.00000000000000000002014 101.0
TLS2_k127_7365329_0 DNA polymerase X family K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 568.0
TLS2_k127_7365329_1 nuclear chromosome segregation - - - 0.0000000000000462 85.0
TLS2_k127_7365329_2 Transposase DDE domain - - - 0.0000001466 53.0
TLS2_k127_7368812_0 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000782 256.0
TLS2_k127_7368812_1 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000000000000000000000000000000000001605 199.0
TLS2_k127_7368812_2 Phage integrase family - - - 0.00000000000000000000001864 109.0
TLS2_k127_7368812_3 Protein of unknown function (DUF433) - - - 0.0000000000000000003271 89.0
TLS2_k127_7368812_4 Phage integrase, N-terminal SAM-like domain - - - 0.00000000000000233 77.0
TLS2_k127_7368812_5 - - - - 0.00000000002068 67.0
TLS2_k127_737297_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 386.0
TLS2_k127_737297_1 beta-N-acetylhexosaminidase activity - - - 0.00000000000000000003988 92.0
TLS2_k127_7405382_0 Aldo/keto reductase family K07079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 359.0
TLS2_k127_7405382_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00003146 52.0
TLS2_k127_7430867_0 G-rich domain on putative tyrosine kinase K08252,K16554 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 430.0
TLS2_k127_7430867_1 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 399.0
TLS2_k127_7439082_0 Amino acid adenylation domain - - - 0.0 1314.0
TLS2_k127_7439082_1 Amino acid adenylation domain protein - - - 1.494e-263 844.0
TLS2_k127_7439082_2 Belongs to the ATP-dependent AMP-binding enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007163 575.0
TLS2_k127_7439082_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 534.0
TLS2_k127_7439082_4 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009419 452.0
TLS2_k127_7439082_5 ornithine cyclodeaminase activity K01750,K20500 - 4.3.1.12,4.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 407.0
TLS2_k127_7439082_6 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.0000000000000000000000000000000000000000000000000000000007068 210.0
TLS2_k127_7448485_0 membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 323.0
TLS2_k127_7448485_1 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000001162 219.0
TLS2_k127_7448485_2 Protein of unknown function (DUF421) - - - 0.0000000000000000000000000000000000000000000001036 173.0
TLS2_k127_7448485_3 - - - - 0.00000000000003301 73.0
TLS2_k127_7448485_4 - - - - 0.000000001012 70.0
TLS2_k127_7454582_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 1.545e-204 650.0
TLS2_k127_7454582_1 Thioesterase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007001 379.0
TLS2_k127_7454582_2 MbtH-like protein K05375 - - 0.0000000000000000000000000000000001056 133.0
TLS2_k127_7469825_0 AAA domain (Cdc48 subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 462.0
TLS2_k127_7469825_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000128 264.0
TLS2_k127_7469825_2 - - - - 0.0004736 50.0
TLS2_k127_748398_0 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000424 263.0
TLS2_k127_748398_1 Peptidase M1, membrane alanine aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000002421 220.0
TLS2_k127_748398_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000004623 108.0
TLS2_k127_772853_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 364.0
TLS2_k127_772853_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 355.0
TLS2_k127_772853_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000002375 244.0
TLS2_k127_772853_3 Redoxin K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000006466 235.0
TLS2_k127_772853_4 PFAM ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000002917 230.0
TLS2_k127_772853_5 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000006435 175.0
TLS2_k127_772853_6 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.0000000000000007176 93.0
TLS2_k127_772853_7 TonB-dependent Receptor Plug Domain K02014,K16092 - - 0.00000000889 58.0
TLS2_k127_772853_8 - - - - 0.00002126 57.0
TLS2_k127_775075_0 protein kinase activity - - - 0.000000000000000000000000000000000000000000000002223 196.0
TLS2_k127_775075_1 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000003868 143.0
TLS2_k127_787717_0 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 379.0
TLS2_k127_787717_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 348.0
TLS2_k127_787717_2 Carbamoyltransferase C-terminus K00612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 334.0
TLS2_k127_792927_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 538.0
TLS2_k127_792927_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002349 277.0
TLS2_k127_799939_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 502.0
TLS2_k127_799939_1 COGs COG2303 Choline dehydrogenase and related flavoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002494 288.0
TLS2_k127_799939_2 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000001423 262.0
TLS2_k127_799939_3 Belongs to the UPF0109 family K06960 - - 0.0000000000000000000000000009166 115.0
TLS2_k127_799939_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000008489 109.0
TLS2_k127_799939_5 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000002996 99.0
TLS2_k127_800093_0 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006596 551.0
TLS2_k127_800093_1 aldo keto reductase K19265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 479.0
TLS2_k127_816795_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00336 - 1.6.5.3 7.667e-238 753.0
TLS2_k127_816795_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 469.0
TLS2_k127_816795_2 PFAM oxidoreductase FAD NAD(P)-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 374.0
TLS2_k127_816795_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 315.0
TLS2_k127_816795_4 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.000000000000000000000000000000000000004928 154.0
TLS2_k127_816795_5 spore germination K00442,K08315 - 3.4.23.51 0.0000000000000000000000000000000000003435 145.0
TLS2_k127_816795_6 Pfam:N_methyl_2 - - - 0.000000000007848 70.0
TLS2_k127_817104_0 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 366.0
TLS2_k127_817104_1 PFAM Class II aldolase K03077 - 5.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005463 310.0
TLS2_k127_817104_2 Curli production assembly/transport component CsgG - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 299.0
TLS2_k127_817104_3 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 291.0
TLS2_k127_817104_4 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002315 246.0
TLS2_k127_817104_5 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) - - - 0.00000000000000000000000000000000000000000299 166.0
TLS2_k127_817104_6 membrane-bound metal-dependent hydrolase K07038 - - 0.0000000000000000000000000000001692 137.0
TLS2_k127_817104_8 23S rRNA-intervening sequence protein - - - 0.0000000000002048 71.0
TLS2_k127_817104_9 - - - - 0.000002284 57.0
TLS2_k127_832686_0 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001105 272.0
TLS2_k127_832686_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000001635 237.0
TLS2_k127_832686_2 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000001135 148.0
TLS2_k127_83909_0 Linear amide C-N hydrolases, choloylglycine hydrolase family K01442 - 3.5.1.24 0.000000000000000000000000000000000000000000000000000000000002343 226.0
TLS2_k127_846503_0 Hydrophobe amphiphile efflux-1 HAE1 K03296 - - 0.0 1069.0
TLS2_k127_846503_1 Beta-galactosidase trimerisation domain K12308 - 3.2.1.23 1.562e-254 803.0
TLS2_k127_846503_2 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 478.0
TLS2_k127_846503_3 CAAX prenyl protease N-terminal, five membrane helices - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 466.0
TLS2_k127_846503_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000126 284.0
TLS2_k127_863344_0 TIGRFAM amino acid adenylation domain - - - 1.294e-257 848.0
TLS2_k127_863344_1 protein-(glutamine-N5) methyltransferase activity K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005067 290.0
TLS2_k127_863344_2 COGs COG3319 Thioesterase domains of type I polyketide synthase or non-ribosomal peptide synthetase - - - 0.00000000000000000000000000000000000000000000000000001069 218.0
TLS2_k127_863344_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000012 155.0
TLS2_k127_865649_0 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 549.0
TLS2_k127_865649_1 Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006028 514.0
TLS2_k127_868374_0 PFAM sulfatase - - - 2.031e-196 624.0
TLS2_k127_868374_1 Major facilitator Superfamily K03292,K16248 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 500.0
TLS2_k127_868374_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 499.0
TLS2_k127_872584_0 CHAT domain - - - 0.000000000000000000000000008831 128.0
TLS2_k127_872584_1 ATPase (AAA superfamily) K06921 - - 0.00000000000000000000006039 104.0
TLS2_k127_872584_2 Peptidase_C39 like family - - - 0.00008203 51.0
TLS2_k127_885159_0 With PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 330.0
TLS2_k127_885159_1 TIGRFAM Phenylacetate-CoA oxygenase, PaaI subunit K02611 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002901 284.0
TLS2_k127_885159_2 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000002512 207.0
TLS2_k127_885159_3 TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit K02612 - - 0.00000000000000000000000000000000000000000001814 168.0
TLS2_k127_885159_4 phenylacetic acid degradation K02610 - - 0.000000000000000000000000000000000211 139.0
TLS2_k127_886217_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K02549,K19802 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 4.2.1.113,5.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 485.0
TLS2_k127_886217_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 440.0
TLS2_k127_886217_2 NlpC/P60 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000203 256.0
TLS2_k127_886217_3 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000001532 208.0
TLS2_k127_886217_4 Domain of unknown function (DUF1835) - - - 0.000000000000000000000000000000000000000000000000004924 190.0
TLS2_k127_886217_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000001232 50.0
TLS2_k127_896110_0 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 3.904e-195 617.0
TLS2_k127_896110_1 PFAM glycosyl transferase family 9 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 321.0
TLS2_k127_901437_0 Beta-lactamase - - - 3.423e-214 684.0
TLS2_k127_901437_1 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 587.0
TLS2_k127_901437_2 Glycosyl transferases group 1 - - - 0.000000002028 63.0
TLS2_k127_90346_0 ABC1 family K03688 - - 4.757e-265 824.0
TLS2_k127_90346_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009563 605.0
TLS2_k127_90346_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 413.0
TLS2_k127_90346_3 nucleotidyltransferase activity - - - 0.00000000000000000000000000000005275 127.0
TLS2_k127_90346_4 Transposase - - - 0.00000003469 55.0
TLS2_k127_906211_0 cation transport ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002868 259.0
TLS2_k127_922105_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 376.0
TLS2_k127_922105_1 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007132 374.0
TLS2_k127_922105_2 Transglycosylase SLT domain K01185 - 3.2.1.17 0.0000000000000000000000000000000000000002408 158.0
TLS2_k127_981546_0 phosphoglycerate kinase activity K00927,K01803 GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 412.0
TLS2_k127_981546_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 297.0
TLS2_k127_981546_2 Preprotein translocase SecG subunit K03075 - - 0.00000000000000002158 87.0
TLS2_k127_994214_0 thiolester hydrolase activity K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 500.0
TLS2_k127_994214_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009668 479.0
TLS2_k127_994214_2 esterase K07214 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 408.0
TLS2_k127_994557_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006669 452.0
TLS2_k127_994557_1 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 344.0
TLS2_k127_994557_2 Right handed beta helix region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 318.0
TLS2_k127_994557_3 Activator of Hsp90 ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000001241 219.0
TLS2_k127_994557_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000002846 158.0
TLS2_k127_999280_0 Alpha amylase, catalytic domain K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004595 515.0