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Overview

ID MAG04007
Name TLS2_bin.46
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Rhizobiales
Family Hyphomicrobiaceae
Genus Ga0077530
Species
Assembly information
Completeness (%) 87.4
Contamination (%) 1.36
GC content (%) 66.0
N50 (bp) 16,177
Genome size (bp) 3,659,135

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3344

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1017924_0 Carbamoyl-phosphate synthase L chain K01968 - 6.4.1.4 1.016e-209 675.0
TLS2_k127_1017924_1 NYN domain - - - 1.861e-197 633.0
TLS2_k127_1017924_10 Stringent starvation protein B K09985 - - 0.0000000000000000000000000000000000000000000000000001551 196.0
TLS2_k127_1017924_11 Tetratricopeptide repeat-like domain - - - 0.000000000000000000000000000000000000000000000004167 183.0
TLS2_k127_1017924_12 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000001614 173.0
TLS2_k127_1017924_13 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000001155 134.0
TLS2_k127_1017924_2 PQQ-like domain K17713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008372 466.0
TLS2_k127_1017924_3 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 418.0
TLS2_k127_1017924_4 cobalamin synthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 353.0
TLS2_k127_1017924_5 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 320.0
TLS2_k127_1017924_6 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000004661 268.0
TLS2_k127_1017924_7 Acetyltransferase (GNAT) domain K00663 - 2.3.1.82 0.00000000000000000000000000000000000000000000000000000000000000000005913 235.0
TLS2_k127_1017924_8 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000008351 244.0
TLS2_k127_1017924_9 Protein of unknown function (DUF1489) - - - 0.00000000000000000000000000000000000000000000000000001877 194.0
TLS2_k127_1060089_0 Aconitase family (aconitate hydratase) - - - 4.456e-230 720.0
TLS2_k127_1060089_1 COG1053 Succinate dehydrogenase fumarate reductase flavoprotein subunit K13796 - - 3.981e-222 698.0
TLS2_k127_1060089_10 intermembrane phospholipid transfer K07323 - - 0.000000000000000000000000000000000000000188 157.0
TLS2_k127_1060089_12 COG0563 Adenylate kinase and related - - - 0.0000001244 54.0
TLS2_k127_1060089_2 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 492.0
TLS2_k127_1060089_3 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 409.0
TLS2_k127_1060089_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 344.0
TLS2_k127_1060089_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007135 306.0
TLS2_k127_1060089_6 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 309.0
TLS2_k127_1060089_7 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001012 244.0
TLS2_k127_1060089_8 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000218 253.0
TLS2_k127_1060089_9 DSBA-like thioredoxin domain K07396 - - 0.000000000000000000000000000000000000000000000000000000000000000002371 234.0
TLS2_k127_1126206_0 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002351 364.0
TLS2_k127_1126206_1 Glycosyltransferase like family 2 K20534 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 366.0
TLS2_k127_1126206_2 GTP cyclohydrolase II K01497,K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 289.0
TLS2_k127_1126206_3 polysaccharide biosynthetic process - - - 0.0000000000000009501 83.0
TLS2_k127_114118_0 Diguanylate cyclase phosphodiesterase with PAS PAC K13245 - 3.1.4.52 0.0 1162.0
TLS2_k127_114118_1 ABC transporter K06147 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576 - 1.957e-291 908.0
TLS2_k127_114118_10 MraZ protein, putative antitoxin-like K03925 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003521 247.0
TLS2_k127_114118_11 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000000000000002276 237.0
TLS2_k127_114118_12 Chain length determinant protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000751 256.0
TLS2_k127_114118_13 - - - - 0.000000000000008112 78.0
TLS2_k127_114118_2 AMP-binding enzyme C-terminal domain K00666,K02182,K20034 - 6.2.1.44,6.2.1.48 2.374e-265 827.0
TLS2_k127_114118_3 Threonine synthase K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 528.0
TLS2_k127_114118_4 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 472.0
TLS2_k127_114118_5 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009705 381.0
TLS2_k127_114118_6 ErfK YbiS YcfS YnhG family protein K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 380.0
TLS2_k127_114118_7 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003313 352.0
TLS2_k127_114118_8 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 324.0
TLS2_k127_114118_9 penicillin-binding protein K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 325.0
TLS2_k127_1169296_0 Thiamine pyrophosphate enzyme, central domain K03852 - 2.3.3.15 0.0 1047.0
TLS2_k127_1169296_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 2.249e-253 796.0
TLS2_k127_1169296_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000001607 216.0
TLS2_k127_1169296_4 YceI-like domain - - - 0.0000000000000000000000000000000000001656 149.0
TLS2_k127_1171152_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 0.0 1188.0
TLS2_k127_1171152_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007508 562.0
TLS2_k127_1171152_10 Belongs to the 'phage' integrase family - - - 0.0000000000000000000005496 103.0
TLS2_k127_1171152_11 EF-hand, calcium binding motif - - - 0.000000002544 68.0
TLS2_k127_1171152_12 - - - - 0.000001897 57.0
TLS2_k127_1171152_13 Small protein - - - 0.00006198 49.0
TLS2_k127_1171152_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 533.0
TLS2_k127_1171152_3 ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 422.0
TLS2_k127_1171152_4 Lipopolysaccharide-assembly, LptC-related K09774 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008677 404.0
TLS2_k127_1171152_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003591 382.0
TLS2_k127_1171152_6 Transcriptional regulator K02483 GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 366.0
TLS2_k127_1171152_7 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 338.0
TLS2_k127_1171152_8 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 313.0
TLS2_k127_1171152_9 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000001767 231.0
TLS2_k127_1182305_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 5.484e-209 657.0
TLS2_k127_1182305_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004479 547.0
TLS2_k127_1182305_10 Trap-type c4-dicarboxylate transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000006023 188.0
TLS2_k127_1182305_11 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000000000000005427 186.0
TLS2_k127_1182305_12 Cytochrome c K17223 - - 0.000000000000000000000000000000000000000000000000024 185.0
TLS2_k127_1182305_13 Sulfur oxidation protein SoxY K17226 - - 0.000000000000000000000000000000000000000000000005161 176.0
TLS2_k127_1182305_14 Sulphur oxidation protein SoxZ - - - 0.000000000000000000000000000000000000009436 159.0
TLS2_k127_1182305_15 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.0000000000000000001122 93.0
TLS2_k127_1182305_16 cytochrome - - - 0.000000000000000009478 86.0
TLS2_k127_1182305_2 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 503.0
TLS2_k127_1182305_3 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 464.0
TLS2_k127_1182305_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005264 437.0
TLS2_k127_1182305_5 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 398.0
TLS2_k127_1182305_6 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 306.0
TLS2_k127_1182305_7 MgtC family K07507 - - 0.000000000000000000000000000000000000000000000000000000000001163 214.0
TLS2_k127_1182305_8 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000005312 214.0
TLS2_k127_1182305_9 SnoaL-like polyketide cyclase K07255 - - 0.0000000000000000000000000000000000000000000000000000003825 195.0
TLS2_k127_1183903_0 Ribosomal protein S2 K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 466.0
TLS2_k127_1183903_1 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007989 373.0
TLS2_k127_1183903_2 PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A K01895,K01908 - 6.2.1.1,6.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 353.0
TLS2_k127_1183903_3 oxidation-reduction process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 353.0
TLS2_k127_1183903_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0003674,GO:0003824,GO:0004735,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 320.0
TLS2_k127_1183903_5 2-oxopent-4-enoate hydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000001335 242.0
TLS2_k127_1183903_6 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000007583 229.0
TLS2_k127_1183903_7 transcriptional regulator - - - 0.0000000000000000000000000000000000000000003983 168.0
TLS2_k127_1183903_8 PFAM Methyltransferase type - - - 0.000000000000000000000000001638 115.0
TLS2_k127_1185764_0 epimerase dehydratase K12454 - 5.1.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 530.0
TLS2_k127_1185764_1 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 512.0
TLS2_k127_1185764_10 - - - - 0.0000000000000000005078 99.0
TLS2_k127_1185764_11 - - - - 0.00000000000000003295 93.0
TLS2_k127_1185764_12 Arylsulfotransferase (ASST) - - - 0.000000002539 69.0
TLS2_k127_1185764_13 PFAM glycoside hydrolase family 39 K01198 - 3.2.1.37 0.00000001576 67.0
TLS2_k127_1185764_15 prohibitin homologues - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00013 51.0
TLS2_k127_1185764_2 gluconolactonase K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 420.0
TLS2_k127_1185764_3 Macrocin-O-methyltransferase (TylF) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004312 265.0
TLS2_k127_1185764_4 Pfam:Pyridox_oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004952 262.0
TLS2_k127_1185764_5 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000001271 222.0
TLS2_k127_1185764_6 epimerase dehydratase family K01784,K08679 - 5.1.3.2,5.1.3.6 0.0000000000000000000000000000000000000000000000000000000002198 215.0
TLS2_k127_1185764_7 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000000000000000000000000000702 217.0
TLS2_k127_1185764_8 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000008994 129.0
TLS2_k127_1185764_9 - - - - 0.000000000000000000008041 106.0
TLS2_k127_1224066_0 Cytochrome c554 and c-prime - - - 2.922e-308 959.0
TLS2_k127_1224066_1 - - - - 1.247e-236 749.0
TLS2_k127_1224066_10 cytochrome complex assembly K02200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001595 248.0
TLS2_k127_1224066_11 Isoprenylcysteine carboxyl methyltransferase K16168 - - 0.000000000000000000000000000000000000000000000000000007738 203.0
TLS2_k127_1224066_12 TadE-like protein K02651 - - 0.000000000000000000000007915 111.0
TLS2_k127_1224066_13 Flp pilus assembly protein TadG - - - 0.000000000000002352 85.0
TLS2_k127_1224066_14 carboxymuconolactone decarboxylase - - - 0.000000000000003683 88.0
TLS2_k127_1224066_15 5-aminolevulinic acid synthase K00643 - 2.3.1.37 0.00000002746 56.0
TLS2_k127_1224066_16 PFAM Flp Fap pilin component K02651 - - 0.0000008843 53.0
TLS2_k127_1224066_2 - - - - 2.817e-229 732.0
TLS2_k127_1224066_3 Oxidoreductase FAD NAD(P)-binding domain protein K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 532.0
TLS2_k127_1224066_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 420.0
TLS2_k127_1224066_6 Chalcone and stilbene synthases, C-terminal domain K16167 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007734 404.0
TLS2_k127_1224066_7 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 400.0
TLS2_k127_1224066_8 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 394.0
TLS2_k127_1224066_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008031 311.0
TLS2_k127_123914_0 Cytochrome c-type biogenesis protein K02198 - - 0.0 1008.0
TLS2_k127_123914_1 Serine aminopeptidase, S33 K01253,K08253 - 2.7.10.2,3.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 506.0
TLS2_k127_123914_10 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000000002238 172.0
TLS2_k127_123914_11 PFAM regulatory protein ArsR - - - 0.00000000000000000000000000000004563 130.0
TLS2_k127_123914_12 Cytochrome c K08738 - - 0.00000000000000001401 89.0
TLS2_k127_123914_2 Signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005391 484.0
TLS2_k127_123914_3 Two component transcriptional regulator K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 381.0
TLS2_k127_123914_4 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 368.0
TLS2_k127_123914_5 KR domain K00038 - 1.1.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 351.0
TLS2_k127_123914_6 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 338.0
TLS2_k127_123914_7 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 324.0
TLS2_k127_123914_8 Cytochrome c-type biogenesis protein K02200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003561 280.0
TLS2_k127_123914_9 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.0000000000000000000000000000000000000000000005828 183.0
TLS2_k127_1241870_0 Domain of unknown function (DUF4175) - - - 4.118e-248 793.0
TLS2_k127_1241870_1 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 1.027e-237 743.0
TLS2_k127_1241870_2 Binding-protein-dependent transport system inner membrane component K02011 - - 8.89e-201 644.0
TLS2_k127_1241870_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 581.0
TLS2_k127_1241870_4 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 353.0
TLS2_k127_1241870_5 reductase - - - 0.00000000000000000000000000000000000000000000000000000000001122 208.0
TLS2_k127_1241870_6 Thioredoxin-like - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000002812 191.0
TLS2_k127_1249863_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 1007.0
TLS2_k127_1249863_1 MMPL family K07003 - - 2.17e-322 1006.0
TLS2_k127_1249863_2 OpgC protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 387.0
TLS2_k127_1249863_3 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 340.0
TLS2_k127_1249863_4 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002822 282.0
TLS2_k127_1249863_5 Type VI secretion system (T6SS), amidase effector protein 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001141 272.0
TLS2_k127_1249863_6 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000000000000001372 179.0
TLS2_k127_1320297_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 0.0 2262.0
TLS2_k127_1320297_1 PFAM major facilitator superfamily MFS_1 K02575 - - 0.0 1593.0
TLS2_k127_1320297_2 nitrate reductase beta subunit K00371 - 1.7.5.1 0.000000000000000000000000000947 112.0
TLS2_k127_1391806_0 domain, Protein - - - 0.0 1041.0
TLS2_k127_1391806_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit K00166 - 1.2.4.4 2.277e-220 689.0
TLS2_k127_1391806_10 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 387.0
TLS2_k127_1391806_11 PFAM Glutathione S-transferase domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000144 275.0
TLS2_k127_1391806_12 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000003669 222.0
TLS2_k127_1391806_13 - - - - 0.00000000000000000000000000000000008727 136.0
TLS2_k127_1391806_14 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000009917 90.0
TLS2_k127_1391806_2 dehydrogenase K00382 - 1.8.1.4 3.686e-194 615.0
TLS2_k127_1391806_3 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 588.0
TLS2_k127_1391806_4 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 544.0
TLS2_k127_1391806_5 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 496.0
TLS2_k127_1391806_6 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex K09699,K11273 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005947,GO:0009295,GO:0019899,GO:0030062,GO:0031625,GO:0031974,GO:0032991,GO:0042645,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044389,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0070013,GO:0098798,GO:1902494,GO:1990204 2.3.1.168,3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 479.0
TLS2_k127_1391806_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 459.0
TLS2_k127_1391806_8 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004624 441.0
TLS2_k127_1391806_9 ATPases associated with a variety of cellular activities K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 393.0
TLS2_k127_1406526_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 1.309e-199 627.0
TLS2_k127_1406526_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 466.0
TLS2_k127_1406526_2 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001219 260.0
TLS2_k127_1406526_3 COG0451 Nucleoside-diphosphate-sugar epimerases K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000178 181.0
TLS2_k127_1406526_4 - - - - 0.0000000009183 65.0
TLS2_k127_1406526_5 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00001595 48.0
TLS2_k127_1432899_0 Adenylate cyclase - - - 1.556e-263 821.0
TLS2_k127_1432899_1 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 375.0
TLS2_k127_1432899_2 conserved protein, contains double-stranded beta-helix domain - - - 0.000000000000000000000000000000000000000000000000000001346 196.0
TLS2_k127_1432899_3 - - - - 0.00000000000000002314 95.0
TLS2_k127_1432899_4 Binding-protein-dependent transport system inner membrane component - - - 0.000000002518 67.0
TLS2_k127_1432899_5 Domain of unknown function (DUF4142) K08995 - - 0.00000001475 66.0
TLS2_k127_1432899_6 Domain of unknown function (DUF4142) K08995 - - 0.0005353 51.0
TLS2_k127_1462565_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 2.542e-293 917.0
TLS2_k127_1462565_1 PFAM isocitrate isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 599.0
TLS2_k127_1462565_2 transport system fused permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 443.0
TLS2_k127_1462565_3 TRAP transporter solute receptor TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 439.0
TLS2_k127_1462565_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000704 427.0
TLS2_k127_1484279_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 0.0 1097.0
TLS2_k127_1484279_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.394e-271 849.0
TLS2_k127_1484279_10 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006041 355.0
TLS2_k127_1484279_11 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009467 311.0
TLS2_k127_1484279_12 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 305.0
TLS2_k127_1484279_13 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007878 302.0
TLS2_k127_1484279_14 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000293 238.0
TLS2_k127_1484279_15 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000000000000000000000000000000000008941 233.0
TLS2_k127_1484279_16 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000003773 211.0
TLS2_k127_1484279_17 Response regulator receiver K13589 - - 0.000000000000000000000000000000000000000000000000000000004011 205.0
TLS2_k127_1484279_18 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000000000000000000000000000002267 209.0
TLS2_k127_1484279_19 small integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000004542 193.0
TLS2_k127_1484279_2 reductase K00001,K14446 - 1.1.1.1,1.3.1.85 2.155e-257 799.0
TLS2_k127_1484279_20 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.00000000000000000000000000000000000000000000000005999 188.0
TLS2_k127_1484279_21 Domain of unknown function (DUF4167) - - - 0.000000000000000000000000000000000002622 149.0
TLS2_k127_1484279_23 Binds the 23S rRNA K02909 - - 0.0000000000000000000000000000003698 127.0
TLS2_k127_1484279_24 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950,K13940 - 2.7.6.3,4.1.2.25 0.00000000000000000000000000002213 124.0
TLS2_k127_1484279_25 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000001974 117.0
TLS2_k127_1484279_26 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000002001 85.0
TLS2_k127_1484279_27 Tetratricopeptide repeat - - - 0.000000000000005509 85.0
TLS2_k127_1484279_29 sequence-specific DNA binding - - - 0.0000004473 61.0
TLS2_k127_1484279_3 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 6.912e-235 741.0
TLS2_k127_1484279_30 Acetyltransferase, gnat family - - - 0.000002064 51.0
TLS2_k127_1484279_4 COG2873 O-acetylhomoserine sulfhydrylase - - - 1.797e-214 672.0
TLS2_k127_1484279_5 2-Nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 497.0
TLS2_k127_1484279_6 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 481.0
TLS2_k127_1484279_7 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009147 471.0
TLS2_k127_1484279_8 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 479.0
TLS2_k127_1484279_9 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008423 369.0
TLS2_k127_149558_0 succinate dehydrogenase fumarate reductase, flavoprotein subunit - - - 2.114e-216 685.0
TLS2_k127_149558_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K01665 - 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009492 613.0
TLS2_k127_149558_10 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009863 374.0
TLS2_k127_149558_11 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019,K18335 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 333.0
TLS2_k127_149558_12 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003278 328.0
TLS2_k127_149558_13 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006978 319.0
TLS2_k127_149558_14 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004424 257.0
TLS2_k127_149558_15 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000154 261.0
TLS2_k127_149558_16 Bacterial SH3 domain homologues K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000003518 195.0
TLS2_k127_149558_17 CoA-transferase family III - - - 0.0000000000000000000000000000003221 133.0
TLS2_k127_149558_2 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000808 537.0
TLS2_k127_149558_3 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 495.0
TLS2_k127_149558_4 Binding-protein-dependent transport system inner membrane component K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 484.0
TLS2_k127_149558_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 483.0
TLS2_k127_149558_6 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 463.0
TLS2_k127_149558_7 Binding-protein-dependent transport system inner membrane component K09971 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006184 462.0
TLS2_k127_149558_8 acid transport K09972 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 404.0
TLS2_k127_149558_9 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007728 395.0
TLS2_k127_1495912_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 5.4e-323 999.0
TLS2_k127_1495912_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 6.328e-204 647.0
TLS2_k127_1495912_2 Belongs to the UPF0061 (SELO) family K08997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 512.0
TLS2_k127_1495912_3 ABC-type branched-chain amino acid transport systems periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 412.0
TLS2_k127_1495912_4 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004594 377.0
TLS2_k127_1495912_5 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004167 357.0
TLS2_k127_1495912_6 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000007214 214.0
TLS2_k127_1495912_7 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000004991 177.0
TLS2_k127_1548103_0 Major Facilitator Superfamily - - - 7.942e-210 659.0
TLS2_k127_1548103_1 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 1.947e-208 668.0
TLS2_k127_1548103_2 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006142 509.0
TLS2_k127_1548103_3 beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 396.0
TLS2_k127_1548103_4 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003598 267.0
TLS2_k127_1548103_5 Ferric reductase like transmembrane component K17247 - - 0.0000000003574 62.0
TLS2_k127_1578220_0 - - - - 5.301e-239 754.0
TLS2_k127_1578220_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 485.0
TLS2_k127_1578220_2 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009547 451.0
TLS2_k127_1578220_3 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 329.0
TLS2_k127_1578220_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 318.0
TLS2_k127_1582291_0 ABC transporter K02471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 508.0
TLS2_k127_1582291_1 FMN-dependent dehydrogenase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 397.0
TLS2_k127_1582291_2 Mg chelatase subunit ChlI K07391 - - 0.0000000000000000000000000000000000000005853 149.0
TLS2_k127_1592117_0 Belongs to the HpcH HpaI aldolase family K01644,K08691 GO:0003674,GO:0003824,GO:0005488,GO:0016829,GO:0016830,GO:0016833,GO:0043167,GO:0043169,GO:0046872,GO:0047777,GO:0050083 4.1.3.24,4.1.3.25,4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 587.0
TLS2_k127_1592117_1 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 451.0
TLS2_k127_1592117_2 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 308.0
TLS2_k127_1592117_3 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006093 292.0
TLS2_k127_1592117_4 Methyltransferase domain - - - 0.000000000000000000000000000000003377 138.0
TLS2_k127_1592117_5 Efflux pump membrane transporter - - - 0.00000004774 55.0
TLS2_k127_1594141_0 Protein export membrane protein K18299,K18902 - - 0.0 1643.0
TLS2_k127_1594141_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion K18901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 430.0
TLS2_k127_1594141_2 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000000000000006444 231.0
TLS2_k127_1611089_0 Belongs to the ABC transporter superfamily K02031,K02032,K13896 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 1.973e-247 788.0
TLS2_k127_1611089_1 Binding-protein-dependent transport system inner membrane component K13895 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003981 579.0
TLS2_k127_1611089_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 516.0
TLS2_k127_1611089_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 486.0
TLS2_k127_1611089_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 404.0
TLS2_k127_1611089_5 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 404.0
TLS2_k127_1611089_6 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006477 245.0
TLS2_k127_1611089_7 binding-protein-dependent transport systems inner membrane component K13894 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - 0.00000000006879 62.0
TLS2_k127_166916_0 Dehydratase family K01687,K22186 - 4.2.1.82,4.2.1.9 2.887e-315 974.0
TLS2_k127_166916_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 9.476e-312 962.0
TLS2_k127_166916_10 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 322.0
TLS2_k127_166916_11 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000003376 243.0
TLS2_k127_166916_12 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000000000000000003606 235.0
TLS2_k127_166916_13 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000000000000000000000000000000000009162 202.0
TLS2_k127_166916_14 Thioesterase K07107 - - 0.0000000000000000000000000000000000001402 151.0
TLS2_k127_166916_15 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000179 117.0
TLS2_k127_166916_16 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000000000000002863 85.0
TLS2_k127_166916_2 Domain of unknown function (DUF4139) - - - 3.673e-249 790.0
TLS2_k127_166916_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 4.899e-225 703.0
TLS2_k127_166916_4 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 6.193e-205 646.0
TLS2_k127_166916_5 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 531.0
TLS2_k127_166916_6 AsmA family K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008129 553.0
TLS2_k127_166916_7 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 496.0
TLS2_k127_166916_8 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009687 346.0
TLS2_k127_166916_9 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009399 332.0
TLS2_k127_1701138_0 Histidine kinase K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 592.0
TLS2_k127_1701138_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 319.0
TLS2_k127_1701138_2 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003126 283.0
TLS2_k127_1701138_3 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002596 277.0
TLS2_k127_1701138_4 gag-polyprotein putative aspartyl protease K06985 - - 0.00000000000000000000000000000000000000000000000000000000000007459 224.0
TLS2_k127_1701138_5 gag-polyprotein putative aspartyl protease K06985 - - 0.0000000000000000000000000000000000008517 147.0
TLS2_k127_1701138_6 transaminase activity K00375,K01061 - 3.1.1.45 0.0000000000000003374 85.0
TLS2_k127_1701138_7 Protein of unknown function (DUF1289) K06938 - - 0.000000000003871 69.0
TLS2_k127_1701138_8 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0001929 48.0
TLS2_k127_1710127_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 4.259e-231 724.0
TLS2_k127_1710127_1 D-isomer specific 2-hydroxyacid dehydrogenase K00015 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 587.0
TLS2_k127_1710127_10 - - - - 0.00001071 56.0
TLS2_k127_1710127_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 381.0
TLS2_k127_1710127_3 recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 360.0
TLS2_k127_1710127_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 356.0
TLS2_k127_1710127_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 305.0
TLS2_k127_1710127_6 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000001335 218.0
TLS2_k127_1710127_7 Membrane transport protein K07088 - - 0.000000000000000000000000000002864 127.0
TLS2_k127_1710127_8 LysR substrate binding domain K03566 - - 0.00000000000000000001824 93.0
TLS2_k127_1874033_0 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 393.0
TLS2_k127_1874033_1 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 345.0
TLS2_k127_1874033_2 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 327.0
TLS2_k127_1874033_3 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000561 284.0
TLS2_k127_1874033_4 Methyltransferase small domain K15460 - 2.1.1.223 0.0000000000000000000000000000000000000000000000000000000000000005805 233.0
TLS2_k127_1874033_5 Redoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000003144 209.0
TLS2_k127_1874033_6 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000001675 121.0
TLS2_k127_1874033_7 Putative prokaryotic signal transducing protein - - - 0.00000000000000000108 89.0
TLS2_k127_1908890_0 glutamate--cysteine ligase K01919 - 6.3.2.2 4.477e-226 711.0
TLS2_k127_1908890_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 2.358e-208 650.0
TLS2_k127_1908890_10 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 361.0
TLS2_k127_1908890_11 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 353.0
TLS2_k127_1908890_12 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 322.0
TLS2_k127_1908890_13 Universal stress protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005698 302.0
TLS2_k127_1908890_14 Putative PD-(D/E)XK phosphodiesterase (DUF2161) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 287.0
TLS2_k127_1908890_15 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000003081 212.0
TLS2_k127_1908890_16 - K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.000000000000000000000000000000000000000001059 160.0
TLS2_k127_1908890_17 methyltransferase - - - 0.0000000000003743 73.0
TLS2_k127_1908890_2 COG0477 Permeases of the major facilitator superfamily - - - 7.714e-206 646.0
TLS2_k127_1908890_3 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 608.0
TLS2_k127_1908890_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 538.0
TLS2_k127_1908890_5 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 534.0
TLS2_k127_1908890_6 AMP-binding enzyme C-terminal domain K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005555 531.0
TLS2_k127_1908890_7 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 509.0
TLS2_k127_1908890_8 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 467.0
TLS2_k127_1908890_9 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006499 406.0
TLS2_k127_1919187_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046,K13797 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2337.0
TLS2_k127_1919187_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1043.0
TLS2_k127_1919187_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 591.0
TLS2_k127_1919187_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006214 364.0
TLS2_k127_1919187_4 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000003425 161.0
TLS2_k127_1919187_5 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.000000000000000000000000000006912 131.0
TLS2_k127_1936109_0 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006646 522.0
TLS2_k127_1936109_1 Sulfide dehydrogenase K17218,K17229 - 1.8.2.3,1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000083 440.0
TLS2_k127_1936109_2 Iron-containing alcohol dehydrogenase K00217 - 1.3.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000004444 254.0
TLS2_k127_1936109_3 Sulfur oxidation protein SoxY K17226 - - 0.000000000000000000000000000000000001755 145.0
TLS2_k127_1936109_4 oxidation protein (SoxZ) K17227 - - 0.000000000000000000000000000000000009123 138.0
TLS2_k127_1936109_5 - - - - 0.0000000000000000000000000000000003945 137.0
TLS2_k127_1936109_6 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000000258 131.0
TLS2_k127_1936109_7 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.00000000000000000000000004204 108.0
TLS2_k127_1936109_8 Regulatory protein SoxS - - - 0.00000000000000000002022 97.0
TLS2_k127_1956715_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00018,K00058 - 1.1.1.29,1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 554.0
TLS2_k127_1956715_1 - - - - 0.000000000000000000000000000000000000000000000000000000006081 222.0
TLS2_k127_1965586_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 1.071e-287 900.0
TLS2_k127_1965586_1 Zinc-binding dehydrogenase K19745 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005451 472.0
TLS2_k127_1965586_10 - - - - 0.000000000000009873 80.0
TLS2_k127_1965586_12 Rod binding protein - - - 0.0000000005743 66.0
TLS2_k127_1965586_14 - - - - 0.00000001078 63.0
TLS2_k127_1965586_15 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02397 - - 0.00000009838 55.0
TLS2_k127_1965586_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 287.0
TLS2_k127_1965586_3 cytolysis by virus of host cell K01185 - 3.2.1.17 0.00000000000000000000000000000000000000000000000004182 189.0
TLS2_k127_1965586_4 Role in flagellar biosynthesis K02421 - - 0.0000000000000000000000000000000000000000006467 169.0
TLS2_k127_1965586_5 Flagellar protein FlbT K06601 - - 0.00000000000000000000000000000000000495 142.0
TLS2_k127_1965586_6 Flagellar hook capping protein K02389 - - 0.00000000000000000000000001275 116.0
TLS2_k127_1965586_7 - - - - 0.00000000000000000000000001443 112.0
TLS2_k127_1965586_8 Flagellar protein FlaF K06602 - - 0.000000000000000000000006182 105.0
TLS2_k127_1965586_9 Flagellar biosynthetic protein FliQ K02420 - - 0.000000000000000000002374 104.0
TLS2_k127_2001236_0 transport system fused permease components - - - 0.0 1262.0
TLS2_k127_2001236_1 oxidase, subunit K00425 - 1.10.3.14 1.703e-261 811.0
TLS2_k127_2001236_10 Protein of unknown function (DUF1428) - - - 0.0000000000000000000000000000000000000000000000000000004094 208.0
TLS2_k127_2001236_11 Cupin domain - - - 0.0000000000000000000000000000000000000000000000007798 177.0
TLS2_k127_2001236_12 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.000000000000000000000000000000000000002605 153.0
TLS2_k127_2001236_13 COG0076 Glutamate decarboxylase and related PLP-dependent proteins K01634 - 4.1.2.27 0.0009065 44.0
TLS2_k127_2001236_2 Gamma-glutamyltranspeptidase - - - 3.276e-218 695.0
TLS2_k127_2001236_3 Cytochrome BD ubiquinol oxidase subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007097 579.0
TLS2_k127_2001236_4 NMT1-like family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 533.0
TLS2_k127_2001236_5 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 332.0
TLS2_k127_2001236_6 Amidohydrolase K07045,K14333,K15063 - 4.1.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006046 317.0
TLS2_k127_2001236_7 PFAM Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000043 248.0
TLS2_k127_2001236_8 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.0000000000000000000000000000000000000000000000000000000000000000939 231.0
TLS2_k127_2001236_9 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000001952 204.0
TLS2_k127_2009126_0 succinate dehydrogenase fumarate reductase, flavoprotein subunit K00394 - 1.8.99.2 0.0 1040.0
TLS2_k127_2009126_1 AMP-binding enzyme C-terminal domain K00666 - - 2.716e-224 705.0
TLS2_k127_2009126_10 TIGRFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 404.0
TLS2_k127_2009126_11 Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate) K19268 - 5.4.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 404.0
TLS2_k127_2009126_12 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 362.0
TLS2_k127_2009126_13 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 360.0
TLS2_k127_2009126_14 Enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 353.0
TLS2_k127_2009126_15 AAA domain K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006054 337.0
TLS2_k127_2009126_16 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 321.0
TLS2_k127_2009126_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008877 291.0
TLS2_k127_2009126_18 reductase, beta subunit K00395 - 1.8.99.2 0.00000000000000000000000000000000000000000000000000000000000000000008843 233.0
TLS2_k127_2009126_19 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000001661 217.0
TLS2_k127_2009126_2 Periplasmic binding protein domain K01999 - - 6.74e-206 650.0
TLS2_k127_2009126_20 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000003108 198.0
TLS2_k127_2009126_21 Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate) K01846 - 5.4.99.1 0.00000000000000000000000000000000000000000000001986 176.0
TLS2_k127_2009126_22 e3 binding domain - - - 0.000000000000000000000000000000000000009388 158.0
TLS2_k127_2009126_23 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.0000000000000000000000000000000000152 145.0
TLS2_k127_2009126_24 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000009851 94.0
TLS2_k127_2009126_25 PFAM Short-chain dehydrogenase reductase SDR K00034,K00059 - 1.1.1.100,1.1.1.47 0.000000006053 64.0
TLS2_k127_2009126_26 PFAM Transposase K07491 - - 0.00005153 47.0
TLS2_k127_2009126_3 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005391 575.0
TLS2_k127_2009126_4 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004571 571.0
TLS2_k127_2009126_5 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 527.0
TLS2_k127_2009126_6 Transketolase, pyrimidine binding domain K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008682 492.0
TLS2_k127_2009126_7 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008588 414.0
TLS2_k127_2009126_8 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 419.0
TLS2_k127_2009126_9 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 406.0
TLS2_k127_2029465_0 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 1.674e-236 739.0
TLS2_k127_2029465_1 FAD-dependent oxidoreductase K05712 - 1.14.13.127 1.319e-219 694.0
TLS2_k127_2029465_10 Protein of unknown function (DUF2783) - - - 0.000000000009878 69.0
TLS2_k127_2029465_11 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000003571 52.0
TLS2_k127_2029465_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 9.41e-213 667.0
TLS2_k127_2029465_3 Enoyl-CoA hydratase/isomerase K15513 - 4.1.2.44 1.068e-211 669.0
TLS2_k127_2029465_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 543.0
TLS2_k127_2029465_5 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 339.0
TLS2_k127_2029465_6 Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009008 293.0
TLS2_k127_2029465_7 COG2801 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008878 252.0
TLS2_k127_2029465_8 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000000000000000000000000000008181 224.0
TLS2_k127_2029465_9 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000002427 110.0
TLS2_k127_2044276_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 501.0
TLS2_k127_2044276_1 pyridine nucleotide-disulfide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 432.0
TLS2_k127_2044276_2 Cadherin-like - - - 0.000000000000000000000000000000000000000000000000000000000000007301 223.0
TLS2_k127_2044276_3 Resolvase - - - 0.00000000001328 65.0
TLS2_k127_2044276_4 DNA integration - - - 0.0000003413 53.0
TLS2_k127_2045302_0 helicase superfamily c-terminal domain K17675 - 3.6.4.13 0.0 1273.0
TLS2_k127_2045302_1 Domain of unknown function (DUF1974) K06445 - - 0.0 1245.0
TLS2_k127_2045302_10 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 442.0
TLS2_k127_2045302_11 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 419.0
TLS2_k127_2045302_12 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 363.0
TLS2_k127_2045302_13 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 355.0
TLS2_k127_2045302_14 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 307.0
TLS2_k127_2045302_15 glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005534 285.0
TLS2_k127_2045302_16 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003595 283.0
TLS2_k127_2045302_17 import inner membrane translocase subunit Tim44 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006 269.0
TLS2_k127_2045302_18 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001142 276.0
TLS2_k127_2045302_19 hydrolases of HD superfamily K06952 - - 0.000000000000000000000000000000000000000000000000000000000000000000001224 242.0
TLS2_k127_2045302_2 Belongs to the enoyl-CoA hydratase isomerase family K01782,K01825 - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 1.233e-303 943.0
TLS2_k127_2045302_20 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000002806 192.0
TLS2_k127_2045302_21 Putative member of DMT superfamily (DUF486) K09922 - - 0.000000000000000000000000000000000000000000000003467 175.0
TLS2_k127_2045302_22 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000005587 173.0
TLS2_k127_2045302_23 Hint domain - - - 0.000000000000000000000000000000000000000005737 164.0
TLS2_k127_2045302_24 S4 domain K04762 - - 0.0000000000000000000000000000000000009402 145.0
TLS2_k127_2045302_25 Smr domain - - - 0.000000000000000000000000000000000001532 147.0
TLS2_k127_2045302_26 Small Multidrug Resistance protein K03297 - - 0.000000000000000000000000000000003131 133.0
TLS2_k127_2045302_27 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000004129 112.0
TLS2_k127_2045302_28 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000004366 108.0
TLS2_k127_2045302_3 Bacterial membrane protein, YfhO - - - 3.951e-256 814.0
TLS2_k127_2045302_30 Protein affecting phage T7 exclusion by the F plasmid K07113 - - 0.00000000000000001009 89.0
TLS2_k127_2045302_31 Tripartite tricarboxylate transporter TctB family K07794 - - 0.00000000000001695 83.0
TLS2_k127_2045302_32 - - - - 0.0000001536 53.0
TLS2_k127_2045302_33 - - - - 0.000005238 51.0
TLS2_k127_2045302_4 Tripartite tricarboxylate transporter TctA family K07793 - - 9.899e-243 762.0
TLS2_k127_2045302_5 Amidohydrolase family K01465 - 3.5.2.3 7.878e-221 694.0
TLS2_k127_2045302_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.09e-207 664.0
TLS2_k127_2045302_7 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 486.0
TLS2_k127_2045302_8 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 451.0
TLS2_k127_2045302_9 MltA specific insert domain K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 455.0
TLS2_k127_204625_0 Serine dehydrogenase proteinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008454 341.0
TLS2_k127_204625_1 PFAM peptidase U6 penicillin-insensitive murein endopeptidase K07261 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 349.0
TLS2_k127_204625_2 CsbD-like - - - 0.000000000000000000000000000004205 119.0
TLS2_k127_204625_3 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000009584 54.0
TLS2_k127_204625_4 PRC-barrel domain - - - 0.00001138 54.0
TLS2_k127_204625_5 PFAM response regulator receiver K07659 - - 0.0001482 51.0
TLS2_k127_2066347_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1255.0
TLS2_k127_2066347_1 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 2.637e-310 957.0
TLS2_k127_2066347_10 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001617 255.0
TLS2_k127_2066347_11 Protein of unknown function (DUF1223) - - - 0.0000000000000000000000000000000000000000000000000003069 197.0
TLS2_k127_2066347_12 SOS response K14160 - - 0.0000000000000000000004581 109.0
TLS2_k127_2066347_2 Belongs to the ABC transporter superfamily K02031,K02032 - - 4.124e-276 865.0
TLS2_k127_2066347_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 3.429e-246 773.0
TLS2_k127_2066347_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008329 617.0
TLS2_k127_2066347_5 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 547.0
TLS2_k127_2066347_6 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 490.0
TLS2_k127_2066347_7 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008434 436.0
TLS2_k127_2066347_8 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 405.0
TLS2_k127_2066347_9 COG0389 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 368.0
TLS2_k127_2068567_0 GTA TIM-barrel-like domain - - - 0.0 1495.0
TLS2_k127_2068567_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 527.0
TLS2_k127_2068567_2 Glycosyl hydrolase 108 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 413.0
TLS2_k127_2068567_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000005213 226.0
TLS2_k127_2068567_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000124 136.0
TLS2_k127_2083270_0 SpoVR like protein K06415 - - 1.417e-207 659.0
TLS2_k127_2083270_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 579.0
TLS2_k127_2083270_2 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 565.0
TLS2_k127_2083270_3 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 550.0
TLS2_k127_2083270_4 Belongs to the UPF0229 family K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 453.0
TLS2_k127_2083270_5 PrkA AAA domain K07180 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006649 399.0
TLS2_k127_2083270_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 340.0
TLS2_k127_2083270_7 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000001148 153.0
TLS2_k127_208755_0 Flavin-binding monooxygenase-like K03379,K21730 - 1.14.13.160,1.14.13.22 5.83e-278 864.0
TLS2_k127_208755_1 Proton-conducting membrane transporter K00341,K05568 - 1.6.5.3 2.768e-196 629.0
TLS2_k127_208755_10 hydrolase K16171 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 299.0
TLS2_k127_208755_11 Stress-induced protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001003 285.0
TLS2_k127_208755_12 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009386 266.0
TLS2_k127_208755_13 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001308 248.0
TLS2_k127_208755_14 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000009312 255.0
TLS2_k127_208755_15 Glutathione-dependent formaldehyde-activating enzyme family protein 4 - - - 0.00000000000000000000000000000000000000000000000000000000009292 208.0
TLS2_k127_208755_16 Domain of unknown function (DUF4040) K05566 - - 0.00000000000000000000000000000000000000000000000000000001163 203.0
TLS2_k127_208755_17 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000000000000000000009866 183.0
TLS2_k127_208755_18 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.00000000000000000000000000000000000000000000000001915 184.0
TLS2_k127_208755_19 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000001809 186.0
TLS2_k127_208755_2 Luciferase-like monooxygenase - - - 7.861e-196 621.0
TLS2_k127_208755_20 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 - 4.1.1.79 0.0000000000000000000000000000000000000000000000003457 181.0
TLS2_k127_208755_21 - - - - 0.00000000000000000000000000000000000000000000006222 175.0
TLS2_k127_208755_22 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000000001178 173.0
TLS2_k127_208755_23 COG1006 Multisubunit Na H antiporter, MnhC subunit K05567 - - 0.000000000000000000000000000000000000000006751 163.0
TLS2_k127_208755_24 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000001701 162.0
TLS2_k127_208755_25 Na+/H+ ion antiporter subunit K05569 - - 0.0000000000000000000000000000000000001355 147.0
TLS2_k127_208755_26 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000361 126.0
TLS2_k127_208755_27 Na+/H+ antiporter subunit K05571 - - 0.0000000000000000000000000008978 119.0
TLS2_k127_208755_28 phosphatase - - - 0.00000000000000000000000003471 117.0
TLS2_k127_208755_29 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.000000000000000000000001206 106.0
TLS2_k127_208755_3 Proton-conducting membrane transporter K00343,K05568 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 582.0
TLS2_k127_208755_30 - - - - 0.0000003906 61.0
TLS2_k127_208755_4 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 567.0
TLS2_k127_208755_5 Orn DAP Arg decarboxylase 2 K01581 - 4.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007403 550.0
TLS2_k127_208755_6 RNA polymerase sigma factor RpoH K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 463.0
TLS2_k127_208755_7 NADH flavin oxidoreductase NADH oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 414.0
TLS2_k127_208755_8 Aldolase/RraA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 379.0
TLS2_k127_208755_9 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 323.0
TLS2_k127_2088669_0 Belongs to the binding-protein-dependent transport system permease family K11960 - - 1.714e-200 639.0
TLS2_k127_2088669_1 Belongs to the binding-protein-dependent transport system permease family K11961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 575.0
TLS2_k127_2088669_2 Branched-chain amino acid ATP-binding cassette transporter K11962 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 361.0
TLS2_k127_2088669_3 ATPases associated with a variety of cellular activities K11963 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 347.0
TLS2_k127_2088669_4 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000002178 123.0
TLS2_k127_2093294_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1038.0
TLS2_k127_2093294_1 Tetratricopeptide repeat - - - 8.846e-196 627.0
TLS2_k127_2093294_2 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000003352 247.0
TLS2_k127_2093294_3 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000008696 111.0
TLS2_k127_2093294_4 Uncharacterized protein conserved in bacteria (DUF2093) - - - 0.00000000000000000000002857 109.0
TLS2_k127_2093294_5 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000001108 69.0
TLS2_k127_2095056_0 CoA binding domain K09181 - - 4.413e-317 993.0
TLS2_k127_2095056_1 Belongs to the heme-copper respiratory oxidase family K00404 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 2.893e-292 903.0
TLS2_k127_2095056_10 ATPases associated with a variety of cellular activities K02003,K05685 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 335.0
TLS2_k127_2095056_11 ABC-type transport auxiliary lipoprotein component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 323.0
TLS2_k127_2095056_12 Two component transcriptional regulator, winged helix family K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 299.0
TLS2_k127_2095056_13 PHB de-polymerase C-terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 300.0
TLS2_k127_2095056_14 Transcriptional regulator, Crp Fnr family K01420,K15861 - - 0.000000000000000000000000000000000000000000000000000004035 199.0
TLS2_k127_2095056_15 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000008277 187.0
TLS2_k127_2095056_16 pyridine nucleotide-disulfide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000531 128.0
TLS2_k127_2095056_17 Uncharacterized conserved protein (DUF2267) - - - 0.0000000000000000000000004184 106.0
TLS2_k127_2095056_18 - - - - 0.000000000000134 72.0
TLS2_k127_2095056_19 Uncharacterized conserved protein (DUF2267) - - - 0.0000000000005491 74.0
TLS2_k127_2095056_2 Cytochrome C oxidase accessory protein CcoG - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009106 613.0
TLS2_k127_2095056_20 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000002701 67.0
TLS2_k127_2095056_21 Phosphotransferase enzyme family K07028 - - 0.00000001012 63.0
TLS2_k127_2095056_22 AAA domain K07028 - - 0.0000003951 59.0
TLS2_k127_2095056_23 - - - - 0.0000006023 54.0
TLS2_k127_2095056_24 PFAM Cbb3-type cytochrome oxidase component K00407 - - 0.000003815 50.0
TLS2_k127_2095056_25 Protein required for attachment to host cells - - - 0.00001442 49.0
TLS2_k127_2095056_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 597.0
TLS2_k127_2095056_4 HlyD family secretion protein K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005831 489.0
TLS2_k127_2095056_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 474.0
TLS2_k127_2095056_6 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 464.0
TLS2_k127_2095056_7 cytochrome C K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008635 388.0
TLS2_k127_2095056_8 ATPases associated with a variety of cellular activities K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000442 376.0
TLS2_k127_2095056_9 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 375.0
TLS2_k127_2104690_0 Extracellular solute-binding protein K13893 - - 3.508e-253 794.0
TLS2_k127_2104690_1 Bacterial extracellular solute-binding proteins, family 5 Middle K13893 - - 1.098e-228 724.0
TLS2_k127_2104690_2 binding-protein-dependent transport systems inner membrane component K13894 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005934 589.0
TLS2_k127_2104690_3 cytochrome K08738 - - 0.00000000000000000000000000000000000000000000001032 176.0
TLS2_k127_2134723_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 1.535e-245 764.0
TLS2_k127_2134723_1 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 444.0
TLS2_k127_2134723_2 - - - - 0.0000000000000001689 85.0
TLS2_k127_2134723_4 Domain of unknown function (DUF4167) - - - 0.0007529 46.0
TLS2_k127_2138361_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 3.901e-247 779.0
TLS2_k127_2138361_1 Belongs to the beta-ketoacyl-ACP synthases family K14660 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 593.0
TLS2_k127_2138361_10 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000007159 234.0
TLS2_k127_2138361_11 Phosphopantetheine attachment site K02078,K14661 - - 0.0000000000000000000000000000000000002261 143.0
TLS2_k127_2138361_12 Bacterial SH3 domain - - - 0.000000000009138 73.0
TLS2_k127_2138361_13 Bacterial SH3 domain homologues - - - 0.0001963 51.0
TLS2_k127_2138361_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 543.0
TLS2_k127_2138361_3 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 471.0
TLS2_k127_2138361_4 COG1960 Acyl-CoA dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 407.0
TLS2_k127_2138361_5 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 347.0
TLS2_k127_2138361_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 295.0
TLS2_k127_2138361_7 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006931 281.0
TLS2_k127_2138361_8 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000007491 253.0
TLS2_k127_2138361_9 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000002133 241.0
TLS2_k127_2162045_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009037 567.0
TLS2_k127_2162045_1 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 509.0
TLS2_k127_2162045_10 helix-turn-helix domain protein - - - 0.000000000116 72.0
TLS2_k127_2162045_11 Acyl-CoA dehydrogenase, C-terminal domain K00249,K00255 - 1.3.8.7,1.3.8.8 0.00000002635 55.0
TLS2_k127_2162045_2 Domain of unknown function (4846) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002091 287.0
TLS2_k127_2162045_3 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000007189 216.0
TLS2_k127_2162045_4 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000751 200.0
TLS2_k127_2162045_5 Protein of unknown function (DUF1428) - - - 0.000000000000000000000000000000000000000000000262 169.0
TLS2_k127_2162045_6 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000004921 184.0
TLS2_k127_2162045_7 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000326 156.0
TLS2_k127_2162045_8 ThiS family - - - 0.000000000000000000000000001651 117.0
TLS2_k127_2162045_9 KR domain - - - 0.0000000000299 68.0
TLS2_k127_219723_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006405 462.0
TLS2_k127_219723_1 Zeta toxin K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 458.0
TLS2_k127_219723_10 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000557 89.0
TLS2_k127_219723_2 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 421.0
TLS2_k127_219723_3 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 397.0
TLS2_k127_219723_4 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 314.0
TLS2_k127_219723_5 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 298.0
TLS2_k127_219723_6 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002539 245.0
TLS2_k127_219723_7 PFAM EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002827 245.0
TLS2_k127_219723_8 MaoC like domain - - - 0.0000000000000000000000000000000000000000000000000000000000001416 216.0
TLS2_k127_219723_9 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000002966 137.0
TLS2_k127_2258132_0 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 399.0
TLS2_k127_2258132_1 Putative S-adenosyl-L-methionine-dependent methyltransferase K00574,K18164 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 347.0
TLS2_k127_2258132_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 313.0
TLS2_k127_2258132_3 Protein of unknown function (DUF1214) - - - 0.0000000000000000000000000000000000000000000000000002485 191.0
TLS2_k127_2258132_4 Protein of unknown function (DUF1254) - - - 0.00000000000002216 81.0
TLS2_k127_2262095_0 Alkyl sulfatase dimerisation - - - 1.242e-280 876.0
TLS2_k127_2262095_1 class II (D K and N) K04568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009992 510.0
TLS2_k127_2262095_2 Lysine-2,3-aminomutase K01843 - 5.4.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 402.0
TLS2_k127_2262095_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 301.0
TLS2_k127_2308204_0 GMC oxidoreductase K03333 - 1.1.3.6 3.475e-305 969.0
TLS2_k127_2308204_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 2.452e-203 647.0
TLS2_k127_2308204_2 Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily K13747 - 4.1.1.96 1.407e-197 621.0
TLS2_k127_2308204_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 319.0
TLS2_k127_2308204_4 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 310.0
TLS2_k127_2308204_5 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0002799 46.0
TLS2_k127_2320507_0 Carbamoyl-phosphate synthase L chain ATP-binding K01965 GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681 6.4.1.3 0.0 1047.0
TLS2_k127_2320507_1 Biotin carboxylase K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 1.144e-257 802.0
TLS2_k127_2320507_10 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.0000000000000000000000000000000000000000000000003807 184.0
TLS2_k127_2320507_11 Hint domain - - - 0.0000000000000000000000000000000000000000005066 168.0
TLS2_k127_2320507_12 AraC-like ligand binding domain - - - 0.0000000000000000000000000006682 116.0
TLS2_k127_2320507_13 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000149 95.0
TLS2_k127_2320507_2 benzoyl-CoA oxygenase K15511 - 1.14.13.208 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 518.0
TLS2_k127_2320507_3 Peptidase M48 Ste24p - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 460.0
TLS2_k127_2320507_4 KR domain K00059,K07535 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 323.0
TLS2_k127_2320507_5 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001856 280.0
TLS2_k127_2320507_6 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003836 268.0
TLS2_k127_2320507_7 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000193 216.0
TLS2_k127_2320507_8 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000002099 210.0
TLS2_k127_2320507_9 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.00000000000000000000000000000000000000000000000002203 181.0
TLS2_k127_233726_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 8.099e-251 778.0
TLS2_k127_233726_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 524.0
TLS2_k127_233726_10 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000001192 74.0
TLS2_k127_233726_11 - - - - 0.0000004138 61.0
TLS2_k127_233726_2 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 487.0
TLS2_k127_233726_3 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 411.0
TLS2_k127_233726_4 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 367.0
TLS2_k127_233726_5 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 352.0
TLS2_k127_233726_6 helix_turn_helix ASNC type K05800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001805 256.0
TLS2_k127_233726_8 Cytochrome c - - - 0.00000000000000000000004642 102.0
TLS2_k127_233726_9 Protein conserved in bacteria - - - 0.000000000000000000002009 101.0
TLS2_k127_2357456_0 Adenylate cyclase - - - 1.319e-268 842.0
TLS2_k127_2357456_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 555.0
TLS2_k127_2357456_2 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 462.0
TLS2_k127_2357456_3 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009125 426.0
TLS2_k127_2357456_4 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 320.0
TLS2_k127_2357456_5 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 331.0
TLS2_k127_2357456_6 Beta-lactamase K18372 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002244 240.0
TLS2_k127_2357456_7 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000007377 231.0
TLS2_k127_2362476_0 acetyl-coa acetyltransferase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004591 533.0
TLS2_k127_2362476_1 Dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 445.0
TLS2_k127_2362476_10 succinate dehydrogenase K00246 - - 0.0000000000000000000000000000938 121.0
TLS2_k127_2362476_11 succinate dehydrogenase K00247 - - 0.00000000000000000000000009731 119.0
TLS2_k127_2362476_2 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004919 444.0
TLS2_k127_2362476_3 Succinate dehydrogenase Fumarate reductase K00245 - 1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 345.0
TLS2_k127_2362476_4 Belongs to the SfsA family K06206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 321.0
TLS2_k127_2362476_5 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01031 - 2.8.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009285 321.0
TLS2_k127_2362476_6 Coenzyme A transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004299 304.0
TLS2_k127_2362476_7 Mo-co oxidoreductase dimerisation domain K17225 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003579 256.0
TLS2_k127_2362476_8 Tim44 - - - 0.000000000000000000000000000000000000000000000000000000000000000001066 239.0
TLS2_k127_2362476_9 Responsible for synthesis of pseudouridine from uracil K06179 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 0.000000000000000000000000000000000000000001135 158.0
TLS2_k127_2409155_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 8.447e-248 775.0
TLS2_k127_2409155_1 N-terminal domain of unknown function (DUF4140) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 546.0
TLS2_k127_2409155_2 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 316.0
TLS2_k127_2409155_3 inositol mono-phosphatase K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 291.0
TLS2_k127_2437049_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0 1452.0
TLS2_k127_2437049_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00244 - 1.3.5.4 1.533e-271 845.0
TLS2_k127_2437049_10 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 314.0
TLS2_k127_2437049_11 Uncharacterized protein conserved in bacteria (DUF2325) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001332 262.0
TLS2_k127_2437049_12 GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006908 233.0
TLS2_k127_2437049_13 Serine hydrolase K07002 - - 0.000000000000000000000000000000000000000000000000000000000000004334 223.0
TLS2_k127_2437049_14 PFAM Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000002365 192.0
TLS2_k127_2437049_15 gamma-carboxymuconolactone decarboxylase subunit K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000001893 179.0
TLS2_k127_2437049_16 Vibrio cholerae RfbT protein - - - 0.0000000000000000000000000000000000000001084 161.0
TLS2_k127_2437049_17 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000001334 156.0
TLS2_k127_2437049_18 - - - - 0.00000000000000000000000000000000000004231 149.0
TLS2_k127_2437049_19 transcriptional regulator K13771,K13772 - - 0.00000000000000000000000000000003229 132.0
TLS2_k127_2437049_2 Acyl-CoA synthetase K00666,K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 612.0
TLS2_k127_2437049_20 Chorismate mutase, type II K04782 - 4.2.99.21 0.000000000000000000000000000001717 130.0
TLS2_k127_2437049_21 Protein of unknown function (DUF2628) - - - 0.000000000000000000000000000002503 126.0
TLS2_k127_2437049_23 BFD-like [2Fe-2S] binding domain - - - 0.000000000000000000000000006118 112.0
TLS2_k127_2437049_24 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases. - - - 0.00000000000000000000003661 114.0
TLS2_k127_2437049_25 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000002549 72.0
TLS2_k127_2437049_26 Hemin uptake protein - - - 0.0000002485 59.0
TLS2_k127_2437049_27 - - - - 0.00004446 49.0
TLS2_k127_2437049_3 Chorismate synthase K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 605.0
TLS2_k127_2437049_4 extracellular polysaccharide biosynthetic process K16554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 608.0
TLS2_k127_2437049_5 Malate/L-lactate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 535.0
TLS2_k127_2437049_6 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 434.0
TLS2_k127_2437049_7 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 413.0
TLS2_k127_2437049_8 imidazoleglycerol-phosphate dehydratase K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 344.0
TLS2_k127_2437049_9 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 333.0
TLS2_k127_2441781_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 8.729e-265 836.0
TLS2_k127_2441781_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 420.0
TLS2_k127_2459308_0 Homocysteine S-methyltransferase K00544,K00548 - 2.1.1.13,2.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 582.0
TLS2_k127_2459308_1 Methylenetetrahydrofolate reductase K00297 GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 488.0
TLS2_k127_2459308_2 FAD binding domain K03185 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 439.0
TLS2_k127_2459308_3 acyl-CoA thioesterase K10805 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 411.0
TLS2_k127_2459308_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008668 405.0
TLS2_k127_2459308_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 378.0
TLS2_k127_2459308_6 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 336.0
TLS2_k127_2459308_7 Belongs to the P(II) protein family K04751,K04752 - - 0.000000000000000000000000000000000000000000000000000001706 194.0
TLS2_k127_2459308_8 Methyltransferase FkbM domain - - - 0.0001757 52.0
TLS2_k127_2491326_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.4e-291 908.0
TLS2_k127_2491326_1 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685 - 4.2.1.7 9.625e-254 790.0
TLS2_k127_2491326_10 COG1414 Transcriptional regulator K02624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005943 280.0
TLS2_k127_2491326_11 GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008183 271.0
TLS2_k127_2491326_12 synthesis repressor PhaR - - - 0.000000000000000000000000000000000000000000000000000000000000000000006813 243.0
TLS2_k127_2491326_13 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002068 235.0
TLS2_k127_2491326_14 NADH ubiquinone oxidoreductase 17.2 kD subunit K00356 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000005514 222.0
TLS2_k127_2491326_15 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000000000000000000000000001186 220.0
TLS2_k127_2491326_16 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000001245 219.0
TLS2_k127_2491326_17 Phosphoribosyl-AMP cyclohydrolase K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000001994 190.0
TLS2_k127_2491326_18 COG0822 NifU homolog involved in Fe-S cluster formation - - - 0.00000000000000000000000000000000000000000000000004599 183.0
TLS2_k127_2491326_19 PFAM Cupin domain - - - 0.00000000000000000000000000000000000000000000003604 173.0
TLS2_k127_2491326_2 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 3.674e-210 661.0
TLS2_k127_2491326_20 DsrE/DsrF-like family K09004 - - 0.00000000000000000000000000000000000000000008149 168.0
TLS2_k127_2491326_21 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.0000000000000000000000000000000000000000007963 167.0
TLS2_k127_2491326_22 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000000000000000000008353 150.0
TLS2_k127_2491326_23 Protein of unknown function (DUF2794) - - - 0.00000000000000000000000000000000000002247 150.0
TLS2_k127_2491326_24 - - - - 0.000000000000000000000000000001541 125.0
TLS2_k127_2491326_25 Transcriptional activator HlyU - - - 0.0000000000000000000000002728 108.0
TLS2_k127_2491326_26 Ribbon-helix-helix domain - - - 0.0000000000000000000000137 104.0
TLS2_k127_2491326_27 COG0790 FOG TPR repeat, SEL1 subfamily - - - 0.0000000000004337 81.0
TLS2_k127_2491326_28 His Kinase A (phosphoacceptor) domain - - - 0.000000002481 65.0
TLS2_k127_2491326_29 Domain of unknown function (DUF4169) - - - 0.000000008114 61.0
TLS2_k127_2491326_3 Thiolase, C-terminal domain K00626 - 2.3.1.9 5.515e-199 626.0
TLS2_k127_2491326_4 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 535.0
TLS2_k127_2491326_5 Probable molybdopterin binding domain K07141 - 2.7.7.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 522.0
TLS2_k127_2491326_6 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 515.0
TLS2_k127_2491326_7 KR domain K00023 - 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 370.0
TLS2_k127_2491326_8 NMT1-like family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 360.0
TLS2_k127_2491326_9 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 323.0
TLS2_k127_2545888_0 TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 581.0
TLS2_k127_2545888_1 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 551.0
TLS2_k127_2545888_2 Amino-transferase class IV K00824 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 379.0
TLS2_k127_2545888_3 Peptidase family M50 K06402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006543 284.0
TLS2_k127_2545888_4 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000005756 213.0
TLS2_k127_26045_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1146.0
TLS2_k127_26045_1 Involved in Beta-(1-- 2)glucan export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP- binding domain (NBD) is responsible for energy generation K06147 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - 1.888e-220 704.0
TLS2_k127_26045_10 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000483 240.0
TLS2_k127_26045_11 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000000004288 235.0
TLS2_k127_26045_12 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000000221 205.0
TLS2_k127_26045_13 Putative tRNA binding domain K06878 GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000281 190.0
TLS2_k127_26045_14 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000008659 168.0
TLS2_k127_26045_2 Signal transduction histidine kinase K07638 - 2.7.13.3 3.195e-201 637.0
TLS2_k127_26045_3 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 516.0
TLS2_k127_26045_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009396 427.0
TLS2_k127_26045_5 Two component transcriptional regulator K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 349.0
TLS2_k127_26045_6 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009378 344.0
TLS2_k127_26045_7 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 319.0
TLS2_k127_26045_8 Ribonuclease, BN K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008265 275.0
TLS2_k127_26045_9 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000003611 252.0
TLS2_k127_261166_0 SNF2 family N-terminal domain - - - 0.00000000000000000000000000000000000000000000000001698 183.0
TLS2_k127_261166_1 - - - - 0.000000000000000000000000000000000000001835 158.0
TLS2_k127_261166_2 - - - - 0.000000000000000000000000000002156 126.0
TLS2_k127_261166_3 - - - - 0.000000000004156 70.0
TLS2_k127_261166_4 PFAM transposase IS4 family protein - - - 0.00000000005904 68.0
TLS2_k127_261166_5 - - - - 0.0000000006353 68.0
TLS2_k127_261166_6 PFAM Integrase catalytic region - - - 0.00002939 48.0
TLS2_k127_26226_0 Circularly permuted ATP-grasp type 2 - - - 5.935e-225 709.0
TLS2_k127_26226_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006646 522.0
TLS2_k127_26226_10 Tetratricopeptide repeat K03671,K05838 - - 0.0000000000000000000000000000002032 125.0
TLS2_k127_26226_11 Belongs to the bacterial ribosomal protein bL33 family K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000001353 104.0
TLS2_k127_26226_12 EamA-like transporter family - - - 0.00000000000000000000001132 113.0
TLS2_k127_26226_14 - - - - 0.000002557 51.0
TLS2_k127_26226_2 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004287 486.0
TLS2_k127_26226_3 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007717 404.0
TLS2_k127_26226_4 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 384.0
TLS2_k127_26226_5 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 334.0
TLS2_k127_26226_6 Bacterial transglutaminase-like N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 299.0
TLS2_k127_26226_7 EamA-like transporter family K08978 - - 0.00000000000000000000000000000000000000000000000000000000000000003396 226.0
TLS2_k127_26226_8 YbaK prolyl-tRNA synthetase K19055 - - 0.000000000000000000000000000000000000000000000000000000006991 208.0
TLS2_k127_26226_9 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 0.00000000000000000000000000000000000000004763 158.0
TLS2_k127_2695609_0 Putative transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 551.0
TLS2_k127_2695609_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 507.0
TLS2_k127_2695609_2 Phage integrase, N-terminal SAM-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004309 398.0
TLS2_k127_2807692_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1140.0
TLS2_k127_2807692_1 Belongs to the DEAD box helicase family K03732,K11927 - 3.6.4.13 1.782e-196 627.0
TLS2_k127_2807692_10 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000001674 245.0
TLS2_k127_2807692_11 peptidase - - - 0.0000000000000000000000000000000000000000001003 167.0
TLS2_k127_2807692_12 Conserved hypothetical protein (Lin0512_fam) - - - 0.000000000000000000000000000000000000000002826 157.0
TLS2_k127_2807692_13 Belongs to the bacterial histone-like protein family K03530 - - 0.0000000000000000000000000000000000009892 141.0
TLS2_k127_2807692_14 Protein of unknown function (DUF952) - - - 0.00000000000000000000000000000001038 132.0
TLS2_k127_2807692_15 - - - - 0.000000000000000001104 91.0
TLS2_k127_2807692_16 Recombinase zinc beta ribbon domain - - - 0.000885 46.0
TLS2_k127_2807692_2 Periplasmic binding protein K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 544.0
TLS2_k127_2807692_3 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 479.0
TLS2_k127_2807692_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 468.0
TLS2_k127_2807692_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 427.0
TLS2_k127_2807692_6 MatE K03327 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009241 400.0
TLS2_k127_2807692_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 355.0
TLS2_k127_2807692_8 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 338.0
TLS2_k127_2807692_9 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 318.0
TLS2_k127_2807894_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 5.449e-307 945.0
TLS2_k127_2807894_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 583.0
TLS2_k127_2807894_10 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000001003 198.0
TLS2_k127_2807894_11 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000001074 84.0
TLS2_k127_2807894_12 - - - - 0.0000003592 53.0
TLS2_k127_2807894_2 Malonyl-CoA decarboxylase K01578 - 4.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 574.0
TLS2_k127_2807894_3 Cytochrome c oxidase subunit III K02276 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 463.0
TLS2_k127_2807894_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007311 458.0
TLS2_k127_2807894_5 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007016 411.0
TLS2_k127_2807894_6 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 365.0
TLS2_k127_2807894_7 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 305.0
TLS2_k127_2807894_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002943 256.0
TLS2_k127_2807894_9 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004885 243.0
TLS2_k127_2813681_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.679e-302 937.0
TLS2_k127_2813681_1 FAD dependent oxidoreductase K07137 - - 1.815e-257 804.0
TLS2_k127_2813681_10 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009412 267.0
TLS2_k127_2813681_11 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000001101 234.0
TLS2_k127_2813681_12 Domain of unknown function (DUF1932) - - - 0.000000000000000000000000000000000000000000000000000000000000006966 227.0
TLS2_k127_2813681_13 Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000001466 222.0
TLS2_k127_2813681_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 537.0
TLS2_k127_2813681_3 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006394 538.0
TLS2_k127_2813681_4 COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 535.0
TLS2_k127_2813681_5 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 485.0
TLS2_k127_2813681_6 Belongs to the succinate malate CoA ligase beta subunit family K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 453.0
TLS2_k127_2813681_7 Aminotransferase K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009709 413.0
TLS2_k127_2813681_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 419.0
TLS2_k127_2813681_9 Belongs to the FPP GGPP synthase family K00795 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0090407,GO:1901576 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 314.0
TLS2_k127_2828097_0 TRAP transporter, 4TM 12TM fusion protein - - - 3.824e-232 737.0
TLS2_k127_2828097_1 PFAM extracellular solute-binding protein, family 5 K02035 - - 3.359e-204 649.0
TLS2_k127_2828097_10 Transposase - - - 0.0000000000000000000000000000000000005639 146.0
TLS2_k127_2828097_11 Epoxide hydrolase N terminus K01253,K21159 - 3.3.2.9 0.00000000000000000000000000000000005084 136.0
TLS2_k127_2828097_12 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus K06140 - - 0.000000000000000000000000000000000325 137.0
TLS2_k127_2828097_13 COG3666 Transposase and inactivated derivatives - - - 0.00000000000000000000000000004739 120.0
TLS2_k127_2828097_14 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000028 61.0
TLS2_k127_2828097_16 Transcription elongation factor K06140 - - 0.000000248 53.0
TLS2_k127_2828097_17 Histidine kinase - - - 0.0007961 44.0
TLS2_k127_2828097_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 578.0
TLS2_k127_2828097_3 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 445.0
TLS2_k127_2828097_4 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 438.0
TLS2_k127_2828097_5 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 406.0
TLS2_k127_2828097_6 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 378.0
TLS2_k127_2828097_7 TRAP transporter solute receptor TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 374.0
TLS2_k127_2828097_8 Dihydrodipicolinate synthetase family - - - 0.00000000000000000000000000000000000000000000000000000002239 211.0
TLS2_k127_2828097_9 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000293 157.0
TLS2_k127_2862590_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 1.771e-222 696.0
TLS2_k127_2862590_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 440.0
TLS2_k127_2862590_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 393.0
TLS2_k127_2870316_0 histidine kinase A domain protein K07647,K07678 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009837 413.0
TLS2_k127_2870316_1 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000000000000000000000000007576 243.0
TLS2_k127_2870316_2 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 0.000000000000000000002595 95.0
TLS2_k127_2870316_3 Histidine kinase K13246 - 3.1.4.52 0.0000000000002508 75.0
TLS2_k127_2870901_0 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 561.0
TLS2_k127_2870901_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 387.0
TLS2_k127_2870901_2 SmpA / OmlA family - - - 0.0000000000000000000000000000000000002029 148.0
TLS2_k127_2870901_3 Ubiquinol-cytochrome C chaperone K17662 - - 0.0000000000000000000005461 102.0
TLS2_k127_2880342_0 Diguanylate cyclase - - - 1.262e-287 898.0
TLS2_k127_2880342_1 Periplasmic binding protein - - - 3.356e-220 709.0
TLS2_k127_2880342_10 Protein of unknown function (DUF3829) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 426.0
TLS2_k127_2880342_11 COG0411 ABC-type branched-chain amino acid transport systems ATPase component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 370.0
TLS2_k127_2880342_12 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 372.0
TLS2_k127_2880342_13 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007527 336.0
TLS2_k127_2880342_14 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 317.0
TLS2_k127_2880342_15 Helix-turn-helix domain, rpiR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 298.0
TLS2_k127_2880342_16 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 308.0
TLS2_k127_2880342_17 Polysaccharide deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000001782 258.0
TLS2_k127_2880342_18 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000519 228.0
TLS2_k127_2880342_19 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000001829 153.0
TLS2_k127_2880342_2 Periplasmic binding protein K01999 - - 1.026e-217 683.0
TLS2_k127_2880342_20 Cytochrome P460 - - - 0.000000000000000000000003068 113.0
TLS2_k127_2880342_21 COG2863 Cytochrome c553 - - - 0.00000000000000001999 93.0
TLS2_k127_2880342_22 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K18299,K18902 - - 0.00000000000002253 74.0
TLS2_k127_2880342_23 - - - - 0.00000007626 59.0
TLS2_k127_2880342_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.935e-209 659.0
TLS2_k127_2880342_4 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 1.243e-208 654.0
TLS2_k127_2880342_5 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 3.435e-200 635.0
TLS2_k127_2880342_6 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006469 596.0
TLS2_k127_2880342_7 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006258 546.0
TLS2_k127_2880342_8 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 495.0
TLS2_k127_2880342_9 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 479.0
TLS2_k127_2880358_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 1.875e-266 827.0
TLS2_k127_2880358_1 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000556 379.0
TLS2_k127_2880358_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000001216 218.0
TLS2_k127_2880358_3 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.0000000000000000000789 94.0
TLS2_k127_2883505_0 aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 606.0
TLS2_k127_2883505_1 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 490.0
TLS2_k127_2883505_2 Protein containing von Willebrand factor type A (VWA) domain K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008277 458.0
TLS2_k127_2883505_3 metal-dependent hydrolase of the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 394.0
TLS2_k127_2883505_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 333.0
TLS2_k127_2883505_5 aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 313.0
TLS2_k127_2885559_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 8.439e-209 663.0
TLS2_k127_2885559_1 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 582.0
TLS2_k127_2885559_10 Protein-glutamate methylesterase K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000001004 287.0
TLS2_k127_2885559_11 50S ribosome-binding GTPase K06946 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004091 269.0
TLS2_k127_2885559_12 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000006862 275.0
TLS2_k127_2885559_13 - K01992 - - 0.00000000000000000000000000000000000000000000000000000000003451 233.0
TLS2_k127_2885559_14 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000008172 209.0
TLS2_k127_2885559_15 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000007137 192.0
TLS2_k127_2885559_16 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000005302 170.0
TLS2_k127_2885559_17 phosphorelay sensor kinase activity K03407,K10909,K12132 - 2.7.11.1,2.7.13.3 0.0000000000000000000000000000000004352 151.0
TLS2_k127_2885559_18 Asp/Glu/Hydantoin racemase K16841 - 5.1.99.3 0.000000000000000000000000000000005442 147.0
TLS2_k127_2885559_2 Peptidase dimerisation domain K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 537.0
TLS2_k127_2885559_20 UPF0391 membrane protein - - - 0.0000000000000000000003519 96.0
TLS2_k127_2885559_3 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 431.0
TLS2_k127_2885559_4 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 416.0
TLS2_k127_2885559_5 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 366.0
TLS2_k127_2885559_6 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 341.0
TLS2_k127_2885559_7 PFAM molybdopterin oxidoreductase Fe4S4 region K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 331.0
TLS2_k127_2885559_8 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 309.0
TLS2_k127_2885559_9 Peptidase C14 caspase catalytic subunit p20 K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 321.0
TLS2_k127_2886708_0 NADH-quinone oxidoreductase chain L K00341 - 1.6.5.3 0.0 1024.0
TLS2_k127_2886708_1 NADH-quinone oxidoreductase chain K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 3.669e-255 797.0
TLS2_k127_2886708_10 two component sensor kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002974 282.0
TLS2_k127_2886708_11 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005085 267.0
TLS2_k127_2886708_12 Belongs to the complex I subunit 6 family K00339 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000533 246.0
TLS2_k127_2886708_13 - - - - 0.000000000000000000000000000000000000000000000000000000000001239 215.0
TLS2_k127_2886708_14 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000001974 194.0
TLS2_k127_2886708_15 Fe-S metabolism associated domain K02426 - - 0.00000000000000000000000000000000000000000000000001879 187.0
TLS2_k127_2886708_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000005143 167.0
TLS2_k127_2886708_17 Cysteine-rich secretory protein family - - - 0.00000000000000000000000000000000000000001383 158.0
TLS2_k127_2886708_18 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000004305 139.0
TLS2_k127_2886708_19 Response regulator receiver domain - - - 0.000000000000000000000004642 114.0
TLS2_k127_2886708_2 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 1.013e-231 729.0
TLS2_k127_2886708_20 Glyoxalase - - - 0.00000000000000000000001347 104.0
TLS2_k127_2886708_21 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K03941 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3,1.6.99.3 0.0000000004846 59.0
TLS2_k127_2886708_22 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000005419 54.0
TLS2_k127_2886708_23 COG1951 Tartrate dehydratase alpha subunit Fumarate hydratase class I, N-terminal domain K01677,K03779 - 4.2.1.2,4.2.1.32 0.0002839 44.0
TLS2_k127_2886708_3 Acyl-CoA dehydrogenase, C-terminal domain K09456 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 604.0
TLS2_k127_2886708_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 584.0
TLS2_k127_2886708_5 aromatic amino acid beta-eliminating lyase threonine aldolase K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 473.0
TLS2_k127_2886708_6 HMGL-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 428.0
TLS2_k127_2886708_7 AAA ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 398.0
TLS2_k127_2886708_8 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008529 327.0
TLS2_k127_2886708_9 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 296.0
TLS2_k127_289039_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006141 543.0
TLS2_k127_289039_1 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003039 253.0
TLS2_k127_289039_2 N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000008776 215.0
TLS2_k127_289039_3 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000001599 191.0
TLS2_k127_289039_4 Acetyltransferase (GNAT) family - - - 0.000000000000003705 79.0
TLS2_k127_289039_5 2-hydroxychromene-2-carboxylate isomerase - - - 0.00000007717 57.0
TLS2_k127_289039_6 Sodium/calcium exchanger protein K07301 - - 0.00000007741 57.0
TLS2_k127_2899563_0 Domain of unknown function (DUF4159) - - - 0.0 1141.0
TLS2_k127_2899563_1 membrane - - - 2.457e-308 959.0
TLS2_k127_2899563_10 regulator of competence-specific genes K07343 - - 0.000000000000000000000000005552 115.0
TLS2_k127_2899563_2 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 8.084e-260 812.0
TLS2_k127_2899563_3 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008213 561.0
TLS2_k127_2899563_4 ATPase AAA K03924 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 547.0
TLS2_k127_2899563_5 TIGRFAM amidase, hydantoinase carbamoylase family K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 537.0
TLS2_k127_2899563_6 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 402.0
TLS2_k127_2899563_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 313.0
TLS2_k127_2899563_8 protein conserved in bacteria K09986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003347 245.0
TLS2_k127_2899563_9 KR domain - - - 0.000000000000000000000000000000000000000000000000000001613 193.0
TLS2_k127_2900029_0 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 1.069e-236 736.0
TLS2_k127_2900029_1 Belongs to the beta-ketoacyl-ACP synthases family K00647 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 3.909e-217 689.0
TLS2_k127_2900029_2 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 8.393e-196 617.0
TLS2_k127_2900029_3 Enoyl- acyl-carrier-protein reductase NADH K00208 GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 434.0
TLS2_k127_2900029_4 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006973 305.0
TLS2_k127_2900029_6 PFAM regulatory protein LysR - - - 0.0000000000000000000000000000000000000000000000000002482 196.0
TLS2_k127_2900029_7 - - - - 0.00000000000000000000000000000005072 137.0
TLS2_k127_2900029_8 MarR family - - - 0.0000000000000000000000000001138 124.0
TLS2_k127_2902665_0 TRAP dicarboxylate transporter, DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 531.0
TLS2_k127_2902665_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 447.0
TLS2_k127_2902665_2 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 422.0
TLS2_k127_2902665_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006087 421.0
TLS2_k127_2902665_4 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 367.0
TLS2_k127_2902665_5 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000001483 243.0
TLS2_k127_2902665_6 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000004584 173.0
TLS2_k127_2902665_7 Alpha/beta hydrolase family - - - 0.0000000000005159 70.0
TLS2_k127_2915377_0 Pyridoxal-phosphate dependent enzyme K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 529.0
TLS2_k127_2915377_1 mandelate racemase muconate lactonizing K20023 - 4.2.1.156,4.2.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008046 404.0
TLS2_k127_2915377_2 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 376.0
TLS2_k127_2915377_3 Short-chain dehydrogenase reductase SDR - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 315.0
TLS2_k127_2915377_4 Threonyl and Alanyl tRNA synthetase second additional domain K07050 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 308.0
TLS2_k127_2915377_5 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001659 288.0
TLS2_k127_2915377_6 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001742 289.0
TLS2_k127_2915377_7 Putative ATP-dependant zinc protease K05844 - - 0.0000000000000000009571 94.0
TLS2_k127_293342_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1228.0
TLS2_k127_293342_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.098e-273 857.0
TLS2_k127_293342_10 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008275 564.0
TLS2_k127_293342_11 Putative sugar-binding N-terminal domain K21948 - 2.7.1.217 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 510.0
TLS2_k127_293342_12 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000751 494.0
TLS2_k127_293342_13 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 495.0
TLS2_k127_293342_14 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 471.0
TLS2_k127_293342_15 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 468.0
TLS2_k127_293342_16 ABC transporter permease K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008845 474.0
TLS2_k127_293342_17 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 428.0
TLS2_k127_293342_18 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000559 415.0
TLS2_k127_293342_19 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 396.0
TLS2_k127_293342_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 3.553e-271 854.0
TLS2_k127_293342_20 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768,K01769 - 4.6.1.1,4.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 390.0
TLS2_k127_293342_21 Enoyl-(Acyl carrier protein) reductase K21883 - 1.1.1.401 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 376.0
TLS2_k127_293342_22 Alpha beta hydrolase K03928 - 3.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 351.0
TLS2_k127_293342_23 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 343.0
TLS2_k127_293342_24 TIGRFAM 3-hydroxybutyrate dehydrogenase K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 329.0
TLS2_k127_293342_25 belongs to the carbohydrate kinase PfkB family K18478 - 2.7.1.184 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008964 319.0
TLS2_k127_293342_26 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 313.0
TLS2_k127_293342_27 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 306.0
TLS2_k127_293342_28 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 300.0
TLS2_k127_293342_29 Transposase and inactivated K07494 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009857 291.0
TLS2_k127_293342_3 ABC-type dipeptide transport system periplasmic component K02035 - - 6.077e-228 719.0
TLS2_k127_293342_30 cyclic nucleotide-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000272 250.0
TLS2_k127_293342_31 ABC 3 transport family K09816 GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.0000000000000000000000000000000000000000000000000000000000000000000004665 258.0
TLS2_k127_293342_32 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000162 247.0
TLS2_k127_293342_33 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000000004844 235.0
TLS2_k127_293342_34 Protein of unknown function (DUF1036) - - - 0.00000000000000000000000000000000000000000000000000000000000001488 218.0
TLS2_k127_293342_35 protein affecting Mg2 Co2 transport K06195 - - 0.00000000000000000000000000000000000000000000000000000002982 200.0
TLS2_k127_293342_36 Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000155 199.0
TLS2_k127_293342_37 Hint domain - - - 0.0000000000000000000000000000000000000000006674 166.0
TLS2_k127_293342_38 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000003699 159.0
TLS2_k127_293342_39 FecR protein - - - 0.00000000000000000000000000000000000001421 154.0
TLS2_k127_293342_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.823e-212 672.0
TLS2_k127_293342_40 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000000000000000000000006934 141.0
TLS2_k127_293342_41 Lipolytic acyl hydrolase (LAH) - - - 0.00000000000000000000000002347 123.0
TLS2_k127_293342_42 - - - - 0.00000000000000000000000004138 111.0
TLS2_k127_293342_43 'Paired box' domain K07499 - - 0.000000000000000000000008128 105.0
TLS2_k127_293342_44 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0000000000000000004125 98.0
TLS2_k127_293342_46 Xylose isomerase-like TIM barrel - - - 0.0000000000000001758 90.0
TLS2_k127_293342_48 Conserved domain protein - - - 0.0007783 46.0
TLS2_k127_293342_5 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 3.556e-209 659.0
TLS2_k127_293342_6 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 3.436e-208 662.0
TLS2_k127_293342_7 acyl-CoA transferases carnitine dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008822 589.0
TLS2_k127_293342_8 Cyclic nucleotide-monophosphate binding domain K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 591.0
TLS2_k127_293342_9 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 577.0
TLS2_k127_2937851_0 Fumarate hydratase (Fumerase) K01677,K03779 - 4.2.1.2,4.2.1.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 576.0
TLS2_k127_2937851_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 565.0
TLS2_k127_2937851_10 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000000003545 99.0
TLS2_k127_2937851_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 455.0
TLS2_k127_2937851_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 385.0
TLS2_k127_2937851_4 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 303.0
TLS2_k127_2937851_5 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 310.0
TLS2_k127_2937851_6 HlyD membrane-fusion protein of T1SS K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006562 276.0
TLS2_k127_2937851_7 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008656 246.0
TLS2_k127_2937851_8 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.000000000000000000000000000000001001 137.0
TLS2_k127_2937851_9 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000000000003176 141.0
TLS2_k127_2942248_0 acyl-CoA dehydrogenase K00248,K00249,K20035 - 1.3.8.1,1.3.8.7 5.958e-253 793.0
TLS2_k127_2942248_1 SMART von Willebrand factor type A K09883 - 6.6.1.2 4.938e-223 707.0
TLS2_k127_2942248_10 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001782 273.0
TLS2_k127_2942248_11 heat shock protein DnaJ - - - 0.0000000000000000000000000000000000000000000000000000000000000000002325 236.0
TLS2_k127_2942248_12 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000004007 220.0
TLS2_k127_2942248_13 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000001319 200.0
TLS2_k127_2942248_14 Belongs to the BolA IbaG family K05527,K22066 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - 0.0000000000000000000000000000000000000006862 150.0
TLS2_k127_2942248_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.562e-216 675.0
TLS2_k127_2942248_3 Cobaltochelatase CobS subunit N terminal K09882 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 602.0
TLS2_k127_2942248_4 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009628 538.0
TLS2_k127_2942248_5 Putative serine dehydratase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 511.0
TLS2_k127_2942248_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 377.0
TLS2_k127_2942248_7 PFAM Bacterial regulatory proteins, crp family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 350.0
TLS2_k127_2942248_8 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 346.0
TLS2_k127_2942248_9 PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 287.0
TLS2_k127_2977974_0 GMC oxidoreductase K16873 - 1.1.3.47 1.473e-267 833.0
TLS2_k127_2977974_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 3.892e-245 771.0
TLS2_k127_2977974_10 Ferric uptake regulator family K09823 - - 0.0000000000000000000000000000000000000002755 155.0
TLS2_k127_2977974_2 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 4.856e-206 652.0
TLS2_k127_2977974_3 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 457.0
TLS2_k127_2977974_4 Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 369.0
TLS2_k127_2977974_5 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 294.0
TLS2_k127_2977974_6 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009428 302.0
TLS2_k127_2977974_7 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004937 290.0
TLS2_k127_2977974_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001309 251.0
TLS2_k127_2977974_9 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000007054 219.0
TLS2_k127_3014683_0 Heat shock 70 kDa protein K04043 - - 5.777e-310 960.0
TLS2_k127_3014683_1 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 3.301e-198 625.0
TLS2_k127_3014683_10 Protein of unknown function - - - 0.00000000000002372 81.0
TLS2_k127_3014683_11 PFAM PRC-barrel domain protein - - - 0.000000003286 67.0
TLS2_k127_3014683_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007979 543.0
TLS2_k127_3014683_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 527.0
TLS2_k127_3014683_4 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 506.0
TLS2_k127_3014683_5 ErfK YbiS YcfS YnhG family protein K21470,K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 495.0
TLS2_k127_3014683_6 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009447 248.0
TLS2_k127_3014683_7 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000002524 213.0
TLS2_k127_3014683_8 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000000000005557 193.0
TLS2_k127_3014683_9 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000008353 182.0
TLS2_k127_3032271_0 PHB de-polymerase C-terminus K05973 - 3.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 595.0
TLS2_k127_3032271_1 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 521.0
TLS2_k127_3032271_2 dehydrogenase K00218 - 1.3.1.33 0.0000000000000000000000000000000000004443 154.0
TLS2_k127_3032271_3 PFAM DoxX family protein K15977 - - 0.0000000000000000000000000000004831 124.0
TLS2_k127_3032271_4 methylamine metabolic process K15977 - - 0.000003978 51.0
TLS2_k127_3032271_5 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.00006681 45.0
TLS2_k127_3094472_0 Bacterial extracellular solute-binding protein K02027 - - 1.183e-216 685.0
TLS2_k127_3094472_1 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 585.0
TLS2_k127_3094472_2 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 522.0
TLS2_k127_3094472_3 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 486.0
TLS2_k127_313635_0 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 371.0
TLS2_k127_313635_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 349.0
TLS2_k127_313635_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000009731 187.0
TLS2_k127_313635_3 Haem-degrading - - - 0.00000000000000000000000000000000000000000000003227 178.0
TLS2_k127_313635_4 Transposase K07481 - - 0.00000000000000000000000000000001035 129.0
TLS2_k127_313635_5 - - - - 0.0000000002756 63.0
TLS2_k127_3173006_0 oligoendopeptidase K08602 - - 1.586e-288 898.0
TLS2_k127_3173006_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 519.0
TLS2_k127_3173006_10 Competence-damaged protein K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000006346 200.0
TLS2_k127_3173006_11 oligoketide cyclase lipid transport protein K18588 - - 0.0000000000000000000000000000000000000000000008615 178.0
TLS2_k127_3173006_12 Major Facilitator Superfamily K07552 - - 0.000000000000000000000000000000000000000000003396 183.0
TLS2_k127_3173006_13 ATP-independent chaperone mediated protein folding - - - 0.0000000000000000000000000000000000000000001125 167.0
TLS2_k127_3173006_14 Transglycosylase associated protein - - - 0.00000000000000006615 83.0
TLS2_k127_3173006_15 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00003926 48.0
TLS2_k127_3173006_2 PFAM Rhodanese domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 525.0
TLS2_k127_3173006_3 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 509.0
TLS2_k127_3173006_4 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 512.0
TLS2_k127_3173006_5 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 443.0
TLS2_k127_3173006_6 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009275 399.0
TLS2_k127_3173006_7 Belongs to the DapA family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007726 355.0
TLS2_k127_3173006_8 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 340.0
TLS2_k127_3173006_9 GMC oxidoreductase K20927,K21166 - 1.1.1.400 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 317.0
TLS2_k127_3183434_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1129.0
TLS2_k127_3183434_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 1.642e-285 896.0
TLS2_k127_3183434_10 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000004712 136.0
TLS2_k127_3183434_11 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000004248 122.0
TLS2_k127_3183434_12 TonB dependent receptor K02014 - - 0.000000002268 61.0
TLS2_k127_3183434_2 Amidohydrolase family K01465 - 3.5.2.3 1.795e-205 662.0
TLS2_k127_3183434_3 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 515.0
TLS2_k127_3183434_4 DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 431.0
TLS2_k127_3183434_5 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000009369 214.0
TLS2_k127_3183434_6 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000002073 219.0
TLS2_k127_3183434_7 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000005403 220.0
TLS2_k127_3183434_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000004594 184.0
TLS2_k127_3183434_9 Protein of unknown function (DUF983) - - - 0.000000000000000000000000000000000000000000000001827 180.0
TLS2_k127_3208440_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 1.778e-232 725.0
TLS2_k127_3208440_1 FAD linked oxidases, C-terminal domain K00104 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.3.15 5.266e-227 713.0
TLS2_k127_3208440_10 Peptidase membrane zinc metallopeptidase K06973 - - 0.0000000000000000000000000000000000000000000000001805 182.0
TLS2_k127_3208440_11 PFAM cytochrome c class I K08738 - - 0.000000000000000000000000000000000000405 145.0
TLS2_k127_3208440_2 Cysteine-rich domain K11473 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - 1.86e-204 644.0
TLS2_k127_3208440_3 Belongs to the CinA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 593.0
TLS2_k127_3208440_4 FAD linked oxidase K11472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 434.0
TLS2_k127_3208440_5 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 363.0
TLS2_k127_3208440_6 D-isomer specific 2-hydroxyacid dehydrogenase K00018 - 1.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008364 355.0
TLS2_k127_3208440_7 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007236 283.0
TLS2_k127_3208440_8 Lysin motif K06194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008834 288.0
TLS2_k127_3208440_9 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000008046 212.0
TLS2_k127_3271310_0 B12 binding domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1337.0
TLS2_k127_3271310_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007572 351.0
TLS2_k127_3271310_2 Ribosomal protein L11 methyltransferase (PrmA) - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003822 264.0
TLS2_k127_3271310_3 - - - - 0.000000000000000000000000000000001054 142.0
TLS2_k127_3271310_4 PFAM Usg family protein - - - 0.00000000000000000000000000000009151 127.0
TLS2_k127_3271310_5 Protein of unknown function (DUF1761) - - - 0.00000000000000000000000000003243 122.0
TLS2_k127_3271310_6 protein dimerization activity K03746 - - 0.000000000000000000000000001153 118.0
TLS2_k127_3271310_7 glutamate-ammonia ligase activity - - - 0.000000000000000000000001782 113.0
TLS2_k127_3280198_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 1.385e-310 976.0
TLS2_k127_3280198_1 COG1042 Acyl-CoA synthetase (NDP forming) - - - 7.438e-199 645.0
TLS2_k127_3280198_10 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000000000000000000000000000001934 217.0
TLS2_k127_3280198_11 YGGT family K02221 - - 0.0000000000000000000000000000000000005975 141.0
TLS2_k127_3280198_12 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.000000000000000000000000000009913 122.0
TLS2_k127_3280198_13 2'-5' RNA ligase superfamily - - - 0.00000000000000000000001513 106.0
TLS2_k127_3280198_14 Belongs to the UPF0235 family K09131 - - 0.000000000000000003994 92.0
TLS2_k127_3280198_15 transduction histidine kinase - - - 0.00000000000000898 86.0
TLS2_k127_3280198_2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 448.0
TLS2_k127_3280198_3 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009395 434.0
TLS2_k127_3280198_4 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 406.0
TLS2_k127_3280198_5 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 370.0
TLS2_k127_3280198_6 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009187 357.0
TLS2_k127_3280198_7 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004417 317.0
TLS2_k127_3280198_8 Protein conserved in bacteria K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003484 286.0
TLS2_k127_3280198_9 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000005613 225.0
TLS2_k127_328255_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 4.502e-224 704.0
TLS2_k127_328255_1 ABC-type uncharacterized transport system K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 566.0
TLS2_k127_328255_2 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006027 421.0
TLS2_k127_328255_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 359.0
TLS2_k127_328255_4 SNARE associated golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000004623 215.0
TLS2_k127_328255_5 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000005616 209.0
TLS2_k127_328255_6 GcrA cell cycle regulator K13583 - - 0.0000000000000000000000000000000000000000000000000000000001362 212.0
TLS2_k127_3293715_0 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 3.234e-214 676.0
TLS2_k127_3293715_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 534.0
TLS2_k127_3293715_10 Protein of unknown function (DUF2793) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000646 281.0
TLS2_k127_3293715_11 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000381 241.0
TLS2_k127_3293715_12 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000001824 222.0
TLS2_k127_3293715_13 PFAM Adenylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000002829 168.0
TLS2_k127_3293715_14 - - - - 0.000000000000000000000000000002113 132.0
TLS2_k127_3293715_15 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000001839 122.0
TLS2_k127_3293715_16 Fibronectin type III domain - - - 0.00000000000000000000009229 113.0
TLS2_k127_3293715_17 - - - - 0.000000000000000374 93.0
TLS2_k127_3293715_18 - - - - 0.0000000000000004944 92.0
TLS2_k127_3293715_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 524.0
TLS2_k127_3293715_3 Belongs to the AB hydrolase superfamily. MetX family K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 494.0
TLS2_k127_3293715_4 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 478.0
TLS2_k127_3293715_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 467.0
TLS2_k127_3293715_6 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 435.0
TLS2_k127_3293715_7 LysR family K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 391.0
TLS2_k127_3293715_8 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 372.0
TLS2_k127_3293715_9 Histone methylation protein DOT1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 325.0
TLS2_k127_3331013_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1208.0
TLS2_k127_3331013_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038,K21977 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000841 542.0
TLS2_k127_3331013_2 Sulfatase K03760 - 2.7.8.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 488.0
TLS2_k127_3331013_3 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 411.0
TLS2_k127_3331013_4 Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate K01003 - 4.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007312 386.0
TLS2_k127_3331013_5 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000000000003347 201.0
TLS2_k127_3331013_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000003027 170.0
TLS2_k127_3331013_7 phosphohistidine phosphatase, SixA K08296 - - 0.000000000000000000000000000000000000000002632 161.0
TLS2_k127_333108_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 2.022e-212 665.0
TLS2_k127_333108_1 Protein of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 612.0
TLS2_k127_333108_10 Predicted integral membrane protein (DUF2282) - - - 0.000000000000000000000000000004142 132.0
TLS2_k127_333108_2 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 439.0
TLS2_k127_333108_3 Belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 386.0
TLS2_k127_333108_4 Putative DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009501 267.0
TLS2_k127_333108_5 Protein of unknown function (DUF1109) - - - 0.000000000000000000000000000000000000000000000000000000000000000001211 237.0
TLS2_k127_333108_6 DoxX K15977 - - 0.000000000000000000000000000000000000000000000000000000007593 205.0
TLS2_k127_333108_7 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000003827 179.0
TLS2_k127_333108_8 Mo-co oxidoreductase dimerisation domain K00387 - 1.8.3.1 0.00000000000000000000000000000000000006441 143.0
TLS2_k127_333108_9 cytochrome - - - 0.0000000000000000000000000000004192 127.0
TLS2_k127_33385_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 4.2e-229 721.0
TLS2_k127_33385_1 Cobalamin-independent synthase, Catalytic domain K00549,K22363 - 2.1.1.14,4.4.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000416 530.0
TLS2_k127_33385_2 Domain of unknown function (DUF2437) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002576 372.0
TLS2_k127_33385_3 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009212 379.0
TLS2_k127_33385_4 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 289.0
TLS2_k127_33385_5 glycine betaine transport system, permease K02001 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0008150,GO:0015695,GO:0015696,GO:0015871,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0005072 51.0
TLS2_k127_3342586_0 Belongs to the peptidase S16 family - - - 1.954e-306 962.0
TLS2_k127_3342586_1 Elongation factor G, domain IV K02355 - - 9.781e-299 934.0
TLS2_k127_3342586_10 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 359.0
TLS2_k127_3342586_11 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006025 350.0
TLS2_k127_3342586_12 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 341.0
TLS2_k127_3342586_13 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K08319 - 1.1.1.411 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 331.0
TLS2_k127_3342586_14 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002816 272.0
TLS2_k127_3342586_15 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007447 278.0
TLS2_k127_3342586_16 PFAM ABC transporter related K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001882 258.0
TLS2_k127_3342586_17 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000007666 259.0
TLS2_k127_3342586_18 Belongs to the TPP enzyme family K01637 - 4.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000001146 255.0
TLS2_k127_3342586_19 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001943 248.0
TLS2_k127_3342586_2 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 561.0
TLS2_k127_3342586_20 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000003826 209.0
TLS2_k127_3342586_21 CHAD - - - 0.000000000000000000000000000000000000002013 159.0
TLS2_k127_3342586_22 - - - - 0.000000000000000000003628 104.0
TLS2_k127_3342586_23 COG2104 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.00000000000008934 78.0
TLS2_k127_3342586_24 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000004606 71.0
TLS2_k127_3342586_25 - - - - 0.0007497 46.0
TLS2_k127_3342586_3 PFAM fumarate lyase K01756,K01857 - 4.3.2.2,5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 559.0
TLS2_k127_3342586_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 445.0
TLS2_k127_3342586_5 AFG1-like ATPase K06916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004426 440.0
TLS2_k127_3342586_6 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 415.0
TLS2_k127_3342586_7 Polyphosphate kinase 2 (PPK2) K22468 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0042802,GO:0044237 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 391.0
TLS2_k127_3342586_8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007582 376.0
TLS2_k127_3342586_9 branched-chain amino acid K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009501 372.0
TLS2_k127_3351272_0 poly(R)-hydroxyalkanoic acid synthase K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.363e-277 864.0
TLS2_k127_3351272_1 exonuclease RecJ K07462 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - 1.137e-251 794.0
TLS2_k127_3351272_10 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008196 471.0
TLS2_k127_3351272_11 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 452.0
TLS2_k127_3351272_12 AAA domain, putative AbiEii toxin, Type IV TA system K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 446.0
TLS2_k127_3351272_13 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005377 422.0
TLS2_k127_3351272_14 Transport permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 418.0
TLS2_k127_3351272_15 Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system K10831 - 3.6.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 408.0
TLS2_k127_3351272_16 Ethanolamine utilisation - propanediol utilisation K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 402.0
TLS2_k127_3351272_17 COG4521 ABC-type taurine transport system periplasmic component K15551 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 385.0
TLS2_k127_3351272_18 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 373.0
TLS2_k127_3351272_19 ABC-type nitrate sulfonate bicarbonate transport system permease component K15552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 375.0
TLS2_k127_3351272_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 4.971e-243 760.0
TLS2_k127_3351272_20 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 367.0
TLS2_k127_3351272_21 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 355.0
TLS2_k127_3351272_22 Sel1-like repeats. K07126,K13582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 347.0
TLS2_k127_3351272_23 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005013 273.0
TLS2_k127_3351272_24 Putative transmembrane protein (Alph_Pro_TM) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000847 264.0
TLS2_k127_3351272_25 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000002344 240.0
TLS2_k127_3351272_26 PFAM Sporulation domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000009328 239.0
TLS2_k127_3351272_27 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000001528 224.0
TLS2_k127_3351272_28 - - - - 0.00000000000000000000000000000000000000000000000000000000001739 218.0
TLS2_k127_3351272_29 redox protein regulator of disulfide bond formation - - - 0.000000000000000000000000000000000000000000000000000000001684 205.0
TLS2_k127_3351272_3 Aldehyde dehydrogenase family K00135 GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009266,GO:0009314,GO:0009408,GO:0009416,GO:0009448,GO:0009450,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009628,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0031974,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050896,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072329,GO:0072593,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.16,1.2.1.20,1.2.1.79 4.017e-221 696.0
TLS2_k127_3351272_30 NIPSNAP - - - 0.00000000000000000000000000000000000000000000000000000005167 197.0
TLS2_k127_3351272_31 enzyme involved in biosynthesis of extracellular polysaccharides - - - 0.00000000000000000000000000000000000000000000000003472 183.0
TLS2_k127_3351272_32 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000009034 169.0
TLS2_k127_3351272_33 Bacterial SH3 domain homologues - - - 0.0000000000000000000000000000000000001201 153.0
TLS2_k127_3351272_34 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000008873 139.0
TLS2_k127_3351272_35 - - - - 0.00000000000000000000001303 102.0
TLS2_k127_3351272_37 Low affinity iron permease - - - 0.0000000000000000001688 93.0
TLS2_k127_3351272_38 Evidence 5 No homology to any previously reported sequences - - - 0.0000000004555 64.0
TLS2_k127_3351272_39 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.000000003617 63.0
TLS2_k127_3351272_4 PFAM Aminotransferase class I and II K14261 GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 5.058e-214 671.0
TLS2_k127_3351272_5 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 7.124e-211 666.0
TLS2_k127_3351272_6 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 613.0
TLS2_k127_3351272_7 Glycine cleavage T-protein C-terminal barrel domain K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 503.0
TLS2_k127_3351272_8 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005089 488.0
TLS2_k127_3351272_9 Amino-transferase class IV K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 481.0
TLS2_k127_3370628_0 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 519.0
TLS2_k127_3370628_1 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 470.0
TLS2_k127_3370628_2 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006321 306.0
TLS2_k127_3370628_3 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000005213 254.0
TLS2_k127_3370628_4 Putative diguanylate phosphodiesterase K13593 - - 0.000000000000000000000000000000000000000000000000000000000001216 226.0
TLS2_k127_3370628_5 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000000000000000000008059 171.0
TLS2_k127_3370628_6 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000004887 161.0
TLS2_k127_3370628_7 - - - - 0.0000000000000000000000000000000000000004635 156.0
TLS2_k127_3370628_8 - - - - 0.0000000000000000000000000000000000001398 152.0
TLS2_k127_343554_0 phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.0 1059.0
TLS2_k127_343554_1 Luciferase-like monooxygenase - - - 3.319e-241 752.0
TLS2_k127_343554_2 NADH-ubiquinone oxidoreductase chain 49kDa - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003565 277.0
TLS2_k127_343554_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004304 266.0
TLS2_k127_343554_4 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003232 255.0
TLS2_k127_343554_5 adenylate kinase activity K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000227 170.0
TLS2_k127_343554_6 - - - - 0.0003443 44.0
TLS2_k127_3435655_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1406.0
TLS2_k127_3435655_1 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004513 564.0
TLS2_k127_3435655_2 PFAM transferase hexapeptide repeat containing protein K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006173 446.0
TLS2_k127_3435655_3 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000001347 202.0
TLS2_k127_3435655_4 - - - - 0.00000000000000000000000000000000000000156 156.0
TLS2_k127_3435655_5 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000005284 119.0
TLS2_k127_347889_0 Bacterial membrane protein, YfhO - - - 1.181e-228 735.0
TLS2_k127_347889_1 MgsA AAA+ ATPase C terminal K07478 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 3.724e-215 674.0
TLS2_k127_347889_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 499.0
TLS2_k127_347889_3 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 501.0
TLS2_k127_347889_4 Gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 483.0
TLS2_k127_347889_5 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005422 257.0
TLS2_k127_347889_6 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003793 252.0
TLS2_k127_347889_7 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000000000000000000005774 109.0
TLS2_k127_347889_8 CoA-transferase family III - - - 0.0000000007156 62.0
TLS2_k127_3480693_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007467 586.0
TLS2_k127_3480693_1 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 473.0
TLS2_k127_3480693_10 Sel1-like repeats. K07126 - - 0.00000000001665 73.0
TLS2_k127_3480693_2 Transporter associated domain K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 356.0
TLS2_k127_3480693_3 Poly A polymerase head domain K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008935 348.0
TLS2_k127_3480693_4 Haloacid dehalogenase K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001651 268.0
TLS2_k127_3480693_5 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004979 229.0
TLS2_k127_3480693_6 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000000002062 160.0
TLS2_k127_3480693_7 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.00000000000000000000000000000003231 134.0
TLS2_k127_3480693_8 DNA polymerase K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.00000000000000003662 87.0
TLS2_k127_3480693_9 - - - - 0.000000000000001543 89.0
TLS2_k127_3487126_0 FAD dependent oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 577.0
TLS2_k127_3487126_1 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 575.0
TLS2_k127_3487126_2 4Fe-4S dicluster domain K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 389.0
TLS2_k127_3487126_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 340.0
TLS2_k127_3487126_4 Protein of unknown function (DUF3303) - - - 0.00000000000000000000000000000004367 141.0
TLS2_k127_3487126_5 Thiopurine S-methyltransferase (TPMT) - - - 0.000002298 56.0
TLS2_k127_3491674_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 572.0
TLS2_k127_3491674_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 538.0
TLS2_k127_3491674_2 YcjX-like family, DUF463 K06918 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 529.0
TLS2_k127_3491674_3 GMC oxidoreductase K00108 - 1.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 505.0
TLS2_k127_3491674_4 Domain of unknown function (DUF697) K08990 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 342.0
TLS2_k127_3491674_5 EamA-like transporter family K15270 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004189 262.0
TLS2_k127_3491674_6 EamA-like transporter family K15270 - - 0.0000000000000000000000000000000000000000000000000000000000000005994 231.0
TLS2_k127_3491674_7 Permeases of the drug metabolite transporter (DMT) superfamily K15270 - - 0.000000000000000000000000000000000000000000000000000000000000003798 228.0
TLS2_k127_3493372_0 VWA domain containing CoxE-like protein K09989 - - 6.593e-199 626.0
TLS2_k127_3493372_1 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 395.0
TLS2_k127_3493372_2 PFAM Integral membrane protein TerC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 356.0
TLS2_k127_3493372_3 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000198 250.0
TLS2_k127_3493372_4 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000005352 233.0
TLS2_k127_3493372_5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K01487,K11991 - 3.5.4.1,3.5.4.3,3.5.4.33 0.00000000000000000000000000000000000000000000000000000000005182 208.0
TLS2_k127_3493372_6 - - - - 0.0000000000000000000000000000000000000000005445 168.0
TLS2_k127_3493372_7 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000001969 132.0
TLS2_k127_3493372_8 DsrE/DsrF/DrsH-like family - - - 0.000000007295 58.0
TLS2_k127_3501585_0 FtsX-like permease family K02004 - - 1.633e-263 833.0
TLS2_k127_3501585_1 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 396.0
TLS2_k127_3501585_10 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000000006862 194.0
TLS2_k127_3501585_11 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000004253 177.0
TLS2_k127_3501585_12 - K09004 - - 0.0000000000000000000000000000000000000000000001547 176.0
TLS2_k127_3501585_13 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000001445 135.0
TLS2_k127_3501585_14 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000001479 125.0
TLS2_k127_3501585_2 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 317.0
TLS2_k127_3501585_3 L-lysine 6-monooxygenase (NADPH-requiring) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 325.0
TLS2_k127_3501585_4 Major Facilitator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 329.0
TLS2_k127_3501585_5 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 298.0
TLS2_k127_3501585_6 PFAM lipolytic protein G-D-S-L family K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000001778 252.0
TLS2_k127_3501585_7 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000002817 226.0
TLS2_k127_3501585_8 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.00000000000000000000000000000000000000000000000000000000000009821 214.0
TLS2_k127_3501585_9 Belongs to the HesB IscA family K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000002834 207.0
TLS2_k127_3526919_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0 1268.0
TLS2_k127_3526919_1 monooxygenase - - - 3.321e-201 635.0
TLS2_k127_3526919_10 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000003712 156.0
TLS2_k127_3526919_12 Bacterial dnaA protein helix-turn-helix domain - - - 0.0000000000000000000000001702 111.0
TLS2_k127_3526919_2 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 561.0
TLS2_k127_3526919_3 Acyl-CoA dehydrogenase, middle domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 382.0
TLS2_k127_3526919_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003127 363.0
TLS2_k127_3526919_5 Aldolase/RraA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008067 371.0
TLS2_k127_3526919_6 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005114 339.0
TLS2_k127_3526919_7 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K00557,K03215 - 2.1.1.190,2.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 347.0
TLS2_k127_3526919_8 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000007961 245.0
TLS2_k127_3526919_9 Flavin reductase like domain K09024,K13786 - 1.16.8.1 0.00000000000000000000000000000000000000000000001093 176.0
TLS2_k127_3534554_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0 1092.0
TLS2_k127_3534554_1 Belongs to the CarA family K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 7.184e-213 667.0
TLS2_k127_3534554_10 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000005356 189.0
TLS2_k127_3534554_11 DNA repair protein MmcB-like - - - 0.000000000000000000000000000000000000000000000000006658 186.0
TLS2_k127_3534554_12 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000001084 196.0
TLS2_k127_3534554_13 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000000000000000000000000000000000005656 166.0
TLS2_k127_3534554_14 succinate dehydrogenase K00241 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000002142 163.0
TLS2_k127_3534554_15 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000009569 135.0
TLS2_k127_3534554_16 OsmC-like protein - - - 0.000000000000000000000000000001516 126.0
TLS2_k127_3534554_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 7.245e-209 655.0
TLS2_k127_3534554_3 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101 - 1.1.2.3 8.739e-200 628.0
TLS2_k127_3534554_4 PHB de-polymerase C-terminus K05973 - 3.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 605.0
TLS2_k127_3534554_5 Histidine kinase K15011 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008471 464.0
TLS2_k127_3534554_6 response regulator K15012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 336.0
TLS2_k127_3534554_7 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003297 260.0
TLS2_k127_3534554_8 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000000002197 236.0
TLS2_k127_3534554_9 protein SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000159 224.0
TLS2_k127_3554569_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 545.0
TLS2_k127_3554569_1 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 441.0
TLS2_k127_3554569_2 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000006774 129.0
TLS2_k127_3554569_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000004062 82.0
TLS2_k127_3566317_0 formate dehydrogenase K00123 - 1.17.1.9 0.0 1701.0
TLS2_k127_3566317_1 Bacterial NAD-glutamate dehydrogenase K15371 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 0.0 1379.0
TLS2_k127_3566317_10 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000003313 214.0
TLS2_k127_3566317_11 NADH ubiquinone oxidoreductase 24 kD subunit K00127 - - 0.00000000000000000000000000000000000000000000000000000000009715 208.0
TLS2_k127_3566317_12 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.0000000000000000008694 91.0
TLS2_k127_3566317_13 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000000162 81.0
TLS2_k127_3566317_2 NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit K00124,K00335 - 1.6.5.3 8.26e-244 769.0
TLS2_k127_3566317_3 Domain of unknown function (DUF4131) K02238 - - 1.055e-197 640.0
TLS2_k127_3566317_4 Major facilitator superfamily K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 574.0
TLS2_k127_3566317_5 homoserine dehydrogenase K00003 GO:0003674,GO:0003824,GO:0004412,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004186 561.0
TLS2_k127_3566317_6 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 422.0
TLS2_k127_3566317_7 Protein of unknown function (DUF1013) K09987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008153 322.0
TLS2_k127_3566317_8 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 295.0
TLS2_k127_3566317_9 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000001638 228.0
TLS2_k127_3607398_0 Recombinase zinc beta ribbon domain - - - 1.699e-203 649.0
TLS2_k127_3607398_1 HpcH/HpaI aldolase/citrate lyase family K01630 - 4.1.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000001502 268.0
TLS2_k127_3607398_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001094 242.0
TLS2_k127_3607398_3 NAD binding K00015,K00058 - 1.1.1.26,1.1.1.399,1.1.1.95 0.000000000000000001584 89.0
TLS2_k127_3609957_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1064.0
TLS2_k127_3609957_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 371.0
TLS2_k127_3609957_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009339 359.0
TLS2_k127_3609957_3 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000005167 120.0
TLS2_k127_3714342_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 375.0
TLS2_k127_3714342_1 signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 378.0
TLS2_k127_3714342_2 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001444 278.0
TLS2_k127_3714342_3 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000008468 233.0
TLS2_k127_3714342_4 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.000000000000000000000000000000000000000000001096 166.0
TLS2_k127_3714342_6 Pfam:DUF1049 - - - 0.000000000000000000000000000000000000008764 148.0
TLS2_k127_3746632_0 Type II/IV secretion system protein K02283 - - 2.103e-264 820.0
TLS2_k127_3746632_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 6.994e-238 747.0
TLS2_k127_3746632_10 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 524.0
TLS2_k127_3746632_11 COG1042 Acyl-CoA synthetase (NDP forming) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 533.0
TLS2_k127_3746632_12 MlrC C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 517.0
TLS2_k127_3746632_13 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 496.0
TLS2_k127_3746632_14 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858,K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009539 496.0
TLS2_k127_3746632_15 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 475.0
TLS2_k127_3746632_16 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 453.0
TLS2_k127_3746632_17 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 422.0
TLS2_k127_3746632_18 Type II secretion system K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 414.0
TLS2_k127_3746632_19 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 424.0
TLS2_k127_3746632_2 ABC transporter transmembrane region 2 K02471 - - 7.641e-231 732.0
TLS2_k127_3746632_20 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000866 404.0
TLS2_k127_3746632_21 PFAM Na dependent nucleoside transporter K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008025 396.0
TLS2_k127_3746632_22 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 377.0
TLS2_k127_3746632_23 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 374.0
TLS2_k127_3746632_24 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 368.0
TLS2_k127_3746632_25 Type II secretion system (T2SS), protein F K12510 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 338.0
TLS2_k127_3746632_26 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 333.0
TLS2_k127_3746632_27 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 316.0
TLS2_k127_3746632_28 Domain of unknown function (DUF4394) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 305.0
TLS2_k127_3746632_29 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 297.0
TLS2_k127_3746632_3 Berberine and berberine like - - - 1.45e-227 718.0
TLS2_k127_3746632_30 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007271 273.0
TLS2_k127_3746632_31 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008299 252.0
TLS2_k127_3746632_32 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000002229 231.0
TLS2_k127_3746632_33 Transition state regulatory protein AbrB K07120 - - 0.00000000000000000000000000000000000000000000000000000000000000005197 236.0
TLS2_k127_3746632_34 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000006291 217.0
TLS2_k127_3746632_35 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000002552 211.0
TLS2_k127_3746632_36 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000002559 209.0
TLS2_k127_3746632_37 dehydratase K17865 GO:0003674,GO:0003824,GO:0003859,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0071704 4.2.1.55 0.000000000000000000000000000000000000000000000000000000004289 203.0
TLS2_k127_3746632_38 Phosphotransferase system mannose fructose-specific component IIA K02793 - 2.7.1.191 0.00000000000000000000000000000000000000000000000000000002599 199.0
TLS2_k127_3746632_39 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000101 200.0
TLS2_k127_3746632_4 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01738,K01740 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 6.676e-206 650.0
TLS2_k127_3746632_40 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000000000000004689 197.0
TLS2_k127_3746632_41 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000002044 201.0
TLS2_k127_3746632_42 Anti-sigma-K factor rskA - - - 0.000000000000000000000000000000000000000000000000000396 194.0
TLS2_k127_3746632_43 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000004116 188.0
TLS2_k127_3746632_44 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000004207 187.0
TLS2_k127_3746632_45 Zincin-like metallopeptidase K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000001081 173.0
TLS2_k127_3746632_46 PAS domain - - - 0.000000000000000000000000000000000000000000043 169.0
TLS2_k127_3746632_47 Response regulator receiver K03413 - - 0.0000000000000000000000000000000000000007998 155.0
TLS2_k127_3746632_48 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000464 137.0
TLS2_k127_3746632_49 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006808,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702 - 0.000000000000000000000000001378 114.0
TLS2_k127_3746632_5 acyl-CoA dehydrogenase K00249 - 1.3.8.7 1.438e-205 644.0
TLS2_k127_3746632_51 Uncharacterized protein conserved in bacteria (DUF2076) K09945 - - 0.0000000000000000014 95.0
TLS2_k127_3746632_6 AAA domain K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 569.0
TLS2_k127_3746632_7 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008582 572.0
TLS2_k127_3746632_8 PrkA AAA domain K07180 GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 561.0
TLS2_k127_3746632_9 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 536.0
TLS2_k127_3752545_0 Amidohydrolase family K01465 - 3.5.2.3 2.678e-198 630.0
TLS2_k127_3752545_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 580.0
TLS2_k127_3752545_10 Belongs to the WrbA family K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 337.0
TLS2_k127_3752545_11 ABC transporter, periplasmic molybdate-binding protein K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005223 280.0
TLS2_k127_3752545_12 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007088 282.0
TLS2_k127_3752545_13 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000005453 213.0
TLS2_k127_3752545_15 ModE family K02019 - - 0.000000000000000000000000000000000002865 142.0
TLS2_k127_3752545_16 PFAM Nitroreductase - - - 0.00000000000000000000000000000002472 133.0
TLS2_k127_3752545_17 Thioredoxin-like - - - 0.00000000000000000000000000001904 125.0
TLS2_k127_3752545_18 GCN5-related N-acetyl-transferase K06975 - - 0.00000000000000000000000000002989 121.0
TLS2_k127_3752545_19 TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD K02281 - - 0.0000000000000000000003406 109.0
TLS2_k127_3752545_2 Mur ligase middle domain K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 519.0
TLS2_k127_3752545_20 Belongs to the SEDS family K03588 - - 0.000000000000256 77.0
TLS2_k127_3752545_3 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008157 500.0
TLS2_k127_3752545_4 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004919 435.0
TLS2_k127_3752545_5 Belongs to the GSP D family K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 417.0
TLS2_k127_3752545_6 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 405.0
TLS2_k127_3752545_7 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005587 398.0
TLS2_k127_3752545_8 Pirin K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 353.0
TLS2_k127_3752545_9 Binding-protein-dependent transport system inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009882 349.0
TLS2_k127_3755258_0 Glutamate synthase K00265 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 0.0 2185.0
TLS2_k127_3761802_0 Belongs to the GARS family K01945 - 6.3.4.13 2.93e-205 646.0
TLS2_k127_3761802_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 2.553e-198 632.0
TLS2_k127_3761802_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005549 315.0
TLS2_k127_3761802_11 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 298.0
TLS2_k127_3761802_12 Alpha beta hydrolase K01561 - 3.8.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 299.0
TLS2_k127_3761802_13 Putative ATP-dependant zinc protease K05844 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001532 287.0
TLS2_k127_3761802_14 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01450,K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000002085 239.0
TLS2_k127_3761802_15 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000002882 220.0
TLS2_k127_3761802_16 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000002486 215.0
TLS2_k127_3761802_17 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone K03880 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000001652 200.0
TLS2_k127_3761802_18 Rieske-like [2Fe-2S] domain K05710 - - 0.0000000000000000000000000000000000000000000000001469 191.0
TLS2_k127_3761802_19 Protein conserved in bacteria K09962 - - 0.0000000000000008728 84.0
TLS2_k127_3761802_2 GMC oxidoreductase K00108 - 1.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005351 602.0
TLS2_k127_3761802_20 - - - - 0.0000000000001436 76.0
TLS2_k127_3761802_21 Nucleotidyltransferase K09962 - - 0.000002126 54.0
TLS2_k127_3761802_22 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000004739 52.0
TLS2_k127_3761802_3 Heparinase II/III-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 541.0
TLS2_k127_3761802_4 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008413 474.0
TLS2_k127_3761802_5 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 451.0
TLS2_k127_3761802_6 Patatin-like phospholipase K07001 GO:0003674,GO:0003824,GO:0016787 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 406.0
TLS2_k127_3761802_7 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 395.0
TLS2_k127_3761802_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 359.0
TLS2_k127_3761802_9 alpha/beta hydrolase fold K01561 - 3.8.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009839 352.0
TLS2_k127_3791656_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1036.0
TLS2_k127_3791656_1 carboxylic acid catabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 571.0
TLS2_k127_3791656_10 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000000000000000000001129 132.0
TLS2_k127_3791656_11 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.00000000000000000000000000000003967 129.0
TLS2_k127_3791656_12 - - - - 0.000000005931 61.0
TLS2_k127_3791656_2 histone deacetylase K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009011 455.0
TLS2_k127_3791656_3 Fumarylacetoacetate (FAA) hydrolase family K01826 - 5.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 408.0
TLS2_k127_3791656_4 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 412.0
TLS2_k127_3791656_5 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 378.0
TLS2_k127_3791656_6 Dehydrogenase K00008,K08322 GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034193,GO:0034195,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.14,1.1.1.380 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 368.0
TLS2_k127_3791656_7 Pilus formation protein N terminal region - - - 0.0000000000000000000000000000000000000000005124 162.0
TLS2_k127_3791656_8 PFAM Cupin 2 conserved barrel domain protein K21700 - - 0.000000000000000000000000000000000002637 143.0
TLS2_k127_3791656_9 NIPSNAP - - - 0.00000000000000000000000000000000003141 139.0
TLS2_k127_3798815_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1067.0
TLS2_k127_3798815_1 Bacterial extracellular solute-binding protein K05813 - - 4.987e-237 737.0
TLS2_k127_3798815_2 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816 - 3.6.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 448.0
TLS2_k127_3798815_3 Binding-protein-dependent transport system inner membrane component K05814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 424.0
TLS2_k127_3798815_4 probably responsible for the translocation of the substrate across the membrane K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 387.0
TLS2_k127_3798815_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000203 284.0
TLS2_k127_3798815_6 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit K11690 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001538 258.0
TLS2_k127_3798815_7 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.00000000002436 75.0
TLS2_k127_3798815_8 Trap-type c4-dicarboxylate transport system, small permease component - - - 0.0000003069 60.0
TLS2_k127_3798815_9 DNA polymerase K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0000007504 55.0
TLS2_k127_3802678_0 Acetolactate synthase K01652 - 2.2.1.6 0.0 1022.0
TLS2_k127_3802678_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 8.734e-300 928.0
TLS2_k127_3802678_10 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 340.0
TLS2_k127_3802678_11 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 304.0
TLS2_k127_3802678_12 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007182 302.0
TLS2_k127_3802678_13 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004686 287.0
TLS2_k127_3802678_14 Belongs to the UPF0173 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001904 278.0
TLS2_k127_3802678_15 Alpha/beta hydrolase family K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002063 270.0
TLS2_k127_3802678_16 Acetolactate synthase small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000004744 250.0
TLS2_k127_3802678_17 N-Acetylmuramoyl-L-alanine amidase K01448 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000004864 244.0
TLS2_k127_3802678_18 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000003234 204.0
TLS2_k127_3802678_19 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000001706 172.0
TLS2_k127_3802678_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 6.785e-280 882.0
TLS2_k127_3802678_20 - - - - 0.000000000000000000000000000000000000001977 149.0
TLS2_k127_3802678_21 Putative lumazine-binding - - - 0.0000000000000000000000000000000000006096 156.0
TLS2_k127_3802678_23 - - - - 0.000000000000000000000000000001396 126.0
TLS2_k127_3802678_4 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 424.0
TLS2_k127_3802678_5 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000712 394.0
TLS2_k127_3802678_6 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 373.0
TLS2_k127_3802678_7 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 361.0
TLS2_k127_3802678_8 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004577 364.0
TLS2_k127_3802678_9 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005808 349.0
TLS2_k127_3820610_0 Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 9.594e-202 638.0
TLS2_k127_3820610_1 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 327.0
TLS2_k127_3820610_2 NnrU protein - - - 0.0000000000000000000000000000000000000000000000000002884 199.0
TLS2_k127_3820610_3 membrane - - - 0.0000000000000000000000000000000000000000000001437 175.0
TLS2_k127_3820610_4 membrane transporter protein K07090 - - 0.0000000000008812 69.0
TLS2_k127_3873064_0 Penicillin acylase K01434 - 3.5.1.11 9.369e-254 807.0
TLS2_k127_3873064_1 TonB dependent receptor K16092 - - 1.292e-234 743.0
TLS2_k127_3873064_10 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002618 280.0
TLS2_k127_3873064_11 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000002036 241.0
TLS2_k127_3873064_12 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000006105 244.0
TLS2_k127_3873064_13 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000003968 228.0
TLS2_k127_3873064_14 TonB C terminal - - - 0.00000000000000000000000000000000000001351 157.0
TLS2_k127_3873064_15 Domain of unknown function (DUF1956) - - - 0.000000000000000000000000002759 112.0
TLS2_k127_3873064_2 Bacterial extracellular solute-binding protein - - - 4.822e-219 687.0
TLS2_k127_3873064_3 ABC transporter K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 592.0
TLS2_k127_3873064_4 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 561.0
TLS2_k127_3873064_5 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005582 505.0
TLS2_k127_3873064_6 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 492.0
TLS2_k127_3873064_7 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005652 449.0
TLS2_k127_3873064_8 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 375.0
TLS2_k127_3873064_9 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 314.0
TLS2_k127_3879303_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 522.0
TLS2_k127_3879303_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 426.0
TLS2_k127_3879303_2 Glycosyl transferase group 2 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002448 284.0
TLS2_k127_3879303_3 GrpB protein - - - 0.000000000000000000000000000000000000000000000000003344 187.0
TLS2_k127_3879303_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000001538 168.0
TLS2_k127_3879303_5 lactoylglutathione lyase activity - - - 0.00000000001408 70.0
TLS2_k127_3879303_6 Metallo-beta-lactamase superfamily - - - 0.00000003856 59.0
TLS2_k127_3885052_0 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 556.0
TLS2_k127_3885052_1 DNA methylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003721 279.0
TLS2_k127_3885052_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000006205 225.0
TLS2_k127_3885052_3 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.00000000000000000000000000000000000000000000000000000004015 207.0
TLS2_k127_3885052_4 Protein of unknown function DUF126 K09128 - - 0.000000000000000000000000000000000000000000111 175.0
TLS2_k127_3885052_5 Protein of unknown function (DUF1150) - - - 0.00000000000000000000000308 106.0
TLS2_k127_3885052_6 DNA methylase K00571 - 2.1.1.72 0.0000000000000000000001426 98.0
TLS2_k127_3921455_0 Extracellular solute-binding protein K02035 - - 4e-209 672.0
TLS2_k127_3921455_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 591.0
TLS2_k127_3921455_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 466.0
TLS2_k127_3921455_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 340.0
TLS2_k127_3921455_4 Invasion associated locus B (IalB) protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001181 275.0
TLS2_k127_3921455_6 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.00000000000000000000000000000000000000000000000000000556 193.0
TLS2_k127_3922066_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.219e-240 749.0
TLS2_k127_3922066_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 466.0
TLS2_k127_3922066_10 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000001101 226.0
TLS2_k127_3922066_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000002957 220.0
TLS2_k127_3922066_12 its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000703 188.0
TLS2_k127_3922066_13 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000002786 182.0
TLS2_k127_3922066_14 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000003903 171.0
TLS2_k127_3922066_15 Ribosomal protein S19 K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000000000006877 178.0
TLS2_k127_3922066_16 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000002504 156.0
TLS2_k127_3922066_17 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000007621 152.0
TLS2_k127_3922066_18 Ribosomal protein L23 K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000004456 147.0
TLS2_k127_3922066_19 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000001239 128.0
TLS2_k127_3922066_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 396.0
TLS2_k127_3922066_20 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000004305 101.0
TLS2_k127_3922066_21 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000002559 87.0
TLS2_k127_3922066_3 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009021 312.0
TLS2_k127_3922066_4 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 311.0
TLS2_k127_3922066_5 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 297.0
TLS2_k127_3922066_6 Belongs to the universal ribosomal protein uS5 family K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 286.0
TLS2_k127_3922066_7 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000005805 249.0
TLS2_k127_3922066_8 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000001279 234.0
TLS2_k127_3922066_9 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000008731 229.0
TLS2_k127_3930834_0 Binding-protein-dependent transport system inner membrane component - - - 6.99e-212 672.0
TLS2_k127_3930834_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 3.866e-200 633.0
TLS2_k127_3930834_2 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009337 541.0
TLS2_k127_3930834_3 TOBE domain K02010,K02052 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 448.0
TLS2_k127_3930834_4 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009977 389.0
TLS2_k127_3930834_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 372.0
TLS2_k127_3930834_6 Cold-shock protein K03704 - - 0.0000000000000000000000000001517 115.0
TLS2_k127_3930834_7 - - - - 0.00000000001734 73.0
TLS2_k127_39484_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 5.889e-272 847.0
TLS2_k127_39484_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 5.946e-194 615.0
TLS2_k127_39484_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 585.0
TLS2_k127_39484_3 Protein of unknown function (DUF2865) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 345.0
TLS2_k127_39484_4 EXOIII K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000006491 211.0
TLS2_k127_39484_5 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.0000000000000000000000000000000000000000002624 168.0
TLS2_k127_39484_6 Protein of unknown function (DUF1223) - - - 0.0000000000000001978 81.0
TLS2_k127_39484_7 Acetyltransferase, GNAT family - - - 0.000005648 56.0
TLS2_k127_3957432_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1405.0
TLS2_k127_3957432_1 Sulfite reductase K00381 - 1.8.1.2 1.975e-231 732.0
TLS2_k127_3957432_10 Bacterial periplasmic substrate-binding proteins K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000002451 258.0
TLS2_k127_3957432_11 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000000000000000000000000000003837 188.0
TLS2_k127_3957432_12 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.0000000000000000000005336 100.0
TLS2_k127_3957432_13 - - - - 0.0000000000006615 76.0
TLS2_k127_3957432_14 Tripartite tricarboxylate transporter TctA family K07793 - - 0.000000000003524 75.0
TLS2_k127_3957432_15 Protein of unknown function (DUF2849) - - - 0.0000006531 55.0
TLS2_k127_3957432_2 Formate dehydrogenase N, transmembrane K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 555.0
TLS2_k127_3957432_3 Sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008033 488.0
TLS2_k127_3957432_4 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 366.0
TLS2_k127_3957432_5 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 332.0
TLS2_k127_3957432_6 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 318.0
TLS2_k127_3957432_7 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 301.0
TLS2_k127_3957432_8 Prokaryotic cytochrome b561 K00127 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 293.0
TLS2_k127_3957432_9 Protein involved in formate dehydrogenase formation K02380 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000181 273.0
TLS2_k127_3960843_0 Hydantoinase B/oxoprolinase K01469 - 3.5.2.9 0.0 1631.0
TLS2_k127_3960843_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 541.0
TLS2_k127_3960843_10 Periplasmic protein thiol disulfide oxidoreductase K02199 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000001786 232.0
TLS2_k127_3960843_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000002299 171.0
TLS2_k127_3960843_12 - - - - 0.000000000000000000000000000000000000004025 154.0
TLS2_k127_3960843_13 invasion associated locus B - - - 0.000000000000000000000000000000000005787 144.0
TLS2_k127_3960843_14 COG4665 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.000000000000001126 86.0
TLS2_k127_3960843_15 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.00000000000006155 73.0
TLS2_k127_3960843_2 Alcohol dehydrogenase zinc-binding K00001,K00344 - 1.1.1.1,1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 426.0
TLS2_k127_3960843_3 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 421.0
TLS2_k127_3960843_4 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 375.0
TLS2_k127_3960843_5 Belongs to the D-glutamate cyclase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 369.0
TLS2_k127_3960843_6 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 345.0
TLS2_k127_3960843_7 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 306.0
TLS2_k127_3960843_8 rrna methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001289 266.0
TLS2_k127_3960843_9 integral membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005542 258.0
TLS2_k127_3985865_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 584.0
TLS2_k127_3985865_1 MiaB-like tRNA modifying enzyme K18707 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 536.0
TLS2_k127_3985865_10 Recombinase zinc beta ribbon domain - - - 0.0008002 42.0
TLS2_k127_3985865_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 467.0
TLS2_k127_3985865_3 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 418.0
TLS2_k127_3985865_4 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 380.0
TLS2_k127_3985865_5 probably involved in intracellular septation K06190 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000001402 221.0
TLS2_k127_3985865_6 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000002401 184.0
TLS2_k127_3985865_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000001864 176.0
TLS2_k127_3985865_8 Protein of unknown function (DUF1178) - - - 0.00000000000000000000000000000000000006933 148.0
TLS2_k127_3985865_9 Methyltransferase domain - - - 0.000000000000000000000002355 120.0
TLS2_k127_3989767_0 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 336.0
TLS2_k127_3989767_1 Sel1-like repeats. K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 304.0
TLS2_k127_3989767_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000004819 246.0
TLS2_k127_3989767_3 Peptidase C13 family - - - 0.0000000000000000000000000000000000000000000000000000000000003886 230.0
TLS2_k127_3989767_4 cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000000000000004605 198.0
TLS2_k127_3989767_5 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000475 132.0
TLS2_k127_3989767_6 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.000000000000000000000000409 108.0
TLS2_k127_3989767_7 DNA integration - - - 0.00002593 48.0
TLS2_k127_4009915_0 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 521.0
TLS2_k127_4009915_1 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 468.0
TLS2_k127_4009915_2 NlpC/P60 family - - - 0.000000000000000000000000000000000000000000000000000002022 199.0
TLS2_k127_4009915_3 chain release factor K15034 - - 0.00000000000000000000000000000000000000001407 158.0
TLS2_k127_4016627_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 614.0
TLS2_k127_4016627_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 608.0
TLS2_k127_4016627_10 Luciferase-like monooxygenase K14733 - 1.14.13.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 426.0
TLS2_k127_4016627_11 PFAM cyclase family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 414.0
TLS2_k127_4016627_12 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007923 411.0
TLS2_k127_4016627_13 plasmid maintenance K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 405.0
TLS2_k127_4016627_14 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 393.0
TLS2_k127_4016627_15 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 379.0
TLS2_k127_4016627_16 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 318.0
TLS2_k127_4016627_17 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 289.0
TLS2_k127_4016627_18 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000002233 238.0
TLS2_k127_4016627_19 Cupin domain - - - 0.000000000000000000000000000000000000000000000008115 174.0
TLS2_k127_4016627_2 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 571.0
TLS2_k127_4016627_20 HupE / UreJ protein K03192 - - 0.00000000000000000000000000000000000242 149.0
TLS2_k127_4016627_21 Protein of unknown function (DUF992) - - - 0.000000000000000000000000000000001519 140.0
TLS2_k127_4016627_22 Sterol carrier protein - - - 0.00000000000000000000000001043 122.0
TLS2_k127_4016627_3 acyl-CoA transferases carnitine dehydratase K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 543.0
TLS2_k127_4016627_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 530.0
TLS2_k127_4016627_5 Transporter associated domain K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 530.0
TLS2_k127_4016627_6 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 517.0
TLS2_k127_4016627_7 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162,K00627 - 1.2.4.1,2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 514.0
TLS2_k127_4016627_8 Belongs to the FPP GGPP synthase family K02523 GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 494.0
TLS2_k127_4016627_9 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 443.0
TLS2_k127_4081551_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 4.305e-261 814.0
TLS2_k127_4081551_1 Methionine synthase K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.00000000000000000000000000000000000000000000000000001263 195.0
TLS2_k127_4081551_2 Flp/Fap pilin component K02651 - - 0.0000000000122 66.0
TLS2_k127_4085078_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 356.0
TLS2_k127_4085078_1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K21395 - - 0.0000000000000000000000000000000000000000000000387 185.0
TLS2_k127_4085078_2 Zinc-binding dehydrogenase - - - 0.000000000000000000000000003709 111.0
TLS2_k127_4085078_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000001246 89.0
TLS2_k127_4091246_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 4.984e-317 981.0
TLS2_k127_4091246_1 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 6.704e-230 717.0
TLS2_k127_4091246_10 Thioesterase superfamily - - - 0.000000000000000000000000000000000000001481 151.0
TLS2_k127_4091246_11 Membrane fusogenic activity K09806 - - 0.0000000000000000000003138 98.0
TLS2_k127_4091246_12 - - - - 0.00000000000000004282 89.0
TLS2_k127_4091246_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 2.95e-201 634.0
TLS2_k127_4091246_3 ornithine cyclodeaminase activity K01750,K18258,K19244 - 1.4.1.1,1.5.1.25,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007785 311.0
TLS2_k127_4091246_4 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 295.0
TLS2_k127_4091246_5 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 287.0
TLS2_k127_4091246_6 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002206 282.0
TLS2_k127_4091246_7 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000003268 198.0
TLS2_k127_4091246_8 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000000000000000000000000000000008313 190.0
TLS2_k127_4091246_9 Protein of unknown function (DUF1465) K13592 - - 0.000000000000000000000000000000000000000000000000003636 188.0
TLS2_k127_412403_0 ABC transporter K15738 - - 7.4e-323 994.0
TLS2_k127_412403_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 3.191e-235 742.0
TLS2_k127_412403_10 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000003031 156.0
TLS2_k127_412403_2 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 1.193e-227 721.0
TLS2_k127_412403_3 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009477 422.0
TLS2_k127_412403_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006503 298.0
TLS2_k127_412403_5 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD K00788,K01447,K03806 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 2.5.1.3,3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003572 286.0
TLS2_k127_412403_6 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000000000000000014 262.0
TLS2_k127_412403_7 Tellurite resistance protein TerB K05801 - - 0.000000000000000000000000000000000000000000000000000000002344 207.0
TLS2_k127_412403_8 carbon monoxide dehydrogenase subunit G K09386 - - 0.000000000000000000000000000000000000000000000000000003373 201.0
TLS2_k127_412403_9 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000001759 173.0
TLS2_k127_4174054_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0 1190.0
TLS2_k127_4174054_1 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1129.0
TLS2_k127_4174054_10 Cytochrome c K17223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002708 248.0
TLS2_k127_4174054_11 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000000000000000000000000000000000000000000006472 244.0
TLS2_k127_4174054_12 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000000000000000000000000000000005078 230.0
TLS2_k127_4174054_13 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.000000000000000000000000000000000000005011 151.0
TLS2_k127_4174054_14 Belongs to the ompA family K03640 - - 0.0000000000000006459 91.0
TLS2_k127_4174054_15 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0002378 45.0
TLS2_k127_4174054_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.419e-241 756.0
TLS2_k127_4174054_3 Belongs to the 5'-nucleotidase family K17224 - - 5.472e-222 703.0
TLS2_k127_4174054_4 AMP-binding enzyme C-terminal domain - - - 6.717e-214 680.0
TLS2_k127_4174054_5 Penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 595.0
TLS2_k127_4174054_6 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019538,GO:0020037,GO:0022900,GO:0036211,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0071704,GO:0097159,GO:0098822,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004918 383.0
TLS2_k127_4174054_7 Rod shape-determining protein (MreB) K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 373.0
TLS2_k127_4174054_8 cytochrome c biogenesis protein K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 336.0
TLS2_k127_4174054_9 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000594 276.0
TLS2_k127_4237814_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 5.424e-229 736.0
TLS2_k127_4237814_1 Aminotransferase class I and II K14261,K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 384.0
TLS2_k127_4237814_2 Redoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000005965 194.0
TLS2_k127_4237814_3 Phasin protein - - - 0.00000000000000000000000000000000001239 141.0
TLS2_k127_4256529_0 Thiamine pyrophosphate enzyme, central domain - - - 4.7e-207 658.0
TLS2_k127_4256529_1 III protein, CoA-transferase family - - - 5.624e-201 631.0
TLS2_k127_4256529_10 - - - - 0.000000000000000000000000000000000000000000001289 170.0
TLS2_k127_4256529_11 chlorophyll binding K03286 - - 0.0000000000000000000000000004098 129.0
TLS2_k127_4256529_12 2TM domain - - - 0.00000000000000005802 83.0
TLS2_k127_4256529_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 487.0
TLS2_k127_4256529_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 473.0
TLS2_k127_4256529_4 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009297 391.0
TLS2_k127_4256529_5 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 353.0
TLS2_k127_4256529_6 D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 347.0
TLS2_k127_4256529_7 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 333.0
TLS2_k127_4256529_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003637 283.0
TLS2_k127_4256529_9 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000416 261.0
TLS2_k127_4264111_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 8.419e-254 790.0
TLS2_k127_4264111_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 7.86e-223 698.0
TLS2_k127_4264111_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 1.408e-214 669.0
TLS2_k127_4264111_3 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 5.012e-201 646.0
TLS2_k127_4264111_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 314.0
TLS2_k127_4264111_5 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000292 117.0
TLS2_k127_4264111_6 Transposase - - - 0.000001704 52.0
TLS2_k127_4267020_0 4Fe-4S dicluster domain - - - 1.125e-308 960.0
TLS2_k127_4267020_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 4.457e-299 937.0
TLS2_k127_4267020_10 TatD family K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 360.0
TLS2_k127_4267020_11 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 353.0
TLS2_k127_4267020_12 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 334.0
TLS2_k127_4267020_13 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 317.0
TLS2_k127_4267020_14 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000153 234.0
TLS2_k127_4267020_15 POTRA domain, FtsQ-type K03589 - - 0.0000000000009922 73.0
TLS2_k127_4267020_2 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 3.52e-246 770.0
TLS2_k127_4267020_3 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 1.211e-201 635.0
TLS2_k127_4267020_4 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 565.0
TLS2_k127_4267020_5 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 468.0
TLS2_k127_4267020_6 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 458.0
TLS2_k127_4267020_7 Prokaryotic glutathione synthetase, ATP-grasp domain K05844,K14940 - 6.3.2.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 458.0
TLS2_k127_4267020_8 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 449.0
TLS2_k127_4267020_9 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 401.0
TLS2_k127_4271678_0 PFAM Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009087 413.0
TLS2_k127_4271678_1 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 355.0
TLS2_k127_4271678_2 NLP P60 protein - - - 0.000000000000000000000000000000000000000336 151.0
TLS2_k127_4271678_4 Cytochrome c, class I K08738 - - 0.000002141 53.0
TLS2_k127_427898_0 Phosphate K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 614.0
TLS2_k127_427898_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 556.0
TLS2_k127_427898_2 PFAM FAD dependent oxidoreductase K03153 - 1.4.3.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 392.0
TLS2_k127_427898_3 Aldo/keto reductase family K00064 - 1.1.1.122 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 361.0
TLS2_k127_427898_4 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000996 299.0
TLS2_k127_427898_5 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000000000000000000008895 207.0
TLS2_k127_427898_6 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000001148 140.0
TLS2_k127_427898_7 Nucleoside 2-deoxyribosyltransferase - - - 0.0000000000000000000000000000000003592 136.0
TLS2_k127_427898_8 NUDIX domain K07766 - 3.6.1.52 0.0000000000000000000000000000000006554 136.0
TLS2_k127_427898_9 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000006032 54.0
TLS2_k127_430531_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 414.0
TLS2_k127_430531_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000003868 223.0
TLS2_k127_430531_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000001061 213.0
TLS2_k127_430531_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000004889 152.0
TLS2_k127_4324534_0 Belongs to the citrate synthase family K01647,K01659 - 2.3.3.1,2.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007998 597.0
TLS2_k127_4324534_1 Periplasmic binding protein K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006685 494.0
TLS2_k127_4324534_10 ABC transporter, ATP-binding protein K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006519 271.0
TLS2_k127_4324534_11 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008828 265.0
TLS2_k127_4324534_12 PRC-barrel domain - - - 0.00000000000000000000000000000000000000000000000000002735 189.0
TLS2_k127_4324534_13 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000001976 183.0
TLS2_k127_4324534_14 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000000000000007474 171.0
TLS2_k127_4324534_15 Malate/L-lactate dehydrogenase K00073,K13574 - 1.1.1.350 0.000000000000000000000000000000000000002319 148.0
TLS2_k127_4324534_16 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000009676 159.0
TLS2_k127_4324534_17 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000002157 122.0
TLS2_k127_4324534_18 location bacterial cytoplasm Psort-Score 0.0959 - - - 0.0000000000000000000002307 100.0
TLS2_k127_4324534_19 PRC-barrel domain - - - 0.0000000000000000124 90.0
TLS2_k127_4324534_2 COG4664 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 451.0
TLS2_k127_4324534_3 L-phenylalanine transmembrane transporter activity K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002342 402.0
TLS2_k127_4324534_4 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005728 326.0
TLS2_k127_4324534_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 313.0
TLS2_k127_4324534_6 PFAM amidohydrolase 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 306.0
TLS2_k127_4324534_7 phosphate acetyltransferase K00625 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 327.0
TLS2_k127_4324534_8 transport system periplasmic component K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 291.0
TLS2_k127_4324534_9 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005225 285.0
TLS2_k127_4357998_0 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 0.0 1011.0
TLS2_k127_4357998_1 TRAP transporter, 4TM 12TM fusion protein - - - 1.066e-219 700.0
TLS2_k127_4357998_10 Hydrogenase urease accessory protein K03192 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000004227 168.0
TLS2_k127_4357998_11 Belongs to the urease gamma subunit family K01430,K14048 - 3.5.1.5 0.000000000000000000000000000000000000000006751 166.0
TLS2_k127_4357998_12 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.00000002945 57.0
TLS2_k127_4357998_2 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 624.0
TLS2_k127_4357998_3 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 557.0
TLS2_k127_4357998_4 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 385.0
TLS2_k127_4357998_5 TRAP transporter, solute receptor (TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 382.0
TLS2_k127_4357998_6 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001006 276.0
TLS2_k127_4357998_7 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.00000000000000000000000000000000000000000000000000000000000000000003854 241.0
TLS2_k127_4357998_8 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000009535 196.0
TLS2_k127_4357998_9 Belongs to the urease gamma subunit family K01430,K14048 - 3.5.1.5 0.0000000000000000000000000000000000000000000000000009876 186.0
TLS2_k127_4519163_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1096.0
TLS2_k127_4519163_1 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 325.0
TLS2_k127_4519163_2 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001294 267.0
TLS2_k127_4519163_3 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003756 256.0
TLS2_k127_4519163_4 COG2940 Proteins containing SET domain K07117 - - 0.000000000000000000000000000000000000000003212 159.0
TLS2_k127_4520546_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 549.0
TLS2_k127_4520546_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 492.0
TLS2_k127_4520546_10 Clp amino terminal domain, pathogenicity island component - - - 0.00000000000000000002464 98.0
TLS2_k127_4520546_2 PFAM HI0933 family protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 438.0
TLS2_k127_4520546_3 Pyrimidine 5'-nucleotidase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 336.0
TLS2_k127_4520546_4 Cold-shock K03704 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 325.0
TLS2_k127_4520546_5 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005169 255.0
TLS2_k127_4520546_6 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000004052 250.0
TLS2_k127_4520546_7 Disulfide bond formation protein DsbB K03611 - - 0.000000000000000000000000000000000000000000000000000001406 196.0
TLS2_k127_4520546_8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000006565 152.0
TLS2_k127_4520546_9 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000006878 156.0
TLS2_k127_4575227_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 2.036e-232 729.0
TLS2_k127_4575227_1 cell division ATP-binding protein FtsE K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 365.0
TLS2_k127_4575227_2 Cell division protein K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 368.0
TLS2_k127_4575227_3 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000008455 225.0
TLS2_k127_4622752_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 2.431e-248 775.0
TLS2_k127_4622752_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 6.895e-194 611.0
TLS2_k127_4622752_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005903 476.0
TLS2_k127_4622752_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 469.0
TLS2_k127_4622752_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006508 312.0
TLS2_k127_4622752_5 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000188 241.0
TLS2_k127_4622752_6 Domain of unknown function (DUF4384) - - - 0.0000000000000000000000198 116.0
TLS2_k127_4724324_0 Receptor family ligand binding region - - - 3.528e-219 691.0
TLS2_k127_4724324_1 Alpha beta hydrolase fold K01048 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 406.0
TLS2_k127_4724324_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 358.0
TLS2_k127_4724324_3 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009255 342.0
TLS2_k127_4724324_4 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 334.0
TLS2_k127_4724324_5 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 321.0
TLS2_k127_4724324_6 Histidine kinase K11357 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 296.0
TLS2_k127_4724324_7 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000004054 235.0
TLS2_k127_4724324_8 Belongs to the UPF0335 family - - - 0.00000000000000017 80.0
TLS2_k127_4724324_9 Putative peptidoglycan binding domain - - - 0.00000007594 61.0
TLS2_k127_4732745_0 Bacterial protein of unknown function (DUF853) K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 625.0
TLS2_k127_4732745_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006614 441.0
TLS2_k127_4732745_10 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000000000000000001694 154.0
TLS2_k127_4732745_11 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000004859 152.0
TLS2_k127_4732745_12 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000000001855 117.0
TLS2_k127_4732745_13 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000006874 83.0
TLS2_k127_4732745_2 FES K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008782 325.0
TLS2_k127_4732745_3 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 325.0
TLS2_k127_4732745_4 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000811 282.0
TLS2_k127_4732745_5 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002154 250.0
TLS2_k127_4732745_6 3-hydroxyacyl-coa dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000002677 190.0
TLS2_k127_4732745_7 16S RNA G1207 methylase RsmC K00564 - 2.1.1.172 0.00000000000000000000000000000000000000000000000000004778 201.0
TLS2_k127_4732745_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000002601 159.0
TLS2_k127_4732745_9 Integral membrane protein (DUF2244) - - - 0.000000000000000000000000000000000000000004649 171.0
TLS2_k127_4750346_0 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 551.0
TLS2_k127_4750346_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008433 516.0
TLS2_k127_4750346_2 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009333 494.0
TLS2_k127_4750346_3 Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 439.0
TLS2_k127_4750346_4 Gluconolactonase K01053,K14274 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 318.0
TLS2_k127_4756987_0 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 572.0
TLS2_k127_4756987_1 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 507.0
TLS2_k127_4756987_10 Membrane protein implicated in regulation of membrane protease activity K07340 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000008249 88.0
TLS2_k127_4756987_11 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000003579 66.0
TLS2_k127_4756987_2 prohibitin homologues - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 471.0
TLS2_k127_4756987_3 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 462.0
TLS2_k127_4756987_4 Sigma-54 interaction domain K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 432.0
TLS2_k127_4756987_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 366.0
TLS2_k127_4756987_6 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000009995 174.0
TLS2_k127_4756987_7 NfeD-like C-terminal, partner-binding K07340 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000002744 152.0
TLS2_k127_4756987_8 - - - - 0.00000000000000000000000000000000006994 145.0
TLS2_k127_4756987_9 MarR family - - - 0.000000000000000000000000000001755 132.0
TLS2_k127_4762044_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088,K00364 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205,1.7.1.7 2.017e-232 731.0
TLS2_k127_4762044_1 Predicted membrane protein (DUF2339) - - - 4.687e-196 643.0
TLS2_k127_4762044_10 TIGRFAM pilus (Caulobacter type) biogenesis lipoprotein CpaD K02281 - - 0.0000000000000000000000000000000000000000000000000000000000491 213.0
TLS2_k127_4762044_11 Peptidase A24A, prepilin type IV K02278 - 3.4.23.43 0.0000000000000000000000000000000000000000000000001666 181.0
TLS2_k127_4762044_12 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000001085 175.0
TLS2_k127_4762044_13 AAA domain K02282 - - 0.0000000006756 61.0
TLS2_k127_4762044_14 Flp pilus assembly protein, pilin Flp K02651 - - 0.00000001307 60.0
TLS2_k127_4762044_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 555.0
TLS2_k127_4762044_3 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 547.0
TLS2_k127_4762044_4 Initiation factor 2 subunit family K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 497.0
TLS2_k127_4762044_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 496.0
TLS2_k127_4762044_6 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 348.0
TLS2_k127_4762044_7 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 347.0
TLS2_k127_4762044_8 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 325.0
TLS2_k127_4762044_9 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003639 266.0
TLS2_k127_4764018_0 Molybdopterin oxidoreductase Fe4S4 domain K21307 - 1.8.5.6 0.0 1439.0
TLS2_k127_4764018_1 Belongs to the GcvT family K00302 - 1.5.3.1 0.0 1416.0
TLS2_k127_4764018_10 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 342.0
TLS2_k127_4764018_11 DMSO reductase anchor subunit K21309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005204 330.0
TLS2_k127_4764018_12 PFAM amidohydrolase 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 319.0
TLS2_k127_4764018_13 COG0583 Transcriptional regulator K03566 - - 0.00000000000000000000000000000000000000000000000000000004058 207.0
TLS2_k127_4764018_14 Sarcosine oxidase, delta subunit K00304 - 1.5.3.1 0.0000000000000000000000000000000000000000003205 160.0
TLS2_k127_4764018_15 Sarcosine oxidase, gamma subunit family K00305 - 1.5.3.1 0.000000000000000000000000000000000000008559 154.0
TLS2_k127_4764018_2 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 3.83e-249 786.0
TLS2_k127_4764018_3 Sarcosine oxidase, beta subunit K00303 - 1.5.3.1 1.751e-232 723.0
TLS2_k127_4764018_4 GDP-mannose 4,6 dehydratase K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 497.0
TLS2_k127_4764018_5 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 452.0
TLS2_k127_4764018_6 4Fe-4S dicluster domain K00124,K21308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 426.0
TLS2_k127_4764018_7 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007813 424.0
TLS2_k127_4764018_8 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 352.0
TLS2_k127_4764018_9 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 346.0
TLS2_k127_4765731_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 2.595e-201 634.0
TLS2_k127_4765731_1 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 405.0
TLS2_k127_4765731_2 dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 407.0
TLS2_k127_4765731_3 DNA polymerase III chi subunit K02339 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000004379 218.0
TLS2_k127_4765731_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000000000000003726 203.0
TLS2_k127_4765731_5 oxidation-reduction process - - - 0.0000000000000000000000000000000000001321 155.0
TLS2_k127_4765731_6 - - - - 0.000000000000000000000000000000000002571 149.0
TLS2_k127_4776463_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 6.904e-319 979.0
TLS2_k127_4776463_1 malic enzyme K00029 - 1.1.1.40 5.311e-306 955.0
TLS2_k127_4776463_10 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007413 352.0
TLS2_k127_4776463_11 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 349.0
TLS2_k127_4776463_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 335.0
TLS2_k127_4776463_13 Short-chain dehydrogenase reductase SDR K00076 - 1.1.1.159 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 302.0
TLS2_k127_4776463_14 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000005524 227.0
TLS2_k127_4776463_15 domain, Protein K18491 - - 0.00000000000000000000000000000000000000000008743 178.0
TLS2_k127_4776463_16 Belongs to the HesB IscA family K13628,K15724 - - 0.0000000000000000000000000000000000000004699 154.0
TLS2_k127_4776463_17 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 0.0000000000000000000000000000000000109 138.0
TLS2_k127_4776463_18 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000000000003588 126.0
TLS2_k127_4776463_2 Arginyl-tRNA synthetase K01887 - 6.1.1.19 3.162e-247 777.0
TLS2_k127_4776463_20 - - - - 0.00000003709 61.0
TLS2_k127_4776463_3 Chromate transporter K07240 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 482.0
TLS2_k127_4776463_4 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008996 467.0
TLS2_k127_4776463_5 SurA N-terminal domain K01802,K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 474.0
TLS2_k127_4776463_6 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 430.0
TLS2_k127_4776463_7 COG0607 Rhodanese-related sulfurtransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 404.0
TLS2_k127_4776463_8 Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 396.0
TLS2_k127_4776463_9 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 375.0
TLS2_k127_4780698_0 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00362 - 1.7.1.15 0.0 1296.0
TLS2_k127_4780698_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.0 1084.0
TLS2_k127_4780698_10 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 422.0
TLS2_k127_4780698_11 helix_turn _helix lactose operon repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004993 398.0
TLS2_k127_4780698_12 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 308.0
TLS2_k127_4780698_13 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000005044 240.0
TLS2_k127_4780698_14 COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs K03519,K11178 - 1.17.1.4,1.2.5.3 0.00000000000000000000000000000000000000000000000000000000002618 220.0
TLS2_k127_4780698_15 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000175 207.0
TLS2_k127_4780698_16 Rieske-like [2Fe-2S] domain K00363 - 1.7.1.15 0.00000000000000000000000000000000000000000000009261 171.0
TLS2_k127_4780698_17 location bacterial cytoplasm Psort-Score 0.0959 - - - 0.0000299 48.0
TLS2_k127_4780698_2 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs - - - 0.0 1082.0
TLS2_k127_4780698_3 ABC transporter K02049,K15578 - - 5.551e-263 821.0
TLS2_k127_4780698_4 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 1.186e-208 669.0
TLS2_k127_4780698_5 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 556.0
TLS2_k127_4780698_6 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K15576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 541.0
TLS2_k127_4780698_7 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 526.0
TLS2_k127_4780698_8 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 533.0
TLS2_k127_4780698_9 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050,K15577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009386 499.0
TLS2_k127_4802107_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1061.0
TLS2_k127_4802107_1 lipid A ABC exporter family, fused ATPase and inner membrane subunits K06147 - - 5.854e-230 727.0
TLS2_k127_4802107_10 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000006128 256.0
TLS2_k127_4802107_11 alpha/beta hydrolase fold K01432 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000009087 239.0
TLS2_k127_4802107_12 COG0563 Adenylate kinase and related kinases - - - 0.00000000000000000000000000000000000000000000000000000000000000001251 229.0
TLS2_k127_4802107_13 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000001957 220.0
TLS2_k127_4802107_14 Phosphomethylpyrimidine kinase K00868 - 2.7.1.35 0.00000000000000000000000000000000000000000000000000000000009641 218.0
TLS2_k127_4802107_15 tetR family - - - 0.000000000000000000000000000000000000000000000000000183 195.0
TLS2_k127_4802107_17 phasin family - - - 0.0000000000000000000000000000000000000000001455 162.0
TLS2_k127_4802107_18 Lipid A oxidase K12980 - - 0.000000000000000000000000000000000000000001317 165.0
TLS2_k127_4802107_19 Phasin protein - - - 0.000000000000000000000000000000000000004264 149.0
TLS2_k127_4802107_2 Thermophilic metalloprotease (M29) K19689 - - 1.335e-224 709.0
TLS2_k127_4802107_20 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000005787 133.0
TLS2_k127_4802107_21 - - - - 0.0000000000000000000000000001305 125.0
TLS2_k127_4802107_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 612.0
TLS2_k127_4802107_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 522.0
TLS2_k127_4802107_5 lytic murein transglycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 400.0
TLS2_k127_4802107_6 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 392.0
TLS2_k127_4802107_7 Belongs to the peptidase S11 family K01286 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 342.0
TLS2_k127_4802107_8 LexA-binding, inner membrane-associated putative hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 316.0
TLS2_k127_4802107_9 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 286.0
TLS2_k127_4827445_0 histidine kinase A domain protein - - - 0.0 1187.0
TLS2_k127_4827445_1 - - - - 1.086e-251 799.0
TLS2_k127_4827445_10 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 392.0
TLS2_k127_4827445_11 ArgK protein K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 367.0
TLS2_k127_4827445_12 Belongs to the UPF0271 (lamB) family K07160 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 356.0
TLS2_k127_4827445_13 allophanate hydrolase subunit 2 K01457 - 3.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008149 334.0
TLS2_k127_4827445_14 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 329.0
TLS2_k127_4827445_15 Histidine Phosphotransfer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 342.0
TLS2_k127_4827445_16 helix_turn_helix, Lux Regulon - GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002994 280.0
TLS2_k127_4827445_17 Allophanate hydrolase, subunit 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002901 263.0
TLS2_k127_4827445_18 response regulator K02485 - - 0.000000000000000000000000000000000000000000000000000004643 193.0
TLS2_k127_4827445_19 Protein of unknown function (DUF1153) - - - 0.000000000000000000000000000000000000000000000001576 174.0
TLS2_k127_4827445_2 Cytochrome P450 - - - 1.484e-208 653.0
TLS2_k127_4827445_20 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000000001919 160.0
TLS2_k127_4827445_21 Domain of unknown function (DUF4212) K14393 - - 0.00000000000000000000000000000000000252 142.0
TLS2_k127_4827445_22 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000001418 142.0
TLS2_k127_4827445_23 Belongs to the Nudix hydrolase family - - - 0.000000000000000000000000001299 117.0
TLS2_k127_4827445_24 flagellar export protein FliJ - - - 0.00000000000000000000000004584 111.0
TLS2_k127_4827445_25 4Fe-4S single cluster domain of Ferredoxin I K05337 - - 0.0000000000000000000000001303 107.0
TLS2_k127_4827445_26 Putative cyclase - - - 0.0000000000000000000000004881 108.0
TLS2_k127_4827445_27 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.00000000000000000000008827 102.0
TLS2_k127_4827445_28 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000002642 102.0
TLS2_k127_4827445_29 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0003674,GO:0005215 - 0.0000000000000001406 87.0
TLS2_k127_4827445_3 Valyl tRNA synthetase tRNA binding arm K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 5.554e-206 651.0
TLS2_k127_4827445_30 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0003674,GO:0005215 - 0.0000000000000001567 81.0
TLS2_k127_4827445_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 2.49e-196 621.0
TLS2_k127_4827445_5 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 534.0
TLS2_k127_4827445_6 MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 462.0
TLS2_k127_4827445_7 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 449.0
TLS2_k127_4827445_8 two component transcriptional regulator K02483,K13584 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 440.0
TLS2_k127_4827445_9 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 438.0
TLS2_k127_4869116_0 Hydantoinase/oxoprolinase N-terminal region K01469,K01473 - 3.5.2.14,3.5.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 503.0
TLS2_k127_4869116_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 481.0
TLS2_k127_4869116_2 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 296.0
TLS2_k127_4869116_3 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000003139 224.0
TLS2_k127_4869116_4 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000006197 89.0
TLS2_k127_4869392_0 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 9.873e-229 716.0
TLS2_k127_4869392_1 Aminotransferase K00812 - 2.6.1.1 1.369e-199 628.0
TLS2_k127_4869392_10 Protein of unknown function (FYDLN_acid) - - - 0.000000000000000000000000000001365 124.0
TLS2_k127_4869392_11 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000126 102.0
TLS2_k127_4869392_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 560.0
TLS2_k127_4869392_3 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 361.0
TLS2_k127_4869392_4 succinylglutamate desuccinylase K06987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 365.0
TLS2_k127_4869392_5 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 319.0
TLS2_k127_4869392_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009038 314.0
TLS2_k127_4869392_7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000008975 237.0
TLS2_k127_4869392_8 PFAM Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000001682 145.0
TLS2_k127_4869392_9 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000001377 128.0
TLS2_k127_4889999_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 613.0
TLS2_k127_4889999_1 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 384.0
TLS2_k127_4889999_10 - - - - 0.000000000000000002451 89.0
TLS2_k127_4889999_11 sh3 domain protein - - - 0.0000000000000002277 89.0
TLS2_k127_4889999_2 HlyD membrane-fusion protein of T1SS - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 368.0
TLS2_k127_4889999_3 MazG nucleotide pyrophosphohydrolase domain K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 346.0
TLS2_k127_4889999_4 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 308.0
TLS2_k127_4889999_5 DnaJ molecular chaperone homology domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006781 261.0
TLS2_k127_4889999_6 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000004647 260.0
TLS2_k127_4889999_7 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000009888 183.0
TLS2_k127_4889999_8 Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP K01004 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576 2.7.8.24 0.00000000000000000000000000000000000000000000000001708 188.0
TLS2_k127_4889999_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000001348 150.0
TLS2_k127_4896086_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 5.963e-246 766.0
TLS2_k127_4896086_1 biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 458.0
TLS2_k127_4896086_2 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004972 450.0
TLS2_k127_4896086_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 304.0
TLS2_k127_4896086_4 protein conserved in bacteria K09974 - - 0.0000000000000000000000000000000000000000000000000000000000000115 221.0
TLS2_k127_4896086_5 ABC transporter substrate binding protein - - - 0.0000000000000000000000000000000000000002542 162.0
TLS2_k127_4900046_0 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 562.0
TLS2_k127_4900046_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008612 546.0
TLS2_k127_4900046_2 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000004776 229.0
TLS2_k127_4900046_3 Uncharacterised MFS-type transporter YbfB - - - 0.0000000000000000000000000000000000000000000000000000000000000000542 245.0
TLS2_k127_4900046_4 conserved protein UCP033924 - - - 0.000000000000000000000000000002098 131.0
TLS2_k127_4900046_5 required for the assembly of the mitochondrial F1-ATPase - - - 0.00000000000000000000000001189 113.0
TLS2_k127_4900960_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1268.0
TLS2_k127_4900960_1 serine threonine protein kinase K08282 - 2.7.11.1 6.402e-239 764.0
TLS2_k127_4900960_2 COG0277 FAD FMN-containing dehydrogenases K00102 - 1.1.2.4 1.215e-198 629.0
TLS2_k127_4900960_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008971 533.0
TLS2_k127_4900960_4 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 491.0
TLS2_k127_4900960_5 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008331 381.0
TLS2_k127_4900960_7 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.0000000000000003261 79.0
TLS2_k127_4900960_8 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000007366 79.0
TLS2_k127_4902203_0 Transketolase, pyrimidine binding domain K11381,K21416 - 1.2.4.4 3.648e-265 840.0
TLS2_k127_4902203_1 Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source K01505,K05396 - 3.5.99.7,4.4.1.15 2.576e-209 652.0
TLS2_k127_4902203_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000001485 186.0
TLS2_k127_4902203_11 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000007319 153.0
TLS2_k127_4902203_12 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000006445 155.0
TLS2_k127_4902203_13 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.00008328 46.0
TLS2_k127_4902203_14 Domain of unknown function (DUF1127) - - - 0.0005712 47.0
TLS2_k127_4902203_2 Cytochrome P450 K15468 - - 1.534e-207 652.0
TLS2_k127_4902203_3 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007324 449.0
TLS2_k127_4902203_4 Sugar (and other) transporter K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 439.0
TLS2_k127_4902203_5 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 343.0
TLS2_k127_4902203_6 HlyD membrane-fusion protein of T1SS - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 300.0
TLS2_k127_4902203_7 WYL domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 286.0
TLS2_k127_4902203_8 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K03719 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007553 259.0
TLS2_k127_4902203_9 Cysteine methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000002176 205.0
TLS2_k127_4922706_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 3.108e-241 749.0
TLS2_k127_4922706_1 Uncharacterized protein conserved in bacteria (DUF2130) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 590.0
TLS2_k127_4922706_10 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000006862 222.0
TLS2_k127_4922706_11 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000002503 205.0
TLS2_k127_4922706_12 - - - - 0.00000000000000000000000003023 116.0
TLS2_k127_4922706_15 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000008032 55.0
TLS2_k127_4922706_2 Alanine-glyoxylate amino-transferase K00375,K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007783 555.0
TLS2_k127_4922706_3 HemN C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004484 491.0
TLS2_k127_4922706_4 Zinc-binding dehydrogenase K00344 GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003960,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016651,GO:0016655,GO:0017091,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:1901363 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 452.0
TLS2_k127_4922706_5 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 342.0
TLS2_k127_4922706_6 Thioredoxin-like [2Fe-2S] ferredoxin K00334,K03943 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 316.0
TLS2_k127_4922706_7 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 300.0
TLS2_k127_4922706_8 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003868 269.0
TLS2_k127_4922706_9 Protein of unknown function (DUF1134) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005298 276.0
TLS2_k127_4960725_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 8.748e-271 844.0
TLS2_k127_4960725_1 cytochrome P450 - - - 2.172e-229 722.0
TLS2_k127_4960725_2 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003973 547.0
TLS2_k127_4960725_3 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 526.0
TLS2_k127_4960725_4 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000746 292.0
TLS2_k127_4960725_5 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000007789 259.0
TLS2_k127_4960725_6 RES - - - 0.000000000000000000000000000000000000000000000008217 177.0
TLS2_k127_4960725_7 Protein of unknown function (DUF2384) - - - 0.00000000000000001823 88.0
TLS2_k127_4960725_8 Transposase K07481 - - 0.0001373 48.0
TLS2_k127_4980825_0 Putative amidoligase enzyme (DUF2126) - - - 0.0 1716.0
TLS2_k127_4980825_1 Circularly permuted ATP-grasp type 2 - - - 0.0 1124.0
TLS2_k127_4980825_10 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000153 250.0
TLS2_k127_4980825_11 SnoaL-like polyketide cyclase K07255 - - 0.000000000000000000000000000000000000000000000000000000000000000003058 237.0
TLS2_k127_4980825_12 Thioredoxin-like domain - - - 0.000000000000000000000000000000000000000000000000003759 190.0
TLS2_k127_4980825_13 methionine sulfoxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000004937 188.0
TLS2_k127_4980825_14 UTRA K03710 - - 0.0000000000000000000000000000000000000000002812 169.0
TLS2_k127_4980825_15 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000001704 106.0
TLS2_k127_4980825_2 DEAD/H associated K03724 - - 0.0 1116.0
TLS2_k127_4980825_3 Helicase - - - 8.981e-207 654.0
TLS2_k127_4980825_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 505.0
TLS2_k127_4980825_5 mandelate racemase muconate lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007985 502.0
TLS2_k127_4980825_6 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 396.0
TLS2_k127_4980825_7 PRMT5 oligomerisation domain K11434 - 2.1.1.319 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 341.0
TLS2_k127_4980825_8 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 342.0
TLS2_k127_4980825_9 ICC-like phosphoesterases K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 325.0
TLS2_k127_4985524_0 Belongs to the TPP enzyme family K01577,K01652 - 2.2.1.6,4.1.1.8 0.0 1046.0
TLS2_k127_4985524_1 protein conserved in bacteria K07793 - - 1.065e-245 766.0
TLS2_k127_4985524_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.498e-197 631.0
TLS2_k127_4985524_3 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 497.0
TLS2_k127_4985524_4 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 394.0
TLS2_k127_4985524_5 Regulatory protein GntR HTH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 299.0
TLS2_k127_4985524_6 Hemimethylated DNA-binding protein YccV like K11940 - - 0.000000000000000000000000000000000000000000000000201 179.0
TLS2_k127_4985524_7 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000000000000000000000001744 167.0
TLS2_k127_4985524_8 - - - - 0.00000000000004433 77.0
TLS2_k127_4994147_0 ABC-type dipeptide transport system periplasmic component K02035 - - 4.18e-308 948.0
TLS2_k127_4994147_1 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 1.416e-258 809.0
TLS2_k127_4994147_2 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 516.0
TLS2_k127_4994147_3 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 518.0
TLS2_k127_4994147_4 Oligopeptide/dipeptide transporter, C-terminal region K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 484.0
TLS2_k127_4994147_5 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 426.0
TLS2_k127_4994147_6 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 371.0
TLS2_k127_5041515_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009498 536.0
TLS2_k127_5041515_1 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008529 406.0
TLS2_k127_5041515_2 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002216 285.0
TLS2_k127_5041515_3 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002019 276.0
TLS2_k127_5041515_4 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001284 264.0
TLS2_k127_5041515_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000004806 126.0
TLS2_k127_5056304_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 563.0
TLS2_k127_5056304_1 permease YjgP YjgQ K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006626 385.0
TLS2_k127_5056304_2 FAD binding domain K00480 - 1.14.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008633 347.0
TLS2_k127_5056304_3 permease YjgP YjgQ family protein K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 347.0
TLS2_k127_5056304_4 Alpha beta hydrolase K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 336.0
TLS2_k127_5056304_5 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 324.0
TLS2_k127_5056304_6 Zinc-finger domain - - - 0.000000000000000000000000000000000999 133.0
TLS2_k127_5098224_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.342e-298 923.0
TLS2_k127_5098224_1 phosphatase K07093 - - 2.59e-277 868.0
TLS2_k127_5098224_10 COG1062 Zn-dependent alcohol dehydrogenases, class III K00001,K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 463.0
TLS2_k127_5098224_11 MotA TolQ ExbB proton channel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 431.0
TLS2_k127_5098224_12 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 432.0
TLS2_k127_5098224_13 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 412.0
TLS2_k127_5098224_14 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 403.0
TLS2_k127_5098224_15 inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007501 383.0
TLS2_k127_5098224_16 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 346.0
TLS2_k127_5098224_17 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 344.0
TLS2_k127_5098224_18 Belongs to the DapA family K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 343.0
TLS2_k127_5098224_19 geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 328.0
TLS2_k127_5098224_2 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 3.743e-205 650.0
TLS2_k127_5098224_20 Glutathione S-transferase, N-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 324.0
TLS2_k127_5098224_21 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009596 320.0
TLS2_k127_5098224_22 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000969 312.0
TLS2_k127_5098224_23 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 304.0
TLS2_k127_5098224_24 COG1838 Tartrate dehydratase beta subunit Fumarate hydratase class I, C-terminal domain K03780 - 4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 291.0
TLS2_k127_5098224_25 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006738 269.0
TLS2_k127_5098224_26 Extensin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003278 244.0
TLS2_k127_5098224_27 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000003427 224.0
TLS2_k127_5098224_28 Uncharacterised protein family (UPF0262) - - - 0.00000000000000000000000000000000000000000000000000000000005194 210.0
TLS2_k127_5098224_29 carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000000000832 209.0
TLS2_k127_5098224_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 605.0
TLS2_k127_5098224_30 Belongs to the Fur family K09826 - - 0.0000000000000000000000000000000000000000000000000000001564 199.0
TLS2_k127_5098224_31 Low molecular weight phosphatase family K01104,K03741 - 1.20.4.1,3.1.3.48 0.000000000000000000000000000000000000000000000000000002582 194.0
TLS2_k127_5098224_32 - - - - 0.000000000000000000000000000000000000000000000000005649 192.0
TLS2_k127_5098224_33 ChrR Cupin-like domain - - - 0.00000000000000000000000000000000000000000000000002786 182.0
TLS2_k127_5098224_34 Protein of unknown function (DUF2948) - - - 0.000000000000000000000000000000000000000000000001462 178.0
TLS2_k127_5098224_35 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.00000000000000000000000000000000000000000002978 173.0
TLS2_k127_5098224_36 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000005891 163.0
TLS2_k127_5098224_37 Membrane K03646 - - 0.0000000000000000000000000000000000000203 162.0
TLS2_k127_5098224_38 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000002339 139.0
TLS2_k127_5098224_39 - - - - 0.000000000000000000000000002173 117.0
TLS2_k127_5098224_4 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 591.0
TLS2_k127_5098224_41 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000002842 107.0
TLS2_k127_5098224_42 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.00000001028 58.0
TLS2_k127_5098224_43 - - - - 0.0000001562 57.0
TLS2_k127_5098224_44 - - - - 0.000001297 52.0
TLS2_k127_5098224_45 - - - - 0.00007426 52.0
TLS2_k127_5098224_5 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 568.0
TLS2_k127_5098224_6 SMP-30/Gluconolaconase/LRE-like region K01053,K14274 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 526.0
TLS2_k127_5098224_7 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 499.0
TLS2_k127_5098224_8 OmpA family K02557 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008076 483.0
TLS2_k127_5098224_9 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 479.0
TLS2_k127_5115036_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 5.881e-291 899.0
TLS2_k127_5115036_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903,K14067 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5,6.2.1.9 8.212e-203 637.0
TLS2_k127_5115036_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 303.0
TLS2_k127_5115036_11 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 306.0
TLS2_k127_5115036_12 May be involved in the biosynthesis of molybdopterin K03638 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 2.7.7.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001658 280.0
TLS2_k127_5115036_13 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007979 286.0
TLS2_k127_5115036_14 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000009434 252.0
TLS2_k127_5115036_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000145 257.0
TLS2_k127_5115036_16 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000967 210.0
TLS2_k127_5115036_17 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000002633 207.0
TLS2_k127_5115036_18 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000000000000000000000000000000000002091 175.0
TLS2_k127_5115036_19 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000005838 143.0
TLS2_k127_5115036_2 Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 456.0
TLS2_k127_5115036_20 SnoaL-like domain - - - 0.000000000000000000000000000003483 123.0
TLS2_k127_5115036_23 - - - - 0.0000006704 57.0
TLS2_k127_5115036_3 PFAM aldo keto reductase K05882 - 1.1.1.91 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 428.0
TLS2_k127_5115036_4 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009123 420.0
TLS2_k127_5115036_5 Nitronate monooxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 385.0
TLS2_k127_5115036_6 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009326 350.0
TLS2_k127_5115036_7 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 329.0
TLS2_k127_5115036_8 HpcH/HpaI aldolase/citrate lyase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 320.0
TLS2_k127_5115036_9 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 317.0
TLS2_k127_5118385_0 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 578.0
TLS2_k127_5118385_1 fructose-bisphosphate aldolase K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 521.0
TLS2_k127_5118385_2 Bacterial extracellular solute-binding protein, family 7 K21395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008139 376.0
TLS2_k127_5118385_3 ChrB domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 299.0
TLS2_k127_5118385_4 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000004291 96.0
TLS2_k127_5146993_0 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008033 377.0
TLS2_k127_5146993_1 endonuclease III K03575 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 302.0
TLS2_k127_5146993_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007919 273.0
TLS2_k127_5146993_3 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000005888 205.0
TLS2_k127_5210928_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006211 538.0
TLS2_k127_5210928_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 447.0
TLS2_k127_5210928_2 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 303.0
TLS2_k127_5210928_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 300.0
TLS2_k127_5210928_4 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000000000001827 165.0
TLS2_k127_5210928_5 PFAM YdjC family protein K03478 - 3.5.1.105 0.0000000000000000000000000000000000008833 144.0
TLS2_k127_5210928_6 lactoylglutathione lyase activity - - - 0.0000000000000000000003434 105.0
TLS2_k127_5269206_0 4-hydroxybenzoate K00481 GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0018659,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.14.13.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 601.0
TLS2_k127_5269206_1 COG0665 Glycine D-amino acid oxidases (deaminating) K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 479.0
TLS2_k127_5269206_2 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007062 454.0
TLS2_k127_5269206_3 Peptidase family M28 K02083 - 3.5.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 427.0
TLS2_k127_5269206_4 Protocatechuate 3,4-dioxygenase beta subunit N terminal K00449 - 1.13.11.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 379.0
TLS2_k127_5269206_5 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 377.0
TLS2_k127_5269206_6 Dioxygenase K00448 - 1.13.11.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000831 280.0
TLS2_k127_5269206_7 Belongs to the enoyl-CoA hydratase isomerase family K08299 - 4.2.1.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000002061 258.0
TLS2_k127_5270086_0 Periplasmic binding protein domain K01999 - - 1.474e-213 671.0
TLS2_k127_5270086_1 Involved in the TonB-independent uptake of proteins K03641 - - 9.057e-200 634.0
TLS2_k127_5270086_10 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000008138 147.0
TLS2_k127_5270086_11 periplasmic protein - - - 0.00000000000000000000000000003605 133.0
TLS2_k127_5270086_12 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.0000000000000000000000000744 115.0
TLS2_k127_5270086_13 Protein of unknown function (DUF465) - - - 0.0000000000000005499 79.0
TLS2_k127_5270086_14 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000007588 51.0
TLS2_k127_5270086_15 Cytochrome c - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00002868 55.0
TLS2_k127_5270086_17 periplasmic protein - - - 0.000577 52.0
TLS2_k127_5270086_2 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20940 - 1.14.13.218 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004718 559.0
TLS2_k127_5270086_3 Tripartite ATP-independent periplasmic transporter, DctM component K11690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 505.0
TLS2_k127_5270086_4 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 423.0
TLS2_k127_5270086_5 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 372.0
TLS2_k127_5270086_6 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 345.0
TLS2_k127_5270086_7 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 313.0
TLS2_k127_5270086_8 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000001106 231.0
TLS2_k127_5270086_9 YdjC-like protein K03478 - 3.5.1.105 0.0000000000000000000000000000000000000001667 157.0
TLS2_k127_528749_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 4.959e-226 737.0
TLS2_k127_528749_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 4.826e-209 656.0
TLS2_k127_528749_10 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000002778 207.0
TLS2_k127_528749_2 Belongs to the mandelate racemase muconate lactonizing enzyme family K22209 - 4.2.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 522.0
TLS2_k127_528749_3 Protein of unknown function (DUF3754) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 504.0
TLS2_k127_528749_4 transport system periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 483.0
TLS2_k127_528749_5 Malate/L-lactate dehydrogenase K16844 - 1.1.1.338 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 372.0
TLS2_k127_528749_6 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 321.0
TLS2_k127_528749_7 D-galactarate dehydratase / Altronate hydrolase, C terminus K16846,K16850 - 4.2.1.7,4.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008875 285.0
TLS2_k127_528749_8 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002946 285.0
TLS2_k127_528749_9 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000204 225.0
TLS2_k127_529295_0 Branched-chain amino acid transport system / permease component K01997,K01998 - - 1.501e-220 702.0
TLS2_k127_529295_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 1.142e-196 623.0
TLS2_k127_529295_10 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006656 295.0
TLS2_k127_529295_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006853 288.0
TLS2_k127_529295_12 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003064 272.0
TLS2_k127_529295_13 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001212 260.0
TLS2_k127_529295_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000007909 221.0
TLS2_k127_529295_15 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000003723 148.0
TLS2_k127_529295_17 Putative heavy-metal-binding - - - 0.0000000000000000002075 99.0
TLS2_k127_529295_19 Uncharacterized protein conserved in bacteria (DUF2059) K09924 - - 0.00000000001031 77.0
TLS2_k127_529295_2 monooxygenase - - - 2.02e-196 621.0
TLS2_k127_529295_20 - - - - 0.000000989 55.0
TLS2_k127_529295_21 DnaJ molecular chaperone homology domain - - - 0.000001894 53.0
TLS2_k127_529295_3 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 554.0
TLS2_k127_529295_4 fructose-1,6-bisphosphatase K02446,K11532 - 3.1.3.11,3.1.3.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 499.0
TLS2_k127_529295_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009386 510.0
TLS2_k127_529295_6 carbamoyl transferase, NodU family K00612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008211 409.0
TLS2_k127_529295_7 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 347.0
TLS2_k127_529295_8 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 331.0
TLS2_k127_529295_9 KR domain K00038 - 1.1.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 302.0
TLS2_k127_5313660_0 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 379.0
TLS2_k127_5313660_1 depolymerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 358.0
TLS2_k127_5313660_2 Belongs to the RNase T2 family K01166,K01169 - 3.1.27.1,3.1.27.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 287.0
TLS2_k127_5313660_3 Protein of unknown function (DUF1134) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004889 258.0
TLS2_k127_5313660_4 nuclear chromosome segregation - - - 0.000000000000000000000000000000000000000000000000000000008584 216.0
TLS2_k127_5313660_5 DNA polymerase III, epsilon subunit K02342,K07182 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000002689 207.0
TLS2_k127_5313660_7 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.0000598 46.0
TLS2_k127_5374194_0 nuclear chromosome segregation - - - 3.683e-234 758.0
TLS2_k127_5374194_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 495.0
TLS2_k127_5374194_2 Peptidase S49 K04773,K04774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 375.0
TLS2_k127_5374194_3 Nudix hydrolase - - - 0.000000000000000000000000000000000000000007575 162.0
TLS2_k127_5374194_4 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000000000000000000000000000006946 141.0
TLS2_k127_5374194_5 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000000003715 119.0
TLS2_k127_5374194_6 Uncharacterized ACR, COG1399 - - - 0.00000000000000000000004784 106.0
TLS2_k127_5374194_7 Histidine Phosphotransfer domain - - - 0.0000000000000001218 87.0
TLS2_k127_5422319_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 2.114e-215 677.0
TLS2_k127_5422319_1 Receptor family ligand binding region K01999 - - 3.31e-202 635.0
TLS2_k127_5422319_10 Crp-like helix-turn-helix domain K13642 - - 0.000000000000000000000000000000000000000000000000000000000004292 216.0
TLS2_k127_5422319_11 Flp pilus assembly protein TadC K12511 - - 0.000000000000000000000000000000000000000000000000000001855 205.0
TLS2_k127_5422319_12 Type II secretion system K12510 - - 0.000000000000000000000000000000000000000000000006496 185.0
TLS2_k127_5422319_13 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000002687 114.0
TLS2_k127_5422319_14 - - - - 0.0000000000001147 75.0
TLS2_k127_5422319_15 PFAM peptidase A24A prepilin type IV K02278 - 3.4.23.43 0.00000000000881 75.0
TLS2_k127_5422319_2 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008053 587.0
TLS2_k127_5422319_3 PFAM type II secretion system protein E K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 563.0
TLS2_k127_5422319_4 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 556.0
TLS2_k127_5422319_5 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 507.0
TLS2_k127_5422319_6 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 398.0
TLS2_k127_5422319_7 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 396.0
TLS2_k127_5422319_8 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 298.0
TLS2_k127_5422319_9 AAA domain K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000003625 235.0
TLS2_k127_5479202_0 penicillin-binding protein K05367 - 2.4.1.129 4.095e-267 842.0
TLS2_k127_5479202_1 Polysaccharide deacetylase - - - 4.67e-260 841.0
TLS2_k127_5479202_2 Amidase K01426 - 3.5.1.4 1.165e-225 712.0
TLS2_k127_5479202_3 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006498 464.0
TLS2_k127_5479202_4 carnitine dehydratase K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008271 467.0
TLS2_k127_5479202_5 Protein of unknown function (DUF817) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 323.0
TLS2_k127_5479202_6 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 316.0
TLS2_k127_5479202_7 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 292.0
TLS2_k127_5479202_8 Protein of unknown function (DUF3131) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001001 264.0
TLS2_k127_5479202_9 Inositol monophosphatase family - - - 0.000000000000000000000000000000000000000000000000000000002264 209.0
TLS2_k127_5498080_0 ABC transporter K06158 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 5.702e-277 864.0
TLS2_k127_5498080_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.139e-223 708.0
TLS2_k127_5498080_10 Histidyl-tRNA synthetase K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007521 396.0
TLS2_k127_5498080_11 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 398.0
TLS2_k127_5498080_12 MmgE PrpD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 398.0
TLS2_k127_5498080_13 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 322.0
TLS2_k127_5498080_14 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 300.0
TLS2_k127_5498080_15 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000424 281.0
TLS2_k127_5498080_16 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000632 278.0
TLS2_k127_5498080_17 SURF1 family K14998 GO:0006996,GO:0007005,GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0033108,GO:0033617,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.0000000000000000000000000000000000000000000000000000000000002562 220.0
TLS2_k127_5498080_18 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000008495 207.0
TLS2_k127_5498080_19 Protein of unknown function (DUF983) - - - 0.000000000000000000000000000000000000000000004114 167.0
TLS2_k127_5498080_2 COG1960 Acyl-CoA dehydrogenases K00253 - 1.3.8.4 1.434e-209 661.0
TLS2_k127_5498080_20 Domain of unknown function (DUF4189) - - - 0.00000000000000000000000000002241 135.0
TLS2_k127_5498080_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.417e-195 629.0
TLS2_k127_5498080_4 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 586.0
TLS2_k127_5498080_5 Peptidase M16 inactive domain K07263,K07623 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004571 550.0
TLS2_k127_5498080_6 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 526.0
TLS2_k127_5498080_7 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006027 451.0
TLS2_k127_5498080_8 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 436.0
TLS2_k127_5498080_9 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005822 435.0
TLS2_k127_551989_0 Nitrate reductase beta subunit K00371 - 1.7.5.1 8.807e-200 624.0
TLS2_k127_551989_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004378 490.0
TLS2_k127_551989_10 - - - - 0.00000000000000000000008488 103.0
TLS2_k127_551989_11 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.00000000000003868 83.0
TLS2_k127_551989_12 PFAM Transposase K07491 - - 0.0000003824 52.0
TLS2_k127_551989_2 NnrS protein K07234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000755 428.0
TLS2_k127_551989_3 nitrate reductase, gamma subunit K00374 - 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 385.0
TLS2_k127_551989_4 Nitrate reductase delta subunit K00373 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 308.0
TLS2_k127_551989_5 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 308.0
TLS2_k127_551989_6 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001814 273.0
TLS2_k127_551989_7 - - - - 0.00000000000000000000000000000000000000000000000000000000009795 210.0
TLS2_k127_551989_8 Protein of unknown function (DUF2478) - - - 0.00000000000000000000000000000000000001723 152.0
TLS2_k127_551989_9 Protein of unknown function (DUF454) K09790 - - 0.00000000000000000000000000000000001972 138.0
TLS2_k127_5571415_0 Dehydratase family K01687,K22186 - 4.2.1.82,4.2.1.9 2.269e-313 966.0
TLS2_k127_5571415_1 Proton-conducting membrane transporter - - - 1.222e-275 863.0
TLS2_k127_5571415_2 Proton-conducting membrane transporter K12141 - - 5.115e-244 760.0
TLS2_k127_5571415_3 Luciferase-like monooxygenase - - - 2.707e-234 730.0
TLS2_k127_5571415_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 5.026e-215 685.0
TLS2_k127_5571415_5 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 455.0
TLS2_k127_5571415_6 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 373.0
TLS2_k127_5571415_7 COG4237 Hydrogenase 4 membrane component (E) K12140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 317.0
TLS2_k127_5571415_8 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002192 268.0
TLS2_k127_5571415_9 Universal stress protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001081 261.0
TLS2_k127_5599073_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 3.842e-259 808.0
TLS2_k127_5599073_1 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 496.0
TLS2_k127_5599073_2 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000005012 262.0
TLS2_k127_5599073_3 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000136 246.0
TLS2_k127_5599073_4 Activator of Hsp90 ATPase 1 family protein - - - 0.000000000000000000000003263 102.0
TLS2_k127_5633513_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1345.0
TLS2_k127_5633513_1 glucosyltransferase K03669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 325.0
TLS2_k127_5633513_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000001003 118.0
TLS2_k127_5633513_3 Predicted membrane protein (DUF2306) - - - 0.0000000000000000000002182 98.0
TLS2_k127_5633513_4 Predicted membrane protein (DUF2306) - - - 0.0000000000000001559 79.0
TLS2_k127_5649437_0 5-aminolevulinic acid synthase K00643 - 2.3.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 616.0
TLS2_k127_5649437_1 FAD binding domain K03185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 397.0
TLS2_k127_5649437_2 PFAM MaoC domain protein dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 310.0
TLS2_k127_5649437_3 glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000001449 202.0
TLS2_k127_5649437_4 Conserved hypothetical protein (Lin0512_fam) - - - 0.0000000000000000000000000000009993 129.0
TLS2_k127_5649437_5 Conserved hypothetical protein (Lin0512_fam) - - - 0.0000000000000000000000000006976 121.0
TLS2_k127_5655237_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 2.959e-224 701.0
TLS2_k127_5655237_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 7.485e-219 687.0
TLS2_k127_5655237_10 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 454.0
TLS2_k127_5655237_11 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006520,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016854,GO:0016855,GO:0017144,GO:0018249,GO:0019538,GO:0019752,GO:0019842,GO:0030170,GO:0030378,GO:0030848,GO:0036094,GO:0036211,GO:0036361,GO:0042219,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0047661,GO:0048037,GO:0050662,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 374.0
TLS2_k127_5655237_12 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 368.0
TLS2_k127_5655237_13 Aldo/keto reductase family - GO:0003674,GO:0003824,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 364.0
TLS2_k127_5655237_14 3-beta hydroxysteroid dehydrogenase/isomerase family K18981 - 1.1.1.203 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008043 349.0
TLS2_k127_5655237_15 COG0491 Zn-dependent hydrolases, including glyoxylases - GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 346.0
TLS2_k127_5655237_16 Mitochondrial fission ELM1 K07276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 348.0
TLS2_k127_5655237_17 Nucleoside H+ symporter K05820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 336.0
TLS2_k127_5655237_18 Enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 314.0
TLS2_k127_5655237_19 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002928 302.0
TLS2_k127_5655237_2 Bacterial extracellular solute-binding protein K02027 - - 1.885e-203 642.0
TLS2_k127_5655237_20 Belongs to the Nudix hydrolase family K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001089 289.0
TLS2_k127_5655237_21 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001858 283.0
TLS2_k127_5655237_22 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005165 274.0
TLS2_k127_5655237_23 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000161 263.0
TLS2_k127_5655237_24 COG1985 Pyrimidine reductase, riboflavin biosynthesis K00082 - 1.1.1.193 0.0000000000000000000000000000000000000000000000000000000000000000000000000005712 266.0
TLS2_k127_5655237_25 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002544 267.0
TLS2_k127_5655237_26 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003384 235.0
TLS2_k127_5655237_27 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003014 229.0
TLS2_k127_5655237_28 6-pyruvoyl tetrahydropterin synthase - - - 0.00000000000000000000000000000000000000000000000000000000000005488 216.0
TLS2_k127_5655237_29 helix_turn_helix ASNC type - GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000002361 216.0
TLS2_k127_5655237_3 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 605.0
TLS2_k127_5655237_30 Prokaryotic cytochrome b561 K12262 - - 0.0000000000000000000000000000000000000000000000000000000912 201.0
TLS2_k127_5655237_31 Protein of unknown function (DUF1491) - - - 0.0000000000000000000000000000006979 124.0
TLS2_k127_5655237_32 - - - - 0.0000000000000000000003033 100.0
TLS2_k127_5655237_33 Protein of unknown function (DUF2892) - - - 0.0000000000000000611 81.0
TLS2_k127_5655237_34 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0008513 51.0
TLS2_k127_5655237_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005978 578.0
TLS2_k127_5655237_5 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 554.0
TLS2_k127_5655237_6 Belongs to the ABC transporter superfamily K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006268 548.0
TLS2_k127_5655237_7 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 521.0
TLS2_k127_5655237_8 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000645 486.0
TLS2_k127_5655237_9 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006633 484.0
TLS2_k127_5666447_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 6.722e-230 722.0
TLS2_k127_5666447_1 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001026 265.0
TLS2_k127_5666447_2 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000001459 227.0
TLS2_k127_5666447_3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000000000000000001883 190.0
TLS2_k127_5666447_4 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000000000000000000000000000000000001528 192.0
TLS2_k127_5666447_5 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000005919 169.0
TLS2_k127_5666447_6 Polymer-forming cytoskeletal - - - 0.000000000000002613 80.0
TLS2_k127_5666447_8 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K15738 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - 0.00000000003664 64.0
TLS2_k127_5674426_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 8.872e-278 861.0
TLS2_k127_5674426_1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - 5.014e-230 715.0
TLS2_k127_5674426_10 Dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000001508 205.0
TLS2_k127_5674426_11 glycosyltransferase involved in LPS biosynthesis - - - 0.00000000000000000000000000000000001137 148.0
TLS2_k127_5674426_2 MmgE PrpD family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008523 538.0
TLS2_k127_5674426_3 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 496.0
TLS2_k127_5674426_4 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 478.0
TLS2_k127_5674426_5 drug transmembrane transport K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 459.0
TLS2_k127_5674426_6 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 366.0
TLS2_k127_5674426_7 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 349.0
TLS2_k127_5674426_8 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 304.0
TLS2_k127_5674426_9 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000005621 218.0
TLS2_k127_5708934_0 COG0339 Zn-dependent oligopeptidases K01284 GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.5 1.093e-279 877.0
TLS2_k127_5708934_1 Molecular chaperone. Has ATPase activity K04079 - - 1.217e-245 781.0
TLS2_k127_5708934_10 PAS fold - - - 0.000000000000000000000000000000004404 144.0
TLS2_k127_5708934_11 Thioesterase-like superfamily - - - 0.000000000000000000000002111 108.0
TLS2_k127_5708934_2 HemY protein N-terminus K02498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003464 618.0
TLS2_k127_5708934_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 452.0
TLS2_k127_5708934_4 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 371.0
TLS2_k127_5708934_5 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 344.0
TLS2_k127_5708934_6 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000001017 211.0
TLS2_k127_5708934_7 COG1525 Micrococcal nuclease (thermonuclease) homologs - - - 0.000000000000000000000000000000000000000000000000006012 201.0
TLS2_k127_5708934_8 Protein of unknown function (DUF3750) - - - 0.0000000000000000000000000000000000000000000735 167.0
TLS2_k127_5708934_9 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000008063 163.0
TLS2_k127_5713389_0 Fumarate hydratase K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 2.015e-209 654.0
TLS2_k127_5713389_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 501.0
TLS2_k127_5713389_2 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000001141 255.0
TLS2_k127_5713389_3 - - - - 0.0006046 44.0
TLS2_k127_573181_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 1.329e-235 744.0
TLS2_k127_573181_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 466.0
TLS2_k127_573181_2 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 438.0
TLS2_k127_573181_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 339.0
TLS2_k127_573181_4 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008489 328.0
TLS2_k127_573181_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001893 267.0
TLS2_k127_573181_6 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000003098 231.0
TLS2_k127_573181_7 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000003874 148.0
TLS2_k127_573479_0 Putative serine dehydratase domain K18425 - 4.1.3.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 466.0
TLS2_k127_573479_1 DJ-1/PfpI family K18199 - 4.2.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 323.0
TLS2_k127_573479_2 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 308.0
TLS2_k127_573479_3 ribosomal protein L11 K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005318 261.0
TLS2_k127_573479_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000002577 206.0
TLS2_k127_573479_6 Belongs to the 'phage' integrase family - - - 0.00000000000000000004557 100.0
TLS2_k127_573479_7 - K02221 - - 0.0000000711 58.0
TLS2_k127_5734906_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1778.0
TLS2_k127_5734906_1 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0008150,GO:0008152,GO:0015945,GO:0034308,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:1901615 1.1.1.1,1.1.1.284 7.123e-224 697.0
TLS2_k127_5734906_10 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 505.0
TLS2_k127_5734906_11 Peptidase family M20/M25/M40 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 492.0
TLS2_k127_5734906_12 CoA-transferase family III K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 471.0
TLS2_k127_5734906_13 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 471.0
TLS2_k127_5734906_14 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009468 450.0
TLS2_k127_5734906_15 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 416.0
TLS2_k127_5734906_16 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003236 344.0
TLS2_k127_5734906_17 Nitroreductase K10678 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006182 348.0
TLS2_k127_5734906_18 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009549 346.0
TLS2_k127_5734906_19 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 348.0
TLS2_k127_5734906_2 Amidase - - - 2.606e-214 676.0
TLS2_k127_5734906_20 Belongs to the NiCoT transporter (TC 2.A.52) family K08970 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 324.0
TLS2_k127_5734906_21 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001016 282.0
TLS2_k127_5734906_22 Acetyl-coenzyme A synthetase N-terminus K01895,K01908 GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046950,GO:0046951,GO:0070013,GO:0071704,GO:1901568,GO:1901570,GO:1901576,GO:1902224 6.2.1.1,6.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004819 270.0
TLS2_k127_5734906_23 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003096 258.0
TLS2_k127_5734906_24 C-type lectin (CTL) or carbohydrate-recognition domain (CRD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001045 271.0
TLS2_k127_5734906_25 rRNA binding K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000004812 236.0
TLS2_k127_5734906_26 Invasion associated locus B - - - 0.0000000000000000000000000000000000000000000000000000000000000136 239.0
TLS2_k127_5734906_27 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000007315 196.0
TLS2_k127_5734906_28 HD domain - - - 0.00000000000000000000000000000000000000000000000000002045 196.0
TLS2_k127_5734906_29 PFAM thioesterase superfamily protein K07107 - - 0.00000000000000000000000000000000000000000000000004791 181.0
TLS2_k127_5734906_3 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 612.0
TLS2_k127_5734906_30 Universal stress protein - - - 0.00000000000000000000000000000000000000000000000005135 188.0
TLS2_k127_5734906_31 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000001598 178.0
TLS2_k127_5734906_32 COG3090 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.000000000000000000000000000000000000000000003023 172.0
TLS2_k127_5734906_33 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000002842 159.0
TLS2_k127_5734906_34 Protein of unknown function (DUF1007) - - - 0.000000000000000000000000000000000000000006559 167.0
TLS2_k127_5734906_35 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000002853 169.0
TLS2_k127_5734906_36 Pyroglutamyl peptidase K01304 - 3.4.19.3 0.0000000000000000000000000000000000163 144.0
TLS2_k127_5734906_37 Universal stress protein family - - - 0.00000000000000000000000000000005312 130.0
TLS2_k127_5734906_38 Endoribonuclease L-PSP - - - 0.00000000000000000000000000867 113.0
TLS2_k127_5734906_39 PFAM AIG2 family protein K20757 - 4.3.1.27 0.0000000000000000000008007 100.0
TLS2_k127_5734906_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006842 607.0
TLS2_k127_5734906_42 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00007423 55.0
TLS2_k127_5734906_5 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 600.0
TLS2_k127_5734906_6 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 597.0
TLS2_k127_5734906_7 2-deoxycytidine 5-triphosphate deaminase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 550.0
TLS2_k127_5734906_8 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 520.0
TLS2_k127_5734906_9 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 507.0
TLS2_k127_5743119_0 ATP dependent DNA ligase C terminal region K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 6.462e-258 811.0
TLS2_k127_5743119_1 DNA ligase K01971 - 6.5.1.1 1.02e-239 752.0
TLS2_k127_5743119_10 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005995 406.0
TLS2_k127_5743119_11 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 370.0
TLS2_k127_5743119_12 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 366.0
TLS2_k127_5743119_13 Belongs to the UPF0301 (AlgH) family K07735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003352 248.0
TLS2_k127_5743119_14 Protein tyrosine serine phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000003043 217.0
TLS2_k127_5743119_15 OpgC protein - - - 0.000000000000000000000000000000000000000000000000000000001941 214.0
TLS2_k127_5743119_16 Disulphide bond corrector protein DsbC - - - 0.000000000000000000000000000000000000000000000000000000005946 209.0
TLS2_k127_5743119_17 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000001403 170.0
TLS2_k127_5743119_18 - - - - 0.000000000000000000000000000000000000000003106 170.0
TLS2_k127_5743119_19 response regulator K07782,K15852,K18304,K19731,K19733 - - 0.0000000000000000000000000000000000000006801 160.0
TLS2_k127_5743119_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 2.786e-204 663.0
TLS2_k127_5743119_20 Belongs to the UPF0337 (CsbD) family - - - 0.00000000000000000000000000000004979 125.0
TLS2_k127_5743119_22 Recombinase zinc beta ribbon domain - - - 0.000001204 59.0
TLS2_k127_5743119_23 phage tail tape measure protein - - - 0.0002014 53.0
TLS2_k127_5743119_3 His Kinase A (phospho-acceptor) domain K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 529.0
TLS2_k127_5743119_4 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 503.0
TLS2_k127_5743119_5 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 429.0
TLS2_k127_5743119_6 Domain of unknown function (DUF374) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 428.0
TLS2_k127_5743119_7 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009681 421.0
TLS2_k127_5743119_8 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 411.0
TLS2_k127_5743119_9 Sigma-54 interaction domain K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 392.0
TLS2_k127_5743463_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1412.0
TLS2_k127_5743463_1 Helicase K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.0 1043.0
TLS2_k127_5743463_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 9.562e-239 745.0
TLS2_k127_5743463_3 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 463.0
TLS2_k127_5743463_4 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 454.0
TLS2_k127_5743463_5 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 428.0
TLS2_k127_5743463_6 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 313.0
TLS2_k127_5743463_7 ATP12 chaperone protein - - - 0.000000000000000000000000000000000000000000000002759 178.0
TLS2_k127_5743463_8 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000000000006313 98.0
TLS2_k127_5743463_9 Protein of unknown function (DUF1674) - - - 0.0000000000001016 75.0
TLS2_k127_5770883_0 AcrB/AcrD/AcrF family - - - 3.884e-311 979.0
TLS2_k127_5770883_1 Glycosyl hydrolases family 15 - - - 7.341e-262 819.0
TLS2_k127_5770883_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 312.0
TLS2_k127_5770883_11 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008974 301.0
TLS2_k127_5770883_12 Barrel-sandwich domain of CusB or HlyD membrane-fusion K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001314 256.0
TLS2_k127_5770883_13 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000001645 235.0
TLS2_k127_5770883_14 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000001479 231.0
TLS2_k127_5770883_15 Acetyl xylan esterase (AXE1) K06889,K07397 - - 0.000000000000000000000000000000000000000000000000000000004437 209.0
TLS2_k127_5770883_16 nuclear export factor GLE1 K09796 - - 0.00000000000000000000000000000000000000000000006058 176.0
TLS2_k127_5770883_17 peroxiredoxin activity K01607 - 4.1.1.44 0.000000000000000000000000000000000000000487 152.0
TLS2_k127_5770883_18 Pfam Small Multidrug Resistance protein K11741 - - 0.0000000000000000000000000000000000000005352 151.0
TLS2_k127_5770883_19 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000002288 130.0
TLS2_k127_5770883_2 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007257 606.0
TLS2_k127_5770883_20 AntiSigma factor - - - 0.0000000000000000000002408 106.0
TLS2_k127_5770883_21 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.00000000000000006792 84.0
TLS2_k127_5770883_3 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 575.0
TLS2_k127_5770883_4 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 540.0
TLS2_k127_5770883_5 COG0076 Glutamate decarboxylase and related PLP-dependent proteins K01634 - 4.1.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 525.0
TLS2_k127_5770883_6 pfkB family carbohydrate kinase K00852 - 2.7.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003559 402.0
TLS2_k127_5770883_7 Histone deacetylase domain K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 379.0
TLS2_k127_5770883_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 365.0
TLS2_k127_5770883_9 Luciferase-like monooxygenase K14733 - 1.14.13.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 342.0
TLS2_k127_5782906_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 9.02e-307 957.0
TLS2_k127_5782906_1 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 5.031e-205 646.0
TLS2_k127_5782906_2 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 388.0
TLS2_k127_5782906_3 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 381.0
TLS2_k127_5782906_4 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003624 269.0
TLS2_k127_5782906_5 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000001695 242.0
TLS2_k127_5782906_6 - - - - 0.000000000000000000000000000000000000000000000000000006237 204.0
TLS2_k127_5782906_7 Protein conserved in bacteria K09937 - - 0.000000000003464 70.0
TLS2_k127_5786840_0 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 323.0
TLS2_k127_5786840_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001433 279.0
TLS2_k127_5786840_2 ABC transporter K02049 - - 0.0000000000000000000000000000000000001776 156.0
TLS2_k127_5786840_3 Protein of unknown function (DUF992) - - - 0.0000000002246 68.0
TLS2_k127_5796337_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0 1074.0
TLS2_k127_5796337_1 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 3.93e-207 670.0
TLS2_k127_5796337_11 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000817 54.0
TLS2_k127_5796337_2 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 552.0
TLS2_k127_5796337_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 385.0
TLS2_k127_5796337_4 DnaJ C terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003929 375.0
TLS2_k127_5796337_5 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 381.0
TLS2_k127_5796337_6 AI-2E family transporter K03548 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006555 349.0
TLS2_k127_5796337_7 SurA N-terminal domain K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 322.0
TLS2_k127_5796337_8 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000001355 235.0
TLS2_k127_5796337_9 Belongs to the DnaA family - - - 0.00000000000000000000000000000000000000000000000000000001334 220.0
TLS2_k127_581460_0 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 3.268e-295 934.0
TLS2_k127_581460_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 6.116e-215 673.0
TLS2_k127_581460_10 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003337 262.0
TLS2_k127_581460_11 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000006426 242.0
TLS2_k127_581460_12 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000001322 179.0
TLS2_k127_581460_13 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000001698 179.0
TLS2_k127_581460_14 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000005274 132.0
TLS2_k127_581460_2 malonyl CoA-acyl carrier protein transacylase K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 464.0
TLS2_k127_581460_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003523 423.0
TLS2_k127_581460_4 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 408.0
TLS2_k127_581460_5 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 410.0
TLS2_k127_581460_6 PFAM short-chain dehydrogenase reductase SDR K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009719 370.0
TLS2_k127_581460_7 Protein of unknown function DUF262 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 316.0
TLS2_k127_581460_8 Nucleotidyl transferase K00966,K00992 - 2.7.7.13,2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 302.0
TLS2_k127_581460_9 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 287.0
TLS2_k127_5824390_0 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000775 480.0
TLS2_k127_5824390_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 342.0
TLS2_k127_5824390_2 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 314.0
TLS2_k127_5824390_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000002692 162.0
TLS2_k127_5824390_4 Glycosyltransferase like family 2 - - - 0.00000000000000000000005909 100.0
TLS2_k127_5848984_0 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 563.0
TLS2_k127_5848984_1 Glucose / Sorbosone dehydrogenase K00117,K21430 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 1.1.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 458.0
TLS2_k127_5848984_10 Peptidase M15 - - - 0.000000000003483 73.0
TLS2_k127_5848984_2 NMT1-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005587 443.0
TLS2_k127_5848984_3 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 397.0
TLS2_k127_5848984_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 368.0
TLS2_k127_5848984_5 Colicin V production protein K03558 - - 0.00000000000000000000000000000000000000000000000000000000000000005562 226.0
TLS2_k127_5848984_6 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000002768 180.0
TLS2_k127_5848984_7 PFAM KDPG and KHG aldolase K01625 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000001149 180.0
TLS2_k127_5848984_8 Universal stress protein family - - - 0.00000000000000000000000000000000000000000006937 172.0
TLS2_k127_5848984_9 N-terminal domain of oxidoreductase K07119 - - 0.000000000000000000000004433 103.0
TLS2_k127_5877127_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 9.217e-196 626.0
TLS2_k127_5877127_1 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 518.0
TLS2_k127_5877127_2 Radical SAM K09711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 508.0
TLS2_k127_5877127_3 MmgE/PrpD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000707 472.0
TLS2_k127_5877127_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002353 276.0
TLS2_k127_5877127_5 MarR family - - - 0.00000000000000000000000000000000000000000000000000000000000004556 218.0
TLS2_k127_5877127_6 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000006131 209.0
TLS2_k127_5877127_7 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000004307 209.0
TLS2_k127_5877127_8 Endoribonuclease L-PSP - - - 0.00000000000000000000000000006779 122.0
TLS2_k127_5882219_0 Cellulose synthase K00694 - 2.4.1.12 3.32e-228 723.0
TLS2_k127_5882219_1 ATP synthase alpha/beta family, nucleotide-binding domain K02412 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0009288,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0042995,GO:0043226,GO:0043228,GO:0044464 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 493.0
TLS2_k127_5882219_10 Protein of unknown function (DUF1217) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004841 284.0
TLS2_k127_5882219_11 Belongs to the flagella basal body rod proteins family K02391,K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000502 256.0
TLS2_k127_5882219_12 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000001103 223.0
TLS2_k127_5882219_13 Membrane MotB of proton-channel complex MotA/MotB K02557 - - 0.000000000000000000000000000000000000000000000000001092 203.0
TLS2_k127_5882219_14 Belongs to the flagella basal body rod proteins family K02388 GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - 0.0000000000000000000000000000000000000000000002102 170.0
TLS2_k127_5882219_15 in Rhizobium, interactions between MotB and MotC at the periplasmic surface of the motor control the energy flux or the energy coupling that drives flagellar rotation K10564 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000000000000000000000000000001431 169.0
TLS2_k127_5882219_16 Flagella basal body rod protein K02387 - - 0.000000000000000000000000004534 117.0
TLS2_k127_5882219_17 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.0000000000000000000000001083 113.0
TLS2_k127_5882219_18 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000002111 108.0
TLS2_k127_5882219_19 PFAM MgtE intracellular - - - 0.00000000000000000000005722 106.0
TLS2_k127_5882219_2 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 428.0
TLS2_k127_5882219_20 Transcriptional regulator GntR family K03710 - - 0.00000000000000000000256 103.0
TLS2_k127_5882219_21 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243 - 0.00000000000000000002384 98.0
TLS2_k127_5882219_22 - - - - 0.00000000000000000459 91.0
TLS2_k127_5882219_23 Flagellar hook-basal body complex protein FliE K02408 GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - 0.000000000000000009336 88.0
TLS2_k127_5882219_24 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.0000000000007706 76.0
TLS2_k127_5882219_3 The M ring may be actively involved in energy transduction K02409 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 423.0
TLS2_k127_5882219_4 MotA/TolQ/ExbB proton channel family K02556 GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 402.0
TLS2_k127_5882219_5 Flagella basal body rod protein K02392 GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009876 347.0
TLS2_k127_5882219_6 Plays a role in the flagellum-specific transport system K02419 GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 323.0
TLS2_k127_5882219_7 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 321.0
TLS2_k127_5882219_8 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 319.0
TLS2_k127_5882219_9 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008298 301.0
TLS2_k127_5896373_0 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 0.0 1035.0
TLS2_k127_5896373_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 407.0
TLS2_k127_5896373_2 - - - - 0.0000000000000000000000000000000004169 136.0
TLS2_k127_5896373_3 Histidine kinase K13587 - 2.7.13.3 0.00000000000000001964 82.0
TLS2_k127_5898503_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812,K08351 - 1.7.2.3 6.779e-290 905.0
TLS2_k127_5898503_1 Disulphide bond corrector protein DsbC K04084 - 1.8.1.8 2.385e-283 888.0
TLS2_k127_5898503_2 ABC transporter K06147,K18893 - - 7.906e-273 851.0
TLS2_k127_5898503_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006777 600.0
TLS2_k127_5898503_4 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 452.0
TLS2_k127_5898503_5 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001958 259.0
TLS2_k127_5898503_6 Protein of unknown function (DUF3500) - - - 0.0000000000000000000000000000000000000000000000000000000008905 215.0
TLS2_k127_5898503_7 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000379 188.0
TLS2_k127_5898503_8 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000002172 157.0
TLS2_k127_5927963_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 526.0
TLS2_k127_5927963_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 434.0
TLS2_k127_5927963_2 Cupin domain - - - 0.000000000000000000008206 101.0
TLS2_k127_5927963_4 Sulfatase - - - 0.000000001694 61.0
TLS2_k127_5930385_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 4.873e-256 799.0
TLS2_k127_5930385_1 TRAP transporter, 4TM 12TM fusion protein - - - 7.909e-221 703.0
TLS2_k127_5930385_2 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 618.0
TLS2_k127_5930385_3 transport system periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 358.0
TLS2_k127_5930385_4 PFAM UspA domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000245 247.0
TLS2_k127_5930385_5 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000002262 201.0
TLS2_k127_5930385_6 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000006277 172.0
TLS2_k127_5932204_0 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 468.0
TLS2_k127_5932204_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 437.0
TLS2_k127_5932204_11 Belongs to the CinA family - - - 0.0000000000000000000000000000000000000000000000000000000003262 207.0
TLS2_k127_5932204_12 Staphylococcal nuclease homologue - - - 0.000000000000000000000000000000000000000000001046 175.0
TLS2_k127_5932204_2 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 437.0
TLS2_k127_5932204_3 PFAM Mg2 transporter protein CorA family protein K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 415.0
TLS2_k127_5932204_4 MoeA C-terminal region (domain IV) K03750 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 396.0
TLS2_k127_5932204_5 indole-3-glycerol-phosphate synthase activity K01609,K13498 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 383.0
TLS2_k127_5932204_6 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 327.0
TLS2_k127_5932204_7 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 317.0
TLS2_k127_5932204_8 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 308.0
TLS2_k127_5932204_9 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000004135 242.0
TLS2_k127_5938010_0 Diguanylate cyclase - - - 4.524e-194 623.0
TLS2_k127_5938010_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 387.0
TLS2_k127_5938010_2 Ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 317.0
TLS2_k127_5938010_3 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000002505 201.0
TLS2_k127_5938010_4 - - - - 0.000000000000000000000000000000000000000003043 162.0
TLS2_k127_5938010_5 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000001819 89.0
TLS2_k127_5948404_0 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 5.751e-294 915.0
TLS2_k127_5948404_1 AMP-binding enzyme C-terminal domain K00666,K02182,K20034 - 6.2.1.44,6.2.1.48 3.938e-222 700.0
TLS2_k127_5948404_10 Inner membrane component of T3SS, cytoplasmic domain K01768 - 4.6.1.1 0.0000000000000007388 87.0
TLS2_k127_5948404_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 2.194e-208 651.0
TLS2_k127_5948404_3 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate K07516 - 1.1.1.35 1.788e-206 664.0
TLS2_k127_5948404_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 522.0
TLS2_k127_5948404_5 branched-chain amino acid K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004624 441.0
TLS2_k127_5948404_6 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000001632 259.0
TLS2_k127_5948404_7 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000305 250.0
TLS2_k127_5948404_8 COG1716 FOG FHA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001117 229.0
TLS2_k127_5948404_9 Periplasmic binding protein K01999 - - 0.000000000000000000000000000003315 120.0
TLS2_k127_6013654_0 Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA K01638 - 2.3.3.9 5.901e-303 944.0
TLS2_k127_6013654_1 AMP-binding enzyme K01897 - 6.2.1.3 1.006e-296 920.0
TLS2_k127_6013654_10 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005323 255.0
TLS2_k127_6013654_11 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000001967 205.0
TLS2_k127_6013654_12 - - - - 0.00000000000000000000000000000000000000000001033 169.0
TLS2_k127_6013654_13 PFAM lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000002857 172.0
TLS2_k127_6013654_15 Major Facilitator Superfamily - - - 0.0000000001753 64.0
TLS2_k127_6013654_16 AsmA-like C-terminal region K07289 - - 0.00000008961 65.0
TLS2_k127_6013654_2 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 2.265e-275 861.0
TLS2_k127_6013654_3 Receptor family ligand binding region - - - 5.381e-206 646.0
TLS2_k127_6013654_4 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 8.715e-205 642.0
TLS2_k127_6013654_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 580.0
TLS2_k127_6013654_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 464.0
TLS2_k127_6013654_7 ErfK YbiS YcfS YnhG family protein K21470,K21572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008207 457.0
TLS2_k127_6013654_8 branched-chain amino acid transport K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 444.0
TLS2_k127_6013654_9 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 426.0
TLS2_k127_6032608_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 527.0
TLS2_k127_6032608_1 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 435.0
TLS2_k127_6032608_10 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000004683 183.0
TLS2_k127_6032608_11 Protein of unknown function (DUF2853) - - - 0.00000000000000000000000000000000009524 138.0
TLS2_k127_6032608_12 Transcriptional regulator, Crp Fnr family - - - 0.000000000000000000000000000000002174 136.0
TLS2_k127_6032608_13 Diguanylate cyclase - - - 0.00000003876 55.0
TLS2_k127_6032608_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 376.0
TLS2_k127_6032608_3 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 357.0
TLS2_k127_6032608_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 332.0
TLS2_k127_6032608_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001019 285.0
TLS2_k127_6032608_6 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001803 244.0
TLS2_k127_6032608_7 Uncharacterised protein family (UPF0093) K08973 - - 0.000000000000000000000000000000000000000000000000000000000000000001106 231.0
TLS2_k127_6032608_8 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000003235 208.0
TLS2_k127_6032608_9 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000000000000000000000000000000000000000000000000001096 195.0
TLS2_k127_6118597_0 type VI secretion protein K11900 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006396 253.0
TLS2_k127_6118597_1 Type VI secretion system effector K06887,K11903 - - 0.00000000000000000000000000000000000000000000001374 175.0
TLS2_k127_6118597_2 Psort location Cytoplasmic, score 8.96 - - - 0.0007044 46.0
TLS2_k127_6192246_0 belongs to the aldehyde dehydrogenase family - - - 5.099e-263 815.0
TLS2_k127_6192246_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 3.844e-247 769.0
TLS2_k127_6192246_10 Zinc-dependent metalloprotease - - - 0.00000000000000000000000000000000000000000000000000003016 195.0
TLS2_k127_6192246_11 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000001389 147.0
TLS2_k127_6192246_12 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000005004 89.0
TLS2_k127_6192246_13 Type I phosphodiesterase / nucleotide pyrophosphatase K19670 - 3.11.1.2 0.00000000000001214 74.0
TLS2_k127_6192246_2 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 2.787e-194 625.0
TLS2_k127_6192246_3 Na+/Pi-cotransporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005878 583.0
TLS2_k127_6192246_4 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 572.0
TLS2_k127_6192246_5 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 555.0
TLS2_k127_6192246_6 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 471.0
TLS2_k127_6192246_7 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 447.0
TLS2_k127_6192246_8 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 321.0
TLS2_k127_6192246_9 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.00000000000000000000000000000000000000000000000000000000000000001145 229.0
TLS2_k127_6232106_0 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 5.416e-261 808.0
TLS2_k127_6232106_1 4Fe-4S dicluster domain K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 466.0
TLS2_k127_6232106_2 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000001514 222.0
TLS2_k127_6232106_3 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000004086 191.0
TLS2_k127_6232106_4 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000001867 164.0
TLS2_k127_6232106_5 FAD dependent oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000003316 67.0
TLS2_k127_6301390_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 6.269e-240 751.0
TLS2_k127_6301390_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 2.131e-235 731.0
TLS2_k127_6301390_10 Domain of unknown function (DUF1476) - - - 0.0000000000000000000000000000000000004834 142.0
TLS2_k127_6301390_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 567.0
TLS2_k127_6301390_3 acetylornithine K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007693 548.0
TLS2_k127_6301390_4 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009237 478.0
TLS2_k127_6301390_5 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 449.0
TLS2_k127_6301390_6 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 367.0
TLS2_k127_6301390_7 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000911 310.0
TLS2_k127_6301390_8 Alpha beta hydrolase K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 306.0
TLS2_k127_6301390_9 Bacterial SH3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003815 255.0
TLS2_k127_637149_0 ATP-dependent DNA helicase RecQ K03654 GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 9.067e-244 774.0
TLS2_k127_637149_1 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 6.193e-205 646.0
TLS2_k127_637149_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001425 233.0
TLS2_k127_637149_11 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000000000000000002124 219.0
TLS2_k127_637149_12 FR47-like protein K03789 - 2.3.1.128 0.000000000000000000000000000000000000004332 153.0
TLS2_k127_637149_13 Glycoprotease family K01409,K14742 - 2.3.1.234 0.00000000000000000000000000000000001466 144.0
TLS2_k127_637149_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 585.0
TLS2_k127_637149_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 539.0
TLS2_k127_637149_4 carbohydrate kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004449 465.0
TLS2_k127_637149_5 membrane-associated protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 299.0
TLS2_k127_637149_6 NIPSNAP - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 300.0
TLS2_k127_637149_7 Bacterial transcriptional repressor C-terminal K16137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000432 287.0
TLS2_k127_637149_8 Scaffold protein Nfu NifU - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002691 275.0
TLS2_k127_637149_9 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001949 262.0
TLS2_k127_6414326_0 E1 component K00164 - 1.2.4.2 0.0 1566.0
TLS2_k127_6414326_1 Belongs to the ClpA ClpB family K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.0 1204.0
TLS2_k127_6414326_10 luciferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 336.0
TLS2_k127_6414326_11 HIT family hydrolase K02503 - - 0.000000000000000000000000000000000000000000000000000000001654 203.0
TLS2_k127_6414326_12 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000000000000000000000001605 199.0
TLS2_k127_6414326_13 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000001348 187.0
TLS2_k127_6414326_14 - - - - 0.0000000000000000000000000000000000000000000000001776 191.0
TLS2_k127_6414326_15 AzlC protein - - - 0.000000000000000000000000000000000000000000005377 172.0
TLS2_k127_6414326_16 - - - - 0.00000000000000000000000000007805 124.0
TLS2_k127_6414326_17 Branched-chain amino acid transport - - - 0.000000000000000000001229 99.0
TLS2_k127_6414326_18 Protein of unknown function (DUF1192) - - - 0.0000000000002376 73.0
TLS2_k127_6414326_2 Flavin containing amine oxidoreductase - - - 4.858e-254 792.0
TLS2_k127_6414326_3 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 6.658e-230 725.0
TLS2_k127_6414326_4 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 6.206e-222 695.0
TLS2_k127_6414326_5 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 571.0
TLS2_k127_6414326_6 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006844 493.0
TLS2_k127_6414326_7 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 434.0
TLS2_k127_6414326_8 PFAM D-isomer specific 2-hydroxyacid dehydrogenase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009606 371.0
TLS2_k127_6414326_9 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K16165 - 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 361.0
TLS2_k127_6415429_0 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004081 346.0
TLS2_k127_6415429_1 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 335.0
TLS2_k127_6415429_2 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007063 248.0
TLS2_k127_6415429_3 Glycine cleavage H-protein K02437 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002492 240.0
TLS2_k127_6415429_4 - - - - 0.00000000000000000000000000000000000000000000001214 179.0
TLS2_k127_6415429_5 Protein conserved in bacteria K09948 - - 0.00000000000000000000000000000000000000000002078 162.0
TLS2_k127_6415429_6 GDP-mannose mannosyl hydrolase activity K00077,K01092,K03574 - 1.1.1.169,3.1.3.25,3.6.1.55 0.0000000000000000000000000001572 123.0
TLS2_k127_6415429_7 Tellurite resistance protein TehB - - - 0.00000000000003972 74.0
TLS2_k127_6465173_0 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 2.538e-203 640.0
TLS2_k127_6465173_1 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 441.0
TLS2_k127_6465173_2 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 423.0
TLS2_k127_6465173_3 Belongs to the peptidase S11 family K01286 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 362.0
TLS2_k127_6465173_4 L-proline glycine betaine ABC transport system permease protein ProW K02001,K02002 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 355.0
TLS2_k127_6465173_5 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000000000000000000001009 163.0
TLS2_k127_6572436_0 Amidohydrolase K07045 - - 1.909e-277 859.0
TLS2_k127_6572436_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 1.25e-231 726.0
TLS2_k127_6572436_10 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 374.0
TLS2_k127_6572436_11 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 342.0
TLS2_k127_6572436_12 Enoyl-CoA hydratase/isomerase K01692,K05605 - 3.1.2.4,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 333.0
TLS2_k127_6572436_13 WHG domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002358 282.0
TLS2_k127_6572436_14 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006171 263.0
TLS2_k127_6572436_15 NADPH-quinone reductase (modulator of drug activity B) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003273 256.0
TLS2_k127_6572436_17 Extensin-like protein C-terminus - - - 0.000000000000000000000000000000000000000000000000000000002736 217.0
TLS2_k127_6572436_18 Lipopolysaccharide-assembly K03643 - - 0.000000000000000000000000000000000000000000001629 170.0
TLS2_k127_6572436_19 Anion-transporting ATPase K03496 - - 0.000000000000000000000000000000000000000000004323 179.0
TLS2_k127_6572436_2 Binding-protein-dependent transport system inner membrane component K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007349 592.0
TLS2_k127_6572436_20 Protein of unknown function (DUF2852) - - - 0.000000000000000000000000000000000000009896 150.0
TLS2_k127_6572436_21 Phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000000000000004478 132.0
TLS2_k127_6572436_3 Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 541.0
TLS2_k127_6572436_4 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004676 499.0
TLS2_k127_6572436_5 COG0226 ABC-type phosphate transport system, periplasmic component K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 480.0
TLS2_k127_6572436_6 Pantothenic acid kinase K00867 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 476.0
TLS2_k127_6572436_7 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005938 433.0
TLS2_k127_6572436_8 Benzoate membrane transport protein K05782 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 428.0
TLS2_k127_6572436_9 pfkB family carbohydrate kinase K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 383.0
TLS2_k127_6575913_0 Hydantoinase/oxoprolinase - - - 2.78e-312 969.0
TLS2_k127_6575913_1 Hydantoinase B/oxoprolinase - - - 6.335e-294 909.0
TLS2_k127_6575913_10 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005215 271.0
TLS2_k127_6575913_11 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000003788 215.0
TLS2_k127_6575913_12 Histidine kinase K13587 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000009442 210.0
TLS2_k127_6575913_13 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000001815 175.0
TLS2_k127_6575913_14 Flagellar biosynthesis protein, FliO - - - 0.0000000000000000000000003394 111.0
TLS2_k127_6575913_15 COG0790 FOG TPR repeat, SEL1 subfamily - - - 0.000000000002999 79.0
TLS2_k127_6575913_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.357e-219 693.0
TLS2_k127_6575913_3 Aminotransferase class I and II K14155 - 4.4.1.8 5.039e-201 636.0
TLS2_k127_6575913_4 Mechanosensitive ion channel K05802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 598.0
TLS2_k127_6575913_5 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 429.0
TLS2_k127_6575913_6 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 408.0
TLS2_k127_6575913_7 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 402.0
TLS2_k127_6575913_8 KR domain K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 358.0
TLS2_k127_6575913_9 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008482 346.0
TLS2_k127_6582317_0 Belongs to the TPP enzyme family K01576 - 4.1.1.7 1.548e-255 798.0
TLS2_k127_6582317_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 578.0
TLS2_k127_6582317_2 Zinc-binding dehydrogenase K00001,K00055 - 1.1.1.1,1.1.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 441.0
TLS2_k127_6582317_3 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000913 401.0
TLS2_k127_6582317_4 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 372.0
TLS2_k127_6582317_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 337.0
TLS2_k127_6582317_6 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 329.0
TLS2_k127_6582317_7 Domain of unknown function (DUF4170) - - - 0.000000000000000000000000000002064 123.0
TLS2_k127_6582317_8 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179,K06125 - 2.5.1.39 0.0000000000000003206 80.0
TLS2_k127_6582317_9 Protein of unknown function (DUF2842) - - - 0.00000002373 60.0
TLS2_k127_6583658_0 Carboxyl transferase domain K01969 - 6.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 443.0
TLS2_k127_6583658_1 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005168 426.0
TLS2_k127_6583658_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 419.0
TLS2_k127_6583658_3 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 355.0
TLS2_k127_6583658_4 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000006316 233.0
TLS2_k127_6587850_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - 0.0 1225.0
TLS2_k127_6587850_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 1.592e-278 865.0
TLS2_k127_6587850_10 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 324.0
TLS2_k127_6587850_11 Carboxylesterase family K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 328.0
TLS2_k127_6587850_12 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 331.0
TLS2_k127_6587850_13 Belongs to the bacterial solute-binding protein 3 family K09969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 310.0
TLS2_k127_6587850_14 This stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007289 268.0
TLS2_k127_6587850_15 Dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001881 269.0
TLS2_k127_6587850_16 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000005811 246.0
TLS2_k127_6587850_17 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000004472 239.0
TLS2_k127_6587850_18 Domain of unknown function (DUF1849) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008666 248.0
TLS2_k127_6587850_19 Nudix hydrolase K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000001183 229.0
TLS2_k127_6587850_2 H( )-stimulated, divalent metal cation uptake system K03322 - - 1.762e-223 701.0
TLS2_k127_6587850_20 Domain of unknown function (DUF1932) - - - 0.000000000000000000000000000000000000000000000000000000000000000001656 237.0
TLS2_k127_6587850_21 EVE domain - - - 0.0000000000000000000000000000000000000000000000000000000000001032 220.0
TLS2_k127_6587850_22 PFAM NIPSNAP family containing protein - - - 0.0000000000000000000000000000000000000000000000000000002475 198.0
TLS2_k127_6587850_23 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000002032 192.0
TLS2_k127_6587850_24 PFAM Xylose isomerase - - - 0.000000000000000000000000000000000000000000000001167 185.0
TLS2_k127_6587850_25 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000000002351 175.0
TLS2_k127_6587850_26 Two component transcriptional regulator PhoB, winged helix family K07657 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000004876 171.0
TLS2_k127_6587850_27 Clp amino terminal domain, pathogenicity island component - - - 0.00000000000000000000000000000000000000000001922 177.0
TLS2_k127_6587850_28 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000000000000000000000001159 154.0
TLS2_k127_6587850_29 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000002449 125.0
TLS2_k127_6587850_3 unusual protein kinase - - - 2.184e-206 651.0
TLS2_k127_6587850_30 Belongs to the BolA IbaG family - - - 0.0000000000000000000000000000006324 123.0
TLS2_k127_6587850_31 Protein of unknown function (DUF2865) - - - 0.00000000000000000000000000005291 128.0
TLS2_k127_6587850_32 Tellurite resistance protein TerB - - - 0.0000000000000000000000002609 111.0
TLS2_k127_6587850_33 - - - - 0.0000000000000000000004486 99.0
TLS2_k127_6587850_4 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005604 559.0
TLS2_k127_6587850_5 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 495.0
TLS2_k127_6587850_6 Protein of unknown function (DUF815) K06923 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 428.0
TLS2_k127_6587850_7 paraquat-inducible protein A K03808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 404.0
TLS2_k127_6587850_8 NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 384.0
TLS2_k127_6587850_9 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 349.0
TLS2_k127_6604416_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 1.544e-242 753.0
TLS2_k127_6604416_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 2.185e-221 698.0
TLS2_k127_6604416_10 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001028 252.0
TLS2_k127_6604416_11 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000000000000004064 146.0
TLS2_k127_6604416_12 - - - - 0.000000000000000000000000000000001441 134.0
TLS2_k127_6604416_13 Squalene/phytoene synthase K02291,K18163 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000003373 128.0
TLS2_k127_6604416_14 Preprotein translocase subunit K03210 - - 0.00000000000000000000000000005203 122.0
TLS2_k127_6604416_15 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000000000000003091 117.0
TLS2_k127_6604416_16 Urate oxidase N-terminal - - - 0.0000000000000000005895 94.0
TLS2_k127_6604416_2 PFAM Prokaryotic protein of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007026 542.0
TLS2_k127_6604416_3 Psort location Cytoplasmic, score 7.50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 502.0
TLS2_k127_6604416_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 402.0
TLS2_k127_6604416_5 NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 365.0
TLS2_k127_6604416_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 297.0
TLS2_k127_6604416_7 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001579 279.0
TLS2_k127_6604416_8 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003475 286.0
TLS2_k127_6604416_9 Polycystin cation channel K08714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000115 272.0
TLS2_k127_6617999_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1274.0
TLS2_k127_6617999_1 Iron-containing alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 499.0
TLS2_k127_6617999_2 Type I phosphodiesterase / nucleotide pyrophosphatase K19670 - 3.11.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008432 469.0
TLS2_k127_6617999_3 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 355.0
TLS2_k127_6621463_0 Acyl-CoA reductase (LuxC) K00140 GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896 1.2.1.18,1.2.1.27 8.252e-275 852.0
TLS2_k127_6621463_1 Alanine dehydrogenase/PNT, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 561.0
TLS2_k127_6621463_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 403.0
TLS2_k127_6621463_3 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 341.0
TLS2_k127_6621463_4 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007173 308.0
TLS2_k127_6621463_5 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000005491 160.0
TLS2_k127_6621463_6 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00018,K00058 - 1.1.1.29,1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000001007 151.0
TLS2_k127_6621463_7 - - - - 0.0000000000000000000008665 100.0
TLS2_k127_6633752_0 Uncharacterized protein family (UPF0051) K09014 - - 3.493e-275 854.0
TLS2_k127_6633752_1 IMP dehydrogenase / GMP reductase domain K22083 - 2.1.1.21 1.874e-244 766.0
TLS2_k127_6633752_10 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000001131 196.0
TLS2_k127_6633752_11 FeS assembly SUF system protein - - - 0.000000000000000000000000000000000000000000000000001356 186.0
TLS2_k127_6633752_12 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000463 186.0
TLS2_k127_6633752_13 Transcriptional regulator K13643 - - 0.000000000000000000000000000000000000000006485 159.0
TLS2_k127_6633752_14 Putative phosphatase (DUF442) - - - 0.00000000004492 69.0
TLS2_k127_6633752_15 Cell division protein K09811 - - 0.00000886 48.0
TLS2_k127_6633752_2 Glutamine synthetase, catalytic domain K01915,K01949 - 6.3.1.2,6.3.4.12 1.386e-208 657.0
TLS2_k127_6633752_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007557 594.0
TLS2_k127_6633752_4 FeS assembly protein SufD K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 452.0
TLS2_k127_6633752_5 FeS assembly ATPase SufC K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 417.0
TLS2_k127_6633752_6 Aminotransferase class-V K04487 GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 392.0
TLS2_k127_6633752_7 X-Pro dipeptidyl-peptidase (S15 family) K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 363.0
TLS2_k127_6633752_8 MOSC N-terminal beta barrel domain K07140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 308.0
TLS2_k127_6633752_9 GXGXG motif K22082 - 2.1.1.21 0.00000000000000000000000000000000000000000000000000000009271 196.0
TLS2_k127_6641857_0 COG1653 ABC-type sugar transport system, periplasmic component K17321 - - 5.664e-310 956.0
TLS2_k127_6641857_1 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 9.431e-199 631.0
TLS2_k127_6641857_10 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000005118 239.0
TLS2_k127_6641857_11 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.0000000000000000000000000000000001291 132.0
TLS2_k127_6641857_12 Small integral membrane protein - - - 0.0000000000000000000000000000000004805 133.0
TLS2_k127_6641857_2 Belongs to the ABC transporter superfamily K17325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 499.0
TLS2_k127_6641857_3 COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 500.0
TLS2_k127_6641857_4 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 505.0
TLS2_k127_6641857_5 Binding-protein-dependent transport system inner membrane component K17323 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 462.0
TLS2_k127_6641857_6 TOBE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 468.0
TLS2_k127_6641857_7 COG1175 ABC-type sugar transport systems permease components K17322 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 466.0
TLS2_k127_6641857_8 COG1349 Transcriptional regulators of sugar metabolism K02444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 374.0
TLS2_k127_6641857_9 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002471 278.0
TLS2_k127_6648610_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 0.0 1067.0
TLS2_k127_6648610_1 ABC-type dipeptide transport system periplasmic component K02035 - - 4.847e-262 814.0
TLS2_k127_6648610_10 Xanthine dehydrogenase K13479,K16878 GO:0000166,GO:0003674,GO:0003824,GO:0004854,GO:0005488,GO:0006139,GO:0006144,GO:0006145,GO:0006150,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009114,GO:0009987,GO:0016491,GO:0016725,GO:0016726,GO:0019439,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046100,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071949,GO:0072521,GO:0072523,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575 1.17.1.4,1.3.99.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 335.0
TLS2_k127_6648610_11 Protein of unknown function (DUF2848) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 303.0
TLS2_k127_6648610_12 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 290.0
TLS2_k127_6648610_13 Belongs to the GcvT family K00302,K22086 - 1.5.3.1,1.5.99.5 0.000000000000000000000000000000000004632 140.0
TLS2_k127_6648610_14 Sarcosine oxidase, delta subunit K00304,K22085 - 1.5.3.1,1.5.99.5 0.0000000000000000000000000001579 123.0
TLS2_k127_6648610_16 ThiS family K03636 - - 0.000000000000004164 80.0
TLS2_k127_6648610_2 Belongs to the ABC transporter superfamily K02031,K02032 - - 3.593e-238 749.0
TLS2_k127_6648610_3 FAD dependent oxidoreductase K00303,K22084 - 1.5.3.1,1.5.99.5 2.682e-228 712.0
TLS2_k127_6648610_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 580.0
TLS2_k127_6648610_5 MaoC like domain K14449 GO:0003674,GO:0003824,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046395,GO:0071704,GO:0072329,GO:1901575 4.2.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 524.0
TLS2_k127_6648610_6 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008437 464.0
TLS2_k127_6648610_7 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 416.0
TLS2_k127_6648610_8 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009098 407.0
TLS2_k127_6648610_9 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 335.0
TLS2_k127_6662795_0 UDP binding domain K00012 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 9.563e-220 689.0
TLS2_k127_6662795_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 575.0
TLS2_k127_6662795_2 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008691 358.0
TLS2_k127_6662795_3 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 313.0
TLS2_k127_6662795_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004775 269.0
TLS2_k127_6662795_5 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000002861 235.0
TLS2_k127_6662795_6 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000006716 232.0
TLS2_k127_6662795_7 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000001248 211.0
TLS2_k127_6662795_8 - - - - 0.000000000000000000002082 104.0
TLS2_k127_6683479_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 573.0
TLS2_k127_6683479_1 D-galactarate dehydratase / Altronate hydrolase, C terminus K16846,K16850 - 4.2.1.7,4.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 489.0
TLS2_k127_6683479_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 393.0
TLS2_k127_6683479_3 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 343.0
TLS2_k127_6683479_4 HMGL-like K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 321.0
TLS2_k127_6683479_5 Transcriptional regulator GntR family K03710 - - 0.00000000000000000000000000000000000000000000000000000002541 207.0
TLS2_k127_6683479_6 SAF K16845 - 4.4.1.24 0.0000000000000000000000000000000000000002977 152.0
TLS2_k127_6683479_7 - - - - 0.00007396 53.0
TLS2_k127_6686209_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 1.173e-319 986.0
TLS2_k127_6686209_1 Threonine synthase K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 426.0
TLS2_k127_6686209_2 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 389.0
TLS2_k127_6686209_3 Staphylococcal nuclease homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000943 253.0
TLS2_k127_6686209_4 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000008742 142.0
TLS2_k127_6686209_5 Uncharacterised MFS-type transporter YbfB - - - 0.000284 51.0
TLS2_k127_67687_0 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 1.484e-256 796.0
TLS2_k127_67687_1 Belongs to the aldehyde dehydrogenase family - - - 7.455e-234 736.0
TLS2_k127_67687_2 Glutamate synthase K00265 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 503.0
TLS2_k127_67687_3 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 412.0
TLS2_k127_67687_4 Tetratricopeptide repeat K03671,K05838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 385.0
TLS2_k127_67687_5 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000002388 259.0
TLS2_k127_67687_6 peptidase S16 K01338,K07157 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000002629 239.0
TLS2_k127_67687_7 YbaK prolyl-tRNA synthetase associated K19055 - - 0.00000000000000000000000000000000000000000000000000000000003156 209.0
TLS2_k127_67687_8 Trm112p-like protein K09791 - - 0.000000000000000000113 91.0
TLS2_k127_6777519_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 4.735e-250 777.0
TLS2_k127_6777519_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 586.0
TLS2_k127_6777519_10 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008418 261.0
TLS2_k127_6777519_11 short-chain - - - 0.00000000000000000000000000000000000000000000000000000000001152 216.0
TLS2_k127_6777519_12 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000008002 174.0
TLS2_k127_6777519_13 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000003965 160.0
TLS2_k127_6777519_14 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.000000000000000121 88.0
TLS2_k127_6777519_2 Signal transduction histidine kinase K14980 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 535.0
TLS2_k127_6777519_3 Transcriptional regulatory protein, C terminal K14981 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 435.0
TLS2_k127_6777519_4 Glycosyl transferase family group 2 K20327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 428.0
TLS2_k127_6777519_5 Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide K01479,K01480 - 3.5.3.11,3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 340.0
TLS2_k127_6777519_6 Bacterial periplasmic substrate-binding proteins K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 306.0
TLS2_k127_6777519_7 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005446 286.0
TLS2_k127_6777519_8 Family of unknown function (DUF1028) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002291 285.0
TLS2_k127_6777519_9 PilZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001026 263.0
TLS2_k127_678189_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 5.996e-280 869.0
TLS2_k127_678189_1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.815e-256 800.0
TLS2_k127_678189_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 539.0
TLS2_k127_678189_3 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007536 535.0
TLS2_k127_678189_4 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 477.0
TLS2_k127_678189_5 Prephenate dehydrogenase K00210,K00220,K04517 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 456.0
TLS2_k127_678189_6 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 347.0
TLS2_k127_678189_7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001492 256.0
TLS2_k127_678189_8 protein containing double-stranded beta helix domain - - - 0.00000000000000000000000000000000000000000004075 168.0
TLS2_k127_678189_9 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.0000001802 53.0
TLS2_k127_6803000_0 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 590.0
TLS2_k127_6803000_1 Domain of unknown function (DUF3382) K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005665 571.0
TLS2_k127_6803000_10 MAPEG family - - - 0.0000000000000000002011 89.0
TLS2_k127_6803000_11 Peptidase propeptide and YPEB domain - - - 0.0000000000003655 72.0
TLS2_k127_6803000_12 Belongs to the SOS response-associated peptidase family - - - 0.00000000003529 66.0
TLS2_k127_6803000_13 Response regulator, receiver - - - 0.000000002536 63.0
TLS2_k127_6803000_2 ABC transporter K01995,K15783 GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039 3.5.4.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 433.0
TLS2_k127_6803000_3 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 383.0
TLS2_k127_6803000_4 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009098 315.0
TLS2_k127_6803000_5 Iron-binding zinc finger CDGSH type - - - 0.000000000000000000000000000000004959 128.0
TLS2_k127_6803000_6 Receptor family ligand binding region - - - 0.000000000000000000000000000003228 134.0
TLS2_k127_6803000_7 - - - - 0.00000000000000000000000001804 113.0
TLS2_k127_6803000_8 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.0000000000000000000005337 96.0
TLS2_k127_6803000_9 MAPEG family - - - 0.0000000000000000001125 91.0
TLS2_k127_6842645_0 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 7.094e-261 821.0
TLS2_k127_6842645_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 8.543e-235 743.0
TLS2_k127_6842645_10 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000001865 201.0
TLS2_k127_6842645_11 Asp/Glu/Hydantoin racemase K16841 - 5.1.99.3 0.000000000000000000000000000000000000000000003932 172.0
TLS2_k127_6842645_12 FCD - - - 0.00000000000000000000000000000000000000002289 162.0
TLS2_k127_6842645_13 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000001396 79.0
TLS2_k127_6842645_14 ABC-type dipeptide transport system periplasmic component - - - 0.00000000000001498 77.0
TLS2_k127_6842645_2 Tripartite tricarboxylate transporter TctA family K07793 - - 3.295e-208 662.0
TLS2_k127_6842645_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 5.68e-200 639.0
TLS2_k127_6842645_4 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 407.0
TLS2_k127_6842645_5 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002812 267.0
TLS2_k127_6842645_6 short-chain dehydrogenase reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000146 253.0
TLS2_k127_6842645_7 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000001179 246.0
TLS2_k127_6842645_8 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000007839 245.0
TLS2_k127_6842645_9 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001179 244.0
TLS2_k127_6848325_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1286.0
TLS2_k127_6848325_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0 1114.0
TLS2_k127_6848325_10 PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006138 410.0
TLS2_k127_6848325_11 Belongs to the HpcH HpaI aldolase family K00979,K02510 - 2.7.7.38,4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 342.0
TLS2_k127_6848325_12 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 328.0
TLS2_k127_6848325_13 enoyl-CoA hydratase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 321.0
TLS2_k127_6848325_14 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 327.0
TLS2_k127_6848325_15 Belongs to the BI1 family K06890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009031 307.0
TLS2_k127_6848325_16 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002069 269.0
TLS2_k127_6848325_17 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000000000000000001594 224.0
TLS2_k127_6848325_18 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000122 221.0
TLS2_k127_6848325_19 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000009997 210.0
TLS2_k127_6848325_2 NMT1-like family - - - 3.192e-214 669.0
TLS2_k127_6848325_20 COG0607 Rhodanese-related sulfurtransferase - - - 0.0000000000000000000000000000000000000000000000000000004639 196.0
TLS2_k127_6848325_21 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000001149 156.0
TLS2_k127_6848325_22 - - - - 0.00000000000000000000000000000000003646 139.0
TLS2_k127_6848325_23 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000006372 134.0
TLS2_k127_6848325_24 rRNA binding K02968 - - 0.0000000000000000000005702 99.0
TLS2_k127_6848325_3 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 615.0
TLS2_k127_6848325_4 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007737 593.0
TLS2_k127_6848325_5 Transporter associated domain K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 589.0
TLS2_k127_6848325_6 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 531.0
TLS2_k127_6848325_7 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 512.0
TLS2_k127_6848325_8 Acyclic terpene utilisation family protein AtuA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000458 501.0
TLS2_k127_6848325_9 PFAM Alcohol dehydrogenase zinc-binding domain protein K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 466.0
TLS2_k127_6895061_0 pyruvate phosphate dikinase K01006 - 2.7.9.1 0.0 1257.0
TLS2_k127_6895061_1 Peptidase dimerisation domain K01436 - - 6.645e-217 682.0
TLS2_k127_6895061_10 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000007351 151.0
TLS2_k127_6895061_12 AntiSigma factor - - - 0.0000000000000004953 91.0
TLS2_k127_6895061_14 O-methyltransferase activity - - - 0.0004635 51.0
TLS2_k127_6895061_2 Luciferase-like monooxygenase - - - 8.69e-215 671.0
TLS2_k127_6895061_3 Glycerate kinase family K00865 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005876 434.0
TLS2_k127_6895061_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 412.0
TLS2_k127_6895061_5 HTH-like domain K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005905 249.0
TLS2_k127_6895061_6 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000002374 237.0
TLS2_k127_6895061_7 belongs to the nudix hydrolase family - - - 0.000000000000000000000000000000000000000000000000000002573 203.0
TLS2_k127_6895061_8 Outer membrane protein beta-barrel domain K16079 - - 0.0000000000000000000000000000000000000001032 159.0
TLS2_k127_6895061_9 ETC complex I subunit conserved region K00329 - 1.6.5.3 0.0000000000000000000000000000000000000002157 153.0
TLS2_k127_6927367_0 Acyl-CoA dehydrogenase, middle domain K00249 - 1.3.8.7 8.672e-290 898.0
TLS2_k127_6927367_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009172 591.0
TLS2_k127_6927367_2 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000009703 204.0
TLS2_k127_6927367_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000299 209.0
TLS2_k127_6927367_4 Protein of unknwon function (DUF3008) - - - 0.0000000000000000006486 87.0
TLS2_k127_6927367_5 Iron-containing alcohol dehydrogenase K00043,K13954 - 1.1.1.1,1.1.1.61 0.0000000004652 61.0
TLS2_k127_6927367_6 EamA-like transporter family - - - 0.000000003857 67.0
TLS2_k127_6959036_0 Sodium:solute symporter family K14393 - - 0.0 1131.0
TLS2_k127_6959036_1 TIGRFAM amidase, hydantoinase carbamoylase family K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000756 522.0
TLS2_k127_6959036_10 - - - - 0.0000000000000000000000000005717 119.0
TLS2_k127_6959036_2 Maleate cis-trans isomerase K01799 - 5.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 399.0
TLS2_k127_6959036_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000006188 231.0
TLS2_k127_6959036_4 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000000000000000000005856 217.0
TLS2_k127_6959036_5 Domain of unknown function (DUF4340) - - - 0.0000000000000000000000000000000000000000000000002769 190.0
TLS2_k127_6959036_6 ABC-type uncharacterized transport system K01992 - - 0.000000000000000000000000000000000000000000006733 167.0
TLS2_k127_6959036_7 - - - - 0.000000000000000000000000000000000000000004176 162.0
TLS2_k127_6959036_8 - - - - 0.0000000000000000000000000000000000000001099 153.0
TLS2_k127_6959036_9 Domain of unknown function (DUF4212) - - - 0.00000000000000000000000000000000002959 138.0
TLS2_k127_6972209_0 DNA polymerase K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1515.0
TLS2_k127_6972209_1 Tripartite tricarboxylate transporter TctA family K07793 - - 2.228e-218 687.0
TLS2_k127_6972209_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004333 390.0
TLS2_k127_6972209_3 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 344.0
TLS2_k127_6972209_4 COG0402 Cytosine deaminase and related metal-dependent hydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 318.0
TLS2_k127_6972209_5 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000003658 159.0
TLS2_k127_6972209_6 membrane K07794 - - 0.0000000000000001963 86.0
TLS2_k127_7083306_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1386.0
TLS2_k127_7083306_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 1.128e-222 697.0
TLS2_k127_7083306_10 Catechol dioxygenase N terminus K03381 - 1.13.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 380.0
TLS2_k127_7083306_11 MotA/TolQ/ExbB proton channel family K03562 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006849 366.0
TLS2_k127_7083306_12 PFAM metallophosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 364.0
TLS2_k127_7083306_13 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 336.0
TLS2_k127_7083306_14 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007694 299.0
TLS2_k127_7083306_15 Lysine exporter protein LysE YggA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004324 283.0
TLS2_k127_7083306_16 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009503 257.0
TLS2_k127_7083306_17 Protein of unknown function (DUF1009) K09949 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000003915 235.0
TLS2_k127_7083306_18 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000000000000000000000001748 193.0
TLS2_k127_7083306_19 Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000000000000000000000000000000000000000000002124 186.0
TLS2_k127_7083306_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.032e-208 659.0
TLS2_k127_7083306_20 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000002689 160.0
TLS2_k127_7083306_21 membrane K03646 - - 0.00000000000000000000000000000000000000002381 167.0
TLS2_k127_7083306_22 Protein of unknown function (DUF2385) - - - 0.000000000000000000000000000000000000007945 153.0
TLS2_k127_7083306_24 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000000000005784 139.0
TLS2_k127_7083306_25 - - - - 0.0000000000000000000000000001316 117.0
TLS2_k127_7083306_27 lysine biosynthetic process via aminoadipic acid K00997,K06133 - 2.7.8.7 0.0000000000000001225 89.0
TLS2_k127_7083306_28 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000001493 74.0
TLS2_k127_7083306_29 Protein of unknown function (DUF1192) - - - 0.0000000000002277 73.0
TLS2_k127_7083306_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 577.0
TLS2_k127_7083306_30 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000006417 70.0
TLS2_k127_7083306_31 - - - - 0.000001012 54.0
TLS2_k127_7083306_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 544.0
TLS2_k127_7083306_5 Transketolase, pyrimidine binding domain K21417 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 496.0
TLS2_k127_7083306_6 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 477.0
TLS2_k127_7083306_7 Dehydrogenase E1 component K21416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 422.0
TLS2_k127_7083306_8 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 423.0
TLS2_k127_7083306_9 UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 405.0
TLS2_k127_7087840_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 4.793e-261 809.0
TLS2_k127_7087840_1 periplasmic solute binding protein K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 310.0
TLS2_k127_7087840_2 Alpha beta hydrolase K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 314.0
TLS2_k127_7087840_3 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000001285 228.0
TLS2_k127_7091575_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0 1163.0
TLS2_k127_7091575_1 COG0277 FAD FMN-containing dehydrogenases K00004,K00102 GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.1.1.303,1.1.1.4,1.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007622 601.0
TLS2_k127_7091575_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 576.0
TLS2_k127_7091575_3 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 482.0
TLS2_k127_7091575_4 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000001659 93.0
TLS2_k127_7106953_0 Elongation factor SelB, winged helix K03833 - - 1.886e-237 764.0
TLS2_k127_7106953_1 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 8.079e-236 734.0
TLS2_k127_7106953_2 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 560.0
TLS2_k127_7106953_3 4Fe-4S dicluster domain K00124,K21308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 484.0
TLS2_k127_7106953_4 Necessary for formate dehydrogenase activity K02380 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 314.0
TLS2_k127_7106953_5 formate dehydrogenase K00127 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 284.0
TLS2_k127_7106953_6 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000005934 237.0
TLS2_k127_7106953_7 Glycine cleavage H-protein K02437 - - 0.00000000000000000000000000000000000000000000001779 175.0
TLS2_k127_7106953_8 - - - - 0.00000000000000000000000000000000000000007852 155.0
TLS2_k127_711556_0 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.0 1082.0
TLS2_k127_711556_1 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 1.585e-300 930.0
TLS2_k127_711556_10 cell cycle - - - 0.0000000000000009066 80.0
TLS2_k127_711556_2 Phage SPO1 DNA K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000929 334.0
TLS2_k127_711556_3 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000699 324.0
TLS2_k127_711556_4 Protein of unknown function (DUF1194) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009392 272.0
TLS2_k127_711556_6 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000005215 178.0
TLS2_k127_711556_7 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.0000000000000000000000000000000000000000000009009 170.0
TLS2_k127_711556_8 Cellulose biosynthesis protein BcsS - - - 0.00000000000000000000000001633 119.0
TLS2_k127_711556_9 transcription activator, effector binding K13652 - - 0.0000000000000000009716 94.0
TLS2_k127_714311_0 Alpha/beta hydrolase family K01561 - 3.8.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000832 426.0
TLS2_k127_714311_1 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007621 372.0
TLS2_k127_714311_10 LysE type translocator K11250 - - 0.000000000000000000000000000256 122.0
TLS2_k127_714311_12 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000006895 99.0
TLS2_k127_714311_13 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000009301 63.0
TLS2_k127_714311_2 Bacterial protein of unknown function (DUF882) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 376.0
TLS2_k127_714311_3 Belongs to the mandelate racemase muconate lactonizing enzyme family K01684 - 4.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 334.0
TLS2_k127_714311_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K09565 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 285.0
TLS2_k127_714311_5 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007292 255.0
TLS2_k127_714311_6 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K09565 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000003368 231.0
TLS2_k127_714311_7 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000567 221.0
TLS2_k127_714311_8 FR47-like protein - - - 0.00000000000000000000000000000000000000000000000000000000004123 209.0
TLS2_k127_714311_9 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.0000000000000000000000000000000000000000000000000000006969 196.0
TLS2_k127_7254178_0 glutamine synthetase K01915 - 6.3.1.2 1.617e-263 824.0
TLS2_k127_7254178_1 Function of homologous gene experimentally demonstrated in an other organism K01624 - 4.1.2.13 3.345e-205 646.0
TLS2_k127_7254178_2 COG2041 Sulfite oxidase and related enzymes K00387 - 1.8.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 571.0
TLS2_k127_7254178_3 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.00000000000000000000000000000000000000000000000000000000004364 206.0
TLS2_k127_7254178_4 Belongs to the 'phage' integrase family - - - 0.0000000000000000000001718 102.0
TLS2_k127_7254178_5 Tetratricopeptide repeat - - - 0.00003866 57.0
TLS2_k127_726687_0 Periplasmic binding protein K01999 - - 2.821e-237 736.0
TLS2_k127_726687_1 Peptidase family M20/M25/M40 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 542.0
TLS2_k127_726687_10 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000008758 192.0
TLS2_k127_726687_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 464.0
TLS2_k127_726687_3 COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 445.0
TLS2_k127_726687_4 branched-chain amino acid K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 432.0
TLS2_k127_726687_5 COG4608 ABC-type oligopeptide transport system, ATPase component K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 437.0
TLS2_k127_726687_6 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 401.0
TLS2_k127_726687_7 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 391.0
TLS2_k127_726687_8 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000008603 230.0
TLS2_k127_726687_9 Iron-regulated protein - - - 0.00000000000000000000000000000000000000000000000000003516 203.0
TLS2_k127_7288769_0 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0 1048.0
TLS2_k127_7288769_1 ABC-type multidrug transport system ATPase and permease K06147,K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 597.0
TLS2_k127_7288769_2 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 563.0
TLS2_k127_7288769_3 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003737 250.0
TLS2_k127_7288769_4 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000005044 144.0
TLS2_k127_7360353_0 COG1228 Imidazolonepropionase and related amidohydrolases - - - 1.134e-200 633.0
TLS2_k127_7360353_1 COG1228 Imidazolonepropionase and related amidohydrolases - - - 3.871e-200 630.0
TLS2_k127_7360353_2 TOBE domain K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006084 514.0
TLS2_k127_7360353_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00446 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 508.0
TLS2_k127_7360353_4 Binding-protein-dependent transport system inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 394.0
TLS2_k127_7360353_5 Bacterial extracellular solute-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 377.0
TLS2_k127_7377352_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1247.0
TLS2_k127_7377352_1 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1047.0
TLS2_k127_7377352_10 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 347.0
TLS2_k127_7377352_11 cytochrome c1 K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 351.0
TLS2_k127_7377352_12 Protein of unknown function (DUF459) K09795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 347.0
TLS2_k127_7377352_13 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 314.0
TLS2_k127_7377352_14 LppC putative lipoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 319.0
TLS2_k127_7377352_15 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000938 281.0
TLS2_k127_7377352_16 Rhodanese-like domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000007268 252.0
TLS2_k127_7377352_17 helix_turn_helix ASNC type K03719 - - 0.00000000000000000000000000000000000000000000000000000000000000004646 226.0
TLS2_k127_7377352_18 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000009216 206.0
TLS2_k127_7377352_19 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000008447 205.0
TLS2_k127_7377352_2 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 0.0 1027.0
TLS2_k127_7377352_20 ROS/MUCR transcriptional regulator protein - - - 0.00000000000000000000000000000000000000000000000002644 188.0
TLS2_k127_7377352_21 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000000000001232 121.0
TLS2_k127_7377352_22 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000001593 117.0
TLS2_k127_7377352_23 - - - - 0.0000000000004723 74.0
TLS2_k127_7377352_24 - - - - 0.0000001824 58.0
TLS2_k127_7377352_3 GMC oxidoreductase - - - 2.466e-233 734.0
TLS2_k127_7377352_4 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00410,K00412 - - 4.542e-227 708.0
TLS2_k127_7377352_5 Belongs to the prokaryotic GSH synthase family K01920 GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009558 510.0
TLS2_k127_7377352_6 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 504.0
TLS2_k127_7377352_7 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009252 489.0
TLS2_k127_7377352_8 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 454.0
TLS2_k127_7377352_9 lytic murein transglycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 444.0
TLS2_k127_7382366_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 6.14e-236 746.0
TLS2_k127_7382366_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 542.0
TLS2_k127_7382366_2 Peptidase dimerisation domain K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 396.0
TLS2_k127_7382366_3 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000003709 170.0
TLS2_k127_7382366_4 signal peptide protein - - - 0.000000000000000000000000000000000000000002089 160.0
TLS2_k127_7382366_5 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000002783 161.0
TLS2_k127_7382366_6 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000004215 148.0
TLS2_k127_7382366_7 SnoaL-like domain - - - 0.000000000000000000000000000000008164 133.0
TLS2_k127_7382366_8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000000000000000007371 117.0
TLS2_k127_7382366_9 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000000001207 79.0
TLS2_k127_784160_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain II K15778 - 5.4.2.2,5.4.2.8 1.624e-270 840.0
TLS2_k127_784160_1 TIGRFAM TRAP transporter, DctM subunit - - - 3.456e-199 631.0
TLS2_k127_784160_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 533.0
TLS2_k127_784160_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001976 271.0
TLS2_k127_784160_4 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000001897 254.0
TLS2_k127_784160_5 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000000000000028 228.0
TLS2_k127_784160_6 MoaE protein K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000006695 171.0
TLS2_k127_784160_7 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.00000000000000000000000000000001352 130.0
TLS2_k127_797597_0 Glycine cleavage T-protein C-terminal barrel domain K00302,K22086 - 1.5.3.1,1.5.99.5 0.0 1249.0
TLS2_k127_797597_1 Esterase-like activity of phytase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 323.0
TLS2_k127_797597_2 Sarcosine oxidase, gamma subunit family K22087 - 1.5.99.5 0.000000000000000000000000003091 120.0
TLS2_k127_797597_3 Cobalamin biosynthesis protein CobT K09883 - 6.6.1.2 0.000000000005107 66.0
TLS2_k127_81873_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 6.967e-195 612.0
TLS2_k127_81873_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 469.0
TLS2_k127_81873_2 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 294.0
TLS2_k127_81873_3 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000723 235.0
TLS2_k127_81873_4 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000004059 229.0
TLS2_k127_81873_5 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000007342 220.0
TLS2_k127_8266_0 NADH-quinone oxidoreductase K00336 - 1.6.5.3 0.0 1035.0
TLS2_k127_8266_1 PFAM acyl-CoA dehydrogenase K14448 - 1.3.8.12 7.475e-257 803.0
TLS2_k127_8266_10 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 319.0
TLS2_k127_8266_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K19595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 330.0
TLS2_k127_8266_12 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000009328 244.0
TLS2_k127_8266_13 Belongs to the UPF0061 (SELO) family K08997 - - 0.00000000000000000000000000000000000000000000000000000000001578 211.0
TLS2_k127_8266_14 Electron transfer DM13 - - - 0.0000000000000000000000000000000000000000000000000000000001221 207.0
TLS2_k127_8266_15 PhoP regulatory network protein YrbL - - - 0.00000000000000000000000000000000000005962 152.0
TLS2_k127_8266_16 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000001179 122.0
TLS2_k127_8266_17 - - - - 0.000000000000000000006207 95.0
TLS2_k127_8266_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11745,K11747 - - 4.902e-246 772.0
TLS2_k127_8266_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 524.0
TLS2_k127_8266_4 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 499.0
TLS2_k127_8266_5 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 479.0
TLS2_k127_8266_6 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 481.0
TLS2_k127_8266_7 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 474.0
TLS2_k127_8266_8 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 361.0
TLS2_k127_8266_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006046 333.0
TLS2_k127_88001_0 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.0 1148.0
TLS2_k127_88001_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1079.0
TLS2_k127_88001_10 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000000000000000002263 192.0
TLS2_k127_88001_11 Protein of unknown function (DUF448) K07742 - - 0.00000000000000000000000000000000000000000000000001485 190.0
TLS2_k127_88001_12 carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000000000000000000000000000000000005383 141.0
TLS2_k127_88001_13 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000245 93.0
TLS2_k127_88001_2 Participates in both transcription termination and antitermination K02600 - - 1.14e-271 844.0
TLS2_k127_88001_3 Aminotransferase class-III K16871 - 2.6.1.96 1.765e-199 631.0
TLS2_k127_88001_4 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 527.0
TLS2_k127_88001_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 466.0
TLS2_k127_88001_6 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 431.0
TLS2_k127_88001_7 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 389.0
TLS2_k127_88001_8 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 336.0
TLS2_k127_88001_9 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000001249 227.0
TLS2_k127_887301_0 CoA binding domain K09181 - - 4.518e-230 731.0
TLS2_k127_887301_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 541.0
TLS2_k127_887301_2 Thiolase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 539.0
TLS2_k127_887301_3 Metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 433.0
TLS2_k127_887301_4 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 363.0
TLS2_k127_887301_5 Universal stress protein family - - - 0.00000000000000000000000000000001463 133.0
TLS2_k127_887301_6 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000000000000000000000002178 123.0
TLS2_k127_924923_0 Terminase RNaseH-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 445.0
TLS2_k127_924923_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000006315 250.0
TLS2_k127_924923_2 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000002683 248.0
TLS2_k127_924923_3 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000003237 224.0
TLS2_k127_924923_4 TadE-like protein K02651 - - 0.000000000000000000000000000000000009886 143.0
TLS2_k127_924923_5 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000668 141.0
TLS2_k127_924923_6 - - - - 0.0000000000000000000000000000002589 129.0
TLS2_k127_924923_7 Flp pilus assembly protein TadG - - - 0.00000000000000000000004616 107.0