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Overview

ID MAG04010
Name TLS2_bin.49
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Burkholderiaceae
Genus Rubrivivax
Species
Assembly information
Completeness (%) 72.4
Contamination (%) 2.77
GC content (%) 69.0
N50 (bp) 4,539
Genome size (bp) 2,464,807

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2599

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1005851_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 3.85e-293 931.0
TLS2_k127_1005851_1 Belongs to the TPP enzyme family K04103 - 4.1.1.74 0.000000000003094 68.0
TLS2_k127_1010654_0 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 495.0
TLS2_k127_1010654_1 TIGRFAM homoprotocatechuate degradation operon regulator, HpaR - - - 0.000000000000000000000000000000000000000000000000000000000000000000003286 237.0
TLS2_k127_1010654_2 Fumarylacetoacetate (FAA) hydrolase family K05921 - 4.1.1.68 0.000000000000000000004939 96.0
TLS2_k127_1010654_3 enzyme involved in biosynthesis of extracellular polysaccharides - - - 0.0000000000000000002611 94.0
TLS2_k127_101066_0 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 336.0
TLS2_k127_101066_1 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 298.0
TLS2_k127_101066_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009405 271.0
TLS2_k127_101066_3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000001246 180.0
TLS2_k127_101066_4 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000248 158.0
TLS2_k127_101066_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000003942 60.0
TLS2_k127_1026098_0 AMP-binding enzyme C-terminal domain K18661 - - 3.444e-256 799.0
TLS2_k127_1026098_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.19e-219 689.0
TLS2_k127_1026098_2 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.000000000001341 68.0
TLS2_k127_1026098_3 Cysteine-rich CWC - - - 0.000000000003905 72.0
TLS2_k127_1027508_0 Protein of unknown function (DUF808) K09781 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 386.0
TLS2_k127_1027508_1 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.0000000000000000000000000000000000000000000000000000001948 194.0
TLS2_k127_1027508_2 TIR domain - - - 0.0000000000000000000000000000000000000000000000000000005448 202.0
TLS2_k127_103626_0 TonB dependent receptor K02014 - - 0.0 1023.0
TLS2_k127_103626_1 ABC transporter K15738 - - 2.444e-238 745.0
TLS2_k127_103626_2 Major facilitator Superfamily K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008989 561.0
TLS2_k127_103626_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 422.0
TLS2_k127_103626_4 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003774 288.0
TLS2_k127_103626_5 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000000000005557 211.0
TLS2_k127_103626_6 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000000000000000000000000000000000000004254 217.0
TLS2_k127_103626_7 - - - - 0.0000000000000000001686 93.0
TLS2_k127_1044754_0 Two component transcriptional regulator, winged helix family K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 317.0
TLS2_k127_1044754_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000002371 227.0
TLS2_k127_1048095_0 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005937 385.0
TLS2_k127_1048095_1 Lipid A biosynthesis acyltransferase K02517,K12974 - 2.3.1.241,2.3.1.242 0.00000000000000000000000000000000000000000000000000000000000000000000000000001607 263.0
TLS2_k127_1048095_2 Protein of unknown function, DUF484 K09921 - - 0.000000000000000000000000000000000000000000009221 177.0
TLS2_k127_1050031_0 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 5.896e-261 813.0
TLS2_k127_1050031_1 Belongs to the UPF0061 (SELO) family - - - 2.229e-218 690.0
TLS2_k127_1050031_2 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 348.0
TLS2_k127_1050031_3 Belongs to the BolA IbaG family K05527 - - 0.00000000000000000000000005126 110.0
TLS2_k127_1050031_4 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0002382 50.0
TLS2_k127_1050576_0 SpoVR like protein K06415 - - 4.108e-314 968.0
TLS2_k127_1050576_1 Belongs to the UPF0229 family K09786 - - 3.424e-241 749.0
TLS2_k127_1050576_2 Citrate transporter - - - 0.0000000000000000008298 87.0
TLS2_k127_1050576_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000001351 86.0
TLS2_k127_1054499_0 Regulator K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 315.0
TLS2_k127_1054499_1 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000009157 269.0
TLS2_k127_1054499_2 CBS domain - - - 0.00000000000000000000001886 106.0
TLS2_k127_1054499_3 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway K00351 - 1.6.5.8 0.00000000000000000000006681 98.0
TLS2_k127_1065628_0 type II secretion system protein E K02454,K02652,K12276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000958 572.0
TLS2_k127_1065628_1 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 512.0
TLS2_k127_1066898_0 HflC and HflK could encode or regulate a protease K04088 - - 7.964e-195 614.0
TLS2_k127_1066898_1 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006337 472.0
TLS2_k127_1066898_2 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003433 281.0
TLS2_k127_1066898_3 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.000000000000000004474 85.0
TLS2_k127_1077127_0 Belongs to the IlvD Edd family K01690 - 4.2.1.12 3.113e-296 918.0
TLS2_k127_1077127_1 RarD protein, DMT superfamily transporter K05786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006248 343.0
TLS2_k127_1077127_2 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase K01625 - 4.1.2.14,4.1.3.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 333.0
TLS2_k127_1077127_3 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 313.0
TLS2_k127_1077127_4 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.000000000000000000000000000000002957 132.0
TLS2_k127_1100798_0 DNA polymerase III K02342 - 2.7.7.7 3.182e-263 833.0
TLS2_k127_1100798_1 His Kinase A (phospho-acceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006866 380.0
TLS2_k127_1100798_2 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000001931 214.0
TLS2_k127_1100798_3 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000002991 183.0
TLS2_k127_1101718_0 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 572.0
TLS2_k127_1101718_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009111 406.0
TLS2_k127_1101718_2 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 336.0
TLS2_k127_1101718_3 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 302.0
TLS2_k127_1101718_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000000000000000000000000000000000000000087 231.0
TLS2_k127_1101718_5 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000000000000000006981 203.0
TLS2_k127_1101718_6 TM2 domain - - - 0.0000000000000000000000000000000000000000000000007619 179.0
TLS2_k127_1101718_7 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.00000000000000000000000000000000000000000000004408 175.0
TLS2_k127_1101718_8 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000000000000000001148 147.0
TLS2_k127_1111191_0 phosphatase K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 407.0
TLS2_k127_1111191_1 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009191 356.0
TLS2_k127_1111191_2 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 356.0
TLS2_k127_1111191_3 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 312.0
TLS2_k127_1111191_4 PFAM Protein kinase K11912,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000002235 248.0
TLS2_k127_1111806_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1571.0
TLS2_k127_1111806_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 7.029e-203 640.0
TLS2_k127_1111806_2 PA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 522.0
TLS2_k127_1111806_3 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 366.0
TLS2_k127_1111806_4 peptidase K08259 - 3.4.24.75 0.0000000000000000000000000000000000000000000000000000000000000000000001415 243.0
TLS2_k127_1128500_0 DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 504.0
TLS2_k127_1128500_1 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008741 476.0
TLS2_k127_1128500_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000001255 252.0
TLS2_k127_1128500_3 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000009072 214.0
TLS2_k127_1128500_4 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.0000000000000000000000000000000000000000000004819 173.0
TLS2_k127_1163330_0 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006294 436.0
TLS2_k127_1163330_1 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000000001367 236.0
TLS2_k127_1163330_2 Glutathione peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000004575 210.0
TLS2_k127_1163330_3 Bacterial SH3 domain - - - 0.0000000000000000000000000000000000000001412 152.0
TLS2_k127_1181159_0 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 1.949e-242 756.0
TLS2_k127_1194875_0 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004588 466.0
TLS2_k127_1194875_1 helix_turn_helix ASNC type - - - 0.00000000000000000006587 103.0
TLS2_k127_1201798_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006183 558.0
TLS2_k127_1201798_1 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 400.0
TLS2_k127_1201798_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000002624 221.0
TLS2_k127_1201798_3 PFAM peptidase M61 domain protein - - - 0.00000000000000000000000000000001123 131.0
TLS2_k127_1201798_4 Zinc-finger domain - - - 0.00000000000000000000000000004488 117.0
TLS2_k127_1229405_0 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 511.0
TLS2_k127_1229405_1 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 332.0
TLS2_k127_1229405_2 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 GO:0003674,GO:0003824,GO:0004362,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0022900,GO:0031974,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0098869,GO:1901360,GO:1990748 1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 306.0
TLS2_k127_1229405_3 Sel1 repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003541 267.0
TLS2_k127_1230929_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 370.0
TLS2_k127_1230929_1 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000008662 190.0
TLS2_k127_1230929_2 Diguanylate cyclase, GGDEF domain - - - 0.00000003274 62.0
TLS2_k127_1232450_0 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004591 607.0
TLS2_k127_1232450_1 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K04090 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 531.0
TLS2_k127_1232450_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 487.0
TLS2_k127_1232450_3 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009842 469.0
TLS2_k127_1232450_4 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001678 264.0
TLS2_k127_1232450_5 Cytochrome B561 K12262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000289 262.0
TLS2_k127_1232450_6 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000001007 235.0
TLS2_k127_1232450_7 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000000000000000001129 229.0
TLS2_k127_1232450_8 YceI-like domain - - - 0.0000000000000000000000000000000000000000000000000000000838 203.0
TLS2_k127_1240110_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 3.717e-204 637.0
TLS2_k127_1240110_1 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006207 423.0
TLS2_k127_1240110_2 aminopeptidase N K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 417.0
TLS2_k127_1240110_3 - - - - 0.00000000002385 64.0
TLS2_k127_1245468_0 Alpha amylase catalytic region K01182,K01187,K05343 - 3.2.1.1,3.2.1.10,3.2.1.20,5.4.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 361.0
TLS2_k127_1245468_1 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000000000000000000003104 216.0
TLS2_k127_1245468_2 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000004296 163.0
TLS2_k127_1256823_0 GTP-binding protein K06207 - - 0.0 1081.0
TLS2_k127_1256823_1 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 541.0
TLS2_k127_1256823_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 380.0
TLS2_k127_1256823_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000002173 200.0
TLS2_k127_1256823_4 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000002189 168.0
TLS2_k127_1262444_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 392.0
TLS2_k127_1262444_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K01947,K03525 - 2.7.1.33,6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 385.0
TLS2_k127_1262444_2 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003401 323.0
TLS2_k127_1262444_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000000000001687 202.0
TLS2_k127_1262444_4 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.00000000000000000000000007625 108.0
TLS2_k127_1277514_0 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 569.0
TLS2_k127_1277514_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007618 517.0
TLS2_k127_1277514_2 Phosphate transport system permease K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 439.0
TLS2_k127_1277514_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0004604 43.0
TLS2_k127_1277514_4 dipeptide transport K02035 - - 0.0004827 44.0
TLS2_k127_130873_0 Esterase PHB depolymerase K03932 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 449.0
TLS2_k127_130873_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000001522 203.0
TLS2_k127_1327337_0 NMT1-like family K02051,K15576 - - 4.397e-257 797.0
TLS2_k127_1327337_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008845 556.0
TLS2_k127_1327337_2 Acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 482.0
TLS2_k127_1327337_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 308.0
TLS2_k127_1327337_4 Chloramphenicol acetyltransferase K19271 - 2.3.1.28 0.0000000000000000000000000000000000000000000003095 175.0
TLS2_k127_1358532_0 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 518.0
TLS2_k127_1358532_1 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 397.0
TLS2_k127_1358532_2 Ribosome-associated heat shock protein K04762 - - 0.000000000000000000000000000000000000004636 149.0
TLS2_k127_1358532_3 Response regulator, receiver K02483 - - 0.00000000000000000000000000000000001248 139.0
TLS2_k127_1365723_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 1.957e-247 771.0
TLS2_k127_1365723_1 Trypsin-like peptidase domain - - - 9.361e-207 652.0
TLS2_k127_1365723_2 Belongs to the arginase family K01476,K01480,K12255,K18459 - 3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 557.0
TLS2_k127_1365723_3 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000557 458.0
TLS2_k127_1365723_4 Peptidase C26 K01658,K07010 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 374.0
TLS2_k127_1365723_5 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 365.0
TLS2_k127_1365723_6 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000002512 107.0
TLS2_k127_1373980_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1116.0
TLS2_k127_1373980_1 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 408.0
TLS2_k127_1373980_2 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 377.0
TLS2_k127_1373980_3 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007471 340.0
TLS2_k127_1373980_4 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009426 330.0
TLS2_k127_1373980_5 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 295.0
TLS2_k127_1373980_6 Flagellar protein FliT K02423 - - 0.0000000000000000000000000000000000000001429 152.0
TLS2_k127_1373980_7 Type II transport protein GspH K08084,K08085 - - 0.00000000000000000000000000000000001114 142.0
TLS2_k127_1373980_8 flagellar protein FliS K02422 - - 0.000000000000000000000000000001172 126.0
TLS2_k127_1373980_9 Prokaryotic N-terminal methylation motif K02655 - - 0.0000000000000000000000000583 121.0
TLS2_k127_1382097_0 NADPH-dependent glutamate synthase beta - - - 2.934e-271 839.0
TLS2_k127_1382097_1 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006065 555.0
TLS2_k127_1382097_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 404.0
TLS2_k127_1382097_3 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000001437 292.0
TLS2_k127_1382097_4 - - - - 0.000000000000000000000000000000000006334 151.0
TLS2_k127_1394589_0 TIGRFAM sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009682 359.0
TLS2_k127_1394589_1 protein, hemolysin III K11068 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007722 312.0
TLS2_k127_1394589_2 Thioredoxin K00384 - 1.8.1.9 0.000000000000000000000000000000002402 134.0
TLS2_k127_1401420_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 1.266e-210 660.0
TLS2_k127_1401420_1 NADH flavin oxidoreductase NADH oxidase K10680 GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 545.0
TLS2_k127_1401420_2 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 437.0
TLS2_k127_1401420_3 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 422.0
TLS2_k127_1401420_4 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006125 423.0
TLS2_k127_1408240_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 1.884e-201 631.0
TLS2_k127_1408240_1 PFAM 20S proteasome, A and B subunits K07395 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 473.0
TLS2_k127_1408240_2 Succinylglutamate desuccinylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 337.0
TLS2_k127_1408240_3 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000001478 267.0
TLS2_k127_1421572_0 formate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 469.0
TLS2_k127_1421572_1 PIN domain - - - 0.000000000000000000000000002988 115.0
TLS2_k127_1421572_2 TIGRFAM looped-hinge helix DNA binding domain, AbrB family - - - 0.000000007211 60.0
TLS2_k127_1426934_0 TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase K01740 - 2.5.1.49 2.743e-234 734.0
TLS2_k127_1426934_1 FAD linked oxidases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 584.0
TLS2_k127_1426934_2 UPF0761 membrane protein K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 523.0
TLS2_k127_1426934_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 325.0
TLS2_k127_1426934_4 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000593 237.0
TLS2_k127_1426934_5 Predicted membrane protein (DUF2069) - - - 0.00000000000000000000000000000000001 139.0
TLS2_k127_1426934_6 histidine kinase HAMP region domain protein K03406,K03776,K05874,K05875 - - 0.0000008653 61.0
TLS2_k127_1432292_0 binding-protein-dependent transport systems inner membrane component K02025,K05814,K10118,K17242,K17245 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008552 453.0
TLS2_k127_1432292_1 Binding-protein-dependent transport system inner membrane component K02026,K05815,K17246 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 285.0
TLS2_k127_1432292_2 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000004717 235.0
TLS2_k127_1441987_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003557 258.0
TLS2_k127_1441987_1 Histidine kinase K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000001049 190.0
TLS2_k127_1441987_2 - - - - 0.0000000000000000000000000000000000000000000004603 179.0
TLS2_k127_1441987_3 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 0.00000000000000000000000000000000000005775 147.0
TLS2_k127_1442562_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.364e-272 842.0
TLS2_k127_1442562_1 Protein of unknown function (DUF938) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000076 243.0
TLS2_k127_1442562_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000001467 209.0
TLS2_k127_1442562_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000001011 79.0
TLS2_k127_1458278_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009091 621.0
TLS2_k127_1458278_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 587.0
TLS2_k127_1458278_2 HDOD domain - - - 0.00000000000000000000000006704 109.0
TLS2_k127_1476971_0 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 1.845e-207 651.0
TLS2_k127_1476971_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 297.0
TLS2_k127_1478878_0 AMP-binding enzyme K01895 - 6.2.1.1 2.144e-283 883.0
TLS2_k127_1478878_1 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006224 417.0
TLS2_k127_1478878_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003819 246.0
TLS2_k127_1482217_0 Proton-conducting membrane transporter K12141 - - 3.894e-281 870.0
TLS2_k127_1482217_1 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 377.0
TLS2_k127_1482217_2 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009468 351.0
TLS2_k127_151221_0 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007587 419.0
TLS2_k127_151221_1 HAD-hyrolase-like K22292 - 3.1.3.105 0.000000000000000000000000000000000000000000000000000000000000000000000000001294 265.0
TLS2_k127_151221_2 Belongs to the 'phage' integrase family - - - 0.0000000000000000001491 89.0
TLS2_k127_1512579_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 382.0
TLS2_k127_1512579_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 296.0
TLS2_k127_1512579_2 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000005279 127.0
TLS2_k127_1539501_0 Flagellar motor switch K02416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008621 596.0
TLS2_k127_1539501_1 Plays a role in the flagellum-specific transport system K02419 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 374.0
TLS2_k127_1539501_2 Flagellar motor switch protein fliN K02417,K03225 - - 0.0000000000000000000000000000000000000000000000000000000000000003503 222.0
TLS2_k127_1539501_3 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.0000000000000000000000000000000000000000000000000000000000145 212.0
TLS2_k127_1539501_4 Flagellar biosynthesis protein, FliO K02418 - - 0.00000000000000000000000004584 111.0
TLS2_k127_1546784_0 Alpha amylase catalytic region K01176 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 513.0
TLS2_k127_1546784_1 major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 421.0
TLS2_k127_1546784_2 Histidine kinase K05962,K07716 - 2.7.13.1,2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 391.0
TLS2_k127_1546784_3 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000001939 212.0
TLS2_k127_1579328_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 587.0
TLS2_k127_1579328_1 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 368.0
TLS2_k127_1579328_2 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007497 370.0
TLS2_k127_1579328_3 Protein of unknown function (DUF3299) K09950 - - 0.000000000000000000000000000000000000000000000000000000000000002797 241.0
TLS2_k127_1579328_4 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000002197 76.0
TLS2_k127_1582299_0 Dehydrogenase E1 component K00164 - 1.2.4.2 3.902e-316 971.0
TLS2_k127_1582299_1 acyl-CoA dehydrogenase K20035 - - 3.378e-257 799.0
TLS2_k127_1582299_2 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 521.0
TLS2_k127_1588081_0 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 442.0
TLS2_k127_1588081_1 - - - - 0.0000000000000000000000000000000000003923 158.0
TLS2_k127_1596765_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K13482 - 1.17.1.4 0.0 1045.0
TLS2_k127_1596765_1 CO dehydrogenase flavoprotein domain protein K13481 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 379.0
TLS2_k127_1596765_2 TIGRFAM xanthine dehydrogenase accessory protein XdhC K07402 - - 0.0000000000000000000000008304 116.0
TLS2_k127_1597736_0 Putative amidoligase enzyme (DUF2126) - - - 2.436e-307 947.0
TLS2_k127_1597736_1 A predicted alpha-helical domain with a conserved ER motif. - - - 0.000000000000000000000000000000000001337 148.0
TLS2_k127_1602165_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1147.0
TLS2_k127_1602165_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 8.17e-288 891.0
TLS2_k127_1602165_2 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 537.0
TLS2_k127_1602165_3 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007071 336.0
TLS2_k127_1602165_4 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 289.0
TLS2_k127_1602165_5 Belongs to the P(II) protein family K04751,K04752 - - 0.000000000000000000000000000000000000000000000000000000000001823 210.0
TLS2_k127_1602165_6 RDD family - - - 0.0000000000000000000000000000000000000000000000000000002069 203.0
TLS2_k127_1602165_7 Protein of unknown function (DUF3106) - - - 0.000000000000000000000000000000000000000000000000000212 195.0
TLS2_k127_1602165_8 Protein of unknown function (DUF3619) - - - 0.00000000001268 65.0
TLS2_k127_1607482_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 1.073e-197 622.0
TLS2_k127_1607482_1 electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 486.0
TLS2_k127_1607482_2 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 434.0
TLS2_k127_1607482_3 - - - - 0.000000000000000000000006737 104.0
TLS2_k127_1611469_0 TIGRFAM decaheme c-type cytochrome, OmcA MtrC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 338.0
TLS2_k127_1611469_1 cytochrome C family protein - - - 0.000000000000000000000000000000000000000000000000000001371 206.0
TLS2_k127_1611469_2 Helix-hairpin-helix motif - - - 0.0000000001387 68.0
TLS2_k127_1614100_0 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 448.0
TLS2_k127_1614100_1 Major Facilitator Superfamily K07552,K18552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005556 255.0
TLS2_k127_1614100_2 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000000000000000000000000000000000000008353 231.0
TLS2_k127_1622863_0 Proton-conducting membrane transporter K00342 - 1.6.5.3 3.582e-228 719.0
TLS2_k127_1622863_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 514.0
TLS2_k127_1622863_2 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 463.0
TLS2_k127_1628243_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 444.0
TLS2_k127_1628243_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 424.0
TLS2_k127_1628243_2 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 398.0
TLS2_k127_1634099_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 496.0
TLS2_k127_1634099_1 PFAM MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 381.0
TLS2_k127_1634099_2 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004118 245.0
TLS2_k127_1634099_3 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000000000000000000000000000000000000000000003717 219.0
TLS2_k127_1634099_4 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000006302 183.0
TLS2_k127_1636784_0 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 325.0
TLS2_k127_1636784_1 SCP-2 sterol transfer family - - - 0.000000000000000000000000000000000000000000000000000003656 195.0
TLS2_k127_1636784_2 Bacterial regulatory proteins, luxR family K07684 - - 0.00000000000000000000000000000000000000000000000002366 181.0
TLS2_k127_1636784_3 Insulinase (Peptidase family M16) K07263 - - 0.000176 44.0
TLS2_k127_1644830_0 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 505.0
TLS2_k127_1644830_1 Biotin-lipoyl like K03585,K07799,K18901 - - 0.0000000000000000000000000000000000000000000000000000007174 202.0
TLS2_k127_1648980_0 cytochrome c biogenesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 406.0
TLS2_k127_1648980_1 sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000005323 216.0
TLS2_k127_1648980_3 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000001917 216.0
TLS2_k127_1648980_4 Protein of unknown function (DUF1109) - - - 0.000000000000000000000000000000000000000000006704 170.0
TLS2_k127_1648980_5 Thioredoxin-like - - - 0.000000000000000000000000000000000000000004905 157.0
TLS2_k127_1656988_0 Subtilase family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007299 506.0
TLS2_k127_1656988_1 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 372.0
TLS2_k127_1656988_2 Sporulation domain protein - - - 0.00000000000000000000000000000000000000000000000008018 185.0
TLS2_k127_1656988_3 Cysteine-rich motif following a subset of SET domains K07117 - - 0.0000000000000000000000002326 105.0
TLS2_k127_1661249_0 Belongs to the ClpA ClpB family K03694 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 455.0
TLS2_k127_1661249_1 Belongs to the MtfA family K09933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000394 353.0
TLS2_k127_1661249_2 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 334.0
TLS2_k127_1671152_0 Proton-conducting membrane transporter - - - 2.41e-215 683.0
TLS2_k127_1671152_1 Proton-conducting membrane transporter - - - 1.901e-208 684.0
TLS2_k127_1671152_2 Na H antiporter, MnhB K05566 - - 0.00000000000000000000000000000000000000000000000000000000000000001714 228.0
TLS2_k127_1671152_3 Na H antiporter, MnhB K05566 - - 0.0000000000000000000000000000000000000000000000000000000000001196 223.0
TLS2_k127_1671152_4 COG1006 Multisubunit Na H antiporter, MnhC subunit K05567 - - 0.0000000000000000000000000000000000000003889 159.0
TLS2_k127_1671152_5 monovalent cation:proton antiporter activity K05571 - - 0.00000000000000000000000000000000000006205 148.0
TLS2_k127_1671152_6 Multiple resistance and pH regulation protein F K05570 - - 0.000000000000000000000003866 102.0
TLS2_k127_1671291_0 Signal transducing histidine kinase, homodimeric K03407 GO:0003674,GO:0005488,GO:0005515,GO:0019904 2.7.13.3 6.875e-243 758.0
TLS2_k127_1671291_1 Two component signalling adaptor domain K03408 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001001 252.0
TLS2_k127_1671562_0 Pfam:HipA_N - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 493.0
TLS2_k127_1671562_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 485.0
TLS2_k127_1671562_2 GGDEF domain - - - 0.000000000000000000000000000000000000000000000001575 200.0
TLS2_k127_1674696_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 1.348e-255 795.0
TLS2_k127_1674696_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 5.901e-223 700.0
TLS2_k127_1674696_2 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 518.0
TLS2_k127_1674696_3 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 301.0
TLS2_k127_1674696_4 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001593 255.0
TLS2_k127_1676384_0 N-terminal domain of oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 354.0
TLS2_k127_1682431_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 1.503e-194 627.0
TLS2_k127_1682431_1 RHS Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008232 346.0
TLS2_k127_1682431_2 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.0000000000000000000000000001047 117.0
TLS2_k127_1685299_0 Tetratricopeptide repeat - - - 5.511e-251 813.0
TLS2_k127_1685299_1 Required for the activity of the bacterial periplasmic transport system of putrescine K11073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000735 587.0
TLS2_k127_1685299_10 PEP-CTERM motif - - - 0.0000000000001428 81.0
TLS2_k127_1685299_2 Domain of unknown function (DUF4397) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002329 272.0
TLS2_k127_1685299_3 NnrU protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000242 254.0
TLS2_k127_1685299_4 dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000004099 233.0
TLS2_k127_1685299_5 Thioredoxin-like - - - 0.000000000000000000000000000000000000000000000000000000000000005487 228.0
TLS2_k127_1685299_6 Protein of unknown function (DUF456) K09793 - - 0.000000000000000000000000000000000000000000000000000000000005841 222.0
TLS2_k127_1685299_7 Domain of unknown function (DUF427) - - - 0.0000000000000000000000000000000000000000000000005937 176.0
TLS2_k127_1685299_8 ornithine cyclodeaminase K01750,K19743 - 1.5.1.1,4.3.1.12 0.0000000000000000000000000000000000000001015 156.0
TLS2_k127_1685299_9 Belongs to the pirin family K06911 - - 0.0000000000000002606 86.0
TLS2_k127_1690116_0 transcription factor binding K02584,K12146,K12266,K15836,K21009 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006772 495.0
TLS2_k127_1690116_1 regulatory protein Crp K01420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 306.0
TLS2_k127_1690116_2 Fe-S-cluster oxidoreductase K06940 - - 0.0000000000000000000000000000000000716 134.0
TLS2_k127_1690116_3 Protein of unknown function (DUF2892) - - - 0.00000000000000000003226 95.0
TLS2_k127_1699408_0 Nicotinamide mononucleotide transporter K03811 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 289.0
TLS2_k127_1699408_1 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000001817 233.0
TLS2_k127_1699408_2 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000007457 211.0
TLS2_k127_1699408_3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.0000000000000000000000000000000004844 133.0
TLS2_k127_1699408_4 Domain of unknown function (DUF4276) - - - 0.000000000000000000000000000001266 128.0
TLS2_k127_1699408_5 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000005864 116.0
TLS2_k127_1712672_0 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001281 254.0
TLS2_k127_1712672_1 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00000000000000000000000000000000000007947 154.0
TLS2_k127_1715230_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.0 1021.0
TLS2_k127_1715230_1 Histidine Phosphotransfer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 455.0
TLS2_k127_1715230_2 MerR, DNA binding K19591,K19592 - - 0.00000000000000000000000000000000000000000000000000000001155 201.0
TLS2_k127_1715230_3 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000001597 207.0
TLS2_k127_1715230_4 PAS fold K10715,K20974 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000391 195.0
TLS2_k127_1715230_5 Heavy-metal-associated domain K07213 - - 0.000000000000000002806 87.0
TLS2_k127_1727513_0 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 426.0
TLS2_k127_1727513_1 Virulence factor membrane-bound polymerase, C-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 412.0
TLS2_k127_1727513_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000001191 261.0
TLS2_k127_1729658_0 Protein of unknown function (DUF1631) - - - 6.737e-236 749.0
TLS2_k127_1729658_1 Trypsin K04691,K04772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 488.0
TLS2_k127_1729658_2 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 469.0
TLS2_k127_1733583_0 formate hydrogenlyase subunit 3 multisubunit Na H antiporter, MnhD subunit K05568,K12137 - - 1.683e-244 767.0
TLS2_k127_1733583_1 - - - - 0.0000000000000000000000241 100.0
TLS2_k127_1739691_0 Methyltransferase domain K02169 - 2.1.1.197 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 323.0
TLS2_k127_1739691_1 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000000000000000000000000211 256.0
TLS2_k127_1739691_2 PFAM Phosphoribosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003765 248.0
TLS2_k127_1739691_3 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000001271 165.0
TLS2_k127_1770784_0 molybdopterin K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 562.0
TLS2_k127_1770784_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 451.0
TLS2_k127_1772813_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005528 434.0
TLS2_k127_1772813_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002801 270.0
TLS2_k127_1772813_2 Fe-S-cluster oxidoreductase K06940 - - 0.000000000000000000000000000000000000002185 147.0
TLS2_k127_1772813_3 TfoX C-terminal domain K07343 - - 0.0000000000000000000000001085 110.0
TLS2_k127_1774082_0 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 464.0
TLS2_k127_1774082_1 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 328.0
TLS2_k127_1774082_2 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 K15461 - 2.1.1.61 0.0000000000000000000000000000000000000000000000000000000001939 208.0
TLS2_k127_1774082_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000000000002993 127.0
TLS2_k127_1774082_4 - - - - 0.0000000001593 73.0
TLS2_k127_1778749_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 3.156e-292 905.0
TLS2_k127_1778749_1 Sporulation related domain - - - 0.0000000000000000000000000000000000000004897 154.0
TLS2_k127_1778749_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000001155 166.0
TLS2_k127_1784172_0 TIGRFAM ribonuclease, Rne Rng family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 574.0
TLS2_k127_1784172_1 Nucleotidyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000662 281.0
TLS2_k127_1784172_2 - - - - 0.00000000000000000000000000000000000000000000004076 174.0
TLS2_k127_1785786_0 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction K03656 - 3.6.4.12 0.0 1041.0
TLS2_k127_1785786_1 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000000000000000000000000000000001003 203.0
TLS2_k127_1785786_2 - - - - 0.000000000000000000000000000000000117 139.0
TLS2_k127_1785786_3 FIST_C - - - 0.00000000003256 63.0
TLS2_k127_1792032_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 1.966e-258 805.0
TLS2_k127_1792032_1 Protein of unknown function (DUF1298) - - - 0.00000000000000000000000000000000000000000000000000000000004795 206.0
TLS2_k127_1792032_2 negative regulation of translational initiation - - - 0.0000000000000000000000000000000000000000000000000002802 188.0
TLS2_k127_1805993_0 1-carboxyvinyltransferase K00790 - 2.5.1.7 6.388e-219 689.0
TLS2_k127_1805993_1 histidine kinase HAMP region domain protein K03406,K03776,K05874,K05875 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 588.0
TLS2_k127_1805993_2 Belongs to the SUA5 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 342.0
TLS2_k127_1805993_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008669 280.0
TLS2_k127_1805993_4 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006536 265.0
TLS2_k127_1805993_5 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000003176 181.0
TLS2_k127_1805993_6 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.000000000000000000000000000000000000000001366 156.0
TLS2_k127_1809832_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 5.513e-243 763.0
TLS2_k127_1817739_0 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 372.0
TLS2_k127_1817739_1 Asparaginase K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 349.0
TLS2_k127_1817739_2 peptidase S45, penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007101 269.0
TLS2_k127_1817739_3 Pathogenicity locus K07343 - - 0.00000000000000000000000000000000000000004278 162.0
TLS2_k127_1817739_4 ABC transporter K06158 - - 0.0000000003744 61.0
TLS2_k127_1823139_0 Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity K14540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 349.0
TLS2_k127_1823139_1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000003147 241.0
TLS2_k127_184578_0 Na H antiporter MnhB subunit-related protein - - - 0.0 1159.0
TLS2_k127_184578_1 NADH Ubiquinone plastoquinone (Complex I) K05561 - - 1.015e-202 644.0
TLS2_k127_184578_2 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 451.0
TLS2_k127_184578_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 378.0
TLS2_k127_184578_4 UPF0114 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 299.0
TLS2_k127_184578_5 NADH-ubiquinone oxidoreductase chain 4L K05560 - - 0.00000000000000000000000000000000000000000000209 170.0
TLS2_k127_184578_6 antiporter K05562 - - 0.00000000000000000000000000000000000000000001741 168.0
TLS2_k127_184578_7 Na+/H+ antiporter subunit K05564 - - 0.0000000000000000000000000000000000002352 144.0
TLS2_k127_184578_8 Multiple resistance and pH regulation protein F K05563 - - 0.0000000000000000000000001132 118.0
TLS2_k127_1847051_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0 1159.0
TLS2_k127_1847051_1 GGDEF domain - - - 1.078e-309 971.0
TLS2_k127_1847051_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 2.285e-248 780.0
TLS2_k127_1873352_0 Ammonium Transporter K03320,K06580 - - 8.116e-231 720.0
TLS2_k127_1873352_1 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 469.0
TLS2_k127_1873352_2 Cysteine-rich secretory protein family - - - 0.00000000000000000006567 94.0
TLS2_k127_1874730_0 alcohol dehydrogenase K00043,K13954 - 1.1.1.1,1.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 537.0
TLS2_k127_1874730_1 PFAM Alpha beta hydrolase fold-3 domain protein K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007276 450.0
TLS2_k127_1874730_2 Thioesterase superfamily protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 402.0
TLS2_k127_1874730_3 Belongs to the GcvT family K06980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 393.0
TLS2_k127_1874730_4 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001625 266.0
TLS2_k127_187609_0 carbohydrate binding K13688 - - 0.0 1665.0
TLS2_k127_1880235_0 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 353.0
TLS2_k127_1880235_1 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 308.0
TLS2_k127_1880235_2 Protein of unknown function (DUF4254) - - - 0.000000000000000000000000000000000000000000000000000000000002307 224.0
TLS2_k127_1880235_3 Helix-hairpin-helix motif K02237 - - 0.000000000000000000000000005795 113.0
TLS2_k127_1884534_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 1.283e-213 674.0
TLS2_k127_1884534_1 Histidine kinase K02484 - 2.7.13.3 0.0000000000000000000000000000003361 124.0
TLS2_k127_1884534_2 - - - - 0.0000000000000000000000003745 110.0
TLS2_k127_1893899_0 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 571.0
TLS2_k127_1893899_1 COG0790 FOG TPR repeat, SEL1 subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 438.0
TLS2_k127_1893899_2 Predicted membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006897 271.0
TLS2_k127_1893899_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000007564 160.0
TLS2_k127_1899387_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000809 561.0
TLS2_k127_1899387_1 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 548.0
TLS2_k127_1899387_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003739 254.0
TLS2_k127_1902657_0 Single cache domain 3 K02482 - 2.7.13.3 3.18e-249 783.0
TLS2_k127_1902657_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03387 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 336.0
TLS2_k127_1914322_0 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 616.0
TLS2_k127_1914322_1 Aldo/keto reductase family K19265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006335 265.0
TLS2_k127_1924393_0 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008782 325.0
TLS2_k127_1924393_1 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 304.0
TLS2_k127_1924393_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000002125 114.0
TLS2_k127_1949041_0 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007761 363.0
TLS2_k127_1949041_1 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 353.0
TLS2_k127_1949041_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 296.0
TLS2_k127_1949041_3 Biopolymer transport protein ExbD TolR K03559 - - 0.0000000000000000000000000000000000000000000000000000000003686 207.0
TLS2_k127_1949041_4 Belongs to the UPF0434 family K09791 - - 0.0000000000000000000000000756 108.0
TLS2_k127_1949041_5 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000002504 96.0
TLS2_k127_1968777_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 1.536e-303 964.0
TLS2_k127_1968777_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 3.268e-235 735.0
TLS2_k127_1968777_2 Resistance to Hg(2 ) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) K00520,K21739 - 1.16.1.1 2.855e-226 709.0
TLS2_k127_1968777_3 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 421.0
TLS2_k127_1968777_4 Protein of unknown function (DUF3667) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001543 260.0
TLS2_k127_1968777_5 GCN5-related N-acetyl-transferase K06975 - - 0.00000000000000000000001465 104.0
TLS2_k127_1982010_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 7.127e-225 719.0
TLS2_k127_1982010_1 PFAM coagulation factor 5 8 type domain protein - - - 0.0000000000000000000000000000000000000000009221 162.0
TLS2_k127_1993476_0 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009166 590.0
TLS2_k127_1993476_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 580.0
TLS2_k127_1999943_0 Belongs to the DegT DnrJ EryC1 family - - - 1.116e-202 638.0
TLS2_k127_1999943_1 Glycosyl transferase 4-like domain - - - 4.168e-194 613.0
TLS2_k127_1999943_2 UDP-N-acetylglucosamine 2-epimerase K01791,K13019 - 5.1.3.14,5.1.3.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 506.0
TLS2_k127_1999943_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004421 291.0
TLS2_k127_1999943_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000000000000000000000000000000000000000000000001766 177.0
TLS2_k127_1999943_5 Putative restriction endonuclease - - - 0.0000000000000000000000001553 110.0
TLS2_k127_1999943_6 - - - - 0.00000000000000001879 85.0
TLS2_k127_1999943_7 Glycosyltransferase Family 4 - - - 0.00000007736 54.0
TLS2_k127_2015500_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 4.116e-239 754.0
TLS2_k127_2015500_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 577.0
TLS2_k127_2015500_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001582 254.0
TLS2_k127_2015500_3 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000000000003958 158.0
TLS2_k127_2015633_0 mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006298 360.0
TLS2_k127_2015633_1 Tetracycline transcriptional repressor MAATS-type K03577 - - 0.000000000000000000000000000000000000000000000000000001133 203.0
TLS2_k127_2015633_2 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 0.00000000000000000000000000000001752 131.0
TLS2_k127_2023269_0 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 399.0
TLS2_k127_2023269_1 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 308.0
TLS2_k127_2034508_0 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 1.084e-203 640.0
TLS2_k127_2034508_1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005211 248.0
TLS2_k127_2037136_0 AMP-binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007274 615.0
TLS2_k127_2037136_1 glutaminyl-tRNA synthetase K01886 - 6.1.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 487.0
TLS2_k127_2037136_2 MMPL family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008153 399.0
TLS2_k127_2037136_3 Bacterial lipid A biosynthesis acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 379.0
TLS2_k127_2037136_4 FKBP-type peptidyl-prolyl cis-trans isomerase K03772,K03773 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000001597 199.0
TLS2_k127_2037136_5 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000000125 187.0
TLS2_k127_2037136_6 membrane - - - 0.0000000000000000000000000000000000000000002199 165.0
TLS2_k127_2037136_8 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000000000003538 121.0
TLS2_k127_2039486_0 Belongs to the argininosuccinate synthase family. Type 2 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 6.507e-267 825.0
TLS2_k127_2039486_1 - - - - 3.7e-201 642.0
TLS2_k127_2039486_2 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 449.0
TLS2_k127_2039486_3 Protein of unknown function (DUF1499) - - - 0.00000000000000000000000000000000000000000000000000000000102 206.0
TLS2_k127_2039486_4 helix_turn_helix gluconate operon transcriptional repressor - - - 0.0000000000000000000000000000000000000000000000002219 179.0
TLS2_k127_2047992_0 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101,K00104 - 1.1.2.3,1.1.3.15 6.378e-220 687.0
TLS2_k127_2047992_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002361 258.0
TLS2_k127_2047992_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000003024 209.0
TLS2_k127_2072882_0 2Fe-2S iron-sulfur cluster binding domain K00523 - 1.17.1.1 7.098e-197 635.0
TLS2_k127_2072882_1 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 336.0
TLS2_k127_2072882_2 Peptidase S24-like - - - 0.00000000000000000000000000001112 134.0
TLS2_k127_2095154_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 1.18e-227 710.0
TLS2_k127_2095154_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 582.0
TLS2_k127_2095154_10 Glutaminase K01425 - 3.5.1.2 0.0000000000000000000931 102.0
TLS2_k127_2095154_11 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000001378 54.0
TLS2_k127_2095154_2 MatE K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009177 582.0
TLS2_k127_2095154_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 535.0
TLS2_k127_2095154_4 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 409.0
TLS2_k127_2095154_5 Glutaminase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 411.0
TLS2_k127_2095154_6 Protein of unknown function (DUF3717) K06938 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002072 256.0
TLS2_k127_2095154_7 Regulator K01420 - - 0.000000000000000000000000000000000000000000000000000000000000000000001014 254.0
TLS2_k127_2095154_8 Peptidyl-prolyl cis-trans isomerase K03774 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000001269 217.0
TLS2_k127_2095154_9 Heavy-metal resistance - - - 0.00000000000000000000000000000001267 135.0
TLS2_k127_2100492_0 Histidine kinase - - - 0.0 1013.0
TLS2_k127_2100492_1 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 345.0
TLS2_k127_2100492_2 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000000000000000000000000000000000000000006071 223.0
TLS2_k127_2100492_3 - - - - 0.000003635 50.0
TLS2_k127_2113587_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1445.0
TLS2_k127_2113587_1 PIN domain - - - 0.00000000000000000000000000009984 123.0
TLS2_k127_2113587_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000005436 67.0
TLS2_k127_2113854_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 602.0
TLS2_k127_2113854_1 Transcriptional regulator, LysR family K21699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 407.0
TLS2_k127_2113854_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 297.0
TLS2_k127_2115031_0 AMP-binding enzyme K01912 - 6.2.1.30 4.246e-203 641.0
TLS2_k127_2115031_1 Wzy family polymerase, exosortase system type 1 associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 476.0
TLS2_k127_2115031_2 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006196 346.0
TLS2_k127_2115031_3 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000005856 167.0
TLS2_k127_2116764_0 phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 496.0
TLS2_k127_2116764_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 392.0
TLS2_k127_2116764_2 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001089 236.0
TLS2_k127_2116764_3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000008969 87.0
TLS2_k127_2138853_0 response regulator receiver K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006878 493.0
TLS2_k127_2138853_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000003324 199.0
TLS2_k127_2164136_0 twitching motility protein K02669,K12203 - - 1.122e-197 621.0
TLS2_k127_2164136_1 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 320.0
TLS2_k127_2164136_2 helix_turn_helix ASNC type K03719 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002763 253.0
TLS2_k127_2176893_0 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 4.369e-207 646.0
TLS2_k127_2176893_1 PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit K00122 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 325.0
TLS2_k127_2179357_0 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 304.0
TLS2_k127_2179357_1 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000000000000000000000001216 209.0
TLS2_k127_2179357_2 diguanylate cyclase - - - 0.00000000000000000000000000007331 121.0
TLS2_k127_2179357_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000549 98.0
TLS2_k127_2182452_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 537.0
TLS2_k127_2182452_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007295 430.0
TLS2_k127_2182452_2 abc transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 351.0
TLS2_k127_2182452_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000002067 168.0
TLS2_k127_2185286_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005015 338.0
TLS2_k127_2185286_1 PFAM Cytochrome c oxidase assembly protein CtaG Cox11 K02258 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001593 289.0
TLS2_k127_2185286_2 Cytochrome c oxidase subunit K02276 - 1.9.3.1 0.00000000000000000000000000000000000000181 150.0
TLS2_k127_2185286_3 Protein of unknown function (DUF2970) - - - 0.0000000000000000009851 94.0
TLS2_k127_222342_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 3.25e-293 916.0
TLS2_k127_222342_1 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 571.0
TLS2_k127_222342_2 Phosphoribulokinase / Uridine kinase family K00855 - 2.7.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 536.0
TLS2_k127_222342_3 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003984 524.0
TLS2_k127_222342_4 carbohydrate phosphatase activity K01086 - 3.1.3.11,3.1.3.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 288.0
TLS2_k127_222342_5 Glutathione peroxidase K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000001819 258.0
TLS2_k127_222342_6 subfamily IA, variant 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003171 256.0
TLS2_k127_222342_7 acyl-coA-binding protein - - - 0.000000000000000000000000000000000042 136.0
TLS2_k127_2235977_0 Virulence factor membrane-bound polymerase, C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 435.0
TLS2_k127_2235977_1 O-antigen ligase like membrane protein - - - 0.0000000003893 72.0
TLS2_k127_2239176_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 1.93e-321 996.0
TLS2_k127_2239176_1 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 452.0
TLS2_k127_2239176_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 370.0
TLS2_k127_2239176_3 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003516 271.0
TLS2_k127_2239176_4 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004043 255.0
TLS2_k127_2239176_5 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000003591 239.0
TLS2_k127_2247874_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 2.1e-288 890.0
TLS2_k127_2247874_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 439.0
TLS2_k127_2247874_2 Belongs to the peptidase S11 family K07262 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 394.0
TLS2_k127_2247874_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000003425 186.0
TLS2_k127_2247874_4 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.00000000000000000000000000000000000000000000003604 173.0
TLS2_k127_225400_0 PFAM fumarate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 489.0
TLS2_k127_225400_1 Belongs to the argininosuccinate synthase family. Type K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 309.0
TLS2_k127_225400_2 cellulase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008764 295.0
TLS2_k127_225400_3 sister chromatid segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002837 286.0
TLS2_k127_225400_4 cellulase activity - - - 0.00000000000000000000000000000000000000000000000000000000000002059 232.0
TLS2_k127_225400_5 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000000004944 149.0
TLS2_k127_2259680_0 - - - - 0.0 1087.0
TLS2_k127_2259680_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 510.0
TLS2_k127_2259680_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 459.0
TLS2_k127_2259680_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005063 300.0
TLS2_k127_2259680_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000123 281.0
TLS2_k127_2259680_5 - - - - 0.0000000000000000000004164 107.0
TLS2_k127_2268083_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1753.0
TLS2_k127_2268083_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 6.183e-201 654.0
TLS2_k127_2268083_2 PFAM Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 321.0
TLS2_k127_2268083_3 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005444 285.0
TLS2_k127_2268083_4 COG1863 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000000000000000000000000000000000000000000003816 198.0
TLS2_k127_2296200_0 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 476.0
TLS2_k127_2296200_1 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008442 286.0
TLS2_k127_2296200_2 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000002803 221.0
TLS2_k127_2305826_0 PFAM Cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 575.0
TLS2_k127_2305826_1 Threonyl alanyl tRNA synthetase SAD K07050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 376.0
TLS2_k127_2305826_2 PFAM Creatininase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 346.0
TLS2_k127_2305826_3 hydrolase of the alpha K07019 - - 0.000006504 51.0
TLS2_k127_2332805_0 type II secretion system protein K K02460 - - 0.00000000000000293 89.0
TLS2_k127_2332805_1 - - - - 0.000000000000008259 86.0
TLS2_k127_2332805_2 Prokaryotic N-terminal methylation motif K02459 - - 0.00000004833 63.0
TLS2_k127_2332805_3 - - - - 0.0000003449 61.0
TLS2_k127_2334059_0 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 505.0
TLS2_k127_2334059_1 helix_turn _helix lactose operon repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 424.0
TLS2_k127_2334059_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 386.0
TLS2_k127_2334059_3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000000000000000000000000000000000000009464 220.0
TLS2_k127_2334059_4 TonB-dependent Receptor Plug Domain - - - 0.0000000000000000000000000000000000000001085 158.0
TLS2_k127_2334059_5 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000037 139.0
TLS2_k127_234600_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 4.867e-301 933.0
TLS2_k127_2347268_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0 1354.0
TLS2_k127_2347268_1 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 388.0
TLS2_k127_2347300_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 6.163e-250 776.0
TLS2_k127_2347300_1 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 509.0
TLS2_k127_2361763_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 5.787e-245 760.0
TLS2_k127_2361763_1 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 491.0
TLS2_k127_2361763_2 Glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 327.0
TLS2_k127_2361763_3 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000000001355 165.0
TLS2_k127_2361763_4 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000726 134.0
TLS2_k127_2361763_5 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000001296 108.0
TLS2_k127_2361763_6 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.00000000007693 63.0
TLS2_k127_2361763_7 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.00001418 55.0
TLS2_k127_2365259_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 3.289e-216 677.0
TLS2_k127_2365259_1 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008211 557.0
TLS2_k127_2365259_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006825 466.0
TLS2_k127_2365259_3 Required for insertion of 4Fe-4S clusters K15724 - - 0.0000000000000000000000000000000000000000000000000000000000000000009983 228.0
TLS2_k127_2365259_4 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000000001413 180.0
TLS2_k127_2365259_5 - - - - 0.00000000000000000000000000000000000000008299 155.0
TLS2_k127_2365259_6 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000001444 147.0
TLS2_k127_2379642_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007606 608.0
TLS2_k127_2379642_1 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006563 348.0
TLS2_k127_2379642_2 phosphoglycerate mutase K15634 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000002467 258.0
TLS2_k127_2379642_3 Copper chaperone PCu(A)C K09796 - - 0.0000000000000000000000000000000000005238 145.0
TLS2_k127_2379642_4 Domain of unknown function (DUF1840) - - - 0.00000000000000000000000000007381 120.0
TLS2_k127_238426_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0 1311.0
TLS2_k127_238426_1 Belongs to the thiolase family K00626 - 2.3.1.9 4.055e-214 674.0
TLS2_k127_238426_2 Poly(R)-hydroxyalkanoic acid synthase, class I K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 535.0
TLS2_k127_238426_3 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA K06917 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000329 475.0
TLS2_k127_238426_4 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 442.0
TLS2_k127_238426_5 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 317.0
TLS2_k127_238426_6 Protein of unknown function (DUF2788) - - - 0.0000000000000000000000000006718 126.0
TLS2_k127_2390590_0 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008962 608.0
TLS2_k127_2390590_1 PFAM Polysaccharide deacetylase K01452 - 3.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 571.0
TLS2_k127_2390590_2 OHCU decarboxylase K02083,K06016 - 3.5.1.6,3.5.1.87,3.5.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002501 296.0
TLS2_k127_2390590_3 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.00000000000000000000000000000000000000000000000000000002489 200.0
TLS2_k127_2418509_0 Bifunctional enoyl-CoA hydratase phosphate acetyltransferase K00625 - 2.3.1.8 1.384e-239 747.0
TLS2_k127_2418509_1 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007043 590.0
TLS2_k127_2418509_2 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000111 229.0
TLS2_k127_2418509_3 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000001582 213.0
TLS2_k127_244906_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K11473 - - 2.668e-212 670.0
TLS2_k127_244906_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 483.0
TLS2_k127_244906_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 330.0
TLS2_k127_244906_3 PFAM FAD linked oxidase domain protein K00104,K11472 - 1.1.3.15 0.00000000000000000000000000001483 119.0
TLS2_k127_2478427_0 Alpha amylase, C-terminal all-beta domain K00700 - 2.4.1.18 0.0 1190.0
TLS2_k127_2478427_1 PFAM glycoside hydrolase, family 13 domain protein K01214,K02438 - 3.2.1.196,3.2.1.68 2.349e-292 918.0
TLS2_k127_2478427_2 4-alpha-glucanotransferase K00705 - 2.4.1.25 6.632e-248 773.0
TLS2_k127_2478427_3 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 405.0
TLS2_k127_2478427_4 Sigma-70, region 4 K02405 - - 0.000000000000000000000000000000000000000000009521 170.0
TLS2_k127_2552142_0 PFAM histone deacetylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 486.0
TLS2_k127_2552142_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006173 446.0
TLS2_k127_2552142_2 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000001191 89.0
TLS2_k127_2556362_0 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009828 460.0
TLS2_k127_2556362_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 430.0
TLS2_k127_2556362_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005828 326.0
TLS2_k127_2563331_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 1.246e-210 662.0
TLS2_k127_2563331_1 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000001247 102.0
TLS2_k127_2563331_2 - - - - 0.00000001049 63.0
TLS2_k127_2572616_0 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 561.0
TLS2_k127_2572616_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 406.0
TLS2_k127_2572616_2 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007626 355.0
TLS2_k127_2572616_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008702 274.0
TLS2_k127_2572616_4 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000001393 233.0
TLS2_k127_2572616_5 rRNA methyltransferase K03437 - - 0.0000000000000000000005373 106.0
TLS2_k127_2573724_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1320.0
TLS2_k127_2573724_1 L-serine dehydratase K01752 - 4.3.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 512.0
TLS2_k127_2573724_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000002393 176.0
TLS2_k127_2573773_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 344.0
TLS2_k127_2573773_1 - - - - 0.0000000000000000000000000009842 125.0
TLS2_k127_2587087_0 response regulator K02667 - - 5.472e-210 663.0
TLS2_k127_2587087_1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009733 604.0
TLS2_k127_2587087_2 His Kinase A (phosphoacceptor) domain K02668,K10125 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008944 381.0
TLS2_k127_2592702_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 437.0
TLS2_k127_2592702_1 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 321.0
TLS2_k127_2592702_2 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000003522 220.0
TLS2_k127_2595334_0 Response regulator of the LytR AlgR family - GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 310.0
TLS2_k127_2595334_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000003882 259.0
TLS2_k127_2595334_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000009938 237.0
TLS2_k127_2595334_3 - - - - 0.000000000000000000000000000000000000000000000002782 195.0
TLS2_k127_2595334_4 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 0.0000000000000000000000001656 109.0
TLS2_k127_2595334_5 Domain of unknown function (DUF4936) - - - 0.000000938 57.0
TLS2_k127_259578_0 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 475.0
TLS2_k127_259578_1 Histidine-specific methyltransferase, SAM-dependent - - - 0.00000000000000000000000000000000000000000000000000000000000000000004624 238.0
TLS2_k127_259578_2 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000002513 183.0
TLS2_k127_2596998_0 homolog of phage Mu protein gp47 - - - 0.0 1260.0
TLS2_k127_2596998_1 Late control gene D protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 608.0
TLS2_k127_2596998_2 Baseplate J-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 514.0
TLS2_k127_2596998_3 Baseplate assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 301.0
TLS2_k127_2596998_4 - - - - 0.00000000000000000000000000000000000000000000000000000000344 199.0
TLS2_k127_2596998_5 Gene 25-like lysozyme K06903 - - 0.000000000000000000000000000000000000000000000000002742 189.0
TLS2_k127_2596998_6 LysM domain - - - 0.0000000000000000000000000000000000000000000001369 173.0
TLS2_k127_2596998_7 - - - - 0.0000000000000000000002562 97.0
TLS2_k127_2599734_0 KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 578.0
TLS2_k127_2599734_1 GGDEF domain - - - 0.00000000000000000000001371 110.0
TLS2_k127_2599734_2 KaiB domain protein K08481 - - 0.000000000000000001754 91.0
TLS2_k127_2599734_3 Putative diguanylate phosphodiesterase - - - 0.0000003243 53.0
TLS2_k127_2605317_0 acetylornithine K00821 - 2.6.1.11,2.6.1.17 1.01e-200 631.0
TLS2_k127_2605317_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 591.0
TLS2_k127_2605317_2 PFAM fumarylacetoacetate (FAA) hydrolase K18336 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 493.0
TLS2_k127_2605317_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 358.0
TLS2_k127_2605317_4 Peptidase family M28 K01295 - 3.4.17.11 0.00000000000000000004538 91.0
TLS2_k127_2612107_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008446,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 4.2.1.47 8.913e-207 661.0
TLS2_k127_2612107_1 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 507.0
TLS2_k127_2612107_2 Type II secretory pathway, component PulD K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 415.0
TLS2_k127_2612107_3 Glycosyl transferase, family 2 - - - 0.0000000000009008 77.0
TLS2_k127_2620295_0 Elongation factor G, domain IV K02355 - - 0.0 1072.0
TLS2_k127_2620295_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006177 254.0
TLS2_k127_2644263_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 4.479e-254 796.0
TLS2_k127_2644263_1 Protein of unknown function (DUF692) K09930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 411.0
TLS2_k127_2644263_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 353.0
TLS2_k127_2644263_3 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 344.0
TLS2_k127_2644263_4 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007579 312.0
TLS2_k127_2644263_5 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002103 287.0
TLS2_k127_2644263_6 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000002017 236.0
TLS2_k127_2644263_7 Putative DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001532 239.0
TLS2_k127_2644263_8 DoxX family K15977 - - 0.0000000000000000000000000000000000000000000000000000000002361 211.0
TLS2_k127_2644263_9 Predicted integral membrane protein (DUF2282) - - - 0.00000000000000000000000000000000006364 137.0
TLS2_k127_2648338_0 general secretion pathway protein K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 595.0
TLS2_k127_2648338_1 Protein of unknown function (DUF815) K06923 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 486.0
TLS2_k127_2648338_10 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000000000000000001438 120.0
TLS2_k127_2648338_11 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.000000000000000004842 93.0
TLS2_k127_2648338_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 422.0
TLS2_k127_2648338_3 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000002666 245.0
TLS2_k127_2648338_4 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000000000000001806 219.0
TLS2_k127_2648338_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000000000000000000000000000000000000000000001949 212.0
TLS2_k127_2648338_6 membrane - - - 0.0000000000000000000000000000000000000000000000000000003202 201.0
TLS2_k127_2648338_7 Phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000000000000000000000000000000001844 184.0
TLS2_k127_2648338_8 Bacterial regulatory proteins, tetR family K05501 - - 0.00000000000000000000000000000000000000000003291 162.0
TLS2_k127_2648338_9 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.000000000000000000000000000000006084 127.0
TLS2_k127_2654049_0 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 521.0
TLS2_k127_2654049_1 exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 426.0
TLS2_k127_2678379_0 Transcriptional regulatory protein, C terminal K02483,K07666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004604 351.0
TLS2_k127_2678379_1 Cytochrome b/b6/petB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008136 276.0
TLS2_k127_2678379_2 Dihaem cytochrome c - - - 0.0000000000000000000000000000009749 123.0
TLS2_k127_2697393_0 Sulfite reductase K00381,K00392 - 1.8.1.2,1.8.7.1 2.379e-283 880.0
TLS2_k127_2697393_1 Bacterial protein of unknown function (DUF934) - - - 0.0000000000000000000000000000000000004155 145.0
TLS2_k127_2697393_2 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000181 98.0
TLS2_k127_2704329_0 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 519.0
TLS2_k127_2704329_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 322.0
TLS2_k127_2740811_0 Protein of unknown function (DUF1631) - - - 0.0 1139.0
TLS2_k127_2740811_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 3.442e-251 789.0
TLS2_k127_2740811_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007003 539.0
TLS2_k127_2740811_3 Belongs to the Smg family K03747 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007804 251.0
TLS2_k127_2748373_0 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 300.0
TLS2_k127_2748373_1 cell septum assembly - - - 0.00000000000000000000000000000000000000000000000000003144 192.0
TLS2_k127_2748373_2 AAA domain - - - 0.000000000000000000000000000000000000000000002426 170.0
TLS2_k127_2748373_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0000000000000000000000000000000306 129.0
TLS2_k127_2748373_4 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000000000000001484 121.0
TLS2_k127_2782204_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.081e-261 811.0
TLS2_k127_2782204_1 Thioredoxin K03672 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000005523 225.0
TLS2_k127_2787732_0 Belongs to the GARS family K01945 - 6.3.4.13 2.703e-201 638.0
TLS2_k127_2787732_1 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 505.0
TLS2_k127_2787732_2 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000003799 219.0
TLS2_k127_2787732_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000008429 188.0
TLS2_k127_2787732_4 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000007249 166.0
TLS2_k127_2821491_0 RNB K01147 - 3.1.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 409.0
TLS2_k127_2821491_1 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 388.0
TLS2_k127_2827461_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 8.169e-221 707.0
TLS2_k127_2827461_1 Protein of unknown function (DUF3014) - - - 0.0000000000000000000000000000000000000000000000000000000000644 216.0
TLS2_k127_2827461_2 NapC/NirT cytochrome c family, N-terminal region K15876 - - 0.00000000000000000000000000000000000000000000000000000005434 205.0
TLS2_k127_2827461_3 Belongs to the DapA family K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000008018 165.0
TLS2_k127_2827461_4 transcriptional regulator, Rrf2 family K13771 - - 0.0000000000002922 72.0
TLS2_k127_2827550_0 outer membrane cobalamin receptor K02014,K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 441.0
TLS2_k127_2827550_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 333.0
TLS2_k127_2827550_2 Periplasmic binding protein K02016,K06858 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 295.0
TLS2_k127_2827550_3 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000002626 264.0
TLS2_k127_2832604_0 Fic/DOC family N-terminal - - - 7.702e-206 645.0
TLS2_k127_2832604_1 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity K03583 - 3.1.11.5 0.00000000000000000000000000000000000000000000000000003846 191.0
TLS2_k127_2832604_2 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000004298 147.0
TLS2_k127_2832604_3 oxidoreductase FAD NAD(P)-binding domain protein K03863 - - 0.0000000000000000000000005533 109.0
TLS2_k127_2832604_4 Type III restriction - - - 0.0006157 48.0
TLS2_k127_2832965_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 8.499e-316 988.0
TLS2_k127_2832965_1 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 7.796e-315 971.0
TLS2_k127_2832965_10 dehydrogenase K00253 - 1.3.8.4 0.0001945 46.0
TLS2_k127_2832965_2 PFAM acyl-CoA dehydrogenase domain protein K00253 - 1.3.8.4 1.236e-235 731.0
TLS2_k127_2832965_3 Belongs to the thiolase family K00626 - 2.3.1.9 5.749e-199 629.0
TLS2_k127_2832965_4 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 385.0
TLS2_k127_2832965_5 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 365.0
TLS2_k127_2832965_6 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 353.0
TLS2_k127_2832965_7 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 286.0
TLS2_k127_2832965_8 D,D-heptose 1,7-bisphosphate phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000268 279.0
TLS2_k127_2832965_9 Lysine exporter protein LysE K11250 - - 0.000000000000000000000000000000000000000000000000566 184.0
TLS2_k127_2841369_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00244 - 1.3.5.4 2.37e-264 823.0
TLS2_k127_2841369_1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004577 453.0
TLS2_k127_2841369_2 TIGRFAM Succinate dehydrogenase fumarate reductase iron-sulphur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 383.0
TLS2_k127_2850693_0 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0 1080.0
TLS2_k127_2850693_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 509.0
TLS2_k127_2850693_2 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 492.0
TLS2_k127_2850693_3 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 462.0
TLS2_k127_2850693_4 PFAM Cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 359.0
TLS2_k127_285508_0 Transporter - - - 9.982e-314 973.0
TLS2_k127_285508_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 2.009e-272 850.0
TLS2_k127_285508_2 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008182 471.0
TLS2_k127_285508_3 Domain of unknown function (DUF1850) - - - 0.000000000000000000000000000001388 127.0
TLS2_k127_2870355_0 PFAM MotA TolQ ExbB proton channel K03561,K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 374.0
TLS2_k127_2870355_1 PFAM thioesterase superfamily protein K07107 - - 0.0000000000000000000000000000000000000000000000000002793 187.0
TLS2_k127_2870355_2 Biopolymer transport protein ExbD TolR K03560 - - 0.000000000000000000000000000000000000000000000000005676 190.0
TLS2_k127_2870355_3 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000000000000000000000000009329 143.0
TLS2_k127_2870355_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000008496 91.0
TLS2_k127_2870355_5 TonB C terminal K03646 - - 0.0000003267 55.0
TLS2_k127_2880128_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1091.0
TLS2_k127_2880128_1 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009802 434.0
TLS2_k127_2881052_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 492.0
TLS2_k127_2881052_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 481.0
TLS2_k127_2881052_2 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000809 83.0
TLS2_k127_2881052_3 Insulinase (Peptidase family M16) K07263 - - 0.000006107 49.0
TLS2_k127_2886109_0 NAD(P)H quinone oxidoreductase, PIG3 family K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 496.0
TLS2_k127_2886109_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 414.0
TLS2_k127_2886109_2 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000008132 138.0
TLS2_k127_2886109_3 PFAM Preprotein translocase SecG subunit K03075 - - 0.0000000007188 60.0
TLS2_k127_2895309_0 AMP-binding enzyme - - - 8.395e-268 832.0
TLS2_k127_2895309_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 319.0
TLS2_k127_2895309_2 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000111 234.0
TLS2_k127_2895309_3 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000005172 233.0
TLS2_k127_2895309_4 Glycosyltransferase like family 2 K20444 - - 0.0000000000000000000000000000000000000000000000000000001155 207.0
TLS2_k127_2895309_5 Phosphopantetheine attachment site - - - 0.00000000000000000000000000004094 123.0
TLS2_k127_290600_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 5.998e-208 652.0
TLS2_k127_290600_1 Glycosyltransferase like family 2 K20444 - - 0.000000003503 60.0
TLS2_k127_2911642_0 Cytochrome c oxidase subunit K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 482.0
TLS2_k127_2911642_1 SURF1-like protein K14998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002698 265.0
TLS2_k127_2911642_2 signal sequence binding - - - 0.00000000000000000000001561 106.0
TLS2_k127_2915324_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1140.0
TLS2_k127_2915324_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1063.0
TLS2_k127_2915324_2 Peptidase family M3 K01392 - 3.4.24.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 616.0
TLS2_k127_2915324_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003723 276.0
TLS2_k127_2915336_0 PFAM acyl-CoA dehydrogenase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 521.0
TLS2_k127_2915336_1 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 508.0
TLS2_k127_2915336_2 PFAM peptidase S58 DmpA K01266 - 3.4.11.19 0.0000000000000000000000000000000002546 136.0
TLS2_k127_2917357_0 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 388.0
TLS2_k127_2917357_1 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 288.0
TLS2_k127_2917357_2 Rhodanese-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000001647 225.0
TLS2_k127_2917357_3 Belongs to the UPF0225 family K09858 - - 0.000000000000000000000000000000000000000000000000009337 190.0
TLS2_k127_2941672_0 Protein of unknown function (DUF3179) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 324.0
TLS2_k127_2941672_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 GO:0003674,GO:0003824,GO:0004362,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0022900,GO:0031974,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0098869,GO:1901360,GO:1990748 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000008534 239.0
TLS2_k127_2941672_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000007632 156.0
TLS2_k127_2941672_3 Putative zinc-finger - - - 0.00001123 50.0
TLS2_k127_2946062_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 595.0
TLS2_k127_2946062_1 lytic transglycosylase K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 594.0
TLS2_k127_2946062_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 440.0
TLS2_k127_2946062_3 Domain of unknown function (DUF1993) K09983 - - 0.000000000000000000000000000000000000000000000000000000000000000001325 231.0
TLS2_k127_2946062_4 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000002428 214.0
TLS2_k127_2946062_5 chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000004557 193.0
TLS2_k127_2946062_6 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.000000000000000000000005224 101.0
TLS2_k127_2953074_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.78e-246 776.0
TLS2_k127_2953074_1 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005029 518.0
TLS2_k127_2953074_2 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 497.0
TLS2_k127_2953074_3 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005123 433.0
TLS2_k127_2964253_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 4.512e-194 626.0
TLS2_k127_2964253_1 Lytic murein transglycosylase B K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 444.0
TLS2_k127_2964253_2 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 398.0
TLS2_k127_2968456_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 568.0
TLS2_k127_2968456_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 381.0
TLS2_k127_2971629_0 FtsX-like permease family K02004 - - 0.0 1110.0
TLS2_k127_2971629_1 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K21053 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 544.0
TLS2_k127_2971629_2 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 413.0
TLS2_k127_2971629_3 chemotaxis protein K03406 - - 0.000000006172 61.0
TLS2_k127_297812_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 1.729e-247 766.0
TLS2_k127_297812_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 419.0
TLS2_k127_297812_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005347 411.0
TLS2_k127_297812_3 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000006295 227.0
TLS2_k127_2988483_0 Carbamoyl-phosphate synthase L chain, ATP-binding K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 408.0
TLS2_k127_2988483_1 enoyl-CoA hydratase K13766,K15312 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 402.0
TLS2_k127_2988483_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000261 212.0
TLS2_k127_2992322_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 379.0
TLS2_k127_2992322_1 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 326.0
TLS2_k127_2992322_10 - - - - 0.000000000004048 67.0
TLS2_k127_2992322_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 326.0
TLS2_k127_2992322_3 Glycosyl transferase K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006229 276.0
TLS2_k127_2992322_4 EVE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001425 226.0
TLS2_k127_2992322_5 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000000000000000000000000003681 220.0
TLS2_k127_2992322_6 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000004219 174.0
TLS2_k127_2992322_7 Putative phosphatase (DUF442) - - - 0.0000000000000000000000000000000000000000000001262 177.0
TLS2_k127_2992322_8 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000000000000000000000003274 139.0
TLS2_k127_2992322_9 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000000000002241 134.0
TLS2_k127_3006175_0 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 441.0
TLS2_k127_3006175_1 40-residue YVTN family beta-propeller repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006643 428.0
TLS2_k127_3006175_2 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000005664 124.0
TLS2_k127_3008393_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 9.727e-212 664.0
TLS2_k127_3008393_1 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 1.538e-201 640.0
TLS2_k127_3008393_10 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000000000002207 169.0
TLS2_k127_3008393_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000002704 126.0
TLS2_k127_3008393_12 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.000000000000000000000002261 108.0
TLS2_k127_3008393_2 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 3.886e-199 637.0
TLS2_k127_3008393_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 571.0
TLS2_k127_3008393_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008632 303.0
TLS2_k127_3008393_5 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005469 272.0
TLS2_k127_3008393_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K02573 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000126 279.0
TLS2_k127_3008393_7 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000001681 227.0
TLS2_k127_3008393_8 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000001841 221.0
TLS2_k127_3008393_9 NADH dehydrogenase (ubiquinone) activity K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.000000000000000000000000000000000000000000000964 171.0
TLS2_k127_3011650_0 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 357.0
TLS2_k127_3011650_1 GTP cyclohydrolase N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 344.0
TLS2_k127_3011650_2 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 294.0
TLS2_k127_3022593_0 modulator of DNA gyrase K03592 - - 4.69e-230 719.0
TLS2_k127_3022593_1 serine O-acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 434.0
TLS2_k127_3022593_2 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 362.0
TLS2_k127_3022593_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006533 349.0
TLS2_k127_3022593_4 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007303 319.0
TLS2_k127_3022593_5 molybdenum cofactor K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 322.0
TLS2_k127_3022593_6 Belongs to the UPF0307 family K09889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006649 250.0
TLS2_k127_3029098_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 5.386e-270 840.0
TLS2_k127_3029098_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 5.715e-247 767.0
TLS2_k127_3029098_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 8.803e-225 706.0
TLS2_k127_3043245_0 Proton-conducting membrane transporter - - - 0.0 1154.0
TLS2_k127_3043245_1 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 576.0
TLS2_k127_3043245_2 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 548.0
TLS2_k127_3043245_3 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000006475 263.0
TLS2_k127_3043245_4 major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000009043 227.0
TLS2_k127_3043245_5 Transcriptional regulator K03892 - - 0.000000000000000000000000000000000000000001944 157.0
TLS2_k127_3043245_6 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000003003 175.0
TLS2_k127_3043245_7 Thioredoxin domain - - - 0.000000000000000000000000000002373 128.0
TLS2_k127_3043245_8 Ribbon-helix-helix protein, copG family - - - 0.00000000000000000000007746 100.0
TLS2_k127_3049113_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000001419 191.0
TLS2_k127_3053234_0 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008328 466.0
TLS2_k127_3053234_1 PFAM Cyclopropane-fatty-acyl-phospholipid synthase K00574 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009907 389.0
TLS2_k127_3053328_0 Prolyl oligopeptidase K01322 - 3.4.21.26 0.0 1053.0
TLS2_k127_3053328_1 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 420.0
TLS2_k127_3053328_2 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 346.0
TLS2_k127_3053328_3 YaeQ - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001778 252.0
TLS2_k127_3053328_4 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0001475 44.0
TLS2_k127_3060692_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 412.0
TLS2_k127_3060692_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 349.0
TLS2_k127_3060692_2 peptidase K06194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 346.0
TLS2_k127_3060692_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000003772 235.0
TLS2_k127_3070253_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0 1034.0
TLS2_k127_3070253_1 transcriptional regulator K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005378 532.0
TLS2_k127_3070253_2 PFAM Dehydrogenase, E1 component K00166 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 512.0
TLS2_k127_3075159_0 PFAM SNF2-related protein - - - 4.93e-262 823.0
TLS2_k127_3075159_1 ORF6N domain - - - 0.00000000000000000000000000001285 122.0
TLS2_k127_3084886_0 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 574.0
TLS2_k127_3084886_1 LysM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008691 518.0
TLS2_k127_3084886_2 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 437.0
TLS2_k127_3084886_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 425.0
TLS2_k127_3084886_4 branched-chain amino acid permease (azaleucine resistance) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 310.0
TLS2_k127_3084886_5 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000005676 262.0
TLS2_k127_3084886_6 PFAM branched-chain amino acid transport - - - 0.000000000000000000000000000000000000006759 159.0
TLS2_k127_3084886_7 Putative auto-transporter adhesin, head GIN domain - - - 0.000000000000000000000000000000000001893 150.0
TLS2_k127_3084886_8 - - - - 0.000000000000000000000000000007258 125.0
TLS2_k127_3086375_0 PFAM aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0 998.0
TLS2_k127_3086375_1 FAD-dependent pyridine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 324.0
TLS2_k127_309402_0 May be involved in recombination K03554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007006 411.0
TLS2_k127_309402_1 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000001161 204.0
TLS2_k127_3118492_0 AAA ATPase, central domain protein - - - 1.112e-211 664.0
TLS2_k127_3118492_1 PFAM Rieske 2Fe-2S domain protein K03862,K18068 - 1.14.12.7,1.14.13.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 520.0
TLS2_k127_3118492_2 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000000000000006877 194.0
TLS2_k127_3137850_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein K07303 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 524.0
TLS2_k127_3137850_1 2Fe-2S -binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001974 277.0
TLS2_k127_3137850_2 AraC-type transcriptional regulator N-terminus - - - 0.000001146 56.0
TLS2_k127_3143646_0 Histidine kinase-like ATPases - - - 3.789e-206 676.0
TLS2_k127_3143646_1 Two component transcriptional regulator K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 375.0
TLS2_k127_3143646_2 PFAM OmpW family protein K07275 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 289.0
TLS2_k127_3150973_0 Diguanylate cyclase - - - 1.535e-266 853.0
TLS2_k127_3150973_1 chemotaxis K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005134 397.0
TLS2_k127_3150973_2 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000000000000005029 182.0
TLS2_k127_3150973_3 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000000000000000000000000000008288 173.0
TLS2_k127_3150973_4 Penicillinase repressor - - - 0.0000000000000000000000000000000000000004073 151.0
TLS2_k127_3150973_5 Transcriptional regulator - - - 0.0000000000000000000000000000002417 134.0
TLS2_k127_3182616_0 TIGRFAM type I secretion outer membrane protein, TolC family K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009807 444.0
TLS2_k127_3182616_1 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003664 331.0
TLS2_k127_3182616_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000417 275.0
TLS2_k127_3182616_3 Bacterial transcriptional repressor C-terminal K09017 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002344 261.0
TLS2_k127_3186286_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 2.807e-233 734.0
TLS2_k127_3186286_1 HAD-superfamily hydrolase, subfamily IB, PSPase-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 316.0
TLS2_k127_3186286_2 Belongs to the DnaA family K10763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002342 252.0
TLS2_k127_3186286_3 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000006622 194.0
TLS2_k127_3193568_0 Signal transducing histidine kinase, homodimeric domain K02487,K06596 - - 0.0 1427.0
TLS2_k127_3193568_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000001415 189.0
TLS2_k127_3202856_0 MotA/TolQ/ExbB proton channel family K02556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 499.0
TLS2_k127_3202856_1 Membrane MotB of proton-channel complex MotA/MotB K02557 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005112 455.0
TLS2_k127_3202856_2 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) K03414 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 348.0
TLS2_k127_3202856_3 Response regulator receiver K03413 - - 0.000000000000000000000000000000000000000000000000000000000000000000001762 239.0
TLS2_k127_3202856_4 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.000000000000000000000000000000000000000000000000000002083 198.0
TLS2_k127_3202856_5 methyltransferase - - - 0.00000000000000000000000000000000131 132.0
TLS2_k127_3222427_0 Carboxyl transferase domain K01969 - 6.4.1.4 1.265e-309 954.0
TLS2_k127_3222427_1 TrkA-C domain K03499 - - 1.246e-228 715.0
TLS2_k127_3222427_2 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 5e-212 678.0
TLS2_k127_3222427_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000000000000001026 178.0
TLS2_k127_3222427_4 Bacterial antitoxin of type II TA system, VapB - - - 0.0000000000000001333 83.0
TLS2_k127_3222427_5 Domain of unknown function (DUF3482) - - - 0.00000000001515 68.0
TLS2_k127_3228887_0 Belongs to the methyltransferase superfamily K07444 - - 2.141e-201 635.0
TLS2_k127_3228887_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 7.925e-196 618.0
TLS2_k127_3240992_0 protease with the C-terminal PDZ domain - - - 3.267e-210 670.0
TLS2_k127_3244929_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 0.0 1090.0
TLS2_k127_3244929_1 Large family of predicted nucleotide-binding domains K07175 - - 3.288e-305 943.0
TLS2_k127_3244929_2 alcohol dehydrogenase K19745 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 507.0
TLS2_k127_3244929_3 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 282.0
TLS2_k127_3244929_4 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K03829 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 - 0.000000000000000000000000000000000000000000000000000000000000000005602 229.0
TLS2_k127_3244929_6 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000004435 67.0
TLS2_k127_3252273_0 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 484.0
TLS2_k127_3252273_1 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000003814 247.0
TLS2_k127_3252273_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000001156 147.0
TLS2_k127_3252273_3 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.000000000000000000000003263 102.0
TLS2_k127_3252273_4 SnoaL-like domain - - - 0.000000000002921 77.0
TLS2_k127_3253243_0 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway K00351 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 503.0
TLS2_k127_3253243_1 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004225 483.0
TLS2_k127_3253243_2 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00349 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001555 282.0
TLS2_k127_3253243_3 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00350 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000004021 276.0
TLS2_k127_3253243_4 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00348 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000001625 230.0
TLS2_k127_3253243_5 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 0.000000000000000000000000000000001698 130.0
TLS2_k127_3255558_0 Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 452.0
TLS2_k127_3255558_1 PFAM peptidase S10 serine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 350.0
TLS2_k127_3255558_2 2OG-Fe dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 348.0
TLS2_k127_3255558_3 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007562 287.0
TLS2_k127_3255558_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004263 233.0
TLS2_k127_3259981_0 Tryptophan halogenase K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 552.0
TLS2_k127_3259981_1 Glutamine amido-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 442.0
TLS2_k127_3259981_2 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 411.0
TLS2_k127_3259981_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000002346 135.0
TLS2_k127_33003_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 6.928e-209 655.0
TLS2_k127_33003_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 389.0
TLS2_k127_33003_2 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003265 270.0
TLS2_k127_3304353_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0 1097.0
TLS2_k127_3304353_1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 599.0
TLS2_k127_3304353_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000004162 141.0
TLS2_k127_3304353_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00001554 50.0
TLS2_k127_3308083_0 Methylenetetrahydrofolate reductase K00297 GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006506 380.0
TLS2_k127_3308083_1 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 320.0
TLS2_k127_3308083_2 OmpW family K07275 - - 0.000000000000000000000000000000000000000000000000000000000005648 214.0
TLS2_k127_3308083_3 TfoX N-terminal domain K07343 - - 0.000000000000000000000000000001029 133.0
TLS2_k127_3312806_0 PFAM peptidase M16 domain protein K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 562.0
TLS2_k127_3312806_1 PFAM peptidase M16 domain protein K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 563.0
TLS2_k127_3312806_2 PFAM NUDIX hydrolase K07455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 445.0
TLS2_k127_3312806_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000001232 73.0
TLS2_k127_3315789_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 512.0
TLS2_k127_3315789_1 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 357.0
TLS2_k127_3315789_2 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003615 274.0
TLS2_k127_3316383_0 FAD linked oxidase domain protein - - - 1.982e-272 843.0
TLS2_k127_3316383_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 522.0
TLS2_k127_3316383_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000878 402.0
TLS2_k127_3316383_3 PPIC-type PPIASE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 344.0
TLS2_k127_3316383_4 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008994 299.0
TLS2_k127_3316383_5 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003882 276.0
TLS2_k127_3316383_6 Protein of unknown function (DUF971) - - - 0.000000000000000000000000000000000000000000000000000000000000001706 222.0
TLS2_k127_3316383_7 Cold shock protein K03704 - - 0.0000000000000000000000000009858 114.0
TLS2_k127_3327967_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 1.949e-270 839.0
TLS2_k127_3327967_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000947 524.0
TLS2_k127_3327967_2 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001302 249.0
TLS2_k127_3327967_3 Belongs to the transcriptional regulatory Fis family K03557 - - 0.00000000000000000000000000001498 121.0
TLS2_k127_3327967_4 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.000000000000000000000008472 111.0
TLS2_k127_3328830_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0 1022.0
TLS2_k127_3328830_1 regulator K07684 - - 0.00000000000000000000000000000000000000000000000000000000000000000000289 238.0
TLS2_k127_3328830_2 Domain of unknown function (DUF4212) - - - 0.0000000000000000000000000000000000005218 146.0
TLS2_k127_3328830_3 Histidine kinase K07673 - 2.7.13.3 0.00000000000232 67.0
TLS2_k127_3328830_4 Bacterial regulatory proteins, luxR family K07684 - - 0.000000001394 62.0
TLS2_k127_3328830_5 ribonuclease BN K07058 - - 0.000001933 52.0
TLS2_k127_3336635_0 Cysteine-rich domain - - - 8.726e-239 745.0
TLS2_k127_3336635_1 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007583 276.0
TLS2_k127_3336635_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000001355 158.0
TLS2_k127_3343881_0 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 456.0
TLS2_k127_3343881_1 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002671 261.0
TLS2_k127_3343881_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000001918 174.0
TLS2_k127_3343881_3 TIGRFAM A G-specific adenine glycosylase K03575 - - 0.000000000000000000000004912 104.0
TLS2_k127_3382698_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 575.0
TLS2_k127_3382698_1 helix-turn-helix- domain containing protein, AraC type K13529 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009295 462.0
TLS2_k127_3401380_0 Polysaccharide biosynthesis protein - - - 3.026e-288 897.0
TLS2_k127_3401380_1 Domain of unknown function (DUF4143) K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 438.0
TLS2_k127_3401380_2 Sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 292.0
TLS2_k127_340392_0 major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 453.0
TLS2_k127_340392_1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 441.0
TLS2_k127_340392_2 Domain of unknown function (DUF4113) K03502 - - 0.00000000000000000000000000000000001487 139.0
TLS2_k127_340392_3 Peptidase S24-like K03503 - - 0.0000000000000000000000000000000007627 136.0
TLS2_k127_3405870_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 4.13e-205 640.0
TLS2_k127_3405870_1 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 546.0
TLS2_k127_3405870_2 ABC-type Fe3 transport system, permease component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 376.0
TLS2_k127_3405870_3 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 339.0
TLS2_k127_3405870_4 uroporphyrinogen-III synthase activity K01719,K01749,K02496,K13542,K13543 GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.0001527 46.0
TLS2_k127_3445561_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 8.219e-262 824.0
TLS2_k127_3445561_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 560.0
TLS2_k127_3445561_2 PFAM FeoA family protein K04758 - - 0.0000000000000000000001601 100.0
TLS2_k127_3466197_0 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 0.0 2041.0
TLS2_k127_3466197_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000001837 184.0
TLS2_k127_3469172_0 chemotaxis sensory transducer K03406,K03776,K05874 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 419.0
TLS2_k127_3469172_1 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein K05796 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 328.0
TLS2_k127_3469172_2 phospholipase K01058 - 3.1.1.32,3.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 310.0
TLS2_k127_3469172_3 Two component signalling adaptor domain K03408 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002314 243.0
TLS2_k127_3469172_4 PFAM aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000007436 214.0
TLS2_k127_3480524_0 PGAP1-like protein - - - 8.333e-224 706.0
TLS2_k127_3480524_1 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001058 254.0
TLS2_k127_3480524_2 Cache domain - - - 0.000000000000000000000000000000000000000000004814 168.0
TLS2_k127_3480524_3 Protein of unknown function (DUF454) K09790 - - 0.0000000000000000000000000000000000000003047 158.0
TLS2_k127_3480524_4 - - - - 0.000000000000000000000000000000002097 133.0
TLS2_k127_3480524_5 Nitrous oxide-stimulated promoter - - - 0.000000000000000000000000000000003941 133.0
TLS2_k127_3480524_7 - - - - 0.0001056 49.0
TLS2_k127_3506606_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 2.677e-261 811.0
TLS2_k127_3506606_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 312.0
TLS2_k127_3506606_2 Domain of unknown function (DUF1924) - - - 0.000000000000000000000000000000000000000000001163 170.0
TLS2_k127_3506606_3 - - - - 0.000000000000000000000000000000000000000007922 158.0
TLS2_k127_3506606_4 PFAM SlyX family protein K03745 - - 0.00000000000000001139 87.0
TLS2_k127_3506606_5 Dihaem cytochrome c - - - 0.000000000001398 71.0
TLS2_k127_3506735_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 455.0
TLS2_k127_3506735_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000911 308.0
TLS2_k127_3506735_2 Phosphoglycerate mutase family K15634 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000004521 259.0
TLS2_k127_3506735_3 dioxygenase of extradiol dioxygenase family K06991 - - 0.00000000000000000000000000000000000000000000000000000000000000000008872 234.0
TLS2_k127_3506735_4 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000001644 174.0
TLS2_k127_3522554_0 PFAM FAD linked oxidase domain protein K00102,K00104,K03777 - 1.1.2.4,1.1.3.15,1.1.5.12 9.078e-271 839.0
TLS2_k127_3522554_1 Vitamin B12 dependent methionine synthase activation region K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009849 271.0
TLS2_k127_3522554_2 PFAM FAD linked oxidase domain protein K11472 - - 0.00000000000000000000000000000000000000000000000006399 179.0
TLS2_k127_3528342_0 Putative diguanylate phosphodiesterase - - - 1.184e-248 785.0
TLS2_k127_3528342_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004908 446.0
TLS2_k127_3528342_2 Phosphatidylserine decarboxylase K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 382.0
TLS2_k127_3528342_3 Pyridoxamine 5'-phosphate oxidase-related, FMN binding protein K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002355 275.0
TLS2_k127_3528342_4 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000117 259.0
TLS2_k127_3528342_5 PFAM regulatory protein TetR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006296 247.0
TLS2_k127_3528342_6 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003864 239.0
TLS2_k127_3528342_7 DsrE/DsrF-like family - - - 0.0000000000000000000000000000000000000000000000000000000000001465 214.0
TLS2_k127_3528342_8 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000332 104.0
TLS2_k127_3542936_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 524.0
TLS2_k127_3542936_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 511.0
TLS2_k127_3542936_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772,K03815 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 460.0
TLS2_k127_3542936_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007064 410.0
TLS2_k127_3542936_4 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002369 287.0
TLS2_k127_3542936_5 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000001691 165.0
TLS2_k127_3542936_6 Aldehyde dehydrogenase family K00130,K09472,K12254 - 1.2.1.54,1.2.1.8,1.2.1.99 0.000000000000000000001884 93.0
TLS2_k127_3550321_0 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons K01026 - 2.8.3.1 1.402e-281 879.0
TLS2_k127_3550321_1 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006519 389.0
TLS2_k127_3550321_2 peptidase dimerisation domain protein K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 349.0
TLS2_k127_3550321_3 Protein of unknown function (DUF962) - - - 0.000000000000000001488 87.0
TLS2_k127_3552710_0 Iron-containing alcohol dehydrogenase K00043,K00217 - 1.1.1.61,1.3.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 391.0
TLS2_k127_3552710_1 abc transporter atp-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009054 282.0
TLS2_k127_3552710_2 Endoribonuclease L-PSP K09021 - - 0.00000000000000000000000000000000000000000000076 179.0
TLS2_k127_3552710_3 GntR family transcriptional regulator K07979 - - 0.000000000000000000000000000000113 128.0
TLS2_k127_3552710_4 - K01992 - - 0.00000001058 66.0
TLS2_k127_3552883_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07789 - - 0.0 1249.0
TLS2_k127_3552883_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 414.0
TLS2_k127_3552883_2 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000001036 190.0
TLS2_k127_3553125_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 539.0
TLS2_k127_3553125_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007746 450.0
TLS2_k127_3553125_2 Bacterial extracellular solute-binding proteins, family 3 - - - 0.000000000000000000000000000000000000000000000000000000000000002083 224.0
TLS2_k127_3553125_3 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000001353 168.0
TLS2_k127_3561830_0 Alpha-amylase domain K00705 - 2.4.1.25 4.014e-265 841.0
TLS2_k127_3561830_1 TIGRFAM TRAP dicarboxylate transporter, DctP subunit K21395 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 464.0
TLS2_k127_3561830_2 Involved in chromosome partitioning - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007376 302.0
TLS2_k127_3564289_0 Succinyl-CoA ligase like flavodoxin domain K09181 - - 0.0 1234.0
TLS2_k127_3564289_1 2-dehydropantoate 2-reductase K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 443.0
TLS2_k127_3564289_2 Protein of unknown function (DUF1415) K09941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003301 259.0
TLS2_k127_3564289_3 Putative esterase - - - 0.00000000000000000000000000000000009514 145.0
TLS2_k127_3564289_4 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000005411 143.0
TLS2_k127_3564289_6 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000793 93.0
TLS2_k127_3564289_7 - - - - 0.00007058 50.0
TLS2_k127_3570129_0 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 3.829e-317 975.0
TLS2_k127_3570129_1 - - - - 0.00000000000000000000000000000001085 129.0
TLS2_k127_3570129_2 - - - - 0.000000000000000002584 90.0
TLS2_k127_3584094_0 Uroporphyrin-iii c tetrapyrrole (Corrin porphyrin) methyltransferase K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423 355.0
TLS2_k127_3584094_1 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 305.0
TLS2_k127_3584094_2 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000000000000000000002607 169.0
TLS2_k127_3584094_3 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000000000000001736 124.0
TLS2_k127_3584094_4 Belongs to the DEAD box helicase family K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.0000000003744 61.0
TLS2_k127_3591126_0 CHASE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 445.0
TLS2_k127_3591126_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000009032 222.0
TLS2_k127_3598119_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 584.0
TLS2_k127_3598119_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 499.0
TLS2_k127_3600791_0 HELICc2 K03722 - 3.6.4.12 6.032e-311 974.0
TLS2_k127_3600791_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 420.0
TLS2_k127_3600791_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 350.0
TLS2_k127_3600791_3 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007798 321.0
TLS2_k127_3600791_4 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000001661 193.0
TLS2_k127_3600791_5 Protein of unknown function (DUF465) - - - 0.0000000000000000000001066 100.0
TLS2_k127_3609381_0 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000001294 197.0
TLS2_k127_3609381_1 - K07112 - - 0.000000000000000000000000000000000000000001965 161.0
TLS2_k127_3609381_2 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K00406,K01011,K07112 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000005256 168.0
TLS2_k127_3609381_3 Metal-sensitive transcriptional repressor - - - 0.0000000000000000000000000000000001836 134.0
TLS2_k127_3610158_0 Bacterial protein of unknown function (DUF839) K07093 - - 2.704e-248 773.0
TLS2_k127_3610158_1 PEP-CTERM motif - - - 0.00000000000000001494 89.0
TLS2_k127_3612227_0 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006481 607.0
TLS2_k127_3612227_1 Iron-containing alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 404.0
TLS2_k127_361564_0 'PFAM Alpha amylase, catalytic K00690 GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006066,GO:0006073,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016757,GO:0019400,GO:0019751,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0051472,GO:0071704,GO:1901615 2.4.1.7 1.637e-222 714.0
TLS2_k127_361564_1 Major Facilitator Superfamily K16211 - - 4.148e-201 638.0
TLS2_k127_361564_2 TonB-dependent Receptor Plug Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 589.0
TLS2_k127_361564_3 pfkB family carbohydrate kinase K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000003487 207.0
TLS2_k127_361564_4 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0000000000000000000000007279 106.0
TLS2_k127_3617116_0 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009389 562.0
TLS2_k127_3617116_1 Protein of unknown function (DUF808) K09781 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 387.0
TLS2_k127_3617116_2 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000000004012 109.0
TLS2_k127_3617116_3 - - - - 0.000000000000000000006109 94.0
TLS2_k127_3617116_4 PAP2 superfamily - - - 0.000000000009499 67.0
TLS2_k127_362859_0 Alkylhydroperoxidase AhpD family core domain-containing protein 7 - - - 0.000000000000000000000000000000000000000000000000000000000002441 219.0
TLS2_k127_362859_1 Uncharacterised protein family (UPF0149) K07039 - - 0.0000000000000000000000000000000000002743 151.0
TLS2_k127_362859_2 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406,K05874 - - 0.000000000000000007135 93.0
TLS2_k127_362859_3 S4 domain K14761 - - 0.00000000000000001425 84.0
TLS2_k127_3643195_0 Flavin containing amine oxidoreductase K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 344.0
TLS2_k127_3643195_1 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000001185 160.0
TLS2_k127_3648445_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 0.0 1074.0
TLS2_k127_3648445_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 5.776e-266 821.0
TLS2_k127_3648445_2 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 459.0
TLS2_k127_3648445_3 UTRA K03710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009607 338.0
TLS2_k127_3648445_4 TIGRFAM Succinate dehydrogenase, hydrophobic membrane anchor K00242 - - 0.000000000000000000000000000000000000000000000000000000000005633 210.0
TLS2_k127_3648445_5 Succinate dehydrogenase cytochrome b556 subunit K00241 - - 0.0000000000000000000000000000000000000000000000000000000002747 206.0
TLS2_k127_3648445_6 NlpB/DapX lipoprotein K07287 - - 0.0000000000000000000000000000000000009098 141.0
TLS2_k127_3648445_7 Flavinator of succinate dehydrogenase K09159 - - 0.000000000000000000000000000000005295 130.0
TLS2_k127_3657639_0 NMT1-like family K02051,K15576,K22067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 308.0
TLS2_k127_3657639_1 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 302.0
TLS2_k127_3669083_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 6.654e-254 792.0
TLS2_k127_3669083_1 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 299.0
TLS2_k127_3669083_10 Ribosomal protein L30 K02907 - - 0.0000000000000000000002164 97.0
TLS2_k127_3669083_11 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000001498 77.0
TLS2_k127_3669083_12 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0001242 44.0
TLS2_k127_3669083_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 301.0
TLS2_k127_3669083_3 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001346 263.0
TLS2_k127_3669083_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002109 239.0
TLS2_k127_3669083_5 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000000000000000001281 228.0
TLS2_k127_3669083_6 binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000000000000000000000003553 226.0
TLS2_k127_3669083_7 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000002011 176.0
TLS2_k127_3669083_8 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000000000000000000000000003762 169.0
TLS2_k127_3669083_9 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000000005579 149.0
TLS2_k127_3672170_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004624 551.0
TLS2_k127_3672170_1 Phosphoglycerate mutase family K08296 - - 0.00000000000000000000000000000000000000000000000000000000000004832 230.0
TLS2_k127_3672170_2 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000002856 58.0
TLS2_k127_3678475_0 Helicase K03657 - 3.6.4.12 0.0 1253.0
TLS2_k127_3678475_1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides K00364 - 1.7.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 581.0
TLS2_k127_3678475_2 Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 313.0
TLS2_k127_3697115_0 - - - - 0.0000000000000000000000000000000000000000000000000000000002236 213.0
TLS2_k127_3697115_1 ABC transporter K15738 - - 0.0000000000000000000000000000000000000000000000003812 179.0
TLS2_k127_3697115_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000002932 148.0
TLS2_k127_3755090_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1604.0
TLS2_k127_3755090_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 5.801e-215 675.0
TLS2_k127_3755090_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 360.0
TLS2_k127_3779308_0 Ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1121.0
TLS2_k127_3779308_1 epimerase dehydratase K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 602.0
TLS2_k127_3779308_10 - - - - 0.0000000000000000000000000000000000000000000000000003818 194.0
TLS2_k127_3779308_12 Anaerobic ribonucleoside-triphosphate reductase - - - 0.000000000000000001162 90.0
TLS2_k127_3779308_2 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05591,K05592 GO:0000339,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003729,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006412,GO:0006413,GO:0006518,GO:0006725,GO:0006807,GO:0008026,GO:0008135,GO:0008150,GO:0008152,GO:0008186,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0010501,GO:0016070,GO:0016281,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0042623,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0060255,GO:0065007,GO:0070035,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 571.0
TLS2_k127_3779308_3 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007666 455.0
TLS2_k127_3779308_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 411.0
TLS2_k127_3779308_5 HPr kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 313.0
TLS2_k127_3779308_6 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000554 297.0
TLS2_k127_3779308_7 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 310.0
TLS2_k127_3779308_8 Nitroreductase family K09019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 283.0
TLS2_k127_3779308_9 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000004375 238.0
TLS2_k127_3780722_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1153.0
TLS2_k127_3780722_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 6.887e-234 727.0
TLS2_k127_3780722_2 PFAM Aminotransferase class I and II K00832 - 2.6.1.57 6.204e-202 635.0
TLS2_k127_3780722_3 Transcriptional regulator K13643 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 308.0
TLS2_k127_3780722_4 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001558 243.0
TLS2_k127_3780722_5 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000000000000000002211 212.0
TLS2_k127_3780722_6 Low molecular weight phosphotyrosine protein phosphatase K01104 GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 0.0000000000000000000000000000000000000000000000000000000000009856 215.0
TLS2_k127_3780722_7 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000000000000000000000000000000000000000000000000002549 193.0
TLS2_k127_3787342_0 Smr protein MutS2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001346 271.0
TLS2_k127_3787342_1 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006729 244.0
TLS2_k127_3787342_2 gag-polyprotein putative aspartyl protease K06985 - - 0.000000000000000000000000000000000000000007654 158.0
TLS2_k127_3790393_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 2.774e-198 625.0
TLS2_k127_3790393_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 3.004e-195 617.0
TLS2_k127_3790393_2 COG3170 Tfp pilus assembly protein FimV K08086 - - 0.00000000000000000000000000000000000000000000000001484 183.0
TLS2_k127_3790393_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000006028 92.0
TLS2_k127_3792354_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 2.738e-293 904.0
TLS2_k127_3792354_1 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 424.0
TLS2_k127_3792354_2 cytochrome C oxidase K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 367.0
TLS2_k127_3792354_3 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.00000000000000000001735 91.0
TLS2_k127_3792354_4 cytochrome oxidase maturation protein - - - 0.00000000000002027 77.0
TLS2_k127_3792354_5 Cbb3-type cytochrome oxidase K00407 - - 0.000000001448 60.0
TLS2_k127_3829869_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 9.759e-234 741.0
TLS2_k127_3829869_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 422.0
TLS2_k127_3829869_2 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000003908 110.0
TLS2_k127_3829869_3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.00000000000000000000004471 105.0
TLS2_k127_3837721_0 Threonine synthase K01733 - 4.2.3.1 1.454e-244 761.0
TLS2_k127_3837721_1 homoserine dehydrogenase K00003 - 1.1.1.3 3.265e-232 739.0
TLS2_k127_3837721_2 Molybdenum cofactor synthesis domain protein K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 599.0
TLS2_k127_3837721_3 PFAM aminotransferase, class I and II K14260 - 2.6.1.2,2.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 491.0
TLS2_k127_3837721_4 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000000000001032 105.0
TLS2_k127_3855403_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.209e-277 858.0
TLS2_k127_3855403_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 2.032e-208 655.0
TLS2_k127_3855403_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 351.0
TLS2_k127_3864546_0 Protein of unknown function (DUF3641) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 553.0
TLS2_k127_3864546_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000917 394.0
TLS2_k127_3864546_2 phosphonate ABC transporter, inner membrane subunit K02042 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001056 264.0
TLS2_k127_3864546_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000009884 204.0
TLS2_k127_3864546_5 Putative zinc-finger - - - 0.00000001377 61.0
TLS2_k127_3891105_0 Prolyl oligopeptidase family - - - 0.0 1137.0
TLS2_k127_3891105_1 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008874 528.0
TLS2_k127_3891105_2 VWA domain containing CoxE-like protein K09989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009585 494.0
TLS2_k127_3891105_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 314.0
TLS2_k127_3891105_4 Cytochrome c class I - - - 0.0000000000000000000000000000000000000000000000000000000000000000119 250.0
TLS2_k127_3891105_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000000000000000000000000001747 119.0
TLS2_k127_3891105_6 EamA-like transporter family - - - 0.0000000000000000000000001425 108.0
TLS2_k127_3891105_7 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.0000000000001637 75.0
TLS2_k127_3896987_0 RNA polymerase sigma factor RpoH K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 516.0
TLS2_k127_3896987_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 403.0
TLS2_k127_3896987_2 Electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000316 276.0
TLS2_k127_3896987_3 - - - - 0.000000000000000000005042 94.0
TLS2_k127_3896987_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000006282 71.0
TLS2_k127_3904824_0 sulfite reductase, dissimilatory-type alpha subunit K11180 - 1.8.99.5 7.519e-256 795.0
TLS2_k127_3904824_1 Nitrite and sulphite reductase 4Fe-4S domain K11181 - 1.8.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008938 514.0
TLS2_k127_3904824_2 - - - - 0.000000000000000000000005035 103.0
TLS2_k127_3926854_0 glutaminyl-tRNA synthetase K01886 - 6.1.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000715 566.0
TLS2_k127_3926854_1 cytochrome - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006217 267.0
TLS2_k127_3936826_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1157.0
TLS2_k127_3936826_1 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 604.0
TLS2_k127_3936826_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 575.0
TLS2_k127_3936826_3 Belongs to the skp family K06142 - - 0.00000000000000000000000000000000000000000000000000000000000000001414 229.0
TLS2_k127_3936826_4 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000005563 131.0
TLS2_k127_3936826_5 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000002092 109.0
TLS2_k127_3951001_0 ABC-2 family transporter protein K01992,K19341 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009284 401.0
TLS2_k127_3951001_1 NosL K19342 - - 0.000000000000000000000000000000000000000000000000000000001388 214.0
TLS2_k127_3951001_2 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000002661 199.0
TLS2_k127_3951001_3 NosL - - - 0.0000000000000000000000000000000000000000000000000261 197.0
TLS2_k127_3951001_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000006257 178.0
TLS2_k127_3951001_5 PFAM ABC transporter related K01990,K19340 - - 0.000000002535 59.0
TLS2_k127_3981484_0 LysR substrate binding domain K03717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 428.0
TLS2_k127_3981484_1 transcriptional regulator, Rrf2 family K13643 - - 0.00000000000000000000000000000000000003413 148.0
TLS2_k127_3981484_2 Histidine kinase - - - 0.000000004841 61.0
TLS2_k127_3986211_0 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 4.222e-201 634.0
TLS2_k127_3986211_1 PFAM 20S proteasome, A and B subunits K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000007411 265.0
TLS2_k127_4004805_0 Belongs to the glycosyl hydrolase 13 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 552.0
TLS2_k127_4004805_1 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 474.0
TLS2_k127_4010174_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1738.0
TLS2_k127_4010174_1 TIGRFAM Formate dehydrogenase, gamma subunit K00127 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 480.0
TLS2_k127_4010174_2 4Fe-4S dicluster domain K00124,K07307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 424.0
TLS2_k127_4010174_3 Translation elongation factor K03833 GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 399.0
TLS2_k127_4010174_4 - - - - 0.00000000000000000000002532 107.0
TLS2_k127_4010174_5 - - - - 0.0000000002569 73.0
TLS2_k127_4010174_6 - - - - 0.00000001472 59.0
TLS2_k127_40468_0 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 620.0
TLS2_k127_40468_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 524.0
TLS2_k127_40468_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 478.0
TLS2_k127_40468_3 D-isomer specific 2-hydroxyacid dehydrogenase K00090 - 1.1.1.215,1.1.1.79,1.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008765 481.0
TLS2_k127_40468_4 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 374.0
TLS2_k127_40468_5 TIGRFAM phasin family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002462 250.0
TLS2_k127_40468_6 Glutaredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000003843 234.0
TLS2_k127_40468_7 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000000000000000000000003398 216.0
TLS2_k127_4067843_0 ABC transporter K06020 - 3.6.3.25 0.0 1019.0
TLS2_k127_4067843_1 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 478.0
TLS2_k127_4067843_2 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 414.0
TLS2_k127_4067843_3 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 359.0
TLS2_k127_4067843_5 Bacterial protein of unknown function (DUF883) - - - 0.00000000000000000000000000001341 122.0
TLS2_k127_4067843_6 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000000000000000009718 91.0
TLS2_k127_4069072_0 Elongator protein 3, MiaB family, Radical SAM - - - 1.94e-206 644.0
TLS2_k127_4069072_1 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 541.0
TLS2_k127_4069072_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005893 256.0
TLS2_k127_4097279_0 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000345 276.0
TLS2_k127_4097279_1 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000033 225.0
TLS2_k127_4097279_2 Protein of unknown function (DUF2726) - - - 0.000000000000000000000000000000000000000000000000000000006096 211.0
TLS2_k127_4097279_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000009897 181.0
TLS2_k127_4097279_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000005663 144.0
TLS2_k127_4098944_0 ABC transporter K06147 - - 1.864e-301 939.0
TLS2_k127_4098944_1 Thioesterase superfamily K10806 - - 0.0000000000000000000000000000000000001496 162.0
TLS2_k127_4102029_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 601.0
TLS2_k127_4102029_1 Carboxyl transferase domain K13778 - 6.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008413 542.0
TLS2_k127_4102029_2 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000000000000301 192.0
TLS2_k127_4102029_3 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000072 171.0
TLS2_k127_4102808_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 3.019e-233 725.0
TLS2_k127_4102808_1 Major Facilitator - - - 1.496e-204 647.0
TLS2_k127_4102808_2 Aminotransferase class I and II K00832 - 2.6.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007904 596.0
TLS2_k127_4102808_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006382 576.0
TLS2_k127_4102808_4 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 389.0
TLS2_k127_4102808_5 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000006691 257.0
TLS2_k127_4102808_6 PFAM Class I peptide chain release factor K15034 - - 0.000000000000000000000000000000000000000000000000003018 186.0
TLS2_k127_4102808_7 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000003494 156.0
TLS2_k127_4119611_0 Tryptophan halogenase K14266 - 1.14.19.9 8.17e-216 696.0
TLS2_k127_4119611_1 MATE efflux family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 529.0
TLS2_k127_4119611_2 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 301.0
TLS2_k127_4119611_3 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000003926 223.0
TLS2_k127_4119611_4 - - - - 0.00007684 52.0
TLS2_k127_4135022_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 7.801e-307 949.0
TLS2_k127_4135022_1 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 312.0
TLS2_k127_4135022_2 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000002441 117.0
TLS2_k127_4135618_0 PFAM sodium hydrogen exchanger K03316 - - 1.099e-207 654.0
TLS2_k127_4135618_1 Domain of unknown function (DUF3391) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 523.0
TLS2_k127_4135618_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 444.0
TLS2_k127_4135618_3 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 344.0
TLS2_k127_4135618_4 Domain of unknown function (DUF1841) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000857 245.0
TLS2_k127_414533_0 Flagellar hook protein FlgE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005876 569.0
TLS2_k127_414533_1 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 493.0
TLS2_k127_414533_2 flagellar basal-body rod protein K02392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 392.0
TLS2_k127_414533_3 Flagellar basal-body rod protein FlgF K02391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 344.0
TLS2_k127_414533_4 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003733 260.0
TLS2_k127_414533_5 TIGRFAM flagellar rod assembly protein muramidase FlgJ K02395 - - 0.00000000000000000000000000000000000002486 156.0
TLS2_k127_415485_0 chemotaxis sensory transducer K03776 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 481.0
TLS2_k127_415485_1 domain, Protein - - - 0.0000000000000004459 80.0
TLS2_k127_415485_2 - - - - 0.00000000000004909 79.0
TLS2_k127_415485_3 Helix-turn-helix domain - - - 0.000000000004048 69.0
TLS2_k127_415485_4 - - - - 0.000000002 63.0
TLS2_k127_4164501_0 CRISPR-associated protein Cse1 (CRISPR_cse1) K19123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 622.0
TLS2_k127_4164501_1 CT1975-like protein K19124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 494.0
TLS2_k127_4164501_2 CRISPR-associated protein (Cas_Cas5) K19125 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 289.0
TLS2_k127_4164501_3 CRISPR_assoc K19126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006704 268.0
TLS2_k127_4164501_4 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette K15342 - - 0.0000000000000000000000000000000000000000001649 163.0
TLS2_k127_4164501_5 CRISPR-associated protein Cse2 (CRISPR_cse2) K19046 - - 0.00000000000000000000000000000000000000001341 166.0
TLS2_k127_4164501_6 Domain of unknown function (DUF3368) - - - 0.00000000000002722 80.0
TLS2_k127_4164501_7 Uncharacterised protein family (UPF0175) - - - 0.00000002616 59.0
TLS2_k127_4167125_0 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 522.0
TLS2_k127_4167125_1 Aminotransferase K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 329.0
TLS2_k127_4167125_2 CheW-like domain K02659 - - 0.000000000000000000000000000000000000000000000000000000000000000000002969 242.0
TLS2_k127_4167125_3 cheY-homologous receiver domain K02657 - - 0.0000000000000000000000000000000000000000000000000000000000000000002775 231.0
TLS2_k127_4167125_4 PFAM response regulator receiver K02658 - - 0.000000000000000000000000000000000000000000000000000000000000000002455 227.0
TLS2_k127_4167125_5 rubredoxin - - - 0.00000000000000000000000000000000472 127.0
TLS2_k127_4168457_0 Amidohydrolase family K01485 - 3.5.4.1 2.312e-227 711.0
TLS2_k127_4168457_1 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 575.0
TLS2_k127_4168457_2 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 376.0
TLS2_k127_4168457_3 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 351.0
TLS2_k127_4168457_4 IIA-like nitrogen-regulatory protein PtsN K02806 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008571 287.0
TLS2_k127_4168457_5 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004804 246.0
TLS2_k127_4168457_6 sigma 54 modulation protein ribosomal protein S30EA K05808 - - 0.0000000000000000000000000000000000000000000000000000000009688 204.0
TLS2_k127_4168457_7 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.000000000000000000000000000000000000000000000000009174 186.0
TLS2_k127_417159_0 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 567.0
TLS2_k127_417159_1 Tripartite tricarboxylate transporter TctA family K07793 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007141 295.0
TLS2_k127_417159_2 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000000000000000000000000000000002818 218.0
TLS2_k127_417159_3 - - - - 0.0000000000000009834 86.0
TLS2_k127_4180651_0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 387.0
TLS2_k127_4180651_1 BON domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001129 229.0
TLS2_k127_4180651_2 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000001108 191.0
TLS2_k127_4180651_3 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000000000000000000000000000009636 169.0
TLS2_k127_4180651_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000004262 125.0
TLS2_k127_4180651_5 Dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000007051 59.0
TLS2_k127_4183853_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 1.524e-260 814.0
TLS2_k127_4183853_1 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000000000000002466 137.0
TLS2_k127_4183853_2 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000000000000000005768 143.0
TLS2_k127_4183853_3 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000000000002917 86.0
TLS2_k127_420533_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 398.0
TLS2_k127_420533_1 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 358.0
TLS2_k127_420533_2 PFAM Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 334.0
TLS2_k127_420533_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000000000000000000000003209 156.0
TLS2_k127_4222302_0 Tfp pilus assembly protein FimV - - - 4.954e-240 755.0
TLS2_k127_4222302_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 3.605e-215 677.0
TLS2_k127_4222302_2 Cobalamin synthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004334 590.0
TLS2_k127_4222302_3 Transporter associated domain K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 435.0
TLS2_k127_4222302_4 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 316.0
TLS2_k127_4222302_5 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003247 287.0
TLS2_k127_4222302_6 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations K01241 - 3.2.2.4 0.000000000000000000000000000000000000000000005261 165.0
TLS2_k127_4222302_7 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000004404 83.0
TLS2_k127_4238828_0 Methyl-accepting chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 492.0
TLS2_k127_4238828_1 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 451.0
TLS2_k127_4238828_2 Translation initiation factor K03113 - - 0.000000000000000000000000000000000000000000005846 165.0
TLS2_k127_4238828_3 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000000003374 168.0
TLS2_k127_4238828_4 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.000000000000000000000000000007314 129.0
TLS2_k127_4251190_0 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 537.0
TLS2_k127_4251190_1 TIGRFAM acetylornithine and succinylornithine K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000001565 232.0
TLS2_k127_4251190_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000003246 205.0
TLS2_k127_4254965_0 Alpha amylase, catalytic domain K01187,K21575 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575 3.2.1.135,3.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 569.0
TLS2_k127_4254965_1 Binding-protein-dependent transport system inner membrane component K10110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 489.0
TLS2_k127_428055_0 OmpA-like transmembrane domain K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001569 284.0
TLS2_k127_428055_1 Beta/Gamma crystallin - - - 0.0000000000000000000000000000000000000000000000000000000004594 210.0
TLS2_k127_4286263_0 AcrB/AcrD/AcrF family K18138,K18303 - - 0.0 1731.0
TLS2_k127_4286263_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 486.0
TLS2_k127_4286263_2 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005685 363.0
TLS2_k127_4292864_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1121.0
TLS2_k127_4292864_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.007e-252 782.0
TLS2_k127_4292864_10 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000000000000000000000000000001033 178.0
TLS2_k127_4292864_11 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000003491 135.0
TLS2_k127_4292864_12 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000000006319 106.0
TLS2_k127_4292864_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 544.0
TLS2_k127_4292864_3 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 466.0
TLS2_k127_4292864_4 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 405.0
TLS2_k127_4292864_5 Forms part of the polypeptide exit tunnel K02926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 379.0
TLS2_k127_4292864_6 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008032 264.0
TLS2_k127_4292864_7 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000001671 198.0
TLS2_k127_4292864_8 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000001692 192.0
TLS2_k127_4292864_9 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000002401 179.0
TLS2_k127_4298832_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1192.0
TLS2_k127_4298832_1 Putative nucleotidyltransferase substrate binding domain K07182 - - 3.527e-225 714.0
TLS2_k127_4298832_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 592.0
TLS2_k127_4298832_3 Alkyl hydroperoxide reductase K03387 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 340.0
TLS2_k127_4298832_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 332.0
TLS2_k127_4298832_5 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000001921 198.0
TLS2_k127_4298832_6 - - - - 0.000000000000000000000000143 110.0
TLS2_k127_4337909_0 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00956 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 597.0
TLS2_k127_4337909_1 Ferredoxin--NADP reductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005987 501.0
TLS2_k127_4337909_2 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 351.0
TLS2_k127_4337909_3 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.00000000000000000000000000000000000000000000000000000000005584 207.0
TLS2_k127_4340407_0 glutamine synthetase K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 1.313e-314 963.0
TLS2_k127_4340407_1 TIGRFAM nitrogen regulation protein NR(I) K07712 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 561.0
TLS2_k127_4340407_2 Histidine kinase K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 561.0
TLS2_k127_4340407_3 - - - - 0.000000000000000000000000000000000000000000000001699 181.0
TLS2_k127_4340407_4 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000007673 128.0
TLS2_k127_4368110_0 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 1.139e-284 881.0
TLS2_k127_4368110_1 AMP-binding enzyme K01897 - 6.2.1.3 5.01e-265 827.0
TLS2_k127_4368110_2 signal transduction protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007802 370.0
TLS2_k127_4368110_3 UPF0056 inner membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 331.0
TLS2_k127_4368110_4 PFAM Ornithine cyclodeaminase mu-crystallin K01750,K19743 - 1.5.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000002242 225.0
TLS2_k127_4368110_5 RNA-binding protein - - - 0.000000000000000000000000000000000000000000000000002647 186.0
TLS2_k127_4368110_6 - - - - 0.000000000000000000000000000000000000000000003943 167.0
TLS2_k127_4376474_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 365.0
TLS2_k127_4376474_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004908 308.0
TLS2_k127_4376474_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001528 287.0
TLS2_k127_4376474_3 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000008775 196.0
TLS2_k127_4376474_4 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000002609 184.0
TLS2_k127_4376474_5 transcriptional regulator K16137 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000008212 160.0
TLS2_k127_4376474_6 LysR substrate binding domain - - - 0.0000000000000000000000000000006124 128.0
TLS2_k127_4376474_7 - - - - 0.000000000000000000001113 100.0
TLS2_k127_439181_0 Peptidoglycan polymerase that is essential for cell division K03588 - - 6.435e-199 628.0
TLS2_k127_439181_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005209 295.0
TLS2_k127_439181_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000008487 116.0
TLS2_k127_4400596_0 TIGRFAM 3-oxoacid CoA-transferase, A subunit K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007526 388.0
TLS2_k127_4400596_1 3-oxoacid CoA-transferase, B subunit K01029 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 391.0
TLS2_k127_4400596_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 286.0
TLS2_k127_4400596_3 Belongs to the UPF0502 family K09915 - - 0.000000000000000000004241 94.0
TLS2_k127_4416774_0 short-chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 434.0
TLS2_k127_4416774_1 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 313.0
TLS2_k127_4416774_2 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003882 266.0
TLS2_k127_4416774_3 Belongs to the UPF0502 family K09915 - - 0.0000000000000000000000000000000000000000000000000000000000008535 213.0
TLS2_k127_4427249_0 PFAM Ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 533.0
TLS2_k127_4427249_1 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000811 247.0
TLS2_k127_4427249_2 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.00000000000000001983 91.0
TLS2_k127_4427453_0 Phage P22-like portal protein - - - 1.277e-203 655.0
TLS2_k127_4427453_1 Protein of unknown function (DUF4043) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 529.0
TLS2_k127_4427453_2 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - 0.000000000000000000000000000000000000000000000000000003091 198.0
TLS2_k127_4427453_3 RyR domain - - - 0.0000000000000000000000000000000000002077 145.0
TLS2_k127_4427453_4 - - - - 0.00000000000000000003256 97.0
TLS2_k127_4427453_6 - - - - 0.000000000004664 72.0
TLS2_k127_4427453_7 - - - - 0.00000000005876 71.0
TLS2_k127_4427453_8 - - - - 0.00000007064 64.0
TLS2_k127_4438200_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1110.0
TLS2_k127_4438200_1 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008253 518.0
TLS2_k127_4438200_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 477.0
TLS2_k127_4438200_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 359.0
TLS2_k127_4438200_4 Domain of unknown function (DUF4845) - - - 0.00000000000000000000000000000000000000000002068 166.0
TLS2_k127_4438200_5 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000176 151.0
TLS2_k127_4477731_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 476.0
TLS2_k127_4477731_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 472.0
TLS2_k127_4504175_0 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007423 269.0
TLS2_k127_4504175_1 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000000000000002119 212.0
TLS2_k127_4506059_0 fad dependent oxidoreductase K07137 - - 1.721e-266 831.0
TLS2_k127_4506059_1 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 503.0
TLS2_k127_4506059_2 - - - - 0.00000000000000000000009719 100.0
TLS2_k127_4506059_3 - - - - 0.0000000000001418 83.0
TLS2_k127_4531670_0 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 545.0
TLS2_k127_4531670_1 FtsZ-dependent cytokinesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 287.0
TLS2_k127_4531670_2 protein import - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001371 281.0
TLS2_k127_4531670_4 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000001105 84.0
TLS2_k127_4545973_0 cytochrome C oxidase - - - 2.892e-232 726.0
TLS2_k127_4545973_1 Belongs to the anaerobic coproporphyrinogen-III oxidase family - GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 1.839e-205 648.0
TLS2_k127_4545973_2 Regulator K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 418.0
TLS2_k127_4545973_3 - - - - 0.000000000000000001135 88.0
TLS2_k127_4545973_4 Protein conserved in bacteria K09926 - - 0.0000000000002277 73.0
TLS2_k127_4555559_0 ABC transporter K06147,K18893 - - 6.66e-278 866.0
TLS2_k127_4555559_1 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 361.0
TLS2_k127_4555559_2 PFAM SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 333.0
TLS2_k127_4555559_3 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000014 261.0
TLS2_k127_4555559_4 peptidase K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000000000000000009196 261.0
TLS2_k127_4555559_5 Bacterial regulatory proteins, tetR family K16137 - - 0.00000000000000000000000000000000000000000000000000002799 194.0
TLS2_k127_4555559_6 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.00000000000000000000000000000000001023 144.0
TLS2_k127_4590060_0 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 529.0
TLS2_k127_4590060_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004623 280.0
TLS2_k127_4590060_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000004803 89.0
TLS2_k127_4620220_0 PFAM FAD dependent oxidoreductase K07137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 393.0
TLS2_k127_4620220_1 17 kDa surface antigen - - - 0.00000000000000000000000000000000000000001046 171.0
TLS2_k127_4651655_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 6.605e-233 727.0
TLS2_k127_4651655_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 3.055e-212 661.0
TLS2_k127_4651655_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006 377.0
TLS2_k127_4656803_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 8.104e-241 749.0
TLS2_k127_4656803_1 cystathionine gamma-synthase activity K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006329 570.0
TLS2_k127_4656803_2 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 328.0
TLS2_k127_4656803_3 Type II secretion system protein B K02451 - - 0.0000000008426 60.0
TLS2_k127_4662456_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 360.0
TLS2_k127_4662456_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 288.0
TLS2_k127_4662456_2 Biotin carboxylase C-terminal domain K01965 - 6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001449 278.0
TLS2_k127_4662456_3 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000001045 179.0
TLS2_k127_4666281_0 GXGXG motif K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1218.0
TLS2_k127_4666281_1 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000001316 144.0
TLS2_k127_4676831_0 OmpA-like transmembrane domain K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008322 376.0
TLS2_k127_4676831_1 Protein of unknown function (DUF3494) - - - 0.000000000000000000000000000000000004651 140.0
TLS2_k127_4694748_0 Yip1 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006618 423.0
TLS2_k127_4694748_1 - - - - 0.0000000000000000000000000000000000000000000000003323 176.0
TLS2_k127_4694748_2 protein kinase activity - - - 0.0000000000000000000000000000007775 127.0
TLS2_k127_469892_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004596 424.0
TLS2_k127_469892_1 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 407.0
TLS2_k127_469892_2 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003838 333.0
TLS2_k127_469892_3 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002578 287.0
TLS2_k127_469892_4 Domain of unknown function (DUF4398) - - - 0.00000000000000000006341 98.0
TLS2_k127_4729976_0 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 497.0
TLS2_k127_4729976_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 338.0
TLS2_k127_4729976_2 Nudix N-terminal K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 306.0
TLS2_k127_4729976_3 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000000000000000001397 130.0
TLS2_k127_4729976_4 - - - - 0.0004827 43.0
TLS2_k127_4741668_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 9.666e-282 872.0
TLS2_k127_4741668_1 Oxidoreductase family, C-terminal alpha/beta domain K13020 - 1.1.1.335 2.089e-204 638.0
TLS2_k127_4741668_2 Belongs to the DegT DnrJ EryC1 family K13017 - 2.6.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004592 585.0
TLS2_k127_4741668_3 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715,K07534 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 417.0
TLS2_k127_4741668_4 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 331.0
TLS2_k127_4741668_5 Hexapeptide repeat of succinyl-transferase K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 325.0
TLS2_k127_4741668_6 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002071 255.0
TLS2_k127_4741668_7 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family - - - 0.000000000000000000000716 96.0
TLS2_k127_4752304_0 Biotin carboxylase K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 350.0
TLS2_k127_4752304_1 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000000000000000000001974 205.0
TLS2_k127_4752304_2 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000663 203.0
TLS2_k127_4752304_3 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000009433 188.0
TLS2_k127_4754788_0 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 4.864e-230 716.0
TLS2_k127_4754788_1 PEP-CTERM exosortase 1-associated glycosyltransferase, Daro_2409 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 305.0
TLS2_k127_4754788_2 PIN domain - - - 0.00000000000000000000000000000000000008971 147.0
TLS2_k127_4764425_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 538.0
TLS2_k127_4764425_1 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 304.0
TLS2_k127_4774411_0 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 458.0
TLS2_k127_4774411_1 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 436.0
TLS2_k127_4774411_2 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 336.0
TLS2_k127_4774411_3 PFAM UspA domain protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001624 287.0
TLS2_k127_4774411_4 DMSO reductase anchor subunit (DmsC) K21309 - - 0.0000000000000000000000000000000000000000000000005978 178.0
TLS2_k127_4774411_5 - - - - 0.000000000000000000000000000000000000000003896 158.0
TLS2_k127_4813629_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 1.013e-196 623.0
TLS2_k127_4813629_1 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 314.0
TLS2_k127_4813629_2 Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000006289 216.0
TLS2_k127_4815519_0 Glycosyl transferase family 41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006443 579.0
TLS2_k127_483032_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 5.696e-254 793.0
TLS2_k127_483032_1 Glutathione S-transferase K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 409.0
TLS2_k127_483032_2 cytochrome c1 K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 397.0
TLS2_k127_483032_3 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009561 336.0
TLS2_k127_483032_4 Starvation protein B K03600 - - 0.00000000000000000000000000000000000000000000000000000000000000001443 228.0
TLS2_k127_483032_5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000000000000000000006774 221.0
TLS2_k127_483032_6 Protein of unknown function (DUF1631) - - - 0.0000000000000000000000000004044 115.0
TLS2_k127_483722_0 Sigma-54 interaction domain - - - 8.754e-212 670.0
TLS2_k127_483722_1 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 321.0
TLS2_k127_483722_2 Nitrate reductase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000007238 230.0
TLS2_k127_4886129_0 NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 467.0
TLS2_k127_4886129_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000677 248.0
TLS2_k127_4886129_2 Cytochrome c K08738 - - 0.000001025 56.0
TLS2_k127_4886129_3 Pfam cytochrome c K08738 - - 0.0001707 49.0
TLS2_k127_4913788_0 Zn_pept - - - 0.0 1010.0
TLS2_k127_4913788_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 326.0
TLS2_k127_4913788_2 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000006176 205.0
TLS2_k127_4913788_3 Transcriptional regulator - - - 0.0000000000000000000000000000005625 126.0
TLS2_k127_4913913_0 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005081 568.0
TLS2_k127_4913913_1 PFAM binding-protein-dependent transport systems inner membrane component K02034,K12370 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 489.0
TLS2_k127_4913913_2 Belongs to the ABC transporter superfamily K02031,K12371 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 486.0
TLS2_k127_4913913_3 Oligopeptide/dipeptide transporter, C-terminal region K12372 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 417.0
TLS2_k127_4917067_0 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 518.0
TLS2_k127_4917067_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 445.0
TLS2_k127_4921813_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.0 1077.0
TLS2_k127_4921813_1 NADPH-dependent glutamate synthase beta - - - 6.142e-206 645.0
TLS2_k127_4921813_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 346.0
TLS2_k127_4925658_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 2.214e-217 681.0
TLS2_k127_4925658_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 533.0
TLS2_k127_4925658_2 - - - - 0.000000000000543 70.0
TLS2_k127_4925810_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 610.0
TLS2_k127_4925810_1 PFAM Glycosyl transferases group 1 K12995 - 2.4.1.348 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 357.0
TLS2_k127_4925810_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000001127 166.0
TLS2_k127_4925810_3 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000009237 124.0
TLS2_k127_4994946_0 ABC transporter K06158 - - 1.284e-284 884.0
TLS2_k127_4994946_1 Belongs to the protein N5-glutamine methyltransferase family K07320 - 2.1.1.298 0.000000000000000001644 86.0
TLS2_k127_4998954_0 PrkA AAA domain K07180 - - 0.0 1224.0
TLS2_k127_4998954_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009928 473.0
TLS2_k127_4998954_2 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 467.0
TLS2_k127_4998954_3 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 412.0
TLS2_k127_4998954_4 Alpha beta hydrolase K07002 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007417 253.0
TLS2_k127_5015144_0 Transcriptional regulator K13634,K13635 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 483.0
TLS2_k127_5015144_1 Domain of unknown function (DUF4143) K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005963 408.0
TLS2_k127_5015144_2 TonB dependent receptor - - - 0.00000000000000000002448 96.0
TLS2_k127_5015144_3 Metal-dependent hydrolase - - - 0.0000002499 53.0
TLS2_k127_5024213_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 304.0
TLS2_k127_5024213_1 - - - - 0.00000000000000000000000000000000002355 137.0
TLS2_k127_5024213_2 Killing trait - - - 0.000000000000000000000000000234 121.0
TLS2_k127_5024213_3 - - - - 0.0000000000000000000000005382 111.0
TLS2_k127_5040800_0 Alcohol dehydrogenase GroES-like domain K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 531.0
TLS2_k127_5040800_1 Protein of unknown function (DUF3297) - - - 0.000000000000000000000000000000000001255 139.0
TLS2_k127_5040800_3 uroporphyrinogen-III synthase activity K01719,K01749,K02496,K13542,K13543 GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.0000005834 52.0
TLS2_k127_504455_0 Diguanylate cyclase - - - 3.132e-220 703.0
TLS2_k127_504455_1 peptidase dimerisation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 612.0
TLS2_k127_504455_2 Domain of unknown function (DUF3391) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 467.0
TLS2_k127_504455_3 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000000000000000000000003606 181.0
TLS2_k127_504455_4 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000001062 152.0
TLS2_k127_504499_0 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006557 486.0
TLS2_k127_504499_1 Belongs to the ParA family K04562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 370.0
TLS2_k127_504499_2 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 343.0
TLS2_k127_504499_3 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 321.0
TLS2_k127_504499_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000003886 242.0
TLS2_k127_504499_5 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000000000000006521 179.0
TLS2_k127_5051585_0 aminotransferase class I and II - - - 2.091e-196 618.0
TLS2_k127_5051585_1 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000000000000000000000000003638 234.0
TLS2_k127_5051585_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000002411 207.0
TLS2_k127_5053326_0 Protein of unknown function (DUF3683) - - - 3.944e-263 821.0
TLS2_k127_5056364_0 Membrane transport protein K07088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 406.0
TLS2_k127_5056364_1 Riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000001535 220.0
TLS2_k127_5056364_2 Outer membrane efflux protein K12543 - - 0.000000000000000000000000000000000000000000358 171.0
TLS2_k127_5063950_0 CBS domain containing protein K03699 - - 4.497e-199 629.0
TLS2_k127_5063950_1 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009746 473.0
TLS2_k127_5063950_2 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 411.0
TLS2_k127_5063950_3 SapC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000797 278.0
TLS2_k127_5063950_4 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs K05541 - - 0.0000000000000000000000000000000000009703 145.0
TLS2_k127_5066591_0 Major facilitator Superfamily K08162,K08226,K16211 - - 8.611e-250 782.0
TLS2_k127_5066591_1 L-asparaginase II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 477.0
TLS2_k127_5066591_2 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000006195 213.0
TLS2_k127_5066591_3 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000000000000000000000000000009081 206.0
TLS2_k127_5066591_4 PFAM DNA polymerase, beta domain protein region K07075 - - 0.00000000000000000000000000000000000000000000006491 170.0
TLS2_k127_5066591_5 Isochorismate synthase K01851,K02361,K02552 - 5.4.4.2 0.000000000000001011 79.0
TLS2_k127_5066591_6 DEAD-like helicases superfamily K07012 - - 0.00009551 44.0
TLS2_k127_5080738_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1558.0
TLS2_k127_5080738_1 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002323 268.0
TLS2_k127_5080738_2 CRS1_YhbY K07574 - - 0.00000000000000000000000000000000000000000000000000005455 189.0
TLS2_k127_5080738_3 Domain of unknown function (DUF4149) - - - 0.00000000000000000000000000000000000000000000000003444 183.0
TLS2_k127_5101209_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 431.0
TLS2_k127_5101209_1 Molybdopterin biosynthesis MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000002547 246.0
TLS2_k127_5101209_2 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000224 183.0
TLS2_k127_5101209_3 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000000000000000000000002906 106.0
TLS2_k127_510234_0 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 586.0
TLS2_k127_510234_1 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 372.0
TLS2_k127_510234_2 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 345.0
TLS2_k127_510234_3 SMART Extracellular solute-binding protein, family 3 K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 297.0
TLS2_k127_510234_4 Outer membrane protein beta-barrel family K02014 - - 0.000000000000000000000000000000000000005524 149.0
TLS2_k127_510234_5 May be involved in recombination K03554 - - 0.0000000000000000000000000000000001255 136.0
TLS2_k127_5146381_0 cytochrome C K02198 - - 0.0 1012.0
TLS2_k127_5146381_1 NADPH-dependent glutamate synthase beta - - - 0.0 1002.0
TLS2_k127_5146381_10 PFAM Plasmid maintenance system killer K07334 - - 0.00000000000000000000000000000000000672 138.0
TLS2_k127_5146381_11 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000009793 48.0
TLS2_k127_5146381_2 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 4.786e-237 738.0
TLS2_k127_5146381_3 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K18356 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006315 601.0
TLS2_k127_5146381_4 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 336.0
TLS2_k127_5146381_5 Cytochrome c-type biogenesis protein K02200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 322.0
TLS2_k127_5146381_6 Periplasmic protein thiol K02199 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001251 274.0
TLS2_k127_5146381_7 Pyruvate ferredoxin/flavodoxin oxidoreductase K18357 - 1.2.1.58 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009411 269.0
TLS2_k127_5146381_8 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000008639 158.0
TLS2_k127_5146381_9 TIGRFAM Addiction module antidote protein, HigA K21498 - - 0.000000000000000000000000000000000001404 140.0
TLS2_k127_5174517_0 - K07484 - - 0.0000000000000000000000000000000000000000000000000000977 195.0
TLS2_k127_5174517_1 Transposase IS66 family K07484 - - 0.00000000002676 74.0
TLS2_k127_5174517_2 - - - - 0.000001373 57.0
TLS2_k127_5174517_3 rRNA (guanine-N2-)-methyltransferase activity - - - 0.0001326 51.0
TLS2_k127_5188355_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 6.386e-262 825.0
TLS2_k127_5188355_1 Tetratricopeptide repeat - - - 2.609e-250 803.0
TLS2_k127_5188355_10 TIGRFAM polysaccharide chain length determinant protein, PEP-CTERM locus subfamily - - - 0.000000000000000000000000001968 113.0
TLS2_k127_5188355_12 Ferredoxin - - - 0.0000000001291 75.0
TLS2_k127_5188355_2 Sigma-54 interaction domain K02481,K10126,K10941 - - 7.347e-231 722.0
TLS2_k127_5188355_3 TIGRFAM sugar transferase, PEP-CTERM system associated K21303 - 2.7.8.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 612.0
TLS2_k127_5188355_4 MMPL family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 571.0
TLS2_k127_5188355_5 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 446.0
TLS2_k127_5188355_6 polysaccharide export K01991 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 316.0
TLS2_k127_5188355_7 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005267 270.0
TLS2_k127_5188355_8 PEP-CTERM motif - - - 0.0000000000000000000000000000000000000000000000002252 185.0
TLS2_k127_5188355_9 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000001082 129.0
TLS2_k127_5197249_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1650.0
TLS2_k127_5197249_1 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 4e-323 999.0
TLS2_k127_5197249_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000002258 228.0
TLS2_k127_5197249_3 SWI complex, BAF60b domains - - - 0.000000000000000000000000000000000000000000000001277 176.0
TLS2_k127_5203318_0 ABC transporter K10111 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 497.0
TLS2_k127_5203318_1 Glycosyl hydrolase family 1 K01223,K05350 - 3.2.1.21,3.2.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 477.0
TLS2_k127_5203318_2 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000008413 175.0
TLS2_k127_5238842_0 Glycosyltransferase family 92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 343.0
TLS2_k127_5238842_1 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001086 286.0
TLS2_k127_5238842_2 ORF6N domain - - - 0.0000000000000000000000000000000000000000000001326 175.0
TLS2_k127_5238842_3 Outer membrane efflux protein K12543 - - 0.000000000000000000000000000000009726 131.0
TLS2_k127_5253275_0 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000762 476.0
TLS2_k127_5253275_1 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 437.0
TLS2_k127_5253275_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 362.0
TLS2_k127_5253275_3 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007282 347.0
TLS2_k127_5253275_4 Bacterial transcriptional repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000001421 254.0
TLS2_k127_5253275_5 Belongs to the BolA IbaG family - - - 0.0000000000000000000000000000000000002872 146.0
TLS2_k127_5256207_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 6e-323 993.0
TLS2_k127_5256207_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 569.0
TLS2_k127_5256207_2 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 486.0
TLS2_k127_5265254_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 3.365e-321 990.0
TLS2_k127_5265254_1 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 431.0
TLS2_k127_5265254_2 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003092 282.0
TLS2_k127_5265254_3 Lysine exporter protein (Lyse ygga) K11250 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001895 280.0
TLS2_k127_5265254_4 FR47-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000004357 226.0
TLS2_k127_5288389_0 Histidine Phosphotransfer domain - - - 2.072e-247 786.0
TLS2_k127_5288389_1 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 606.0
TLS2_k127_5288389_2 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000000002182 233.0
TLS2_k127_5288389_3 gag-polyprotein putative aspartyl protease K06985 - - 0.000000000000000000000000000000000000000000000000000304 197.0
TLS2_k127_533156_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 2.513e-222 703.0
TLS2_k127_533156_1 Luciferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 524.0
TLS2_k127_533156_2 Transcriptional regulator K18900 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 488.0
TLS2_k127_533156_3 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000000000009303 216.0
TLS2_k127_533156_4 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 4.3.99.3 0.00000000000000000000000000000000000000000000005034 195.0
TLS2_k127_533156_5 PFAM thioesterase superfamily K02614 - - 0.0000000000000003735 81.0
TLS2_k127_5353476_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 4.203e-261 811.0
TLS2_k127_5353476_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 488.0
TLS2_k127_5353476_2 - - - - 0.000000000000000000000000003279 112.0
TLS2_k127_5369739_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 462.0
TLS2_k127_5369739_1 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 409.0
TLS2_k127_5369739_2 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000000000000001707 236.0
TLS2_k127_538353_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 6.377e-301 932.0
TLS2_k127_538353_1 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000000000001799 197.0
TLS2_k127_5409237_0 PFAM extracellular solute-binding protein family 1 K05813 - - 4.094e-218 685.0
TLS2_k127_5409237_1 PFAM binding-protein-dependent transport systems inner membrane component K05814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 492.0
TLS2_k127_5409237_2 probably responsible for the translocation of the substrate across the membrane K02026,K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006422 469.0
TLS2_k127_5409237_3 Belongs to the ABC transporter superfamily K05816,K10111,K10112 - 3.6.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 289.0
TLS2_k127_5409831_0 PFAM Orn DAP Arg decarboxylase 2 K01586 - 4.1.1.20 6.859e-203 637.0
TLS2_k127_5409831_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000568 150.0
TLS2_k127_5409831_2 PIN domain - - - 0.0000000000000000000000000000000000000873 145.0
TLS2_k127_5409831_3 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000000005969 91.0
TLS2_k127_5412180_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 7.764e-236 734.0
TLS2_k127_5412180_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 595.0
TLS2_k127_5412180_2 Type IV pilus biogenesis stability protein PilW K02656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002421 279.0
TLS2_k127_5412180_3 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000684 243.0
TLS2_k127_5412180_4 Domain of unknown function (DUF4115) K15539 - - 0.0000000000000000000000000000000000000000000000000000000000006884 222.0
TLS2_k127_5413614_0 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 525.0
TLS2_k127_5413614_1 Phospholipase/Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 327.0
TLS2_k127_5413614_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000034 228.0
TLS2_k127_5413614_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000008408 157.0
TLS2_k127_5418492_0 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 0.0 1342.0
TLS2_k127_5418492_1 acyl-CoA dehydrogenase - - - 0.0 1039.0
TLS2_k127_5418492_10 Tellurite resistance protein TehB - - - 0.000006434 55.0
TLS2_k127_5418492_2 Belongs to the thiolase family K00632 - 2.3.1.16 4.913e-221 692.0
TLS2_k127_5418492_3 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 546.0
TLS2_k127_5418492_4 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 412.0
TLS2_k127_5418492_5 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 354.0
TLS2_k127_5418492_6 regulatory - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 329.0
TLS2_k127_5418492_7 outer membrane lipoprotein K06077 - - 0.0000000000000000000000000000000000000000000000000002532 189.0
TLS2_k127_5418492_8 GDSL-like Lipase/Acylhydrolase family - - - 0.00000004449 59.0
TLS2_k127_5418492_9 Protein of unknown function (DUF2934) - - - 0.000003484 53.0
TLS2_k127_5434850_0 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 0.0 1046.0
TLS2_k127_5434850_1 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 382.0
TLS2_k127_5434850_10 - - - - 0.0000000000000000000000000000004436 131.0
TLS2_k127_5434850_11 Addiction module antidote - - - 0.00000000000000000000000000007321 117.0
TLS2_k127_5434850_2 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009904 372.0
TLS2_k127_5434850_3 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006061 274.0
TLS2_k127_5434850_4 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001007 273.0
TLS2_k127_5434850_5 Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000002198 244.0
TLS2_k127_5434850_6 TIGRFAM death-on-curing family protein K07341 - - 0.000000000000000000000000000000000000000000000000000009984 192.0
TLS2_k127_5434850_7 Belongs to the urease gamma subunit family K01430 - 3.5.1.5 0.00000000000000000000000000000000000000000000001072 172.0
TLS2_k127_5434850_8 Belongs to the urease beta subunit family K01429 - 3.5.1.5 0.0000000000000000000000000000000000000000001649 163.0
TLS2_k127_5434850_9 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000009578 162.0
TLS2_k127_5454456_0 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 581.0
TLS2_k127_5454456_1 Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008422 444.0
TLS2_k127_5454456_2 Nudix hydrolase K08310 - 3.6.1.67 0.000000000000000000000000000000000000000000000000000000000000001305 222.0
TLS2_k127_5460155_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1193.0
TLS2_k127_5460155_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000003737 94.0
TLS2_k127_549330_0 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 526.0
TLS2_k127_549330_1 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 401.0
TLS2_k127_549330_2 helix_turn_helix ASNC type - - - 0.0000000000000000000000000000000000000000000000000000000002084 205.0
TLS2_k127_549330_3 - - - - 0.0000000000000000000000000000000000000000000000000000000805 201.0
TLS2_k127_5498809_0 Predicted membrane protein (DUF2339) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006436 396.0
TLS2_k127_5498809_1 Protein of unknown function (DUF3999) - - - 0.00000000000000000000000003568 123.0
TLS2_k127_5500432_0 Pfam:Methyltransf_26 - - - 0.0 1065.0
TLS2_k127_5527090_0 Belongs to the ABC transporter superfamily K02031,K02032,K10823,K13896,K15583 - - 5.497e-223 698.0
TLS2_k127_5527090_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 522.0
TLS2_k127_5527090_2 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000956 539.0
TLS2_k127_5527090_3 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000000001592 100.0
TLS2_k127_5529946_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007575 535.0
TLS2_k127_5529946_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009548 487.0
TLS2_k127_5529946_2 malonyl CoA-acyl carrier protein transacylase K00645,K15355 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 451.0
TLS2_k127_5550038_0 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 556.0
TLS2_k127_5550038_1 Binding-protein-dependent transport system inner membrane component K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 430.0
TLS2_k127_5550038_2 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.000000000000000002092 98.0
TLS2_k127_5550038_3 Serine threonine protein kinase K12132 - 2.7.11.1 0.0003759 52.0
TLS2_k127_5555575_0 carbohydrate binding K13688 - - 1.273e-249 785.0
TLS2_k127_5566939_0 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 1.865e-251 801.0
TLS2_k127_5566939_1 Aldose 1-epimerase K01785 - 5.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 424.0
TLS2_k127_5566939_2 SMP-30 Gluconolaconase K13874,K14274 - 3.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 423.0
TLS2_k127_5566939_3 Cytochrome C biogenesis protein transmembrane region K04084,K08344 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 380.0
TLS2_k127_5566939_4 FR47-like protein - - - 0.00000000000000000000000000000000008487 134.0
TLS2_k127_5574979_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0 1047.0
TLS2_k127_5574979_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 1.022e-253 792.0
TLS2_k127_5574979_2 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.0000000000000000000000000000000000000000000000002117 179.0
TLS2_k127_5574979_3 Pfam:DUF1049 K08992 - - 0.00000000000000000000000000000000223 131.0
TLS2_k127_5595755_0 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 5.255e-275 853.0
TLS2_k127_5595755_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 593.0
TLS2_k127_5595755_2 NADH-quinone oxidoreductase K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 347.0
TLS2_k127_5595755_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 320.0
TLS2_k127_5595755_4 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000411 272.0
TLS2_k127_5595755_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000000000000000005189 173.0
TLS2_k127_56030_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000334 254.0
TLS2_k127_56030_1 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000002059 141.0
TLS2_k127_56030_2 carboxylic acid catabolic process K01776,K02549,K19802 GO:0008150,GO:0040007 4.2.1.113,5.1.1.20,5.1.1.3 0.00000007278 55.0
TLS2_k127_560639_0 Exostosin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 486.0
TLS2_k127_560639_1 Protein of unknown function (DUF563) - - - 0.00000000001224 76.0
TLS2_k127_5611726_0 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 506.0
TLS2_k127_5611726_1 LysR substrate binding domain K21703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 391.0
TLS2_k127_5611726_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000008928 218.0
TLS2_k127_5611726_3 PFAM Tannase and feruloyl esterase K21105 - 3.1.1.102 0.00000002067 60.0
TLS2_k127_5717086_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 0.0 1059.0
TLS2_k127_5717086_1 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004436 372.0
TLS2_k127_5717086_2 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000000005291 195.0
TLS2_k127_5717495_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0 1159.0
TLS2_k127_5717495_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.944e-307 944.0
TLS2_k127_5717495_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 7.882e-194 609.0
TLS2_k127_5717495_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 331.0
TLS2_k127_5717495_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000000000000000226 212.0
TLS2_k127_5717495_5 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000000000000000000138 205.0
TLS2_k127_5717495_6 regulatory protein, MerR - - - 0.00000000000000000000000000000000000000000000000000007582 189.0
TLS2_k127_5717495_7 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000000000000000008318 126.0
TLS2_k127_5717495_8 - - - - 0.000000000006262 66.0
TLS2_k127_5733118_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 7.442e-276 863.0
TLS2_k127_5733118_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 499.0
TLS2_k127_5733118_2 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 418.0
TLS2_k127_5733118_3 Doxx family K15977 - - 0.00000000000000000000000000000000000000000000000000000000000000000513 234.0
TLS2_k127_5733118_4 Cupin - - - 0.000000000000000000000000000000000000000000000000000000004735 210.0
TLS2_k127_5733118_5 monooxygenase activity - - - 0.00000000000000000000000000000000002149 138.0
TLS2_k127_573915_0 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 458.0
TLS2_k127_573915_1 Alpha beta hydrolase K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001468 276.0
TLS2_k127_573915_2 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000015 160.0
TLS2_k127_5741893_0 Peptidase family M1 domain - - - 1.892e-309 960.0
TLS2_k127_5741893_1 - - - - 0.0000000000000000000000000000000000000004171 160.0
TLS2_k127_5741893_2 - - - - 0.00000886 48.0
TLS2_k127_5750409_0 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 509.0
TLS2_k127_5750409_1 Protein of unknown function (DUF429) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 398.0
TLS2_k127_5750409_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 327.0
TLS2_k127_5750409_3 Staphylococcal nuclease homologue - - - 0.000000000008049 69.0
TLS2_k127_5782124_0 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009471 323.0
TLS2_k127_5782124_1 Outer membrane protein beta-barrel family K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000005162 233.0
TLS2_k127_5782124_2 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000001346 253.0
TLS2_k127_5786778_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 5.084e-249 779.0
TLS2_k127_5786778_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 531.0
TLS2_k127_5786778_2 binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000000000000000000000002941 231.0
TLS2_k127_5786778_3 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000000000000000000000000000002919 179.0
TLS2_k127_5786778_4 Binds single-stranded DNA at the primosome assembly site (PAS) K02686 - - 0.000000000000000000000000000006098 122.0
TLS2_k127_5810498_0 Eukaryotic-type carbonic anhydrase K01674 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 350.0
TLS2_k127_5810498_1 Cache domain - - - 0.000000000000000000000000000000000000002816 157.0
TLS2_k127_5813035_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 606.0
TLS2_k127_5813035_1 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006341 599.0
TLS2_k127_5813035_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 443.0
TLS2_k127_5813035_3 - - - - 0.00000000000000000000000000000000000007302 145.0
TLS2_k127_5813035_4 PFAM thiamineS protein - - - 0.0000000000000000000000000000000000008712 140.0
TLS2_k127_5813035_5 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000007607 135.0
TLS2_k127_5832878_0 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 441.0
TLS2_k127_5832878_1 PFAM Ornithine cyclodeaminase mu-crystallin K01750,K19743 - 1.5.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 376.0
TLS2_k127_5832878_2 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000008266 207.0
TLS2_k127_5832878_3 PFAM regulatory protein, MarR - - - 0.00000000000000000000000000000000000001161 164.0
TLS2_k127_5832878_4 Belongs to the UPF0311 family - - - 0.0000000000002127 70.0
TLS2_k127_5837962_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1304.0
TLS2_k127_5837962_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) K11711 - 2.7.13.3 3.142e-252 797.0
TLS2_k127_5837962_2 helix_turn_helix, Lux Regulon K11712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 314.0
TLS2_k127_5837962_3 Barstar (barnase inhibitor) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002322 242.0
TLS2_k127_5837962_4 guanine-specific ribonuclease N1 and T1 K01167 - 3.1.27.3 0.00000000000000000000000000000000000000004755 156.0
TLS2_k127_5847892_0 Transposase zinc-ribbon domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 536.0
TLS2_k127_5847892_1 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 449.0
TLS2_k127_5847892_2 PFAM Transposase, IS801 IS1294 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002847 272.0
TLS2_k127_5915241_0 Mitochondrial degradasome RNA helicase subunit C terminal K17675 - 3.6.4.13 6.075e-308 951.0
TLS2_k127_5915241_1 PFAM Activator of Hsp90 ATPase 1 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001256 275.0
TLS2_k127_5915241_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000795 233.0
TLS2_k127_5915241_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000004028 151.0
TLS2_k127_5915241_4 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.00001749 48.0
TLS2_k127_592767_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 7.553e-234 736.0
TLS2_k127_592767_1 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 1.329e-223 702.0
TLS2_k127_592767_2 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 345.0
TLS2_k127_592767_3 HAD-superfamily hydrolase, subfamily IB (PSPase-like) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 335.0
TLS2_k127_592767_4 Belongs to the DnaA family K10763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 302.0
TLS2_k127_592767_5 Protein of unknown function (DUF3579) - - - 0.00000000000000000000000000000000000000002797 156.0
TLS2_k127_592767_6 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000000000000000000003326 156.0
TLS2_k127_5934258_0 Peptidase M48 K06013 - 3.4.24.84 6.472e-200 631.0
TLS2_k127_5934258_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 580.0
TLS2_k127_5934258_2 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 332.0
TLS2_k127_5934258_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000001183 230.0
TLS2_k127_5934258_4 PFAM Transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000001629 154.0
TLS2_k127_5963045_0 Domain of unknown function (DUF4178) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 561.0
TLS2_k127_5963045_1 SPFH domain-Band 7 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000744 572.0
TLS2_k127_5963045_2 UbiH UbiF VisC COQ6 family K03185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 481.0
TLS2_k127_5972122_0 ABC transporter transmembrane region K06147,K18893 - - 1.503e-300 937.0
TLS2_k127_5972122_1 Belongs to the UbiD family K03182 - 4.1.1.98 9.745e-288 892.0
TLS2_k127_5972122_2 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 2.328e-225 709.0
TLS2_k127_5972122_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006859 427.0
TLS2_k127_5972122_4 lytic transglycosylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 360.0
TLS2_k127_5985784_0 Belongs to the thiolase family K00626 - 2.3.1.9 3.734e-211 660.0
TLS2_k127_5985784_1 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005854 467.0
TLS2_k127_5985784_2 PFAM acyl-CoA dehydrogenase domain protein K09456 - - 0.000000000000000000000000000000000000000000000000000000000000000000001506 249.0
TLS2_k127_5985784_3 Acetyltransferase (GNAT) domain K02348 - - 0.0000000000000000000000000000000000000000000000000000000000000000487 226.0
TLS2_k127_5985784_5 - - - - 0.0007322 46.0
TLS2_k127_6037576_0 Tryptophan halogenase - - - 2.229e-223 702.0
TLS2_k127_6037576_1 SapC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 306.0
TLS2_k127_6037576_2 Cupin-like domain - - - 0.00000157 56.0
TLS2_k127_6061997_0 Dehydrogenase K00382 - 1.8.1.4 1.138e-285 886.0
TLS2_k127_6061997_1 Sigma-70, region 4 K02405 - - 0.00000000000000000000000000000000000000001184 158.0
TLS2_k127_6078441_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.111e-318 983.0
TLS2_k127_6078441_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 567.0
TLS2_k127_6086153_0 acyl-CoA dehydrogenase K00252 - 1.3.8.6 1.168e-226 707.0
TLS2_k127_6086153_1 Penicillin amidase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 345.0
TLS2_k127_6086153_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000002103 263.0
TLS2_k127_6086153_3 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001219 261.0
TLS2_k127_6086153_4 import inner membrane translocase subunit Tim44 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003146 245.0
TLS2_k127_6086153_5 - - - - 0.00000000000000000000000009464 112.0
TLS2_k127_6086153_6 - - - - 0.00000000000006507 81.0
TLS2_k127_6093274_0 PFAM acyl-CoA dehydrogenase domain protein K00249,K11731 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000003849 230.0
TLS2_k127_6093274_1 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000007278 165.0
TLS2_k127_6093274_2 Psort location Cytoplasmic, score K00059 - 1.1.1.100 0.00000000000000000000000000000000000001195 157.0
TLS2_k127_609700_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 566.0
TLS2_k127_609700_1 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 483.0
TLS2_k127_609700_2 FAD dependent oxidoreductase K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 470.0
TLS2_k127_609700_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006181 454.0
TLS2_k127_609700_4 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 453.0
TLS2_k127_609700_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 435.0
TLS2_k127_609700_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 411.0
TLS2_k127_609700_7 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 304.0
TLS2_k127_6097506_0 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 9.291e-209 669.0
TLS2_k127_6097506_1 Zinc transporter K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004819 387.0
TLS2_k127_6097506_2 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002492 240.0
TLS2_k127_6097506_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000009645 203.0
TLS2_k127_6097791_0 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 558.0
TLS2_k127_6097791_1 Belongs to the peptidase S8 family K20276 - - 0.0000000000000000000000000000000000000000000000000000006534 209.0
TLS2_k127_6107296_0 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 2.801e-257 797.0
TLS2_k127_6107296_1 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000000000000000000002902 164.0
TLS2_k127_6107296_2 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000002514 158.0
TLS2_k127_6107296_3 Histone family protein nucleoid-structuring protein H-NS K03746 - - 0.00000000006138 68.0
TLS2_k127_6124873_0 Glucose / Sorbosone dehydrogenase - - - 8.247e-244 754.0
TLS2_k127_6124873_1 TonB dependent receptor K02014 - - 7.778e-212 678.0
TLS2_k127_6124873_2 PFAM Cytochrome C - - - 0.000000000000000000000000000001501 123.0
TLS2_k127_6129727_0 5'-nucleotidase, C-terminal domain K01119 - 3.1.3.6,3.1.4.16 5.244e-253 796.0
TLS2_k127_6129727_1 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007059 479.0
TLS2_k127_6129727_2 Exonuclease C-terminal K01141 - 3.1.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 403.0
TLS2_k127_6129727_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000001557 225.0
TLS2_k127_6132068_0 type II secretion system protein E K02454,K02652 - - 4.106e-311 967.0
TLS2_k127_6132068_1 Transmembrane secretion effector - - - 3.432e-215 686.0
TLS2_k127_6132068_2 Spermidine synthase K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 346.0
TLS2_k127_6142487_0 ThiF family K22132 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 351.0
TLS2_k127_6142487_1 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003205 279.0
TLS2_k127_6142487_2 YHS domain protein - - - 0.0000000000000000000000000000000000000000000000000000000009362 206.0
TLS2_k127_6146020_0 PFAM aldo keto reductase K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008326 448.0
TLS2_k127_6146020_1 AraC family transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 335.0
TLS2_k127_6146020_2 Riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000001201 217.0
TLS2_k127_6146020_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000002013 165.0
TLS2_k127_615226_0 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 442.0
TLS2_k127_615226_1 Histidine kinase K07645 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 291.0
TLS2_k127_615226_2 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000001055 140.0
TLS2_k127_6167743_0 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 294.0
TLS2_k127_6167743_1 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000006001 203.0
TLS2_k127_6167743_2 structural constituent of ribosome - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 0.00000000007846 64.0
TLS2_k127_6183824_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 419.0
TLS2_k127_6183824_1 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 351.0
TLS2_k127_6183824_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 331.0
TLS2_k127_6195853_0 NAD(P)H-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008892 418.0
TLS2_k127_6195853_1 Belongs to the ClpA ClpB family K03694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 351.0
TLS2_k127_6195853_2 chorismate binding enzyme K01665,K13950 - 2.6.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001052 296.0
TLS2_k127_6195853_3 chorismate lyase activity - - - 0.000000000000000000000000000000000005787 144.0
TLS2_k127_6195853_4 'Cold-shock' DNA-binding domain K03704 - - 0.0000000000000000000000000000000009015 131.0
TLS2_k127_6195853_5 AMP binding - - - 0.0000000000000000000000000000269 126.0
TLS2_k127_6203541_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.945e-242 754.0
TLS2_k127_6203541_1 HDOD domain K08282 - 2.7.11.1 2.202e-208 664.0
TLS2_k127_6203541_2 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008997 230.0
TLS2_k127_6203541_3 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000000000000000004349 209.0
TLS2_k127_6221380_0 peptidylprolyl isomerase K03770 - 5.2.1.8 1.373e-219 701.0
TLS2_k127_6221380_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000008993 180.0
TLS2_k127_6221380_2 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000001799 138.0
TLS2_k127_6243081_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD K03581 - 3.1.11.5 1.915e-201 646.0
TLS2_k127_6243081_1 AsmA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 618.0
TLS2_k127_6243081_2 PFAM plasmid K06218 - - 0.000000000000000000000000001307 114.0
TLS2_k127_6243081_3 - - - - 0.0000000000001028 74.0
TLS2_k127_6250734_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 602.0
TLS2_k127_6250734_1 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007015 540.0
TLS2_k127_6250734_2 Domain of unknown function (DUF3394) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 537.0
TLS2_k127_6250734_3 Protein of unknown function (DUF2905) - - - 0.0000000000000000001202 97.0
TLS2_k127_6250734_4 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.000176 44.0
TLS2_k127_6260954_0 Belongs to the GPI family K01810 - 5.3.1.9 7.772e-265 828.0
TLS2_k127_6260954_1 addiction module toxin RelE StbE family - - - 0.00000000000000000005347 96.0
TLS2_k127_6274268_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 1.216e-235 736.0
TLS2_k127_6274268_1 FAD dependent oxidoreductase K09471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 447.0
TLS2_k127_6274268_2 helix_turn_helix ASNC type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001789 253.0
TLS2_k127_6274268_3 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000006764 201.0
TLS2_k127_6279897_0 histidine kinase A domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 409.0
TLS2_k127_6279897_1 Histidine kinase A domain protein K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 343.0
TLS2_k127_6279897_2 luxR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 301.0
TLS2_k127_6279897_3 PFAM EAL domain - - - 0.00000000000000000000000000000000000104 161.0
TLS2_k127_6299823_0 TIGRFAM phosphate regulon sensor kinase PhoR K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 557.0
TLS2_k127_6299823_1 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 401.0
TLS2_k127_6299823_2 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 381.0
TLS2_k127_6299823_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000004897 201.0
TLS2_k127_6326764_0 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004591 374.0
TLS2_k127_6326764_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000004414 86.0
TLS2_k127_6327533_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 1103.0
TLS2_k127_6327533_1 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004901 271.0
TLS2_k127_6327533_2 CcdB-like toxin protein K19163 - - 0.000000000000006968 78.0
TLS2_k127_6327533_3 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000695 52.0
TLS2_k127_6330367_0 Aminotransferase K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007632 610.0
TLS2_k127_6330367_1 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000001827 272.0
TLS2_k127_6330367_2 chemotaxis K03406,K03776,K05875 - - 0.0000000000000000000000000000000000000000000000000000000000001027 217.0
TLS2_k127_6341734_0 TonB-dependent receptor K02014 - - 1.498e-290 915.0
TLS2_k127_6341734_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000001252 131.0
TLS2_k127_6341734_2 CHRD domain - - - 0.0000000000000000000000143 104.0
TLS2_k127_6341734_3 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000003698 91.0
TLS2_k127_6341734_4 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000004649 75.0
TLS2_k127_6341734_5 Protein of unknown function (DUF2946) - - - 0.00000000008083 67.0
TLS2_k127_6347177_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 7.614e-295 913.0
TLS2_k127_6347177_1 ABC-type dipeptide transport system, periplasmic component - - - 3.69e-205 649.0
TLS2_k127_6347384_0 Tripartite tricarboxylate transporter TctA family K07793 - - 2.11e-200 627.0
TLS2_k127_6347384_1 Cytidylate kinase-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006861 402.0
TLS2_k127_6348197_0 Periplasmic binding protein K01999 - - 2.147e-248 771.0
TLS2_k127_6348197_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 576.0
TLS2_k127_6348197_2 AMP-binding enzyme K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 565.0
TLS2_k127_6348197_3 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008353 475.0
TLS2_k127_6348197_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002164 250.0
TLS2_k127_6348197_5 - - - - 0.00000004669 65.0
TLS2_k127_6370872_0 Diguanylate cyclase - - - 3.833e-238 759.0
TLS2_k127_6370872_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 431.0
TLS2_k127_6370872_2 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000732 196.0
TLS2_k127_6376575_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 6.315e-217 682.0
TLS2_k127_6376575_1 Permease, YjgP YjgQ K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009965 393.0
TLS2_k127_6376575_2 DNA polymerase III, chi subunit K02339 - 2.7.7.7 0.0000000000000000000000000000000000000002153 158.0
TLS2_k127_6379478_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K12256 - 2.6.1.113 1.865e-240 746.0
TLS2_k127_6379478_1 Required for the activity of the bacterial periplasmic transport system of putrescine K11073 - - 1.657e-205 645.0
TLS2_k127_6379478_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11076 - - 2.089e-196 617.0
TLS2_k127_6379478_3 transport system permease K11075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 491.0
TLS2_k127_6379478_4 transport system permease K11074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005968 428.0
TLS2_k127_6385627_0 ATP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000882 261.0
TLS2_k127_6385627_1 ATP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000177 259.0
TLS2_k127_6385627_2 Acid phosphatase homologues - - - 0.00000000000000000000000000000000000000000000000000001427 196.0
TLS2_k127_6385627_3 PFAM phosphoesterase, PA-phosphatase related K19302 - 3.6.1.27 0.0000000000000000000000005356 118.0
TLS2_k127_6392899_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 607.0
TLS2_k127_6392899_1 ATPsynthase alpha/beta subunit N-term extension K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 530.0
TLS2_k127_6392899_2 - - - - 0.000000000000009225 78.0
TLS2_k127_639625_0 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 554.0
TLS2_k127_639625_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001641 271.0
TLS2_k127_6396632_0 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 471.0
TLS2_k127_6396632_1 Redoxin domain protein K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007788 306.0
TLS2_k127_6396632_2 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000119 267.0
TLS2_k127_6396632_3 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000000000000001219 162.0
TLS2_k127_6396632_4 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000001901 160.0
TLS2_k127_6396632_5 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000000003644 100.0
TLS2_k127_6404472_0 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 2.736e-224 707.0
TLS2_k127_6404472_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007405 589.0
TLS2_k127_6407755_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K19969 - 4.2.3.152,4.2.3.4 7.929e-221 693.0
TLS2_k127_6407755_1 Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005459 595.0
TLS2_k127_6407755_2 TatD related DNase K07051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 519.0
TLS2_k127_6407755_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 490.0
TLS2_k127_6407755_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 392.0
TLS2_k127_6407755_5 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006064 313.0
TLS2_k127_6416456_0 Belongs to the CarA family K01956 - 6.3.5.5 6.558e-203 637.0
TLS2_k127_6416456_1 Carbamoyl-phosphate synthetase ammonia chain K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 426.0
TLS2_k127_6416456_2 Inhibitor of apoptosis-promoting Bax1 K19416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 361.0
TLS2_k127_6416456_3 Haem-degrading K11477 - - 0.0000000000000000000000000000000000000000000000000000006721 209.0
TLS2_k127_6420663_0 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001452 278.0
TLS2_k127_6420663_1 regulatory protein, arsR K22298 - - 0.0000000000000000000000000000000000000000000000000004406 187.0
TLS2_k127_6420663_2 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000002128 183.0
TLS2_k127_6420663_3 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000000000000000000000000006375 127.0
TLS2_k127_6420663_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000003746 66.0
TLS2_k127_6420730_0 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.0 1216.0
TLS2_k127_6420730_1 Crp Fnr family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 361.0
TLS2_k127_6420730_2 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008857 327.0
TLS2_k127_6420730_3 Protein of unknown function (DUF3494) - - - 0.000000000000000000000000000000000000000000000000000000000000000001105 250.0
TLS2_k127_6420730_4 cyclic-guanylate-specific phosphodiesterase activity - - - 0.000000000000000000000000000000000000000000000007555 180.0
TLS2_k127_6420730_5 - - - - 0.00000000000000000000000000000000001782 141.0
TLS2_k127_6420730_6 Histidine kinase - - - 0.000000000000001428 84.0
TLS2_k127_6420730_7 ABC transporter K02065 - - 0.00000007658 55.0
TLS2_k127_642272_0 Oxidoreductase FAD-binding domain K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 569.0
TLS2_k127_642272_1 Belongs to the cysteine synthase cystathionine beta- synthase family K12339 GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 522.0
TLS2_k127_642272_2 epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 424.0
TLS2_k127_642272_3 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 406.0
TLS2_k127_642272_4 Eukaryotic integral membrane protein (DUF1751) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 300.0
TLS2_k127_642272_5 PFAM ABC transporter related K01995 - - 0.00000000000000000000000000000002681 125.0
TLS2_k127_642826_0 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 521.0
TLS2_k127_642826_1 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000964 342.0
TLS2_k127_642826_2 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000369 237.0
TLS2_k127_642826_3 Domain of unknown function (DUF4143) K07133 - - 0.000000000000000000000000000000304 139.0
TLS2_k127_642826_4 ribonuclease BN K07058 - - 0.000158 45.0
TLS2_k127_6437739_0 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 505.0
TLS2_k127_6437739_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 430.0
TLS2_k127_6440415_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 553.0
TLS2_k127_6440415_1 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 546.0
TLS2_k127_6440415_2 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004122 385.0
TLS2_k127_6440415_3 Acyl carrier protein - - - 0.00000000000001925 76.0
TLS2_k127_6440415_4 NmrA-like family - - - 0.0000000000006623 70.0
TLS2_k127_644637_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 0.0 1389.0
TLS2_k127_644637_1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 1.885e-219 687.0
TLS2_k127_644637_2 Phage-associated protein - - - 0.000000008711 59.0
TLS2_k127_6460665_0 Phospholipase D. Active site motifs. K00995,K06131 - 2.7.8.5 3.612e-212 669.0
TLS2_k127_6460665_1 iron ion homeostasis - - - 0.000000000000000000000000000000006268 132.0
TLS2_k127_6460665_2 - - - - 0.0000000000000000000000000005717 119.0
TLS2_k127_6460665_3 Protein of unknown function (DUF3309) - - - 0.000000000000000005186 88.0
TLS2_k127_6460665_4 - - - - 0.00000000000003419 74.0
TLS2_k127_6460665_5 - - - - 0.0004736 48.0
TLS2_k127_6460985_0 ATPase MipZ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 331.0
TLS2_k127_6460985_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 315.0
TLS2_k127_6460985_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000003493 211.0
TLS2_k127_6466933_0 ABC transporter, transmembrane region K06147 - - 1.186e-295 917.0
TLS2_k127_6466933_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006412 510.0
TLS2_k127_6466933_2 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 319.0
TLS2_k127_6466933_3 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000000000000000000001054 216.0
TLS2_k127_6481634_0 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 511.0
TLS2_k127_6481634_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 394.0
TLS2_k127_6481634_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 321.0
TLS2_k127_6481634_3 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009865 301.0
TLS2_k127_6481634_4 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000006049 259.0
TLS2_k127_6481634_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000004806 191.0
TLS2_k127_6481634_6 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000009111 71.0
TLS2_k127_6487865_0 Protein of unknown function (DUF1688) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 508.0
TLS2_k127_6487865_1 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 394.0
TLS2_k127_6487865_2 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000000000000000000000000001956 221.0
TLS2_k127_6487865_3 GTP cyclohydrolase N terminal - - - 0.000000000000000000000000000000000000001308 147.0
TLS2_k127_6493502_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 466.0
TLS2_k127_6493502_1 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000009116 206.0
TLS2_k127_6493502_2 nuclear chromosome segregation - - - 0.000000000000001469 88.0
TLS2_k127_6506089_0 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 308.0
TLS2_k127_6506089_1 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000000000000000000000000000001007 193.0
TLS2_k127_6506089_2 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000001067 107.0
TLS2_k127_6513463_0 Histidine kinase - - - 7.728e-245 769.0
TLS2_k127_6513463_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 383.0
TLS2_k127_6513463_2 Crp Fnr family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 332.0
TLS2_k127_6513463_3 cell septum assembly - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008538 285.0
TLS2_k127_6513463_4 - - - - 0.00000000008849 63.0
TLS2_k127_6515763_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00066 - 1.1.1.132 1.942e-223 700.0
TLS2_k127_6515763_1 Glycosyl transferases group 1 K00786 - - 4.61e-205 657.0
TLS2_k127_6515763_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 482.0
TLS2_k127_6515763_3 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 341.0
TLS2_k127_6515763_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 363.0
TLS2_k127_6515763_5 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008802 306.0
TLS2_k127_6519750_0 TAP-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 570.0
TLS2_k127_6519750_1 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 316.0
TLS2_k127_6519750_2 ATPases associated with a variety of cellular activities K09697 - 3.6.3.7 0.00000000000000000000000000000000000000000000009106 173.0
TLS2_k127_6519750_3 Glutaredoxin - - - 0.0000000000000000000000000000000000000000006263 173.0
TLS2_k127_6533513_0 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 359.0
TLS2_k127_6533513_1 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004943 304.0
TLS2_k127_6533513_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 289.0
TLS2_k127_6533513_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000001809 186.0
TLS2_k127_6533513_4 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000000000000264 194.0
TLS2_k127_6533513_5 - - - - 0.00000000000000000000000506 116.0
TLS2_k127_6537982_0 Isocitrate lyase K01637 - 4.1.3.1 2.021e-256 795.0
TLS2_k127_6537982_1 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007191 526.0
TLS2_k127_6537982_2 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 491.0
TLS2_k127_654883_0 Tyrosine recombinase XerD K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 453.0
TLS2_k127_654883_1 Ligated ion channel L-glutamate- and glycine-binding site K02030,K10036 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 428.0
TLS2_k127_654883_2 Binding-protein-dependent transport system inner membrane component K02029 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000541 418.0
TLS2_k127_654883_3 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000184 147.0
TLS2_k127_654883_4 Auxin Efflux Carrier K07088 - - 0.000000000000005082 76.0
TLS2_k127_6565308_0 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 421.0
TLS2_k127_6565308_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 325.0
TLS2_k127_656765_0 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 459.0
TLS2_k127_656765_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 366.0
TLS2_k127_656765_2 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006659 336.0
TLS2_k127_6572429_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K03601,K04564 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009457 380.0
TLS2_k127_6572429_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 298.0
TLS2_k127_6572429_2 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000000000000000000005975 213.0
TLS2_k127_6572429_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601,K04564 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 0.00000000000009416 76.0
TLS2_k127_6597952_0 Bacterial protein of unknown function (DUF853) K06915 - - 3.186e-232 725.0
TLS2_k127_6597952_1 transcriptional regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 401.0
TLS2_k127_6600016_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 5.532e-238 742.0
TLS2_k127_6600016_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006343 575.0
TLS2_k127_6600016_2 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 418.0
TLS2_k127_6600016_3 ATPases associated with a variety of cellular activities K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 376.0
TLS2_k127_6600016_4 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000066 291.0
TLS2_k127_6600016_5 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000004137 215.0
TLS2_k127_6600016_6 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000001376 209.0
TLS2_k127_6600016_7 CYTH - - - 0.0000000000000000000000000000000000000000000000000001899 195.0
TLS2_k127_6600016_8 DSBA oxidoreductase - - - 0.0000000000000000000000000000000001035 135.0
TLS2_k127_6600016_9 H-NS histone family K03746 - - 0.00000000000000000000000000215 115.0
TLS2_k127_6609697_0 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 1.779e-206 653.0
TLS2_k127_6609697_1 Beta-ketoacyl synthase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 406.0
TLS2_k127_6609697_2 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009538 259.0
TLS2_k127_6609697_3 dehydratase - - - 0.0000000000000000000000000000000000000000000000000003416 196.0
TLS2_k127_6609697_4 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000005824 83.0
TLS2_k127_6623395_0 4Fe-4S dicluster domain - - - 0.0 1053.0
TLS2_k127_6623395_1 Protein of unknown function (DUF3306) - - - 0.000000000000000000000000000000905 128.0
TLS2_k127_6623395_2 Nitrate reductase delta subunit - - - 0.000000000000000000509 88.0
TLS2_k127_6633465_0 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 497.0
TLS2_k127_6633465_1 LysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008678 422.0
TLS2_k127_6633465_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 381.0
TLS2_k127_6633465_3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 328.0
TLS2_k127_6633465_4 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.0000000005986 61.0
TLS2_k127_6642129_0 oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 460.0
TLS2_k127_6642129_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007768 346.0
TLS2_k127_6647287_0 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003719 255.0
TLS2_k127_6647287_1 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000002859 226.0
TLS2_k127_6647287_2 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000004406 187.0
TLS2_k127_6647287_3 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000000000000000000000000000000000002063 146.0
TLS2_k127_6647287_4 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000005986 61.0
TLS2_k127_6653007_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 6.228e-252 797.0
TLS2_k127_6653007_1 two-component sensor kinase K07649 - 2.7.13.3 2.895e-200 635.0
TLS2_k127_6653007_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 5.283e-200 630.0
TLS2_k127_6653007_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 2.127e-198 624.0
TLS2_k127_6653007_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 572.0
TLS2_k127_6653007_5 PFAM response regulator receiver K02483,K07666,K07774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 412.0
TLS2_k127_6653007_6 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 386.0
TLS2_k127_6653007_7 Rod shape-determining protein mreD K03571 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001239 270.0
TLS2_k127_6653007_8 Modulates RecA activity K03565 - - 0.00000000000000000000000000000000000000000000000000000000007433 207.0
TLS2_k127_6673743_0 AcrB/AcrD/AcrF family K18138,K18146,K18902 - - 0.0 1563.0
TLS2_k127_6673743_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009097 466.0
TLS2_k127_6673743_2 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000212 252.0
TLS2_k127_6697975_0 molybdopterin cofactor binding K08352 - 1.8.5.5 6.047e-298 930.0
TLS2_k127_6710321_0 Serine threonine protein kinase - - - 8.814e-201 631.0
TLS2_k127_6710321_1 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 408.0
TLS2_k127_6719229_0 Neisseria PilC beta-propeller domain K02674 - - 3.514e-258 838.0
TLS2_k127_6719229_1 Type IV Pilus-assembly protein W K02672 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001812 261.0
TLS2_k127_6719229_2 Type IV minor pilin ComP, DNA uptake sequence receptor K02655 - - 0.0000000000000000000000000000000000000000003131 166.0
TLS2_k127_6719229_3 Type II transport protein GspH K08084 - - 0.00000000000000000000000000000000000000002874 166.0
TLS2_k127_6719229_4 Pilus assembly protein PilX - - - 0.000000000000000000000000000000008123 143.0
TLS2_k127_6719229_5 type IV pilus modification protein PilV K02671 - - 0.0000000000000000000000191 105.0
TLS2_k127_6720921_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 1.591e-313 980.0
TLS2_k127_6720921_1 Transposase DDE domain - - - 1.018e-216 679.0
TLS2_k127_6720921_2 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 4.927e-216 677.0
TLS2_k127_6720921_3 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008177 495.0
TLS2_k127_6720921_4 Tripartite ATP-independent periplasmic transporter DctQ component - - - 0.000000000000000000000000000000000000000000000000000000005748 220.0
TLS2_k127_6720921_5 Salmonella virulence plasmid 65kDa B protein - - - 0.00000000000000000000000000000000000000000000006171 181.0
TLS2_k127_6728407_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1439.0
TLS2_k127_6728407_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 6.625e-238 742.0
TLS2_k127_6728407_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 1.86e-199 625.0
TLS2_k127_675687_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.263e-311 958.0
TLS2_k127_675687_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 8.007e-258 815.0
TLS2_k127_675687_2 transposase IS204 IS1001 IS1096 IS1165 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 287.0
TLS2_k127_675687_3 Domain of unknown function (DUF4124) - - - 0.000000000000000000000000000000000000000008661 160.0
TLS2_k127_675687_4 Belongs to the UPF0125 (RnfH) family K09801 - - 0.00000000000000000000000008732 110.0
TLS2_k127_675687_6 - - - - 0.0001414 46.0
TLS2_k127_6757216_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity K03583 - 3.1.11.5 2.316e-226 718.0
TLS2_k127_6757216_1 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582,K16898 - 3.1.11.5,3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 578.0
TLS2_k127_6759193_0 Aminotransferase class-III K01845 - 5.4.3.8 1.535e-245 764.0
TLS2_k127_6759193_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000948 470.0
TLS2_k127_6759193_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 290.0
TLS2_k127_6759193_3 PFAM CHAD domain containing protein - - - 0.00000000000000000000000000000003096 132.0
TLS2_k127_676032_0 PFAM Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 471.0
TLS2_k127_676032_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 344.0
TLS2_k127_676032_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000393 235.0
TLS2_k127_676032_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000003867 192.0
TLS2_k127_6773562_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000663 562.0
TLS2_k127_6773562_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 332.0
TLS2_k127_6773562_2 - - - - 0.00000000000000009846 94.0
TLS2_k127_6776986_0 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009615 529.0
TLS2_k127_6776986_1 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005397 261.0
TLS2_k127_6790485_0 Fatty acid hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 471.0
TLS2_k127_6790485_1 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 364.0
TLS2_k127_6790485_2 Etoposide-induced protein 2.4 (EI24) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009023 336.0
TLS2_k127_6790485_3 Probable molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 304.0
TLS2_k127_6790485_4 40-residue YVTN family beta-propeller repeat protein - - - 0.0000000000009377 68.0
TLS2_k127_6793554_0 Chemotaxis sensory transducer K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 372.0
TLS2_k127_6793554_1 Protein of unknown function (DUF1178) - - - 0.000000000000000000000000000000000000000297 152.0
TLS2_k127_6793554_3 glycolate oxidase subunit GlcD - - - 0.000000000003735 66.0
TLS2_k127_6793846_0 FAD linked oxidases, C-terminal domain K00102,K03777 - 1.1.2.4,1.1.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 555.0
TLS2_k127_6793846_1 Cobalamin adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 309.0
TLS2_k127_6793846_2 - - - - 0.00009202 45.0
TLS2_k127_6794043_0 DNA topoisomerase III K03169 - 5.99.1.2 4.799e-218 682.0
TLS2_k127_6794043_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 1.704e-207 654.0
TLS2_k127_6794043_2 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 346.0
TLS2_k127_6794043_3 Belongs to the UPF0235 family K09131 - - 0.000000000000000000000000000115 118.0
TLS2_k127_67969_0 COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 550.0
TLS2_k127_67969_1 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 505.0
TLS2_k127_67969_2 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 482.0
TLS2_k127_67969_3 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007939 441.0
TLS2_k127_67969_4 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.000000303 57.0
TLS2_k127_6826486_0 Peptidase C39 family K13409 - - 1.231e-305 954.0
TLS2_k127_6826486_1 HlyD family secretion protein K13408 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 379.0
TLS2_k127_6826486_2 Ca2 -binding protein (EF-Hand superfamily - - - 0.0000068 53.0
TLS2_k127_6830363_0 Helix-turn-helix domain, rpiR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 336.0
TLS2_k127_6830363_1 Oxidoreductase family, NAD-binding Rossmann fold K00010 - 1.1.1.18,1.1.1.369 0.000000000000000000000000000000000000000000000000000000007312 201.0
TLS2_k127_6830363_2 Periplasmic binding proteins and sugar binding domain of LacI family K02058 - - 0.000000000000000001529 89.0
TLS2_k127_6851024_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 1.24e-322 1012.0
TLS2_k127_6851024_1 Tryptophan halogenase K14266 - 1.14.19.9 9.899e-216 698.0
TLS2_k127_6851024_2 Glycosyl hydrolase family 30 beta sandwich domain K01201 - 3.2.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 602.0
TLS2_k127_6851024_3 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 433.0
TLS2_k127_6851024_4 formate dehydrogenase, alpha subunit K00123,K22015 - 1.17.1.9,1.17.99.7 0.000000000000000000000000000000000000000000000000000000000000000000000000003292 254.0
TLS2_k127_6851024_5 Phosphoribosyl transferase domain K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000001503 230.0
TLS2_k127_688506_0 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 376.0
TLS2_k127_688506_1 Outer membrane efflux protein - - - 0.000000000000000000000000000000000003279 143.0
TLS2_k127_688506_2 - - - - 0.0000000000000002848 85.0
TLS2_k127_6888541_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 9.026e-276 852.0
TLS2_k127_6888541_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 614.0
TLS2_k127_6888541_2 Integral membrane protein (DUF2244) - - - 0.000000000000000000000000000002217 128.0
TLS2_k127_6888541_3 Methyltransferase domain K02169 - 2.1.1.197 0.00000000003298 64.0
TLS2_k127_6891431_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1373.0
TLS2_k127_6891431_1 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 433.0
TLS2_k127_6891431_2 Predicted integral membrane protein (DUF2189) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 377.0
TLS2_k127_6891431_3 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000000000000000000000000000001243 233.0
TLS2_k127_6891431_4 Peptidase M15 - - - 0.00000000000000000000000000000000000000000000000000000000000000001543 229.0
TLS2_k127_6904752_0 Cytochrome C and Quinol oxidase polypeptide I K04561 - 1.7.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 516.0
TLS2_k127_6904752_1 PFAM ATPase associated with various cellular activities K04748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009947 434.0
TLS2_k127_6904752_2 PFAM von Willebrand factor type A K02448 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 391.0
TLS2_k127_6916509_0 diguanylate cyclase K21019 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009702 381.0
TLS2_k127_6916509_1 EamA-like transporter family K15268 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 364.0
TLS2_k127_6916509_2 peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 357.0
TLS2_k127_6916509_3 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008039 259.0
TLS2_k127_6916509_4 ApaG domain K06195 - - 0.00000000000000000000000000000000000000000000000000000000009767 205.0
TLS2_k127_6928097_0 Type II secretion system (T2SS), protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006802 252.0
TLS2_k127_6928097_1 Type II secretion system (T2SS), protein G - - - 0.000000000000000000000000000000000000000000000000007435 186.0
TLS2_k127_6928097_2 Prokaryotic N-terminal methylation motif K02458 - - 0.0000000000001566 77.0
TLS2_k127_6928097_3 Prokaryotic N-terminal methylation motif K02456 - - 0.0002601 52.0
TLS2_k127_6941964_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K21307 - 1.8.5.6 0.0 1593.0
TLS2_k127_6941964_1 PFAM 4Fe-4S K00184,K21308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 378.0
TLS2_k127_6944986_0 NADH flavin oxidoreductase NADH oxidase K10680 GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 599.0
TLS2_k127_6944986_1 AMP-binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 485.0
TLS2_k127_6944986_2 Thermostable hemolysin - - - 0.000000000000000000000000000000000000000000000000000000000003338 218.0
TLS2_k127_6944986_3 Protein of unknown function (DUF454) K09790 - - 0.000000000000000000000000000000000001834 149.0
TLS2_k127_6944986_4 Invasion gene expression up-regulator, SirB - - - 0.00000000000000000000000000000000007994 141.0
TLS2_k127_6944986_5 SpoVT / AbrB like domain - - - 0.00000000001151 68.0
TLS2_k127_6953421_0 MMPL family - - - 0.0 1611.0
TLS2_k127_6953421_1 Receptor family ligand binding region K01999 - - 3.849e-224 699.0
TLS2_k127_6953421_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007363 495.0
TLS2_k127_6953421_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 495.0
TLS2_k127_6953421_4 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 462.0
TLS2_k127_6953421_5 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 463.0
TLS2_k127_6953421_6 PFAM ABC transporter related K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 410.0
TLS2_k127_6953421_7 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 400.0
TLS2_k127_6953421_8 3'(2'),5'-bisphosphate nucleotidase K01082 - 3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 309.0
TLS2_k127_6953421_9 Polyhydroxyalkanoate synthesis repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004085 255.0
TLS2_k127_6963306_0 TIGRFAM type IV-A pilus assembly ATPase PilB K02454,K02504,K02652 - - 1.736e-318 981.0
TLS2_k127_6963306_1 Type II secretion system K02653 - - 6.11e-220 687.0
TLS2_k127_6963306_2 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 470.0
TLS2_k127_6963306_3 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 415.0
TLS2_k127_6963306_4 regulator K18831 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 375.0
TLS2_k127_6963306_5 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000002896 220.0
TLS2_k127_6963306_7 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000000001951 87.0
TLS2_k127_6963306_8 protein conserved in bacteria K19166 - - 0.0000001975 59.0
TLS2_k127_6963306_9 Plasmid replication region DNA-binding N-term - - - 0.0001525 47.0
TLS2_k127_6984136_0 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 490.0
TLS2_k127_6984136_1 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 364.0
TLS2_k127_6984136_2 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.00000000000000000000009211 111.0
TLS2_k127_6991409_0 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.0 1214.0
TLS2_k127_6991409_1 type II and III secretion system protein K02666 - - 0.0 1028.0
TLS2_k127_6991409_10 Belongs to the frataxin family K06202 - - 0.0000000000000000000000000000000000000000000000007736 177.0
TLS2_k127_6991409_11 Large extracellular alpha-helical protein - - - 0.0000000000000000006021 98.0
TLS2_k127_6991409_2 pilus assembly protein PilM K02662 - - 5.379e-210 655.0
TLS2_k127_6991409_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 2.022e-198 628.0
TLS2_k127_6991409_4 Gram-negative porin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 444.0
TLS2_k127_6991409_5 Pilus assembly protein, PilO K02664 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 307.0
TLS2_k127_6991409_6 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 300.0
TLS2_k127_6991409_7 Fimbrial assembly K02663 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004273 270.0
TLS2_k127_6991409_8 pilus assembly protein PilP K02665 - - 0.000000000000000000000000000000000000000000000000000000000000000000002024 247.0
TLS2_k127_6991409_9 OsmC-like protein K07397 - - 0.000000000000000000000000000000000000000000000000001534 183.0
TLS2_k127_7010745_0 Tripartite tricarboxylate transporter family receptor K07795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 478.0
TLS2_k127_7010745_1 Histidine kinase K07649 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 426.0
TLS2_k127_7023978_0 Tetratricopeptide repeat - - - 6.682e-199 637.0
TLS2_k127_7023978_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001359 273.0
TLS2_k127_7023978_2 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.0000000000000000000000000000000000000000000000000009869 190.0
TLS2_k127_7023978_3 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000009743 164.0
TLS2_k127_7037987_0 Phosphonate ABC transporter K02042 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 424.0
TLS2_k127_7037987_1 binding-protein-dependent transport systems inner membrane component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 407.0
TLS2_k127_7037987_2 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000000000000000000000000000000000004423 174.0
TLS2_k127_7037987_3 - - - - 0.0000000000000000000000000000000938 128.0
TLS2_k127_7037987_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000001078 111.0
TLS2_k127_7044081_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 362.0
TLS2_k127_7044081_1 type IV pilus modification protein PilV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001265 266.0
TLS2_k127_7044081_2 Pilus assembly protein PilX - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000029 268.0
TLS2_k127_7044081_3 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000005614 154.0
TLS2_k127_7044081_4 General secretion pathway protein K02672 - - 0.0000000000000000000000000000000000005025 150.0
TLS2_k127_7044081_5 Type II transport protein GspH K08084 - - 0.0000000000000000000000000000000005617 138.0
TLS2_k127_7044081_6 Type IV minor pilin ComP, DNA uptake sequence receptor K02655 - - 0.0000000000000000000000007971 111.0
TLS2_k127_7044081_7 type 4 fimbrial pilin related transmembrane protein K08084 - - 0.00009404 53.0
TLS2_k127_7054265_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 375.0
TLS2_k127_7054265_1 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003654 267.0
TLS2_k127_7104963_0 Transketolase, C-terminal domain K00167 - 1.2.4.4 5.177e-197 619.0
TLS2_k127_7104963_1 e3 binding domain K09699 - 2.3.1.168 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006489 520.0
TLS2_k127_7104963_2 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001962 276.0
TLS2_k127_7104963_3 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 GO:0001522,GO:0003674,GO:0003824,GO:0004730,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016043,GO:0016070,GO:0016787,GO:0016798,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0030145,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0090304,GO:1901360 4.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002153 279.0
TLS2_k127_7104963_4 PFAM Dehydrogenase, E1 component K00166 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000009139 203.0
TLS2_k127_7116995_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 2.911e-214 673.0
TLS2_k127_7116995_1 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000000000000002128 151.0
TLS2_k127_7121937_0 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 542.0
TLS2_k127_7121937_1 ABC transporter substrate-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000002589 227.0
TLS2_k127_7124427_0 Cys/Met metabolism PLP-dependent enzyme K01760 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 561.0
TLS2_k127_7124427_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 399.0
TLS2_k127_7124427_2 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001436 261.0
TLS2_k127_7124427_3 cyclase dehydrase - - - 0.0000000000000000000000000000000000000000000000000000000006127 206.0
TLS2_k127_712582_0 CPA1 family monovalent cation H antiporter K03316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007657 425.0
TLS2_k127_712582_1 Amidase K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 308.0
TLS2_k127_712582_2 Universal stress protein family - - - 0.0000000000000000000000000000000000000000001072 172.0
TLS2_k127_7145254_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1019.0
TLS2_k127_7145254_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 6.081e-284 886.0
TLS2_k127_7145254_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 2.698e-236 734.0
TLS2_k127_7145254_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.681e-202 635.0
TLS2_k127_7145254_4 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000009559 241.0
TLS2_k127_7145254_5 - - - - 0.0000000000000000000000000000000000000000000000000000274 201.0
TLS2_k127_7145254_6 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000002809 145.0
TLS2_k127_7145254_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000007655 110.0
TLS2_k127_7145254_8 Thioesterase superfamily protein K01073 - 3.1.2.20 0.0000000000000000001361 102.0
TLS2_k127_7157476_0 phosphoesterase, PHP K07053 GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 467.0
TLS2_k127_7157476_1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000003844 84.0
TLS2_k127_7157476_2 Belongs to the DEAD box helicase family - GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - 0.000000000001279 74.0
TLS2_k127_7157738_0 DNA photolyase K01669 - 4.1.99.3 4.555e-244 763.0
TLS2_k127_7157738_1 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 593.0
TLS2_k127_7157738_2 Amidohydrolase family K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 392.0
TLS2_k127_7157738_3 Belongs to the UPF0301 (AlgH) family K07735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 326.0
TLS2_k127_7157738_4 uracil phosphoribosyltransferase K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000002162 253.0
TLS2_k127_7157738_5 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000003029 211.0
TLS2_k127_7157738_6 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000000000000000000000000002338 201.0
TLS2_k127_7179033_0 PFAM Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007989 347.0
TLS2_k127_7179033_1 4Fe-4S binding domain K08358 - - 0.000000000000000000000000000000000000000000000000000000000000000000004004 258.0
TLS2_k127_7179033_2 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000003464 217.0
TLS2_k127_7179033_3 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.0000000000000000000000001391 120.0
TLS2_k127_7179033_4 - - - - 0.0000000000000000000003934 99.0
TLS2_k127_7179033_5 COG2863 Cytochrome c553 - - - 0.00000000000000000000072 109.0
TLS2_k127_7180384_0 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 466.0
TLS2_k127_7180384_1 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000533 98.0
TLS2_k127_7180384_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.0000000214 60.0
TLS2_k127_7180384_3 NYN domain - - - 0.000000101 54.0
TLS2_k127_7190391_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 9.302e-311 964.0
TLS2_k127_7190391_1 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.00000000000000000000000001599 110.0
TLS2_k127_7214782_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 2.191e-236 735.0
TLS2_k127_7214782_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005362 325.0
TLS2_k127_7214782_2 reductase K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004359 311.0
TLS2_k127_7214782_3 PFAM Anti sigma-E protein RseA K03597 - - 0.0000000000000000000000000000000000000000000005847 173.0
TLS2_k127_7214782_4 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000000000005646 146.0
TLS2_k127_724029_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 4.119e-287 893.0
TLS2_k127_724029_1 Ferredoxin, 2Fe-2S type, ISC system K04755 - - 0.0000000000000000000000000000000000000000000000000000000000000000001475 229.0
TLS2_k127_724029_2 Phosphoglycerate mutase family - - - 0.00000000000002292 72.0
TLS2_k127_7257669_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004059 533.0
TLS2_k127_7257669_1 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005341 409.0
TLS2_k127_7257669_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 347.0
TLS2_k127_7257669_3 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 295.0
TLS2_k127_7257669_4 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004372 224.0
TLS2_k127_7257962_0 SMART AAA ATPase K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005987 454.0
TLS2_k127_7257962_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009386 445.0
TLS2_k127_7257962_2 Bacterial protein of unknown function (DUF839) K07093 - - 0.0000000000000000000000000000000000003485 144.0
TLS2_k127_7267404_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261 - 1.4.1.2,1.4.1.3 1.002e-243 760.0
TLS2_k127_7273086_0 histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 516.0
TLS2_k127_7273086_1 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 520.0
TLS2_k127_7273086_2 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 302.0
TLS2_k127_7285269_0 Nucleoside recognition - - - 1.114e-203 644.0
TLS2_k127_7285269_1 Peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004226 413.0
TLS2_k127_7285269_2 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.000000000000000000000000000000000000000000000000000000000000002218 226.0
TLS2_k127_7291742_0 Domain of unknown function (DUF3390) K18929 - - 1.483e-203 648.0
TLS2_k127_7291742_1 Belongs to the binding-protein-dependent transport system permease family K05832 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 400.0
TLS2_k127_7291742_2 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003688 394.0
TLS2_k127_7291742_3 transport system ATPase component K05833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 389.0
TLS2_k127_7291742_4 (Fe-S) oxidoreductase K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 355.0
TLS2_k127_7291742_5 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004906 256.0
TLS2_k127_7291742_6 LUD domain K00782 - - 0.00000000000000000000000000000000000000001433 168.0
TLS2_k127_7292879_0 Guanine deaminase K01487 - 3.5.4.3 2.612e-212 670.0
TLS2_k127_7292879_1 Leucine-rich repeat (LRR) protein - - - 5.494e-195 659.0
TLS2_k127_7292879_2 CO dehydrogenase flavoprotein domain protein K13481 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009704 281.0
TLS2_k127_7293394_0 Polysaccharide biosynthesis/export protein - - - 5.637e-234 739.0
TLS2_k127_7293394_1 COG3524 Capsule polysaccharide export protein K10107 - - 0.000000000000000000000000000001471 122.0
TLS2_k127_7300842_0 TonB C terminal K03832 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 405.0
TLS2_k127_7300842_1 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008947 316.0
TLS2_k127_7300842_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000212 241.0
TLS2_k127_7321506_0 PFAM AMP-dependent synthetase and ligase K20034 - 6.2.1.44 3.797e-283 877.0
TLS2_k127_7321506_1 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 1.077e-259 827.0
TLS2_k127_7321506_2 PFAM Cytochrome c, class I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 431.0
TLS2_k127_7325163_0 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 1.486e-298 917.0
TLS2_k127_7325163_1 LysR substrate binding domain K21703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 509.0
TLS2_k127_7325163_2 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K01086,K03841 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006848 383.0
TLS2_k127_7325163_3 Putative aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004089 340.0
TLS2_k127_7325163_4 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.000000000000000000000000000000000000003913 158.0
TLS2_k127_734677_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) K11711 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006864 442.0
TLS2_k127_734677_1 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004259 410.0
TLS2_k127_734677_2 response regulator, receiver K11712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006438 351.0
TLS2_k127_734677_3 Protein of unknown function (DUF1653) - - - 0.0000000000000000000000004407 113.0
TLS2_k127_734677_4 Oxidoreductase-like protein, N-terminal - - - 0.00000000000000006725 89.0
TLS2_k127_7357973_0 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003617 414.0
TLS2_k127_7357973_1 COG3170 Tfp pilus assembly protein FimV K08086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001999 263.0
TLS2_k127_7357973_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000006259 248.0
TLS2_k127_7360649_0 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 479.0
TLS2_k127_7360649_1 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008007 280.0
TLS2_k127_7360649_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000002464 211.0
TLS2_k127_7363672_0 carboxylase K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009327 563.0
TLS2_k127_7363672_1 HMGL-like K01640 GO:0000287,GO:0003674,GO:0003824,GO:0004419,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006552,GO:0006605,GO:0006625,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0019752,GO:0022607,GO:0030145,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0046950,GO:0046951,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564,GO:1901565,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 499.0
TLS2_k127_7363672_2 2-hydroxychromene-2-carboxylate isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000103 264.0
TLS2_k127_7363672_3 YbaK prolyl-tRNA synthetase associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000382 241.0
TLS2_k127_7363672_4 Protein of unknown function (DUF1289) K06938 - - 0.000000000000003105 81.0
TLS2_k127_7369259_0 Fe-S oxidoreductase K21834 - - 9.607e-286 884.0
TLS2_k127_7369259_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 2.811e-243 756.0
TLS2_k127_7369259_2 Nitrate reductase gamma subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 388.0
TLS2_k127_7369259_3 NADPH-dependent glutamate synthase beta - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006196 346.0
TLS2_k127_7369259_4 DsrC like protein K11179 - - 0.000000000000000000000000000000000000000000000000000000000000002807 220.0
TLS2_k127_7369259_5 DsrH like protein K07237 - - 0.000000000146 62.0
TLS2_k127_7373251_0 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 552.0
TLS2_k127_7373251_1 PFAM ABC transporter K09972,K10004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 443.0
TLS2_k127_7373251_2 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029,K10003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 425.0
TLS2_k127_7373251_3 polar amino acid ABC transporter, inner membrane subunit K10002 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 314.0
TLS2_k127_7373251_4 NYN domain - - - 0.0000000000000000000000000000000000000000000000000000000000001428 222.0
TLS2_k127_7383414_0 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007352 563.0
TLS2_k127_7383414_1 VanZ like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003334 278.0
TLS2_k127_7383414_2 Uncharacterised protein family (UPF0093) K08973 - - 0.000000000000000000000000000000000000000000000000000000000000002437 220.0
TLS2_k127_7384682_0 Putative diguanylate phosphodiesterase - - - 0.0 1090.0
TLS2_k127_7384682_1 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 437.0
TLS2_k127_7384682_2 Histidine Phosphotransfer domain - - - 0.00000000000000001702 89.0
TLS2_k127_7384682_3 response regulator K22010 - - 0.0000000000000002992 79.0
TLS2_k127_7386291_0 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 3.295e-243 754.0
TLS2_k127_7386291_1 Belongs to the TPP enzyme family K01577 - 4.1.1.8 3.831e-201 629.0
TLS2_k127_7395791_0 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 407.0
TLS2_k127_7395791_1 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008619 330.0
TLS2_k127_7395791_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000005084 226.0
TLS2_k127_7395791_3 Lytic transglycosylase catalytic K08309 - - 0.00000000000000000000000000000007038 126.0
TLS2_k127_7397539_0 Male sterility protein - - - 5.634e-240 747.0
TLS2_k127_7397539_1 Poly(hydroxyalcanoate) granule associated protein (phasin) - - - 0.000000000000000000000000000000000000000000000000002316 189.0
TLS2_k127_7411624_0 PFAM Phosphoglycerate mutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002215 260.0
TLS2_k127_7411624_1 Domain of unknown function (DUF4178) - - - 0.00000000000000000000000000000000000002546 149.0
TLS2_k127_7411624_2 Domain of Unknown Function (DUF350) - - - 0.00000000000000000000000000006112 120.0
TLS2_k127_7423128_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1219.0
TLS2_k127_7423128_1 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 2.282e-230 720.0
TLS2_k127_7423128_2 PIN domain K07064 GO:0005575,GO:0005576 - 0.0000000000000000000000000000001404 128.0
TLS2_k127_7423128_3 - - - - 0.00000000000000006673 83.0
TLS2_k127_7433246_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K00249,K00294,K13821 - 1.2.1.88,1.3.8.7,1.5.5.2 0.0 1434.0
TLS2_k127_7433246_1 Thioredoxin K05838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005774 351.0
TLS2_k127_7439968_0 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 604.0
TLS2_k127_7439968_1 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 457.0
TLS2_k127_7439968_2 Binding-protein-dependent transport system inner membrane component K02026,K05815,K17246 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 442.0
TLS2_k127_7439968_3 Glycosyl hydrolase family 1 K01223,K05350 - 3.2.1.21,3.2.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 377.0
TLS2_k127_7439968_4 Cellulase (glycosyl hydrolase family 5) K01179 - 3.2.1.4 0.000000000000000000000000000000000000000000000000001074 187.0
TLS2_k127_7448193_0 Glycosyl transferase family 2 K01002 - 2.7.8.20 1.332e-263 833.0
TLS2_k127_7448193_1 peptidase - - - 0.00000000003984 75.0
TLS2_k127_7454453_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1425.0
TLS2_k127_7454453_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007268 424.0
TLS2_k127_7461130_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 325.0
TLS2_k127_7461130_1 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000009327 205.0
TLS2_k127_7461130_2 Cyclic nucleotide-binding domain - - - 0.00003355 52.0
TLS2_k127_765586_0 Transport of potassium into the cell K03549 - - 2.03e-322 997.0
TLS2_k127_765586_1 homocysteine S-methyltransferase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 593.0
TLS2_k127_765586_2 Glutamate-cysteine ligase K01919 - 6.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 533.0
TLS2_k127_765586_3 Putative diguanylate phosphodiesterase K21023 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 432.0
TLS2_k127_765586_4 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000004232 159.0
TLS2_k127_780759_0 PFAM D-galactarate dehydratase Altronate hydrolase domain protein K16846 - 4.4.1.24 1.054e-230 718.0
TLS2_k127_780759_1 Tripartite tricarboxylate transporter TctA family K07793 - - 2.763e-205 649.0
TLS2_k127_780759_2 Belongs to the LDH2 MDH2 oxidoreductase family K13609,K16844 - 1.1.1.338,1.5.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 480.0
TLS2_k127_780759_3 D-isomer specific 2-hydroxyacid dehydrogenase K00058,K16843 - 1.1.1.310,1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 417.0
TLS2_k127_780759_4 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 415.0
TLS2_k127_780759_5 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 377.0
TLS2_k127_780759_6 UTRA domain K03710 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 313.0
TLS2_k127_780759_7 SAF K16845 - 4.4.1.24 0.0000000000000000000000000000000000000000000002126 169.0
TLS2_k127_780759_8 Tripartite tricarboxylate transporter TctB family - - - 0.00000000003428 74.0
TLS2_k127_81007_0 Guanine deaminase K01487 - 3.5.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 486.0
TLS2_k127_81007_1 Basic membrane lipoprotein K02058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 421.0
TLS2_k127_83739_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 382.0
TLS2_k127_83739_1 lipase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 301.0
TLS2_k127_83739_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000446 144.0
TLS2_k127_83739_3 PQ loop repeat K15383 - - 0.00000000000000000000000000009591 118.0
TLS2_k127_83739_4 Peptidase M22, glycoprotease K14742 - - 0.00000000001412 66.0
TLS2_k127_837905_0 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 525.0
TLS2_k127_837905_1 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 485.0
TLS2_k127_837905_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007353 484.0
TLS2_k127_837905_3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281 - 3.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000124 246.0
TLS2_k127_837905_4 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000000000000000004019 117.0
TLS2_k127_845937_0 leucine binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 333.0
TLS2_k127_845937_1 SCO1/SenC - - - 0.000000000000000000000000000000000000000000000002074 178.0
TLS2_k127_853163_0 DEAD-like helicases superfamily - - - 7.632e-234 729.0
TLS2_k127_853163_1 transcriptional regulator, ModE family K02019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003715 254.0
TLS2_k127_853163_2 COG0725 ABC-type molybdate transport system, periplasmic component K02020 - - 0.000000000000000000000000001151 115.0
TLS2_k127_876430_0 Fructose-bisphosphate aldolase, class II, Calvin cycle subtype K01624 - 4.1.2.13 8.105e-198 620.0
TLS2_k127_876430_1 STAS-like domain of unknown function (DUF4325) - - - 0.00000000000000000000000000000000000000000448 164.0
TLS2_k127_876430_2 PFAM PfkB domain protein K00852,K00856 - 2.7.1.15,2.7.1.20 0.000000000000000000001225 94.0
TLS2_k127_890284_0 AMP-binding enzyme K01897 - 6.2.1.3 1.299e-302 934.0
TLS2_k127_890284_1 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 593.0
TLS2_k127_890284_2 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 385.0
TLS2_k127_890284_3 Protein of unknown function (DUF4243) - - - 0.0000000000000000000000000000000000000000000000001997 189.0
TLS2_k127_890284_4 Chalcone isomerase-like - - - 0.000000000000000000000000000000000000000000000001056 181.0
TLS2_k127_890284_5 CoA-transferase family III K01796 - 5.1.99.4 0.00000000001268 65.0
TLS2_k127_890284_7 PFAM AMP-dependent synthetase and ligase K00666 - - 0.0001754 45.0
TLS2_k127_890284_8 redox-sensitive transcriptional activator SoxR K13639 - - 0.0006895 47.0
TLS2_k127_937764_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 9.045e-220 696.0
TLS2_k127_937764_1 endonuclease III K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005996 321.0
TLS2_k127_937764_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000004703 261.0
TLS2_k127_937764_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000001177 266.0
TLS2_k127_937764_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000004286 155.0
TLS2_k127_937764_5 Transcriptional regulator, LysR family K13634 - - 0.000000000000000000000000001267 113.0
TLS2_k127_95181_0 glutamine synthetase K01915 - 6.3.1.2 2.411e-276 853.0
TLS2_k127_95181_1 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 396.0
TLS2_k127_95181_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K12256 - 2.6.1.113 0.000000000000000000000000000000000000002394 148.0
TLS2_k127_95181_3 FAD dependent oxidoreductase K09471 - - 0.00000000000000000000000000000000008081 134.0
TLS2_k127_958218_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 9.622e-267 849.0
TLS2_k127_958218_1 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 377.0
TLS2_k127_974438_0 GGDEF domain - - - 3.586e-214 699.0
TLS2_k127_982539_0 Rieske 2Fe-2S K00499 - 1.14.15.7 6.433e-196 617.0
TLS2_k127_982539_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000007637 183.0
TLS2_k127_998380_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 4.228e-274 857.0